item: #1 of 427 id: cord-000285-7p3b6tyf author: HARTERT, Tina V. title: The Tennessee Children's Respiratory Initiative: Objectives, design and recruitment results of a prospective cohort study investigating infant viral respiratory illness and the development of asthma and allergic diseases date: 2010-04-08 words: 3853 flesch: 29 summary: The TCRI is a prospective cohort of mother-infant dyads enrolled in a longitudinal investigation of the relationship of infant viral respiratory infection severity and aetiology and the interaction of other risk factors on the development of childhood asthma and allergic diseases. The primary goals of the study are: (i) to investigate both the acute and the long-term health consequences of varying severity and aetiology of clinically significant viral respiratory tract infections on the outcomes of allergic rhinitis (AR) and early childhood asthma; and (ii) to identify the potentially modifiable factors that define children who are at greatest risk of developing asthma following infant respiratory viral infection. keywords: asthma; atopic; childhood; children; cohort; development; infant; infection; severity; study cache: cord-000285-7p3b6tyf.txt plain text: cord-000285-7p3b6tyf.txt item: #2 of 427 id: cord-000602-z5p3a64x author: Bhat, Niranjan title: Use and Evaluation of Molecular Diagnostics for Pneumonia Etiology Studies date: 2012-03-08 words: 3609 flesch: 19 summary: The focus on molecular methods for respiratory pathogen detection yielded a large variety of potential technologies for consideration in PERCH (Table 1) . Comparative evaluations of respiratory diagnostic assays must also take into account variations in which panel of pathogens is selected, which genetic sequences are targeted, what specimen sources are used [3, 51] , and even what methods are used for nucleic acid extraction [52] . keywords: assay; detection; diagnostic; evaluation; methods; pathogens; pcr; perch; viruses cache: cord-000602-z5p3a64x.txt plain text: cord-000602-z5p3a64x.txt item: #3 of 427 id: cord-000877-usz7pnvu author: Abdel-Moneim, Ahmed S. title: Detection of Bocavirus in Children Suffering from Acute Respiratory Tract Infections in Saudi Arabia date: 2013-01-30 words: 1832 flesch: 48 summary: Swabs samples from 80 children with respiratory tract infections were examined for the presence of HBoV. Real-time polymerase chain reaction was used as a sensitive method to detect the HBoV. Direct gene sequencing was used to determine the genotype of the detected virus isolates. It was then detected in children with respiratory tract infections in addition to gastroenteritis worldwide [9] [10] [11] [12] . keywords: bocavirus; children; hbov; human; infections; tract cache: cord-000877-usz7pnvu.txt plain text: cord-000877-usz7pnvu.txt item: #4 of 427 id: cord-001070-zlzag6a8 author: Camargo, C.N. title: Human rhinovirus infections in symptomatic and asymptomatic subjects date: 2012-06-01 words: 631 flesch: 18 summary: Influenza and rhinovirus infections among health-care workers Acute Respiratory Infection and Influenza-Like Illness Viral Etiologies in Brazilian Adults Respiratory consequences of rhinovirus infection Rhinovirus infections in myelosuppressed adult blood and marrow transplanted recipients Two outbreaks of severe respiratory disease in nursing homes associated with rhinovirus Rhinovirus infections in hematopoietic stem cell transplant recipients with pneumonia Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in children Identification of respiratory viruses in asymptomatic subjects: asymptomatic respiratory viral infections Use of polymerase chain reaction for diagnosis of picornavirus infection in subjects with and without respiratory symptoms Comparison of conventional and molecular detection of respiratory viruses in hematopoietic cell transplant recipients New Vaccine Surveillance Network Rhinovirus-associated hospitalizations in young children Respiratory illness caused by picornavirus infection: a review of clinical outcomes Risk factors for lower respiratory complications of rhinovirus infections in elderly people living in the community: prospective cohort study Human picornavirus and coronavirus RNA in nasopharynx of children without concurrent respiratory symptoms Rhinovirus transmission within families with children: Insidence of symptomatic and assymptomatic infections Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care. IgE and eosinophil analyses Genetic clustering of all 102 human rhinovirus prototype strains: serotype 87 is close to human enterovirus 70 Phylogenetic analysis of rhinovirus isolates collected during successive epidemic seasons Viral respiratory infections in hospitalized and community control children in Alaska Frequent detection of respiratory viruses in adult recipients of stem cell transplants with the use of real-time polymerase chain reaction, compared with viral culture Respiratory pathogens in children with and without respiratory symptoms A rhinovirus outbreak among residents of a long-term care facility All the content of the journal, except where otherwise noted, is licensed under a Creative Commons License We acknowledge Dr. Eurico Arruda (FMRP-USP) for providing HRV 39 isolate. keywords: asymptomatic; infections; rhinovirus cache: cord-001070-zlzag6a8.txt plain text: cord-001070-zlzag6a8.txt item: #5 of 427 id: cord-001162-z8cbbit3 author: Yun, Heather C. title: Pandemic Influenza Virus 2009 H1N1 and Adenovirus in a High Risk Population of Young Adults: Epidemiology, Comparison of Clinical Presentations, and Coinfection date: 2014-01-08 words: 3368 flesch: 34 summary: key: cord-001162-z8cbbit3 authors: Yun, Heather C.; Fugate, William H.; Murray, Clinton K.; Cropper, Thomas L.; Lott, Lisa; McDonald, J. Matthew title: Pandemic Influenza Virus 2009 H1N1 and Adenovirus in a High Risk Population of Young Adults: Epidemiology, Comparison of Clinical Presentations, and Coinfection date: 2014-01-08 journal: PLoS One DOI: 10.1371/journal.pone.0085094 sha: doc_id: 1162 cord_uid: z8cbbit3 BACKGROUND: In 2009, pandemic H1N1 influenza virus (2009 H1N1) emerged worldwide, causing morbidity and mortality that disproportionately affected young adults. Despite high frequencies of adenovirus infection, coinfection with adenovirus and 2009 H1N1 is rare and apparently does not result in increased morbidity. keywords: adenovirus; h1n1; illness; influenza; study; subjects; trainees; training cache: cord-001162-z8cbbit3.txt plain text: cord-001162-z8cbbit3.txt item: #6 of 427 id: cord-002227-x1ddi8wg author: Li, Wanli title: Emergency treatment and nursing of children with severe pneumonia complicated by heart failure and respiratory failure: 10 case reports date: 2016-07-29 words: 4026 flesch: 33 summary: A single-center feasibility study Noninvasive ventilation in children: A review Milrinone combined with dopamine for child pneumonia complicated with heart failure Experimental study of relation of fever to cerebral edema In summary, positive and effective nursing can promote the rehabilitation of children patients, which can be reinforced with adequate communication with the parents and/or caretakers. keywords: blood; children; disease; failure; heart; oxygen; patients; pneumonia; rate; treatment cache: cord-002227-x1ddi8wg.txt plain text: cord-002227-x1ddi8wg.txt item: #7 of 427 id: cord-002590-24o2viv3 author: Rahe, Michael C. title: Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome Virus date: 2017-06-13 words: 8022 flesch: 28 summary: The ability of a pathogen to successfully infect and replicate within innate immune cells makes the development of a protective immune response more difficult. Reorganization and expansion of the nidoviral family Arteriviridae PRRSV, the virus Broadly neutralizing antibodies against the rapidly evolving porcine reproductive and respiratory syndrome virus The ever-expanding diversity of porcine reproductive and respiratory syndrome virus Innate and adaptive immunity against porcine reproductive and respiratory syndrome virus Chimeric porcine reproductive and respiratory syndrome viruses reveal full function of genotype 1 envelope proteins in the backbone of genotype 2 The PRRSV replicase: Exploring the multifunctionality of an intriguing set of nonstructural proteins Current knowledge on the structural proteins of porcine reproductive and respiratory syndrome (PRRS) virus: Comparison of the North American and European isolates Novel structural protein in porcine reproductive and respiratory syndrome virus encoded by an alternative ORF5 present in all arteriviruses Localization and fine mapping of antigenic sites on the nucleocapsid protein N of porcine reproductive and respiratory syndrome virus with monoclonal antibodies Evolutionary diversification of type 2 porcine reproductive and respiratory syndrome virus Porcine reproductive and respiratory syndrome virus: Description of persistence in individual pigs upon experimental infection Porcine reproductive and respiratory syndrome virus (PRRSV): Pathogenesis and interaction with the immune system Porcine reproductive and respiratory syndrome virus infection of gnotobiotic pigs: Sites of virus replication and co-localization with MAC-387 staining at 21 days post-infection Virus quantification and identification of cellular targets in the lungs and lymphoid tissues of pigs at different time intervals after inoculation with porcine reproductive and respiratory syndrome virus (PRRSV) Enhanced replication of porcine reproductive and respiratory syndrome (PRRS) virus in a homogeneous subpopulation of MA-104 cell line Characterization of interaction between porcine reproductive and respiratory syndrome virus and porcine dendritic cells Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus Genetic engineering alveolar macrophages for host resistance to PRRSV Interferon-alpha response to swine arterivirus (PoAV), the porcine reproductive and respiratory syndrome virus Pig immune response to general stimulus and to porcine reproductive and respiratory syndrome virus infection: A meta-analysis approach In vivo and in vitro interferon (IFN) studies with the porcine reproductive and respiratory syndrome virus (PRRSV) Differential production of proinflammatory cytokines in the pig lung during different respiratory virus infections: Correlations with pathogenicity Antigen-specific B-cell responses to porcine reproductive and respiratory syndrome virus infection Porcine reproductive and respiratory syndrome virus utilizes nanotubes for intercellular spread Porcine reproductive and respiratory syndrome virus (PRRSV) infection spreads by cell-to-cell transfer in cultured MARC-145 cells, is dependent on an intact cytoskeleton, and is suppressed by drug-targeting of cell permissiveness to virus infection Schwartz-Cornil, I. Rotavirus anti-VP6 secretory immunoglobulin A contributes to protection via intracellular neutralization but not via immune exclusion Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport The Chinese highly pathogenic porcine reproductive and respiratory syndrome virus infection suppresses Th17 cells response in vivo Thymic depletion of lymphocytes is associated with the virulence of PRRSV-1 strains Identification of apoptotic cells in the thymus of piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus Suppression of NK cell-mediated cytotoxicity against PRRSV-infected porcine alveolar macrophages in vitro The comparative profile of lymphoid cells and the T and B cell spectratype of germ-free piglets infected with viruses SIV, PRRSV or PCV2 Type 2 porcine reproductive and respiratory syndrome virus infection mediated apoptosis in B-and T-cell areas in lymphoid organs of experimentally infected pigs The molecular mechanisms of regulatory T cell immunosuppression. keywords: animals; antibodies; antibody; cells; development; immunity; infection; pigs; porcine; prrsv; response; swine; syndrome; syndrome virus; virus cache: cord-002590-24o2viv3.txt plain text: cord-002590-24o2viv3.txt item: #8 of 427 id: cord-002801-6myqgme3 author: Yoon, Byung Woo title: Possible therapeutic effect of orally administered ribavirin for respiratory syncytial virus-induced acute respiratory distress syndrome in an immunocompetent patient: a case report date: 2017-12-20 words: 2564 flesch: 34 summary: Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis Respiratory syncytial virus infection in recipients of allogeneic stem-cell transplantation: a retrospective study of the incidence, clinical features, and outcome Clinical Practice Guideline of Acute Respiratory Distress Syndrome Acute respiratory distress syndrome: the Berlin Definition Respiratory syncytial virus infection: a cause of respiratory distress syndrome and pneumonia in adults Inhaled ribavirin therapy in adult respiratory syncytial virus-induced acute respiratory distress syndrome Respiratory syncytial virus infection in adults High morbidity and mortality in adults hospitalized for respiratory syncytial virus infections Rapid diagnosis of respiratory syncytial virus infections in immunocompromised adults Multiplex PCR point of care testing versus routine, laboratory-based testing in the treatment of adults with respiratory tract infections: a quasi-randomised study assessing impact on length of stay and antimicrobial use Respiratory Syncytial Virus Infection Control Challenges with a Novel Polymerase Chain Reaction Assay in a Comparison of the AdvanSure real-time RT-PCR and Seeplex(®) RV12 ACE assay for the detection of respiratory viruses Impact of a rapid respiratory panel test on patient outcomes Impact of Early Detection of Respiratory Viruses by Multiplex PCR Assay on Clinical Outcomes in Adult Patients Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature Respiratory viruses other than influenza virus: impact and therapeutic advances Oral ribavirin therapy for lower respiratory tract infection of respiratory syncytial virus complicating bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation Successful treatment of parainfluenza virus 3 pneumonia with oral ribavirin and methylprednisolone in a bone marrow transplant recipient Single-centre experience with oral ribavirin in lung transplant recipients with paramyxovirus infections An 81-year-old Korean man visited our out-patient clinic complaining of cough, dyspnea, and febrile sensation. This case demonstrates the potential usefulness of orally administered ribavirin as a therapeutic option for severe respiratory syncytial virus infection, at least in an immunocompetent host. keywords: case; infection; respiratory; ribavirin; rsv; virus cache: cord-002801-6myqgme3.txt plain text: cord-002801-6myqgme3.txt item: #9 of 427 id: cord-003357-4qrg6lqu author: Wang, Yingchen title: Prevalence of Common Respiratory Viral Infections and Identification of Adenovirus in Hospitalized Adults in Harbin, China 2014 to 2017 date: 2018-11-27 words: 5195 flesch: 39 summary: The etiology of respiratory infection in the adult population has been overlooked, at least in China, although there are plenty of reports on the epidemiology of respiratory viral infection in the pediatric population (Wang et al., 2016) . Viral respiratory infections in the pediatric population from Harbin were reported by the authors' team in 2009 (Zhang et al., 2009) , in which the adult population was not included. keywords: adenovirus; adult; china; detection; harbin; infections; patients; respiratory; virus; viruses cache: cord-003357-4qrg6lqu.txt plain text: cord-003357-4qrg6lqu.txt item: #10 of 427 id: cord-003488-pfzy8p5v author: Cruces, Pablo title: Respiratory mechanics in infants with severe bronchiolitis on controlled mechanical ventilation date: 2017-10-06 words: 3698 flesch: 40 summary: key: cord-003488-pfzy8p5v authors: Cruces, Pablo; González-Dambrauskas, Sebastián; Quilodrán, Julio; Valenzuela, Jorge; Martínez, Javier; Rivero, Natalia; Arias, Pablo; Díaz, Franco title: Respiratory mechanics in infants with severe bronchiolitis on controlled mechanical ventilation date: 2017-10-06 journal: BMC Pulm Med DOI: 10.1186/s12890-017-0475-6 sha: doc_id: 3488 cord_uid: pfzy8p5v BACKGROUND: Analysis of respiratory mechanics during mechanical ventilation (MV) is able to estimate resistive, elastic and inertial components of the working pressure of the respiratory system. Informed consent was waived since respiratory mechanics measurements are part of routine care in the participating PICU's. keywords: bronchiolitis; component; infants; mechanics; patients; pressure; system; working cache: cord-003488-pfzy8p5v.txt plain text: cord-003488-pfzy8p5v.txt item: #11 of 427 id: cord-003492-rodqdtfj author: Montaner-Tarbes, Sergio title: Key Gaps in the Knowledge of the Porcine Respiratory Reproductive Syndrome Virus (PRRSV) date: 2019-02-20 words: 9582 flesch: 17 summary: In vitro comparisons with pulmonary alveolar macrophages (PAMS) Porcine reproductive and respiratory syndrome virus utilizes nanotubes for intercellular spread Effect of malaria on HIV/AIDS transmission and progression Tunneling nanotubes (TNT) are induced by HIV-infection of macrophages: a potential mechanism for intercellular HIV trafficking Tunneling nanotubes as a novel route of cell-to-cell spread of herpesviruses Innate and adaptive immunity against porcine reproductive and respiratory syndrome virus Arterivirus molecular biology and pathogenesis Interferon-stimulated genes: a complex web of host defenses Production of type I interferons: plasmacytoid dendritic cells and beyond Immune responses in pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV) Differential production of proinflammatory cytokines in the pig lung during different respiratory virus infections: Correlations with pathogenicity In vivo and in vitro interferon (IFN) studies with the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Interferon type I response in porcine reproductive and respiratory syndrome virus-infected MARC-145 cells Modulation of innate immune signaling by nonstructural protein 1 (nsp1) in the family Arteriviridae Interplay between interferonmediated innate immunity and porcine reproductive and respiratory syndrome virus Modulation of host cell responses and evasion strategies for porcine reproductive and respiratory syndrome virus Porcine reproductive and respiratory syndrome virus nucleocapsid protein modulates interferon-β production by inhibiting IRF3 activation in immortalized porcine alveolar macrophages The PRRSV replicase: exploring the multifunctionality of an intriguing set of nonstructural proteins Open reading frame 1a-encoded subunits of the arterivirus replicase induce endoplasmic reticulumderived double-membrane vesicles which carry the viral replication complex Porcine alveolar macrophage polarization is involved in inhibition of porcine reproductive and respiratory syndrome virus (PRRSV) replication Porcine reproductive and respiratory syndrome virus nonstructural protein 2 (nsp2) topology and selective isoform integration in artificial membranes The cysteine protease domain of porcine reproductive and respiratory syndrome virus nonstructural protein 2 possesses deubiquitinating and interferon antagonism functions Immunodominant epitopes in nsp2 of porcine reproductive and respiratory syndrome virus are dispensable for replication, but play an important role in modulation of the host immune response Nonstructural protein 11 (nsp11) of porcine reproductive and respiratory syndrome virus (PRRSV) promotes PRRSV infection in MARC-145 cells Nonstructural protein 11 of porcine reproductive and respiratory syndrome virus suppresses both MAVS and RIG-I expression as one of the mechanisms to antagonize type i For example, in respiratory syncytial virus infection, EVs are released with a selected modified cargo when compared with uninfected epithelial cells. keywords: antibodies; cells; ifn; immune; infection; mechanisms; pigs; porcine; proteins; prrsv; replication; response; role; strains; syndrome; syndrome virus; vaccine; virus cache: cord-003492-rodqdtfj.txt plain text: cord-003492-rodqdtfj.txt item: #12 of 427 id: cord-003798-nki2sasr author: Vidaur, Loreto title: Human metapneumovirus as cause of severe community-acquired pneumonia in adults: insights from a ten-year molecular and epidemiological analysis date: 2019-07-24 words: 3506 flesch: 37 summary: In a large prospective study of ICU patients requiring invasive mechanical ventilation, hMPV was more frequently detected in patients admitted by severe respiratory infection than in patients with other causes, suggesting a causal role of HMPV in the development of severe respiratory infection [24] . Bacterial pneumonia Procalcitonin (PCT) levels for ruling-out bacterial coinfection in ICU patients with influenza: a CHAID decision-tree analysis Effect of procalcitonin guided guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the Pro-HOSP randomized controlled trial Procalcitonin guidance of antibiotic therapy in community acquired pneumonia: a randomized trial Towards precision medicine in sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases The role of human Metapneumovirus genetic diversity and nasopharyngeal load on symptom severity in adults LV made substantial contribution to the conception and design of the work, the acquisition, analysis and interpretation of the data and has drafted the work. keywords: hmpv; human; icu; infection; metapneumovirus; patients; pneumonia; study cache: cord-003798-nki2sasr.txt plain text: cord-003798-nki2sasr.txt item: #13 of 427 id: cord-003917-bswndfvk author: Lalle, Eleonora title: Pulmonary Involvement during the Ebola Virus Disease date: 2019-08-24 words: 5546 flesch: 31 summary: A case report Antibody prevalence against haemorrhagic fever viruses in randomized representative Central African populations Risk factors for patients without a reported exposure CDC Centers for Disease Control and Prevention Guidance for Donning and Doffing Personal Protective Equipment (PPE) During Management of Patients with Ebola Virus Disease Interim Infection Prevention and Control Guidance for Care of Patients with Suspected or Confirmed Filovirus Haemorrhagic Fever in Health-Care Settings, with Focus on Ebola Nucleic acid amplification-based diagnosis of respiratory virus infections Understanding Ebola virus transmission Ebola and Marburg virus antibody prevalence in selected populations of the Central African Republic The Repertoire of Adenovirus in Human Disease: The Innocuous to the Deadly Respiratory syncytial virus infection in adults Respiratory syncytial virus Measles virus: Cellular receptors, tropism and pathogenesis Pathological and ultrastructural analysis of surgical lung biopsies in patients with swine-origin influenza type A/H1N1 and acute respiratory failure Pathogenesis of severe acute respiratory syndrome Pathogenesis of the viral hemorrhagic fevers Dengue viruses can infect human primary lung epithelia as well as lung carcinoma cells, and can also induce the secretion of IL-6 and RANTES Pathogenesis of Lassa Fever. Soldier in the Fight against Respiratory Viruses Epithelial antimicrobial peptides and proteins: Their role in host defence and inflammation Centers for Disease Control and Prevention (CDC) CDC Grand Rounds: Discovering new diseases via enhanced partnership between public health and pathology experts Detection of Viral RNA in Tissues following Plasma Clearance from an Ebola Virus Infected Patient Proinflammatory response during Ebola virus infection of primate models: Possible involvement of the tumor necrosis factor receptor superfamily Infection and activation of monocytes by Marburg and Ebola viruses Kinetics of Soluble Mediators of the Host Response in Ebola Virus Disease Human Ebola virus infection results in substantial immune activation Inflammatory and Humoral Immune Response during Ebola Virus Infection in Survivor and Fatal Cases Occurred in Sierra Leone during the 2014-2016 Outbreak in West Africa Into the Eye of the Human fatal zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis Dendritic cells and the control of immunity The lack of maturation of Ebola virus-infected dendritic cells results from the cooperative effect of at least two viral domains Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturation Immune barriers of Ebola virus infection Different features of Vδ2 T and NK cells in fatal and non-fatal human Ebola infections Ebola haemorrhagic fever virus: keywords: cells; disease; ebola; ebov; evd; infection; lung; outbreak; patients; transmission; virus; viruses cache: cord-003917-bswndfvk.txt plain text: cord-003917-bswndfvk.txt item: #14 of 427 id: cord-004397-ypli7wtu author: Ma, Zhan-Ying title: Suspension microarray-based comparison of oropharyngeal swab and bronchoalveolar lavage fluid for pathogen identification in young children hospitalized with respiratory tract infection date: 2020-02-22 words: 3230 flesch: 39 summary: BALF and OPS identified respiratory pathogen infections in 57 (75%) and 49 (64.5%) patients, respectively (P > 0.05). BALF and OPS identified respiratory pathogen infections in 57 (75%) and 49 (64.5%) cases, respectively ( Table 2 ). keywords: balf; children; detection; ops; pathogens; patients; tract cache: cord-004397-ypli7wtu.txt plain text: cord-004397-ypli7wtu.txt item: #15 of 427 id: cord-005583-hmv8jjfl author: Peters, M. J. title: Acute hypoxemic respiratory failure in children: case mix and the utility of respiratory severity indices date: 2013-12-27 words: 3993 flesch: 38 summary: [18] , that other markers sought. of ventilation-related outcome should be Adult respiratory distress syndrome in a pediatric intensive care unit: predisposing conditions, clinical course and outcome Predictors of mortality in children with respiratory failure: possible indications for ECMO Alveolar-arterial oxygen gradient as a predictor of outcome in patients with non-neonatal respiratory failure Mortality rates and prognostic variables in children with adult respiratory distress syndrome Adult respiratory distress syndrome in children: associated diseases, clinical course and predictors of death Fackler JC and the Pediatric Critical Care Study Group and the Extracorporeal Life Support Organisation (1995) Predicting death in pediatric patients with acute respiratory failure Acute respiratory distress syndrome caused by respiratory syncytial virus Early response to inhaled nitric oxide and its relationship to outcome in children with severe hypoxemic respiratory failure Predicting outcome in children with severe acute respiratory failure treated with high-frequency ventilation The American-European consensus conference on ARDS: Definitions, mechanisms, relevant outcomes and clinicai trial coordination Outcome of pediatric patients with multiple organ system failure Arterial oxygenation does not predict the outcome of patients with acute respiratory failure needing mechanical ventilation Is outcome from ARDS related to the severity of respiratory failure? Outcome from mechanical ventilation PRISM III: An updated pediatric risk of mortality score Wilkinson K (1997) keywords: ahrf; care; children; failure; mortality; outcome; patients; study cache: cord-005583-hmv8jjfl.txt plain text: cord-005583-hmv8jjfl.txt item: #16 of 427 id: cord-005646-xhx9pzhj author: None title: 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date: 1996 words: 72090 flesch: 51 summary: Objective: To assess the normal ,gastric intramucosal pH ~Hi) by tonometry in healthy children Patients and methods: Twelve healthy children (6 males and 6 females) with age rmaged from 6 months to 12 years scheduled for minor plastic or urologic surgery. Pain relief was good (VRS less 2) in 53 children -94.6 % of study patients. keywords: acute; administration; admission; age; airway; analysis; ards; arterial; average; babies; blood; brain; cardiac; care; cases; changes; chest; children; complications; conclusion; cpb; criteria; data; days; death; diagnosis; difference; disease; dose; drug; duration; ecmo; effects; failure; flow; gas; group; heart; high; hospital; hours; hypertension; icu; ill; incidence; increase; infants; infusion; initial; injury; intensive; levels; life; lung; management; mean; measurements; mechanical; median; medical; methods; minutes; months; mortality; neonatal; neonates; newborns; nitric; non; nurses; outcome; oxide; oxygenation; parameters; patients; peak; pediatric; period; phi; picu; plasma; post; present; pressure; prism; pulmonary; range; rate; response; results; risk; score; sepsis; severe; severity; study; support; surgery; survivors; syndrome; system; test; therapy; time; total; treatment; unit; use; values; ventilation; volume; weeks; weight; years cache: cord-005646-xhx9pzhj.txt plain text: cord-005646-xhx9pzhj.txt item: #17 of 427 id: cord-005774-7z6uyn6p author: Hammer, J. title: Infant lung function testing in the intensive care unit date: 1995 words: 5009 flesch: 42 summary: Although the most fundamental interest in lung volume measurements in infancy and childhood relates to the assessment of normal and abnormal lung growth [47, 48], the determination of lung volumes is an important part of the respiratory management of infants and children [49] . Lung volume measurements can help in diagnosing respiratory disorders, in evaluating responses to therapy, and in finding suitable ventilator settings with respect to rate and ventilating pressures [50-52]. keywords: breathing; children; disease; flow; infants; lung; pressure; technique; time; volume cache: cord-005774-7z6uyn6p.txt plain text: cord-005774-7z6uyn6p.txt item: #18 of 427 id: cord-005814-ak5pq312 author: None title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 words: 179325 flesch: 51 summary: Leukemia inhibitory factor (LIF), a growth factor recently recognised as a polyfunctional cytokine integrated in cytokine networks was measured in unconcentrated BALF of patients from different patient groups. It is difficult to generalize on intensive care units as different patient groups are in different ICUs aud there are great changes from one hospital to another and from one country to another. keywords: activity; acute; administration; admission; adult patients; age; aim; airway; analysis; apache; application; ards patients; arf; arterial; artery; assess; average; baseline; blood; blood flow; blood pressure; blood volume; breathing; cardiac; care patients; care unit; cases; catheter; cerebral; changes; chest; children; clinical; compliance; complications; concentration; conclusions; conditions; constant; control group; control patients; copd patients; correlation; course; cpb; criteria; critical; cvp; daily; damage; data; days; death; death patients; decrease; diagnosis; difference; disease; dose; drugs; duration; dysfunction; effect; emergency; end; evaluation; exchange; factors; failure; failure patients; findings; flow; fluid; following; frequency; function; gas; gastric; general; good; group; group b; group ii; group patients; h20; head; heart; hemodynamic; hepatic; hospital; hours; hypertension; icp; icu patients; iii; ill; illness; improvement; incidence; increase; index; infection; influence; infusion; injury; intensive; introduction; intubation; lactate; left; levels; life; liver; lung; male; management; map; mean; measurements; median; medical; methods; min; minutes; mmhg; model; monitoring; mortality; mortality rate; muscle; myocardial; need; negative; new; non; normal; number; objectives; onset; operation; order; organ; outcome; output; oxygen; oxygenation; p =; p<0.05; pao2; parameters; patients; patients methods; pattern; peep; perfusion; period; phase; phi; plasma; population; position; postoperative; presence; present; pressure; pressure support; procedure; protocol; pts; pulmonary; rain; range; rate; rats; reduction; renal; resistance; respiratory; response; results; right; risk; risk patients; samples; saps; score; sepsis; septic; serum; severe; severity; shock; shock patients; signs; specific; standard; status; stay; studies; study; study group; study period; subjects; support; surgery patients; surgical; survival; survivors; syndrome; system; systemic; technique; temperature; test; therapeutic; therapy; time; tissue; total; tracheal; transplantation; trauma patients; treatment; tube; type; unit; university; use; values; variables; vascular; vein; venous; ventilation; ventricular; volume; weaning; years cache: cord-005814-ak5pq312.txt plain text: cord-005814-ak5pq312.txt item: #19 of 427 id: cord-005818-3mzwliiy author: Speer, C. P. title: Surfactantsubstitutionstherapie: Ein entscheidender Durchbruch in der Behandlung des Atemnotsyndroms Frühgeborener date: 2014-04-24 words: 3933 flesch: 17 summary: Es gibt einige Hinweise, dass eine Surfactanttherapie auch bei pulmonalen Erkrankungen Neugeborener einen therapeutischen Effekt haben kann; diese Erkrankungen wie Mekoniumaspirationssyndrom und neonatale Pneumonie führen u.a.über eine Inaktivierung von Surfactant zu einer sekundären Defizienz dieses oberflächenaktiven Systems. Surfactant therapy and CPAP reduce the need of respiratory support Comparison of Infasurf (calf lung surfactant extract) to Survanta (Beractant) in the treatment and prevention of respiratory distress syndrome Surfactant proteins and anti-surfactant antibodies in sera from infants with respiratory distress syndrome with and without surfactant treatment The efficacy and safety of KL 4 -surfactant in preterm infants with respiratory distress syndrome Future surfactant preparations Surfactant replacement therapy: An update on applications Surfactant replacement therapy: prophylaxis or treatment? Theoretical changes in neonatal hospitalisation costs after the introduction of porcine-derived lung surfactant (Curosurf®) Mortality, severe respiratory distress syndrome, and chronic lung disease of the newborn are reduced more after prophylactic than after therapeutic administration of the surfactant Curosurf Lung expansion in the premature rabbit fetus after tracheal deposition of surfactant Survival and follow-up of infants born at 23 to 26 weeks of gestational age: effects of surfactant therapy Surfactant replacement therapy for meconium aspiration syndrome Nebulisation of surfactants in an animal model of neonatal respiratory distress Artificial surfactant therapy in hyaline-membrane disease High-dose versus low-dose bovine surfactant treatment in very premature infants Early versus late surfactant treatment in preterm infants of 27 to 32 weeks of gestational age: a multicenter controlled clinical trial Pulmonale Alveolarproteinosen -Molekulare Grundlagen und Konsequenzen für Diagnostik und Therapie Effects of rSP-C surfactant on oxygenation and histology in a rat-lung-lavage model of acute lung injury Follow up data from babies treated with surfactant Phospholipidkonzentration: 2,5 mg/ml) in Abhängigkeit von der zugesetzten Mekoniumkonzentration. keywords: auf; behandlung; bei; curosurf; dass; der; des; die; distress; durch; eine; frühgeborenen; infants; mit; nach; neonatal; nicht; rds; sich; studien; surfactant; syndrome; therapy; treatment; und; von; werden; wurde cache: cord-005818-3mzwliiy.txt plain text: cord-005818-3mzwliiy.txt item: #20 of 427 id: cord-006261-yw5k8qkz author: Heath, Gregory W. title: Exercise and Upper Respiratory Tract Infections: Is There a Relationship? date: 2012-10-23 words: 6219 flesch: 34 summary: Despite these beliefs, few studies have examined the relationships that exist among exercise and clinical expressions of upper respiratory tract infections. This article seeks to examine the existing studies that have investigated the relationship between exercise and upper respiratory tract infections and to determine ifany such relationship exists. keywords: activity; et al; exercise; increase; infections; lymphocyte; nieman; respiratory; studies; symptoms; tract; training cache: cord-006261-yw5k8qkz.txt plain text: cord-006261-yw5k8qkz.txt item: #21 of 427 id: cord-006325-3no74e74 author: Jeannoël, M. title: Microorganisms associated with respiratory syncytial virus pneumonia in the adult population date: 2018-10-23 words: 1956 flesch: 35 summary: A more severe outcome was observed for RSV-bacteria-associated pneumonia compared with RSV pneumonia: length of stay was significantly longer (16 days vs 10 days) and ICU hospitalization more frequent (66.7% vs 21.0%) The aim of our study was to gain insights in the epidemiology of bacterial superinfections associated with RSV pneumonia in adults. keywords: adults; bacteria; patients; pneumonia; rsv cache: cord-006325-3no74e74.txt plain text: cord-006325-3no74e74.txt item: #22 of 427 id: cord-007030-mewo9w43 author: Hashim, Suhana title: The prevalence and preventive measures of the respiratory illness among Malaysian pilgrims in 2013 hajj season date: 2016-02-08 words: 3905 flesch: 49 summary: Respiratory illness continues to exert a burden on hajj pilgrims in Makkah. 5 A recent study involving Malaysian hajj pilgrims found that 90% of them had at least one respiratory symptom. keywords: hajj; hand; illness; influenza; pilgrims; study; symptoms cache: cord-007030-mewo9w43.txt plain text: cord-007030-mewo9w43.txt item: #23 of 427 id: cord-007176-61e9obb3 author: Jackson, George Gee title: Viroses Causing Common Respiratory Infections in Man. III. Respiratory Syncytial Viroses and Coronavimses date: 1973-11-17 words: 4091 flesch: 47 summary: 3. Clinical and laboratory findings Morphology and development of respiratory syncytial virus in cell culture Growth and serologic characteristics of respiratory syncytial virus Respiratory syncytial virus Experimental cytial virus antigens by agar gel diffusion and immunoelectrophoresis Interferon and respiratory syncytial virus Speculation on pathogenesis in death from respiratory syncytial virus infection The late detection of respiratory syncytial virus in cells of respiratory tract by immunofluorescence Double infection with RS virus and influenza Virus infections in children. Clinical comparison of overlapping outbreaks of influenza A2-Hong Kong-68 and respiratory syncytial virus infections Differentiation of actively and passively acquired complementfixing antibodies in infants with respiratory syncytial virus infection The use of cough-nasal swabs in the rapid diagnosis of respiratory syncytial virus infection by the fluorescent antibody technique Morphogenesis of respiratory syncytial virus in a green monkey kidney cell line (Vero) Respiratory syncytial virus neutralizing activity in nasopharyngeal secretions RSV infections and infant deaths Respiratory syncytial virus tissue culture immunofluorescence as a laboratory aid Rapid diagnosis of respiratory syncytial virus infection in children by the immunofluorescent technique Experimental respiratory syncytial virus infection of adults. keywords: 229e; antibody; coronavirus; infection; respiratory; strain; syncytial; virus cache: cord-007176-61e9obb3.txt plain text: cord-007176-61e9obb3.txt item: #24 of 427 id: cord-007222-31o180fz author: MUFSON, MAURICE A. title: EPIDEMIOLOGY OF RESPIRATORY SYNCYTIAL VIRUS INFECTION AMONG INFANTS AND CHILDREN IN CHICAGO date: 1973-08-17 words: 2729 flesch: 45 summary: Respiratory syncytial virus epidemics occurred annually and were temporally synchronous with the peak periods of respiratory disease admissions. The peak months of respiratory syncytial virus epidemics were December 1966, January 1968, February-March 1969, April 1970 and January 1971. keywords: children; disease; epidemics; rsv; tract; virus cache: cord-007222-31o180fz.txt plain text: cord-007222-31o180fz.txt item: #25 of 427 id: cord-007234-hcpa8ej5 author: Renwick, Neil title: A Recently Identified Rhinovirus Genotype Is Associated with Severe Respiratory-Tract Infection in Children in Germany date: 2007-12-15 words: 2515 flesch: 31 summary: Frequency and natural history of rhinovirus infections in adults during autumn Viruses and bacteria in the etiology of the common cold The seasonality of rhinovirus infections and its implications for clinical recognition Characterization and classification of ECHO 28-rhinovirus-coryzavirus agents Detection of rhinovirus RNA in lower airway cells during experimentally induced infection Rhinoviruses infect the lower airways Quantitative and qualitative analysis of rhinovirus infection in bronchial tissues Rhinovirus and the lower respiratory tract Interleukin-10 gene expression in acute virus-induced asthma Rhinovirus viremia in children with respiratory infections Viral infections of human Association of rhinovirus infection with increased disease severity in acute bronchiolitis International Committee on Taxonomy of Viruses. Universal Database of the International Committee on Taxonomy of Viruses Virus taxonomy: eighth report of the International Committee on Taxonomy of Viruses Antigenic groupings of 90 rhinovirus serotypes A collaborative report: rhinoviruses-extension of the numbering system from 89 to 100 Two groups of rhinoviruses revealed by a panel of antiviral compounds present sequence divergence and differential pathogenicity Alignment of capsid protein VP1 sequences of all human rhinovirus prototype strains: conserved motifs and functional domains Molecular relationships between 21 human rhinovirus serotypes Genetic clustering of all 102 human rhinovirus prototype strains: serotype 87 is close to human enterovirus 70 Many rhinovirus serotypes share the same cellular receptor The major and minor group receptor families contain all but one human rhinovirus serotype Human rhinovirus 87 and enterovirus 68 represent a unique serotype with rhinovirus and enterovirus features VP1 sequencing of all human rhinovirus serotypes: insights into genus phylogeny and susceptibility to antiviral capsid-binding compounds Rapid simultaneous diagnosis of infections with respiratory syncytial viruses A and B, influenza viruses A and B, and human parainfluenza virus types 1, 2, and 3 by multiplex quantitative reverse transcription-polymerase chain reaction-enzyme hybridization assay (Hexaplex) GeneScan reverse transcription-PCR assay for detection of six common respiratory viruses in young children hospitalized with acute respiratory illness Diagnostic system for rapid and sensitive differential detection of pathogens Microarray-based detection and genotyping of viral pathogens Panmicrobial oligonucleotide array for diagnosis of infectious diseases MassTag polymerase-chainreaction detection of respiratory pathogens, including a new rhinovirus genotype, that caused influeza-like illness in New York State during Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult Improved detection of rhinoviruses in nasal and throat swabs by seminested RT-PCR Molecular diagnosis of human rhinovirus infections: comparison with virus isolation Detection of rhinoviruses by tissue culture and two independent amplification techniques, nucleic acid sequence-based amplification and reverse transcription-PCR, in children with acute respiratory infections during a winter season Picornavirus infections in children diagnosed by RT-PCR during longitudinal surveillance with weekly sampling: association with symptomatic illness and effect of season Application of a fluorogenic PCR assay for typing and subtyping of influenza viruses in respiratory samples Simultaneous detection of fourteen respiratory viruses in clinical specimens by two multiplex reverse transcription nested-PCR assays MEGA3: integrated software for molecular evolutionary genetics analysis and sequence alignment Use of polymerase chain reaction for diagnosis of picornavirus infection in subjects with and without respiratory symptoms Human picornavirus and coronavirus RNA in nasopharynx of children without concurrent respiratory symptoms Novel Rhinovirus Genotype in LRTI • JID Respiratory picornaviruses and respiratory syncytial virus as causative agents of acute expiratory wheezing in children Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care: IgE and eosinophil analyses Rhinovirus-associated hospitalizations in young children Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in children Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects Low grade rhinovirus infection induces a prolonged release of IL-8 in pulmonary epithelium Rhinovirus replication causes RANTES production in primary bronchial epithelial cells Rhinovirus infection increases 5-lipoxygenase and cyclooxygenase-2 in bronchial biopsy specimens from nonatopic subjects Rhinovirus infections in an industrial population. keywords: children; hrv; human; infections; pcr; rhinovirus; viruses cache: cord-007234-hcpa8ej5.txt plain text: cord-007234-hcpa8ej5.txt item: #26 of 427 id: cord-007417-az8xd66p author: Hansbro, Nicole G. title: Understanding the mechanisms of viral induced asthma: New therapeutic directions date: 2008-01-29 words: 29711 flesch: 30 summary: Synergistic suppression of virus-induced chemokines in airway epithelial cells The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus Interleukin-11: Stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness Spectrum of clinical illness in hospitalized patients with common cold virus infections Efficacy of a saponin-adjuvanted inactivated respiratory syncytial virus vaccine in calves Response of calves to challenge exposure with virulent bovine respiratory syncytial virus following intranasal administration of vaccines formulated for parenteral administration Respiratory syncytial virus infection in immunocompromised adults Vascular endothelial growth factor induces endothelial fenestrations in vitro The role of the respiratory syncytial virus in airway syndromes in childhood The relationship between respiratory syncytial virus infections and the development of wheezing and asthma in children Suppression of pattern-recognition receptor TLR4 sensing does not alter lung responses to pneumovirus infection Relationship of serum antibody to risk of respiratory syncytial virus infection in elderly adults Respiratory syncytial virus infection in elderly and high-risk adults Increased vascular endothelial growth factor and receptors: Relationship to angiogenesis in asthma Macrolides in the treatment of asthma and cystic fibrosis Doubling the dose of budesonide versus maintenance treatment in asthma exacerbations Acute bronchiolitis in infancy as risk factor for wheezing and reduced pulmonary function by seven years in Akershus County Respiratory illness associated with influenza and respiratory syncytial virus infection Respiratory syncytial virus infection: Its role in aeroallergen sensitization during the first two years of life Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects Detection of viral, Chlamydia pneumoniae and Mycoplasma pneumoniae infections in exacerbations of asthma in children Transcriptional activation of the interleukin-8 gene by respiratory syncytial virus infection in alveolar epithelial cells: Nuclear translocation of the RelA transcription factor as a mechanism producing airway mucosal inflammation Macrophage inflammatory protein-1alpha (not T helper type 2 cytokines) is associated with severe forms of respiratory syncytial virus bronchiolitis A comparison of epidemiologic and immunologic features of bronchiolitis caused by influenza virus and respiratory syncytial virus Intracellular pool of vascular endothelial growth factor in human neutrophils Impaired virus-induced interferon-alpha2 release in adult asthmatic patients Relationship of upper and lower airway cytokines to outcome of experimental rhinovirus infection Relationships among specific viral pathogens, virus-induced interleukin-8, and respiratory symptoms in infancy Double-stranded RNA induces the synthesis of specific chemokines by bronchial epithelial cells Effects of viral respiratory infections on lung development and childhood asthma Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life A bovine model of vaccine enhanced respiratory syncytial virus pathophysiology Rhinovirus infects primary human airway fibroblasts and induces a neutrophil chemokine and a permeability factor Mobilization of plasmacytoid and myeloid dendritic cells to mucosal sites in children with respiratory syncytial virus and other viral respiratory infections 543â��546. A prospective cohort study with matched controls Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13 Subgroup specific protection of mice from respiratory syncytial virus infection with peptides encompassing the amino acid region 174-187 from the G glycoprotein: The role of cysteinyl residues in protection Impact of severe disease caused by respiratory syncytial virus in children living in developed countries Palivizumab prophylaxis, respiratory syncytial virus, and subsequent recurrent wheezing Clinical and immunological effects of low-dose IFN-alpha treatment in patients with corticosteroid-resistant asthma Inflammatory subtypes in asthma: assessment and identification using induced sputum Sequelae of severe respiratory syncytial virus infection in infancy and early childhood among Alaska Native children Childhood asthma following hospitalization with acute viral bronchiolitis in infancy Role of monocytes and eosinophils in human respiratory syncytial virus infection in vitro Suppression of the induction of alpha, beta, and lambda interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages Effects of nonstructural proteins NS1 and NS2 of human respiratory syncytial virus on interferon regulatory factor 3, NF-kappaB, and proinflammatory cytokines Tolerance and efficacy of intranasal administration of recombinant beta serine interferon in healthy adults Virus-specific CD8+ T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection Virus-specific memory and effector T lymphocytes exhibit different cytokine responses to antigens during experimental murine respiratory syncytial virus infection Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years Atopic disposition, wheezing, and subsequent respiratory syncytial virus hospitalization in Danish children younger than 18 months: A nested case-control study A survey of virus infections of the respiratory tract of cattle and their association with disease Family size, infection and atopy: The first decade of the hygiene hypothesis Infection of a human respiratory epithelial cell line with rhinovirus. keywords: acute; ahr; airway; asthma; bronchiolitis; cd8; cells; children; development; disease; effects; et al; human; ifn; immune; induces; infection; inflammation; inflammatory; life; lung; mice; protein; release; responses; rhinovirus; role; rsv; rsv infection; studies; symptoms; syncytial; th1; th2; virus; virus infection; wheezing cache: cord-007417-az8xd66p.txt plain text: cord-007417-az8xd66p.txt item: #27 of 427 id: cord-007445-2folsh35 author: Tuffaha, Amjad title: THE ROLE OF RESPIRATORY VIRUSES IN ACUTE AND CHRONIC ASTHMA date: 2000-06-01 words: 4973 flesch: 20 summary: Respiratory virus infections usually cause peripheral lymphopenia and increased numbers of lymphocytes in the upper and lower airways, for example. Respiratory syncytial virus infections may interact with immunoinflammatory mechanisms involved in immediate hypersensitivity responses in a number of ways.18 First, it has been suggested that viruses capable of infecting lower airway epithelium may lead to enhanced absorption of aeroallergens across the airway wall, predisposing to subsequent sensitizati~n.~~, 94 Second, RSV-specific IgE antibody formation may lead to mast-cellmediator release within the airway, resulting in the development of bronchospasm and the ingress of eo~inophils.~~, 60, 85, 115 Respiratory syncytial virus belongs to the family Paramyxoviridae, the genera Pneumovirus, and can be differentiated into two serologic subgroups, A and B.M, It has 10 genes, with 12 potential gene products. keywords: airway; asthma; cells; children; development; infection; rsv; symptoms; virus; viruses; wheezing cache: cord-007445-2folsh35.txt plain text: cord-007445-2folsh35.txt item: #28 of 427 id: cord-007796-zggk0x2q author: Lindemans, Caroline A. title: The Immune Response to Viral Lower Respiratory Tract Infection date: 2005 words: 9805 flesch: 32 summary: Predictive value for subsequent development of persistent wheezing Are we ready for universal influenza vaccination in paediatrics? Concurrent serious bacterial infections in 2396 infants and children hospitalized with respiratory syncytial virus lower respiratory tract infections Specific inhibition of type I interferon signal transduction by respiratory syncytial virus Viral evolution toward change in receptor usage: Adaptation of a major group human rhinovirus to grow in ICAM-1-negative cells Eosinophils, eosinophil ribonucleases, and their role in host defense against respiratory virus pathogens Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen Latency and persistence of respiratory syncytial virus despite T cell immunity IFNgamma mediates a novel antiviral activity through dynamic modulation of TRAIL and TRAIL receptor expression Viral infections in obstructive airway diseases Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7 How viruses enter animal cells Respiratory syncytial virus bronchiolitis: Disease severity, interleukin-8, and virus genotype Respiratory virus infections in the immunocompromised host Suppression of the induction of alpha, beta, and gamma interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years Respiratory syncytial virus epidemics: The ups and downs of a seasonal virus Respiratory syncytial virus enhances the expression of CD11b molecules and the generation of superoxide anion by human eosinophils primed with platelet-activating factor Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease Time course of severe respiratory syncytial virus infection in mechanically ventilated infants Palivizumab, a humanized respiratory syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants Respiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathway Identification of NF-kappaB-dependent gene networks in respiratory syncytial virus-infected cells CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein Respiratory syncytial virus infection in patients with phagocyte defects A newly discovered human pneumovirus isolated from young children with respiratory tract disease An update on the pathophysiology of rhinovirus upper respiratory tract infections Viral lower respiratory tract infection in infants and young children Replication and clearance of respiratory syncytial virus: Apoptosis is an important pathway of virus clearance after experimental infection with bovine respiratory syncytial virus Viral induction of a chronic asthma phenotype and genetic segregation from the acute response The interaction of neutrophils with respiratory epithelial cells in viral infection Respiratory syncytial virus-specific antibody responses in immunoglobulin A and E isotypes to the F and G proteins and to intact virus after natural infection Community respiratory viruses: Organ transplant recipients Respiratory outcomes in high-risk children 7 to 10 years after prophylaxis with respiratory syncytial virus immune globulin Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children Immune responses to adenoviruses: Viral evasion mechanisms and their implications for the clinic Paramyxoviridae use distinct virusspecific mechanisms to circumvent the interferon response Evidence of airborne transmission of the severe acute respiratory syndrome virus Contribution of influenza and respiratory syncytial virus to community cases of influenza-like illness: An observational study Impaired innate host defense causes susceptibility to respiratory virus infections in cystic fibrosis is likely to be crucial to the improvement of immunotherapies for prevention and treatment of viral respiratory tract infections. In solid organ transplant patients, respiratory virus infections are also associated with a higher incidence of rejection (Wendt, 1997) . keywords: asthma; bronchiolitis; cells; children; disease; epithelial; et al; human; infection; protein; receptor; response; rhinovirus; rsv; tract; viral; virus; viruses cache: cord-007796-zggk0x2q.txt plain text: cord-007796-zggk0x2q.txt item: #29 of 427 id: cord-008716-38sqkh9m author: Schmidt, Alexander C title: Current research on respiratory viral infections: Third International Symposium date: 2001-06-01 words: 24777 flesch: 38 summary: I. Isolation, properties and characterization Newly recognized myxoviruses from children with respiratory disease Growth on artificial medium of an agent associated with atypical pneumonia and its identification as PPLO Isolation and characterization of adenovirus 5 from the brain of an infant with fatal cerebral edema Respiratory viruses interfere with bacteriologic response to antibiotic in children with acute otitis media Parainfluenza Viruses Rational design of live-attenuated recombinant vaccine virus for human respiratory syncytial virus by reverse genetics Production of infectious human respiratory syncytial virus from cloned cDNA confirms an essential role for the transcription elongation factor from the 5% proximal open reading frame of the M2 mRNA in gene expression and provides a capability for vaccine development Recovery of viruses other than cytomegalovirus from bronchoalveolar lavage fluid Immunity to influenza in man Immunization of types four and seven adenoviruses by selective infection of the intestinal tract Respiratory viral infections in immunocompetent and immunocompromised persons Host responses to respiratory virus infection and immunization Satisfactorily attenuated and protective mutants derived from a partially attenuated cold-passaged respiratory syncytial virus mutant by introduction of additional attenuating mutations during chemical mutagenesis Recombinant human respiratory syncytial virus (RSV) monoclonal antibody Fab is effective therapeutically when introduced directly into the lungs of RSV-infected mice The molecular basis of pneumococcal infection: a hypothesis Rehospitalization for respiratory illness in infants of less than 32 weeks' gestation Acute respiratory viral infections in ambulatory children of urban northeast Brazil Heparan sulfate glycosaminoglycans are involved in adenovirus type 5 and 2-host cell interactions Comparison of rapid diagnostic techniques for respiratory syncytial and influenza A virus respiratory infections in young children Human parainfluenza virus type 3 (PIV3) expressing the hemagglutinin protein of measles virus provides a potential method for immunization against measles virus and PIV3 in early infancy Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes Rapid diagnosis of respiratory syncytial virus infections in immunocompromised adults Mechanism of protective immunity against influenza virus infection in mice without antibodies Efficacy of a Pneumococcal Conjugate Vaccine against Acute Otitis Media. Respiratory virus infections in immunocompromised patients are characterized by persistence of viral infection, prolonged shedding of virus, a high rate of nosocomial acquisition, and a high frequency of pneumonia and death. keywords: adenovirus; adults; age; antibody; cell; children; clinical; day; development; disease; et al; group; human; infants; infected; infection; influenza; influenza virus; mice; pandemic; patients; protein; respiratory; risk; rsv; rsv disease; rsv vaccine; study; syncytial; time; tract; treatment; vaccine; viral; virus; virus infection; viruses; years cache: cord-008716-38sqkh9m.txt plain text: cord-008716-38sqkh9m.txt item: #30 of 427 id: cord-009860-qebenhxz author: Falsey, Ann R. title: Viral Respiratory Infections in the Institutionalized Elderly: Clinical and Epidemiologic Findings date: 2015-04-27 words: 3472 flesch: 48 summary: The A frequency of respiratory infections is high in young children and appears to decline with advancing age.' Residents of long-term-care facilities represent a debilitated subgroup of the elderly population and thus are particularly prone to excess morbidity with respiratory infections. keywords: illness; infection; influenza; patients; rsv; study; virus cache: cord-009860-qebenhxz.txt plain text: cord-009860-qebenhxz.txt item: #31 of 427 id: cord-010233-772e35kx author: Monto, Arnold S. title: Respiratory illness caused by picornavirus infection: a review of clinical outcomes date: 2002-01-03 words: 4599 flesch: 30 summary: The search terms used were picornavirus, rhinovirus, enterovirus, viral respiratory infection, upper respiratory infection, disease burden, economic, cost, complications, asthma, COPD, immunocompromised, elderly, otitis media, and sinusitis. Younger children appear to be more susceptible to viral respiratory infections, as demonstrated by the fact that preschool children can have 5 to 9 respiratory infections per year. keywords: asthma; children; infections; patients; picornavirus; rhinovirus; study; tract cache: cord-010233-772e35kx.txt plain text: cord-010233-772e35kx.txt item: #32 of 427 id: cord-010368-plpghewn author: Kenmoe, Sebastien title: Association of early viral lower respiratory infections and subsequent development of atopy, a systematic review and meta-analysis of cohort studies date: 2020-04-24 words: 3927 flesch: 35 summary: Included studies were prospective and retrospective cohorts with a minimum follow-up duration of one year. In accordance with Newcastle-Ottawa Scale (NOS) criteria including patient selection, comparability of groups, and outcome evaluation, two independent researchers (KS and AFM) assessed the quality of all included studies [26] (S2 Table) . keywords: atopy; development; lrti; review; serum; studies; years cache: cord-010368-plpghewn.txt plain text: cord-010368-plpghewn.txt item: #33 of 427 id: cord-011095-79ce5900 author: Meskill, Sarah D. title: Respiratory Virus Co-infection in Acute Respiratory Infections in Children date: 2020-01-24 words: 4979 flesch: 27 summary: mSphere Respiratory pathogens in children with and without respiratory symptoms Clinical utility of PCR for common viruses in acute respiratory illness Rates of asymptomatic respiratory virus infection across age groups Respiratory syncytial virus: infection, detection, and new options for prevention and treatment The burden of respiratory syncytial virus infection in young children Community-acquired pneumonia requiring hospitalization among U.S. children Human rhinoviruses Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis Insights into the interaction between influenza virus and pneumococcus Preventing and treating influenza Quantitative review of antibody response to inactivated seasonal influenza vaccines. Of those participants who tested negative for respiratory viral infections, 81.9-99.6% reported to be asymptomatic depending on the definition applied. keywords: children; disease; infections; influenza; patients; rsv; study; virus; viruses cache: cord-011095-79ce5900.txt plain text: cord-011095-79ce5900.txt item: #34 of 427 id: cord-015893-e0fofgxq author: Ryhal, Bruce title: Viral Disease, Air Pollutants, Nanoparticles, and Asthma date: 2011-05-03 words: 6332 flesch: 43 summary: The causal direction in the association between respiratory syncytial virus hospitalization and asthma Evidence of a causal role of winter virus infection during infancy in early childhood asthma The effect of respiratory syncytial virus on subsequent recurrent wheezing in atopic and nonatopic children Siblings, day-care attendance, and the risk of asthma and wheezing during childhood Day-care attendance, position in sibship, and early childhood wheezing: A population-based birth cohort study Day care, siblings, and asthma-Please, sneeze on my child A novel group of rhinoviruses is associated with asthma hospitalizations Association between human rhinovirus and severity of acute asthma in children Effects of allergic inflammation of the nasal mucosa on the severity of rhinovirus 16 cold Oral prednisolone for preschool children with acute virus-induced wheezing The Asthma Predictive Index: A very useful tool for predicting asthma in young children Preemptive use of high-dose fluticasone for virus induced wheezing in young children Montelukast reduces asthma exacerbations in 2-to 5-year-old children with intermittent asthma Computed tomographic study of the common cold Effect of amoxicillin-clavulanate in clinically diagnosed acute rhinosinusitis Antibiotics for acute maxillary sinusitis Cluster analysis and clinical asthma phenotypes Infectious asthma: a reemerging clinical entity? Epidemiology of asthma exacerbations A cluster analysis divided asthma patients into five different groups. keywords: air; asthma; children; disease; hrv; illness; infection; patients; pollution; respiratory; study; wheezing cache: cord-015893-e0fofgxq.txt plain text: cord-015893-e0fofgxq.txt item: #35 of 427 id: cord-016009-qa7bcsbu author: Starkel, Julie L. title: Respiratory date: 2019-10-07 words: 22281 flesch: 42 summary: In Europe, lung disease represents 15% of all deaths -the fourth leading cause. Added together, lung disease rivals the position for the top cause of death. keywords: acid; antioxidant; asthma; body; cancer; cells; children; chronic; copd; deficiency; diet; disease; exposure; fibrosis; function; glutathione; health; immune; inflammation; intake; iron; levels; liver; low; lung; lung cancer; lung disease; patients; pulmonary; research; risk; role; status; stress; study; symptoms; tissue; treatment; vitamin cache: cord-016009-qa7bcsbu.txt plain text: cord-016009-qa7bcsbu.txt item: #36 of 427 id: cord-016020-awanrm9u author: Fox, Julie D. title: Respiratory Pathogens date: 2007 words: 4604 flesch: 22 summary: Future directions will incorporate the use of microarray systems for respiratory pathogen detection and analysis to allow crossing of the barriers between conventional virology and bacteriology (and mycology/parasitology). For respiratory viruses, other methods have been used for typing, including heteroduplex mobility assay (HMA), single-strand conformation polymorphism (SSCP), and RFLP analysis of amplified PCR products. keywords: amplification; analysis; detection; diagnosis; infections; influenza; methods; pathogens; pcr; viruses cache: cord-016020-awanrm9u.txt plain text: cord-016020-awanrm9u.txt item: #37 of 427 id: cord-016070-e9ix35x3 author: Perret Pérez, Cecilia title: Pneumonia Caused by Emerging Viral Agents date: 2020-02-01 words: 3647 flesch: 41 summary: This virus is detected in up to 10% of acute respiratory disease cases, and its symptoms range from upper respiratory disease, including flu-like disease, fever, rhinitis, odynophagia, and cough, to serious conditions with a rapidly progressing respiratory disease. Coronavirus NL 63, which belongs to coronavirus group I, was discovered for the first time in a child with bronchiolitis in the Netherlands in 2004, and then ratified in small children hospitalized for serious respiratory infections. keywords: cases; children; coronavirus; disease; human; infection; influenza; patients; virus cache: cord-016070-e9ix35x3.txt plain text: cord-016070-e9ix35x3.txt item: #38 of 427 id: cord-016451-k8m2xz0e author: Chertow, Daniel S. title: Influenza, Measles, SARS, MERS, and Smallpox date: 2020-01-03 words: 6148 flesch: 36 summary: The timeline of influenza virus shedding in children and adults in a household transmission study of influenza in Managua Long-term shedding of influenza virus, parainfluenza virus, respiratory syncytial virus and nosocomial epidemiology in patients with hematological disorders Estimates of the reproduction number for seasonal, pandemic, and zoonotic influenza: a systematic review of the literature Influenza virus-induced lung injury: pathogenesis and implications for treatment The pathology of influenza virus infections Bacterial coinfection in influenza: a grand rounds review Human infection with highly pathogenic avian influenza A(H7N9) virus, China Molecular pathogenesis of H5 highly pathogenic avian influenza: the role of the haemagglutinin cleavage site motif Immunobiology of influenza vaccines Airborne transmission of measles in a physician's office Measles virus host invasion and pathogenesis Pathological consequences of systemic measles virus infection Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques The clinical significance of measles: a review The basic reproduction number (R0) of measles: a systematic review Early waning of maternal measles antibodies in era of measles elimination: longitudinal study Measles virus-induced suppression of immune responses Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality Evidence of airborne transmission of the severe acute respiratory syndrome virus Model parameters and outbreak control for SARS Epithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of rhesus macaques A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury Multiple organ infection and the pathogenesis of SARS Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. Seasonal influenza virus infection is largely limited to the respiratory tract; however, H5 and H7 HPAI viruses have a polybasic cleave site within the hemagglutinin allowing for replication outside of the respiratory tract [65, 66] . keywords: acute; coronavirus; cov; days; disease; east; infection; influenza; measles; mers; middle; patients; sars; smallpox; syndrome; transmission cache: cord-016451-k8m2xz0e.txt plain text: cord-016451-k8m2xz0e.txt item: #39 of 427 id: cord-016499-5iqpl23p author: Mackay, Ian M. title: Rhinoviruses date: 2014-02-27 words: 23417 flesch: 34 summary: ARIs linked to HRV infections are associated with excessive and perhaps inappropriate antibiotic prescribing and with significant direct and indirect healthcare expenditure. ARIs linked to HRV infections are associated with excessive and perhaps inappropriate antibiotic prescribing [ 4 ] and with signifi cant direct and indirect healthcare expenditure [ 5 , 6 ] . keywords: acute; adults; airway; antiviral; ari; asthma; cells; children; cold; culture; defi; detection; disease; exacerbations; host; hrsv; hrv; hrv infection; hrvs; human; identifi; ifn; illness; infection; infl; nasal; pcr; receptor; response; rhinovirus; rna; role; species; studies; study; symptoms; time; tract; type; viruses cache: cord-016499-5iqpl23p.txt plain text: cord-016499-5iqpl23p.txt item: #40 of 427 id: cord-016882-c9ts2g7w author: Ribeiro, Edna title: Viruses Present Indoors and Analyses Approaches date: 2017-06-12 words: 10252 flesch: 32 summary: Presently, numerous valuable cell monolayers are commercially available, and are regularly utilized in clinical laboratories for the diagnosis of virus infections. Respiratory viruses can be transported over considerable distances by air currents and be inhaled, penetrating deep into the respiratory system (Prussin II et al., 2015) . keywords: aerosol; air; cause; children; contact; contamination; disease; droplets; environments; et al; health; human; indoor; infections; influenza; patients; pcr; samples; spread; surfaces; transmission; viruses cache: cord-016882-c9ts2g7w.txt plain text: cord-016882-c9ts2g7w.txt item: #41 of 427 id: cord-016990-ot1wi3xi author: Zaki, Sherif R. title: Viral Infections of the Lung date: 2008 words: 19595 flesch: 28 summary: Preceding respiratory infection predisposing for primary and secondary invasive Haemophilus influenzae type b disease Viral-bacterial synergistic interaction in respiratory disease Immune impairment of alveolar macrophage phagocytosis during influenza virus pneumonia Mechanisms of bacterial superinfect ions in viral pneumonias Impact of respiratory virus infections on persons with chronic underlying conditions Identification of a new North American hantavirus that causes acute pulmonary insufficiency Nipah virus: a recently emergent deadly paramyxovirus Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness Varicella-related mortality in California Decline in mortality due to varicella after implementation of varicella vaccination in the United States Pneumonia caused by herpesviruses in recipients of hematopoietic cell transplants Initial genetic characterization of the 1918 Spanish influenza virus Characterization of the reconstructed 1918 Spanish influenza pandemic virus Transmission of lymphocytic choriomeningitis virus by organ transplantation A morbillivirus that caused fatal disease in horses and humans Fatal West Nile virus encephalitis in a renal transplant recipient Transmission of West Nile virus from an organ donor to four transplant recipients Transmission of rabies virus from an organ donor to four transplant recipients Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture Recovery of new agent from patients with acute respiratory illness Adenoviruses: group name proposed for new respiratory-tract viruses Adenoviruses in the immunocompromised host Fatal disseminated adenovirus infections in immunocompromised patients Respiratory disease and the adenoviruses Adenoviruses from human immunodeficiency virus-infected individuals, including two strains that represent new candidate serotypes Ad50 and Ad51 of species Bl and D, respectively Infections in 18,000 infants and children in a controlled study of respiratory tract disease. 102 Multinucleated syncytial cells similar to those seen in some SARS patients can also be found in a number of virus infections, including measles, parainfluenza viruses, RSV, and Nipah virus infections. keywords: acute; alveolar; antigens; cases; cause; cells; children; diagnosis; disease; fever; fig; giant; hsv; human; inclusions; infection; influenza; lung; measles; nipah; patients; pneumonia; pulmonary; sars; syncytial; syndrome; tissues; tract; type; varicella; virus; virus infection; viruses cache: cord-016990-ot1wi3xi.txt plain text: cord-016990-ot1wi3xi.txt item: #42 of 427 id: cord-017107-sg8n12hs author: Suri, H. S. title: Epidemiology of Acute Respiratory Failure and Mechanical Ventilation date: 2008 words: 4117 flesch: 38 summary: The burden of acute respiratory failure is high in terms of mortality and morbidity as well as the cost of its principal treatment, mechanical ventilation. Very few epidemiologic studies have evaluated the prevalence and outcome of acute respiratory failure and mechanical ventilation in general. keywords: acute; failure; hospital; lung; mortality; patients; study; ventilation cache: cord-017107-sg8n12hs.txt plain text: cord-017107-sg8n12hs.txt item: #43 of 427 id: cord-017126-7ebo3cy3 author: None title: Lungenversagen date: 2007 words: 4328 flesch: 25 summary: Die Hochfrequenzoszillation unterscheidet sich von der Hochfrequenz-Jet-Ventilation, dass sowohl neben der Inspiration auch die Exspiration aktiv ist, die Tidalvolumina kleiner sind als bei einer combined HFJV (meist unter 150 ml), der möglich anwendbare Frequenzbereich erstreckt Es kommt zunächst einerseits zu einer Erhöhung der Permeabilität der Gefäßwand mit interstitieller Ödembildung und anderseits zu einer Permeabilitätsstörung der Alveolarwand, hervorgerufen durch Membranfragmentationen der Endothelzellen und eine Degeneration der alveolären Epithelzellen (Typ-I-Pneumozyten) mit Ablösung von der Basalmembran. keywords: acute; als; alveolar; anwendung; ards; auch; bei; dass; den; der; des; die; distress; durch; eine; et al; frequency; injury; jet; kommt; lung; mit; patients; peep; respiratory; sich; sind; syndrome; und; ventilation; von; werden; wird cache: cord-017126-7ebo3cy3.txt plain text: cord-017126-7ebo3cy3.txt item: #44 of 427 id: cord-017140-k4lzwfge author: Andersen, Bjørg Marit title: Protection of Upper Respiratory Tract, Mouth and Eyes date: 2018-09-25 words: 6164 flesch: 57 summary: The market may soon be empty for respiratory protection masks during serious outbreaks such as SARS and Ebola virus. Using surgical face masks can reduce infection and also had some suppressing effect on the spread of infection by SARS [10] . keywords: air; equipment; face; hygiene; infection; influenza; mask; patient; protection; transmission; use; virus cache: cord-017140-k4lzwfge.txt plain text: cord-017140-k4lzwfge.txt item: #45 of 427 id: cord-017252-88b3preq author: Morgan, Carrie I. title: Pneumonia date: 2014-02-20 words: 6427 flesch: 26 summary: This chapter will focus on pediatric community-acquired pneumonia (CAP), immunocompromised pneumonia, and aspiration pneumonia. This chapter will focus on pediatric community-acquired pneumonia (CAP), immunocompromised pneumonia, and aspiration pneumonia. keywords: aspiration; chest; children; community; empyema; infections; infl; patients; pleural; pneumonia; pulmonary; therapy; tract cache: cord-017252-88b3preq.txt plain text: cord-017252-88b3preq.txt item: #46 of 427 id: cord-017364-d9zmdm23 author: Crowe, James E. title: Paramyxoviruses: Respiratory Syncytial Virus and Human Metapneumovirus date: 2014-02-27 words: 18355 flesch: 27 summary: A prospective, longitudinal study in young children Respiratory syncytial virus infections within families Respiratory syncytial virus infections in previously healthy working adults Antigenic and genetic diversity among the attachment proteins of group A respiratory syncytial viruses that have caused repeat infections in children Pattern of respiratory syncytial virus epidemics in Finland: two-year cycles with alternating prevalence of groups A and B Subgroup characteristics of respiratory syncytial virus strains recovered from children with two consecutive infections An antigenic analysis of respiratory syncytial virus isolates by a plaque reduction neutralization test Antigenic characterization of respiratory syncytial virus strains with monoclonal antibodies Strain-specifi c serum antibody responses in infants undergoing primary infection with respiratory syncytial virus The G glycoprotein of human respiratory syncytial viruses of subgroups A and B: extensive sequence divergence between antigenically related proteins Clinical severity of respiratory syncytial virus group A and B infection in Sydney, Australia Occurrence of groups A and B of respiratory syncytial virus over 15 years: associated epidemiologic and clinical characteristics in hospitalized and ambulatory children Severity of respiratory syncytial virus infection is related to virus strain Variation in severity of respiratory syncytial virus infections with subtype Distribution and clinical impact of human respiratory syncytial virus genotypes in hospitalized children over 2 winter seasons RSV infection-not for kids only Impact of respiratory syncytial virus infection on surgery for congenital heart disease: postoperative course and outcome Variable morbidity of respiratory syncytial virus infection in patients with underlying lung disease: a review of the PICNIC RSV database. Routine isolation procedure vs routine procedure supplemented by use of masks and goggles The use of eye-nose goggles to control nosocomial respiratory syncytial virus infection Rapid identifi cation of respiratory viruses: impact on isolation practices and transmission among immunocompromised pediatric patients Nosocomial respiratory syncytial virus infections: prevention and control in bone marrow transplant patients Respiratory syncytial virus infections in infants: quantitation and duration of shedding Quantitative shedding patterns of respiratory syncytial virus in infants Environmental and demographic risk factors for respiratory syncytial virus lower respiratory tract disease Casecontrol study of the risk factors linked to respiratory syncytial virus infection requiring hospitalization in premature infants born at a gestational age of 33-35 weeks in Spain The Pediatric Investigators Collaborative Network on Infections in Canada study of predictors of hospitalization for respiratory syncytial virus infection for infants born at 33 through 35 completed weeks of gestation Respiratory syncytial virus in infants and children Differential gender response to respiratory infections and to the protective effect of breast milk in preterm infants Risk factors for respiratory syncytial virusassociated lower respiratory illnesses in the fi rst year of life Epidemiologic patterns of acute lower respiratory disease of children in a pediatric group practice Epidemiology of acute lower respiratory disease in children Clinically useful method for the isolation of respiratory syncytial virus Bronchiolitis-associated hospitalizations among American Indian and Alaska Native children Modes of transmission of respiratory syncytial virus Possible transmission by fomites of respiratory syncytial virus Infectivity of respiratory syncytial virus by various routes of inoculation An outbreak of febrile illness and pneumonia associated with respiratory syncytial virus infection Respiratory syncytial virus load predicts disease severity in previously healthy infants Illness severity, viral shedding, and antibody responses in infants hospitalized with bronchiolitis caused by respiratory syncytial virus Latency and persistence of respiratory syncytial virus despite T cell immunity Respiratory syncytial virus infection of human mononuclear leukocytes in vitro and in vivo Respiratory syncytial virus RNA in cells from the peripheral blood during acute infection Speculation on pathogenesis in death from respiratory syncytial virus infection Demonstration of respiratory syncytial virus in an autopsy series Respiratory syncytial virus infection of human airway epithelial cells is polarized, specifi c to ciliated cells, and without obvious cytopathology Pathological changes in virus infections of the lower respiratory tract in children Age as a factor in the distribution of lower-airway conductance and in the pathologic anatomy of obstructive lung disease Seasonality of invasive pneumococcal disease: temporal relation to documented infl uenza and respiratory syncytial viral circulation Vaccine keywords: acute; adults; antibodies; cells; children; detection; disease; human; infants; infection; infl; metapneumovirus; metapneumovirus infection; mpv; patients; protein; respiratory; risk; rsv; studies; study; syncytial; tract; vaccine; viral; virus; virus infection; viruses; years cache: cord-017364-d9zmdm23.txt plain text: cord-017364-d9zmdm23.txt item: #47 of 427 id: cord-017499-51yy7y9n author: Freye, Enno title: Mechanism of Action of Opioids and Clinical Effects date: 2008 words: 24978 flesch: 42 summary: It is assumed that opioid receptors mediate Opioid receptors are found in several areas of the brain, particularly in the periaqueductal grey matter, and throughout the spinal cord ( Figure II-9 ). There, opioids act as agonists at highly definite receptor sites, and there is general agreement on the existence of at least three types of opioid receptor sites (Table II-1). keywords: action; activity; addition; affinity; agonist; analgesic; anesthesia; antagonist; binding; brain; cough; depression; dose; drug; effect; fentanyl; figure; following; heroin; increase; morphine; naloxone; nerve; nucleus; opioid; opioid receptor; opium; pain; patients; potency; potent; receptor; response; results; sites; solution; sufentanil; system; use cache: cord-017499-51yy7y9n.txt plain text: cord-017499-51yy7y9n.txt item: #48 of 427 id: cord-017715-99ri6x0y author: Zhou, Bo-Ping title: SARS date: 2015-07-25 words: 8861 flesch: 42 summary: On March 21, 2003 , Hong Kong University fi rstly separated and cultured coronavirus from the nasopharyngeal specimen of SARS patients by Vero cells, and then several laboratories of Canada and America disease center and SARS international coordination group also cultured coronavirus. According to the report of WHO, SARS epidemics was found in total 29 The main source of infection is SARS patients, and other infectious sources such as animals need to be further consolidated. keywords: changes; chest; coronavirus; density; disease; head; lesions; lung; patients; phase; pulmonary; ray; sars; shadows; syndrome cache: cord-017715-99ri6x0y.txt plain text: cord-017715-99ri6x0y.txt item: #49 of 427 id: cord-017784-4r3fpmlb author: Foccillo, Giampiero title: The Infections Causing Acute Respiratory Failure in Elderly Patients date: 2019-08-06 words: 3573 flesch: 26 summary: Severe community-acquired pneumonia and acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are causes of acute respiratory failure (ARF) in elderly patients. Elderly patients are more predisposed to pneumonia because of their impaired gag reflex, decreased mucociliary function, waning immunity, impaired febrile response, and chronic disease (diabetes mellitus, chronic obstructive pulmonary disease, chronic heart failure, cancer and chronic renal insufficiency). keywords: acute; disease; exacerbations; failure; patients; pneumonia; therapy cache: cord-017784-4r3fpmlb.txt plain text: cord-017784-4r3fpmlb.txt item: #50 of 427 id: cord-017897-mbwm0ytg author: Chiumello, Davide title: The Acute Respiratory Distress Syndrome: Diagnosis and Management date: 2018-10-01 words: 4827 flesch: 28 summary: Compressive forces and computed tomography-derived positive end-expiratory pressure in acute respiratory distress syndrome Recruitment maneuvers in acute respiratory distress syndrome and during general anesthesia Effects of alveolar recruitment maneuvers on clinical outcomes in patients with acute respiratory distress syndrome: a systematic review and meta-analysis Bedside ultrasound assessment of positive end-expiratory pressure-induced lung recruitment Lung stress and strain during mechanical ventilation: any safe threshold? Low-dose chest computed tomography for quantitative and visual anatomical analysis in patients with acute respiratory distress syndrome Stress and strain within the lung The assessment of transpulmonary pressure in mechanically ventilated ARDS patients Lung protective ventilation strategy for the acute respiratory distress syndrome Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome Driving pressure and survival in the acute respiratory distress syndrome Balancing neuromuscular blockade versus preserved muscle activity Low mortality rate in adult respiratory distress syndrome using low-volume, pressure-limited ventilation with permissive hypercapnia: a prospective study Driving pressure and intraoperative protective ventilation Neuromuscular blocking agents in patients with acute respiratory distress syndrome: a summary of the current evidence from three randomized controlled trials The prone position in ARDS patients Use of extreme position changes in acute respiratory failure Prone position in acute respiratory distress syndrome. In respiratory failure patients, lung ultrasound is characterized mainly by B-line (hyperechogenic vertical artifact line that starts from pleura) keywords: acute; ards; distress; failure; lung; patients; pressure; syndrome; ventilation cache: cord-017897-mbwm0ytg.txt plain text: cord-017897-mbwm0ytg.txt item: #51 of 427 id: cord-018302-lmly43rd author: Renaud, Christian title: Respiratory Syncytial Virus and Human Metapneumovirus Infection in Transplant Recipients date: 2016-02-15 words: 10503 flesch: 20 summary: Infectious Diseases S. Oral ribavirin therapy for respiratory syncytial virus infections in moderately to severely immunocompromised patients Oral versus inhaled ribavirin therapy for respiratory syncytial virus infection after lung transplantation Oral ribavirin for respiratory syncytial virus infection after lung transplantation: effi cacy and cost-effi ciency Respiratory Syncytial Virus and Human Metapneumovirus Infection in Transplant Recipients Immunoglobulin administration and ribavirin therapy: effi cacy in respiratory syncytial virus infection of the cotton rat Intravenous immunoglobulin treatment of respiratory syncytial virus infections in infants and young children Immunotherapy of respiratory syncytial virus pneumonia following bone marrow transplantation Respiratory syncytial virus immune globulin treatment of RSV lower respiratory tract infection in previously healthy children Respiratory syncytial virus infections in adult bone marrow transplant recipients Respiratory syncytial virus infection in recipients of allogeneic stem-cell transplantation: a retrospective study of the incidence, clinical features, and outcome A randomized, double-blind, placebo-controlled study of an RNAibased therapy directed against respiratory syncytial virus Phase I study of intravenous ribavirin treatment of respiratory syncytial virus pneumonia after marrow transplantation Prevention and treatment of respiratory syncytial virus and parainfl uenza viruses in immunocompromised patients Ribavirin therapy in bone marrow transplant recipients with viral respiratory tract infections Lassa fever. Effective therapy with ribavirin Prospective, double-blind, concurrent, placebo-controlled clinical trial of intravenous ribavirin therapy of hemorrhagic fever with renal syndrome Respiratory syncytial virus upper respiratory tract illnesses in adult blood and marrow transplant recipients: combination therapy with aerosolized ribavirin and intravenous immunoglobulin Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by ribavirin and immune serum globulin in vitro Effect of ribavirin and glucocorticoid treatment in a mouse model of human metapneumovirus infection Infection control of nosocomial respiratory viral disease in the immunocompromised host Seasonal infl uenza in adults and children-diagnosis, treatment, chemoprophylaxis, and institutional outbreak management: clinical practice guidelines of the Infectious Diseases Society of America Infectious Disease Society of A, American Society of B and Marrow T. Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients Updated guidance for palivizumab prophylaxis among infants and young children at increased risk of hospitalization for respiratory syncytial virus infection Immune-globulin prophylaxis of respiratory syncytial virus infection in patients undergoing stem-cell transplantation Phase 1 evaluation of the respiratory syncytial virus-specifi c monoclonal antibody palivizumab in recipients of hematopoietic stem cell transplants A broadly neutralizing human monoclonal antibody exhibits in vivo effi cacy against both human metapneumovirus and respiratory syncytial virus Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective Oral GS-5806 activity in a respiratory syncytial virus challenge study Chemotherapy of respiratory syncytial virus infections: the fi nal breakthrough Preventing severe respiratory syncytial virus disease: passive, active immunisation and new antivirals Structural basis of respiratory syncytial virus neutralization by motavizumab The changing landscape of respiratory syncytial virus Live-attenuated respiratory syncytial virus vaccines Chimpanzee adenovirus-and MVA-vectored respiratory syncytial virus vaccine is safe and immunogenic in adults Phase 1 study of the safety and immunogenicity of a live, attenuated respiratory syncytial virus and parainfl uenza virus type 3 vaccine in seronegative children Attenuated human parainfl uenza virus type 1 (HPIV1) expressing the fusion glycoprotein of human respiratory syncytial virus (RSV) as a bivalent HPIV1/RSV vaccine New approaches for immunization and therapy against human metapneumovirus keywords: cell; disease; hmpv; hsct; human; infection; patients; pneumonia; recipients; ribavirin; rsv; study; therapy; tract; transplant; transplant recipients; virus; viruses cache: cord-018302-lmly43rd.txt plain text: cord-018302-lmly43rd.txt item: #52 of 427 id: cord-018319-tylkbh4h author: Chemaly, Roy F. title: Respiratory Viruses date: 2011-01-04 words: 8856 flesch: 33 summary: Community respiratory virus infections in immunocompromised patients with cancer Common community respiratory viruses in patients with cancer: more than just common colds Harrison's principles of internal medicine Circulation patterns of genetically distinct group A and B strains of human respiratory syncytial virus in a community Respiratory syncytial virus and parainfluenza virus Risk of primary infection and reinfection with respiratory syncytial virus Respiratory syncytial virus infections in previously healthy working adults Respiratory syncytial and other virus infections in persons with chronic cardiopulmonary disease Can respiratory syncytial virus and influenza A be distinguished clinically in institutionalized older persons? Symptomatic respiratory syncytial virus infection in previously healthy young adults living in a crowded military environment Respiratory syncytial virus and parainfluenza virus infections in the immunocompromised host Respiratory virus infections in immunocompetent and immunocompromised persons Respiratory syncytial virus infection in adults Respiratory syncytial virusinduced acute lung injury in adult patients with bone marrow transplants Combination therapy with aerosolized ribavirin and intravenous immunoglobulin for respiratory syncytial virus disease in adult bone marrow transplant recipients Diagnosis and epidemiology of community-acquired respiratory virus infections in the immunocompromised host Respiratory virus infections after stem cell transplantation: a prospective study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation Viral pneumonia in the immunocompromised adult with neoplastic disease: the role of common community respiratory viruses Community respiratory virus infections among hospitalized adult bone marrow transplant recipients Characteristics and outcome of respiratory syncytial virus infection in patients with leukemia Community respiratory virus infections in immunocompromised patients: hematopoietic stem cell and solid organ transplant recipients and individuals with human immunodeficiency virus infection Respiratory syncytial virus infections in pediatric liver transplant recipients Viral and host factors in human respiratory syncytial virus pathogenesis Community-based respiratory viral infections in HIV-positive patients with lower respiratory tract disease: a prospective bronchoscopic study Rapid diagnosis of respiratory syncytial virus infections in immunocompromised adults Rapid simultaneous diagnosis of infections with respiratory syncytial viruses A and B, influenza viruses A and B, and human parainfluenza virus types 1, 2, and 3 by multiplex quantitative reverse transcription-polymerase chain reaction-enzyme hybridization assay ( In this chapter, we discuss the common clinical presentations, diagnostic methods, treatments, and prevention measures for respiratory virus infections in general and in cancer patients in particular (Table 32. keywords: adenovirus; cause; cell; children; hsct; infections; influenza; patients; pneumonia; recipients; rsv; transplant; transplantation; virus; viruses cache: cord-018319-tylkbh4h.txt plain text: cord-018319-tylkbh4h.txt item: #53 of 427 id: cord-018408-ttae193b author: Haddad, Imad Y. title: Pneumonia and Empyema date: 2008-11-15 words: 6161 flesch: 29 summary: National Nosocomial Infections Surveillance System Prevalence of nosocomial infections in pediatric intensive care unit patients at US Children's Hospitals Fourth Decennial International Conference on Nosocomial and Healthcare-Associated Infections Clinical diagnosis of ventilator associated pneumonia revisited: comparative validation using immediate post-mortem lung biopsies Diagnosis of nosocomial bacterial pneumonia in acute, diffuse lung injury Management of bacterial pneumonia in ventilated patients. Finally, aspiration pneumonia caused by chronic inoculation of the lower respiratory tract with large amounts of less virulent bacteria in a susceptible host prone to aspiration is also observed in the PICU. keywords: aspiration; bacterial; children; diagnosis; disease; empyema; host; infections; infl; lung; patients; pleural; pneumonia cache: cord-018408-ttae193b.txt plain text: cord-018408-ttae193b.txt item: #54 of 427 id: cord-018421-wy3mtafh author: Waghmare, Alpana title: Rhinovirus, Coronavirus, Enterovirus, and Bocavirus After Hematopoietic Cell Transplantation or Solid Organ Transplantation date: 2016-02-15 words: 5436 flesch: 22 summary: HRV viral RNA was detected in the sera of 30 (12%) of 243 pediatric patients with severe HRV respiratory infection, with HRV-C being the predominant species [ 31 ] . Respiratory virus infections after stem cell transplantation: a prospective study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation Respiratory virus infections after marrow transplant: the Fred Hutchinson cancer research center experience Respiratory viral infections after bone marrow/peripheral stem-cell transplantation: the Christie hospital experience Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients Clinical impact of community-acquired respiratory viruses on bronchiolitis obliterans after lung transplant Upper and lower respiratory tract viral infections and acute graft rejection in lung transplant recipients keywords: clinical; cov; enterovirus; hrv; human; infection; lung; patients; recipients; tract; transplant; viruses cache: cord-018421-wy3mtafh.txt plain text: cord-018421-wy3mtafh.txt item: #55 of 427 id: cord-019051-gtruu1op author: Weber, Olaf title: The role of viruses in the etiology and pathogenesis of common cold date: 2009-11-10 words: 12336 flesch: 41 summary: Indeed, approximately 80% of asthma exacerbations in children [26] and about 70% in adults [27] are associated with respiratory virus infections, and the vast majority of these are RV infections [28] . The epidemiology of acute respiratory tract infection in young children Risk of respiratory syncytial virus infection for infants from low-income families in relationship to age, sex, ethnic group and maternal antibody level Respiratory syncytial virus Differential production of inflammatory cytokines in primary infection with human metapneumovirus and with other common respiratory viruses of infancy Effectiveness of drug therapies to treat or prevent respiratory syncytial virus infection-related morbidity Genetic susceptibility to RSV disease Bronchoalveolar lavage cytokine profiles in acute asthma and acute bronchiolitis Human infant respiratory syncytial virus (RSV)-specific type 1 and 2 cytokine responses ex vivo during primary RSV infection Type 1 and type 2 cytokine imbalance in acute respiratory syncytial virus bronchiolitis Priming immunization determines T helper cytokine mRNA expression patterns in lungs of mice challenged with respiratory syncytial virus Respiratory syncytial virus deficient in soluble G protein induced an increased proinflammatory response in human lung epithelial cells The cysteinerich region of respiratory syncytial virus attachment protein inhibits innate immunity elicited by the virus and endotoxin Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus Severe respiratory syncytial virus disease in Alaska native children Palivizumab in the prophylaxis of respiratory syncytial virus infection Respiratory syncytial virus disease mechanisms implicated by human, animal model, and In vitro data facilitate vaccine strategies and new therapeutics Experimental respiratory syncytial virus infection of four species of primates Respiratory syncytial virus infects the bonnet monkey, Macaca radiata The pathogenesis of respiratory syncytial virus infection in cotton rats Enhancement of respiratory syncytial virus pulmonary pathology in cotton rats by prior intramuscular inoculation of formalin-inactivated virus Mechanism of antibody-mediated viral clearance in immunotherapy of respiratory syncytial virus infection of cotton rats Primary respiratory syncytial virus infection in mice Respiratory syncytial virus infection in mice Intracellular IFN-gamma expression in natural killer cells precedes lung CD8 + T cell recruitment during respiratory syncytial virus infection Immune-mediated disease pathogenesis in respiratory syncytial virus infection Chinchilla and murine models of upper respiratory tract infections with respiratory syncytial virus Evaluation of severe disease induced by aerosol inoculation of calves with bovine respiratory syncytial virus Complete sequence of the RNA genome of pneumonia virus of mice (PVM) Parainfluenza viruses Parainfluenza viruses Myxoviruses: Parainfluenza International Committee on Taxonomy of Viruses The role of viral glycoproteins in adsorption, penetration, and pathogenicity of viruses New frontiers opened by the exploration of host cell receptors Acquisition of serum antibodies to specific glycoproteins of parainfluenza virus 3 in children ) secretory immunological response in infants and children to parainfluenza virus types 1 and 2 Brief report: Parainfluenza virus type 3 infections: keywords: adenovirus; cause; cell; children; cold; coronavirus; disease; human; infection; influenza; pathogenesis; protein; response; rna; role; rsv; symptoms; tract; virus; viruses cache: cord-019051-gtruu1op.txt plain text: cord-019051-gtruu1op.txt item: #56 of 427 id: cord-019100-rce6kyu4 author: Heymann, Peter W. title: VIRUS-INDUCED WHEEZING IN CHILDREN: Respiratory Syncytial Virus (RSV) and Rhinovirus date: 1998-02-01 words: 4836 flesch: 26 summary: The effects of rhinovirus infections on allergic airway responses Rhinovirus produces non-specific activation of lymphocytes through a monocyte-dependent mechanism Natural history of sensitization in atopic dermatitis Rhinovirus infection of the normal human airway Computed tomographic study of the common cold Influence of maternal allergic disease during pregnancy on IgE, Alternaria skin tests and asthma in children Exacerbations of asthma in adults during experimental rhinovirus infection The etiologic and epidemiologic spectrum of bronchiolitis in pediatric practice Allergy: Early childhood asthma: The interaction between rhinovirus infections and allergic inflammation becomes significantly associated with wheezing after the age of 2 years. keywords: asthma; children; ige; infections; nasal; rhinovirus; rsv; studies; symptoms; tract; wheezing cache: cord-019100-rce6kyu4.txt plain text: cord-019100-rce6kyu4.txt item: #57 of 427 id: cord-020267-0axms5fp author: None title: RIBAVIRIN AND RESPIRATORY SYNCYTIAL VIRUS date: 1986-02-15 words: 1846 flesch: 33 summary: Effective therapy with ribavirin Mechanisms of action of ribavirin Report to the Medical Council Subcommittee on respiratory syncytial virus vaccines Respiratory syncytial virus infection: admissions to hospital in industrial, urban, and rural areas Pneumonia: an eleven-year study in a pediatric practice Respiratory syncytial viral infection in infants with congenital heart disease Respiratory syncytial virus in immunocompromised children Communicable Disease Surveillance Centre. Respiratory syncytial virus infection in the elderly 1976-82 keywords: disease; infants; patients; ribavirin; rsv cache: cord-020267-0axms5fp.txt plain text: cord-020267-0axms5fp.txt item: #58 of 427 id: cord-020700-iko8gy1e author: Calvo, Cristina title: Respiratory viral infections in a cohort of children during the first year of life and their role in the development of wheezing() date: 2017-07-06 words: 3948 flesch: 46 summary: key: cord-020700-iko8gy1e authors: Calvo, Cristina; Aguado, Isabel; García-García, María Luz; Ruiz-Chercoles, Esther; Díaz-Martinez, Eloisa; Albañil, Rosa María; Campelo, Olga; Olivas, Antonio; Muñóz-Gonzalez, Luisa; Pozo, Francisco; Fernandez-Arroyo, Rosa; Fernandez-Rincón, Adelaida; Calderon, Ana; Casas, Inmaculada title: Respiratory viral infections in a cohort of children during the first year of life and their role in the development of wheezing() date: 2017-07-06 journal: An Pediatr (Engl Ed) DOI: 10.1016/j.anpede.2016.08.008 sha: doc_id: 20700 cord_uid: iko8gy1e INTRODUCTION: It is known that infants with viral respiratory infections severe enough to require hospital admission have a high risk of developing recurrent wheezing. keywords: asymptomatic; infants; infections; life; risk; viral; wheezing cache: cord-020700-iko8gy1e.txt plain text: cord-020700-iko8gy1e.txt item: #59 of 427 id: cord-021277-smw6owql author: None title: Respiratory distress syndrome: recent research date: 2013-02-17 words: 117 flesch: -1 summary: 21277 cord_uid: smw6owql nan In infants Effects In adults Use of corticosteroids in the adult respiratory distress syndrome -a clinical review Adult respiratory distress syndrome associated with parainfluenza virus type I in children Effects of prostaglandin EI on oxygen delivery and consumption in patients with the adult respiratory distress syndrome Prophylactic treatment with an aerosolized corticosteroid liposome in a porcine model of early ARDS induced by endotoxaemia Physiologic effects and side effects of prostaglandin E I in the adult respiratory distress syndrome respiratory distress and acute renal failure due to synergic bleomycin-cisplatin toxicity key: cord-021277-smw6owql authors: nan title: Respiratory distress syndrome: recent research date: 2013-02-17 journal: nan DOI: 10.2165/00128413-199107860-00060 sha: doc_id: keywords: distress cache: cord-021277-smw6owql.txt plain text: cord-021277-smw6owql.txt item: #60 of 427 id: cord-021894-lq8yr710 author: Cunningham, Steve title: Bronchiolitis date: 2018-03-13 words: 6539 flesch: 31 summary: 119 Recurrent wheeze in the year following Oxygen saturation targets in infants with bronchiolitis (BIDS): a double-blind, randomised, equivalence trial SABRE: a multicentre randomised control trial of nebulised hypertonic saline in infants hospitalised with acute bronchiolitis Nebulized hypertonic saline for bronchiolitis in the emergency department: a randomized clinical trial 7% Hypertonic saline in acute bronchiolitis: a randomized controlled trial 3% hypertonic saline versus normal saline in inpatient bronchiolitis: a randomized controlled trial The effect of 3% and 6% hypertonic saline in viral bronchiolitis: a randomised controlled trial Nebulized hypertonic saline for bronchiolitis: a randomized clinical trial Risk factors for bronchiolitis, recurrent wheezing, and related hospitalization in preterm infants during the first year of life Chronic diseases, chromosomal abnormalities, and congenital malformations as risk factors for respiratory syncytial virus hospitalization: a population-based cohort study Bronchiolitis: diagnosis and management in children Prospective study of healthcare utilisation and respiratory morbidity due to RSV infection in prematurely born infants Trends in respiratory syncytial virus and bronchiolitis hospitalization rates in high-risk infants in a United States Nationally Representative Database Respiratory syncytial virus hospitalization trends in infants with chronic lung disease of infancy Viral etiologies of infant bronchiolitis, croup and upper respiratory illness during 4 consecutive years Viral etiology of bronchiolitis among pediatric inpatients in northern Taiwan with emphasis on newly identified respiratory viruses Occurrence of groups A and B of respiratory syncytial virus over 15 years: associated epidemiologic and clinical characteristics in hospitalized and ambulatory children Severity of respiratory syncytial virus infection is related to virus strain Immunity to and frequency of reinfection with respiratory syncytial virus Association of rhinovirus infection with increased disease severity in acute bronchiolitis Community-acquired pneumonia requiring hospitalization among U.S. adults Aetiology of childhood pneumonia in a well vaccinated South African birth cohort: a nested casecontrol study of the Drakenstein Child Health Study Respiratory syncytial virus (RSV) and its propensity for causing bronchiolitis Pecularities of lesions in viral and mycoplasma infections of the respiratory tract Recovery of the ciliated epithelium following acute bronchiolitis in infancy Respiratory syncytial virus infections in infants: quantitation and duration of shedding Respiratory syncytial virus genomic load and disease severity among children hospitalized with bronchiolitis: multicenter cohort studies in the United States and Finland Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children Type 1 and type 2 cytokine imbalance in acute respiratory syncytial virus bronchiolitis Viral specific factors contribute to clinical respiratory syncytial virus disease severity differences in infants Respiratory syncytial virus disease is mediated by age-variable IL-33 Surfactant protein A2 polymorphisms and disease severity in a respiratory syncytial virus-infected population Latitudinal variations in seasonal activity of influenza and respiratory syncytial virus (RSV): a global comparative review Altitude and environmental climate effects on bronchiolitis severity among children presenting to the emergency department Environmental drivers of the spatiotemporal dynamics of respiratory syncytial virus in the United States Viral bronchiolitis in children Epidemiology of respiratory syncytial virus bronchiolitis in hospitalized infants in Greece Duration of illness in ambulatory children diagnosed with bronchiolitis Duration of illness in infants with bronchiolitis evaluated in the emergency department The clinical burden of respiratory syncytial virus (RSV) bronchiolitis among infants in the United Kingdom (UK) Wheezing in infants: the response to epinephrine Measuring clinical severity in infants with bronchiolitis Bacteremia in children hospitalized with respiratory syncytial virus infection WHO consultation on Respiratory Syncytial Virus Vaccine Development Report from a World Health Organization Meeting held on 23-24 Effect of oxygen desaturations on subsequent medical visits in infants discharged from the emergency department with bronchiolitis Effect of oximetry on hospitalization in bronchiolitis: a randomized clinical trial Variation in inpatient diagnostic testing and management of bronchiolitis Predictors of airspace disease on chest x-ray in emergency department patients with clinical bronchiolitis: a systematic review and meta-analysis Assessing the utility of urine testing in febrile infants aged 2 to 12 months with bronchiolitis Respiratory syncytial virus (RSV) immune globulin intravenous therapy for RSV lower respiratory tract infection in infants and young children at high risk for severe RSV infections: respiratory syncytial virus immune globulin study group Reduction of respiratory syncytial virus hospitalization among premature infants and infants with bronchopulmonary dysplasia using respiratory syncytial virus immune globulin prophylaxis Palivizumab, a humanized respiratory syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants Lower respiratory tract infection caused by respiratory syncytial virus: current management and new therapeutics Epinephrine and dexamethasone in children with bronchiolitis Decreased lung function precedes severe respiratory syncytial virus infection and post-respiratory syncytial virus wheeze in term infants Clinical prediction rule for RSV bronchiolitis in healthy newborns: prognostic birth cohort study Study of montelukast for the treatment of respiratory symptoms of post-respiratory syncytial virus bronchiolitis in children Randomised placebo controlled trial of nebulised corticosteroids in acute respiratory syncytial viral bronchiolitis on behalf of the RSVCSG. keywords: acute; bronchiolitis; care; children; diagnosis; disease; infants; infection; risk; rsv; tract; virus cache: cord-021894-lq8yr710.txt plain text: cord-021894-lq8yr710.txt item: #61 of 427 id: cord-022082-1dq623oe author: Greaves, Peter title: Respiratory Tract date: 2007-09-28 words: 19712 flesch: 22 summary: ^^^ Plasticembedded sections also show the inclusions in other pulmonary cells including pneumocytes attached to the alveolar walls, from which they can be seen discharging into the alveolar spaces. In contrast to findings in people, squamous cell lung tumours are only occasionally seen arising spontaneously in laboratory animals. keywords: administration; agents; airways; alveolar; animals; bronchial; cells; changes; drug; effects; epithelium; fibrosis; humans; hyperplasia; inhalation; laboratory; laboratory animals; lesions; lung; macrophages; mice; mucosa; nasal; olfactory; pulmonary; rats; respiratory; species; studies; study; tissue; toxicity; tract; type cache: cord-022082-1dq623oe.txt plain text: cord-022082-1dq623oe.txt item: #62 of 427 id: cord-022084-hap7flng author: ARRUDA, EURICO title: Respiratory Tract Viral Infections date: 2009-05-15 words: 19198 flesch: 38 summary: Although a HMPV vaccine is not available at this time, the demonstration that hamsters, ferrets, and African green monkeys are susceptible to infection by HMPV, and that hamsters vaccinated with serotype A The epidemiology of acute respiratory tract infection in young children: Comparison of findings from several developing countries Report of a workshop on respiratory viral infections: Epidemiology, diagnosis, treatment and prevention Acute respiratory viral infections in ambulatory children of urban northeast Brazil Longitudinal studies of infectious diseases and physical growth of infants in Huascar, an underprivileged peri-urban community in At the edge of Development: Health Crises in a Transitional Society Epidemiology of acute respiratory infections in children of developing countries Pan American Health Organization: Acute respiratory infections in the Americas The magnitude of mortality from acute respiratory infections in children under 5 years in developing countries Acute lower respiratory tract infections in hospitalized patients with diarrhea in Dhaka Day-care center attendance and hospitalization for lower respiratory tract illness Viral respiratory infections in young children attending day care in urban Northeast Brazil Epidemiology and seasonality of respiratory tract virus infections in the tropics The cultural context of breastfeeding: Perspectives on the recent decline in breast-feeding in Northeast and Northcentral Brazil Reduced mortality among children in Southern India receiving a small weekly dose of vitamin A Search for a solution: Blending oral rehydration therapy (ORT) and popular medicine Pathogenesis of respiratory infections due to influenza virus: Implications for developing countries Respiratory viruses predisposing to bacterial infections: Role of neuraminidase Influenza: Emergence and control Orthomyxoviridae: The viruses and their replication Influenza virus Viral vaccines for the prevention of childhood pneumonia in developing nations: Priorities and prospects The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics in children Etiology of acute respiratory infections in children in tropical southern India A community-based study of acute respiratory tract infection in Thai children Etiology of acute lower respiratory tract infection in children from Alabang, Metro Manilla Outbreak of influenza type A (H1N1) in Iporanga Antigenic and genomic relation between human influenza viruses that circulated in Argentina in the period 1995-1999 and the corresponding vaccine components Regional perspectives on influenza surveillance in Africa H5N1 influenza: A protean pandemic threat Influenza type A and B infections in hospitalized pediatric patients Influenza viruses, cell enzymes, and pathogenicity Detection of influenza virus by centrifugal inoculation of MDCK cells and staining with monoclonal antibodies Rapid detection and simultaneous subtype differentiation of influenza A viruses by real time PCR Rapid and sensitive method using multiplex real-time PCR for diagnosis of infections by influenza A and influenza B viruses, respiratory syncytial virus, and parainfluenza viruses 1, 2, 3, and 4 Rational design of potent sialidase-based inhibitors of influenza virus replication Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenzavirus infections Resistant influenza 31 Up to 50% of influenza virus infections in adults are subclinical. keywords: acute; adults; age; cause; cell; children; clinical; cov; days; detection; disease; hcov; hmpv; hrv; human; illness; infants; infections; influenza; patients; pcr; rna; rsv; sars; studies; tract; tropical; vaccine; virus; viruses; years cache: cord-022084-hap7flng.txt plain text: cord-022084-hap7flng.txt item: #63 of 427 id: cord-022337-f3a349cb author: Busse, William W. title: Infections date: 2007-05-09 words: 7609 flesch: 35 summary: Over 2 years, there were 102 confirmed viral respiratory infections and 139 episodes of wheezing; 58 episodes (42%) of wheezing occurred in relationship to viral respiratory infections, of which RSV was the most prevalent and likely to provoke asthma. In these children, the presence of allergy, i.e. positive radioallergosorbant test (RAST) values, and not passive cigarette smoke exposure, was the dominant risk factor for wheezing with viral respiratory infections. keywords: age; airway; asthma; children; function; infections; relationship; response; rhinovirus; viruses; wheezing; years cache: cord-022337-f3a349cb.txt plain text: cord-022337-f3a349cb.txt item: #64 of 427 id: cord-022431-f6caajxy author: WELLEMANS, G. title: Bovine Respiratory Syncytial Virus date: 2013-11-17 words: 4859 flesch: 47 summary: Studies on an outbreak in Japan Structure of bovine respiratory syncytial virus Experimental infection of calves with respiratory syncytial virus Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine Demonstration that glycoprotein G is the attachment protein of respiratory syncytial virus Interferon in nasal secretions from infants with viral respiratory tract infections Immunopathologic mechanisms in lower respiratory tract disease of infants due to respiratory syncytial virus Experimental respiratory syncytial virus pneumonia in young calves: microbiologic and immunofluorescent findings Serological evidence for the intervention of bovine respiratory syncytial virus in a respiratory disease outbreak in moroccan cattle Bovine respiratory syncytial virus: host range in laboratory animals and cell cultures Bovine respiratory viruses Experimentally induced respiratory syncytial viral infection in calves Effect of vaccinal serum antibodies on bovine respiratory syncytial viral infection in calves Two distinct subtypes of human respiratory syncytial virus Preparation and characterization of monoclonal antibodies directed against five structural components of human respiratory syncytial virus subgroup B A respiratory syncytial virus of bovine origin Use of indirect fluorescent antibody test in the detection of bovine respiratory syncytial virus antibodies in bovine serum Mechanisms of immunity to respiratory syncytial virus in cotton rats Isolation of respiratory syncytial virus from calves with acute respiratory disease Susceptibility of bovine macrophage and tracheal-ring cultures to bovine viruses Bovine respiratory syncytial virus infection of bovine embryonic lung cultures: a kinetic study by the fluorescent antibody technique Isolation, characterization and pathogenicity studies of a bovine respiratory syncytial virus Respiratory syncytial virus from cattle with a respiratory disease A comparison of three vaccines against respiratory syncytial virus in calves Diagnosis of bovine respiratory syncytial virus infection by complement fixation test Respiratory syncytial virus infection in mice Diagnosis of respiratory syncytial virus infection in the bovine respiratory tract by immunofluorescence Isolation of respiratory syncytial virus from cattle with a respiratory disease Mechanisms of infection in the respiratory tract Serological evidence of respiratory syncytial virus infection in sheep Infectious bovine rhinotracheitis virus infection in bulls, with special reference to preputial infection Respiratory syncytial virus pneumonia in young calves: clinical and pathologic findings A comparison of the polypeptides of human and bovine respiratory syncytial viruses and murine pneumonia virus Specific immune tolerance in an apparently healthy bull persistently infected with bovine viral diarrhea virus Respiratory syncytial virus diagnosis Experimental infection of calves with bovine respiratory syncytial virus (Quebec strain) Interferon, fluorescent antibody and neutralizing antibody responses in sera of calves inoculated with bovine respiratory syncytial virus Hemagglutination passive: application de la méthode au diagnostic sérologique des affections respiratoires virales des jeunes bovins Cell-mediated immune response in cattle to bovine respiratory syncytial virus Speculation on pathogenesis in death from respiratory syncytial virus infection Interferon production in children with respiratory syncytial, influenza and parainfluenza virus infections Bronchopneumonia of Yearling Cattle Prevention of pinkengriep by vaccination, a field trial The etiological role of bovine respiratory syncytial virus in pinkengriep Detection of respiratory syncytial virus in nasopharyngeal secretions by inhibition of enzyme-linked immunosorbent assay Respiratory syncytial virus mRNA coding assignments Nomi virus, a virus isolated from an apparently new epizootic respiratory disease of cattle Bovine respiratory syncytial virus. keywords: antibodies; bovine; brsv; calves; et al; infection; syncytial; virus cache: cord-022431-f6caajxy.txt plain text: cord-022431-f6caajxy.txt item: #65 of 427 id: cord-023509-tvqpv6fp author: Corrin, Bryan title: Occupational, environmental and iatrogenic lung disease date: 2011-03-02 words: 42595 flesch: 39 summary: Aluminium powder holds a paradoxical position in regard to lung disease. 366 More directly, welders may be exposed to asbestos insulation that they themselves use, while welders of special steel alloys run the risk of metal-induced asthma, metal fume fever, polymer fume fever and the consequences of toxic metal fume inhalation, 367 all of which are described separately in this chapter, as is lung disease in aluminium welders. keywords: acute; air; aluminium; alveolar; analysis; asbestos; asbestos exposure; asbestos fibres; asthma; beryllium; blood; bodies; bronchiolitis; cases; cause; cells; changes; chronic; coal; damage; diffuse; drug; dust; dust exposure; dust pneumoconiosis; effects; electron; emphysema; evidence; exposure; factor; fibres; fibrosis; fig; gas; interstitial; lesions; lung; lung cancer; lung disease; lung injury; lung tissue; macrophages; mineral; non; occupational; oedema; oxygen; particles; patients; pneumoconiosis; pneumonia; pulmonary; risk; silica; silicosis; smoking; study; syndrome; tissue; toxicity; type; water; workers cache: cord-023509-tvqpv6fp.txt plain text: cord-023509-tvqpv6fp.txt item: #66 of 427 id: cord-023528-z9rc0ubj author: Wilkins, Pamela A. title: Disorders of Foals date: 2009-05-18 words: 42606 flesch: 40 summary: A syndrome of bronchointerstitial pneumonia and acute respiratory distress has been described in older foals and appears to be a distinct entity from acute respiratory distress syndrome in neonatal foals in association with sepsis. One can use these measurements and the ultrasonographic appearance of the internal umbilical structures from clinically normal foals as references to diagnose abnormalities of the umbilical structures in neonatal foals. keywords: abnormalities; acute; administration; age; author; birth; blood; care; cases; cell; concentration; days; deformities; diagnosis; diarrhea; disease; effects; equine; failure; fetal; fetus; fluid; foals; function; gastric; horses; hours; human; hypoxia; infants; infection; injury; intravenous; joint; limb; mares; neonatal; neonate; newborn; oxygen; patients; pneumonia; rate; renal; result; risk; sepsis; signs; specific; therapy; treatment; use; ventilation cache: cord-023528-z9rc0ubj.txt plain text: cord-023528-z9rc0ubj.txt item: #67 of 427 id: cord-023711-xz5ftnat author: MORENO-LÓPEZ, J. title: Acute Respiratory Disease in Cattle date: 2013-11-17 words: 1526 flesch: 45 summary: The symptomatology of acute respiratory disease is similar in different outbreaks and includes depression, inappétence, dullness, increased respiration and pulse rates in the early stages. As diagnostic techniques become more widely applied, an increasing number of viruses has been isolated from cattle with acute respiratory disease. keywords: cattle; disease; virus; viruses cache: cord-023711-xz5ftnat.txt plain text: cord-023711-xz5ftnat.txt item: #68 of 427 id: cord-023712-nptuuixw author: Bower, John title: Bronchiolitis date: 2014-10-31 words: 5408 flesch: 34 summary: The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis Bronchiolitis: clinical characteristics associated with hospitalization and length of stay Bronchiolitisassociated mortality and estimates of respiratory syncytial virus-associated deaths among US children, 1979-1997 Selected populations at increased risk from respiratory syncytial virus infection Respiratory syncytial virus Bronchiolitis in US emergency departments, 1992 to 2000: epidemiology and practice variation Environmental and demographic risk factors for respiratory syncytial virus lower respiratory tract disease The burden of respiratory syncytial virus infection among healthy children Risk factors in children hospitalized with RSV bronchiolitis versus non-RSV bronchiolitis Innate immune dysfunction is associated with enhanced disease severity in infants with severe respiratory syncytial virus bronchiolitis Lower respiratory tract infections among American Indian and Alaska Native children and the general population of U.S. children Effect of oxygen supplementation on length of stay for infants hospitalized with acute viral bronchiolitis Prospective multicenter study of bronchiolitis: predicting safe discharges from the emergency department Predicting deterioration in previously healthy infants hospitalized with respiratory syncytial virus infection Duration of illness in ambulatory children diagnosed with bronchiolitis Respiratory syncytial virus-related apnea in infants: demographics and outcome Risk factors for respiratory syncytial virus associated apnoea Identifying hospitalized infants who have bronchiolitis and are at high risk for apnea Benefits of thickened feeds in previously healthy infants with respiratory syncytial virus bronchiolitis Aspiration: a factor in rapidly deteriorating bronchiolitis in previously healthy infants? Risks for bacteremia and urinary tract infections in young febrile children with bronchiolitis Risk of serious bacterial infection in young febrile infants with respiratory syncytial virus infections A prospective study of the risk for serious bacterial infections in hospitalized febrile infants with or without bronchiolitis Office-based treatment and outcomes for febrile infants with clinically diagnosed bronchiolitis Causal links between RSV infection and asthma: no clear answers to an old question Respiratory syncytial virus bronchiolitis and the pathogenesis of childhood asthma Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years Diagnostic assays for respiratory syncytial virus disease Comparison of fast-track diagnostics respiratory pathogens multiplex real-time RT-PCR assay with in-house singleplex assays for comprehensive detection of human respiratory viruses When an infant wheezes: clues to the differential The treatment of bronchiolitis International variation in the management of infants hospitalized with respiratory syncytial virus Bronchodilators for bronchiolitis Agency for Healthcare Research and Quality. Agency for Healthcare Research and Quality Systemic corticosteroids in infant bronchiolitis: a meta-analysis Glucocorticoids for acute viral bronchiolitis in infants and young children A multicenter, randomized, controlled trial of dexamethasone for bronchiolitis Nebulized hypertonic saline solution for acute bronchiolitis in infants Use of continuous positive airway pressure (CPAP) in acute viral bronchiolitis: a systematic review Randomised controlled trial of nasal continuous positive airways pressure (CPAP) in bronchiolitis Nasal continuous positive airway pressure with heliox versus air oxygen in infants with acute bronchiolitis: a crossover study High flow nasal cannulae therapy in infants with bronchiolitis Humidified high-flow nasal cannula: is it the new and improved CPAP? keywords: age; bronchiolitis; children; disease; infants; infection; risk; rsv; syncytial; virus cache: cord-023712-nptuuixw.txt plain text: cord-023712-nptuuixw.txt item: #69 of 427 id: cord-023721-e0zp2gux author: Meissner, H. Cody title: Bronchiolitis date: 2013-02-10 words: 5112 flesch: 27 summary: Reassessment of the indications for ribavirin therapy in respiratory syncytial virus infections Aerosolized ribavirin treatment of infants with respiratory syncytial viral infection: a randomized doubleblind study Ribavirin aerosol treatment of bronchiolitis associated with respiratory syncytial virus infection in infants Prevention and control of influenza with vaccines Neuraminidase inhibitors for treatment of influenza A and B infections Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza infection: randomized controlled trials for prevention and treatment Clinical efficacy and safety of the orally inhaled neuraminidase inhibitor zanamivir in the treatment of influenza: a randomized, doubleblind, placebocontrolled European study Zanamivir for treatment of symptomatic influenza A and B infection in children five to twelve years of age: a randomized controlled trial Intravenous immunoglobulin treatment of respiratory syncytial virus infections in infants and young children Controlled trial to evaluate protection of high risk infants against RSV by using standard intravenous immune globulin Respiratory syncytial virus (RSV) immunoglobulin therapy for RSV lower respiratory tract infection in infants and young children at high risk for severe RSV infection Respiratory syncytial virus immune globulin treatment of RSV lower respiratory tract infection in previously healthy children Reduction of respiratory syncytial virus (RSV) in tracheal aspirates in intubated infants by the use of humanized monoclonal antibody to RSV F protein A randomized controlled trial of vitamin A in children with severe measles Serum vitamin A levels in respiratory syncytial virus infection Vitamin A and respiratory syncytial virus infection The relationship of childhood respiratory illness to adult obstructive airway disease Pulmonary function changes in children after respiratory syncytial virus infection in infancy The relationship of RSVspecific immunoglobulin E antibody responses in infancy, recurrent wheezing, and pulmonary function at age 7-8 years Asthma and wheezing in the first six years of life Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years Evaluation of combined live, attenuated RSV and parainfluenza 3 virus vaccines in infants and young children 38 Diagnosis and management of bronchiolitis The burden of RSV infection in young children Bronchiolitis associated hospitalizations among US children, 1980-1966 The epidemiology of acute respiratory tract infection in young children: comparison of findings from developing countries Epidemiologic patterns of acute lower respiratory disease of children in a pediatric group practice A newly discovered human pneumovirus isolated from young children with respiratory tract disease Incidence and etiology of pneumonia, croup and bronchiolitis in preschool children belonging to a prepaid medical care group over a fouryear period Epidemiology of respiratory syncytial virus infection in Washington, DC. keywords: bronchiolitis; children; disease; hospitalization; infants; infection; risk; rsv; season; syncytial; tract; virus; viruses cache: cord-023721-e0zp2gux.txt plain text: cord-023721-e0zp2gux.txt item: #70 of 427 id: cord-023728-fgcldn4e author: Bower, John title: Croup in Children (Acute Laryngotracheobronchitis) date: 2014-10-31 words: 3891 flesch: 47 summary: A small proportion of all influenza illnesses among children is associated with croup, but among croup cases, influenza accounts for 1% to 10% of cases depending on the year and circulating strain. The human coronaviruses (hCoV) have been identified in up to 7% of young children with acute respiratory tract infections, with the NL63 strain most often associated with croup. keywords: airway; cases; children; croup; parainfluenza; stridor; tract; years cache: cord-023728-fgcldn4e.txt plain text: cord-023728-fgcldn4e.txt item: #71 of 427 id: cord-023942-vrs3je1x author: Powers, Karen S. title: Acute Pulmonary Infections date: 2011-12-16 words: 11280 flesch: 40 summary: High risk children include those with sickle cell disease and other types of functional asplenia, human immunodefi ciency syndrome, primary immunodefi ciency, children receiving immunosuppressive therapy, and children with chronic pulmonary or cardiac disease. I N FECTIONS high risk children who need expanded serotype coverage. keywords: acute; age; bacterial; bronchiolitis; care; cause; children; disease; infants; infections; infl; lung; pneumonia; pulmonary; respiratory; rsv; treatment; uenza; ventilation; virus; years cache: cord-023942-vrs3je1x.txt plain text: cord-023942-vrs3je1x.txt item: #72 of 427 id: cord-024183-1mrdjc39 author: Hutchison, Alastair A. title: The Respiratory System date: 2013-10-08 words: 28100 flesch: 39 summary: and Flow/Volume Control In adult humans the glottis opens maximally during inspiration, closes gradually to a minimum about three quarters through expiration, and then opens again in late expiration (England et al. 1982a ). (From O'Connor, D. Reproduced with permission from Myer et al. keywords: adults; age; airway; asthma; bpd; breathing; changes; chest; children; closure; compliance; disease; et al; expiratory; fev; flow; frc; function; growth; increase; infants; inspiratory; life; lung; lung function; lung volume; mechanics; muscle; patients; pressure; preterm; pulmonary; resistance; scoliosis; system; ventilation; volume; wall; years cache: cord-024183-1mrdjc39.txt plain text: cord-024183-1mrdjc39.txt item: #73 of 427 id: cord-024188-d7tnku8z author: Nissen, Michael D. title: Respiratory Infections date: 2010-03-27 words: 5270 flesch: 37 summary: Laboratory diagnosis of respiratory virus infections requires specimens containing cells from the respiratory tract collected early in the clinical illness. Limited data is available suggesting that flocked swabs are superior to traditional swabs for detecting respiratory virus infections. keywords: cause; children; disease; human; infection; influenza; patients; pcr; pneumonia; rsv; tract; viruses cache: cord-024188-d7tnku8z.txt plain text: cord-024188-d7tnku8z.txt item: #74 of 427 id: cord-026005-f2khcjdy author: López, Alfonso title: Respiratory System, Mediastinum, and Pleurae date: 2017-02-17 words: 57351 flesch: 32 summary: Lung disease can have profound systemic effects when cytokines, produced locally during necrosis or inflammation, are released into circulation. Alveolar filling disorders are a heterogeneous group of lung diseases characterized by accumulation of various chemical compounds in the alveolar lumens. keywords: acute; air; alveolar; alveoli; animals; bacterial; beings; blood; bovine; bronchi; bronchopneumonia; cases; cats; cattle; cause; cavity; cells; chronic; common; disease; dogs; edema; emphysema; exudate; fibrosis; fig; fluid; horses; human; hyperplasia; infection; inflammation; injury; interstitial; lesions; lungs; macrophages; mucosa; nasal; necrosis; neutrophils; pigs; pneumonia; pneumonocytes; present; pulmonary; result; rhinitis; syndrome; system; tissue; type; viral; virus cache: cord-026005-f2khcjdy.txt plain text: cord-026005-f2khcjdy.txt item: #75 of 427 id: cord-027550-yyqsatqw author: Mammas, Ioannis N. title: Update on current views and advances on RSV infection (Review) date: 2020-06-15 words: 7972 flesch: 21 summary: There are several methods for the purification, quantification and Being able to compare severity over time and/or across cohorts is useful in hospital-based QI programmes but also in multi-centre networks, such as PEdSIdEA Understanding the real-world disease burden caused by RSV will facilitate the study of the effectiveness of antivirals and vaccines, once they become available Recent epidemiological data indicate that RSV infection is an important illness in elderly and high-risk adults, with a disease burden similar to that of non-pandemic influenza RSV and immune response Maternal RSV-specific antibodies transmitted transplacentally during the third trimester of pregnancy are related to RSV disease severity in young infants RSV and miRNAs A greater understanding of miRNAs may enable them to be used as biomarkers of severe RSV infection and as novel targets for treatment or prophylaxis of RSV infection RSV and thrombocytosis Thrombocytosis in RSV-positive bronchiolitis does not require routine prophylactic anti-platelet treatment or further investigations RSV and asthma There is compelling evidence that severe respiratory infection induced by RSV is associated with subsequent development of asthma later in childhood Further understanding of the role of RSV in asthma pathogenesis will enable our understanding of the impact of future vaccines against RSV in asthma prevention RSV as a cause of PIBO There are only few reports in the literature of children with PIBO secondary to RSV as a single infection Further research is required in order to investigate the potential impact of RSV co-infection in the severity and worse outcome in children with PIBO Imaging of RSV infection Although imaging cannot diagnose RSV infection, it is important to identify the possible pattern of viral disease, in order to avoid unnecessary administration of antibiotic therapy and predict possible late effects Standard radiological techniques, including cT, are unable to distinguish between acute bronchiolitis caused by RSV versus that caused by other respiratory viruses HRcT of the lungs may be required to assess possible bronchial thickening and remodeling, the development of bronchiectasis and air-trapping Antivirals against RSV Ribavirin is currently the only licensed antiviral medication used to treat RSV infection; it has very limited efficacy and multiple toxicities, which means its use is usually reserved for severely immunocompromised children due to ethical and technical constraints human challenge models are only undertaken in adults, but if a product is shown to be efficacious in this setting it allows a faster move to trials in children than traditional trials which often take much longer to do A greater understanding of individual data in newly developed pharmaceutical agents against RSV will potentially lead to future personalized treatment regimens RSV and PIcU HFNc might have a role as a rescue therapy for children with RSV-positive bronchiolitis admitted to PIcU to reduce their requirement for high-cost intensive care Heliox could be useful in addition to standard medical care in the management of children with RSV-positive bronchiolitis admitted to PIcU characterization of miRNA expression profiles in biofluids, whole blood samples and tissue samples obtained in in vivo studies (55) . key: cord-027550-yyqsatqw authors: Mammas, Ioannis N.; Drysdale, Simon B.; Rath, Barbara; Theodoridou, Maria; Papaioannou, Georgia; Papatheodoropoulou, Alexia; koutsounaki, Eirini; Koutsaftiki, Chryssie; Kozanidou, Eleftheria; Achtsidis, Vassilis; Korovessi, Paraskevi; Chrousos, George P.; Spandidos, Demetrios A. title: Update on current views and advances on RSV infection (Review) date: 2020-06-15 journal: Int J Mol Med DOI: 10.3892/ijmm.2020.4641 sha: doc_id: 27550 cord_uid: yyqsatqw Respiratory syncytial virus (RSV) infection represents an excellent paradigm of precision medicine in modern paediatrics and several clinical trials are currently performed in the prevention and management of RSV infection. keywords: acute; asthma; bronchiolitis; care; children; development; disease; infants; infection; influenza; prevention; risk; rsv; severity; thrombocytosis; vaccines; virus; wheezing cache: cord-027550-yyqsatqw.txt plain text: cord-027550-yyqsatqw.txt item: #76 of 427 id: cord-027693-a4up394g author: Sampol, Júlia title: Predictors of respiratory complications in patients with C5–T5 spinal cord injuries date: 2020-06-24 words: 3023 flesch: 36 summary: Respiratory complications were frequent (53%) and were associated to longer hospital stay: 83.1 (61.3) and 45.3 (28.1) days in patients with and without respiratory complications (p < 0.001). Respiratory complications are common in patients with spinal cord injuries and their presence predicts worse prognosis and increases health care costs keywords: complications; cord; injuries; injury; patients; spinal; thoracic cache: cord-027693-a4up394g.txt plain text: cord-027693-a4up394g.txt item: #77 of 427 id: cord-048197-9785vg6d author: Domachowske, Joseph B title: Gene expression in epithelial cells in response to pneumovirus infection date: 2001-05-11 words: 4694 flesch: 30 summary: Respiratory syncytial virus and human bronchial epithelium Host responses to respiratory virus infection and immunization Epithelial regulation of innate immunity to respiratory syncytial virus Interleukin-8 expression in normal nasal epithelium and its modulation by infection with respiratory syncytial virus and cytokines tumor necrosis factor, interleukin-1, and interleukin-6 Respiratory syncytial virus increases IL-8 gene expression and protein release in A549 cells Interleukin-8, interleukin-6, and soluble tumour necrosis factor receptor type I release from a human pulmonary epithelial cell line (A549) exposed to respiratory syncytial virus Macrophage inflammatory protein-1α α and RANTES are present in nasal secretions during ongoing upper respiratory tract infection Respiratory syncytial virus-induced chemokine expression in the lower airways: eosinophil recruitment and degranulation Inhibiton of viral replication reverses respiratory syncytial virus-induced NF-κ κB activation and interleukin-8 gene expression in A549 cells Oxidant tone regulates IL-8 production in epithelium infected with respiratory syncytial virus Induction of interlukin (IL)-8 gene expression by respiratory syncytial virus involved activation of nuclear factor (NF)-κ κB and NF-IL-6 Transcriptional activation of the interleukin-8 gene by respiratory syncytial virus infection in alveolar epithelial cells: nuclear translocation of the RelA transcription factor as a mechanism producing airway mucosal inflammation Inducible translational regulation of the NF-IL6 transcription factor by respiratory syncytial virus infection in pulmonary epithelial cells Activator protein-1 is the preferred transcription factor for cooperative interaction with nuclear factor-κ κB in respiratory syncytial virus-induced interleukin-8 gene expression in airway epithelium Incomplete regulation of NF-κ κB by Iκ κBα α during respiratory syncytial virus infection in A549 cells Requirement of a novel upstream response element in respiratory syncytial virus-induced IL-8 gene expression Virus-inducible expression of a host chemokine gene relies on replication-linked mRNA stabilization Cell-specific expression of RANTES, MCP-1, and MIP-1α α by lower airway epithelial cells and eosinophils infected with respiratory syncytial virus [1] observed that explanted respiratory epithelial cells slow their ciliary beat frequency almost immediately after exposure to RSV, with complete ciliostasis seen as early as 6 h after the initial infection. keywords: cells; expression; gene; il-8; infection; mip-1α; response; rsv; virus cache: cord-048197-9785vg6d.txt plain text: cord-048197-9785vg6d.txt item: #78 of 427 id: cord-048447-chz8luni author: Duffett, Mark title: Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysis date: 2007-06-15 words: 3999 flesch: 33 summary: We selected search terms from the keywords and MESH terms of previous surfactant trials and from the generic and brand names of commercially available surfactants. We searched the MEDLINE, EMBASE, CINAHL and Ovid Healthstar databases, the bibliographies of included trials and review articles, conference proceedings and trial registries. keywords: acute; children; failure; patients; surfactant; trials; ventilation cache: cord-048447-chz8luni.txt plain text: cord-048447-chz8luni.txt item: #79 of 427 id: cord-129086-ra2njvcz author: Kumar, Sanjay title: The perspective of fluid flow behavior of respiratory droplets and aerosols through the facemasks in context of SARS-CoV-2 date: 2020-10-10 words: 8131 flesch: 48 summary: While these experimental studies are essential for the broad characterization and design evaluation of respiratory facemasks, further theoretical and numerical methods and algorithm-based investigations provide a better insight into the facemask's fluid flow dynamics and the droplet leakage through the facemask openings. The filtration mechanism of N95 facemasks operates on three possible principles: diffusion, inertial impaction, and electrostatic attraction. keywords: air; droplets; efficiency; equations; facemasks; filtration; flow; fluid; n95; particles; rate; resistance; transmission; use; velocity; virus; wearing cache: cord-129086-ra2njvcz.txt plain text: cord-129086-ra2njvcz.txt item: #80 of 427 id: cord-151024-qe7c2uks author: Koca, Caglar title: Molecular Communication Theoretical Modeling and Analysis of SARS-CoV2 Transmission in Human Respiratory System date: 2020-11-07 words: 5634 flesch: 48 summary: Note that, since bound ACE2 receptors downregulate, large N (y) only case cannot be modelled as a linear time invariant system. These results are especially important to understand the effect of SARS-CoV2 on the different human populations at different ages who have different mucus flow rates and ACE2 receptor concentrations in the different regions of the respiratory tract. keywords: ace2; binding; cov2; human; mucus; receptor; sars; system; tract; virus; viruses cache: cord-151024-qe7c2uks.txt plain text: cord-151024-qe7c2uks.txt item: #81 of 427 id: cord-225826-bwghyhqx author: Jiang, Zheng title: Combining Visible Light and Infrared Imaging for Efficient Detection of Respiratory Infections such as COVID-19 on Portable Device date: 2020-04-15 words: 4814 flesch: 53 summary: In this paper, we propose a remote, potable and intelligent health screening system based on respiratory data for pre-screening and auxiliary diagnosis of respiratory diseases like COVID-19. During the analysis of respiratory data, the entire waveform in time sequence should be taken into consideration. keywords: breathing; data; face; masks; network; people; respiration; respiratory; screening; time cache: cord-225826-bwghyhqx.txt plain text: cord-225826-bwghyhqx.txt item: #82 of 427 id: cord-251986-ajlpb9li author: Li, Yan‐Chao title: The neuroinvasive potential of SARS‐CoV2 may play a role in the respiratory failure of COVID‐19 patients date: 2020-03-11 words: 2255 flesch: 32 summary: A first step in understanding SARS pathogenesis Expression of CD26 (dipeptidyl peptidase IV) on resting and activated human T-lymphocytes The multifunctional or moonlighting protein CD26/DPPIV Persistent infection of SARS coronavirus in colonic cells in vitro The clinical pathology of severe acute respiratory syndrome (SARS): a report from Dipeptidyl peptidase IV, which probably plays important roles in alzheimer disease (AD) pathology, is upregulated in AD brain neurons and associates with amyloid plaques Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways Multiple organ infection and the pathogenesis of SARS Detection of severe acute respiratory syndrome coronavirus in the brain: potential role of the chemokine mig in pathogenesis Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2 Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus The vagus nerve is one route of transneural invasion for intranasally inoculated influenza a virus in mice Morphogenesis of avian infectious bronchitis virus in primary chick kidney cells Microbes Infect From SARS to MERS, thrusting coronaviruses into the spotlight Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains Coronavirus spike protein and tropism changes Coronavirus infection of rat dorsal root ganglia: ultrastructural characterization of viral replication, transfer, and the early response of satellite cells Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Novel coronavirus is putting the whole world on alert Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Middle East respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4 Neurotropism of human coronavirus 229E Axonal transport enables neuron-to-neuron propagation of human coronavirus OC43 Hepatitis E virus infects neurons and brains Neurotropic virus tracing suggests a membranous-coating-mediated mechanism for transsynaptic communication Characteristics of a coronavirus (strain 67N) of pigs Immunofluorescence studies on the pathogenesis of hemagglutinating encephalomyelitis virus infection in pigs after oronasal inoculation Exploring the pathogenesis of severe acute respiratory syndrome (SARS): the tissue distribution of the coronavirus (SARS-CoV) and its putative receptor, angiotensin-converting enzyme 2 (ACE2) Quantitative temporal-spatial distribution of severe acute respiratory syndromeassociated coronavirus (SARS-CoV) in post-mortem tissues Cleavage of the SARS coronavirus spike glycoprotein by airway proteases enhances virus entry into human bronchial epithelial cells in vitro A novel angiotensinconverting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. keywords: coronavirus; cov; infection; mers; patients; sars cache: cord-251986-ajlpb9li.txt plain text: cord-251986-ajlpb9li.txt item: #83 of 427 id: cord-252012-hdjbxah8 author: McErlean, Peter title: Viral diversity in asthma: Immunology and Allergy Clinics of North America: Asthma and Infectious Disease date: 2010-11-01 words: 5502 flesch: 32 summary: 252012 cord_uid: hdjbxah8 Asthma exacerbations are precipitated primarily by respiratory virus infection and frequently require immediate medical intervention. Nevertheless, the disparity in viral detection between the asthmatic and control groups may imply some mechanism of either persistence in asthmatics or an association with the long-term compliance of glucocorticoid therapy and inhibition of symptoms during respiratory virus infection. keywords: ari; asthma; bocavirus; children; exacerbations; hbov; infection; kipyv; studies; viruses; wupyv cache: cord-252012-hdjbxah8.txt plain text: cord-252012-hdjbxah8.txt item: #84 of 427 id: cord-252037-rj61mzqj author: Gerna, G. title: Changing circulation rate of human metapneumovirus strains and types among hospitalized pediatric patients during three consecutive winter-spring seasons date: 2005-06-28 words: 2210 flesch: 33 summary: Statistical differences in the circulation rate of respiratory virus infections among the 3 consecutive seasons were determined by the chi square test. Within the aliquot of patients found positive for some respiratory virus, no difference in the circulation rate was observed for respiratory virus infections caused by influenzavirus B, hPIVs, hAdVs, hCoVs, and coinfections along the three years studied. keywords: circulation; hmpv; hrsv; human; infections; patients cache: cord-252037-rj61mzqj.txt plain text: cord-252037-rj61mzqj.txt item: #85 of 427 id: cord-253145-1fbj1rdv author: Fox, Julie D. title: Nucleic acid amplification tests for detection of respiratory viruses date: 2007-10-31 words: 5393 flesch: 28 summary: The method has been applied successfully to respiratory virus detection and diagnosis of associated infection and disease Hibbitts and Fox, 2002; Moore et al., 2004; Landry et al., 2005; Lee et al., 2006; Loens et al., 2006; Moore et al., 2006; Dare et al., 2007) . van Elden et al., 2002; Erdman et al., 2003; Coiras et al., 2004; Coyle et al., 2004; Jennings et al., 2004; Syrmis et al., 2004; Weinberg et al., 2004; Lee et al., 2006 PIV 4 Not detectable routinely except by NAT. keywords: acid; amplification; culture; detection; et al; lee et; nats; nucleic; pcr; virus; viruses cache: cord-253145-1fbj1rdv.txt plain text: cord-253145-1fbj1rdv.txt item: #86 of 427 id: cord-253148-3t4o27xp author: Chow, Brian D.W. title: Evidence of human bocavirus circulating in children and adults, Cleveland, Ohio date: 2008-09-19 words: 2702 flesch: 46 summary: To define the clinical and epidemiologic characteristics in adult and pediatric patients with evidence of HBoV. STUDY DESIGN: From October 2005 through October 2006, we screened respiratory samples from children and adults negative for common respiratory pathogens for HBoV by PCR. The 12-18 month age group had the highest prevalence, with HBoV detected in 6.0% of respiratory samples screened (Fig. 2) . keywords: children; hbov; human; patients; pediatric; samples cache: cord-253148-3t4o27xp.txt plain text: cord-253148-3t4o27xp.txt item: #87 of 427 id: cord-253223-us0ey8dq author: Chow, Brian D.W. title: The Human Bocaviruses: A Review and Discussion of Their Role in Infection date: 2009-11-03 words: 5931 flesch: 43 summary: Gastrointestinal symptoms are reported in up to 25% of patients who have HBoV-1 respiratory infection (see Table 2 ) suggesting HBoV-1 may not be limited to the respiratory tract alone. When in vitro culture systems and animal models are available, a better understanding of the role of HBoV-1 in human respiratory disease can be established. keywords: bocavirus; children; detection; disease; hbov-1; human; infection; patients; samples; studies; tract cache: cord-253223-us0ey8dq.txt plain text: cord-253223-us0ey8dq.txt item: #88 of 427 id: cord-253279-8j7esl8j author: Wasserman, Richard L. title: RI-002, an intravenous immunoglobulin containing high titer neutralizing antibody to RSV and other respiratory viruses for use in primary immunodeficiency disease and other immune compromised populations date: 2017-10-16 words: 8772 flesch: 35 summary: A study was conducted to compare RSV neutralizing antibody titers in multiple lots of RI-002 to titers from a single available lot of RI-001. Although limited in size, these studies demonstrate that RI-002 achieves high RSV neutralizing antibody titers that can be considered protective in humans and could result in improved outcomes in RSV-infected patients when treatment begins soon after the onset of symptoms. keywords: animals; antibodies; antibody; infection; neutralizing; patients; ri-002; rsv; study; titers; treatment; virus cache: cord-253279-8j7esl8j.txt plain text: cord-253279-8j7esl8j.txt item: #89 of 427 id: cord-253502-v2hh3w3r author: Leung, C.W. title: Clinical picture, diagnosis, treatment and outcome of severe acute respiratory syndrome (SARS) in children date: 2004-11-05 words: 8632 flesch: 40 summary: Important questions to ask in the 'peace time' include: (1) history of recent travel to pre-viously SARS-affected areas or areas with an increased likelihood of animal to human transmission of SARS-CoV infection; (2) close contact with a suspected SARS patient; (3) history of recent hospitalisation or contact with a healthcare facility; (4) individuals who are either healthcare workers or laboratory workers with potential exposure to SARS patients or live SARS-CoV; and (5) link to a cluster of cases of unexplained respiratory illness in the community. Sputum specimens appear to have a higher diagnostic yield but productive cough is uncommon in SARS patients in the early phase of illness and sputum is difficult to obtain in children. keywords: acute; adults; children; clinical; coronavirus; cov; diagnosis; disease; illness; infection; patients; pcr; sars; severe; syndrome; treatment cache: cord-253502-v2hh3w3r.txt plain text: cord-253502-v2hh3w3r.txt item: #90 of 427 id: cord-253761-wjm8ju3v author: Haidopoulou, Katerina title: Human bocavirus infections in hospitalized Greek children date: 2010-03-09 words: 2016 flesch: 47 summary: To define the epidemiological profile and the clinical characteristics associated with HBoV infection in a population of children hospitalized with respiratory tract infection. HBoV infections occur in Greece mostly among very young children. keywords: bocavirus; children; hbov; human; infection cache: cord-253761-wjm8ju3v.txt plain text: cord-253761-wjm8ju3v.txt item: #91 of 427 id: cord-254265-8i86c8kt author: Camps, Marta title: Prevalence of human metapneumovirus among hospitalized children younger than 1 year in Catalonia, Spain date: 2008-06-12 words: 4573 flesch: 34 summary: Integrated software for molecular evolutionary genetics analysis an sequence alignment Detection of human metapneumovirus in clinical samples by immunofluorescence staining of shell vial centrifugation cultures prepared from three different cell lines Realtime reverse transcriptase PCR assay for detection of human metapneumoviruses from all known genetic lineages Reducing the impact of viral respiratory infections in children Respiratory tract reinfections by the new human Metapneumovirus in an immunocompromised child Rapid detection of human metapneumovirus strains in nasopharyngeal aspirates and shell vial cultures by monoclonal antibodies Characterization of human metapneumoviruses isolated from patients in North America Detection and typing by molecular techniques of respiratory viruses in children hospitalized for acute respiratory infection in First detection of human metapneumovirus in children with acute respiratory infection in India: A preliminary report Detection and pathogenicity of human metapneumovirus respiratory infection in pediatric Italian patients during a winterspring season Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis Bronchiolitis-associated hospitalizations among US children A newly discovered human pneumovirus isolated from young children with respiratory tract disease Absence of human metapneumovirus co-infection in cases of severe respiratory syncytial virus infection Ten years' experience with year-round active surveillance of up to 19 respiratory pathogens in children Estimates of world-wide distribution of child deaths from acute respiratory infections Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children Although some studies have detected human metapneumovirus in all age groups, human metapneumovirus infections could be more severe in children, elderly, and immunocompromised patients [Pelletier et al., 2002; Bastien et al., 2003; Cane et al., 2003; Falsey et al., 2003] . keywords: children; et al; human; infection; metapneumovirus; patients; pcr; study; tract; viruses cache: cord-254265-8i86c8kt.txt plain text: cord-254265-8i86c8kt.txt item: #92 of 427 id: cord-254766-585iu5ey author: Tauro, Sharyn title: Molecular and cellular mechanisms in the viral exacerbation of asthma date: 2008-08-13 words: 5254 flesch: 34 summary: The dynamics that contribute to disease pathogenesis are multifactorial and involve overlapping molecular and cellular mechanisms, particularly the immune response to respiratory virus infection or allergen sensitization. Many small animal models were designed to reveal the pathogenic mechanisms behind the enhancement of allergic sensitization by respiratory virus infections; the increased airway inflammation and responsiveness resulting from allergic airway sensitization following respiratory viral infection and, in those with established allergic airway sensitization, the increased airway inflammation and responsiveness due to respiratory viral infections. keywords: airway; asthma; cells; disease; exacerbation; infection; inflammation; mice; response; rsv; th2; virus cache: cord-254766-585iu5ey.txt plain text: cord-254766-585iu5ey.txt item: #93 of 427 id: cord-254770-ot9ys10r author: Uçkay, Ilker title: Low incidence of severe respiratory syncytial virus infections in lung transplant recipients despite the absence of specific therapy date: 2009-10-17 words: 2669 flesch: 32 summary: A single-season prospective study of respiratory viral infections in lung transplant recipients Community respiratory viruses: organ transplant recipients Community acquired respiratory viral infections after lung transplantation: clinical features and long-term consequences Community-acquired respiratory viruses Clinical features and outcomes of paramyxoviral infection in lung transplant recipients treated with ribavirin Community respiratory viral infection in adult lung transplant recipients Intravenous ribavirin is a safe and cost-effective treatment for respiratory syncytial virus infection after lung transplantation Respiratory virus infection among hematopoietic cell transplantation recipients: evidence for asymptomatic parainfluenza virus infection Randomized controlled multicenter trial of aerosolized ribavirin for respiratory syncytial virus upper respiratory tract infection in hematopoietic cell transplant recipients Preemptive treatment of pediatric bone marrow transplant patients with asymptomatic respiratory syncytial virus infection with aerosolized ribavirin Respiratory virus infections after stem cell transplantation: a prospective study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation Community respiratory virus infections among hospitalized adult bone marrow transplant recipients Community-acquired respiratory viruses after hemopoietic stem cell or solid organ transplantation Respiratory syncytial virus upper respiratory tract illnesses in adult blood and marrow transplant recipients: combination therapy with aerosolized ribavirin and intravenous immunoglobulin Frequent detection of respiratory viruses in adult recipients of stem cell transplants with the use of real-time polymerase chain reaction, compared with viral culture Immune-globulin prophylaxis of respiratory syncytial virus infection in patients undergoing stem-cell transplantation Pre-emptive oral ribavirin therapy of paramyxovirus infections after haematopoietic stem cell transplantation: a pilot study Respiratory syncytial virusassociated infections in adult recipients of solid organ transplants Management of infections caused by respiratory syncytial virus Respiratorisches Syncytial-Virus (RSV) Infektion: Massnahmen beim immunsupprimierten Patienten Lower respiratory viral illnesses: improved diagnosis by molecular methods and clinical impact A prospective hospital-based study of the clinical impact of non-severe acute respiratory syndrome (non-SARS)-related human coronavirus infection The value of polymerase chain reaction for the diagnosis of viral respiratory tract infections in lung transplant recipients Development of a quantitative TaqMan RT-PCR for respiratory syncytial virus Revision of the 1990 working formulation for the classification of pulmonary allograft rejection CT manifestations of respiratory syncytial virus infection in lung transplant recipients Respiratory viral infections in lung transplant recipients: radiologic findings with clinical correlation Incidence and significance of noncytomegalovirus viral respiratory infection after adult lung transplantation Respiratory viral infections are a distinct risk for bronchiolitis obliterans syndrome and death Respiratory viruses and chronic rejection in lung transplant recipients Intrainfusion and postinfusion adverse events related to intravenous immunoglobulin therapy in immunodeficiency states Adverse reactions of prophylactic intravenous immunoglobulin infusions in Iranian patients with primary immunodeficiency Ribavirin: adverse drug reactions Phase 1 evaluation of the respiratory syncytial virus-specific monoclonal antibody palivizumab in recipients of hematopoietic stem cell transplants Results of clinical surveillance during the Japanese first palivizumab season in 2002-2003 Common adverse events associated with the use of ribavirin for severe acute respiratory syndrome in Canada Efficacy of oral ribavirin in lung transplant recipients with respiratory syncytial virus lower respiratory tract infection Palivizumab for respiratory syncytial virus prophylaxis in high-risk infants: a costeffectiveness analysis Cost effectiveness of palivizumab for respiratory syncytial virus prophylaxis in high-risk children: a UK analysis American Academy of Pediatrics Committee on Infectious Diseases and Committee on Fetus and Newborn. We retrospectively reviewed cases of lower respiratory tract RSV infections in adult LTRs. keywords: infections; patients; recipients; rsv; transplant; virus cache: cord-254770-ot9ys10r.txt plain text: cord-254770-ot9ys10r.txt item: #94 of 427 id: cord-255011-7oqfod62 author: Erles, Kerstin title: Canine Respiratory Coronavirus: An Emerging Pathogen in the Canine Infectious Respiratory Disease Complex date: 2008-05-22 words: 3765 flesch: 49 summary: Most commonly, however, infectious respiratory disease in dogs has a multifactorial etiology and is best described as canine infectious respiratory disease (CIRD) complex (also known as 'kennel cough'). Canine distemper: re-emergence of an old enemy SV-5-like parainfluenza virus in dogs Association of canine adenovirus (Toronto A 26/ 61) with an outbreak of laryngotracheitis ('kennel cough'): a preliminary report Canine tracheobronchitis: isolation and characterization of the agent with experimental reproduction of the disease Transmission of equine influenza virus to dogs Bordetella and mycoplasma respiratory infections in dogs and cats Mycoplasmas associated with canine infectious respiratory disease The association of streptococcus equi subsp. keywords: canine; coronavirus; crcov; disease; dogs; respiratory; samples cache: cord-255011-7oqfod62.txt plain text: cord-255011-7oqfod62.txt item: #95 of 427 id: cord-255166-sar50ej0 author: Stone, Sophia title: Respiratory disease in pregnancy date: 2007-05-07 words: 4654 flesch: 42 summary: Most reported series of pregnancies in women with CF have shown that with careful planning and close monitoring by a dedicated CF team, pregnancy outcomes are favourable. There are few data regarding pregnancy outcome in women following lung transplant. keywords: asthma; chest; delivery; disease; pneumonia; pregnancy; presence; risk; treatment; women cache: cord-255166-sar50ej0.txt plain text: cord-255166-sar50ej0.txt item: #96 of 427 id: cord-255623-qdpdsye9 author: Pham, Hien T. title: Clinical and Pathogenic Characteristics of Lower Respiratory Tract Infection Treated at the Vietnam National Children's Hospital date: 2020-03-11 words: 2709 flesch: 41 summary: respiratory viral panel fast for diagnosis of respiratory virus infections Mini-symposium: microbiological diagnostic procedures in respiratory infection respiratory virus infection Access to a polymerase chain reaction assay method targeting 13 respiratory viruses can reduce antibiotics: a randomised, controlled trial Diagnostic errors that lead to inappropriate antimicrobial use Multiplex PCR and emerging technologies for the detection of respiratory pathogens Assessment of the usefulness of multiplex real-time PCR tests in the diagnostic and therapeutic process of pneumonia in hospitalized children: a single-center experience Comparison of the Luminex xTAG respiratory viral panel with in-house nucleic acid amplification tests for diagnosis of respiratory virus infections Fully automated nucleic acid extraction: MagNA Pure LC Human bocavirus in children with acute respiratory infections in Vietnam Cellular immunity and lung injury in respiratory virus infection Respiratory syncytial virus infection Pathogen screening and prognostic factors in children with severe ARDS of pulmonary origin Respiratory syncytial virus infections: recent prospects for control Association between C-reactive protein and metabolic syndrome in Korean adults C-reactive protein: ligands, receptors and role in inflammation keywords: children; infections; pcr; tract; viruses; xtag cache: cord-255623-qdpdsye9.txt plain text: cord-255623-qdpdsye9.txt item: #97 of 427 id: cord-255711-8lojw5cz author: Palmu, Arto A. title: Nasal swab bacteriology by PCR during the first 24‐months of life: A prospective birth cohort study date: 2019-01-04 words: 2021 flesch: 28 summary: Pediatr Pulmonol DOI: 10.1002/ppul.24231 sha: doc_id: 255711 cord_uid: 8lojw5cz BACKGROUND: Most respiratory bacterial carriage studies in children are based on cross‐sectional samples or longitudinal studies with infrequent sampling points. 1 Carriage of respiratory bacterial pathogens, such as Streptococcus pneumoniae, Moraxella catarrhalis, and Haemophilus influenzae, is a prerequisite for two important childhood ARIs; acute otitis media, which is the most frequently reported pediatric bacterial infection, 2 and bacterial pneumonia, a leading cause of childhood deaths. keywords: carriage; children; pcr; pneumoniae; streptococcus; study cache: cord-255711-8lojw5cz.txt plain text: cord-255711-8lojw5cz.txt item: #98 of 427 id: cord-255734-038xu4hq author: Taylor, Deborah R. title: Obstacles and advances in SARS vaccine development date: 2006-02-13 words: 5338 flesch: 42 summary: A novel coronavirus associated with severe acute respiratory syndrome SARS-beginning to understand a new virus Severe acute respiratory syndrome coronavirus phylogeny: toward consensus Identification of a new human coronavirus Coronaviridae: the viruses and their replication Lung pathology of fatal severe acute respiratory syndrome SARS coronavirus-infected cells in lung detected by new in situ hybridization technique Expression of lymphocytes and lymphocyte subsets in patients with severe acute respiratory syndrome Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome Significant changes of peripheral T lymphocyte subsets in patients with severe acute respiratory syndrome SARS-related virus predating SARS outbreak Dissection study on the severe acute respiratory syndrome 3C-like protease reveals the critical role of the extra domain in dimerization of the enzyme: defining the extra domain as a new target for design of highly specific protease inhibitors SARS in newborns and children Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China Role of China in the quest to define and control severe acute respiratory syndrome Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice Mice susceptible to SARS coronavirus Contributions of the structural proteins of severe acute respiratory syndrome coronavirus to protective immunity Mechanisms of host defense following severe acute respiratory syndromecoronavirus (SARS-CoV) pulmonary infection of mice Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1 Virology: SARS virus infection of cats and ferrets Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets Mucosal immunisation of African green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS Koch's postulates fulfilled for SARS virus Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome Macaque model for severe acute respiratory syndrome Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys Protection of chickens after live and inactivated virus vaccination against challenge with nephropathologenic infectious bronchitis virus Safety and efficacy of a modified-live canine coronavirus vaccine in dogs Antibody-mediated enhancement of disease in feline infectious peritonitis: comparisons with dengue hemorrhagic fever Inactivated hepatitis A vaccine: active and passive immunoprophylaxis in chimpanzees Live attenuated varicella vaccine Highly infectious SARS-CoV pseudotyped virus reveals the cell tropism and its correlation with receptor expression Genetically engineered vaccines: an overview Developing new smallpox vaccines Current status and future trends in vaccine regulation-USA SARS-associated coronavirus quasispecies in individual patients SARS associated coronavirus has a recombinant polymerase and coronaviruses have a history of host-shifting Mosaic evolution of the severe acute respiratory syndrome coronavirus Antibody-dependent enhancement of virus infection and disease The role of IgG subclass of mouse monoclonal antibodies in antibody-dependent enhancement of feline infectious peritonitis virus infection of feline macrophages Localization of antigenic sites of the S glycoprotein of feline infectious peritonitis virus involved in neutralization and antibody-dependent enhancement Antibody-dependent enhancement of feline infectious peritonitis virus infection in feline alveolar macrophages and human monocyte cell line U937 by serum of cats experimentally or naturally infected with feline coronavirus Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study Development and characterisation of neutralising monoclonal antibody to the SARS-coronavirus Identification of an antigenie determinant on the S2 domain of the severe acute respiratory syndrome coronavirus spike glycoprotein capable of inducing neutralizing antibodies Synthesis and characterization of a native, oligomeric form of recombinant severe acute respiratory syndrome coronavirus spike glycoprotein Inactivation of the coronavirus that induces severe acute respiratory syndrome, SARS-CoV Subcutaneously injected UV-inactivated SARS coronavirus vaccine elicits systemic humoral immunity in mice Inactivated SARS-CoV vaccine prepared from whole virus induces a high level of neutralizing antibodies in BALB/c mice Immune responses in Balb/c mice induced by a candidate SARS-CoV inactivated vaccine prepared from F69 strain Assembly of human severe acute respiratory syndrome coronavirus-like particles Severe acute respiratory syndrome coronavirus spike protein expressed by attenuated vaccinia virus protectively immunizes mice Immunization with modified vaccinia virus Ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets Effects of a SARS-associated coronavirus vaccine in monkeys Retroviral vectors pseudotyped with severe acute respiratory syndrome coronavirus S protein Induction of SARS-nucleoprotein-specific immune response by use of DNA vaccine DNA vaccine of SARS-CoV S gene induces antibody response in mice A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments Generation and characterization of DNA vaccines targeting the nucleocapsid protein of severe acute respiratory syndrome coronavirus Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus SARS CTL vaccine candidates; HLA supertype-, genome-wide scanning and biochemical validation Kanta Subbarao, Edward Tabor, Miriam Darnell, Robin Levis and Hira Nakhasi are gratefully acknowledged for comments on the manuscript. [12] noted that a rapid decline of T-cell subsets in the periphery was observed in patients during the acute phase of SARS infection, but they observed restoration of T cells during recovery. keywords: animal; coronavirus; cov; disease; infection; mice; protein; sars; syndrome; vaccine; virus cache: cord-255734-038xu4hq.txt plain text: cord-255734-038xu4hq.txt item: #99 of 427 id: cord-255901-nl9k8uwd author: Barasheed, Osamah title: Uptake and effectiveness of facemask against respiratory infections at mass gatherings: a systematic review date: 2016-03-29 words: 4523 flesch: 42 summary: key: cord-255901-nl9k8uwd authors: Barasheed, Osamah; Alfelali, Mohammad; Mushta, Sami; Bokhary, Hamid; Alshehri, Jassir; Attar, Ammar A.; Booy, Robert; Rashid, Harunor title: Uptake and effectiveness of facemask against respiratory infections at mass gatherings: a systematic review date: 2016-03-29 journal: Int J Infect Dis DOI: 10.1016/j.ijid.2016.03.023 sha: doc_id: 255901 cord_uid: nl9k8uwd OBJECTIVES: The risk of acquisition and transmission of respiratory infections is high among attendees of mass gatherings (MGs). keywords: effectiveness; facemask; hajj; infections; influenza; pilgrims; respiratory; studies; study; uptake cache: cord-255901-nl9k8uwd.txt plain text: cord-255901-nl9k8uwd.txt item: #100 of 427 id: cord-256065-zz2907h0 author: Barral-Arca, Ruth title: A Meta-Analysis of Multiple Whole Blood Gene Expression Data Unveils a Diagnostic Host-Response Transcript Signature for Respiratory Syncytial Virus date: 2020-03-06 words: 5659 flesch: 35 summary: PI19/01090/Cofinanciado FEDER) given to F.M.-T. Biomarkers of respiratory syncytial virus (RSV) infection: Specific neutrophil and cytokine levels provide increased accuracy in predicting disease severity Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: A systematic review and modelling study Whole blood gene expression in infants with respiratory syncytial virus bronchiolitis Risk of primary infection and reinfection with respiratory syncytial virus Review of epidemiology and clinical risk factors for severe respiratory syncytial virus (RSV) infection Risk factors in children hospitalized with RSV bronchiolitis versus non-RSV bronchiolitis The burden of respiratory syncytial virus infection in young children Whole Exome Sequencing reveals new candidate genes in host genomic susceptibility to Respiratory Syncytial Virus Disease Increased concordance of severe respiratory syncytial virus infection in identical twins Disease severity in respiratory syncytial virus infection: Role of host genetic variation Respiratory Syncytial Virus Bronchiolitis in Children up to 5 Years of Age in Spain: Epidemiology and Comorbidities: An Observational Study Diagnosis of childhood tuberculosis and host RNA expression in Africa Diagnostic Test Accuracy of a 2-Transcript Host RNA Signature for Discriminating Bacterial vs Viral Infection in Febrile Children Whole blood gene expression profiles to assess pathogenesis and disease severity in infants with respiratory syncytial virus infection A 2-transcript host cell signature distinguishes viral from bacterial diarrhea and it is influenced by the severity of symptoms A qPCR expression assay of IFI44L gene differentiates viral from bacterial infections in febrile children Diagnosis of Kawasaki disease using a minimal whole-blood gene expression signature Gene expression and regulation in systemic lupus erythematosus How to read a systematic review and meta-analysis and apply the results to patient care: Users' guides to the medical literature Power failure: Why small sample size undermines the reliability of neuroscience Genome-wide expression for diagnosis of pulmonary tuberculosis: A multicohort analysis Host-response-based gene signatures for tuberculosis diagnosis: A systematic comparison of 16 signatures A 20-Gene Set Predictive of Progression to Severe Dengue A community approach to mortality prediction in sepsis via gene expression analysis 2 -5 -Oligoadenylate Synthetase-Like Functional enrichment analysis showed several pathways significantly altered, including immunologic response mediated by RSV infection, pattern recognition receptors, cell cycle, and olfactory signaling. keywords: analysis; expression; genes; host; infection; rsv; table; value; virus cache: cord-256065-zz2907h0.txt plain text: cord-256065-zz2907h0.txt item: #101 of 427 id: cord-256788-h4iv8crq author: Sumino, Kaharu title: Antiviral IFN-γ responses of monocytes at birth predict respiratory tract illness in the first year of life date: 2012-03-27 words: 5044 flesch: 40 summary: key: cord-256788-h4iv8crq authors: Sumino, Kaharu; Tucker, Jennifer; Shahab, Muhammad; Jaffee, Katy F.; Visness, Cynthia M.; Gern, James E.; Bloomberg, Gordon R.; Holtzman, Michael J. title: Antiviral IFN-γ responses of monocytes at birth predict respiratory tract illness in the first year of life date: 2012-03-27 journal: J Allergy Clin Immunol DOI: 10.1016/j.jaci.2012.02.033 sha: doc_id: 256788 cord_uid: h4iv8crq BACKGROUND: Viral respiratory tract infections are the leading cause of acute illness during infancy and are closely linked to chronic inflammatory airway diseases later in life. Viral respiratory tract infections are a common cause of early childhood illness. keywords: asthma; cells; ifng; illness; infection; life; mrna; response; rsv; tract; year cache: cord-256788-h4iv8crq.txt plain text: cord-256788-h4iv8crq.txt item: #102 of 427 id: cord-256827-tht5h1tu author: Jain, Neemisha title: Upper respiratory tract infections date: 2001 words: 2742 flesch: 39 summary: Thus, acute respiratory infection constitutes a significant problem in childhood and the majority of these infections are upper respiratory infection. Acute respiratory infection Magnitude of acute respiratory infection in under five Acute respiratory infection in Children-a survey in the rural community An Indian hospital study of viral causes of acute respiratory infections in children Resistant pneumococci: protecting patients through judicious antibiotic use The common coldprinciples of judicious use of antimicrobial agents Principles of judicious use of antimicrobial agents for pediatric upper respiratory infections Acute sinusitisprinciples of judicious use of antimicrobial agents Pharyngitis-Principles of judicious use of antimicrobial agents Frequency and severity of infections in daycare The epidemiology, pathogenesis, and treatment of the common cold Infections of the upper respiratory tract Respiratory viral infection in childhood. keywords: acute; antibiotics; cold; infection; pharyngitis; sinusitis cache: cord-256827-tht5h1tu.txt plain text: cord-256827-tht5h1tu.txt item: #103 of 427 id: cord-256930-bz80uxnx author: Xiao, Ni‐guang title: Prevalence of human metapneumovirus in children with acute lower respiratory infection in Changsha, China date: 2013-01-07 words: 3573 flesch: 44 summary: A 2-year study Human metapneumovirus infection in hospitalized children with acute respiratory disease in Korea Hospitalization rates for human metapneumovirus infection among 0-to-3 year-olds in Gipuzkoa Outbreak of human metapneumovirus infection in Norwegian children Human metapneumovirus infection in the United States: Clinical manifestations associated with a newly emerging respiratory infection in children Presence of the new human metapneumovirus in French children with bronchiolitis Human metapneumovirus in severe respiratory syncytial virus bronchiolitis Human metapneumovirus infections in children Detection of adenovirus in clinical specimens by polymerase chain reaction and liquid-phase hybridization quantitated by time-resolved fluorometry Novel human metapneumovirus sublineage Co-infection of human metapneumovirus with adenovirus or respiratory syncytial virus among children in Japan Human metapneumovirus in children Use of the P gene to genotype human metapneumovirus identifies four viral subtypes Epidemiologic and clinical features of HMPV, RSV and RV infections in young children Human metapneumovirus in children tested at a tertiary-care hospital Role of metapneumovirus in viral respiratory infections in young children Children with respiratory disease associated with metapneumovirus in Hong Kong Characterization of human metapneumoviruses isolated from patients in North America Human metapneumovirus genotypes and severity of disease in young children (n ¼ 100) during a 7-year study in Dijon Hospital, France Development of three multiplex RT-PCR assays for the detection of 12 respiratory RNA viruses Human metapneumovirus RNA in encephalitis patient Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis A newly discovered human pneumovirus isolated from young children with respiratory tract disease Prevalence and clinical symptoms of human metapneumovirus infection in hospitalized patients Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children Prevalence and clinical and molecular characterization of human metapneumovirus in children with acute respiratory infection in China However, limited data exist for hMPV infection, especially concerning its prevalence, and molecular and clinical characterizations of hMPV in children with lower respiratory tract infections in China, with the exception of a previous study in Lanzhou City [Xiao et al., 2010] . keywords: children; et al; hmpv; human; infection; patients cache: cord-256930-bz80uxnx.txt plain text: cord-256930-bz80uxnx.txt item: #104 of 427 id: cord-257073-dm80bxnd author: Akmatov, Manas K. title: E-mail-based symptomatic surveillance combined with self-collection of nasal swabs: a new tool for acute respiratory infection epidemiology date: 2011-08-17 words: 3518 flesch: 42 summary: The non-responder survey allowed us to compare prospectively (participants) and retrospectively (non-responders) collected data on acute respiratory infection symptoms, and it revealed that the prospective approach resulted in a higher rate of detection of mild infections. key: cord-257073-dm80bxnd authors: Akmatov, Manas K.; Krebs, Stephan; Preusse, Matthias; Gatzemeier, Anja; Frischmann, Ursula; Schughart, Klaus; Pessler, Frank title: E-mail-based symptomatic surveillance combined with self-collection of nasal swabs: a new tool for acute respiratory infection epidemiology date: 2011-08-17 journal: Int J Infect Dis DOI: 10.1016/j.ijid.2011.07.005 sha: doc_id: 257073 cord_uid: dm80bxnd OBJECTIVE: We examined the feasibility of combining communication by e-mail and self-collection of nasal swabs for the prospective detection of acute respiratory infections in a non-medical setting. keywords: influenza; nasal; participants; self; study; swab; time cache: cord-257073-dm80bxnd.txt plain text: cord-257073-dm80bxnd.txt item: #105 of 427 id: cord-257171-kp2huia0 author: Brand, Kim H. title: Use of MMP‐8 and MMP‐9 to assess disease severity in children with viral lower respiratory tract infections date: 2012-07-18 words: 5357 flesch: 38 summary: These data indicate that expression levels of the MMP‐8 and MMP‐9 genes in both PBMCs and neutrophils are associated with viral lower respiratory tract infections disease severity. These observations justify future validation in independent prospective study cohorts of the usefulness of MMP‐8 and MMP‐9 as potential markers for disease severity in viral respiratory infections. keywords: children; concentrations; disease; expression; infections; mmp-8; pbmcs; plasma; rsv; severity cache: cord-257171-kp2huia0.txt plain text: cord-257171-kp2huia0.txt item: #106 of 427 id: cord-257220-fe2sacjj author: Butler, J. E. title: Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic date: 2014-07-01 words: 19665 flesch: 41 summary: Porcine reproductive and respiratory syndrome Epidemiology of porcine reproductive and respiratory syndrome (PRRS): an overview Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332) in North America and experimental reproduction of the disease in gnotobiotic pigs Mystery swine disease in The Netherlands: the isolation of Lelystad virus Identification of a novel nidovirus associated with a neurological disease of the Australian brushtail possum (Trichosurus vulpecula) CD8 high cell In vivo discovery of immunotherapy targets in the tumour microenvironment Identification of cytotoxic T lymphocyte epitopes on swine viruses: multi-epitope design for universal T cell vaccine Gamma delta lymphocyte response to porcine reproductive and respiratory syndrome virus Efficacy of a modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in pigs naturally exposed to heterologous European (Italian cluster) field strain: clinical protection and cell-mediated immunity Hematological and immunological parameters of 4 1/2-month old pigs infected with PRRS virus Effects of different us isolates of porcine reproductive and respiratory syndrome virus (PRRSV) on blood and bone marrow parameters of experimentally infected pigs Experimental porcine reproductive and respiratory syndrome virus infection in one-, four-, and 10-week-old pigs Immunohistochemical identification of porcine reproductive and respiratory syndrome virus (PRRSV) antigen in the heart and lymphoid system of three-week-old colostrum-deprived pigs Comparison of the pathogenicity of two US porcine reproductive 138 and respiratory syndrome virus isolates with that of the Lelystad virus Attenuation of porcine reproductive and respiratory syndrome virus by molecular breeding of the virus envelope genes from genetically divergent strains Comparative pathogenicity of nine US porcine reproductive and respiratory syndrome virus (PRRSV) isolates in a five-week-old cesarean-derived, colostrum-deprived pig model Temporal and morphologic characterization of the distribution of porcine reproductive and respiratory syndrome virus (PRRSV) by in situ hybridization in pigs infected with isolates of PRRSV that differ in virulence Lymphodepletion and homeostatic proliferation: implications for transplantation Autologous regulation of naive T cell homeostasis within the T cell compartment A causal link between lymphopenia and autoimmunity Characterization of a porcine CD1-specific mAb that distinguishes CD4/CD8 double-positive thymic from peripheral T lymphocytes Antigen presentation in the thymus for positive selection and central tolerance induction The piglet as a model for B cell and immune system Gnotobiotic pigs derivation and rearing Antibody repertoire development in fetal and neonatal piglets. keywords: animals; antibodies; antibody; cells; development; disease; effect; fig; host; ifn; immune; immunity; infected; infection; isolator; piglets; pigs; porcine; protein; prrsv; response; strain; studies; swine; syndrome virus; system; t cells; type; viruses cache: cord-257220-fe2sacjj.txt plain text: cord-257220-fe2sacjj.txt item: #107 of 427 id: cord-257244-gryp0khc author: Edwards, M. R. title: The potential of anti‐infectives and immunomodulators as therapies for asthma and asthma exacerbations date: 2017-08-10 words: 5758 flesch: 25 summary: Despite these important associations, the use of antiinfectives (antibiotics, antivirals, antifungals, vaccines) that specifically target known pathogens, or drugs that are based on or exploit microbe-host receptor interactions (toll-like receptor agonists, bacterial lysates) or are immunomodulators (vitamin D), and/or may work in part by altering our associated microbiology (probiotics) are, with the exception of severe asthma, seldom considered in asthma treatment, prevention and guidelines. Evidence to date suggested that modulation of the gut microbiome may represent an interesting therapeutic or preventative opportunity for the prevention of allergic asthma and AE, whilst clinical trials do not confirm initial enthusiastic expectations. keywords: antibiotics; asthma; childhood; children; disease; influenza; risk; studies; study; treatment; trial; use; virus cache: cord-257244-gryp0khc.txt plain text: cord-257244-gryp0khc.txt item: #108 of 427 id: cord-257299-z9u12yqb author: Mansi, N. title: Ear, nose and throat manifestation of viral systemic infections in pediatric patients date: 2009-12-31 words: 5785 flesch: 39 summary: Treatment and prevention Utility of DNA microarrays for detection of viruses in acute respiratory tract infections in children Premorbid factors and outcome associated with respiratory virus infections in a pediatric intensive care unit. Premorbid factors and outcome associated with respiratory virus infections in a pediatric intensive care unit Inner ear and facial nerve complications of acute otitis media with focus on bacteriology and virology Malattie delle tonsille palatine e loro trattamento Upper respiratory virus detection without parent-reported illness in children is virus-specific Le basi patogenetiche delle infezioni respiratorie ricorrenti. keywords: acute; cases; children; complications; days; deafness; ebv; illness; infection; papillomatosis; period; treatment; virus cache: cord-257299-z9u12yqb.txt plain text: cord-257299-z9u12yqb.txt item: #109 of 427 id: cord-257656-z7zx46gd author: Ljubin-Sternak, Sunčanica title: The Emerging Role of Rhinoviruses in Lower Respiratory Tract Infections in Children – Clinical and Molecular Epidemiological Study From Croatia, 2017–2019 date: 2019-12-03 words: 4813 flesch: 40 summary: Therefore, we investigated the rhinovirus (RV) infection prevalence over a 2-year period, compared it with prevalence patterns of other common respiratory viruses, and explored clinical and molecular epidemiology of RV infections among 590 children hospitalized with acute respiratory infection in north-western and central parts of Croatia. Therefore, we investigated the rhinovirus (RV) infection prevalence over a 2-year period, compared it with prevalence patterns of other common respiratory viruses, and explored clinical and molecular epidemiology of RV infections among 590 children hospitalized with acute respiratory infection in north-western and central parts of Croatia. keywords: children; et al; human; infection; rhinovirus; species; strains; study cache: cord-257656-z7zx46gd.txt plain text: cord-257656-z7zx46gd.txt item: #110 of 427 id: cord-257805-pcp3qgn0 author: Mehta, Harsh title: Novel coronavirus-related acute respiratory distress syndrome in a patient with twin pregnancy: A case report date: 2020-05-16 words: 2227 flesch: 46 summary: In the data available in pregnant patients from the previous coronavirus outbreaks, no vertical transmission was reported [4] . During her hospital stay, she developed progressively worsening respiratory failure, initially requiring non-invasive ventilation, and subsequently progressed to acute respiratory distress syndrome requiring mechanical ventilation. keywords: case; coronavirus; covid-19; manuscript; respiratory cache: cord-257805-pcp3qgn0.txt plain text: cord-257805-pcp3qgn0.txt item: #111 of 427 id: cord-258139-x4js9vqe author: Callan, Robert J title: Biosecurity and bovine respiratory disease date: 2005-03-04 words: 7692 flesch: 34 summary: This problem has an infectious origin, and it is by far the most frequently occurring form of cattle respiratory disease. In general, nasal shedding of viral respiratory pathogens is significantly reduced by 14 days after infection but may persist longer in individual animals, which suggests that quarantine for approximately 14 to 21 days should significantly reduce the exposure and transmission of these pathogens within an operation. keywords: airborne; animal; biosecurity; bovine; calf; calves; cattle; disease; exposure; management; pathogens; transmission; ventilation; virus cache: cord-258139-x4js9vqe.txt plain text: cord-258139-x4js9vqe.txt item: #112 of 427 id: cord-258336-zs04l3s0 author: Leotte, Jaqueline title: Impact and seasonality of human rhinovirus infection in hospitalized patients for two consecutive years date: 2017-06-30 words: 3257 flesch: 39 summary: Marcone et al. 10 reported a higher number of HRV infections in hospitalized children in Argentina when compared with pediatric outpatients with acute respiratory infection, demonstrating a scenario that contributed to the increased concern about HRV infection in the hospital setting. This research had some limitations: (i) it was a retrospective study and some medical records were incomplete; (ii) HRV species were not identified, which would have yielded important data since the genotypes reportedly have different virulence; (iii) this analysis was carried out only with hospitalized patients, which may have overestimated the impact of HRV infection; and (iv) it was not possible to evaluate the frequency of nosocomial HRV infection, data critical to guide preventive measures in the most affected settings. keywords: cases; hrv; infections; patients; study cache: cord-258336-zs04l3s0.txt plain text: cord-258336-zs04l3s0.txt item: #113 of 427 id: cord-258366-fu9b446y author: Couto, Carla R. title: Fighting Misconceptions to Improve Compliance with Influenza Vaccination among Health Care Workers: An Educational Project date: 2012-02-06 words: 3290 flesch: 44 summary: The compliance with influenza vaccination is poor among health care workers (HCWs) due to misconceptions about safety and effectiveness of influenza vaccine. We proposed an educational prospective study to demonstrate to HCWs that influenza vaccine is safe and that other respiratory viruses (RV) are the cause of respiratory symptoms in the months following influenza vaccination. keywords: events; hcws; influenza; study; symptoms; vaccination; vaccine cache: cord-258366-fu9b446y.txt plain text: cord-258366-fu9b446y.txt item: #114 of 427 id: cord-258386-aiwzgkq3 author: MCLAREN, Rodney A. title: Delivery For Respiratory Compromise Among Pregnant Women With COVID-19 date: 2020-05-23 words: 897 flesch: 40 summary: Among the non-intubated, four had an improvement in oxygenation within two hours postpartum; two required less respiratory support, and two were taken completely off respiratory support. While we saw no harm, we 60 cannot be certain that delivery per se caused the improvement we saw, or whether a similar 61 outcome could have been achieved with ongoing respiratory support (although one of three 62 patients managed conservatively, remained on respiratory support for three weeks). keywords: delivery; support cache: cord-258386-aiwzgkq3.txt plain text: cord-258386-aiwzgkq3.txt item: #115 of 427 id: cord-259422-5ex12eun author: Graat, Judith M title: A prospective, community-based study on virologic assessment among elderly people with and without symptoms of acute respiratory infection date: 2003-12-11 words: 3903 flesch: 38 summary: key: cord-259422-5ex12eun authors: Graat, Judith M; Schouten, Evert G; Heijnen, Marie-Louise A; Kok, Frans J; Pallast, Esther G.M; de Greeff, Sabine C; Dorigo-Zetsma, J.Wendelien title: A prospective, community-based study on virologic assessment among elderly people with and without symptoms of acute respiratory infection date: 2003-12-11 journal: J Clin Epidemiol DOI: 10.1016/s0895-4356(03)00171-9 sha: doc_id: 259422 cord_uid: 5ex12eun BACKGROUND AND OBJECTIVE: Community-based elderly studies concerning microbiology of acute respiratory infections are scarce. In a 1-year community-based study, we prospectively investigated the possible virologic cause of acute respiratory infections in 107 symptomatic case episodes and 91 symptom-free control periods. keywords: acute; case; controls; infection; persons; study; symptoms cache: cord-259422-5ex12eun.txt plain text: cord-259422-5ex12eun.txt item: #116 of 427 id: cord-259927-xh9cw9ao author: Papadopoulos, Nikolaos G. title: Promising approaches for the treatment and prevention of viral respiratory illnesses date: 2017-07-21 words: 7351 flesch: 24 summary: A viruses Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies Layer-by-layer nanoparticle vaccines carrying the G protein CX3C motif protect against RSV infection and disease Eleven years of Inflexal V-a virosomal adjuvanted influenza vaccine Human papillomavirus and HPV vaccines: a review AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial M2e-based universal influenza A vaccine Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development Comparison of a novel microcrystalline tyrosine adjuvant with aluminium hydroxide for enhancing vaccination against seasonal influenza Matrix M H5N1 vaccine induces cross-H5 clade humoral immune responses in a randomized clinical trial and provides protection from highly pathogenic influenza challenge in ferrets Safety and immunogenicity of a recombinant M2e-flagellin influenza vaccine (STF2.4xM2e) in healthy adults Chitosan-a versatile semi-synthetic polymer in biomedical applications Genetic immunization is a simple method for eliciting an immune response Development of an intradermal DNA vaccine delivery strategy to achieve single-dose immunity against respiratory syncytial virus Modified mRNA vaccines protect against Zika virus infection DNA and RNA-based vaccines: principles, progress and prospects Replicon RNA viral vectors as vaccines Transforming growth factor-beta promotes rhinovirus replication in bronchial epithelial cells by suppressing the innate immune response Efficacy and safety of high-dose influenza vaccine in elderly adults: a systematic review and meta-analysis Effectiveness of MF59-adjuvanted seasonal influenza vaccine in the elderly: a systematic review and meta-analysis A systematic review and meta-analysis of cross-reactivity of antibodies induced by oil-in-water emulsion adjuvanted influenza H5N1 virus monovalent vaccines Preclinical pharmacokinetics of MHAA4549A, a human monoclonal antibody to influenza A virus, and the prediction of its efficacious clinical dose for the treatment of patients hospitalized with influenza A Efficacy and safety of treatment with an anti-m2e monoclonal antibody in experimental human influenza Safety and upper respiratory pharmacokinetics of the hemagglutinin stalk-binding antibody VIS410 support treatment and prophylaxis based on population modeling of seasonal influenza A outbreaks Priming by a novel universal influenza vaccine (Multimeric-001)-a gateway for improving immune response in the elderly population A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants Safety and immunogenicity of a Sf9 insect cell-derived respiratory syncytial virus fusion protein nanoparticle vaccine Immunogenicity and safety of a respiratory syncytial virus fusion protein (RSV F) nanoparticle vaccine in older adults Evaluation of the immunogenicity and safety of different doses and formulations of a broad spectrum influenza vaccine (FLU-v) developed by SEEK: study protocol for a single-center, randomized, double-blind and placebo-controlled clinical phase IIb trial Caparr os-Wanderley W. Synthetic Influenza vaccine (FLU-v) stimulates cell mediated immunity in a double-blind, randomised, placebo-controlled phase I trial A synthetic influenza virus vaccine induces a cellular immune response that correlates with reduction in symptomatology and virus shedding in a randomized phase Ib live-virus challenge in humans A T cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP1M1 in adults aged over 50 years A Phase IIA study to assess the safety and efficacy of a new influenza candidate vaccine MVA-NP1M1 in healthy adults-Flu002 Clinical Study Report Evaluating the immunogenicity and safety of a BiondVax-developed universal influenza vaccine (Multimeric-001) either as a standalone vaccine or as a primer to H5N1 influenza vaccine Back to the future: immunization with M-001 prior to trivalent influenza vaccine in 2011/12 enhanced protective immune responses against 2014/15 epidemic strain Safety and immunogenicity of multimeric-001-a novel universal influenza vaccine Implication of respiratory syncytial virus (RSV) F transgene sequence heterogeneity observed in Phase 1 evaluation of MEDI-534, a live attenuated parainfluenza type 3 vectored RSV vaccine Phase-I study MEDI-534, of a live, attenuated intranasal vaccine against respiratory syncytial virus and parainfluenza-3 virus in seropositive children A randomized, blinded, controlled, dose-ranging study of a respiratory syncytial virus recombinant fusion (F) nanoparticle vaccine in healthy women of childbearing age Efficacy of motavizumab for the prevention of respiratory syncytial virus disease in healthy Native American infants: a phase 3 randomised double-blind placebo-controlled trial Motavizumab for prophylaxis of respiratory syncytial virus in high-risk children: a noninferiority trial Trivalency of a nanobody specific for the human respiratory syncytial virus fusion glycoprotein drastically enhances virus neutralization and impacts escape mutant selection Efficacy, safety, and pharmacokinetics of a new 10% liquid intravenous immunoglobulin containing high titer neutralizing antibody to RSV and other respiratory viruses in subjects with primary immunodeficiency disease Treatment with novel RSV Ig RI-002 controls viral replication and reduces pulmonary damage in immunocompromised Sigmodon hispidus Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection Highly conserved protective epitopes on influenza B viruses Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A viruses Tackling influenza with broadly neutralizing antibodies Influenza virus vaccine based on the conserved hemagglutinin stalk domain Chimeric hemagglutinin influenza virus vaccine constructs elicit broadly protective stalk-specific antibodies Chimeric hemagglutinin constructs induce broad protection against influenza B virus challenge in the mouse model Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus Influenza vaccine research funded by the European Commission FP7-Health-2013-Innovation-1 project Antibodies to watch in 2017 Protective efficacy and immunogenicity of an adenoviral vector vaccine encoding the codon-optimized F protein of respiratory syncytial virus Immunogenicity of RSV F DNA vaccine in BALB/c Mice RSV fusion (F) protein DNA vaccine provides partial protection against viral infection Chimeric virus-like particles containing a conserved region of the G protein in combination with a single peptide of the M2 protein confer protection against respiratory syncytial virus infection Baculovirus-expressed virus-like particle vaccine in combination with DNA encoding the fusion protein confers protection against respiratory syncytial virus Co-immunization with virus-like particle and DNA vaccines induces protection against respiratory syncytial virus infection and bronchiolitis Respiratory syncytial virus: infection, detection, and new options for prevention and treatment Immunogenicity and efficacy of codon optimized DNA vaccines encoding the F-protein of respiratory syncytial virus Mucosal vaccines against respiratory syncytial virus Prevention of colds by vaccination against a rhinovirus: a report by the scientific committee on common cold vaccines Challenges in developing a cross-serotype rhinovirus vaccine Misdirected antibody responses against an N-terminal epitope on human rhinovirus VP1 as explanation for recurrent RV infections Wide-scale prevention through immunization appears to be within reach for respiratory syncytial virus and promising for influenza virus, whereas additional effort is needed in regard to rhinovirus, as well as other respiratory tract viruses. keywords: antiviral; asthma; human; ifv; immune; infection; influenza; novel; patients; prevention; rhinovirus; rna; rsv; safety; tract; treatment; trial; vaccine; virus; viruses cache: cord-259927-xh9cw9ao.txt plain text: cord-259927-xh9cw9ao.txt item: #117 of 427 id: cord-259997-8f8di4eu author: Botti, Chiara title: Characterization of respiratory infection viruses in hospitalized children from Naples province in Southern Italy date: 2018-04-13 words: 2848 flesch: 33 summary: Acute respiratory infections in children Aetiological role of common respiratory viruses in acute lower respiratory infections in children under five years: A systematic review and meta-analysis Chronic obstructive pulmonary disease Pulmonary health effects of air pollution Locally generated particulate pollution and respiratory symptoms in young children Using air pollution based community clusters to explore air pollution health effects in children Acute respiratory infections among under-five age group children at urban slums of Gulbarga City: A longitudinal study The World Health Report 1997-conquering suffering, enriching humanity Detection and characterization of respiratory viruses causing acute respiratory illness and asthma exacerbation in children during three different seasons FilmArray, an automated nested multiplex PCR system for multi-pathogen detection: Development and application to respiratory tract infection Respiratory virus detection in immunocompromised patients with FilmArray respiratory panel compared to conventional methods Multiplex PCR: Optimization and application in diagnostic virology BioFire filmarray respiratory panel for detection of enterovirus D68 Rhinovirus-associated hospitalizations in young children Clinical severity of rhinovirus/enterovirus compared to other respiratory viruses in children Diagnosis and treatment of rhinovirus respiratory infections Epidemiological, molecular, and clinical features of enterovirus respiratory infections in French children between 1999 and Manual of Clinical Microbiology Epidemiologic, experimental, and clinical links between respiratory syncytial virus infection and asthma Abrupt emergence of diverse species B adenoviruses at US military recruit training centers Division of Viral Diseases (DVD) Web site Prevention and control of seasonal influenza with vaccines; Recommendations of the Advisory Committee on Immunization Practices--United States Clinical disease in children associated with newly described coronavirus subtypes Epidemiology characteristics of respiratory viruses found in children and adults with respiratory tract infections in southern China Development of three multiplex RT-PCR assays for the detection of 12 respiratory RNA viruses Viral and atypical bacterial detection in acute respiratory infection in children under five years Detection of nine respiratory RNA viruses using three multiplex RT-PCR assays incorporating a novel RNA internal control transcript Air pollution and children's health The role of air pollution in asthma and other pediatric morbidities Air pollution, aeroallergens and admissions to pediatric emergency room for respiratory reasons in Turin, northwestern Italy Cancer prevalence in the city of Naples: Contribution of the GP database analyses to the cancer registries network Long-term associations of morbidity with air pollution: A Catalogue and Synthesis Urban air pollution and meteorological factors affect emergency department visits of elderly patients with chronic obstructive pulmonary disease in Taiwan key: cord-259997-8f8di4eu authors: Botti, Chiara; Micillo, Alberto; Ricci, Giuseppe; Russo, Adolfo; Denisco, Alberto; Cantile, Monica; Scognamiglio, Giosuè; De Rosa, Antonio; Botti, Gerardo title: Characterization of respiratory infection viruses in hospitalized children from Naples province in Southern Italy date: 2018-04-13 journal: Exp Ther Med DOI: 10.3892/etm.2018.6061 sha: doc_id: 259997 cord_uid: 8f8di4eu Most acute respiratory infections (ARIs) in children are due to viral etiology, and represent an important cause of mortality and morbidity in children <5 years old in developing countries. keywords: air; children; detection; infections; patients; respiratory; viruses cache: cord-259997-8f8di4eu.txt plain text: cord-259997-8f8di4eu.txt item: #118 of 427 id: cord-260225-bc1hr0fr author: Sirpilla, Olivia title: SARS-CoV-2-Encoded Proteome and Human Genetics: From Interaction-Based to Ribosomal Biology Impact on Disease and Risk Processes date: 2020-07-20 words: 8938 flesch: 32 summary: Superfamily 1 Helicase Has RNA and DNA Duplex-Unwinding Activities with 5′-to-3′ Polarity Structure-Function Analysis of Severe Acute Respiratory Syndrome Coronavirus RNA Cap Guanine-N7-Methyltransferase Functional Screen Reveals SARS Coronavirus Nonstructural Protein Nsp14 as a Novel Cap N7 Methyltransferase Characterization of the Guanine-N7 Methyltransferase Activity of Coronavirus Nsp14 on Nucleotide GTP The Cellular RNA Helicase DDX1 Interacts with Coronavirus Nonstructural Protein 14 and Enhances Viral Replication Crystal Structure and Mechanistic Determinants of SARS Coronavirus Nonstructural Protein 15 Define an Endoribonuclease Family Crystal Structure of a Monomeric Form of Severe Acute Respiratory Syndrome Coronavirus Endonuclease Nsp15 Suggests a Role for Hexamerization as an Allosteric Switch Structural and Biochemical Characterization of Endoribonuclease Nsp15 Encoded by Middle East Respiratory Syndrome Coronavirus Binding of the Methyl Donor S-Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2′-O-Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10 Coronavirus Nonstructural Protein 16 Is Group 2 Bat Coronaviruses A Two-Pronged Strategy to Suppress Host Protein Synthesis by SARS Coronavirus Nsp1 Protein Severe Acute Respiratory Syndrome Coronavirus Protein Nsp1 Is a Novel Eukaryotic Translation Inhibitor That Represses Multiple Steps of Translation Initiation Severe Acute Respiratory Syndrome Coronavirus Evades Antiviral Signaling: Role of Nsp1 and Rational Design of an Attenuated Strain Unique SARS-CoV Protein Nsp1: Bioinformatics, Biochemistry and Potential Effects on Virulence Coronavirus Nonstructural Protein 1: Common and Distinct Functions in the Regulation of Host and Viral Gene Expression Protein Structure and Sequence Reanalysis of 2019-NCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1 keywords: blast; cells; coronavirus; cov-2; decay; figure; human; immune; information; interaction; mrna; nonsense; nucleocapsid; protein; replication; respiratory; rna; sars; sequences; structure; syndrome cache: cord-260225-bc1hr0fr.txt plain text: cord-260225-bc1hr0fr.txt item: #119 of 427 id: cord-260238-2p209g2p author: Peiris, J S M title: Severe acute respiratory syndrome date: 2004-11-30 words: 6299 flesch: 30 summary: In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells HIV protease inhibitor nelfinavir inhibits replication of SARSassociated coronavirus Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs Interferon-β 1a and SARS coronavirus replication Severe acute respiratory syndrome-related coronavirus is inhibited by interferon-α The antiviral effect of interferon-β against SARS coronavirus is not mediated by MxA protein Old drugs as lead compounds for a new disease? HLA-B*4601 has been associated with severe SARS disease in Taiwan 94 but not Hong Kong 95 . keywords: associated; cells; coronavirus; cov; disease; health; human; individuals; infection; outbreak; protein; sars; spike; syndrome; transmission cache: cord-260238-2p209g2p.txt plain text: cord-260238-2p209g2p.txt item: #120 of 427 id: cord-260457-m1jbpo5l author: Allander, Tobias title: Human Bocavirus and Acute Wheezing in Children date: 2007-04-01 words: 3715 flesch: 46 summary: As part of a randomized, placebo-controlled clinical trial evaluating the efficacy of systemic corticosteroids for the treatment of acute expiratory wheezing in children, we performed extensive diagnostic evaluations for respiratory virus infection. We investigated the prevalence of HBoV and the genome HBoV load in the respiratory tract and blood specimens obtained from children who had been hospitalized for acute expiratory wheezing-the most common manifestation of lower respiratory tract infection in children-to investigate the association between HBoV infection and acute respiratory tract illness. keywords: acute; children; hbov; infection; samples; serum; virus; wheezing cache: cord-260457-m1jbpo5l.txt plain text: cord-260457-m1jbpo5l.txt item: #121 of 427 id: cord-260472-xvvfguht author: Papadopoulos, Nikolaos G. title: Antimicrobial strategies: An option to treat allergy? date: 2007-01-31 words: 5112 flesch: 20 summary: Effects on cell differentials and soluble markers in sputum in asthmatic subjects Rhinovirus replication in human macrophages induces NF-kappaB-dependent tumor necrosis factor alpha production Rhinovirus infection induces expression of its own receptor intercellular adhesion molecule 1 (ICAM-1) via increased NF-kappaB-mediated transcription Respiratory epithelial cell expression of vascular cell adhesion molecule-1 and its up-regulation by rhinovirus infection via NF-kappaB and GATA transcription factors Rhinovirus infection preferentially increases lower airway responsiveness in allergic subjects Duration of postviral airway hyperresponsiveness in children with asthma: effect of atopy The role of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and regulated on activation, normal T-cell expressed and secreted (RANTES) in the relationship between air pollution and asthma among children Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin-8 in nasal lavage in asthmatic subjects in vivo Rhinovirus inhalation causes long-lasting excessive airway narrowing in response to methacholine in asthmatic subjects in vivo Experimental rhinovirus 16 infection causes variable airway obstruction in subjects with atopic asthma Rhinovirus infection induces major histocompatibility complex class I and costimulatory molecule upregulation on respiratory epithelial cells Relationship of upper and lower airway cytokines to outcome of experimental rhinovirus infection Cytokines in asthma Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus Expression of costimulatory molecules in peripheral blood mononuclear cells of atopic asthmatic children during virus-induced asthma exacerbations Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects Nerve growth factor and nerve growth factor receptors in respiratory syncytial virus-infected lungs The role of neural inflammation in asthma and chronic obstructive pulmonary disease Neurotrophin overexpression in lower airways of infants with respiratory syncytial virus infection A defective type 1 response to rhinovirus in atopic asthma Atopic phenotype in children is associated with decreased virus-induced interferon-alpha release Impaired virus-induced interferon-alpha2 release in adult asthmatic patients IL-4 and interferon-gamma production in children with atopic disease Rhinovirus-induced interferon-gamma and airway responsiveness in asthma Antigen-nonspecific recruitment of Th2 cells to the lung as a mechanism for viral infection-induced allergic asthma Personal exposure to nitrogen dioxide (NO2) and the severity of virus-induced asthma in children Epidemiology of childhood asthma Are non-allergenic environmental factors important in asthma? Air pollution and infection in respiratory illness Nitrogen dioxide exposure: effects on airway and blood cells Synergism between rhinovirus infection and oxidant pollutant exposure enhances airway epithelial cell cytokine production Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study Presence of asthma risk factors and environmental exposures related to upper respiratory infection-triggered wheezing in middle school-age children Trial of roxithromycin in subjects with asthma and serological evidence of infection with Chlamydia pneumoniae Mycoplasma pneumoniae and Chlamydia pneumoniae in asthma: effect of clarithromycin Immunomodulatory activity and effectiveness of macrolides in chronic airway disease Clinical implications of the immunomodulatory effects of macrolides Chlamydia pneumoniae immunoglobulin A reactivation and airway inflammation in acute asthma Chlamydia pneumoniae infection and asthma Chlamydia and apoptosis: life and death decisions of an intracellular pathogen The development of asthma in children infected with Chlamydia pneumoniae is dependent on the modifying effect of mannose-binding lectin The effect of telithromycin in acute exacerbations of asthma Vaccines, vaccination, and vaccinology Prophylaxis with palivizumab against respiratory syncytial virus infection in infants with congenital heart diseasedwho should receive it? Immunopathology of RSV infection: prospects for developing vaccines without this complication Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern Adamantane resistance among influenza A viruses isolated early during the 2005e2006 influenza season in the United States Antiviral resistance in influenza viruseseimplications for management and pandemic response Neuraminidase inhibitor susceptibility network position statement: antiviral resistance in influenza A/H5N1 viruses The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design Comparison of the efficacy and safety of live attenuated cold-adapted influenza vaccine, trivalent, with trivalent inactivated influenza virus vaccine in children and adolescents with asthma Estimating efficacy of trivalent, cold-adapted, influenza virus vaccine (CAIV-T) against influenza A (H1N1) and B using surveillance cultures Safety and efficacy of trivalent inactivated influenza vaccine in young children: a summary for the new era of routine vaccination Direct and total effectiveness of the intranasal, live-attenuated, trivalent cold-adapted influenza virus vaccine against the 2000e2001 influenza A(H1N1) and B epidemic in healthy children Randomised placebo-controlled crossover trial on effect of inactivated influenza vaccine on pulmonary function in asthma Influenza vaccination in children with asthma: randomized double-blind placebo-controlled trial IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex Prevention of rhinovirus colds by human interferon alpha-2 from Escherichia coli Efficacy and tolerance of intranasally applied recombinant leukocyte A interferon in normal volunteers Intranasal interferon alpha 2 for prevention of rhinovirus infection and illness Intranasal interferon-alpha 2 prophylaxis of natural respiratory virus infection Intranasal interferonalpha 2b for seasonal prophylaxis of respiratory infection Interferon-beta ser as prophylaxis against experimental rhinovirus infection in volunteers Tolerance and efficacy of intranasal administration of recombinant beta serine interferon in healthy adults Ineffectiveness of recombinant interferon-beta serine nasal drops for prophylaxis of natural colds Role of deficient type III interferon-lambda production in asthma exacerbations Comparative susceptibility of respiratory viruses to recombinant interferons-alpha 2b and -beta Combined antiviral and antimediator treatment of rhinovirus colds Corticosteroids inhibit rhinovirus-induced intercellular adhesion molecule-1 up-regulation and promoter activation on respiratory epithelial cells Rhinovirus-induced airway inflammation in asthma: effect of treatment with inhaled corticosteroids before and during experimental infection A randomized controlled trial of glucocorticoid prophylaxis against experimental rhinovirus infection Doubling the dose of inhaled corticosteroid to prevent asthma exacerbations: randomised controlled trial Doubling the dose of budesonide versus maintenance treatment in asthma exacerbations Combination therapy: [124] can block pro-inflammatory mechanisms induced by virus infections in airway epithelial cells, although in vitro evidence has not been paralleled by convincing clinical data. keywords: airway; asthma; cells; children; chronic; exacerbations; infection; influenza; pneumoniae; rhinovirus; virus; viruses cache: cord-260472-xvvfguht.txt plain text: cord-260472-xvvfguht.txt item: #122 of 427 id: cord-260630-vvpzp73r author: Mandell, Lionel A. title: Etiologies of Acute Respiratory Tract Infections date: 2005-08-15 words: 2627 flesch: 48 summary: A case-control study of acute respiratory tract infection in general practice patients in The Netherlands Human metapneumovirus infection in adults with community-acquired pneumonia and exacerbation of chronic obstructive pulmonary disease Epidemiology of viral respiratory infections Coronavirus as a possible cause of severe acute respiratory syndrome A novel coronavirus associated with severe acute respiratory syndrome Virologic studies of acute respiratory disease in young adults. key: cord-260630-vvpzp73r authors: Mandell, Lionel A. title: Etiologies of Acute Respiratory Tract Infections date: 2005-08-15 journal: Clin Infect Dis DOI: 10.1086/432019 sha: doc_id: 260630 cord_uid: vvpzp73r nan In this issue of Clinical Infectious Diseases, there are 2 articles that provide us with some insight into the various etiologic agents that can cause acute respiratory tract infection (ARTI) in general practice patients in The Netherlands [1] and into the significance of the human metapneumovirus (hMPV) in patients with community-acquired pneumonia (CAP) and exacerbations of chronic obstructive pulmonary disease (COPD) in Quebec, Canada keywords: hmpv; infection; pathogens; patients; study; subjects cache: cord-260630-vvpzp73r.txt plain text: cord-260630-vvpzp73r.txt item: #123 of 427 id: cord-260750-utbuj5iz author: Dear, Jonathan D. title: Bacterial Pneumonia in Dogs and Cats date: 2013-11-21 words: 5230 flesch: 31 summary: Bacterial pneumonia remains one of the most common clinical diagnoses in dogs with either acute or chronic respiratory disease. New research suggests a complex relationship between viral respiratory diseases and development of bacterial pneumonia in dogs. keywords: airway; animals; aspiration; canine; cases; cats; disease; dogs; infection; pneumonia; signs cache: cord-260750-utbuj5iz.txt plain text: cord-260750-utbuj5iz.txt item: #124 of 427 id: cord-260871-dtn5t8ka author: Silva, Marcus Tulius T. title: SARS-CoV-2: Should We Be Concerned about the Nervous System? date: 2020-07-17 words: 4122 flesch: 36 summary: [39] Typically, SARS patients exhibited a triphasic pattern of disease, initially presenting with fever, a nonproductive cough, sore throat, and myalgia. A novel syndrome Self-reported olfactory and taste disorders in SARS-CoV-2 patients: a cross-sectional study Entry of coronavirus into primate CNS following peripheral infection SARS-associated coronavirus Coronavirus pathogenesis Renin-angiotensin-aldosterone system inhibitors in patients with COVID-19 Angiotensin-converting enzyme 2 in the brain: properties and future directions Epidemiological and clinical features of human coronavirus infections among different subsets of patients Epidemiology and clinical presentations of the four human coronaviruses 229E, HKU1, NL63, and OC43 detected over 3 years using a novel multiplex real-time PCR method Detection of the human coronavirus 229E, HKU1, NL63, and OC43 between 2010 and 2013 in Yamagata Two coronaviruses isolated from central nervous system tissue of two multiple sclerosis patients Murine hepatitis virus-a model for virus-induced CNS demyelination Human coronaviruses: viral and cellular factors involved in neuroinvasiveness and neuropathogenesis Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human Phylogeny of the SARS coronavirus The genome sequence of the SARSassociated coronavirus Characterization of a novel coronavirus associated with severe acute respiratory syndrome The severe acute respiratory syndrome Severe acute respiratory syndrome and critical care medicine: the Toronto experience Olfactory neuropathy in severe acute respiratory syndrome: report of a case Detection of SARS coronavirus RNA in the cerebrospinal fluid of a patient with severe acute respiratory syndrome Pathological findings of COVID-19 associated with acute respiratory distress syndrome Multiple organ infection and the pathogenesis of SARS Persistence of physical symptoms in and abnormal laboratory findings for survivors of severe acute respiratory syndrome Hypocortisolism in survivors of severe acute respiratory syndrome (SARS) Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice Coronavirus infection of rat dorsal root ganglia: ultrastructural characterization of viral replication, transfer, and the early response of satellite cells Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding A pneumonia outbreak associated with a new coronavirus of probable bat origin Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2 Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms The vagus nerve is one route of transneural invasion for intranasally inoculated influenza A virus in mice CNS innervation of vagal preganglionic neurons controlling peripheral airways: a transneuronal labeling study using pseudorabies virus Middle east respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4 Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study Detection of severe acute respiratory syndrome coronavirus in the brain: potential role of the chemokine mig in pathogenesis A first case of meningitis/encephalitis associated with SARS-coronavirus-2 COVID-19: consider cytokine storm syndromes and immunosuppression Guillain-barré syndrome associated with SARS-CoV-2 Miller fisher syndrome and polyneuritis cranialis in COVID-19 Pearls and oysters: facial nerve palsy as a neurological manifestation of COVID-19 infection Neurologic features in severe SARS-CoV-2 infection Large-vessel stroke as a presenting feature of COVID-19 in the young COVID-19 and its implications for thrombosis and anticoagulation D-dimer levels on admission to predict in-hospital mortality in patients with COVID-19 Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the central nervous system Neurologic alterations due to respiratory virus infections keywords: acute; coronavirus; cov; cov-2; covid-19; human; infection; patients; sars; syndrome cache: cord-260871-dtn5t8ka.txt plain text: cord-260871-dtn5t8ka.txt item: #125 of 427 id: cord-261025-y49su5uc author: Sampathkumar, Priya title: SARS: Epidemiology, Clinical Presentation, Management, and Infection Control Measures date: 2003-07-31 words: 3955 flesch: 46 summary: Specific instructions for collecting specimens from suspected SARS patients are available from the CDC. In all series of SARS cases described to date, therapy has involved broad-spectrum antibiotics, including a fluoroquinolone or macrolide. keywords: disease; fever; health; patients; sars; severe; symptoms; syndrome; transmission cache: cord-261025-y49su5uc.txt plain text: cord-261025-y49su5uc.txt item: #126 of 427 id: cord-261598-w2tyongu author: Babady, N Esther title: The FilmArray® respiratory panel: an automated, broadly multiplexed molecular test for the rapid and accurate detection of respiratory pathogens date: 2014-01-09 words: 6032 flesch: 36 summary: National ambulatory medical care survey: 2002 summary Etiology of community-acquired pneumonia in 254 hospitalized children Respiratory viral infections in children with leukemia Evaluation of multiple test methods for the detection of the novel 2009 influenza A (H1N1) during the New York City outbreak Early pulmonary complications after hematopoietic stem cell transplantation in pediatric patients: association with cytomegalovirus infection Nosocomial infections in patients with cancer Detection of respiratory viruses by molecular methods H1N1 influenza The challenge of respiratory virus infections in hematopoietic cell transplant recipients Respiratory virus infections after marrow transplant: the Fred Hutchinson Cancer Research Center experience Community respiratory virus infections in bone marrow transplant recipients: the M.D. Anderson Cancer Center experience Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major cancer center Viral infections in immunocompromised patients: what's new with respiratory viruses? Infectious disease hospitalizations among infants in the United States Management of respiratory infections in the elderly Parainfluenza virus infections in children with hematologic malignancies Symptomatic parainfluenza virus infections in children undergoing hematopoietic stem cell transplantation Changing epidemiology of respiratory viral infections in hematopoietic cell transplant recipients and solid organ transplant recipients Approach to common bacterial infections: respiratory viral panel fast for diagnosis of respiratory virus infections an automated nested multiplex PCR system for multi-pathogen detection: development and application to respiratory tract infection BioFire Diagnostics Inc. FilmArray Ò Operator's Manual RUO keywords: assays; detection; filmarray; filmarray rp; infections; influenza; panel; patients; rvp; sensitivity; viruses cache: cord-261598-w2tyongu.txt plain text: cord-261598-w2tyongu.txt item: #127 of 427 id: cord-261756-4lybl57r author: Dubert, Marie title: Late viral or bacterial respiratory infections in lung transplanted patients: impact on respiratory function date: 2020-02-24 words: 4190 flesch: 40 summary: The pathogenesis and management of influenza virus infection in organ transplant recipients Incidence and morbidity of human metapneumovirus and other community-acquired respiratory viruses in lung transplant recipients Rhinovirus and other respiratory viruses exert different effects on lung allograft function that are not mediated through acute rejection Respiratory virus infections and chronic lung allograft dysfunction: assessment of virology determinants Symptomatic respiratory virus infection and chronic lung allograft dysfunction Viral respiratory tract infection during the first postoperative year is a risk factor for chronic rejection after lung transplantation Respiratory viruses in lung transplant recipients: a critical review and pooled analysis of clinical studies The epidemiology of parainfluenza virus infection in lung transplant recipients Human metapneumovirus infection in lung transplant recipients: clinical presentation and epidemiology Upper and lower respiratory tract viral infections and acute graft rejection in lung transplant recipients Development of a respiratory virus panel test for detection of twenty human respiratory viruses by use of multiplex PCR and a fluid microbeadbased assay Incidence and outcomes of respiratory viral infections in lung transplant recipients: a prospective study Comparison of the Luminex xTAG Therefore, it seems important to assess the impact of respiratory viral infections on the graft function: to emphasize the prevention of viral infections for immunocompromised with more frequent sampling of patients including wide respiratory virus detection by molecular techniques and to strengthen spirometric controls after viral infections. keywords: bos; inclusion; infections; lung; months; patients; study; transplantation cache: cord-261756-4lybl57r.txt plain text: cord-261756-4lybl57r.txt item: #128 of 427 id: cord-261908-olcuq6tm author: Lai, Ka-Man title: Propagation of Respiratory Aerosols by the Vuvuzela date: 2011-05-23 words: 3984 flesch: 47 summary: We recommend that consideration is taken of their propensity to disseminate respiratory aerosols and that persons with respiratory infections be advised not to blow their vuvuzela in places where they risk infecting others. We hypothesised that vuvuzelas might facilitate the generation and dissemination of respiratory aerosols. keywords: aerosols; air; mean; particles; peak; shouting; vuvuzela cache: cord-261908-olcuq6tm.txt plain text: cord-261908-olcuq6tm.txt item: #129 of 427 id: cord-261941-xf1k5uj1 author: Stackhouse, Robin A. title: Severe acute respiratory syndrome and tuberculosis date: 2005-03-01 words: 5425 flesch: 52 summary: SARS patients should only be outside their room for required medical procedures. Many workers in the markets of southern China have tested positive for SARS-CoV antibody (40% wild animal traders, 20% wild animal butchers, 5% vegetable traders) without ever having evidence of SARS infection keywords: acute; contact; control; disease; health; infection; patient; room; sars; syndrome; treatment cache: cord-261941-xf1k5uj1.txt plain text: cord-261941-xf1k5uj1.txt item: #130 of 427 id: cord-262347-ejhz9rra author: Kappes, Matthew A. title: PRRSV structure, replication and recombination: Origin of phenotype and genotype diversity date: 2015-03-07 words: 10173 flesch: 21 summary: PRRSV replication closely ties three key features: rearrangement of host membranes to establish viral replication complexes (RC), synthesis and expression of gRNA, transcription of sgRNA for the efficient expression of structural proteins, at the same time as the unique ability to produce aberrant PRRSV sgRNAs known as heteroclites (Yuan et al., 2000 (Yuan et al., , 2004 . DI RNAs are generated through nonhomologous recombination between viral genomes resulting in random internal deletions but still encode the replication elements essential for generation of defective progeny virus including the genes encoding for the polymerase, essential replicase proteins, and capsid protein(s) (Yuan et al., 2000) . keywords: arterivirus; body; et al; genome; isolates; porcine; protein; prrsv; rdrp; recombination; region; replication; rna; sequence; sgrna; strains; syndrome; syndrome virus; synthesis; transcription; trs; type; virus cache: cord-262347-ejhz9rra.txt plain text: cord-262347-ejhz9rra.txt item: #131 of 427 id: cord-262366-cmjnb0al author: Gerna, Giuseppe title: Genetic variability of human coronavirus OC43‐, 229E‐, and NL63‐like strains and their association with lower respiratory tract infections of hospitalized infants and immunocompromised patients date: 2006-05-23 words: 5903 flesch: 43 summary: Frequency of and relationship between outbreaks of coronavirus infection Growth of human hepatoma cell lines with differentiated functions in chemically defined medium Coronavirus as a possible cause of severe acute respiratory syndrome Coronavirus 229E-related pneumonia in immunocompromised patients Rapid detection of human metapneumovirus strains in nasopharyngeal aspirates and shell vial cultures by monoclonal antibodies Identification of severe acute respiratory syndrome in Canada Monoclonal antibodies versus reverse transcription-PCR for detection of respiratory viruses in a patient population with respiratory tract infections admitted to hospital Detection and pathogenicity of human metapneumovirus respiratory infections in pediatric Italian patients during a winter-spring season Neonatal nosocomial respiratory infection with coronavirus: A prospective study in a neonatal intensive care unit Comparison of immunofluorescence with monoclonal antibodies and RT-PCR for the detection of human coronaviruses 229E and OC43 in cell culture Evidence of human coronavirus HKU1 and human bocavirus in Australian children Human respiratory coronavirus OC43: Genetic stability and neuroinvasion Early detection of acute rhinovirus infections by a rapid reverse transcription-PCR assay Cultivation of a novel type of commoncold virus in organ cultures Direct diagnosis of human respiratory coronaviruses 229E and OC43 by the polymerase chain reaction An outbreak of coronavirus OC43 respiratory infection in Normandy Human coronavirus NL63 Detection of the new human coronavirus HKU1: A report of 6 cases Detection of human coronavirus 229E in nasal specimens in large scale studies using an RT-PCR hybridisation assay Identification of a new human coronavirus Circulation of genetically distinct contemporary human coronavirus OC43 strains Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia Clinical and molecular epidemiological features of coronavirus HKU1-associated community-acquired pneumonia V. coronavirus 229E infections during six years of surveillance A new virus isolated from the human respiratory tract Mink lung cells and mixed mink lung and A549 cells for rapid detection of influenza virus and other respiratory viruses Seroepidemiologic survey of coronavirus (strain OC43) related infections in a children's population Detection of coronavirus 229E antibody by indirect hemagglutination Calf diarrhea coronavirus Mouse hepatitis virus strain JMH infects a human hepatocellular carcinoma cell line Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome Coronaviridae: The viruses and their replication Surveillance of community-acquired viral infections due to respiratory viruses in Rhone-Alpes (France) during winter 1994 to 1995 Occurrence and frequency of coronavirus infections in humans as determined by enzyme-linked imunosorbent assay Coronaviruses in the limelight Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease Seroepidemiologic studies of coronavirus infection in adults and children Coronavirus infection in acute lower respiratory tract disease of infants Diagnosis of human coronavirus infections by immunofluorescence: Method and application to respiratory disease in hospitalized children A novel pancoronavirus RT-PCR assay: Frequent detection of human coronavirus NL63 in children hospitalized with respiratory tract infections in Belgium The Tecumseh study of respiratory illness. keywords: et al; hcov; human; infections; like; oc43; patients; strains cache: cord-262366-cmjnb0al.txt plain text: cord-262366-cmjnb0al.txt item: #132 of 427 id: cord-262623-lmf2h6oc author: Light, R. Bruce title: Plagues in the ICU: A Brief History of Community-Acquired Epidemic and Endemic Transmissible Infections Leading to Intensive Care Admission date: 2009-01-31 words: 7820 flesch: 39 summary: Over the ensuing weeks several more cases of severe respiratory syndromes began to appear in the region, also undiagnosed. Such superantigens have since been implicated in a number of other disease syndromes, among them the streptococcal toxic shock syndrome (see below). keywords: care; cases; disease; failure; health; icu; infection; influenza; outbreak; pandemic; patients; pneumonia; shock; syndrome; virus cache: cord-262623-lmf2h6oc.txt plain text: cord-262623-lmf2h6oc.txt item: #133 of 427 id: cord-262673-j2ot35lt author: Ahmed-Hassan, Hanaa title: Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections date: 2020-08-18 words: 8607 flesch: 21 summary: Furthermore, respiratory epithelial cells and lung macrophages are capable of secreting a broad range of chemokines like IL-8, Macrophage inflammatory protein-1 Interestingly, previous studies found rapid and significant restoration of lymphocyte subsets including, NK cells, in peripheral blood in patients recovering from the initial stages of SARS infection (249) . keywords: acute; cells; coronavirus; cov; cov-2; covid-19; disease; human; ifn; infection; influenza; lung; macrophages; mers; patients; response; role; sars; syndrome; type cache: cord-262673-j2ot35lt.txt plain text: cord-262673-j2ot35lt.txt item: #134 of 427 id: cord-263141-n200x6z1 author: Zelaya, Hortensia title: Respiratory Antiviral Immunity and Immunobiotics: Beneficial Effects on Inflammation-Coagulation Interaction during Influenza Virus Infection date: 2016-12-23 words: 8207 flesch: 21 summary: These observations might be helpful to propose new Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase The amazing innate immune response to influenza A virus infection Critical role of constitutive type I interferon response in bronchial epithelial cell to influenza infection IFITM3 restricts the morbidity and mortality associated with influenza Molecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival Regulation of IFN-alpha/beta, MxA, 2ʹ,5ʹ-oligoadenylate synthetase, and HLA gene expression in influenza A-infected human lung epithelial cells Induction of innate immunity and its perturbation by influenza viruses The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1 The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA Inflammasome recognition of influenza virus is essential for adaptive immune responses NKp46 O-glycan sequences that are involved in the interaction with hemagglutinin type 1 of influenza virus Recognition of viral hemagglutinins by NKp44 but not by NKp30 Immune responses to influenza virus infection Exploiting mucosal immunity for antiviral vaccines Secretory IgA possesses intrinsic modulatory properties stimulating mucosal and systemic immune responses B cell responses to influenza infection and vaccination Regulating the adaptive immune response to respiratory virus infection Innate sensing of the gut microbiota: modulation of inflammatory and autoimmune diseases The commensal microbiota drives immune homeostasis Interactions between the microbiota and pathogenic bacteria in the gut Resurrecting the intestinal microbiota to combat antibiotic-resistant pathogens Antibiotics and the intestinal microbiome: individual responses, resilience of the ecosystem, and the susceptibility to infections Microbiota regulates immune defense against respiratory tract influenza Are similar immune mechanisms activated by the microbiota in high-risk populations (infants, elderly, immunocompromised hosts) in which respiratory viral infections are more frequent and severe? keywords: activation; cells; coagulation; ifv; immune; immunobiotics; infection; influenza; lung; mice; respiratory; response; studies; virus cache: cord-263141-n200x6z1.txt plain text: cord-263141-n200x6z1.txt item: #135 of 427 id: cord-263749-bbhh5xb1 author: Larenas-Linnemann, Désirée title: Enhancing innate immunity against virus in times of COVID-19: trying to untangle facts from fictions date: 2020-10-09 words: 4134 flesch: 0 summary: Results For each of these interventions we briefly comment on their definition, possible mechanisms and evidence of clinical efficacy or lack of it, especially focusing on respiratory tract infections, viral infections and eventually a reduced mortality in severe respiratory infections in the intensive care unit. With the use of Pidotimod there is a lower recurrence of respiratory tract infections as compared to conventional treatment and less use of antibiotics We encourage to wait for the results of the ongoing RCT before using BCG vaccination for the prevention of COVID-19 Hetero- The immune stimulation produced by heterologous vaccines enhances the response to other pathogens, different from the one in the vaccine and was associated with reduced all-cause infant mortality (e.g. measles vaccine, BCG). keywords: activity; acute; analysis; cells; covid-19; exercise; immunity; infections; review; sleep; tract; vitamin cache: cord-263749-bbhh5xb1.txt plain text: cord-263749-bbhh5xb1.txt item: #136 of 427 id: cord-263764-2ewz8ok4 author: Kutter, Jasmin S title: Transmission routes of respiratory viruses among humans date: 2018-01-17 words: 4392 flesch: 34 summary: Our observations underscore the urgent need for new knowledge on respiratory virus transmission routes and the implementation of this knowledge in infection control guidelines to advance intervention strategies for currently circulating and newly emerging viruses and to improve public health. Unfortunately, terms and definitions of respiratory transmission routes and isolation guidelines are not always used in a uniform way, leaving room for personal interpretation. keywords: aerosol; air; human; infection; influenza; outbreak; routes; sars; studies; transmission; viruses cache: cord-263764-2ewz8ok4.txt plain text: cord-263764-2ewz8ok4.txt item: #137 of 427 id: cord-263927-hnsyas9q author: Peci, Adriana title: Community‐acquired respiratory viruses and co‐infection among patients of Ontario sentinel practices, April 2009 to February 2010 date: 2012-08-09 words: 3211 flesch: 41 summary: Duration of symptoms significantly affects detection rate Frequent detection of viral coinfection in children hospitalized with acute respiratory tract infection using a real-time polymerase chain reaction Multipathogen infections in hospitalized children with acute respiratory infections Development of a respiratory virus panel test for detection of twenty human respiratory viruses by use of multiplex PCR and a fluid microbead-based assay Low mortality rates related to respiratory virus infections after bone marrow transplant Incidence of common respiratory viral infections related to climate factors in hospitalized children in Hong Kong Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology Prevalence of human respiratory viruses in adults with acute respiratory tract infections in Beijing Correlation of viral load of respiratory pathogens and co-infections with disease severity in children hospitalized for lower respiratory tract infection Impact of respiratory virus infections on persons with chronic underlying conditions Human metapneumovirus and respiratory syncytial virus in hospitalized Danish children with acute respiratory tract infection Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during spring-summer 2009: four observational studies from Canada Evidence from multiplex molecular assays for complex multipathogen interaction in acute respiratory infections Rhinovirus outbreaks in long-term care facilities Viruses in communityacquired pneumonia in children aged less than 3 years old; High rate of viral confection Correlation of pandemic (H1N1) 2009 viral load with disease severity and prolonged viral shedding in children Self-reported pH1N1 influenza vaccination coverage for Ontario Streptococcus pneumonia coinfection is correlated with the severity of H1N1 pandemic influenza Invasive group ⁄ ⁄ A (H1N1)v, RVS: The race for hivernal pandemics Respiratory virus infections among hospitalized patients with suspected influenza A H1N1 2009 virus during the first pandemic wave in Brazil Bacterial coinfections in lung tissue specimens from fatal cases of The association of newly identified respiratory viruses with lowers respiratory tract infections in Korean children Association of rhinovirus infection with increased disease severity in acute bronchiolitis Single versus dual respiratory virus infections in hospitalized infants: keywords: infection; influenza; patients; samples; single; viruses cache: cord-263927-hnsyas9q.txt plain text: cord-263927-hnsyas9q.txt item: #138 of 427 id: cord-264059-jf4j00bp author: Lee, Chien-Chang title: Combining Procalcitonin and Rapid Multiplex Respiratory Virus Testing for Antibiotic Stewardship in Older Adult Patients With Severe Acute Respiratory Infection date: 2019-11-30 words: 4621 flesch: 32 summary: The advent of sensitive point-of-care (POC) molecular detection methods has made rapid diagnosis of respiratory virus infections possible. Older adults are more vulnerable to respiratory virus infection. keywords: acute; antibiotics; infection; influenza; patients; pct; study; virus cache: cord-264059-jf4j00bp.txt plain text: cord-264059-jf4j00bp.txt item: #139 of 427 id: cord-264079-u0nkjexi author: Murphy, Dianne title: The use of gowns and masks to control respiratory illness in pediatric hospital personnel date: 1981-11-30 words: 2677 flesch: 51 summary: Bastin R: Maladies infectieuses Acquisition of parainfluenza 3 virus infection by hospitalized children Nosocomial respiratory syncytial virus infections Control of nosocomial respiratory syncytial viral infections Respiratory syncytial virus infection in adults The immunologic response to respiratory syncytial virus infection in infants Rapid virus diagnosis: Application of immunoftuorescence Clinical and immunological response of infants and children to administration of low temperature adapted respiratory syncytial virus Diagnostic procedures for viral & rickettsial infections Modes of spread of respiratory syncytial virus (RSV) Handto-hand transmission of rhinovirus colds The study took place in February and March of 1979, when RSV infections were widespread and influenza A/USSR virus was also present in the community. keywords: illness; infants; infections; personnel; rsv; study; virus cache: cord-264079-u0nkjexi.txt plain text: cord-264079-u0nkjexi.txt item: #140 of 427 id: cord-264255-q5izs39f author: Chieochansin, Thaweesak title: Human bocavirus (HBoV) in Thailand: Clinical manifestations in a hospitalized pediatric patient and molecular virus characterization date: 2007-12-31 words: 2679 flesch: 41 summary: Cloning of a human parvovirus by molecular screening of respiratory tract samples Complete coding sequence and phylogenetic analysis of human bocavirus (HBoV) Human bocavirus: prevalence and clinical spectrum at a children's hospital Detection of human bocavirus in Cannadian children in a 1 year study Frequent detection of human rhinoviruses, paramyxoviruses, coronaviruses, and bocavirus during acute respiratory tract infection Human bocavirus infection The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children Bocavirus infection in hospitalized children Human bocavirus in French children Human bocavirus infection among children Detection of human bocavirus in Japanese children with lower respiratory tract infection Epidermiology profile and clinical associations of human bocavirus and other human parvovirus Real-Time PCR assays for detection of bocavirus in human specimens Evidence of human coronavirus HKU1 and human bocavirus in Australian children Human bocavirus in hospitalized children Frequent detection of bocavirus DNA in German children with respiratory tract infections Human bocavirus and acute wheezing in children Human bocavirus: A novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand High prevalence of human bocavirus detected in young children with severe acute lower respiratory tract disease by use of a standard PCR protocol and a novel Real-Time PCR protocol Human bocavirus in Italian patients with respiratory diseases Human bocavirus in febrile children, the Netherlands Human bocavirus in Iranian children with acute respiratory infections Human bocavirus infection, people's republic of China Human bocavirus DNA detected by quantitative real-time PCR in two children hospitalized for lower respiratory tract infection Human bocavirus infection in young children in the United States: molecular epidemiological profile and clinical characteristics of a newly emerging respiratory virus Detection of bocavirus DNA in nasopharyngeal aspirates of a child with bronchiolitis Evaluation of PCR testing of ethanol-fixed nasal swab specimens as an augmented surveillance strategy for influenza virus and adenovirus identification Detection and characterization of new influenza B virus variants in 2002 Plasma endothelin-1 in infants and young children with acute bronchiolitis and viral pneumonia The incidence of HBoV infection in pediatric patients amounted to 6.62% with 40% co-infected with other respiratory viruses. keywords: bocavirus; children; gene; hbov; human; infection; samples; tract cache: cord-264255-q5izs39f.txt plain text: cord-264255-q5izs39f.txt item: #141 of 427 id: cord-265054-52eqdlef author: Schaller, Matthew title: Respiratory viral infections drive chemokine expression and exacerbate the asthmatic response date: 2006-08-03 words: 5422 flesch: 32 summary: By this same theory, it has been demonstrated that chemokine levels produced during respiratory syncytial virus infection determine host responses to later immune stimuli in the lung, with the potential to augment the asthmatic response. A virus infection inhibits the efficient recruitment of Th2 cells into the airways and the development of airway eosinophilia Respiratory syncytial virus infection in elderly and high-risk adults The relationship between respiratory syncytial virus infections and the development of wheezing and asthma in children Respiratory viruses and exacerbations of asthma in adults Macrophage inflammatory protein-1alpha and RANTES are present in nasal secretions during ongoing upper respiratory tract infection A comparison of epidemiologic and immunologic features of bronchiolitis caused by influenza virus and respiratory syncytial virus A comparison of cytokine responses in respiratory syncytial virus and influenza A infections in infants Interleukin-6, interleukin-8, interleukin-11, and interferon-gamma levels in nasopharyngeal aspirates from wheezing children with respiratory syncytial virus or influenza A virus infection Chemokines in nasal secretions of normal adults experimentally infected with respiratory syncytial virus Local and systemic cytokine responses during experimental human influenza A virus infection. keywords: allergen; cells; chemokines; infection; influenza; response; rsv; virus cache: cord-265054-52eqdlef.txt plain text: cord-265054-52eqdlef.txt item: #142 of 427 id: cord-265257-p9f0pl3y author: Masoud, Khaldoun title: Viral Etiology of Acute Respiratory Infections in Pediatric Patients in Lebanon date: 2019-11-01 words: 2944 flesch: 47 summary: Influenza Other Respir Viruses Viral coinfection in acute respiratory infection in Mexican children treated by the emergency service: A cross-sectional study Respiratory Viral Infections in Infants: Causes, Clinical Symptoms, Virology, and Immunology RATE AND INFLUENCE OF RESPIRATORY VIRUS CO-INFECTION ON PANDEMIC (H1N1) INFLUENZA DISEASE Dual Infection of Infants by Human Metapneumovirus and Human Respiratory Syncytial Virus Is Strongly Associated with Severe Bronchiolitis Single versus dual respiratory virus infections in hospitalized infants: impact on clinical course of disease and interferon-gamma response Human metapneumovirus infections cause similar symptoms and clinical severity as respiratory syncytial virus infections Viral and atypical bacterial detection in acute respiratory infection in children under five years Influenza Other Respir Viruses Use of antibiotics for adult upper respiratory infections in outpatient settings: A national ambulatory network study Excessive Antibiotic Use for Acute Respiratory Infections in the United States Viral Infections of the Lower Respiratory Tract: Old Viruses, New Viruses, and the Role of Diagnosis Simultaneous detection and high-throughput identification of a panel of RNA viruses causing respiratory tract infections Etiology, seasonality and clinical characterization of viral respiratory infections among hospitalized children in Beirut, Lebanon Viral and atypical bacterial aetiologies of infection in hospitalised patients admitted with clinical suspicion of influenza in Thailand, Vietnam and Indonesia. keywords: children; cvev; infections; patients; respiratory; study; viruses cache: cord-265257-p9f0pl3y.txt plain text: cord-265257-p9f0pl3y.txt item: #143 of 427 id: cord-265354-ajfjrnr9 author: Vu, D.‐L. title: Respiratory Viruses in Lung Transplant Recipients: A Critical Review and Pooled Analysis of Clinical Studies date: 2011-04-26 words: 3754 flesch: 31 summary: Clinical features and association with bronchiolitis obliterans syndrome The value of polymerase chain reaction for the diagnosis of viral respiratory tract infections in lung transplant recipients Influenza and parainfluenza respiratory viral infection requiring admission in adult lung transplant recipients Respiratory viruses and chronic rejection in lung transplant recipients Influenza virus infection in adult solid organ transplant recipients Indirect fluorescent antibody testing of nasopharyngeal swabs for influenza diagnosis in lung transplant recipients Detection of severe human Metapneumovirus infection by real-time polymerase chain reaction and histopathological assessment Human metapneumovirus infection in lung transplant recipients: The detection rate of respiratory viral infection ranged from 1.4% to 60%. keywords: infection; lung; rejection; studies; transplant; viruses cache: cord-265354-ajfjrnr9.txt plain text: cord-265354-ajfjrnr9.txt item: #144 of 427 id: cord-265380-2gs34xcw author: Leist, Sarah R. title: Genetically Engineering a Susceptible Mouse Model for MERS-CoV-Induced Acute Respiratory Distress Syndrome date: 2019-09-14 words: 6031 flesch: 46 summary: After infection mice are monitored daily for weight loss for the entire duration of the experiment. The WHO R&D Blueprint: 2018 review of emerging infectious diseases requiring urgent research and development efforts Comparative analysis of eleven healthcare-associated outbreaks of Middle East respiratory syndrome coronavirus (Mers-Cov) from Economic impact of the 2015 MERS outbreak on the Republic of Korea's tourism-related industries Costly lessons from the 2015 Middle East respiratory syndrome coronavirus outbreak in Korea Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission Middle East respiratory syndrome coronavirus transmission among health care workers: implication for infection control MERS transmission and risk factors: a systematic review High prevalence of MERS-CoV infection in camel workers in Saudi Arabia Reported direct and indirect contact with dromedary camels among laboratory-confirmed MERS-CoV cases Dromedary camels and the transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) Severe acute respiratory syndrome Modeling pathogenesis of emergent and pre-emergent human coronaviruses in mice Origin and evolution of pathogenic coronaviruses Jumping species-a mechanism for coronavirus persistence and survival Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection-clinicopathological and ultrastructural study Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates Middle East respiratory syndrome Viral load kinetics of MERS coronavirus infection The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody Prophylaxis with a Middle East respiratory syndrome coronavirus (MERS-CoV)-specific human monoclonal antibody protects rabbits from MERS-CoV infection Lack of Middle East respiratory syndrome coronavirus transmission in rabbits Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Pneumonia from human coronavirus in a macaque model Treatment with lopinavir/ritonavir or interferon-beta1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Infection with MERS-CoV causes lethal pneumonia in the common marmoset A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques 3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012 Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus Rapid generation of a mouse model for Middle East respiratory syndrome Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease Middle East Respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4 Multi-organ damage in human dipeptidyl peptidase 4 transgenic mice infected with Middle East respiratory syndrome-coronavirus Pre-and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice Adaptive evolution influences the infectious dose of MERS-CoV necessary to achieve severe respiratory disease Elevated human dipeptidyl peptidase 4 expression reduces the susceptibility of hDPP4 transgenic mice to Middle East respiratory syndrome coronavirus infection and disease CD8+ T cells and macrophages regulate pathogenesis in a mouse model of Middle East respiratory syndrome A human DPP4-Knockin Mouse's susceptibility to infection by authentic and pseudotyped MERS-CoV Acute respiratory infection in human dipeptidyl peptidase 4-transgenic mice infected with Middle East respiratory syndrome coronavirus Haagmans BL (2013) keywords: coronavirus; cov; disease; east; fig; hdpp4; human; infection; mers; mice; middle; model; mouse; syndrome cache: cord-265380-2gs34xcw.txt plain text: cord-265380-2gs34xcw.txt item: #145 of 427 id: cord-265445-bazcczdj author: Arias-Bravo, Guisselle title: Overnutrition in Infants Is Associated With High Level of Leptin, Viral Coinfection and Increased Severity of Respiratory Infections: A Cross-Sectional Study date: 2020-02-18 words: 4567 flesch: 42 summary: However, the empirical evidence needed to estimate the impact of overnutrition (including overweight and obese conditions) on the severity of viral respiratory infections in children is still lacking (10) . Tables 2, 3 present the results of the multiple Poisson regression by transforming beta coefficients from the regression into relative risk calculations, which allowed us to test and evaluate the hypothesis that overnutrition is associated with the severity of viral respiratory infections, by adjusting covariates. keywords: children; infants; infections; leptin; obese; obesity; overweight; severity; virus; viruses cache: cord-265445-bazcczdj.txt plain text: cord-265445-bazcczdj.txt item: #146 of 427 id: cord-265751-q1ecpfyg author: Shahani, Lokesh title: Antiviral therapy for respiratory viral infections in immunocompromised patients date: 2017-01-16 words: 10667 flesch: 27 summary: The challenge of respiratory virus infections in hematopoietic cell transplant recipients Airflow decline after myeloablative allogeneic hematopoietic cell transplantation: the role of community respiratory viruses Antiviral agents for the treatment and chemoprophylaxis of influenza -recommendations of the Advisory Committee on Immunization Practices (ACIP) The seasonal prevalence of influenza infections in immunocompromised patients, including solid-organ transplant and HSCT recipients, closely parallels the community-wide prevalence, with peaks from December to February, with Influenza B activity sometimes seen in April and May [19] . keywords: antiviral; cell; human; infections; influenza; oseltamivir; patients; piv; recipients; resistance; ribavirin; risk; rsv; therapy; transplant; treatment; use; virus; viruses cache: cord-265751-q1ecpfyg.txt plain text: cord-265751-q1ecpfyg.txt item: #147 of 427 id: cord-266260-t02jngq0 author: Ramshaw, Rebecca E. title: A database of geopositioned Middle East Respiratory Syndrome Coronavirus occurrences date: 2019-12-13 words: 7243 flesch: 30 summary: Vector Borne Zoonotic Dis Arabia: an index case investigation Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Stillbirth During Infection With Middle East Respiratory Syndrome Coronavirus Antibodies against MERS Coronavirus in Dromedary Camels MERS-CoV Antibodies in Humans, Africa No Serologic Evidence of Middle East Respiratory Syndrome Coronavirus Infection Among Camel Farmers Exposed to Highly Seropositive Camel Herds: A Household Linked Study Serological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County Occurrence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) across the Gulf Corporation Council countries: Four years update Emergence of MERS-CoV in the Middle East: origins, transmission, treatment, and perspectives Laboratory-confirmed case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in Malaysia: preparedness and response Dromedary camels in northern Mali have high seropositivity to MERS-CoV Middle East respiratory syndrome coronavirus (MERS-CoV) infections in two returning travellers in the Netherlands Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria Lack of serological evidence of Middle East respiratory syndrome coronavirus infection in virus exposed camel abattoir workers in Nigeria Asymptomatic MERS-CoV Infection in Humans Possibly Linked to Infected Dromedaries Imported from Oman to United Arab Emirates Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels The Middle East Respiratory Syndrome Coronavirus (MERS-COV) Zoonotic origin and transmission of Middle East respiratory syndrome coronavirus in the UAE Imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection from Oman to Thailand Serologic Evidence for MERS-CoV Infection in Dromedary Camels Contact tracing the first Middle East respiratory syndrome case in the Philippines Effectiveness of the Middle East respiratory syndrome-coronavirus protocol in enhancing the function of an Emergency Department in Qatar High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases Isolation of MERS coronavirus from a dromedary camel MERS-CoV Infection of Alpaca in a Region Where MERS-CoV is Endemic Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels Occupational Exposure to Dromedaries and Risk for MERS-CoV Infection Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Infection in Camel Workers in Qatar During 2013-2014: A Case-Control Study MERS-CoV outbreak in Jeddah-a link to health care facilities A case of long-term excretion and subclinical infection with Middle East respiratory syndrome coronavirus in a healthcare worker A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised with Acute Respiratory Disease Due to MERS Coronavirus or Other Causes A family cluster of Middle East Respiratory Syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case Acute Management and Long-Term Survival Among Subjects With Severe Middle East Respiratory Syndrome Coronavirus Pneumonia and ARDS Acute Middle East Respiratory Syndrome Coronavirus: Temporal Lung Changes Observed on the Chest Radiographs of 55 Patients Acute myocarditis associated with novel Middle east respiratory syndrome coronavirus An outbreak of Middle East Respiratory Syndrome (MERS) due to coronavirus in Al-Ahssa Region, Saudi Arabia Antibody Response and Disease Severity in Healthcare Worker MERS Survivors Brief Report: Family Cluster of Middle East Respiratory Syndrome Coronavirus Infections Characteristics and Outcomes of Middle East Respiratory Syndrome Coronavirus Patients Admitted to an Intensive Care Unit in Jeddah, Saudi Arabia Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a singlecenter experience in Saudi Arabia Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia Community case clusters of Middle East respiratory syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: a descriptive genomic study Description of a Hospital Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital in Saudi Arabia Descriptive epidemiology and characteristics of confirmed cases of Middle East respiratory syndrome coronavirus infection in the Makkah Region of Saudi Arabia Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Evidence for camel-to-human transmission of MERS coronavirus Exposures among MERS Case-Patients First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities Hospital outbreak of Middle East respiratory syndrome coronavirus Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Identified Transmission Dynamics of Middle East Respiratory Syndrome Coronavirus Infection During an Outbreak: Implications of an Overcrowded Emergency Department Impact of Middle East Respiratory Syndrome coronavirus (MERS-CoV) on pregnancy and perinatal outcome Lack of middle East respiratory syndrome coronavirus transmission from infected camels Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study Spread, circulation, and evolution of the Middle East A cluster analysis with implications for global management of suspected cases Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: Demographic, clinical and survival data Middle East respiratory syndrome coronavirus in children Middle East Respiratory Syndrome Coronavirus Infection During Pregnancy: A Report of 5 Cases From Saudi Arabia Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia Molecular Epidemiology of Hospital Outbreak of Middle East Respiratory Syndrome Notes from the Field: Nosocomial Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital-Riyadh, Saudi Arabia Outbreak of Middle East Respiratory Syndrome at Tertiary Care Hospital Patient characteristics infected with Middle East respiratory syndrome coronavirus infection in a tertiary hospital Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, crosssectional, serological study Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients Report of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection in Four Patients with Hematological Malignancies Treated at King Fahad Medical City Risk Factors for Middle East Respiratory Syndrome Coronavirus Infection among Healthcare Personnel Spontaneous intracranial hemorrhage in a patient with Middle East respiratory syndrome corona virus Successful recovery of MERS CoV pneumonia in a patient with acquired immunodeficiency syndrome: a case report Surveillance and Testing for Middle East Respiratory Syndrome Coronavirus, Saudi Arabia The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study The first case of the 2015 Korean Middle East Respiratory Syndrome outbreak Travel-related MERS-CoV cases: an assessment of exposures and risk factors in a group of Dutch travellers returning from the Kingdom of Saudi Arabia Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia Middle East respiratory syndrome coronavirus transmission among health care workers: Implication for infection control Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection -clinicopathological and ultrastructural study The calm before the storm: clinical observations of Middle East respiratory syndrome (MERS) patients The prevalence of Middle East respiratory Syndrome coronavirus (MERS-CoV) infection in livestock and temporal relation to locations and seasons Assessing the Detection of Middle East Respiratory Syndrome Coronavirus IgG in Suspected and Proven Cases of Middle East Respiratory Syndrome Coronavirus Infection Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia A cohort-study of patients suspected for MERS-CoV in a referral hospital in Saudi Arabia Conveyance Contact Investigation for Imported Middle East Respiratory Syndrome Cases Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses Outbreak of Middle East Respiratory Syndrome-Coronavirus Causes keywords: arabia; camels; case; coronavirus; cov; data; east; infection; mers; middle; middle east; outbreak; saudi; syndrome; syndrome coronavirus; transmission cache: cord-266260-t02jngq0.txt plain text: cord-266260-t02jngq0.txt item: #148 of 427 id: cord-266516-0ure8256 author: Lim, Tow Keang title: Pneumonia in the tropics date: 2017-08-01 words: 5308 flesch: 39 summary: Outbreak of leptospirosis among triathlon participants and community residents in Outbreak of human pneumonic plague with dog-to-human and possible human-to-human transmission -Colorado Infectious diseases following natural disasters: prevention and control measures Tsunami lung Disseminated aspergillosis associated with tsunami lung Epidemiology, co-infections, and outcomes of viral pneumonia in adults: an observational cohort study Viral pneumonia: epidemiological, clinical, pathophysiological and therapeutic aspects Viral infection in patients with severe pneumonia requiring intensive care unit admission Viral pneumonia in older adults The use of polymerase chain reaction amplification for the detection of viruses and bacteria in severe community-acquired pneumonia Respiratory syncytial virus infection: denominator-based studies in Indonesia Respiratory syncytial virus infection in tropical and developing countries Epidemiology and seasonality of respiratory tract virus infections in the tropics Epidemiology and seasonality of respiratory viral infections in hospitalized children in Kuala Lumpur, Malaysia: a retrospective study of 27 years Acute lower respiratory illnesses during the first three years of life: potential roles for various etiologic agents. 9 Examples of such diseases are influenza and leptospirosis. keywords: asia; cases; diagnosis; disease; human; infections; leptospirosis; patients; pneumonia; pulmonary; treatment; tropics cache: cord-266516-0ure8256.txt plain text: cord-266516-0ure8256.txt item: #149 of 427 id: cord-266716-pghnl980 author: Wang, Hai-Ming title: Isobavachalcone inhibits post-entry stages of the porcine reproductive and respiratory syndrome virus life cycle date: 2018-02-06 words: 3412 flesch: 43 summary: In this study, we observed that isobavachalcone (IBC), which was first isolated from Psoralea corylifolia, had potent anti-PRRSV activity in vitro. In the current study, for the first time, we observed that IBC has anti-PRRSV activity. keywords: cells; ibc; porcine; prrsv; replication; syndrome; virus cache: cord-266716-pghnl980.txt plain text: cord-266716-pghnl980.txt item: #150 of 427 id: cord-266822-ecq50ye2 author: Rath, Barbara title: Influenza and other respiratory viruses: standardizing disease severity in surveillance and clinical trials date: 2017-05-12 words: 10816 flesch: 31 summary: Experience during the recent influenza pandemic has shown that influenza disease severity appears rather unpredictable, especially in young patients. : findings from a multi-center, prospective study Human respiratory syncytial virus in children with acute respiratory tract infections in China Correlation between inflammatory mediators in the nasopharyngeal secretion and in the serum of children with lower respiratory tract infection caused by respiratory syncytial virus and disease severity Whole blood gene expression profiles to assess pathogenesis and disease severity in infants with respiratory syncytial virus infection Example of a study exploring the complex relationship between biomarkers and disease severity Innate immune dysfunction is associated with enhanced disease severity in infants with severe respiratory syncytial virus bronchiolitis Clinical course of communityacquired respiratory syncytial virus pneumonia in newborns hospitalized in neonatal intensive care unit Value of a risk scoring tool to predict respiratory syncytial virus disease severity and need for hospitalization in term infants FiO2 predicts outcome in infants with respiratory syncytial virus-induced acute respiratory distress syndrome Infants with severe respiratory syncytial virus needed less ventilator time with nasal continuous airways pressure then invasive mechanical ventilation Pulmonary matrix metalloproteinase-9 activity in mechanically ventilated children with respiratory syncytial virus Risk factors for respiratory syncytial virus bronchiolitis hospital admission in New Zealand Distribution and clinical impact of human respiratory syncytial virus genotypes in hospitalized children over 2 winter seasons Epidemiology of respiratory syncytial virus in children in Cyprus during three consecutive winter seasons (2010-2013): age distribution, seasonality and association between prevalent genotypes and disease severity Molecular epidemiology and disease severity of human respiratory syncytial virus in Vietnam Disease severity and viral load are correlated in infants with primary respiratory syncytial virus infection in the community Nasopharyngeal bacterial burden and antibiotics: influence on inflammatory markers and disease severity in infants with respiratory syncytial virus bronchiolitis Respiratory syncytial virus genomic load and disease severity among children hospitalized with bronchiolitis: multicenter cohort studies in the United States and Finland Five Study G. Epidemiological and clinical data of hospitalizations associated with respiratory syncytial virus infection in children under 5 years of age in Spain: FIVE multicenter study. keywords: care; children; clinical; data; disease; disease severity; human; infections; influenza; pandemic; patients; score; severity; severity score; study; surveillance; time; viral; virus; viruses cache: cord-266822-ecq50ye2.txt plain text: cord-266822-ecq50ye2.txt item: #151 of 427 id: cord-267003-k7eo2c26 author: Hendaus, Mohamed A title: Virus-induced secondary bacterial infection: a concise review date: 2015-08-24 words: 3471 flesch: 25 summary: For instance, TLR4 and TLR5 pathways are altered after influenza virus infection, resulting in decreased neutrophil attraction, thereby leading to increased attachment of S. pneumonia and P. aeruginosa to the airway epithelial cells. The human body is usually capable of eliminating respiratory viral infections with no sequelae; however, in some cases, viruses bypass the immune response of the airways, causing conceivable severe respiratory diseases. keywords: cells; children; infections; influenza; media; mxa; tract; virus; viruses cache: cord-267003-k7eo2c26.txt plain text: cord-267003-k7eo2c26.txt item: #152 of 427 id: cord-267274-3ygl3stc author: Britton, Philip N title: COVID-19 public health measures and respiratory syncytial virus date: 2020-09-18 words: 1039 flesch: 42 summary: Respiratory syncytial virus is one of the most burdensome viruses globally, and bronchiolitis (up to 80% of which is caused by respiratory syncytial virus) is a leading cause of hospital admission in young children. Respiratory syncytial virus is among the most common viruses that cause hospitalisation in children and has predictable winter seasonality. keywords: children; virus cache: cord-267274-3ygl3stc.txt plain text: cord-267274-3ygl3stc.txt item: #153 of 427 id: cord-267436-mivxm8oh author: Groneberg, David A title: Treatment and vaccines for severe acute respiratory syndrome date: 2005-03-10 words: 5918 flesch: 36 summary: The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen A cluster of cases of severe acute respiratory syndrome in Hong Kong A major outbreak of severe acute respiratory syndrome in Hong Kong Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study Description and clinical treatment of an early outbreak of severe acute respiratory syndrome (SARS) in Guangzhou, PR China Severe acute respiratory syndromerelated coronavirus is inhibited by interferon-alpha Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus Severe acute respiratory syndrome-associated coronavirus in lung tissue Common adverse events associated with the use of ribavirin for severe acute respiratory syndrome in Canada Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: a multicentre retrospective matched cohort study HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and beta-D-N4-hydroxycytidine Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus Novel peptide inhibitors of angiotensin-converting enzyme 2 Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors Cloaked similarity between HIV-1 and SARS-CoV suggests an anti-SARS strategy Inhibiting severe acute respiratory syndrome-associated coronavirus by small interfering RNA Modulation of HIV-1 replication by RNA interference Interference of hepatitis C virus RNA replication by short interfering RNAs Short interfering RNA-directed inhibition of hepatitis B virus replication Silencing SARS-CoV spike protein expression in cultured cells by RNA interference Inhibition of SARS-associated coronavirus infection and replication by RNA interference Effect of glycyrrhizin, an active component of licorice roots, on HIV replication in cultures of peripheral blood mononuclear cells from HIV-seropositive patients Long-term treatment of chronic hepatitis C with glycyrrhizin [stronger neo-minophagen C (SNMC)] for preventing liver cirrhosis and hepatocellular carcinoma Lamivudine and glycyrrhizin for treatment of chemotherapy-induced hepatitis B virus (HBV) hepatitis in a chronic HBV carrier with non-Hodgkin lymphoma Induction of inducible nitric oxide synthase and proinflammatory cytokines expression by o,pЈ-DDT in macrophages Inhibition of SARS-CoV infection in vitro by S-nitroso-Nacetylpenicillamine, a nitric oxide donor compound Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness Role of nitric oxide in chronic allergen-induced airway cell proliferation and inflammation Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide Small molecules targeting severe acute respiratory syndrome human coronavirus Pro/con clinical debate: steroids are a key component in the treatment of SARS Lung pathology of fatal severe acute respiratory syndrome Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area Severe acute respiratory syndrome (SARS) in Singapore: clinical features of index patient and initial contacts High-dose pulse versus nonpulse corticosteroid regimens in severe acute respiratory syndrome Fatal aspergillosis in a patient with SARS who was treated with corticosteroids SARS: prognosis, outcome and sequelae Avascular necrosis of bone in severe acute respiratory syndrome Role of interferons in the treatment of severe acute respiratory syndrome Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs Interferon-beta 1a and SARS coronavirus replication Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques How the SARS vaccine effort can learn from HIVspeeding towards the future, learning from the past Treatment of severe acute respiratory syndrome with convalescent plasma Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets Caution urged on SARS vaccines A review of feline infectious peritonitis virus: molecular biology, immunopathogenesis, clinical aspects, and vaccination Effects of a SARS-associated coronavirus vaccine in monkeys Mucosal immunisation of African green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS Severe acute respiratory syndrome coronavirus spike protein expressed by attenuated vaccinia virus protectively immunizes mice Nucleic acid vaccines: an overview A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice Generation and characterization of DNA vaccines targeting the nucleocapsid protein of severe acute respiratory syndrome coronavirus Induction of SARS-nucleoproteinspecific immune response by use of DNA vaccine SARS-one year later Seasonality of infectious diseases and severe acute respiratory syndrome-what we don't know can hurt us Clinical trials and novel pathogens: lessons learned from SARS Preparing to prevent severe acute respiratory syndrome and other respiratory infections Collateral damage: the unforeseen effects of emergency outbreak policies Support from the Deutsche Atemwegsliga and the German Research Foundation (DFG GR2014/2-1) to DAG is gratefully acknowledged. 13, 14 Evidence suggests that SARS coronavirus originated from SARS-like viruses in animals in the southern Chinese province of Guangdong; the most frequently implicated animal is the Himalayan palm civet, an animal found in food markets and eaten as a delicacy. keywords: coronavirus; outbreak; protein; replication; ribavirin; sars; severe; spike; steroids; syndrome; treatment; vaccines cache: cord-267436-mivxm8oh.txt plain text: cord-267436-mivxm8oh.txt item: #154 of 427 id: cord-267973-uvz7kavu author: Do, Lien Anh Ha title: Respiratory Syncytial Virus and Other Viral Infections among Children under Two Years Old in Southern Vietnam 2009-2010: Clinical Characteristics and Disease Severity date: 2016-08-08 words: 5924 flesch: 45 summary: RSV infections occurred at younger age than three other leading viral infections i.e rhinovirus (RV), metapneumovirus (MPV), parainfluenza virus (PIV-3) and were significantly more frequent in the first 6 months of life. Clinical severity score of RSV infection was significantly higher than PIV-3 but not for RV or MPV. keywords: cases; children; disease; infections; load; n(%; rsv; severity; study; virus cache: cord-267973-uvz7kavu.txt plain text: cord-267973-uvz7kavu.txt item: #155 of 427 id: cord-268038-9jjpc1a2 author: Boukhvalova, M title: Treatment with novel RSV Ig RI-002 controls viral replication and reduces pulmonary damage in immunocompromised Sigmodon hispidus date: 2015-09-14 words: 4359 flesch: 30 summary: In this work, we tested RI-002, a novel standardized Ig formulation containing a high level of RSV-neutralizing Ab, for its ability to control RSV infection in immunocompromised cotton rats Sigmodon hispidus. These results indicate the potential of RI-002 to improve outcome of RSV infection in immunocompromised subjects not only by controlling viral replication, but also by reducing damage to lung parenchyma and epithelial airway lining, but further studies are needed. keywords: animals; cotton; infection; rats; replication; ri-002; rsv; treatment; virus cache: cord-268038-9jjpc1a2.txt plain text: cord-268038-9jjpc1a2.txt item: #156 of 427 id: cord-268251-mcg1v24t author: Martins, Ronaldo Bragança title: Detection of respiratory viruses by real-time polymerase chain reaction in outpatients with acute respiratory infection date: 2014-09-17 words: 3162 flesch: 40 summary: Cloning of a human parvovirus by molecular screening of respiratory tract samples Respiratory tract viral infections Acute respiratory viral infections in ambulatory children of urban Northeast Brazil Viral potentiation of bacterial superinfection of the respiratory tract Clinical and financial benefits of rapid detection of respiratory viruses: an outcomes study Acute respiratory infection and influenza-like illness viral etiologies in Brazilian adults Viral and atypical bacterial detection in acute respiratory infection in children under five years Multiplex real-time PCR for detection of respiratory tract infections Prospective evaluation of a novel multiplex real-time PCR assay for detection of fifteen respiratory pathogens -duration of symptoms significantly affects detection rate WHO estimates of the causes of death in children Treatment of naturally acquired common colds with zinc: a structures review Severe lower respiratory tract infection in infants and toddlers from a non-affluent population: viral etiology and co-detection as risk factors Comparison of three multiplex PCR assays for the detection of respiratory viral infections: evaluation of xTAG respiratory virus panel fast assay, RespiFinder 19 assay and RespiFinder SMART 22 assay Respiratory syncytial virus infection: immune response, immunopathogenesis and treatment Real-time RT-PCR detection of 12 respiratory viral infections in four triplex reactions Serial viral infections in infants with recurrent respiratory illnesses A novel multiplex realtime RT-PCR assay with FRET hybridization probes for the detection and quantitation of 13 respiratory viruses The complication of coinfection Human bocavirus infections in hospitalized children and adults Human bocavirus -insights into a newly identified respiratory virus Development of a respiratory virus panel test for detection of twenty human respiratory viruses by use of multiplex PCR and a fluid microbead-based assay Detection of respiratory viruses by molecular methods Informe epidemiológico: influenza pandêmica (H1N1) New respiratory viruses of humans Hospitalization of influenza-like illness patients recommended by general practitioners in France between Rhinoviruses: important respiratory pathogens High rates of detection of respiratory viruses in tonsillar tissues from children with chronic adenotonsillar disease Laboratory diagnosis, epidemiology and clinical outcomes of pandemic influenza A and community respiratory viral infections in southern Brazil Comparison of fast-track diagnostics respiratory pathogens multiplex real-time RT-PCR assay with in-house singleplex assay for comprehensive detection of human respiratory viruses Clinical evaluation of multiplex real-time PCR panels for rapid detection of respiratory viral infections Osterhaus AD 2001. keywords: age; detection; multiplex; pcr; study; viruses cache: cord-268251-mcg1v24t.txt plain text: cord-268251-mcg1v24t.txt item: #157 of 427 id: cord-268324-86a0n0dc author: Charitos, Ioannis A title: Special features of SARS-CoV-2 in daily practice date: 2020-09-26 words: 6120 flesch: 38 summary: Current studies are investigating the relationship between different variables and the risk of death of COVID-19 patients hospitalized for pneumonia. COVID-19 patients are often very complex and require a multidisciplinary medical team which includes at least the following specialists: emergency doctor, pulmonologist, infectious disease specialist, critical care physician, and medical laboratory technician [72] keywords: cases; coronavirus; cov-2; covid-19; disease; health; infection; management; patients; pneumonia; risk; sars; symptoms; treatment; use; world cache: cord-268324-86a0n0dc.txt plain text: cord-268324-86a0n0dc.txt item: #158 of 427 id: cord-268388-kkhuzf3p author: Sharif-Yakan, Ahmad title: Emergence of MERS-CoV in the Middle East: Origins, Transmission, Treatment, and Perspectives date: 2014-12-04 words: 2508 flesch: 43 summary: A comparative serological study The emergence of the Middle East respiratory syndrome coronavirus (MERS-CoV) Middle east respiratory syndrome coronavirus: Epidemic potential or a storm in a teacup? Global Alert and Response: Middle East respiratory syndrome coronavirus (MERS-CoV) -update Middle east respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels, qatar Middle east respiratory syndrome coronavirus (MERS-CoV) in dromedary camels Middle east respiratory syndrome coronavirus in dromedary camels: An outbreak investigation Hospital outbreak of middle east respiratory syndrome coronavirus Interhuman transmissibility of middle east respiratory syndrome coronavirus: Estimation of pandemic risk Middle east respiratory syndrome coronavirus: Quantification of the extent of the epidemic, surveillance biases, and transmissibility Middle east respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques Interim infection control and prevention recommendations for hospitalized patients with MERS-CoV MERS Case Definition MERS clinical update from the IDSA Center for Disease Control and Prevention CDC Epidemiological, demographic, and clinical characteristics of 47 cases of middle east respiratory syndrome coronavirus disease from saudi arabia: A descriptive study Clinical features and viral diagnosis of two cases of infection with middle east respiratory syndrome coronavirus: A report of nosocomial transmission Family cluster of middle east respiratory syndrome coronavirus infections A patient with severe respiratory failure caused by novel human coronavirus A family cluster of middle east respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case Clinical features and virological analysis of a case of middle east respiratory syndrome coronavirus infection Epidemiological findings from a retrospective investigation WHO concludes MERS-CoV mission in Saudi Arabia MERS-CoV enigma deepens as reported cases surge Geographic distribution of MERS coronavirus among dromedary camels MERS coronaviruses in dromedary camels Middle East respiratory syndrome coronavirus (MERS-CoV) summary and literature update as of 20 Prevalence of MERS-CoV nasal carriage and compliance with the saudi health recommendations among pilgrims attending the 2013 hajj Lack of MERS coronavirus but prevalence of influenza virus in french pilgrims after 2013 hajj The receptor binding domain of MERS-CoV: The dawn of vaccine and treatment development Proteolytic processing, deubiquitinase and interferon antagonist activities of middle east respiratory syndrome coronavirus papain-like protease What are our pharmacotherapeutic options for MERS-CoV? International Severe Acute Respiratory & Emerging Infection Consortium (ISARIC)-Clinical Decision Making Tool for Treatment of MERS-CoV v.1.1 An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus Ribavirin and interferon therapy in patients infected with the middle east respiratory syndrome coronavirus: An observational study Repurposing of clinically developed drugs for treatment of middle east respiratory coronavirus infection The authors would like to acknowledge Sima L. Sharara for editing the manuscript. Emergence of a novel human coronavirus Middle East respiratory syndrome coronavirus (MERS-CoV) summary and literature update as of 26 Identification of a novel coronavirus in patients with severe acute respiratory syndrome Consensus document on the epidemiology of severe acute respiratory syndrome (SARS) Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Antibodies against MERS coronavirus in dromedary camels Replicative capacity of MERS coronavirus in livestock cell lines Middle east respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: keywords: coronavirus; cov; mers; middle; respiratory; syndrome cache: cord-268388-kkhuzf3p.txt plain text: cord-268388-kkhuzf3p.txt item: #159 of 427 id: cord-268490-e8jub01m author: Moscona, Anne title: CSI Microbiology: Emerging Pathogens and a Staged Strategy for Detection and Discovery date: 2007-12-15 words: 1070 flesch: 30 summary: In recent years, there has been substantial progress in applying molecular biologic advances to respiratory virus diagnosis [1] ; nonetheless, a major gap has been the lack of a costeffective, systematic way to identify the causes of respiratory diseases in populations. [2] and used in their study investigating the etiology of respiratory disease in hospitalized children, provides a paradigm for new detection strategies for early recognition and containment of a wide range of respiratory pathogens. keywords: disease; new cache: cord-268490-e8jub01m.txt plain text: cord-268490-e8jub01m.txt item: #160 of 427 id: cord-268729-n7slf5tx author: Wissinger, E L title: Manipulation of acute inflammatory lung disease date: 2008-05-07 words: 10114 flesch: 26 summary: A critical pathway for clearance of pathogens and infected lung epithelial cells is via NO and reactive oxygen and nitrogen species. A virus-induced infl ammatory cytokine production in airway epithelial cells IkappaB kinase is a critical regulator of chemokine expression and lung infl ammation in respiratory syncytial virus infection Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa Airway epithelium controls lung infl ammation and injury through the NF-kappa B pathway Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury Peroxisome proliferator-activated receptor-gamma is a new therapeutic target in sepsis and infl ammation Involvement of PPAR nuclear receptors in tissue injury and wound repair Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced REVIEW expression of intercellular adhesion molecule-1 in human lung epithelial cells The many paths to p38 mitogen-activated protein kinase activation in the immune system MAPK and heat shock protein 27 activation are associated with respiratory syncytial virus induction of human bronchial epithelial monolayer disruption Critical involvement of p38 MAP kinase in pertussis toxin-induced cytoskeletal reorganization and lung permeability Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice Chemoattractant receptor signaling and the control of lymphocyte migration Airway infl ammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases Tissue-and stimulus-dependent role of phosphatidylinositol 3-kinase isoforms for neutrophil recruitment induced by chemoattractants in vivo Regulation of phosphatidylinositol 3-kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury Blockade of infl ammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT Importance of phosphoinositide 3-kinase gamma in the host defense against pneumococcal infection Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses Evaluation of immunomodulators, interferons and known in vitro SARS-coV inhibitors for inhibition of SARS-coV replication in BALB/c mice Activity and regulation of alpha interferon in respiratory syncytial virus and human metapneumovirus experimental infections Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques Rhinovirus regulation of IL-1 receptor antagonist in vivo and in vitro : a potential mechanism of symptom resolution Interleukin-1 receptor antagonist transiently impairs antibacterial defense but not survival in murine pneumococcal pneumonia Interleukin 12 administration enhances Th1 activity but delays recovery from infl uenza keywords: acute; airway; cd8; cells; clearance; immune; immunity; infection; infl; inflammation; inflammatory; influenza; lung; lymphoid; mice; pulmonary; receptor; responses; tissue; uenza; virus cache: cord-268729-n7slf5tx.txt plain text: cord-268729-n7slf5tx.txt item: #161 of 427 id: cord-269437-0pvqvhqs author: Gastañaduy, Paul A. title: Update: Severe Respiratory Illness Associated with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) — Worldwide, 2012–2013 date: 2013-06-14 words: 1908 flesch: 40 summary: Severe respiratory illness associated with a novel coronavirus-Saudi Arabia and Qatar Novel coronavirus associated with severe respiratory disease: case definition and public health measures Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Middle East Respiratory Syndrome Coronavirus (MERS-CoV); announcement of the Coronavirus Study Group Global Alert and Response (GAR): novel coronavirus infection -update (Middle East respiratory syndrome coronavirus) Updated rapid risk assessment: severe respiratory disease associated with Middle East respiratory syndrome coronavirus (MERS-CoV) European Centre for Disease Prevention and Control. In addition, CDC recommends that clusters of severe acute respiratory illness be investigated and, if no obvious etiology is identified, local public health officials be notified and testing for MERS-CoV conducted, if indicated. keywords: cases; cov; mers; respiratory cache: cord-269437-0pvqvhqs.txt plain text: cord-269437-0pvqvhqs.txt item: #162 of 427 id: cord-269508-d82qjyyr author: Xu, Min title: Implementation of FilmArray Respiratory Viral Panel in a Core Laboratory Improves Testing Turnaround Time and Patient Care date: 2013-01-01 words: 3639 flesch: 44 summary: We performed FilmArray respiratory viral testing in a core laboratory at a regional children’s hospital that provides service 24 hours a day 7 days a week. We performed FilmArray respiratory viral testing in a core laboratory at a regional children's hospital that provides service 24 hours a day, 7 days a week. keywords: filmarray; hours; influenza; laboratory; patients; testing cache: cord-269508-d82qjyyr.txt plain text: cord-269508-d82qjyyr.txt item: #163 of 427 id: cord-270258-9vgpphiu author: Ko, Jae-Hoon title: Predictive factors for pneumonia development and progression to respiratory failure in MERS-CoV infected patients date: 2016-08-09 words: 3461 flesch: 38 summary: World Health Organization Case definition and management of patients with MERS coronavirus in Saudi Arabia MERS-CoV outbreak in Jeddah e a link to health care facilities On estimating the relation between blood group and disease Treatment outcomes for patients with Middle Eastern respiratory syndrome coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia Treatment strategies for Middle East respiratory syndrome coronavirus Treatment with lopinavir/ritonavir or interferon-beta1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Interim infection prevention and control recommendations for hospitalized patients with Middle East respiratory syndrome coronavirus (MERS-CoV), US CDC Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission Outcomes and prognostic factors in 267 patients with severe acute respiratory syndrome in Hong Kong White cell differential count and influenza A Thrombocytopenia in patients with severe acute respiratory syndrome (review) The clinical course of symptomatic MERS patients progressed serially: patients developed initial symptoms after a median 5-day incubation period (IQR 3.5e7.0), pneumonia after a median of 6 days from symptom onset (IQR 5.0e7.0), and respiratory failure after a median of 12 days from symptom onset (IQR 10.0e13.0). keywords: cov; development; factors; failure; mers; patients; pneumonia cache: cord-270258-9vgpphiu.txt plain text: cord-270258-9vgpphiu.txt item: #164 of 427 id: cord-270647-vn4kirrx author: Romero-Espinoza, Jose A. title: Virome and bacteriome characterization of children with pneumonia and asthma in Mexico City during winter seasons 2014 and 2015 date: 2018-02-15 words: 3518 flesch: 43 summary: Molecular detection of human rhinoviruses in respiratory samples: a comparison of Taqman probe-, SYBR green I-and BOXTObased real-time PCR assays Detection and Characterization of respiratory viruses causing Acute Respiratory Illness and Asthma Exacerbation in children during Three Different Season (2011-2014) in Mexico City. The role of respiratory viruses in the etiology of bacterial pneumonia: keywords: asthma; children; diseases; dna; et.al; pneumonia; reads; samples; tract; viruses cache: cord-270647-vn4kirrx.txt plain text: cord-270647-vn4kirrx.txt item: #165 of 427 id: cord-270947-6e5cw2q9 author: Huang, H.-S. title: Multiplex PCR system for the rapid diagnosis of respiratory virus infection: systematic review and meta-analysis date: 2017-12-05 words: 4034 flesch: 32 summary: Estimates of world-wide distribution of child deaths from acute respiratory infections Prevalence and correlation of infectious agents in hospitalized children with acute respiratory tract infections in Central China Community-acquired pneumonia requiring hospitalization: 5-year prospective study The effect of rapid respiratory viral diagnostic testing on antibiotic use in a children's hospital Cost-effective use of rapid diagnostic techniques in the treatment and prevention of viral respiratory infections Excessive antibiotic use for acute respiratory infections in the United States Detection of respiratory viruses by molecular methods Current approaches for diagnosis of influenza virus infections in humans Current best practices for respiratory virus testing Cost-effectiveness of rapid diagnosis of viral respiratory tract infections in pediatric patients Cost analysis of multiplex PCR testing for diagnosing respiratory virus infections Thermally multiplexed polymerase chain reaction Genotyping of respiratory syncytial virus (RSV) group A in Stockholm, Sweden, using PCR and two-dimensional melting curve analysis Nucleic acid amplificationebased diagnosis of respiratory virus infections Evaluation of multiple test methods for the detection of the novel 2009 influenza A (H1N1) during the New York City outbreak Emerging molecular assays for detection and characterization of respiratory viruses Development of a respiratory virus panel test for detection of twenty human respiratory viruses by use of multiplex PCR and a fluid microbead-based assay Evaluation of a multiplexed PCR assay for detection of respiratory viral pathogens in a public health laboratory setting RespiFinder: a new multiparameter test to differentially identify fifteen respiratory viruses Respiratory viruses in children admitted to hospital intensive care units: evaluating the CLART® Pneumovir DNA array Broad respiratory virus detection in infants hospitalized for bronchiolitis by use of a multiplex RT-PCR DNA microarray system Simultaneous detection and high-throughput identification of a panel of RNA viruses causing respiratory tract infections Rapid detection of respiratory tract viral infections and coinfections in patients with influenza-like illnesses by use of reverse transcriptionePCR DNA microarray systems The FilmArray® respiratory panel: an automated, broadly multiplexed molecular test for the rapid and accurate detection of respiratory pathogens Comparison of the FilmArray RP, Verigene RVþ, and Prodesse ProFLUþ/FASTþ multiplex platforms for detection of influenza viruses in clinical samples from the 2011e2012 influenza season in Belgium The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration Cochrane Diagnostic Test Accuracy Working Group. key: cord-270947-6e5cw2q9 authors: Huang, H.-S.; Tsai, C.-L.; Chang, J.; Hsu, T.-C.; Lin, S.; Lee, C.-C. title: Multiplex PCR system for the rapid diagnosis of respiratory virus infection: systematic review and meta-analysis date: 2017-12-05 journal: Clin Microbiol Infect DOI: 10.1016/j.cmi.2017.11.018 sha: doc_id: 270947 cord_uid: 6e5cw2q9 OBJECTIVES: keywords: analysis; detection; filmarray; influenza; prodesse; studies; study; verigene; virus; viruses cache: cord-270947-6e5cw2q9.txt plain text: cord-270947-6e5cw2q9.txt item: #166 of 427 id: cord-271172-y48dovux author: Potter, Christopher William title: Chapter 25 Respiratory tract viruses date: 1998-12-31 words: 8621 flesch: 32 summary: Infection is primarily of the epithelial cells of the oropharynx, and via the complement receptor CD21: virus infection from these cells spreads to P-lymphocytes where a few cells undergo lytic infection while the majority support a latent infection that leads to cell proliferation. In contrast, virus infections have been associated with ECG and EEG changes; some unconfirmed observations of virus antigen in brain and heart tissue have been published; and infection can be associated with viral encephalitis, particularly among children. keywords: cause; cells; children; days; disease; infection; influenza; patients; pneumonia; symptoms; tract; treatment; virus; viruses; years cache: cord-271172-y48dovux.txt plain text: cord-271172-y48dovux.txt item: #167 of 427 id: cord-271669-dkg6229j author: Han, Seung Beom title: Respiratory Viral Infections in Children and Adolescents with Hematological Malignancies date: 2019-01-01 words: 3775 flesch: 36 summary: Pediatr Blood Cancer Respiratory tract viral infections in bone marrow transplant patients Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major cancer center Respiratory virus infections after stem cell transplantation: a prospective study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation Detection of respiratory viruses with a multiplex polymerase chain reaction assay (MultiCode-PLx Respiratory Virus Panel) in patients with hematologic malignancies Respiratory viral infections and coinfections in children with cancer, fever and neutropenia: clinical outcome of infections caused by different respiratory viruses Prospective detection of respiratory pathogens in symptomatic children with cancer Acute respiratory viral infections in pediatric cancer patients undergoing chemotherapy Efficacy and safety of withholding antimicrobial treatment www.mjhid.org in children with cancer, fever and neutropenia, with a demonstrated viral respiratory infection: a randomized clinical trial Nasopharyngeal detection of respiratory viruses in febrile neutropenic children Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2018 update by the Infectious Diseases Society of America and the The impact of RSV, adenovirus, influenza, and parainfluenza infection in pediatric patients receiving stem cell transplant, solid organ transplant, or cancer chemotherapy Molecular characterization of strains of respiratory syncytial virus identified in a hematopoietic stem cell transplant outpatient unit over 2 years: community or nosocomial infection? Detection and control of a nosocomial respiratory syncytial virus outbreak in a stem cell transplantation unit: the role of palivizumab Control of an outbreak of human parainfluenza virus 3 in hematopoietic stem cell transplant recipients Impact of aerosolized ribavirin on mortality in 280 allogeneic haematopoietic stem cell transplant recipients with respiratory syncytial virus infections How I treat respiratory viral infections in the setting of intensive chemotherapy or hematopoietic cell transplantation Parainfluenza virus lower respiratory tract disease after hematopoietic cell transplant: viral detection in the lung predicts outcome Human rhinovirus detection in the lower respiratory tract of hematopoietic cell transplant recipients: association with mortality Parainfluenza virus infections in hematopoietic cell transplant recipients and hematologic malignancy patients: A systematic review Immunodeficiency scoring index to predict poor outcomes in hematopoietic cell transplant recipients with RSV infections Respiratory viral infections in immunocompetent and immunocompromised persons Mediterr J Hematol Infect Dis DOI: 10.4084/mjhid.2019.006 sha: doc_id: 271669 cord_uid: dkg6229j BACKGROUND: Despite the introduction of a polymerase chain reaction (PCR) test for the diagnosis of respiratory viral infection (RVI), guidance on the application of this test and the management of RVI in immunocompromised children is lacking. keywords: children; infection; patients; pcr; respiratory; rvi; study cache: cord-271669-dkg6229j.txt plain text: cord-271669-dkg6229j.txt item: #168 of 427 id: cord-271822-ohkki0ke author: Verma, Siddhartha title: Visualizing the effectiveness of face masks in obstructing respiratory jets date: 2020-06-01 words: 3258 flesch: 41 summary: Steps of fluid fragmentation leading to respiratory droplets The efficacy of standard surgical face masks: An investigation using tracer particles A quantitative assessment of the efficacy of surgical and N95 masks to filter influenza virus in patients with acute influenza infection Dispersion and exposure to a cough-generated aerosol in a simulated medical examination room Efficacy of face shields against cough aerosol droplets from a cough simulator Effectiveness of cough etiquette maneuvers in disrupting the chain of transmission of infectious respiratory diseases Respiratory virus shedding in exhaled breath and efficacy of face masks Assessment of a respiratory face mask for capturing air pollutants and pathogens including human influenza and rhinoviruses Simple respiratory protection-Evaluation of the filtration performance of cloth masks and common fabric materials against 20-1000 nm size particles Testing the efficacy of homemade masks: Would they protect in an influenza pandemic? Effectiveness of surgical and cotton masks in blocking SARS-CoV-2: A controlled comparison in 4 patients Aerosol filtration efficiency of common fabrics used in respiratory cloth masks Rational use of face masks in the COVID-19 pandemic Nonpharmaceutical measures for pandemic influenza in nonhealthcare settings-personal protective and environmental measures Flow dynamics and characterization of a cough Coughing frequency in patients with persistent cough: The masks help mitigate the risk of cross-infection via respiratory droplets; however, there are no specific guidelines on mask materials and designs that are most effective in minimizing droplet dispersal. keywords: air; cough; covid-19; droplets; face; masks; transmission cache: cord-271822-ohkki0ke.txt plain text: cord-271822-ohkki0ke.txt item: #169 of 427 id: cord-272143-6ej3eibd author: Benavides‐Nieto, Marta title: The role of respiratory viruses in children with humoral immunodeficiency on immunoglobulin replacement therapy date: 2018-12-21 words: 1878 flesch: 32 summary: 9, 10 In addition, there are several recent reports showing an increased susceptibility to viral respiratory infections in adults with CVID receiving IRT, 4-7 that can contribute to chronic and persistent pulmonary inflammation. 20,21 B-cell immune reconstitution and its consequences regarding viral respiratory infections have not been deeply investigated in these patients. keywords: children; immunodeficiency; infections; lung; patients; viruses cache: cord-272143-6ej3eibd.txt plain text: cord-272143-6ej3eibd.txt item: #170 of 427 id: cord-272179-wvw5mmy3 author: Calderaro, Adriana title: Human respiratory viruses, including SARS-CoV-2, circulating in the winter season 2019-2020 in Parma, Northern Italy date: 2020-10-02 words: 1098 flesch: 38 summary: Coronavirus Disease Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan First two months of the 2019 Coronavirus Disease (COVID-19) epidemic in China: real-time surveillance and evaluation with a second derivative model Epidemiology of human respiratory viruses in children with acute respiratory tract infection in a 3-year hospital-based survey in Northern Italy Mammalian Diaphanous-related formin-1 restricts early phases of influenza A/NWS/33 virus (H1N1) infection in LLC-MK2 cells by affecting cytoskeleton dynamics Risk factors for SARS-CoV-2 among patients in the Oxford Royal College of General Practitioners Research and Surveillance Centre primary care network: a cross-sectional study Coronaviruses and SARS-COV-2 Incidence and seasonality of respiratory viruses causing acute respiratory infections in the Northern United Arab Emirates Positive rate of RT-PCR detection of SARS-CoV-2 infection in 4880 cases from one hospital in Multiple versus single virus respiratory infections: viral load and clinical disease severity in hospitalized children Viruses as Sole Causative Agents of Severe Acute Respiratory Tract Infections in Children Mixed respiratory virus infections Cresce la popolazione del Parmense 2019-nCoV (Wuhan virus), a novel Coronavirus: human-to-human transmission, travel-related cases, and vaccine readiness Etiology and clinical outcomes of acute respiratory virus infection in hospitalized adults The outbreak of SARS-CoV-2 pneumonia calls vaccines Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology Respiratory virus surveillance in hospitalised pneumonia patients on the Thailand-Myanmar border World Health Organization. This study aimed to determine the prevalence of respiratory virus infections, including SARS-CoV-2, during December 2019 – March 2020, in a tertiary care hospital-based survey in Parma (Northern Italy). keywords: cov-2; infections; sars; viruses cache: cord-272179-wvw5mmy3.txt plain text: cord-272179-wvw5mmy3.txt item: #171 of 427 id: cord-272538-gclrtie7 author: Li, Xuechao title: Viral etiologies and epidemiology of patients with acute respiratory infections based on sentinel hospitals in Gansu Province, Northwest China, 2011‐2015 date: 2018-02-22 words: 2005 flesch: 36 summary: [33] [34] [35] This finding indicated that local pediatricians not only took priority over RSV infections but Global mortality, disability, and the contribution of risk factors: global burden of disease study Estimates of world-wide distribution of child deaths from acute respiratory infections Causes of deaths in children younger than 5 years in China Study on the viral etiology of acute respiratory tract infections in Shanghai area during 2009-2010 Prevalence of human respiratory viruses in adults with acute respiratory tract infections in Beijing Identification of viral and atypical bacterial pathogens in children hospitalized with acute respiratory infections in Hong Kong by multiplex PCR assays Viral Etiology of acute respiratory tract infections in hospitalized children and adults in Shandong Province Prevalence of respiratory viruses among children hospitalized from respiratory infections in Shenzhen, China Polymerase chain reaction for detection of adenoviruses in stool samples Bocavirus infection in hospitalized children Simultaneous detection of influenza A, B, and C viruses, respiratory syncytial virus, and adenoviruses in clinical samples by multiplex reverse transcription nested-PCR assay Simultaneous detection of fourteen respiratory viruses in clinical specimens by two multiplex reverse transcription nested-PCR assays Children with respiratory disease associated with metapneumovirus in Hong Kong Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia Viral etiology of acute respiratory infection in Gansu Province, China Viral etiologies of hospitalized acute lower respiratory infection patients in China Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory tract infections in 195 countries: a systematic analysis for the Global Burden of Disease Study Acute lower respiratory infections in developing countries Respiratory syncytial virus and other respiratory viral infections in older adults with moderate to severe influenza-like illness Viral infection in adults hospitalized with community-acquired pneumonia: prevalence, pathogens, and presentation Human coronaviruses: clinical features and phylogenetic analysis Molecular characterization of human respiratory syncytial virus in the Philippines Impact of respiratory syncytial virus infection as a cause of lower respiratory tract infection in children younger than 3 years of age in Japan Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis Respiratory syncytial virus hospitalization and mortality: systematic review and meta-analysis Detection and typing by molecular techniques of respiratory viruses in children hospitalized for acute respiratory infection in Rome, Italy Respiratory consequences of rhinovirus infection The common cold: a review of the literature The common cold Review of intranasal influenza vaccine Pre-clinical and clinical investigation of the safety of a novel adjuvant for intranasal immunization Seasonal influenza vaccine supply and target vaccinated population in China Viral and atypical bacterial detection in acute respiratory infection in children under five years Viral etiology of severe pneumonia among Kenyan young infants and children Acute viral lower respiratory tract infections in Cambodian children: clinical and epidemiologic characteristics Frequency and natural history of rhinovirus infections in adults during autumn Prevalence of human coronaviruses in adults with acute respiratory tract infections in Beijing Epidemiology and clinical presentations of the four human coronaviruses 229E, HKU1, NL63, and OC43 detected over 3 years using a novel multiplex real-time PCR method Viral etiologies and epidemiology of patients with acute respiratory infections based on sentinel hospitals in Gansu Province key: cord-272538-gclrtie7 authors: Li, Xuechao; Li, Juansheng; Meng, Lei; Zhu, Wanqi; Liu, Xinfeng; Yang, Mei; Yu, Deshan; Niu, Lixia; Shen, Xiping title: Viral etiologies and epidemiology of patients with acute respiratory infections based on sentinel hospitals in Gansu Province, Northwest China, 2011‐2015 date: 2018-02-22 journal: J Med Virol DOI: 10.1002/jmv.25040 sha: doc_id: 272538 cord_uid: gclrtie7 Understanding etiological role and epidemiological profile is needed to improve clinical management and prevention of acute respiratory infections (ARIs). keywords: acute; aris; children; infections; patients cache: cord-272538-gclrtie7.txt plain text: cord-272538-gclrtie7.txt item: #172 of 427 id: cord-272596-yxvg8357 author: WU, Jian Jun title: Detection of Human Bocavirus in Children with Acute Respiratory Tract Infections in Lanzhou and Nanjing, China date: 2014-11-30 words: 2965 flesch: 44 summary: The role of respiratory viral infections among children hospitalized for community-acquired pneumonia in a developing country Etiology of community-acquired pneumonia in hospitalized children based on WHO clinical guidelines Detection of human bocavirus in children with upper respiratory tract infection by polymerase chain reaction Detection of bocavirus in children suffering from acute respiratory tract infections in Saudi Arabia Surveillance and genome analysis of human bocavirus in patients with respiratory infection in Guangzhou, China Human bocavirus-the first 5 years Detection of human bocavirus from children and adults with acute respiratory tract illness in Guangzhou, southern China Detection of HBoV DNA in idiopathic lung fibrosis Primary and secondary human bocavirus 1 infections in a family Life-threatening respiratory tract disease with human bocavirus-1 infection in a 4-year-old child A newly identified bocavirus species in human stool A novel bocavirus associated with acute gastroenteritis in Australian children Human bocaviruses are highly diverse, dispersed, recombination prone, and prevalent in enteric infections Integrated management of childhood illness handbook Viral and atypical bacterial detection in acute respiratory infection in children under five years Human bocavirus in children hospitalized for acute gastroenteritis: a case-control study Development of three multiplex RT-PCR assays for the detection of 12 respiratory RNA viruses Human coronavirus NL63 infection in Canada Detection of the new human coronavirus HKU1: a report of 6 cases Detection of adenovirus in clinical specimens by polymerase chain reaction and liquid-phase hybridization quantitated by time-resolved fluorometry Correlation between bocavirus infection and humoral response, and co-infection with other respiratory viruses in children with acute respiratory infection Frequent and prolonged shedding of bocavirus in young children attending daycare Human bocavirus species 2 and 3 in Brazil Phylogenetic and recombination analysis of human bocavirus 2 High incidence of human bocavirus infection in children in Spain Seroepidemiology of human bocaviruses 1-4 Co-circulation of genetically distinct human metapneumovirus and human bocavirus strains in young children with respiratory tract infections in Italy Human bocavirus in Jordan: prevalence and clinical symptoms in hospitalised paediatric patients and molecular virus characterisation Human Bocavirus infection Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand Clinical relevance of human bocavirus with acute respiratory tract infection and diarrhea in children: a prospective case-control study Frequent detection of bocavirus DNA in German children with respiratory tract infections The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children High human bocavirus viral load is associated with disease severity in children under five years of age Human bocavirus infection in children with acute respiratory tract infection in India Human bocavirus in children with acute respiratory infections in Vietnam Human bocavirus, a newly discovered parvovirus of the respiratory tract Complete genome sequence of a novel reassortant H11N2 avian influenza virus isolated from a live poultry market in eastern China Distinct regulation of host responses by ERK and JNK MAP kinases in swine macrophages infected with pandemic (H1N1) 2009 influenza virus Human bocavirus in Italian patients with respiratory diseases Rapid detection of respiratory tract viral infections and coinfections in patients with influenza-like illnesses by use of reverse transcription-PCR DNA microarray systems Viruses and bacteria in sputum samples of children with community-acquired pneumonia Detection of head-to-tail DNA sequences of human bocavirus in clinical samples Human bocavirus infection in young children with acute respiratory tract infection in Lanzhou Does human bocavirus infection depend on helper viruses? The traditional viruses known to cause respiratory tract infections include adenovirus (ADV), influenza virus (IFV) A and B, human rhinoviruses (HRV), and respiratory syncytial virus (RSV). keywords: acute; bocavirus; children; hbov1; human; infection; tract; viruses cache: cord-272596-yxvg8357.txt plain text: cord-272596-yxvg8357.txt item: #173 of 427 id: cord-272878-6f0q661e author: Schnepf, Nathalie title: High Burden of Non-Influenza Viruses in Influenza-Like Illness in the Early Weeks of H1N1v Epidemic in France date: 2011-08-17 words: 4178 flesch: 40 summary: The interferon response circuit: induction and suppression by pathogenic viruses Situation épidémiologique de la bronchiolite Portrait of a year-old pandemic Detection of extensive cross-neutralization between pandemic and seasonal A/ H1N1 Influenza Viruses using a pseudotype neutralization assay Multiplex real-time PCR for detection of respiratory tract infections Frequent detection of viral coinfection in children hospitalized with acute respiratory tract infection using a real-time polymerase chain reaction Detection of multiple respiratory pathogens during primary respiratory infection: nasal swab versus nasopharyngeal aspirate using real-time polymerase chain reaction Prospective evaluation of a novel multiplex real-time PCR assay for detection of fifteen respiratory pathogens-duration of symptoms significantly affects detection rate Improving the clinical diagnosis of influenza-a comparative analysis of new influenza A (H1N1) cases Molecular diagnosis of respiratory viruses Detection of respiratory viruses by molecular methods Comprehensive diagnostics for respiratory virus infections after transplantation or after potential exposure to swine flu A/H1N1: what else is out there? Another possible explanation is better prevention behaviour about respiratory infections as recommended by a national campaign including recommendations for hands washing after sneezing and the use of mask [1] . keywords: assay; data; h1n1v; infections; influenza; pathogens; patients; positive; viruses cache: cord-272878-6f0q661e.txt plain text: cord-272878-6f0q661e.txt item: #174 of 427 id: cord-273620-gn8g6suq author: Szczawinska‐Poplonyk, Aleksandra title: Fatal respiratory distress syndrome due to coronavirus infection in a child with severe combined immunodeficiency date: 2012-11-30 words: 1452 flesch: 26 summary: However, it is worth noting that coronavirus respiratory infections have not been described in children with genetically determined immunodeficiencies thus far and this is the first report of a documented HCoV-HKU1-related pneumonia with the RDS in a child with SCID. In this report we present the case of a child with delayed-onset SCID and fatal respiratory coronavirus infection. keywords: children; coronavirus; hcov; human; infection cache: cord-273620-gn8g6suq.txt plain text: cord-273620-gn8g6suq.txt item: #175 of 427 id: cord-274007-zndtddty author: Rasmussen, Sonja A. title: Coronavirus Disease 2019 (COVID-19) and pregnancy: what obstetricians need to know date: 2020-02-24 words: 5921 flesch: 46 summary: Available at: https:// Expert Review ajog.org www.who.int/emergencies/diseases/novelcoronavirus-2019 Severe acute respiratory syndrome-related coronavirus: the species and its viruses-a statement of the Coronavirus Study Group Severe acute respiratory syndrome: Historical, epidemiologic, and clinical features the role of superspreaders in infectious disease Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome Infants born to mothers with severe acute respiratory syndrome SARS in newborns and children Emergency cesarean section in an epidemic of the middle east respiratory syndrome: a case report A casecontrolled study comparing clinical course and outcomes of pregnant and non-pregnant women with severe acute respiratory syndrome SARS and pregnancy: a case report SARS during pregnancy, United States Severe acute respiratory syndrome in pregnancy Specific immunoglobulin g antibody detected in umbilical blood and amniotic fluid from a pregnant woman infected by the coronavirus associated with severe acute respiratory syndrome Possible central nervous system infection by SARS coronavirus The effect of Severe Acute Respiratory Syndrome on a hospital obstetrics and gynaecology service Managing obstetrical patients during severe acute respiratory syndrome outbreak First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities Middle East respiratory syndrome (MERS) For severe acute respiratory syndrome, the largest series of 12 pregnancies had a case-fatality rate of 25%. keywords: cases; coronavirus; covid-19; infection; mers; patients; pregnancy; sars; syndrome; transmission; women cache: cord-274007-zndtddty.txt plain text: cord-274007-zndtddty.txt item: #176 of 427 id: cord-274127-12x5cc8i author: Jeong, Ji Hun title: Comparison of sputum and nasopharyngeal swabs for detection of respiratory viruses date: 2014-05-06 words: 2721 flesch: 46 summary: Nasopharyngeal versus oropharyngeal sampling Optimal sampling sites and methods for detection of pathogens possibly causing community-acquired lower respiratory tract infections Epidemiology of viral respiratory infections Laboratory detection of respiratory viruses by automated techniques Diagnosis of influenza in intensive care units: Lower respiratory tract samples are better than nose-throat swabs Diagnostic virology Comparison of different methods of total RNA extraction for viral detection in sputum Etiology and clinical characterization of respiratory virus infections in adult patients attending an emergency department in Beijing High incidence of multiple viral infections identified in upper respiratory tract infected children under three years of age in We thank Seegene Company for providing us with AnyplexTM II RV16. Molecular techniques have been used currently for respiratory virus detection with improved sensitivity, and multiplex real-time reverse transcription-polymerase chain reaction (RT-PCR) methods can detect simultaneously a number of viruses in a single assay. keywords: detection; nasopharyngeal; samples; sputum; swabs; viruses cache: cord-274127-12x5cc8i.txt plain text: cord-274127-12x5cc8i.txt item: #177 of 427 id: cord-274749-ji91qq9q author: Lagare, Adamou title: Viral and bacterial etiology of severe acute respiratory illness among children < 5 years of age without influenza in Niger date: 2015-11-14 words: 3583 flesch: 44 summary: Submit your manuscript at www.biomedcentral.com/submit Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis Estimate of worldwide distribution of child deaths from acute respiratory infections Respiratory viruses seasonality in children under five years of age in Viral etiologies of lower respiratory tract infections among Egyptian children under five years of age Respiratory viral coinfections identified by a 10-plex real-time reversetranscription polymerase chain reaction assay in patients hospitalised with severe acute respiratory illness-South Africa Viral etiology of influenza-like illness in Cameroon Clinical utility of PCR common viruses in acute respiratory illness Microbial aetiology of community-acquired pneumonia in hospitalised patients Clinico-pathological study of atypical pathogens in community-acquired pneumonia: a prospective study Epidemiology and clinical characteristics of community-acquired pneumonia in hospitalized children Carriage of Streptococcus pneumoniae and other respiratory bacterial pathogens in low and lower-middle income countries: a systematic review and meta-analysis Viral and bacterial detection in acute respiratory infection in children under five years Sentinel surveillance of influenza and other respiratory viruses, Brazil Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis Viral etiology of acute respiratory tract infection among pediatric inpatients and outpatients from 2010 to 2012 in Beijing, China Viral and atypical bacterial etiology of acute respiratory infections in children under 5 years old living in rural tropical area of Madagascar Viral etiology of respiratory infections in children under 5 years old living in tropical rural areas of Senegal: Nasopharyngeal specimens may be used to aid in the diagnosis of certain bacterial respiratory pathogens that do not tend to colonize the nasopharynx, such as M. pneumoniae and C. pneumoniae keywords: age; bacterial; children; influenza; respiratory; study; years cache: cord-274749-ji91qq9q.txt plain text: cord-274749-ji91qq9q.txt item: #178 of 427 id: cord-274763-i6e3g3te author: Liu, Wen-Kuan title: Epidemiology of HBoV1 infection and relationship with meteorological conditions in hospitalized pediatric patients with acute respiratory illness: a 7-year study in a subtropical region date: 2018-07-16 words: 3462 flesch: 41 summary: Cloning of a human parvovirus by molecular screening of respiratory tract samples Human Parvoviruses Virological and clinical characterizations of respiratory infections in hospitalized children Detection of human bocavirus type 1 infection in Panamanian children with respiratory illness Detection of human bocavirus in nasopharyngeal aspirates versus in broncho-alveolar lavage fluids in children with lower respiratory tract infections Human bocavirus detection in nasopharyngeal aspirates of children without clinical symptoms of respiratory infection Detection of bocavirus in saliva of children with and without respiratory illness B-cell responses to human Bocaviruses 1-4: new insights from a childhood follow-up study Seroepidemiology of human bocavirus defined using recombinant viruslike particles Seroepidemiology of human bocaviruses 1-4 The genomic and seroprevalence of human bocavirus in healthy Chinese plasma donors and plasma derivatives Human bocavirus: current knowledge and future challenges Spontaneous pneumomediastinum as a complication in human bocavirus infection Human bocavirus-the first 5 years Detection of human bocavirus from children and adults with acute respiratory tract illness in Guangzhou, southern China Comorbidity and high viral load linked to clinical presentation of respiratory human bocavirus infection Epidemic and molecular evolution of human bocavirus in hospitalized children with acute respiratory tract infection Human bocavirus amongst an all-ages population hospitalised with acute lower respiratory infections in Cambodia. Influenza Other Respir Viruses Human bocavirus in Chile: clinical characteristics and epidemiological profile in children with acute respiratory tract infections Single detection of human bocavirus 1 with a high viral load in severe respiratory tract infections in previously healthy children Human bocavirus as the cause of a life-threatening infection Clinical and microbiological impact of human bocavirus on children with acute otitis media Severe human bocavirus infection Clinical epidemiology and molecular profiling of human bocavirus in faecal samples from children with diarrhoea in Guangzhou Human bocavirus and acute wheezing in children Prevalence and clinical aspects of human bocavirus infection in children High incidence of human bocavirus infection in children in Spain Correlation between bocavirus infection and humoral response, and co-infection with other respiratory viruses in children with acute respiratory infection Human bocavirus in patients with encephalitis Identification of human bocaviruses in the cerebrospinal fluid of children hospitalized with encephalitis in China Detection of human bocavirus in the cerebrospinal fluid of children with encephalitis Detection and quantification of human bocavirus in river water Mixed viral infections causing acute gastroenteritis in children in a waterborne outbreak Frequent detection of highly diverse variants of cardiovirus, cosavirus, bocavirus, and circovirus in sewage samples collected in the United States In vitro modeling of human bocavirus 1 infection of polarized primary human airway epithelia Establishment of a reverse genetics system for studying human bocavirus in human airway epithelia Human bocavirus 1 infects commercially available primary human airway epithelium cultures productively Are meteorological parameters associated with acute respiratory tract infections? keywords: bocavirus; hbov1; human; infection; mean; patients; temperature cache: cord-274763-i6e3g3te.txt plain text: cord-274763-i6e3g3te.txt item: #179 of 427 id: cord-274900-s7ft1491 author: Tatarelli, P. title: Prevalence and clinical impact of VIral Respiratory tract infections in patients hospitalized for Community-Acquired Pneumonia: the VIRCAP study date: 2019-11-30 words: 3816 flesch: 32 summary: Viruses Rapid and sensitive method using multiplex real-time PCR for diagnosis of infections by influenza a and influenza B viruses, respiratory syncytial virus, and parainfluenza viruses 1, 2, 3, and 4 Polymerase chain reaction is more sensitive than viral culture and antigen testing for the detection of respiratory viruses in adults with hematological cancer and pneumonia Effect of rapid viral diagnosis on the management of children hospitalized with lower respiratory tract infection Cost-effectiveness of rapid diagnosis of viral respiratory tract infections in pediatric patients Viral infection in community-acquired pneumonia: a systematic review and meta-analysis Association of invasive pneumococcal disease with season, atmospheric conditions, air pollution, and the isolation of respiratory viruses Influenza alone and in sequence with pneumonia due to Streptococcus pneumoniae in the squirrel monkey Pulmonary antibacterial defenses during mild and severe influenza virus infection Acquired ciliary defects in nasal epithelium of children with acute viral upper respiratory infections Insights into the interaction between influenza virus and pneumococcus Respiratory viruses predisposing to bacterial infections: role of neuraminidase Pneumonia and Hong Kong influenza: a prospective study of the 1968-1969 epidemic Impact of preceding respiratory viral infections on the clinical severity of patients with Pneumococcal pneumonia Seasonal invasive pneumococcal disease in children: role of preceding respiratory viral infection Etiologic diagnosis of adult bacterial pneumonia by culture and PCR applied to respiratory tract samples Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak management of seasonal influenzaa Predicting death in patients hospitalized for community-acquired pneumonia key: cord-274900-s7ft1491 authors: Tatarelli, P.; Magnasco, L.; Borghesi, M. L.; Russo, C.; Marra, A.; Mirabella, M.; Sarteschi, G.; Ungaro, R.; Arcuri, C.; Murialdo, G.; Viscoli, C.; Del Bono, V.; Nicolini, L. A. title: Prevalence and clinical impact of VIral Respiratory tract infections in patients hospitalized for Community-Acquired Pneumonia: the VIRCAP study date: 2019-11-30 journal: Intern Emerg Med DOI: 10.1007/s11739-019-02243-9 sha: doc_id: 274900 cord_uid: s7ft1491 Prevalence and clinical impact of viral respiratory tract infections (VRTIs) on community-acquired pneumonia (CAP) has not been well defined so far. keywords: antibiotic; cap; influenza; patients; pneumonia; presence; respiratory; vrtis cache: cord-274900-s7ft1491.txt plain text: cord-274900-s7ft1491.txt item: #180 of 427 id: cord-275166-qduf08kp author: Assane, Dieng title: Viral and Bacterial Etiologies of Acute Respiratory Infections Among Children Under 5 Years in Senegal date: 2018-02-13 words: 1878 flesch: 37 summary: R Foundation for Statistical Computing Detection of viral and bacterial pathogens in acute respiratory infections Viral and bacterial aetiology of severe acute respiratory illness among children <5 years of age without influenza in Niger Respiratory viruses in patients with influenza like illness in Senegal: focus on human respiratory adenoviruses Respiratory viruses in children hospitalized for acute lower respiratory tract infection in Ghana Viral etiology of severe acute respiratory infections in hospitalized children in Cameroon Viral aetiology of respiratory infections in children in south-western Saudi Arabia using multiplex reverse transcriptase polymerase chain reaction Clinical disease severity of respiratory viral co-infection versus single viral infection: systematic review and analysis Viral and bacterial detection in acute respiratory infection in children under five years Bacterial and viral etiology in hospitalized community acquired pneumonia with molecular methods and clinical evaluation High nasopharyngeal pneumococcal increased by viral co-infection, is associated with invasive pneumococcal pneumonia Influenza virus infections were associated with single-virus coinfections (33.3%, n = 54) or virus and bacteria coinfections (12.35%, n = 20). keywords: children; infections; respiratory cache: cord-275166-qduf08kp.txt plain text: cord-275166-qduf08kp.txt item: #181 of 427 id: cord-275512-7yik78yc author: Lojkić, Ivana title: Detection and molecular characterisation of bovine corona and toroviruses from Croatian cattle date: 2015-08-13 words: 3321 flesch: 51 summary: Molecular Evolutionary Genetics Analysis Version 6.0 Phylogenetic Model Averaging Comparative sequence analysis of a polymorphic region of the spike glycoprotein S1 subunit of enteric bovine coronavirus isolates Analysis of the S spike (peplomer) glycoprotein of bovine coronavirus synthesized in insect cells Antigenic variation among bovine enteric coronaviruses (BECV) and bovine respiratory coronaviruses (BRCV) detected using monoclonal antibodies Isolation of bovine respiratory coronaviruses from feedlot cattle and comparison of their biological and antigenic properties with bovine enteric coronaviruses Antibody responses to respiratory coronavirus infections of cattle during shipping fever pathogenesis Nucleotide and predicted amino acid sequences of all genes encoded by the 3' genomic portion (9.5 kb) of respiratory bovine coronaviruses and comparisons among respiratory and enteric coronaviruses Bovine coronaviruses associated with enteric and respiratory diseases in Canadian dairy cattle display different reactivities to anti-HE monoclonal antibodies and distinct amino acid changes in their HE, S and ns4.9 protein Studies on the relationship between coronaviruses from the intestinal and respiratory tracts of calves Comparison of the S genes and the biological properties of respiratory and enteropathogenic bovine coronaviruses Failure to spread bovine virus diarrhoea virus infection from primarily infected calves despite concurrent infection with bovine coronavirus Tracing the transmission of bovine coronavirus infections in cattle herds based on S gene diversity Characterization of epidemic diarrhea outbreaks associated with bovine torovirus in adult cows Experimental inoculation of adult dairy cows with bovine coronavirus and detection of coronavirus in feces by RT-PCR Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • The S protein of bovine coronavirus is a hemagglutinin recognizing 9-O-acetylated sialic acid as a receptor determinant Two amino acid changes at the N-terminus of transmissible gastroenteritis coronavirus spike protein result in the loss of enteric tropism Detection and isolation of winter dysentery bovine coronavirus circulated in Korea during 2002-2004 Molecular epidemiology of bovine coronavirus on the basis of comparative analyses of the S gene The S2 subunit of the spike glycoprotein of bovine coronavirus mediates membrane fusion in insect cells Detection and characterization of bovine coronaviruses in fecal specimens of adult cattle with diarrhea during the warmer seasons Respiratory disease associated with bovine coronavirus infection in cattle herds in southern Italy Experimental reproduction of winter dysentery in lactating cows using BCOV -comparison with BCOV infection in milk-fed calves Bovine respiratory coronavirus The significance of bredavirus as a diarrhea agent in calf herds in Lower Saxony Detection of bovine torovirus in fecal specimens of calves with diarrhea from Ontario farms Torovirus detection in faecal specimens of calves and pigs in Hungary: short communication Phylogenetic and evolutionary relationships among torovirus field variants: evidence for multiple intertypic recombination events Molecular epidemiology of bovine toroviruses circulating in South Korea Epidemiological analysis of bovine torovirus in Japan Evaluation of a human group a rotavirus assay for on-site detection of bovine rotavirus Detection of bovine herpesvirus type 1 in blood from naturally infected cattle by using a sensitive PCR that discriminates between wild-type virus and virus lacking glycoprotein Restriction enzyme analysis of RT-PCR amplicons as a rapid method for detection of genetic diversity among bovine respiratory syncytial virus isolates Genetic typing of Croatian bovine viral diarrhea virus isolates. keywords: bcov; bovine; btov; calves; cattle; coronavirus; fecal; samples; sequences cache: cord-275512-7yik78yc.txt plain text: cord-275512-7yik78yc.txt item: #182 of 427 id: cord-275605-mbiojk39 author: Benkouiten, Samir title: Clinical respiratory infections and pneumonia during the Hajj pilgrimage: A systematic review date: 2018-12-04 words: 5820 flesch: 42 summary: The prevalence of acute respiratory symptoms and role of protective measures among Malaysian hajj pilgrims The association between pre-morbid conditions and respiratory tract manifestations amongst Malaysian Hajj pilgrims The inevitable Hajj cough: surveillance data in French pilgrims High prevalence of common respiratory viruses and no evidence of Middle East respiratory syndrome coronavirus in Hajj pilgrims returning to Ghana Respiratory viruses and bacteria among pilgrims during the Acquisition of Streptococcus pneumoniae carriage in pilgrims during the 2012 Hajj Pilot randomised controlled trial to test effectiveness of facemasks in preventing influenza-like illness transmission among Australian hajj pilgrims in 2011 Lack of MERS coronavirus but prevalence of influenza virus Circulation of respiratory viruses among pilgrims during the 2012 Hajj pilgrimage Lack of nasal carriage of novel corona virus (HCoV-EMC) in French Hajj pilgrims returning from the Hajj 2012, despite a high rate of respiratory symptoms Serological study of Bordetella Pertussis, Mycoplasma Pneumonia and Chlamydia Pneumonia in Iranian hajj pilgrims with prolonged cough illnesses: a follow-up study The prevalence and preventive measures of the respiratory illness among Malaysian pilgrims in 2013 Hajj season Influenza like illness (ILI): prevalence and preventive practices among Indian Haj pilgrims of Karnataka Impact of the Hajj on pneumococcal transmission Mass gathering and globalization of respiratory pathogens during the 2013 Hajj Viral respiratory infections among Hajj pilgrims in 2013 Acute febrile respiratory infection symptoms in Australian Hajjis at risk of exposure to Middle East respiratory syndrome coronavirus Relative risk for influenza like illness in French Hajj pilgrims compared to non-Hajj attending controls during the 2009 influenza pandemic Patterns of diseases and preventive measures among domestic hajjis from Central Patterns of diseases and preventive measures among domestic hajjis from Central, Saudi Arabia Protective practices and respiratory illness among US travelers to the Occurrence of acute respiratory infection, diarrhea and jaundice among Afghan pilgrims Pattern of diseases and preventive measures among domestic Hajjis from Riyadh, 1431 H Protective measures against acute respiratory symptoms in French pilgrims participating in the Hajj of Surveying respiratory infections among Iranian Hajj pilgrims Hajj-associated acute respiratory infection among hajjis from Riyadh Effect of the use of face mask on hajj related acute respiratory infection among Hajjis from Riyadh, a health promotion intervention study The comparison of influenza vaccine efficacy on respiratory diseases among Iranian pilgrims in the 2003 and 2004 seasons The incidence of influenza like illness and determination of the efficacy of Flu vaccine in Iranian pilgrims during Hajj pilgrimage Incidence of hajj-related acute respiratory infection among hajjis from Riyadh, 1423 H The incidence of vaccine preventable influenza-like illness and medication use among Pakistani pilgrims to the Haj in Saudi Arabia Cross-sectional survey and surveillance for influenza viruses and MERS-CoV among Egyptian pilgrims returning from Hajj during 2012-2015 Comparison of mortality and morbidity rates among Iranian pilgrims in Hajj Treatment and prevention of acute respiratory infections among Iranian hajj pilgrims: a 5-year follow up study and review of the literature Trend of diseases among S Iranian pilgrims during five consecutive years based on a Syndromic Surveillance System in Hajj Incidence of Hajj-associated febrile cough episodes among French pilgrims: a prospective cohort study on the influence of statin use and risk factors MERS-CoV but positive influenza viruses in returning Hajj pilgrims Effect of influenza vaccination on acute respiratory symptoms in Malaysian hajj pilgrims Time to revisit presumptions on the essentiality of influenza vaccination for hajj pilgrims: a prospective cohort study international Pandemic 2009 influenza A (H1N1) infection among 2009 Hajj Pilgrims from Southern Iran: a real-time RT-PCR-based study Health related experiences among international pilgrims departing through King Abdul Aziz international airport Effects of flu vaccine, solely or accompanied by pneumovax-23 vaccine on clinical consequences of the respiratory diseases among Iranian pilgrims in Hajj Influenza among U.K. pilgrims to hajj Medical problems of Pakistani pilgrims in Saudi Arabia Impact of pH1N1 influenza A infections on the otolaryngology, head and neck clinic during hajj Pattern of diseases among visitors to Mina health centers during the Hajj season, 1429 H (2008 G) Pattern of diseases among visitors to Mina health centers during the Hajj season Road map of an ear, nose, and throat clinic during the 2008 hajj in makkah, Saudi arabia Causes of hospitalization of pilgrims in the Hajj season of the Islamic year Pattern of surgical and medical diseases among pilgrims attending Alnoor hospital makkah Infections in travellers returning to Turkey from the Arabian peninsula: a retrospective cross-sectional multicenter study Clinical and temporal patterns of severe pneumonia causing critical illness during Hajj Severe sepsis and septic shock at the Hajj: etiologies and outcomes Pattern of diseases among visitors of health care facilities in Madinah during Hajj season, 1428 H (2007 G) Causes of admission to intensive care units in the Hajj period of the Islamic year 1424 Pattern of medical diseases and determinants of prognosis of hospitalization during Muslim pilgrimage Hajj in a tertiary care hospital. METHOD: The MEDLINE/PubMed and Scopus databases were searched for all relevant papers published prior to February 2018 that evaluated the prevalence of clinical symptoms of respiratory infections, including pneumonia, among Hajj pilgrims, as well as their influenza and pneumococcal vaccination status. keywords: cough; hajj; ili; influenza; pilgrims; respiratory; studies; study; symptoms; vaccine cache: cord-275605-mbiojk39.txt plain text: cord-275605-mbiojk39.txt item: #183 of 427 id: cord-275828-c6d6nk7x author: Mikasa, Keiichi title: JAID/JSC Guidelines for the Treatment of Respiratory Infectious Diseases: The Japanese Association for Infectious Diseases/Japanese Society of Chemotherapy – The JAID/JSC Guide to Clinical Management of Infectious Disease/Guideline-preparing Committee Respiratory Infectious Disease WG date: 2016-07-31 words: 39699 flesch: 37 summary: In the treatment of hospital-acquired pneumonia, the duration of antimicrobial therapy generally tends to be longer than required for the following reasons: opacity on chest X-ray often remains for reasons other than pneumonia even after the start of antimicrobial drug treatment; and there may be a large number of latent nonpneumonia (or non-infectious-disease) factors that may cause increase in body temperature or CRP level in inpatients (Table 5 GNR b ), the expression of intrinsic antimicrobial-drugresistance genes encoded in chromosome genes is induced during antimicrobial drug treatment, a phenomenon which is basically rarely seen in E. coli, Klebsiella spp., H. influenzae, and M. catarrhalis (Table 5 GNR a ) ( Table 5) keywords: administration; aspiration pneumonia; bacteria; cases; children; clinical; combination; community; day; days; diagnosis; disease; dose; drip; drug; drug therapy; guidelines; hospital; infection; japan; management; microorganisms; oral; patients; period; pneumonia; pulmonary; risk; severe; society; spp; study; susceptibility; symptoms; therapy; times; treatment; tuberculosis; type cache: cord-275828-c6d6nk7x.txt plain text: cord-275828-c6d6nk7x.txt item: #184 of 427 id: cord-276005-ifn88mjd author: da Silva Filho, Luiz Vicente Ribeiro Ferreira title: The Differential Clinical Impact of Human Coronavirus Species in Children With Cystic Fibrosis date: 2012-08-01 words: 2495 flesch: 38 summary: Patients with CF represent a specific population that is susceptible to more severe clinical manifestations of respiratory infections overall, because of limitations in mucocilliary transport and anatomic distortions of the bronchial tree that facilitate the retention and infection of respiratory secretions. No significant difference was found among patients with HCoV infection, with exacerbations identified on 6 of 19 occasions (31.5%) and hospital admissions on 2 of 19 occasions (10.5%). keywords: coronavirus; hcov; infections; nl63; patients; species; viruses cache: cord-276005-ifn88mjd.txt plain text: cord-276005-ifn88mjd.txt item: #185 of 427 id: cord-276348-vr5fit8r author: Ogra, Pearay L. title: Respiratory syncytial virus: The virus, the disease and the immune response date: 2004-01-31 words: 4792 flesch: 41 summary: Epidemiologic aspects of infection in infants and young children Respiratory syncytial virus neutralizing antibodies in persons residing in Chicago Respiratory syncytial virus Respiratory syncytial virus and parainfluenza virus Respiratory syncytial virus infections within families Neonatal respiratory syncytial virus infection Respiratory syncytial virus infections in immunocompromised adults Respiratory syncytial virus pneumonia in hospitalized adult patients with leukemia Respiratory viruses and sudden infant death Secretory component and sudden-infant death syndrome The antibody response to primary and secondary infection with respiratory syncytial virus: Kinetics of classspecific responses Immunoglobulin class-specific antibody response in respiratory syncytial virus infection measured by enzyme immunoassay Characteristics of in vitro production of mucosal antibody to respiratory syncytial virus in tonsillar tissue lymphocytes Neural mechanisms of respiratory syncytial virus-induced inflammation and prevention of respiratory syncytial virus sequelae Th1 and Th2 CD4+ cells in the pathogenesis of allergic diseases The development of respiratory syncytial virusspecific IgE and the release of histamine in nasopharyngeal secretions after infection Interleukin-1a mediates the enhanced expression of intercellular adhesion molecule-1 in pulmonary epithelial cells infected with respiratory syncytial virus Inducible translational regulation of the NF-IL6 transcription factor by respiratory syncytial virus infection in pulmonary epithelial cells Characteristics of IL-6 and TNF-a production by respiratory syncytial virus-infected macrophages in the neonate Clinical aspects of bronchial reactivity and cell-virus interaction Transcriptional activation of the interleukin-8 gene by respiratory syncytial virus infection in alveolar epithelial cells: Nuclear translocation of the RelA transcription factor as a mechanism producing airway mucosal inflamation Premature babies born at 30–35 weeks of gestation, infants with cyanotic congenital heart disease, HIV-infected subjects, and patients on intensive immunosuppressive therapy especially after bone marrow transplant are considered to be at risk for increased mortality and morbidity during RSV infection. keywords: cell; children; disease; infection; patients; proteins; respiratory; responses; rsv; virus cache: cord-276348-vr5fit8r.txt plain text: cord-276348-vr5fit8r.txt item: #186 of 427 id: cord-276927-rxudwp2v author: Barbas, Carmen Sílvia Valente title: Goal-Oriented Respiratory Management for Critically Ill Patients with Acute Respiratory Distress Syndrome date: 2012-08-23 words: 8003 flesch: 26 summary: Revaluation of ARDS patients on the third day of evolution (Sequential Organ Failure Assessment (SOFA), biomarkers and response to infection therapy) allows changes in the initial treatment plans and can help decrease ARDS mortality. Fibrosis can be evident histologically as early as one week after the onset of ARDS and procollagen III peptide, a precursor of collagen synthesis, can be elevated in bronchoalveolar lavage fluid of ARDS patients at the time of tracheal intubation, its increment being associated with a poor ARDS prognosis. keywords: acute; ards; distress; injury; lung; mortality; oxygenation; patients; peep; pressure; pulmonary; risk; study; syndrome; ventilation; ventilatory cache: cord-276927-rxudwp2v.txt plain text: cord-276927-rxudwp2v.txt item: #187 of 427 id: cord-277276-j2qzhvzi author: Al-Ayed, Mohamed S. title: Viral etiology of respiratory infections in children in southwestern Saudi Arabia using multiplex reverse-transcriptase polymerase chain reaction date: 2014 words: 2987 flesch: 44 summary: The burden of acute respiratory infections in crisisaffected populations: a systematic review Respiratory pathogens in children with and without respiratory symptoms Diagnostic value of respiratory virus detection in symptomatic children using real-time PCR Respiratory viruses in children hospitalized for acute lower respiratory tract infection in Ghana Virological and clinical characterizations of respiratory infections in hospitalized children Emerging respiratory agents: new viruses for old diseases? Novel respiratory virus infections in children Epidemiology and etiology of childhood pneumonia Treatment of the common cold in children and adults Detecting respiratory viruses in asymptomatic children Comparative evaluation of the Seegene Seeplex RV15 and real-time PCR for respiratory virus detection Rapid detection of respiratory tract viral infections and coinfections in patients with influenza-like illnesses by use of reverse transcription-PCR DNA microarray systems Detection and genotyping of human respiratory viruses in clinical specimens from children with acute respiratory tract infections Human metapneumovirus and human coronavirus infection and pathogenicity in Saudi children hospitalized with acute respiratory illness Detection of bocavirus in children suffering from acute respiratory tract infections in Saudi Arabia Prevalence of respiratory syncytial virus infection in Riyadh during the winter season 2007-2008 and different risk factors impact World Health Organization. Geneva (CH): World Health Organization Basic Laboratory Procedures in Clinical Microbiology Viral etiology of acute respiratory infection in Gansu Province Viral etiology of acute febrile respiratory illnesses in hospitalized children younger than 24 months Aetiology of influenza-like illness in adults includes parainfluenzavirus type 4 Multiple versus single virus respiratory infections: viral load and clinical disease severity in hospitalized children Epidemiology of respiratory viral infection using multiplex rt-PCR in Update on rhinovirus and coronavirus infections Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values Role of emerging respiratory viruses in children with severe acute wheezing Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology Human metapneumovirus: review of an important respiratory pathogen Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Brookline (MA): ProMed, International Society for Infectious Diseases keywords: children; detection; hrv; infections; pcr; saudi; study; viruses cache: cord-277276-j2qzhvzi.txt plain text: cord-277276-j2qzhvzi.txt item: #188 of 427 id: cord-277327-il8uaavn author: Couch, MD, Robert B. title: Respiratory Viral Infections in Immunocompetent and Immunocompromised Persons date: 1997-03-17 words: 3716 flesch: 26 summary: Pediatr Virus infections in children with acute lymphoblastic leukaemia Treatment of respiratory viral infection in an immunodeficient infant with ribavirin aerosol Ribavirin treatment of viral pneumonitis in severe combined immunodeficiency disease Parainfluenza 3 virus and other common respiratory pathogens in children with human immunodeficiency virus infection Respiratory syncytial virus (RSV) disease among hospitalized adult immunocompromised patients with leukemia Community respiratory virus infections among hospitalized adult bone marrow transplant recipients Epidemiology of influenza A virus infection in patients with acute or chronic leukemia Influenza among hospitalized adult immunocompromised patients with leukemia Community respiratory virus (CRV) infections in hospitalized adult patients with leukemia Host defenses at mucosal surfaces Immunoglobulin A in secretions from the lower respiratory tract The specificity and function of T lymphocytes induced by influenza A viruses Roles of ab and gd T cell subsets in viral immunity The kinetics of immune reconstitution after human marrow transplantation Influenza in children with cancer Viral pneumonia in recipients of solid organ transplants Influenza A in immunocompromised patients Orthomyxoviral and paramyxoviral infections in transplant patients Bone marrow transplantation for malignant disease Intranasal interferon as protection against experimental respiratory coronavirus infection in volunteers Prevention of natural colds by contact prophylaxis with intranasal alpha2-interferon The efficacy of intranasal interferon a-2a in respiratory syncytial virus infection in volunteers. This article is an overview of respiratory viral infections in both immunocompetent and immunocompromised persons. keywords: disease; infection; influenza; patients; persons; pneumonia; virus; viruses cache: cord-277327-il8uaavn.txt plain text: cord-277327-il8uaavn.txt item: #189 of 427 id: cord-278031-vpq4yghn author: Zumla, Alimuddin title: Rapid diagnostics urgently needed for killer infections date: 2013-06-30 words: 1140 flesch: 40 summary: Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world? Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis Frequency, diagnosis and management of fungal respiratory infections Bacterial coinfection in infl uenza: a grand rounds review Co-infections with infl uenza and other respiratory viruses Tuberculosis comorbidity with communicable and non-communicable diseases: integrating health services and control eff orts Deaths due to respiratory tract infections in Africa: a review of autopsy studies Epidemiological characteristics of cases for infl uenza A (H7N9) virus infections in China Respiratory tract infections during the annual Hajj: potential risks and mitigation strategies Advances in tuberculosis diagnostics: the Xpert MTB/RIF assay and future prospects for a point-of-care test Evaluation of a rapid lateral fl ow immunoassay for Staphylococcus aureus detection in respiratory samples Are we ready for novel detection methods to treat respiratory pathogens in hospital-acquired pneumonia? The absence of rapid accurate diagnostic tests for pulmonary tuberculosis was further compounded by the widespread inability to screen for drug-resistant bacteria. keywords: infections; infl; rtis; uenza cache: cord-278031-vpq4yghn.txt plain text: cord-278031-vpq4yghn.txt item: #190 of 427 id: cord-278935-3lgud7l8 author: Chen, Zheng‐Rong title: Clinical and epidemiological profiles of lower respiratory tract infection in hospitalized children due to human bocavirus in a subtropical area of China date: 2014-04-30 words: 4782 flesch: 43 summary: Although few studies have investigated the epidemiological files of HBoV infection in children with lower respiratory tract infection in subtropical area in China, a possible relationship between meteorological factors and incidence of HBoV is currently unknown. The ratio of male to female children with HBoV infection was 1.67:1 and no gender difference was observed in the incidence of HBoV infection compared with total children with lower respiratory tract infection (male to female, HBoV infected children 1.7 vs. total children 1.7, P > 0.05). keywords: bocavirus; children; et al; hbov; human; infection; study; tract cache: cord-278935-3lgud7l8.txt plain text: cord-278935-3lgud7l8.txt item: #191 of 427 id: cord-279257-a7d9a2w1 author: Puig, Carme title: Incidence and risk factors of lower respiratory tract illnesses during infancy in a Mediterranean birth cohort date: 2008-07-09 words: 3536 flesch: 44 summary: Lower respiratory tract illness in the first year of life Prospective population-based study of viral lower respiratory tract infections in children under 3 years of age (the PRIDE study) Economic impact of communityacquired and nosocomial lower respiratory tract infections in young children in Germany Asthma and immunoglobulin E antibodies after respiratory syncitial virus bronchiolitis: a prospective cohort study with matched controls Do lower respiratory tract infections in early childhood cause chronic obstructive pulmonary disease? The aim of the present study was to determine the incidence rate of LRTIs during infancy, identify viral respiratory Abbreviations AMICS, asthma multicenter infant cohort study; Der p1, Dermatophagoides pteronyssinus 1; ETS: environmental tobacco smoke; Fel d1, Felus domesticus 1; LRTI, lower respiratory tract illness; NO 2 , nitrogen dioxide; NO-LRTI, no lower respiratory tract illness; NPA, nasopharyngeal aspirate; RSV, respiratory syncytial virus; SES, socioeconomic status. keywords: asthma; cohort; infants; lrti; risk; study; tract; virus cache: cord-279257-a7d9a2w1.txt plain text: cord-279257-a7d9a2w1.txt item: #192 of 427 id: cord-279421-rxocrgfu author: Zhang, Dan title: Clinical Evaluation of a Single-Tube Multiple RT-PCR Assay for the Detection of 13 Common Virus Types/Subtypes Associated with Acute Respiratory Infection date: 2016-04-04 words: 2865 flesch: 42 summary: In conclusion, our results demonstrates the one-tube assay revealed significant improvements over the two-tube assay in terms of the better sensitivity, more accurate quality control, less nonspecific amplification, more cost-effective and shorter turn-around time and will be a valuable tool for routine surveillance of respiratory virus infection in China. The aim of this study is to provide a high throughput screening method for routine surveillance of respiratory virus infection in provincial and local Centers for Disease Control and Prevention, China. keywords: assay; detection; study; tube; tube assay; virus; viruses cache: cord-279421-rxocrgfu.txt plain text: cord-279421-rxocrgfu.txt item: #193 of 427 id: cord-280732-u0pncmp0 author: Nicolas, J. C. title: Entérovirus et infections respiratoires date: 1976-09-30 words: 1137 flesch: 39 summary: The relationship between the enteroviruses and respiratory infections remains to be proved. A report of an outbreak with the isolation of type 19 Echovirus on one case -Clinical syndroms in chiidren caused by respiratory infection Airborne transmission of respiratory infection with Coxsackievirus A type 21 Respiratory illness in six infants infected with a newly recognized Echovirus. pediatrics Group B Coxsackievirus infection in infant with acute lower respiratory disease -An outbreak of Coxsackievirus type 22 among neonates in an obstetrical ward -Echovirus type 17 in the neonate Histological study of two cases of Coxsackie B virus pneumonia in children Pneumopathies interstitielles chez l'enfant Pneumopathies interstitielles d'origine infec Outbreak of febrile illness associated with Echovirus type 5 in a maternity unit in Singapore Clinical and serological observations in cases of Coxsackie B3 infections in early infancy -prospective study of mixed Coxsaekie virus B3 and B4 outbreak of upper respiratory illness in a children's home Respiratory viral infection in childhood. keywords: des; echovirus; infections; virus cache: cord-280732-u0pncmp0.txt plain text: cord-280732-u0pncmp0.txt item: #194 of 427 id: cord-280857-0o1ikwks author: Goligher, Ewan C. title: Clinical strategies for implementing lung and diaphragm-protective ventilation: avoiding insufficient and excessive effort date: 2020-11-02 words: 6146 flesch: 20 summary: pathophysiology and clinical implications The injurious effects of elevated or nonelevated respiratory rate during mechanical ventilation Effects of short-term oxygenation changes on acute lung injury patients undergoing pressure support ventilation Effects of pressure ramp slope values on the work of breathing during pressure support ventilation in restrictive patients Volume-controlled ventilation does not prevent injurious inflation during spontaneous effort Neural control of mechanical ventilation in respiratory failure Comparison between neurally adjusted ventilatory assist and pressure support ventilation levels in terms of respiratory effort Neurally adjusted ventilatory assist versus pressure support ventilation in difficult weaning: a randomized trial Neurally adjusted ventilatory assist in acute respiratory failure: a randomized controlled trial Fifty years of research in ARDS. Monitoring and controlling respiratory muscle effort are major challenges in implementing lung and diaphragm-protective mechanical ventilation. keywords: diaphragm; drive; effort; injury; lung; patients; pressure; protective; sedation; stress; ventilation cache: cord-280857-0o1ikwks.txt plain text: cord-280857-0o1ikwks.txt item: #195 of 427 id: cord-281051-i229xv0o author: Bishop-Williams, Katherine E. title: A protocol for a systematic literature review: comparing the impact of seasonal and meteorological parameters on acute respiratory infections in Indigenous and non-Indigenous peoples date: 2017-01-26 words: 6406 flesch: 38 summary: Globally, Indigenous peoples may experience a different burden of ARI compared to non-Indigenous peoples. The results can be presented in one of two eligible ways: (i) two models representing the Indigenous and non-Indigenous strata separately with the same seasonal or meteorological parameter in both models, producing two measures of association for which the ratio of odds ratios (ROR) can be calculated (i.e., ARI-exposure model for Indigenous peoples and ARI-exposure model for non-Indigenous peoples); or (ii) a model for an ARI outcome that includes indigeneity and seasonal or meteorological parameter(s) as independent variables from which further calculations can be made (Fig. 1) . keywords: ari; data; exposure; parameters; peoples; population; review; screening; search; studies; study cache: cord-281051-i229xv0o.txt plain text: cord-281051-i229xv0o.txt item: #196 of 427 id: cord-281085-lqniqui0 author: Nosalova, Gabriela title: Pharmacological modulation of cough reflex date: 2006-12-31 words: 6995 flesch: 41 summary: The anatomical localization of cough receptors in the airways enables the use of local anesthetics Reynolds et al., 2004) , which could Tilidin 10 mg/kg i.p. Fig. 7 . The inhalation of anesthetizing aerosols leads to desensitization of cough receptors as well as other segments of mucous membranes in the mouth, and the upper and lower parts of the respiratory system, and increases the risk of aspiration . keywords: activity; agents; airways; cough; drugs; et al; group; nosalova; receptors; reflex; therapy; treatment cache: cord-281085-lqniqui0.txt plain text: cord-281085-lqniqui0.txt item: #197 of 427 id: cord-281418-mvgp6qfv author: Soccal, P. M. title: Upper and Lower Respiratory Tract Viral Infections and Acute Graft Rejection in Lung Transplant Recipients date: 2010-07-15 words: 3563 flesch: 35 summary: Clinical impact of communityacquired respiratory viruses on bronchiolitis obliterans after lung transplant Impact of human metapneumovirus and human cytomegalovirus versus other respiratory viruses on the lower respiratory tract infections of lung transplant recipients Respiratory viruses and chronic rejection in lung transplant recipients Human metapneumovirus in lung transplant recipients and comparison to respiratory syncytial virus Respiratory viral infections in transplant recipients A single-season prospective study of respiratory viral infections in lung transplant recipients Absence of human bocavirus in bronchoalveolar lavage fluid of lung transplant patients Diagnosis of human metapneumovirus infection in immunosuppressed lung transplant recipients and children evaluated for pertussis Detection of severe human metapneumovirus infection by real-time polymerase chain reaction and histopathological assessment Human metapneumovirus infection in lung transplant recipients: clinical presentation and epidemiology Lower respiratory viral illnesses: improved diagnosis by molecular methods and clinical impact Respiratory viral infections are a distinct risk for bronchiolitis obliterans syndrome and death Clinical features and outcomes of paramyxoviral infection in lung transplant recipients treated with ribavirin Infectious etiology of bronchiolitis obliterans: the respiratory viruses connection: myth or reality? Characterization of virus-mediated inhibition of mixed chimerism and allospecific tolerance Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome Community acquired respiratory viral infections after lung transplantation: clinical features and long-term consequences Parainfluenza virus infection in adult lung transplant recipients: an emergent clinical syndrome with implications on allograft function The epidemiology of parainfluenza virus infection in lung transplant recipients Treatment of respiratory syncytial virus pneumonia in a lung transplant recipient: case report and review of the literature Influenza virus infection in adult solid organ transplant recipients Respiratory viruses in bronchoalveolar lavage: a hospital-based cohort study in adults A prospective hospital-based study of the clinical impact of non-severe acute respiratory syndrome (non-SARS)-related human coronavirus infection Swiss Paediatric Respiratory Research Group. Paradoxically, we even observed a negative association between an episode of respiratory viral infection and the subsequent cumulative risk of developing acute rejection. keywords: bal; infection; lung; presence; rejection; transplant; viruses cache: cord-281418-mvgp6qfv.txt plain text: cord-281418-mvgp6qfv.txt item: #198 of 427 id: cord-281754-auqh3vtr author: None title: EMERGING RESPIRATORY DISEASE - CORONAVIRUSES date: 2017-09-12 words: 3627 flesch: 45 summary: By the end of 2003, according to the CDC report of WHO data, reports of SARS infections from 29 countries and regions revealed 8,096 persons with probable SARS resulting in 774 deathswith an estimated case fatality rate just below 10% (higher in elderly, infirm patients). SARS CoV keywords: avian; coronavirus; cov; h7n9; human; illness; infections; influenza; sars; syndrome cache: cord-281754-auqh3vtr.txt plain text: cord-281754-auqh3vtr.txt item: #199 of 427 id: cord-281916-v6u5mr2i author: Bonnin, Paul title: Study and interest of cellular load in respiratory samples for the optimization of molecular virological diagnosis in clinical practice date: 2016-08-09 words: 4127 flesch: 40 summary: The underrecognized burden of influenza in young children Viral epidemiology and severity of respiratory infections in infants in 2009: a prospective study Techniques actuelles de diagnostic des infections virales respiratoires en réanimation Cost analysis of multiplex PCR testing for diagnosing respiratory virus infections Superiority of reverse-transcription polymerase chain reaction to conventional viral culture in the diagnosis of acute respiratory tract infections in children Increased detection of respiratory syncytial virus, influenza viruses, parainfluenza viruses, and adenoviruses with real-time PCR in samples from patients with respiratory symptoms Quantitation of respiratory syncytial virus RNA in nasal aspirates of children by real-time RT-PCR assay Molecular diagnosis of respiratory viruses Comparison of multiplex PCR assays and conventional techniques for the diagnostic of respiratory virus infections in children admitted to hospital with an acute respiratory illness Comparative evaluation of six commercialized multiplex PCR kits for the diagnosis of respiratory infections Identification of respiratory viruses in adults: nasopharyngeal versus sampling Development of an efficient qRT-PCR assay for quality control and cellular quantification of respiratory samples Guideline to reference gene selection for quantitative realtime PCR Comparison of flocked and rayon swabs for collection of respiratory epithelial cells from uninfected volunteers and symptomatic patients Nasal swab samples and real-time polymerase chain reaction assays in community-based, longitudinal studies of respiratory viruses: the importance of sample integrity and quality control Swabbing for respiratory viral infections in older patients:a comparison of rayon and nylon flocked swabs Comparison among nasopharyngeal swab, nasal wash, and oropharyngeal swab for respiratory virus detection in adults with acute pharyngitis Improved detection of respiratory viruses in pediatric outpatients with acute respiratory illness by real-time PCR using nasopharyngeal flocked swabs Comparison of nasopharyngeal and oropharyngeal swabs for the diagnosis of eight respiratory viruses by real-time reverse transcription-PCR assays Evaluation of the Quidel QuickVue test for detection of influenza A and B viruses in the pediatric emergency medicine setting by use of three specimen collection methods A quantification of human cells using an ERV-3 real time PCR assay Not applicable. key: cord-281916-v6u5mr2i authors: Bonnin, Paul; Miszczak, Fabien; Kin, Nathalie; Resa, Cecile; Dina, Julia; Gouarin, Stephanie; Viron, Florent; Morello, Remy; Vabret, Astrid title: Study and interest of cellular load in respiratory samples for the optimization of molecular virological diagnosis in clinical practice date: 2016-08-09 journal: BMC Infect Dis DOI: 10.1186/s12879-016-1730-9 sha: doc_id: 281916 cord_uid: v6u5mr2i BACKGROUND: Respiratory viral diagnosis of upper respiratory tract infections has largely developed through multiplex molecular techniques. keywords: age; cellularity; detection; diagnosis; pcr; samples; study cache: cord-281916-v6u5mr2i.txt plain text: cord-281916-v6u5mr2i.txt item: #200 of 427 id: cord-282303-idh7io9v author: Hassan, Md. Zakiul title: Contamination of hospital surfaces with respiratory pathogens in Bangladesh date: 2019-10-28 words: 4160 flesch: 32 summary: Muzahidul; Rahman, Mahmudur; Gurley, Emily S. title: Contamination of hospital surfaces with respiratory pathogens in Bangladesh date: 2019-10-28 journal: PLoS One DOI: 10.1371/journal.pone.0224065 sha: doc_id: 282303 cord_uid: idh7io9v With limited infection control practices in overcrowded Bangladeshi hospitals, surfaces may play an important role in the transmission of respiratory pathogens in hospital wards and pose a serious risk of infection for patients, health care workers, caregivers and visitors. Respiratory viral and bacterial pathogens, including Staphylococcus aureus, Streptococcus pyogenes, influenza viruses, respiratory syncytial virus, adenovirus, rhinoviruses and novel coronavirus strains, can survive on hospital surfaces for days, weeks or even months. keywords: hospital; infection; pathogens; patients; pneumoniae; respiratory; surfaces; swabs; wards cache: cord-282303-idh7io9v.txt plain text: cord-282303-idh7io9v.txt item: #201 of 427 id: cord-282420-0fcyjw7l author: Lu, Cheng-wei title: 2019-nCoV transmission through the ocular surface must not be ignored date: 2020-02-06 words: 310 flesch: 49 summary: The fact that exposed mucous membranes and unprotected eyes increased the risk of SARSCoV transmission 4 suggests that exposure of unprotected eyes to 2019nCoV could cause acute respiratory infection. Thus, Huang and colleagues 1 should have analysed conjunctival scrapings from both confirmed and suspected 2019nCoV cases during the onset of symptoms. keywords: eyes cache: cord-282420-0fcyjw7l.txt plain text: cord-282420-0fcyjw7l.txt item: #202 of 427 id: cord-282533-w6kl74c8 author: Li, Jin title: Rapid detection of respiratory organisms with the FilmArray respiratory panel in a large children’s hospital in China date: 2018-10-11 words: 3389 flesch: 39 summary: Epidemiology of viral respiratory infections Community-acquired pneumonia requiring hospitalization among U.S. children Epidemiology of acute respiratory infections in children in Guangzhou: a three-year study Seroprevalence of pertussis in China: need to improve vaccination strategies The seroepidemiology of immunoglobulin G antibodies against pertussis toxin in China: a cross sectional study Routine molecular point-of-care testing for respiratory viruses in adults presenting to hospital with acute respiratory illness (ResPOC): a pragmatic, open-label, randomised controlled trial Multiplex PCR and emerging technologies for the detection of respiratory pathogens an automated nested multiplex PCR system for multi-pathogen detection: development and application to respiratory tract infection Charnot-Katsikas A. Comparison of Cepheid Xpert flu/RSV XC and BioFire FilmArray for detection of influenza a, influenza B, and respiratory syncytial virus Comparison of the FilmArray assay and in-house real-time PCR for detection of respiratory infection Comparison of FilmArray respiratory panel and laboratory-developed real-time reverse transcriptionpolymerase chain reaction assays for respiratory virus detection Comparison of the FilmArray respiratory panel and Prodesse real-time PCR assays for detection of respiratory pathogens FilmArray(R) respiratory panel performance in respiratory samples from neonatal care units Seasonality and prevalence of respiratory pathogens detected by multiplex PCR at a tertiary care medical center Human metapneumovirus subgroup changes and seasonality during epidemics Seasonality, incidence, and repeat human metapneumovirus lower respiratory tract infections in an area with a high prevalence of human immunodeficiency virus type-1 infection Etiologic spectrum and occurrence of coinfections in children hospitalized with community-acquired pneumonia Performance of a novel microarray multiplex PCR for the detection of 23 respiratory pathogens (SYMP-ARI study) In the present study, patients suspected of having pertussis were diagnosed with pertussis when B. pertussis was positive by FilmArray RP detection and were otherwise diagnosed with pertussis-like syndrome. keywords: age; children; detection; filmarray; patients; pertussis; pneumoniae cache: cord-282533-w6kl74c8.txt plain text: cord-282533-w6kl74c8.txt item: #203 of 427 id: cord-282668-bs634hti author: Niang, Mbayame Ndiaye title: Respiratory viruses in patients with influenza-like illness in Senegal: Focus on human respiratory adenoviruses date: 2017-03-22 words: 4627 flesch: 42 summary: Molecular Evolutionary Genetics Analysis version 6.0 Epidemiology of respiratory viral infections in two long-term refugee camps in Kenya Viral etiology and seasonality of influenza-like illness in Gabon Epidemiology of respiratory viral infection using multiplex rt-PCR in Laboratory Surveillance of Influenza-Like Illness in Seven Teaching Hospitals The clinical and etiological characteristics of influenza-like illness (ILI) in outpatients in Temporal changes in respiratory adenovirus serotypes circulating in the greater Toronto area Adenovirus respiratory tract infections in Peru Sentinel surveillance of influenza-like illness in two hospitals in Respiratory viral infections during the 2009-2010 winter season in Central England, UK: incidence and patterns of multiple virus co-infections Viral etiology of severe acute respiratory infections in hospitalized children in Cameroon The role of respiratory viral infections among children hospitalized for community-acquired pneumonia in a developing country Respiratory Virus Detection and Clinical Diagnosis in Children Attending Day Care Surveillance for severe acute respiratory infections in Southern Arizona Epidemiology of human respiratory viruses in children with acute respiratory tract infections in Jinan, China Respiratory viral infection in lower airways of asymptomatic children Viral and Other Infections of the Human Respiratory Tract The epidemiology of adenovirus infections in Greater Manchester, UK 1982-96 Estimates of world-wide distribution of child deaths from acute respiratory infections Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis Molecular identification of adenoviruses associated with respiratory infection in Egypt from Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China Feigin RD, Cherry JD. keywords: adenovirus; children; detection; hadv; human; infections; influenza; patients; senegal; species; study; years cache: cord-282668-bs634hti.txt plain text: cord-282668-bs634hti.txt item: #204 of 427 id: cord-282867-kbyxdegu author: Shah, Sayed Zulfiqar Ali title: Scaling the Need, Benefits, and Risks Associated with COVID-19 Acute and Postacute Care Rehabilitation: A Review date: 2020-08-26 words: 4550 flesch: 35 summary: Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents Rehabilitation Research and Practice Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors Six month radiological and physiological outcomes in severe acute respiratory syndrome (SARS) survivors A major outbreak of severe acute respiratory syndrome in Hong Kong Rehabilitation and respiratory management in the acute and early post-acute phase Pathogenesis and natural history of osteonecrosis Avascular necrosis of bone in severe acute respiratory syndrome Steroidinduced osteonecrosis in severe acute respiratory syndrome: a retrospective analysis of biochemical markers of bone metabolism and corticosteroid therapy Chest physiotherapy for pneumonia in adults Chest physiotherapy in primary pneumonia Epidemiology and outcome of acute respiratory failure in intensive care unit patients Effects of sputum on pulmonary function A randomised controlled trial of the effectiveness of an exercise training program in patients recovering from severe acute respiratory syndrome Pulmonary rehabilitation for patients with coronavirus disease 2019 (COVID-19) Acute care physiotherapy management of COVID-19 patients in Qatar: consensus-based recommendations A randomized evaluation of the acute efficacy, acceptability and tolerability of flutter and active cycle of breathing with and without postural drainage in non-cystic fibrosis bronchiectasis Endotracheal suction in intubated critically ill adult patients undergoing mechanical ventilation: a systematic review Chest physiotherapy in mechanically ventilated patients without pneumonia-a narrative review Chest physical therapy for children hospitalised with acute pneumonia: a randomised controlled trial Long-term comparative trial of two different physiotherapy techniques; postural drainage with percussion and autogenic drainage, in the treatment of cystic fibrosis Efficacy and safety of early prone positioning combined with HFNC or NIV in moderate to severe ARDS: a multi-center prospective cohort study Respiratory physiotherapy in patients with COVID-19 infection in acute setting: a position paper of the Italian Association of Respiratory Physiotherapists (ARIR) According to consensus-based acute care physiotherapy recommendations developed in Qatar, rehabilitation patients could be categorized into the following six categories: Category A (paralyzed, ventilated, and sedated), Category B (ventilated and minimally sedated), Category C (no mechanical ventilation), Category C.1 (bedridden but minimally conscious), Category C.2 (conscious and active but dependent), and Category C.3 (independent, active, and conscious). keywords: acute; chest; coronavirus; covid-19; patients; physiotherapy; pneumonia; rehabilitation; sars; syndrome; techniques; treatment cache: cord-282867-kbyxdegu.txt plain text: cord-282867-kbyxdegu.txt item: #205 of 427 id: cord-283399-iz4l9i0d author: O’Gorman, C. title: Human metapneumovirus in adults: a short case series date: 2006-03-14 words: 1486 flesch: 38 summary: It is clear that respiratory viruses are the principal pathogens in a proportion of such cases [4] . The routine assay used to detect respiratory viruses in the regional virus laboratory is a multiplex, nested RT-PCR for 12 common respiratory pathogens: influenza A (H3 and H1) and B; parainfluenza virus types 1, 2 and 3; respiratory syncytial virus A and B; adenovirus; human rhinovirus; coronavirus 229E; and hMPV. keywords: adults; cases; hmpv; patients; virus cache: cord-283399-iz4l9i0d.txt plain text: cord-283399-iz4l9i0d.txt item: #206 of 427 id: cord-283604-fqc9jp0l author: Chen, Meng title: Adenoviruses Associated with Acute Respiratory Diseases Reported in Beijing from 2011 to 2013 date: 2015-03-27 words: 3066 flesch: 36 summary: Seventh Report of the International Committee on Taxonomy of Viruses New adenovirus species found in a patient presenting with gastroenteritis Evidence of frequent recombination among human adenoviruses Molecular and serological characterization of species B2 adenovirus strains isolated from children hospitalized with acute respiratory disease in Genome sequence of a novel virus of the species human adenovirus d associated with acute gastroenteritis Molecular epidemiology of human adenoviruses d associated with epidemic keratoconjunctivitis in Rapid detection of adenovirus in throat swab specimens by PCR during respiratory disease outbreaks among military recruits Abrupt emergence of diverse species B adenoviruses at US military recruit training centers Multiplexed Luminex xMAP assay for detection and identification of five adenovirus serotypes associated with epidemics of respiratory disease in adults Outbreak of acute respiratory disease in China caused by B2 species of adenovirus type 11 Genomic analyses of recombinant adenovirus type 11a in China High incidence of multiple viral infections identified in upper respiratory tract infected children under three years of age in MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods Detection of three human adenovirus species in adults with acute respiratory infection in China Human adenovirus infection in children with acute respiratory tract disease in Guangzhou Prevalence of adenovirus in children with acute respiratory tract infection in Lanzhou, China Molecular typing of adenoviruses in pediatric respiratory infections in Molecular epidemiology and clinical presentation of human adenovirus infections in Kansas City children Molecular identification of adenoviruses associated with respiratory infection in Egypt from Lower respiratory tract infections due to adenovirus in hospitalized Korean children: epidemiology, clinical features, and prognosis Natural variants of human adenovirus type 3 provide evidence for relative genome stability across time and geographic space Genomic and bioinformatics analyses of HAdV-4vac and HAdV-7vac, two human adenovirus (HAdV) strains that constituted original prophylaxis against HAdV-related acute respiratory disease, a reemerging epidemic disease Computational analysis of adenovirus serotype 5 (HAdV-C5) from an HAdV coinfection shows genome stability after 45 years of circulation Outbreak of febrile respiratory illness associated with adenovirus 11a infection in a Singapore military training cAMP Emergence of community-acquired adenovirus type 55 as a cause of community-onset pneumonia Severe community-acquired pneumonia caused by adenovirus type 11 in immunocompetent adults in Beijing Epidemiology of human adenovirus and molecular characterization of human adenovirus 55 in China Evidence of molecular evolution driven by recombination events influencing tropism in a novel human adenovirus that causes epidemic keratoconjunctivitis Computational analysis identifies human adenovirus type 55 as a re-emergent acute respiratory disease pathogen We thank all the laboratory staffs and the epidemiologists in Beijing Center for Disease Control and Prevention and team members in the projects. key: cord-283604-fqc9jp0l authors: Chen, Meng; Zhu, Zhen; Huang, Fang; Liu, Donglei; Zhang, Tiegang; Ying, Deng; Wu, Jiang; Xu, Wenbo title: Adenoviruses Associated with Acute Respiratory Diseases Reported in Beijing from 2011 to 2013 date: 2015-03-27 journal: PLoS One DOI: 10.1371/journal.pone.0121375 sha: doc_id: 283604 cord_uid: fqc9jp0l BACKGROUND: Adenovirus is one of the most common causes of viral acute respiratory infections. keywords: adenovirus; gene; hadv; human; infection; species; study; type cache: cord-283604-fqc9jp0l.txt plain text: cord-283604-fqc9jp0l.txt item: #207 of 427 id: cord-283910-k10j5dzd author: Fretzayas, Andrew title: Etiology and clinical features of viral bronchiolitis in infancy date: 2017-05-04 words: 4687 flesch: 38 summary: I. Isolation, properties and characterization Diagnosis and testing in bronchiolitis: a systematic review Respiratory syncytial virus-associated hospitalizations among infants and young children in the United States Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture Clinical features, adenovirus types, and local production of inflammatory mediators in adenovirus infections Adenoviral infections in children: the impact of rapid diagnosis Adenovirus respiratory infection in hospitalized children in Hong Kong: serotype-clinical syndrome association and risk factors for lower respiratory tract infection What is the clinical relevance of respiratory syncytial virus bronchiolitis?: findings from a multi-center, prospective study The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis Infection with multiple viruses is not associated with increased disease severity in children with bronchiolitis The isolation of a new virus associated with respiratory clinical disease in humans Detection of new respiratory viruses in hospitalized infants with bronchiolitis: a three-year prospective study In very young infants severity of acute bronchiolitis depends on carried viruses Broad respiratory virus detection in infants hospitalized for bronchiolitis by use of a multiplex RT-PCR DNA microarray system Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants Clinical risk factors are more relevant than respiratory viruses in predicting bronchiolitis severity Association of rhinovirus infection with increased disease severity in acute bronchiolitis Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis Rhinovirus bronchiolitis and recurrent wheezing: 1-year follow-up Rhinovirus-induced bronchiolitis and asthma development A newly discovered human pneumovirus isolated from young children with respiratory tract disease Human Metapneumovirus as a causative agent of acute bronchiolitis in infants Detection of human metapneumovirus RNA sequences in nasopharyngeal aspirates of young Frenchchildren with acute bronchiolitis by real-time reverse transcriptase PCR and phylogenetic analysis Viral etiology of bronchiolitis among pediatric inpatients in northern Taiwan with emphasis on newly identified respiratory viruses Cloning of a human parvovirus by molecular screening of respiratory tract samples Human bocavirus infection in hospitalized children in Italy Human metapneumovirus and human bocavirus in children Sole pathogen in acute bronchiolitis: is there a role for other organisms apart from respiratory syncytial virus? Identifi cation of a new human coronavirus Characterization of human coronavirus OC43 and human coronavirus NL63 infections among hospitalized children <5 years of age Human coronavirus-NL63 infections in Korean children Infections by human coronavirus-NL in hospitalized children Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia Coronavirus HKU1 and other coronavirus infections in Hong Kong Coronavirus HKU1 in an Italian pre-term infant with bronchiolitis Pertussis and respiratory syncytial virus infections Bordetella pertussis infection is common in nonvaccinated infants admitted for bronchiolitis Atypical bacterial pathogen infection in children with acute bronchiolitis in northeast Thailand Clinical findings and severity of acute bronchiolitis Clinical predictors of admission in infants with acute bronchiolitis Frequency of apnea and respiratory viruses in infants with bronchiolitis Apnea in children hospitalized with bronchiolitis Incidence of apnea in infants hospitalized with respiratory syncytial virus bronchiolitis: a systematic review Outpatient assessment of infants with bronchiolitis Bronchiolitis: clinical characteristics associated with hospitalization and length of stay Association of fever and severe clinical course in bronchiolitis Utility of sepsis evaluation in infants 90 days of age or younger with fever and clinical bronchiolitis Occult serious bacterial infection in infants younger than 60 to 90 days with bronchiolitis: a systematic review A clinical scoring system for the diagnosis of respiratory failure. Several studies have attempted to investigate the correlation of bronchiolitis severity with the type of detected virus or viruses. keywords: bronchiolitis; children; disease; infants; rsv; severity; virus; wheezing cache: cord-283910-k10j5dzd.txt plain text: cord-283910-k10j5dzd.txt item: #208 of 427 id: cord-284266-tbndldhr author: Schippa, Serena title: Nasal Microbiota in RSV Bronchiolitis date: 2020-05-13 words: 5524 flesch: 29 summary: Our aim was to analyze the nasal microbiota from 48 infants affected by bronchiolitis from RSV virus and 28 infants with bronchiolitis but negative for the virus. Rosas et al. highlight that nasopharyngeal detection and increased abundance of the genus Lactobacillus during RSV infection in infancy is associated with a reduced risk of childhood wheezing illnesses at age 2 years keywords: abundance; bronchiolitis; group; infants; infection; microbial; microbiota; nasal; rsv; species; taxa; virus cache: cord-284266-tbndldhr.txt plain text: cord-284266-tbndldhr.txt item: #209 of 427 id: cord-284332-p4c1fneh author: Bosma, Karen J. title: Pharmacotherapy for Prevention and Treatment of Acute Respiratory Distress Syndrome: Current and Experimental Approaches date: 2012-09-19 words: 14538 flesch: 29 summary: The use of an inflammation-modulating diet in patients with acute lung injury or acute respiratory distress syndrome: a metaanalysis of outcome data Efficacy of an expanded ventilator bundle for the reduction of ventilatorassociated pneumonia in the medical intensive care unit Continuous aspiration of subglottic secretions in the prevention of ventilatorassociated pneumonia in the postoperative period of major heart surgery Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial Thromboprophylaxis in medicalsurgical critically ill patients Stress ulcer prophylaxis in critically ill patients: resolving discordant meta-analyses Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial Effects of physical training on functional status in patients with prolonged mechanical ventilation Recent trends in acute lung injury mortality: 1996-2005 Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis Effect of prone positioning in patients with acute respiratory distress syndrome: a metaanalysis Effect of mechanical ventilation in the prone position on clinical outcomes in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis1 Hemodynamic and gas exchange response to inhaled nitric oxide and prone positioning in acute respiratory distress syndrome patients High-frequency oscillatory ventilation in adults: the Toronto experience High-frequency oscillatory ventilation for adult patients with ARDS Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial Extracorporeal membrane oxygenation for 2009 influenza A (H1N1) acute respiratory distress syndrome Ketoconazole prevents acute respiratory failure in critically ill surgical patients A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome Development, implementation, and evaluation of a ketoconazole practice guideline for ARDS prophylaxis Angiotensin-converting enzyme inhibitor captopril prevents oleic acid-induced severe acute lung injury in rats Rosiglitazone attenuates the severity of sodium taurocholate-induced acute pancreatitis and pancreatitis-associated lung injury Chemically modified tetracycline prevents the development of septic shock and acute respiratory distress syndrome in a clinically applicable porcine model Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: meta-analysis Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: phase IIb, multicenter, randomized, placebo-controlled, clinical trial Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome: a randomized controlled trial The Beta-Agonist Lung Injury Trial (BALTI): a randomized placebo-controlled clinical trial Randomized, placebo-controlled trial of an aerosolized beta-2 adrenergic agonist (albuterol) for the treatment of acute lung injury Aerosolized surfactant in adults with sepsis-induced acute respiratory distress syndrome: Exosurf Acute Respiratory Distress Syndrome Sepsis Study Group Bovine surfactant therapy for patients with acute respiratory distress syndrome Venticute in patients with pneumonia or aspiration of gastric contents and intubation/ventilation/oxygenation impairment (BY2001/M1-007) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome The American-European Consensus Conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury Arachidonic acid remodeling in human inflammatory cells migrating to the lung in vivo Recent advances in genetic predisposition to clinical acute lung injury Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock Pharmacotherapy of acute lung injury and acute respiratory distress syndrome Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients? keywords: acute; ali; alveolar; ards; day; distress; group; injury; lung; mortality; neutrophil; patients; phase; results; risk; studies; study; surfactant; syndrome; treatment; trial; ventilation cache: cord-284332-p4c1fneh.txt plain text: cord-284332-p4c1fneh.txt item: #210 of 427 id: cord-284372-v95fzp8n author: Coyle, Peter V title: A touchdown nucleic acid amplification protocol as an alternative to culture backup for immunofluorescence in the routine diagnosis of acute viral respiratory tract infections date: 2004-10-25 words: 4719 flesch: 36 summary: key: cord-284372-v95fzp8n authors: Coyle, Peter V; Ong, Grace M; O'Neill, Hugh J; McCaughey, Conall; De Ornellas, Dennis; Mitchell, Frederick; Mitchell, Suzanne J; Feeney, Susan A; Wyatt, Dorothy E; Forde, Marian; Stockton, Joanne title: A touchdown nucleic acid amplification protocol as an alternative to culture backup for immunofluorescence in the routine diagnosis of acute viral respiratory tract infections date: 2004-10-25 journal: BMC Microbiol DOI: 10.1186/1471-2180-4-41 sha: doc_id: 284372 cord_uid: v95fzp8n BACKGROUND: Immunofluorescence and virus culture are the main methods used to diagnose acute respiratory virus infections. [3, 4] are the main methods used to diagnose acute respiratory virus infections. keywords: immunofluorescence; infections; influenza; parainfluenza; primer; specimens; strip; touchdown; type; virus; viruses cache: cord-284372-v95fzp8n.txt plain text: cord-284372-v95fzp8n.txt item: #211 of 427 id: cord-284858-hrljsc8l author: Cui, Shu-Juan title: Co-infection cases of human common respiratory viruses in Beijing, 2010–2012 date: 2013-02-27 words: 656 flesch: 44 summary: Dual infections by influenza A/H3N2 and B viruses and by influenza A/H3N2 and A/H1N1 viruses during winter 2007, Corsica Island Respiratory viral coinfection among hospitalized patients with H1N1 2009 during the first pandemic wave in Brazil Prevalence of human respiratory viruses in adults with acute respiratory tract infections in Beijing Childhood respiratory viruses in public health care centers Rate and influence of respiratory virus co-infection on pandemic (H1N1) influenza disease Xing-Huo Pang, Ying Deng * Multiple PCR diagnostic kit for simultaneously detecting 12 pathogens of respiratory viruses (Hangzhou Neuro-Hemin Biotech Co., Ltd., China) was used to confirm the pathogen. keywords: cases; viruses cache: cord-284858-hrljsc8l.txt plain text: cord-284858-hrljsc8l.txt item: #212 of 427 id: cord-284889-hth8nf5b author: Tsukagoshi, Hiroyuki title: Molecular epidemiology of respiratory viruses in virus-induced asthma date: 2013-09-12 words: 6964 flesch: 26 summary: Host-pathogen interactions that determine the severity of respiratory illnesses, and risk for subsequent asthma was increased by respiratory virus infection, especially due to RSV, in infants. Other previous reports suggested that the prevalence of RSV and HRV is similar (36 and 42%, respectively) in children less than 2 years of age, but differs (27 and 66%) in older children (Johnston et al., 1995; Grissell et al., 2005) . keywords: asthma; bronchiolitis; children; et al; hrv; human; infections; metapneumovirus; molecular; rhinovirus; rsv; severity; syncytial; virus; viruses; wheezing cache: cord-284889-hth8nf5b.txt plain text: cord-284889-hth8nf5b.txt item: #213 of 427 id: cord-284905-h8xovybl author: MUSK, A.W. (Bill) title: Respiratory infections and lung function in an Australian Aboriginal community date: 2008-02-05 words: 3450 flesch: 38 summary: key: cord-284905-h8xovybl authors: MUSK, A.W. (Bill); JAMES, Alan L.; PALMER, Lyle J.; RYAN, Gerard F.; LAKE, Fiona; GOLLEDGE, Clayton L.; De KLERK, Nicholas H. title: Respiratory infections and lung function in an Australian Aboriginal community date: 2008-02-05 journal: Respirology DOI: 10.1111/j.1440-1843.2007.01221.x sha: doc_id: 284905 cord_uid: h8xovybl Background and objective: To investigate the association between serological evidence of past infections with common respiratory pathogens and lung function in members of an isolated community of Aborigines from tropical coastal north‐western Australia. Cigarette smoking, poor nutrition, overcrowding and other adverse external conditions, including respiratory infections, may be responsible for these differences between Aboriginal and non-Aboriginal populations. keywords: age; community; function; infections; lung; smoking; study; titres cache: cord-284905-h8xovybl.txt plain text: cord-284905-h8xovybl.txt item: #214 of 427 id: cord-285096-g9y3au1a author: Mitchell, Judy A. title: Tropism and pathological findings associated with canine respiratory coronavirus (CRCoV) date: 2013-03-23 words: 7136 flesch: 44 summary: When studied in isolation dogs infected with other viruses involved in the CIRD complex, such as CPIV and CAV-2, also cause only mild respiratory disease such as a dry cough and nasal discharge (Appel and Binn, 1987a,b; Castleman, 1985; Buonavoglia and Martella, 2007) . Following experimental infection in dogs, all five CRCoV isolates gave rise to clinical signs of respiratory disease consistent with that observed during natural infection. keywords: canine; challenge; changes; coronavirus; crcov; day; disease; dogs; et al; infection; lung; study cache: cord-285096-g9y3au1a.txt plain text: cord-285096-g9y3au1a.txt item: #215 of 427 id: cord-285557-my16g91c author: Berger, A. title: Severe acute respiratory syndrome (SARS)—paradigm of an emerging viral infection date: 2004-01-31 words: 6386 flesch: 40 summary: Koch's postulates fulfilled for SARS virus Critically ill patients with severe acute respiratory syndrome SARS genome patent: symptom or disease? Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China Severe acute respiratory syndrome (SARS): breath-taking progress Electron microscopy for rapid diagnosis of infectious agents in emergent situations SARS coronavirus: a new challenge for prevention and therapy Clinical presentations and outcome of severe acute respiratory syndrome in children Hong Kong Department of Health. Hong Kong researchers reported at the WHO Global Conference on SARS in Kuala Lumpur in June 2003 that SARS patients treated with Kaletra (lopinavir with low-dose ritonavir) plus ribavirin experienced a 50% reduction in death rate. keywords: cases; coronavirus; cov; et al; health; human; organization; patients; sars; syndrome; transmission; world cache: cord-285557-my16g91c.txt plain text: cord-285557-my16g91c.txt item: #216 of 427 id: cord-285587-rggfg60a author: Meligy, Bassant title: Detection of viral acute lower respiratory tract infection in hospitalized infants using real-time PCR date: 2015-12-30 words: 3537 flesch: 45 summary: World Health Organization Factsheet no Comparison of Anyplex II RV16 with the xTAG respiratory viral panel and Seeplex RV15 for detection of respiratory viruses World Health Organization: the global burden of disease: 2004 update Comparison of multiplex PCR assays and conventional techniques for the diagnostic of respiratory virus infections in children admitted to hospital with an acute respiratory illness Evaluation of a novel real-time RT-PCR using TOCE technology compared with culture and Seeplex RV15 for simultaneous detection of respiratory viruses Narkevicˇi ut_ key: cord-285587-rggfg60a authors: Meligy, Bassant; Sayed, Amal; Ismail, Dalia Kadry; Kamal, Dina; Abdel-Latif, Walaa; Erfan, Dina M. title: Detection of viral acute lower respiratory tract infection in hospitalized infants using real-time PCR date: 2015-12-30 journal: Gaz Egypt Paediatr Assoc DOI: 10.1016/j.epag.2015.11.005 sha: doc_id: 285587 cord_uid: rggfg60a INTRODUCTION: keywords: cases; children; hospital; patients; pcr; study; virus; viruses cache: cord-285587-rggfg60a.txt plain text: cord-285587-rggfg60a.txt item: #217 of 427 id: cord-286337-qk90xb3a author: Hanada, Shigeo title: Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia date: 2018-11-16 words: 9815 flesch: 11 summary: The airway epithelium: soldier in the fight against respiratory viruses Influenza virus infection decreases tracheal mucociliary velocity and clearance of Streptococcus pneumoniae Ciliary dyskinesia is an early feature of respiratory syncytial virus infection Depression of monocyte and polymorphonuclear leukocyte oxidative metabolism and bactericidal capacity by influenza A virus Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection Both influenza-induced neutrophil dysfunction and neutrophil-independent mechanisms contribute to increased susceptibility to a secondary Streptococcus pneumoniae infection Influenza virus-induced immune complexes suppress alveolar macrophage phagocytosis Alteration of pulmonary macrophage function by respiratory syncytial virus infection in vitro Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections Immune impairment of alveolar macrophage phagocytosis during influenza virus pneumonia Effect of virus infection on the inflammatory response. The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial Probiotics for the prevention of respiratory tract infections: a systematic review The microbial metabolite desaminotyrosine protects from influenza through type I interferon Oral administration of heat-killed Lactobacillus plantarum L-137 enhances protection against influenza virus infection by stimulation of type I interferon production in mice Augmentation of cellular immunity and reduction of influenza virus titer in aged mice fed Lactobacillus casei strain Shirota Microbiota regulates the TLR7 signaling pathway against respiratory tract influenza keywords: bacterial; changes; colonization; gut; host; infection; influenza; mice; microbial; microbiome; patients; pneumoniae; respiratory; responses; streptococcus; tract; virus cache: cord-286337-qk90xb3a.txt plain text: cord-286337-qk90xb3a.txt item: #218 of 427 id: cord-286443-t0asknzu author: Emerson, Julia title: Home Self-Collection of Nasal Swabs for Diagnosis of Acute Respiratory Virus Infections in Children With Cystic Fibrosis date: 2013-07-14 words: 4010 flesch: 39 summary: Severe viral respiratory infections in infants with cystic fibrosis Respiratory viruses in children with cystic fibrosis: viral detection and clinical findings Effects of upper respiratory tract infections in patients with cystic fibrosis Effects of viral lower respiratory tract infection on lung function in infants with cystic fibrosis Effect of respiratory virus infections including rhinovirus on clinical status in cystic fibrosis Prevalence and impact of respiratory viral infections in young children with cystic fibrosis: prospective cohort study Association of respiratory viral infections with pulmonary deterioration in patients with cystic fibrosis The role of respiratory viruses in cystic fibrosis Importance of viruses and Legionella pneumophila in respiratory exacerbations of young adults with cystic fibrosis The effect of respiratory viral infections on patients with cystic fibrosis Influenza-associated cystic fibrosis pulmonary exacerbations Rhinovirus C and respiratory exacerbations in children with cystic fibrosis Role of respiratory viruses in pulmonary exacerbations in children with cystic fibrosis Detection of viral and bacterial respiratory pathogens in patients with cystic fibrosis Comparing nosethroat swabs and nasopharyngeal aspirates collected from children with symptoms for respiratory virus identification using real-time polymerase chain reaction Detection of multiple respiratory pathogens during primary respiratory infection: nasal swab versus nasopharyngeal aspirate using real-time polymerase chain reaction Comparative study of nasopharyngeal aspirate and nasal swab specimens for diagnosis of acute viral respiratory infection Non-invasive sample collection for respiratory virus testing by multiplex PCR E-mail-based symptomatic surveillance combined with self-collection of nasal swabs: a new tool for acute respiratory infection epidemiology Monitoring the emergence of community transmission of influenza A/H1N1 2009 in England: a cross sectional opportunistic survey of self sampled telephone callers to NHS Direct Collection by trained pediatricians or parents of mid-turbinate nasal flocked swabs for the detection of influenza viruses in childhood Community epidemiology of human metapneumovirus, human coronavirus NL63, and other respiratory viruses in healthy preschool-aged children using parent-collected specimens Parent-collected respiratory specimens-a novel method for respiratory virus and vaccine efficacy research Self-collected midturbinate swabs for the detection of respiratory viruses in adults with acute respiratory illnesses Self-collection of foam nasal swabs for respiratory virus detection by pcr among immunocompetent subjects and hematopoietic cell transplant recipients Clinical disease in children associated with newly described coronavirus subtypes Detection and quantification of human metapneumovirus in pediatric specimens by real-time RT-PCR Comparison of realtime PCR assays with fluorescent-antibody assays for diagnosis of respiratory virus infections in children Evaluation of quantitative and type-specific real-time RT-PCR assays for detection of respiratory syncytial virus in respiratory specimens from children Real-time reverse transcription-PCR assay for comprehensive detection of human rhinoviruses Respiratory virus infection among hematopoietic cell transplant recipients: evidence for asymptomatic parainfluenza virus infection Linking syndromic surveillance with virological self-sampling Self-Collection of Nasal Swabs for Viral Diagnosis in Cystic Fibrosis 351 Home self-collection is feasible and well tolerated for timely respiratory virus diagnosis and provides a novel approach for clinical diagnostics and surveillance of respiratory virus infections among CF patients. keywords: clinic; collection; foam; home; nasal; swabs; virus cache: cord-286443-t0asknzu.txt plain text: cord-286443-t0asknzu.txt item: #219 of 427 id: cord-286449-ekvzaae2 author: McManus, Terence E. title: Respiratory viral infection in exacerbations of COPD date: 2008-07-30 words: 3109 flesch: 46 summary: key: cord-286449-ekvzaae2 authors: McManus, Terence E.; Marley, Anne-Marie; Baxter, Noreen; Christie, Sharon N.; O'Neill, Hugh J.; Elborn, J. Stuart; Coyle, Peter V.; Kidney, Joseph C. title: Respiratory viral infection in exacerbations of COPD date: 2008-07-30 journal: The role of respiratory viral infection is just emerging. keywords: copd; disease; exacerbations; infection; patients; study; viruses cache: cord-286449-ekvzaae2.txt plain text: cord-286449-ekvzaae2.txt item: #220 of 427 id: cord-286472-pqtem19t author: McFee, R.B. title: MIDDLE EAST RESPIRATORY SYNDROME (MERS) CORONAVIRUS date: 2020-07-28 words: 5367 flesch: 40 summary: Of note, co-infection with other respiratory viruses and a few cases of co-infection with communityacquired bacteria at admission has been reported in MERS CoV patients. Patients recently returning from the Middle East, presenting with significant respiratory illness, with CT findings of peribronchial region abnormalities, organizing pneumonia, should be considered for MERS CoV infection, and if possible, queried about international travel and occupational exposures. keywords: cases; coronavirus; cov; east; infection; mers; middle; patients; sars; serum; specimen; syndrome; testing; treatment cache: cord-286472-pqtem19t.txt plain text: cord-286472-pqtem19t.txt item: #221 of 427 id: cord-286602-cdueeg47 author: Petsonk, Edward L. title: Respiratory protection for health care workers: A 2020 COVID‐19 perspective date: 2020-06-04 words: 1768 flesch: 31 summary: Effective respiratory protection for HCWs is particularly critical for emerging diseases such as COVID-19, with high case fatality rates, and before modes of transmission are adequately defined and vaccines or effective treatments are available. Respiratory protection programs (see Table 1 ) offer users specific skills and knowledge, as well as the technical support essential for successful protection. keywords: care; hcws; health; n95; protection; respirators cache: cord-286602-cdueeg47.txt plain text: cord-286602-cdueeg47.txt item: #222 of 427 id: cord-286924-zk7hzcla author: Haytoğlu, Zeliha title: Bocavirus Viremia and Hepatitis in an Immunocompetent Child date: 2017-05-15 words: 1534 flesch: 45 summary: The clinical manifestatons of HBoV respiratory tract infection have ranged from mild upper respiratory disease (3, 4) to severe life-threatening pneumonia (2, 5) . HBoV infections are frequently detected in <2-year-old children often with other respiratory viruses (3, 4) . keywords: bocavirus; hbov; hepatitis; infection cache: cord-286924-zk7hzcla.txt plain text: cord-286924-zk7hzcla.txt item: #223 of 427 id: cord-286930-c1zkjdgf author: Park, Won-Ju title: Seroprevalence of Respiratory Syncytial Virus IgG among Healthy Young Adults in Basic Training for the Republic of Korea Air Force date: 2014-09-02 words: 1578 flesch: 41 summary: In an effort to prevent respiratory infections in the military, further RSV studies and challenges regarding diagnosis of RSV infection would be necessary. Respiratory diseases among U.S. military personnel: countering emerging threats Respiratory syncytial virus: an important cause of acute respiratory illness among young adults undergoing military training Symptomatic respiratory syncytial virus infection in previously healthy young adults living in a crowded military environment Medical microvirology Epidemiology of respiratory viral infection using multiplex rt-PCR in Clinical and epidemiological comparison of human metapneumovirus and respiratory syncytial virus in seoul Respiratory syncytial virus and parainfluenza virus Serosurvey of bacterial and viral respiratory pathogens among deployed U.S. service members Seroprevalence of anti-RSV IgG in Thai children aged 6 months to 5 years Large-scale seroprevalence analysis of human metapneumovirus and human respiratory syncytial virus infections in Beijing Protective and disease-enhancing immune responses to respiratory syncytial virus Relationship of serum antibody to risk of respiratory syncytial virus infection in elderly adults Role of neutralizing antibodies in adults with community-acquired pneumonia by respiratory syncytial virus The level and duration of RSV-specific maternal IgG in infants in Kilifi Kenya Prevalence of respiratory syncytial virus IgG antibodies in infants living in a rural area of Mozambique Adults 65 years old and older have reduced numbers of functional memory T cells to respiratory syncytial virus fusion protein Epidemiological characterization of respiratory viruses detected from acute respiratory patients in Seoul Respiratory syncytial virus infection in adult populations Risk factors for respiratory syncytial virus illness among patients with chronic obstructive pulmonary disease keywords: igg; infection; rsv; virus cache: cord-286930-c1zkjdgf.txt plain text: cord-286930-c1zkjdgf.txt item: #224 of 427 id: cord-287156-3plpi6i9 author: Lassandro, Giuseppe title: Children in Coronaviruses’ Wonderland: What Clinicians Need to Know date: 2020-07-01 words: 8034 flesch: 36 summary: Multisystem Inflammatory Syndrome in Children in COVID-19-associated immune thrombocytopenia Immune Thrombocytopenia (ITP) in a SARS-CoV-2 Positive Pediatric Patient Covid-19 and Children with Immune Thrombocytopenia: Emerging Issues Evans syndrome in a patient with COVID-19 COVID-19 infection associated with autoimmune hemolytic anemia Chest computed tomography in children with COVID-19 respiratory infection Clinical and CT imaging features of the COVID-19 pneumonia: Influenza Other Respir Viruses Epidemiology characteristics of human coronaviruses in patients with respiratory infection symptoms and phylogenetic analysis of HCoV-OC43 during 2010-2015 in Guangzhou Human Coronavirus Infections in Israel: Epidemiology, Clinical Symptoms and Summer Seasonality of HCoV-HKU1. keywords: acute; cases; children; clinical; coronavirus; covid-19; disease; east; human; infection; mers; middle; novel; patients; sars; symptoms; syndrome cache: cord-287156-3plpi6i9.txt plain text: cord-287156-3plpi6i9.txt item: #225 of 427 id: cord-287178-hu6vlc9u author: Wong-Chew, Rosa M title: Prevalence of respiratory virus in symptomatic children in private physician office settings in five communities of the state of Veracruz, Mexico date: 2015-06-25 words: 2799 flesch: 39 summary: In: WLCiP D (ed) Global health indicators Dirección general de Epidemiología Detection of respiratory viruses by molecular methods Global initiative for asthma Seasonality of viral infections: mechanisms and unknowns Epidemiology and seasonality of respiratory viral infections in hospitalized children in Kuala Lumpur, Malaysia: a retrospective study of 27 years Infecciones respiratorias agudas (IRAS) de etiologia viral en México Viral etiology of lower respiratory tract infections in hospitalized children in Mexico Frequency of respiratory viruses and clinical characteristics in children attending a care center in Mexico City Frequency of viruses associated with acute respiratory infections in children younger than five years of age at a locality of Mexico City Comparative viral frequency in Mexican children under 5 years of age with and without upper respiratory symptoms Human metapneumovirus infections in Mexico: epidemiological and clinical characteristics Agentes etiológicos de bronquiolitis en niños Impact of respiratory syncytial virus on hospital admissions in children younger than 3 years of age Epidemiology of viral respiratory infections in a tertiary care centre in the era of molecular diagnosis La Res ILI002 Study Group: clinical characteristics and outcomes of influenza and other influenza-like illnesses in Mexico City Human metapneumovirus in children with influenza-like illness in Yucatan, Mexico Multiple simultaneous viral infections in infants with acute respiratory tract infections in Spain Viral etiology of acute respiratory tract infections in children presenting to hospital: role of polymerase chain reaction and demonstration of multiple infections Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • The aim of this study was to evaluate the diversity of respiratory viruses in the community setting using molecular diagnostic tools, as well as the clinical characteristics of respiratory viral infections in the general pediatric practice in Mexico. keywords: children; infections; mexico; study; tract; viruses cache: cord-287178-hu6vlc9u.txt plain text: cord-287178-hu6vlc9u.txt item: #226 of 427 id: cord-289050-9w7ks01n author: Donoso, Alejandro F. title: Fatal hemorrhagic pneumonia caused by human metapneumovirus in an immunocompetent child date: 2008-08-25 words: 1783 flesch: 43 summary: This agent causes acute respiratory tract infections in children and adults. Although the spectrum of clinical manifestations of hMPV infection is not completely defi ned as yet, the most frequent manifestations include cough, coryza and pharyngitis. keywords: children; hmpv; human; metapneumovirus; patient; respiratory cache: cord-289050-9w7ks01n.txt plain text: cord-289050-9w7ks01n.txt item: #227 of 427 id: cord-289139-5ljqnc39 author: Mengelle, C. title: The use of a multiplex real-time PCR assay for diagnosing acute respiratory viral infections in children attending an emergency unit date: 2014-09-03 words: 2574 flesch: 47 summary: respiratory viral panel with in-house nucleic acid amplification tests for diagnosis of respiratory virus infections Epidemiology of viral respiratory tract infections in a prospective cohort of infants and toddlers attending daycare Multiple versus single virus respiratory infections: viral load and clinical disease severity in hospitalized children Severe lower respiratory tract infection in infants and toddlers from a nonaffluent population: viral etiology and co-detection as risk factors Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis Single versus dual respiratory virus infections in hospitalized infants: impact on clinical course of disease and interferon-gamma response The 2009 pandemic influenza A(H1N1) coincides with changes in the epidemiology of other viral pathogens causing acute respiratory tract infections in children Rates of hospitalisation for influenza, respiratory syncytial virus and human metapneumovirus among infants and young children Spectrum and frequency of illness presenting to a pediatric emergency department Relative quantification of 40 nucleic acid sequences by multiplex ligationdependent probe amplification Performance of a rapid molecular multiplex assay for the detection of influenza and picornaviruses Pathogen chip for respiratory tract infections A Prospective Study of Agents associated with acute respiratory infection among young American Indian children Comparison of multiplex PCR assays and conventional techniques for the diagnostic of respiratory virus infections in children admitted to hospital with an acute respiratory illness Viral etiology of common cold in children Prospective evaluation of a novel multiplex real-time PCR assay for detection of fifteen respiratory pathogens-duration of symptoms significantly affects detection rate Do rhinoviruses cause pneumonia in children? Lower respiratory tract infections associated with rhinovirus during infancy and increased risk of wheezing during childhood. keywords: children; infections; samples; symptoms; viruses cache: cord-289139-5ljqnc39.txt plain text: cord-289139-5ljqnc39.txt item: #228 of 427 id: cord-289282-4oz6r7op author: Hon, Kam Lun title: Overview: The history and pediatric perspectives of severe acute respiratory syndromes: Novel or just like SARS date: 2020-06-01 words: 3561 flesch: 51 summary: Summary of probable SARS cases with onset of illness from The SARS epidemic in Hong Kong Laboratory diagnosis of SARS Severe acute respiratory syndrome (SARS): Development of diagnostics and antivirals Severe acute respiratory syndrome in children Clinical presentations and outcome of severe acute respiratory syndrome in children Severe acute respiratory syndrome among children Severe acute respiratory syndrome in children: Experience in a regional hospital in Hong Kong IpPL-S. Osteonecrosis in children with severe acute respiratory syndrome Clinical features, diagnosis, treatment and short-term outcome of severe acute respiratory syndrome (SARS) in children Severe acute respiratory syndrome (SARS) in children: epidemiology, presentation and management Childhood SARS in Hong Kong Middle East respiratory syndrome World Health Organization. 19 Follow-up of SARS patients at 6 months after the illness only showed mild residual changes in exercise tolerance and pulmonary function. keywords: cases; children; coronavirus; covid-19; novel; patients; sars; symptoms; syndrome cache: cord-289282-4oz6r7op.txt plain text: cord-289282-4oz6r7op.txt item: #229 of 427 id: cord-289697-g24xib4l author: MacDowell, Ana L. title: Infectious triggers of asthma date: 2005-03-01 words: 7780 flesch: 33 summary: Serum IgE levels in white and metis communities in Saskatchewan Hay fever, hygiene, and household size Viral induction of a chronic asthma phenotype and genetic segregation from the acute response Recurrent wheezy bronchitis and viral respiratory infections Viral respiratory infections in asthamtic children staying in a mountain resort Microbiology and epidemiology of upper respiratory tract infections Acute respiratory illness in the community: frequency of illness and the agents involved Repeat consultations after antibiotic prescribing for respiratory infection: a study in one general practice The economic burden of non-influenza-related viral respiratory tract infection in the United States Risk factors for lower respiratory complications of rhinovirus infections in elderly people living in the community: prospective cohort study Community study of role of viral infections in exacerbations of asthma in 9-11 year old children Viral respiratory tract infections and exacerbations of asthma in adult patients Viruses as precipitants of asthma symptoms. Viral infections commonly trigger asthma exacerbations, having been noted in nearly half of asthma exacerbations in adults [10] and in an even greater percentage of exacerbations in children. keywords: acute; age; asthma; children; exacerbations; infection; influenza; patients; pneumoniae; rsv; study; virus; wheezing cache: cord-289697-g24xib4l.txt plain text: cord-289697-g24xib4l.txt item: #230 of 427 id: cord-290505-omszep7u author: Pochon, Cécile title: Respiratory Virus Infections in Hematopoietic Cell Transplant Recipients date: 2019-01-09 words: 12166 flesch: 27 summary: That said, CMV is a pathogen that frequently occurs as part of a simultaneous infection -indeed a respiratory viral infection can often precede bacterial and fungal infections -thus further complications associated with respiratory virus infections need to be acknowledged. In this review, we will focus on respiratory virus infections and, particularly, those that are commonly detected after HCT. keywords: cell; cell transplant; disease; et al; hct; human; infections; lri; mortality; patients; piv; progression; recipients; respiratory; risk; rsv; stem; study; transplant; transplantation; treatment; virus cache: cord-290505-omszep7u.txt plain text: cord-290505-omszep7u.txt item: #231 of 427 id: cord-291217-fpte1q9m author: Adams, Madeleine title: Management of bronchiolitis date: 2009-05-13 words: 3537 flesch: 29 summary: For higher concentrations, a combination of head box and facemask or rebreathing bag may be used, although this usually implies significant respiratory failure and often precedes respiratory collapse. Intravenous RSV immune globulin is ineffective in the acute treatment of RSV lower respiratory tract infection. keywords: benefit; bronchiolitis; children; hospitalization; infants; rsv; ventilation cache: cord-291217-fpte1q9m.txt plain text: cord-291217-fpte1q9m.txt item: #232 of 427 id: cord-291618-166wvdbt author: Mikulska, Małgorzata title: Epidemiology of viral respiratory tract infections in an outpatient haematology facility date: 2013-10-06 words: 4045 flesch: 31 summary: Emerging viral infections after hematopoietic cell transplantation Community respiratory virus infections in immunocompromised patients: hematopoietic stem cell and solid organ transplant recipients, and individuals with human immunodeficiency virus infection Respiratory virus infections in stem cell transplant patients: the European experience Respiratory virus infections after marrow transplant: the Fred Hutchinson Cancer Research Center experience Prospective study of the incidence, clinical features, and outcome of symptomatic upper and lower respiratory tract infections by respiratory viruses in adult recipients of hematopoietic stem cell transplants for hematologic malignancies The challenge of respiratory virus infections in hematopoietic cell transplant recipients Respiratory syncytial virus pneumonitis in immunocompromised adults: clinical features and outcome Airflow decline after myeloablative allogeneic hematopoietic cell transplantation: the role of community respiratory viruses Strong association between respiratory viral infection early after hematopoietic stem cell transplantation and the development of life-threatening acute and chronic alloimmune lung syndromes Nucleic acid amplification-based diagnosis of respiratory virus infections Rapid virological surveillance of community influenza infection in general practice Changing epidemiology of respiratory viral infections in hematopoietic cell transplant recipients and solid organ transplant recipients Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major cancer center Persistent symptomless human metapneumovirus infection in hematopoietic stem cell transplant recipients Respiratory syncytial virus infection in patients with hematological diseases: single-center study and review of the literature Outcome of influenza infections in outpatients after allogeneic hematopoietic stem cell transplantation Respiratory virus infection in immunocompromised patients Community-acquired respiratory syncytial virus and parainfluenza virus infections after hematopoietic stem cell transplantation: the Fred Hutchinson Cancer Research Center experience Management of RSV infections in adult recipients of hematopoietic stem cell transplantation Respiratory virus infection among hematopoietic cell transplant recipients: evidence for asymptomatic parainfluenza virus infection Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective Safety and tolerability of oseltamivir prophylaxis in hematopoietic stem cell transplant recipients: a retrospective casecontrol study Viral disease prevention after hematopoietic cell transplantation Manual for the laboratory diagnosis and virological surveillance of influenza ECIL-4): guidelines for diagnosis and treatment of human respiratory syncytial virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus Rapid detection and identification of 12 respiratory viruses using a dual priming oligonucleotide systembased multiplex PCR assay Vaccination of hematopoietic cell transplant recipients Predicting influenza infections during epidemics with use of a clinical case definition Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP) For influenza infection, the management strategy based on the presence of influenza-like illness syndrome (ILI) has been successfully used in epidemiological and treatment studies in immunocompetent patients. keywords: cell; infection; influenza; patients; rsv; symptoms; virus; vrti cache: cord-291618-166wvdbt.txt plain text: cord-291618-166wvdbt.txt item: #233 of 427 id: cord-291639-hioh2s35 author: Alfredo, Potena title: Pathophysiology of viral-induced exacerbations of COPD date: 2007-12-17 words: 4436 flesch: 22 summary: Granulocyte infl ammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease Recognition of doublestranded RNA and activation of NF-kappaB by Toll-like receptor 3 Respiratory syncytial virus infection of human lung endothelial cells enhances selectively intercellular adhesion molecule-1 expression Respiratory syncytial virus infection of human primary nasal and bronchial epithelial cell cultures and bronchoalveolar macrophages Airway epithelial cell-induced activation of monocytes and eosinophils in respiratory syncytial viral infection Respiratory viral infections in patients with chronic, obstructive pulmonary disease Blocking intercellular adhesion molecule-1 on human epithelial cells decreases respiratory syncytial virus infection Transcription factors in asthma and COPD Molecular mechanisms of respiratory virus-induced asthma and COPD exacerbations and pneumonia Requirement of a novel upstream response element in respiratory syncytial virus-induced IL-8 gene expression Activation of ERK2 by respiratory syncytial virus in A549 cells is linked to the production of interleukin 8 Respiratory syncytial virus infl uences NF-kappaB-dependent gene expression through a novel pathway involving MAP3K14/NIK expression and nuclear complex formation with NF-kappaB2 Role of defi cient type III interferon-lambda production in asthma exacerbations Effectiveness of neuraminidase inhibitors in treatment and prevention of infl uenza A and B: systematic review and meta-analyses of randomised controlled trials Respiratory syncytial virus infection of monocyte-derived dendritic cells decreases their capacity to activate CD4 T cells Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease Detection of respiratory syncytial virus and human metapneumovirus by reverse transcription polymerase chain reaction in adults with and without respiratory illness Respiratory syncytial virus infection in elderly and high-risk adults Respiratory syncytial virus infection in adults Inhibition of viral replication reverses respiratory syncytial virus-induced NF-kappaB activation and interleukin-8 gene expression in A549 cells Lower airways infl ammation during rhinovirus colds in normal and in asthmatic subjects Relationship of upper and lower airway cytokines to outcome of experimental rhinovirus infection Global Initiative for Chronic Obstructive Lung Disease, National Institute of Health, National Heart Lung, and Blood Institute. In this review we will provide an overview of the relationship between respiratory virus infection and the molecular mechanisms involved in the activation of airway infl ammation in COPD exacerbations. keywords: cells; copd; disease; exacerbations; infection; infl; rhinovirus; virus cache: cord-291639-hioh2s35.txt plain text: cord-291639-hioh2s35.txt item: #234 of 427 id: cord-291961-usl8z6ep author: Zheng, Wen-zhi title: Human polyomavirus type six in respiratory samples from hospitalized children with respiratory tract infections in Beijing, China date: 2015-10-13 words: 2937 flesch: 50 summary: The full-length HPyV6 sequence was aligned with the sequences of other HPyVs and other HPyV6 strains available in GenBank with DNAStar software. All 15 HPyV6-positive patients were coinfected with other respiratory viruses, of which influenza virus A (IFVA) (8/15, 53.3 %) and respiratory syncytial virus (7/15, 46.7 %) were most common. keywords: children; genome; hpyv6; patients; pcr; polyomavirus; time cache: cord-291961-usl8z6ep.txt plain text: cord-291961-usl8z6ep.txt item: #235 of 427 id: cord-292261-gh9cifjr author: Feng, Fan title: Qigong for the Prevention, Treatment, and Rehabilitation of COVID-19 Infection in Older Adults date: 2020-05-15 words: 2953 flesch: 35 summary: [State Administration of Traditional Medicine of China Web site Dysregulation of immune response in patients with COVID-19 in Pulmonary rehabilitation guidelines in the principle of 4S for patients infected with 2019 novel coronavirus (2019•nCoV) Foundation theory of Traditional Chinese medicine China press of Traditional Chinese medicine Effect of meditative movement on affect and flow in Qigong practitioners Physical and psychological health outcomes of Qigong exercise in older adults: a systematic review and meta-analysis The beneficial effects of Qigong on elderly depression The Effect of continuous fitness Qigong exercise on mild cognitive impairment in the elderly Daily mindful responding mediates the effect of meditation practice on stress and mood the role of practice duration and adherence Relaxation response Acute effect of qigong training on stress hormonal levels in man Qigong and Tai-Chi for mood regulation Effect of Qigong on self-rating depression and anxiety scale scores of COPD patients: A meta-analysis Qigong practice among chronically ill patients during the SARS outbreak Coping with future epidemics: Taichi practice as an overcoming strategy used by survivors of severe acute respiratory syndrome (SARS) in post-SARS Hong Kong The Effect of Qigong on muscle function of older adults Effect of different breathing training methods on the fatigue and diaphragm muscle function of stroke patients Effectiveness of water-based Liuzijue exercise on respiratory muscle strength and peripheral skeletal muscle function in patients with COPD Mitigating cellular inflammation in older adults: a randomized controlled trial of TaiChi Chih Cognitive behavioral therapy and TaiChi reverse cellular and genomic markers of inflammation in late-life insomnia: a randomized controlled trial Regular Taichi chuan exercise enhances functional mobility and CD4CD25 regulatory T cells Effect of six-word breath exercise on the inflammatory immune factors and pathogen distribution in asthma patients Study on anti-aging effect of Qigong Baduanjin Effects of exercising building-up Qigong-Wuqinxi on middle-aged and old people' s NK cell activity Upper respiratory tract infection, and the immune system TaiChi Chuan increases circulating myeloid dendritic cells Acute effects on the counts of innate and adaptive immune response cells after 1 month of Taoist Qigong practice Effect of TaiChi exercise on antioxidant enzymes activities and immunity function in middle-aged participants Augmenting immune responses to varicella zoster virus in older adults: a randomized, controlled trial of TaiChi Effects of a Taiji and Qigong intervention on the antibody response to influenza vaccine in older adults Effect of Qigong on the prevention and treatment of respiratory tract infection in the Elderly A pilot study of Qigong practice and upper respiratory illness in elite swimmers Research On the Impact of the Taichi Chuan or the upper respiratory tract infection for female students The therapeutic effects of qigong in patients with chronic obstructive pulmonary disease in the stable stage: a meta-analysis Effects of long-term home-based Liuzijue exercise combined with clinical guidance in elderly patients with chronic obstructive pulmonary disease Effect of BaDuanJin on respiratory symptoms in chronic bronchitis Abdominal breathing increases tear secretion in healthy women Ba Duan Jin --an ancient Chinese exercise Effects of Qigong exercise on non-motor symptoms and inflammatory status in parkinson's disease: a protocol for a randomized controlled trial Pursed-lips breathing reduces dynamic hyperinflation induced by activities of daily living test in patients with chronic obstructive pulmonary disease: A randomized cross-over study Focal vibration in neurorehabilitation Vibrational therapies for vocal fatigue Many studies on Qigong have been carried out through modern research methods, including the observation of physiological and psychological changes during or after Qigong practice, along with clinical trials of treating various diseases with Qigong. keywords: body; breathing; covid-19; function; infection; movement; practice; qigong cache: cord-292261-gh9cifjr.txt plain text: cord-292261-gh9cifjr.txt item: #236 of 427 id: cord-292587-hp4zd8lr author: Rubino, Ilaria title: Respiratory Protection against Pandemic and Epidemic Diseases date: 2017-10-31 words: 2611 flesch: 30 summary: Therefore, respiratory protection devices are a key non-pharmaceutical intervention that is essential to the global strategy for pandemic readiness. Safer and More Effective Respiratory Protection for a Timely Emergency Response? Diverse methods have been investigated to improve the performance of respiratory protection devices (Box 1), such as higher subject releases pathogenic aerosols by breathing, talking, sneezing, and coughing. keywords: devices; efficiency; filtration; infection; masks; pandemic; protection; respirators cache: cord-292587-hp4zd8lr.txt plain text: cord-292587-hp4zd8lr.txt item: #237 of 427 id: cord-292828-29jbf9ik author: Alsaleh, Asma N title: Nasal swab samples and real-time polymerase chain reaction assays in community-based, longitudinal studies of respiratory viruses: the importance of sample integrity and quality control date: 2014-01-09 words: 3920 flesch: 39 summary: Such studies do however have some logistical challenges, particularly concerning respiratory sample collection and transport. The EHV1 component was performed as an extraction and inhibitor control as described previously [24] , while ERV3 was used as a marker to evaluate the quality of nasal swab sample collection [25] . keywords: detection; erv3; human; mould; nasal; samples; study; swab; time; virus cache: cord-292828-29jbf9ik.txt plain text: cord-292828-29jbf9ik.txt item: #238 of 427 id: cord-292836-1o2ynvy3 author: Ogimi, Chikara title: What’s New With the Old Coronaviruses? date: 2020-04-21 words: 5200 flesch: 41 summary: Frequency of and relationship between outbreaks of coronavirus infection Epidemiology of viral respiratory tract infections in a prospective cohort of infants and toddlers attending daycare Epidemiology of multiple respiratory viruses in childcare attendees Community surveillance of respiratory viruses among families in the Utah Better Identification of Germs-Longitudinal Viral Epidemiology (BIG-LoVE) study Seroepidemiologic survey of coronavirus (strain 229E) infections in a population of children Severity and outcome associated with human coronavirus OC43 infections among children New Vaccine Surveillance Network. Human coronavirus in young children hospitalized for acute respiratory illness and asymptomatic controls Community study of role of viral infections in exacerbations of asthma in 9-11 year old children The pediatric burden of human coronaviruses evaluated for twenty years Coronavirus-associated pneumonia in previously healthy children Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, China Epidemiology and clinical features of human coronaviruses in the pediatric population Characteristics and outcomes of coronavirus infection in children: the role of viral factors and an immunocompromised state Genetic variability of human coronavirus OC43-, 229E-, and NL63-like strains and their association with lower respiratory tract infections of hospitalized infants and immunocompromised patients Detection of rhinovirus, respiratory syncytial virus, and coronavirus infections in acute otitis media by reverse transcriptase polymerase chain reaction Viral upper respiratory tract infection and otitis media complication in young children Croup is associated with the novel coronavirus NL63 Role of human coronavirus NL63 in hospitalized children with croup Human coronavirus OC43 pneumonia in a pediatric cancer patient with Down syndrome and acute lymphoblastic leukemia Fatal respiratory distress syndrome due to coronavirus infection in a child with severe combined immunodeficiency Coronavirus 229E-related pneumonia in immunocompromised patients Fatal lower respiratory tract disease with human corona virus NL63 in an adult haematopoietic cell transplant recipient A multicenter consortium to define the epidemiology and outcomes of inpatient respiratory viral infections in pediatric hematopoietic stem cell transplant recipients Clinical significance of human coronavirus in bronchoalveolar lavage samples from hematopoietic cell transplant recipients and patients with hematologic malignancies Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients Prolonged shedding of human coronavirus in hematopoietic cell transplant recipients: risk factors and viral genome evolution Parallel evolution of influenza across multiple spatiotemporal scales Detection of human coronaviruses in children with acute gastroenteritis Detection of human coronaviruses in simultaneously collected stool samples and nasopharyngeal swabs from hospitalized children with acute gastroenteritis Human coronavirus OC43 associated with fatal encephalitis Detection of coronavirus in the central nervous system of a child with acute disseminated encephalomyelitis The role of human coronaviruses in children hospitalized for acute bronchiolitis, acute gastroenteritis, and febrile seizures: a 2-year prospective study Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system? Canadian Severe Acute Respiratory Syndrome Study Team. keywords: children; coronavirus; hcov; human; infection; patients; sars; study; syndrome; viruses cache: cord-292836-1o2ynvy3.txt plain text: cord-292836-1o2ynvy3.txt item: #239 of 427 id: cord-292871-vgposxom author: Falsey, Ann R. title: The “Common Cold” in Frail Older Persons: Impact of Rhinovirus and Coronavirus in a Senior Daycare Center date: 2015-04-27 words: 3424 flesch: 47 summary: The Tecumseh study Acute respiratory tract infections in daycare centers for older persons Viral respiratory infections in the institutionalized elderly: Clinical and epidemiologic findings A rhinovirus outbreak among residents of a long-term care facility Principles and Practices of Infectious Diseases Impact of respiratory virus infection in patients with chronic chest disease Association of viral and mycoplasma pneumoniae infections with acute respiratory illness in patients with chronic obstructive pulmonary diseases Viruses as precipitants of asthmatic attacks in children Respiratory syncytial virus and influenza A infections in the hospitalized elderly Parainfluenza outbreaks in extended-care facilities -United States Excess pneumonia and influenza hospitalization in the US due 26 Epidemiology and control of nosocomial virus infec Hand-to-hand transmission of to infmenza epidcmics, 1970-78 726. Thirty-five (7%) of 522 cultures were positive for rhinovirus and 37 (8%) of 451 serologies were positive for coronavirus 229E infection. keywords: coronavirus; daycare; illnesses; infections; persons; respiratory; rhinovirus cache: cord-292871-vgposxom.txt plain text: cord-292871-vgposxom.txt item: #240 of 427 id: cord-293354-55nawxos author: Kenmoe, Sebastien title: Viral etiology of severe acute respiratory infections in hospitalized children in Cameroon, 2011–2013 date: 2016-05-09 words: 3719 flesch: 43 summary: The role of respiratory viral infections among children hospitalized for community-acquired pneumonia in a developing country Respiratory viruses from hospitalized children with severe pneumonia in the Philippines Respiratory viruses in hospitalized children with influenza-like illness during the H1n1 Frequent detection of viral coinfection in children hospitalized with acute respiratory tract infection using a real-time polymerase chain reaction Viral pathogens associated with acute respiratory infections in central vietnamese children Respiratory viruses in children hospitalized for acute lower respiratory tract infection in Ghana Epidemiology and seasonality of respiratory viral infections in hospitalized children in Kuala Lumpur, Malaysia: a retrospective study of 27 years Viral etiology and clinical profiles of children with severe acute respiratory infections in China Viral respiratory infections in hospitalized and community control children in Alaska Broad respiratory virus detection in infants hospitalized for bronchiolitis by use of a multiplex RT-PCR DNA microarray system Human bocavirus and other respiratory viral infections in a 2-year cohort of hospitalized children Respiratory virus infections in hospitalized children and adults in Lao PDR Respiratory viral coinfections identified by a 10-plex real-time reverse-transcription polymerase chain reaction assay in patients hospitalized with severe acute respiratory illness-South Africa Etiology and Epidemiology of Viral Pneumonia Among Hospitalized Children in Rural Mozambique Adenoviruses in the immunocompromised host Detection of new respiratory viruses in hospitalized infants with bronchiolitis: a three-year prospective study Lower respiratory tract infection in hospitalized children Viral etiology of lower respiratory tract infections in hospitalized children in Mexico RNA viruses in young nepalese children hospitalized with severe pneumonia Human bocavirus-the first 5 years Viral etiologies of acute respiratory infections among hospitalized vietnamese children in Ho Chi Minh city Viral Etiology of Acute Respiratory Tract Infections in Children Presenting to Hospital Rates of respiratory virusassociated hospitalization in children aged <5 years in rural northern India Performance of diagnostic tests to detect respiratory viruses in older adults Detecting respiratory viruses in asymptomatic children Viral and bacterial causes of severe acute respiratory illness among children aged less than 5 years in a high malaria prevalence area of western Kenya Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in children Viral etiology of SARI in Cameroon The Authors. Respiratory viruses were associated with a high burden of hospitalizations among children in Cameroon. keywords: children; infections; influenza; sari; study; viruses; years cache: cord-293354-55nawxos.txt plain text: cord-293354-55nawxos.txt item: #241 of 427 id: cord-293897-p30wz7b7 author: Waghmare, Alpana title: Respiratory viruses date: 2020-04-24 words: 5888 flesch: 23 summary: Several risk scores have been proposed for adult HCT recipients with respiratory virus infections to predict the risk of progression to lower respiratory tract infection and mortality. Progression, shedding patterns, and clinical disease associated with respiratory virus infections after allogeneic hematopoietic cell transplantation A multicenter consortium to define the epidemiology and outcomes of inpatient respiratory viral infections in pediatric hematopoietic stem cell transplant recipients keywords: disease; hct; infection; influenza; patients; recipients; rsv; tract; transplant; virus; viruses cache: cord-293897-p30wz7b7.txt plain text: cord-293897-p30wz7b7.txt item: #242 of 427 id: cord-294062-3esrg1jw author: Tam, Clarence C. title: Association between semi-quantitative microbial load and respiratory symptoms among Thai military recruits: a prospective cohort study date: 2018-09-14 words: 4514 flesch: 33 summary: Viruses were detected in 13.8% (43/312) and bacteria in 93.3% (291/312) of non-acute samples. Hi-nonB, rhinovirus, and coronavirus 229 were detected significantly less frequently in non-acute samples collected at the start of the training period than acute samples (p-values < 0.05) ( Table 1) . keywords: acute; infection; load; non; samples; specimens; tract; value cache: cord-294062-3esrg1jw.txt plain text: cord-294062-3esrg1jw.txt item: #243 of 427 id: cord-294155-94skyx5f author: Terrosi, Chiara title: Human bocavirus detection in an atopic child affected by pneumonia associated with wheezing date: 2007-08-07 words: 1361 flesch: 45 summary: A panel of bacteria and respiratory viruses were searched in the nasopharyngeal swab, only human bocavirus was detected by PCR. CONCLUSIONS: Detection of HboV, as the only microbial agent, in samples from children with wheezing and acute respiratory diseases supports the assumption that this emerging virus could have an aetiologic role in the pathogenesis of respiratory diseases. keywords: hbov; human cache: cord-294155-94skyx5f.txt plain text: cord-294155-94skyx5f.txt item: #244 of 427 id: cord-294544-iutcduix author: Kesson, Alison M. title: Respiratory virus infections date: 2007-09-06 words: 6059 flesch: 35 summary: Respiratory virus infections represent a major public health problem because of their worldwide occurrence, ease of spread in the community and considerable morbidity and mortality. Mortality from respiratory virus infections in healthy individuals in developed countries is rare; however, in less developed countries childhood mortality can be quite high with an estimated 5 million children globally under 5 years dying annually from respiratory virus infections. keywords: cause; cell; children; culture; detection; infection; influenza; rsv; tract; virus; viruses cache: cord-294544-iutcduix.txt plain text: cord-294544-iutcduix.txt item: #245 of 427 id: cord-294568-12eyo13f author: Fernandes-Matano, Larissa title: Prevalence of non-influenza respiratory viruses in acute respiratory infection cases in Mexico date: 2017-05-03 words: 4936 flesch: 41 summary: Real-Time RT-PCR Assay for Non-Influenza Respiratory Viruses Anuario de Morbilidad Lineamientos para la Vigilancia de Influenza por Laboratorio Viral coinfection in acute respiratory infection in Mexican children treated by the emergency service: A cross-sectional study The frequency and seasonality of influenza and other respiratory viruses in Tennessee: two influenza seasons of surveillance data Surveillance for severe acute respiratory infections in Southern Arizona Prevalence of respiratory virus in symptomatic children in private physician office settings in five communities of the state of Veracruz, Mexico Influenza and other respiratory virus infections in outpatients with medically attended acute respiratory infection during Human rhinovirus and disease severity in children Rhinovirus infection in children hospitalized with acute bronchiolitis and its impact on subsequent wheezing or asthma: a comparison of etiologies The role of rhinovirus in asthma exacerbations The ABCs of rhinoviruses, wheezing, and asthma Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production Pathogenesis of rhinovirus infection Frequency of viruses associated with acute respiratory infections in children younger than five years of age at a locality of Mexico City Comparative viral frequency in Mexican children under 5 years of age with and without upper respiratory symptoms According to data from the Secretary of Health, approximately 80% of the samples from patients with ARIs that are received for confirmation of influenza virus infection outside of flu season are negative for the different strains of this virus and remain without a defined aetiology. keywords: age; aris; cases; children; human; infections; influenza; prevalence; samples; study; viruses cache: cord-294568-12eyo13f.txt plain text: cord-294568-12eyo13f.txt item: #246 of 427 id: cord-294933-oc2glu4a author: Cinesi Gómez, César title: Clinical consensus recommendations regarding non-invasive respiratory support in the adult patient with acute respiratory failure secondary to SARS-CoV-2 infection date: 2020-06-19 words: 5647 flesch: 39 summary: An official clinical practice guideline of the Severe acute respiratory syndrome (SARS) ---lessons for future pandemics MERS transmission and risk factors: a systematic review Clinical practice guidelines by the Infectious Diseases Society of America: 2018 update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak management of seasonal influenza Highlights in acute respiratory failure High-flow nasal cannula oxygen therapy is superior to conventional oxygen therapy but not to noninvasive mechanical ventilation on intubation rate: a systematic review and meta-analysis Current evidence for the effectiveness of heated and humidified high flow nasal cannula supportive therapy in adult patients with respiratory failure British Thoracic Society/Intensive Care Society Guideline for the ventilatory management of acute hypercapnic respiratory failure in adults Extracorporeal membrane oxygenation for critically ill adults Noninvasive ventilation in acute hypercapnic respiratory failure Effectiveness of noninvasive positive pressure ventilation in the treatment of acute respiratory failure in severe acute respiratory syndrome Noninvasive mechanical ventilation in severe pneumonia due to H1N1 virus Pandemic 2009 influenza A in Argentina: a study of 337 patients on mechanical ventilation Early non-invasive ventilation treatment for severe influenza pneumonia Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected Severe SARS-CoV-2 infections: practical considerations and management strategy for intensivists. A fundamental element in the management of ARF in COVID-19 patients in monitoring ---preferably of a non-invasive nature. keywords: covid-19; disease; failure; flow; healthcare; infection; management; nasal; nimv; oxygen; patients; sars; therapy; use; ventilation cache: cord-294933-oc2glu4a.txt plain text: cord-294933-oc2glu4a.txt item: #247 of 427 id: cord-295074-fsbp4fky author: Broor, Shobha title: Rates of respiratory virus-associated hospitalization in children aged <5 years in rural northern India date: 2013-11-21 words: 3904 flesch: 26 summary: We found that respiratory virus infections were associated with 40% of acute medical illness hospitalizations among children aged <5 years, and one in five children hospitalized for acute medical illness had RSV infection. Though respiratory viruses are thought to cause substantial morbidity globally in children aged <5 years, the incidence of severe respiratory virus infections in children is unknown in India where 20% of the world's children live. keywords: children; hospitalizations; influenza; rsv; study; virus; viruses; years cache: cord-295074-fsbp4fky.txt plain text: cord-295074-fsbp4fky.txt item: #248 of 427 id: cord-295189-bz3gi15h author: Jennings, Lance C. title: Respiratory viruses in airline travellers with influenza symptoms: Results of an airport screening study date: 2015-03-14 words: 3265 flesch: 42 summary: Even though fever and cough were most frequently identified in association with influenza infections, surveillance data were often obtained over long periods with varying levels of influenza virus activity, resulting in a low PPV for these symptoms for influenza virus infection [26] . While, these and previous reports documenting seasonal influenza among air travelers [2, [9] [10] [11] have focused primarily on the in-flight transmission of influenza, clearly air travellers are responsible for the introduction of influenza viruses into countries on an ongoing basis keywords: infection; influenza; study; symptoms; travellers; virus; viruses cache: cord-295189-bz3gi15h.txt plain text: cord-295189-bz3gi15h.txt item: #249 of 427 id: cord-296605-p67twx7a author: LAU, Arthur Chun-Wing title: Management of Critically Ill Patients with Severe Acute Respiratory Syndrome (SARS) date: 2004-03-10 words: 4848 flesch: 34 summary: In this article, we aim to focus on the management of the subgroup of SARS patients who are critically ill. In one-third to half of SARS patients, fever may recur while on immunomodulatory treatment due to superimposed infections, too rapid tailing of corticosteroids or persistently severe and uninhibited cytokine storm. keywords: acute; clinical; corticosteroids; failure; icu; infection; patients; pressure; sars; syndrome; treatment; ventilation cache: cord-296605-p67twx7a.txt plain text: cord-296605-p67twx7a.txt item: #250 of 427 id: cord-296777-6xz2aslj author: Oosterhof, L title: Fatal lower respiratory tract disease with human corona virus NL63 in an adult haematopoietic cell transplant recipient date: 2009-10-12 words: 1198 flesch: 48 summary: In the light of the clinical features, continuous lymphocytopenia and the detection of HCoV NL 63 in the BAL fluid taken at the day of admission, the respiratory disease in this patient is considered significant for HCoV NL63 lower respiratory tract infection. The clinical course of HCoV NL63 infection is more severe in immunocompromised patients. keywords: day; hcov; nl63; patient cache: cord-296777-6xz2aslj.txt plain text: cord-296777-6xz2aslj.txt item: #251 of 427 id: cord-296836-aizquh16 author: Brenner, Hermann title: Vitamin D Insufficiency and Deficiency and Mortality from Respiratory Diseases in a Cohort of Older Adults: Potential for Limiting the Death Toll during and beyond the COVID-19 Pandemic? date: 2020-08-18 words: 4449 flesch: 34 summary: It has been suggested that vitamin D(3) supplementation might help to reduce respiratory disease mortality. Overall, 41% (95% confidence interval: 20–58%) of respiratory disease mortality was statistically attributable to vitamin D insufficiency or deficiency. keywords: 25(oh)d; covid-19; deficiency; disease; insufficiency; levels; mortality; vitamin cache: cord-296836-aizquh16.txt plain text: cord-296836-aizquh16.txt item: #252 of 427 id: cord-299379-ch7a39d6 author: De Conto, Flora title: Epidemiology of human respiratory viruses in children with acute respiratory tract infection in a 3-year hospital-based survey in Northern Italy() date: 2019-01-17 words: 4013 flesch: 40 summary: Application to typing of enteroviruses (Coxsackie and ECHO) Etiology and clinical characteristics of single and multiple respiratory virus infections diagnosed in croatian children in two respiratory seasons Epidemiology of human respiratory viruses in children with acute respiratory tract infections in Jinan, China Multiple versus single virus respiratory infections: viral load and clinical disease severity in hospitalized children Four year incidence of respiratory syncytial virus infection in infants and young children referred to emergency departments for lower respiratory tract diseases in Italy: the Osservatorio VRS study Respiratory virus detection and clinical diagnosis in children attending day care The burden of human metapneumovirus and respiratory syncytial virus infections in hospitalized norwegian children Viruses as sole causative agents of severe acute respiratory tract infections in children Occurrence of respiratory virus: time, place and person Seasonality of influenza in the tropics: a distinct pattern in northeastern Brazil Respiratory syncytial virus bronchiolitis, weather conditions and air pollution in an Italian urban area: an observational study Acute respiratory infections in hospitalized children in Vientiane, Lao PDR -the importance of respiratory syncytial virus Etiology, seasonality, and clinical characteristics of respiratory viruses in children with respiratory tract infections in Eastern India (Bhubaneswar, Odisha) Mixed respiratory virus infections Ten years (2004-2014) of influenza surveillance in Northern Italy Multipathogen infections in hospitalized children with acute respiratory infections Causative agents of severe community acquired viral pneumonia among children in Eastern Thailand Concurrent serious bacterial infections in 912 infants and children hospitalized for treatment of respiratory syncytial virus lower respiratory tract infection Human bocavirus: passenger or pathogen in acute respiratory tract infections? Etiology and clinical outcomes of acute respiratory virus infection in hospitalized adults Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study Retrospective review of serious bacterial infections in infants who are 0 to 36 months of age and have influenza A infection Respiratory viruses and influenza-like illness: epidemiology and outcomes in children aged 6 months to 10 years in a multi-country population sample Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology Fifteen years of epidemiologic, virologic and syndromic influenza surveillance: a focus on type B virus and the effects of vaccine mismatch in Liguria region Respiratory virus surveillance in hospitalised pneumonia patients on the Thailand-Myanmar border Contribution of common and recently described respiratory viruses to annual hospitalizations in children in South Africa Severity of pandemic H1N1 2009 influenza virus infection may not be directly correlated with initial viral load in upper respiratory tract Epidemiological and molecular surveillance of influenza and respiratory syncytial viruses in children with acute respiratory infections Epidemiological and clinical features of respiratory viral infections in hospitalized children during the circulation of influenza virus A (H1N1) The main diagnostic methods for respiratory virus infections are: virus isolation in cell culture, viral antigen/nucleic acid detection, and virus-specific serology. keywords: children; hrsv; infections; respiratory; samples; virus; viruses; years cache: cord-299379-ch7a39d6.txt plain text: cord-299379-ch7a39d6.txt item: #253 of 427 id: cord-299835-92karhpl author: Ho, Khek Y. title: Mild Illness Associated with Severe Acute Respiratory Syndrome Coronavirus Infection: Lessons from a Prospective Seroepidemiologic Study of Health-Care Workers in a Teaching Hospital in Singapore date: 2004-02-17 words: 3528 flesch: 48 summary: The present study is the first to document SARS infection in HCWs with normal chest radiographs. The second important finding we observed is that individuals who did not have direct contact with patients with SARS also both developed clinical SARS and experienced seroconversion with milder illness. keywords: contact; hcws; hospital; patients; samples; sars; syndrome cache: cord-299835-92karhpl.txt plain text: cord-299835-92karhpl.txt item: #254 of 427 id: cord-299952-xvtt8fz8 author: Gao, LuLu title: A randomized controlled trial of low-dose recombinant human interferons α-2b nasal spray to prevent acute viral respiratory infections in military recruits date: 2010-06-17 words: 4448 flesch: 45 summary: The efficacy of intranasal interferon alpha-2a in respiratory syncytial virus infection in volunteers Prevention of experimental coronavirus colds with intranasal alpha-2b interferon Treatment of respiratory syncytial virus infection with recombinant interferon alfa-2a Could preventive intranasal interferon lower the morbidity in children prone to respiratory illness? Though most of viral respiratory infections usually represent mild, selflimited clinical manifestations, they are leading causes of morbidity in certain groups or populations (e.g., children, military population) and remain a heavy burden of disease keywords: control; flu; group; infections; military; nasal; spray; virus cache: cord-299952-xvtt8fz8.txt plain text: cord-299952-xvtt8fz8.txt item: #255 of 427 id: cord-300019-8vxqr3mc author: Shi, Ting title: The Etiological Role of Common Respiratory Viruses in Acute Respiratory Infections in Older Adults: A Systematic Review and Meta-analysis date: 2019-03-08 words: 3968 flesch: 39 summary: Communityacquired pneumonia requiring hospitalization among U.S. children Better tests, better care: improved diagnostics for infectious diseases Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study Identification of respiratory viruses in adults: nasopharyngeal versus oropharyngeal sampling Lower respiratory tract virus findings in mechanically ventilated patients with severe community-acquired pneumonia Time lines of infection and disease in human influenza: a review of volunteer challenge studies Flu Watch Group. We aimed to identify all case-control studies investigating the potential role of respiratory viruses in the etiology of ARI in older adults aged ≥65 years. keywords: adults; ari; control; disease; group; pneumonia; studies; viruses cache: cord-300019-8vxqr3mc.txt plain text: cord-300019-8vxqr3mc.txt item: #256 of 427 id: cord-300116-r93w4jm3 author: Yi, Hana title: Profiling bacterial community in upper respiratory tracts date: 2014-11-13 words: 5068 flesch: 35 summary: First, the age-related incidence of M. nonliquefaciens infection determined here is concordant with that of M. catarrhalis. Previously, M. catarrhalis was reported to be mostly associated with upper respiratory tract infections in children [50] , and its carriage rate was shown to be high in children (up to 75%) and extremely low in healthy adults (1%-3%) keywords: catarrhalis; community; microbiota; moraxella; nonliquefaciens; patients; samples; tract; type cache: cord-300116-r93w4jm3.txt plain text: cord-300116-r93w4jm3.txt item: #257 of 427 id: cord-300510-fhpkdqr0 author: Mojoli, Francesco title: Our recommendations for acute management of COVID-19 date: 2020-05-08 words: 1085 flesch: 32 summary: Rapid response to COVID-19 outbreak in Northern Italy: how to convert a classic infectious disease ward into a COVID-19 response centre Effect of noninvasive ventilation delivered by helmet vs face mask on the rate of endotracheal intubation in patients with acute respiratory distress syndrome: a randomized clinical trial Critical care management of adults with community-acquired severe respiratory viral infection Clinical management of severe acute respiratory infection when Novel coronavirus (2019-nCoV) infection is suspected: Interim Guidance 28 Esophageal and transpulmonary pressure in the clinical setting: meaning, usefulness and perspectives Lung ultrasound for critically ill patients Assessment of lung aeration and recruitment by CT scan and ultrasound in acute respiratory distress syndrome patients Lung ultrasound for early diagnosis of ventilator-associated pneumonia Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China Thrombotic events in SARS-Cov 2 patients: an urgent call for ultrasound screening Setup of a dedicated coronavirus intensive care unit: logistical aspects Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations 7. Perform early intubation if poor response to continuous positive airway pressure in terms of oxygenation: do not trust patients' relatively good respiratory mechanics and feeling of improved dyspnoea, since these patients may have relatively normal lung compliance and the only clinical sign of fatigue may be high respiratory rate. keywords: care; coronavirus; lung; patients; pressure cache: cord-300510-fhpkdqr0.txt plain text: cord-300510-fhpkdqr0.txt item: #258 of 427 id: cord-300711-yibdumij author: Shatizadeh, Somayeh title: Epidemiological and clinical evaluation of children with respiratory virus infections date: 2014-09-22 words: 2025 flesch: 38 summary: Although routine surveillance of respiratory viruses might not seem to be MJIRI, Vol. 28 Peres Cd Cde A. Factors associated to hospitalization of children under five years of age Epidemiology and seasonality of respiratory tract virus infections in the tropics Human bocavirus infection in young children in the united states: molecular epidemiological profile and clinical characteristics of a newly emerging respiratory virus Epidemiology and clinical characteristics of respiratory syncytial virus infections in Jordan Molecular Evolution and Circulation Patterns of Human Respiratory Syncytial Virus Subgroup A: Positively Selected Sites in the Attachment G Glycoprotein Development of three multiplex RT-PCR assays for the detection of 12 respiratory RNAviruses Rapid and Sensitive Method Using Multiplex Real-Time PCR for Diagnosis of Infections by Influenza A and Influenza B Viruses, Respiratory Syncytial Virus, and Parainfluenza Viruses 1, 2, 3, and 4 GeneScan Reverse Transcription-PCR Assay for Detection of Six Common Respiratory Viruses in Young Children Hospitalized with Acute Respiratory Illness Detection and Identification of Human Parainfluenza Viruses 1, 2, 3, and 4 in Clinical Samples of Pediatric Patients by Multiplex Reverse Transcription-PCR Comparison of Multiplex Nested RT-PCR with Virus Isolation for Detection of Influenza Viruses A and B Molecular Identification of Adenoviruses in Clinical Samples by Analyzing a Partial Hexon Genomic Region Simultaneous Detection of Fourteen Respiratory Viruses in Clinical Specimens by Two Multiplex Reverse Transcription Nested-PCR Assays Multiple viral respiratory pathogens in children with bronchiolitis Clinicalepidemiological evaluation of respiratory syncytial virus infection in children attended in a public hospital in midwestern Brazil Role of Respiratory Viruses in Acute Upper and Lower Respiratory Tract Illness in the First Year of Life: A Birth Cohort Study Molecular detection of respiratory viruses in children with acute respiratory disease in Iran Seasonal Trends of Human Parainfluenza Viral Infections: United States Prevalence of respiratory viruses, including newly identified viruses, in hospitalized children in Austria Epidemiological and clinical features of hMPV, RSV and RVs infections in young children Respiratory viral infections among pediatric inpatients and outpatients in Taiwan from 1997 to 1999 Respiratory Viral Infections among Pediatric Inpatients and Outpatients in Taiwan from 1997 to 1999 The pathogenesis of respiratory syncytial virus disease in childhood We would like to thank the entire staff of the National Influenza centre, School of Public Health Tehran University of Medical Sciences. RSV causes the great majority of respiratory virus infections in children. keywords: age; children; infections; study; viruses cache: cord-300711-yibdumij.txt plain text: cord-300711-yibdumij.txt item: #259 of 427 id: cord-301011-xbuqd0j5 author: Felten-Barentsz, Karin M title: Recommendations for Hospital-Based Physical Therapists Managing Patients With COVID-19 date: 2020-06-18 words: 3953 flesch: 32 summary: Therefore, we recommend to not detach the ventilation system for the purpose of respiratory function testing, respiratory muscle training, or breathing exercises. The team may decide that benefits of respiratory muscle training outweigh the safety risks. keywords: covid-19; hospital; mobilization; muscle; patients; recommendations; support; therapists; training cache: cord-301011-xbuqd0j5.txt plain text: cord-301011-xbuqd0j5.txt item: #260 of 427 id: cord-301254-093yih5n author: Brittain-Long, Robin title: Prospective evaluation of a novel multiplex real-time PCR assay for detection of fifteen respiratory pathogens—Duration of symptoms significantly affects detection rate date: 2010-01-18 words: 2860 flesch: 40 summary: Development of three multiplex RT-PCR assays for the detection of 12 respiratory RNA viruses Development and implementation of a molecular diagnostic platform for daily rapid detection of 15 respiratory viruses Practical experience of high throughput real time PCR in the routine diagnostic virology setting Respiratory viruses and severe lower respiratory tract complications in hospitalized patients Enhanced identification of viral and atypical bacterial pathogens in lower respiratory tract samples with nucleic acid amplification tests Impact of rapid detection of viral and atypical bacterial pathogens by real-time polymerase chain reaction for patients with lower respiratory tract infection Surveillance of respiratory virus infections in adult hospital admissions using rapid methods High prevalence of respiratory viral infections in patients hospitalized in an intensive care unit for acute respiratory infections as detected by nucleic acid-based assays Detection of respiratory viruses by molecular methods A recently identified rhinovirus genotype is associated with severe respiratory-tract infection in children in Germany Rhinovirus associated with severe lower respiratory tract infections in children Rapid multiplex nested PCR for detection of respiratory viruses Influenza diagnosis: from dark isolation into the molecular light West of Scotland Respiratory Virus Study Group Multiplex real-time PCR for detection of respiratory tract infections Duration of influenza A virus shedding in hospitalized patients and implications for infection control Aetiological role of viral and bacterial infections in acute adult lower respiratory tract infection (LRTI) in primary care Development of a respiratory virus panel test for detection of twenty human respiratory viruses by use of multiplex PCR and a fluid microbead-based assay Viral etiology of common cold in children Comparison of multiplex PCR assays and conventional techniques for the diagnostic of respiratory virus infections in children admitted to hospital with an acute respiratory illness Human picornavirus and coronavirus RNA in nasopharynx of children without concurrent respiratory symptoms Predominance of rhinovirus in the nose of symptomatic and asymptomatic infants Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in children Rapid and sensitive method using multiplex real-time PCR for diagnosis of infections by influenza A and influenza B viruses, respiratory syncytial virus, and parainfluenza viruses 1, 2, 3, and 4 Respiratory viral infections in transplant recipients Respiratory virus infection among hematopoietic cell transplant recipients: evidence for asymptomatic parainfluenza virus infection Correlation of viral load as determined by real-time RT-PCR and clinical characteristics of respiratory syncytial virus lower respiratory tract infections in early infancy Human respiratory syncytial virus (hRSV) RNA quantification in nasopharyngeal secretions identifies the hRSV etiologic role in acute respiratory tract infections of hospitalized infants Respiratory picornavirus infections in Korean children with lower respiratory tract infections Detection and typing by molecular techniques of respiratory viruses in children hospitalized for acute respiratory infection in Rome, Italy Multiple simultaneous viral infections in infants with acute respiratory tract infections in Spain Real-time polymerase chain reaction (PCR) techniques are gaining increasing acceptance for diagnosis of viral respiratory tract infections (RTI). keywords: detection; infections; patients; pcr; respiratory; symptoms cache: cord-301254-093yih5n.txt plain text: cord-301254-093yih5n.txt item: #261 of 427 id: cord-301988-cevv81h3 author: Hassoun, Ali title: Seasonal variation of respiratory pathogen colonization in asymptomatic health care professionals: A single-center, cross-sectional, 2-season observational study date: 2015-08-01 words: 3072 flesch: 35 summary: key: cord-301988-cevv81h3 authors: Hassoun, Ali; Huff, Matthew D.; Weisman, David; Chahal, Khushdeep; Asis, Esmeralda; Stalons, Don; Grigorenko, Elena; Green, Jessica; Malone, Leslie L.; Clemmons, Scott; Lu, Stanley title: Seasonal variation of respiratory pathogen colonization in asymptomatic health care professionals: A single-center, cross-sectional, 2-season observational study date: 2015-08-01 journal: Am J Infect Control DOI: 10.1016/j.ajic.2015.04.195 sha: doc_id: 301988 cord_uid: cevv81h3 BACKGROUND: The purpose of this study was to determine the seasonal variance of potentially pathogenic bacterial and viral organisms in nasopharyngeal specimens obtained from asymptomatic health care professionals (HCPs) during the 2014 winter and summer months. Microbial interactions during upper respiratory tract infections Bacterial interference in upper respiratory tract infections: a systematic review Respiratory microbiota: addressing clinical questions, informing clinical practice Seasonal infectious disease epidemiology Hospital epidemiology and infection control in acute-care settings Colonization of severe acute respiratory syndrome-associated coronavirus among health-care workers screened by nasopharyngeal swab Fighting the SARS epidemic in Taiwan: a nursing perspective Branamella catarrhalis in children and adults. keywords: asymptomatic; colonization; hcps; infection; study; summer; winter cache: cord-301988-cevv81h3.txt plain text: cord-301988-cevv81h3.txt item: #262 of 427 id: cord-302111-kg0dmgq0 author: Darden, Dijoia B. title: The Clinical Presentation and Immunology of Viral Pneumonia and Implications for Management of Coronavirus Disease 2019 date: 2020-04-29 words: 4498 flesch: 21 summary: Severe viral pneumonia can manifest as sepsis and respiratory distress requiring intensive care (11) . The most severely ill group of 12 patients demonstrated impaired expression of numerous genes participating in adaptive immune responses (e.g., diminished antigen presentation, B-cell development, T-helper cell differentiation, and apoptosis), suggesting impaired adaptive immunity in severe viral pneumonia (55) . keywords: community; coronavirus; covid-19; disease; infection; influenza; patients; pneumonia; presentation; review; sars; vaccine cache: cord-302111-kg0dmgq0.txt plain text: cord-302111-kg0dmgq0.txt item: #263 of 427 id: cord-302833-6kntd89t author: Radonovich, Lewis J. title: The Respiratory Protection Effectiveness Clinical Trial (ResPECT): a cluster-randomized comparison of respirator and medical mask effectiveness against respiratory infections in healthcare personnel date: 2016-06-02 words: 5093 flesch: 32 summary: key: cord-302833-6kntd89t authors: Radonovich, Lewis J.; Bessesen, Mary T.; Cummings, Derek A.; Eagan, Aaron; Gaydos, Charlotte; Gibert, Cynthia; Gorse, Geoffrey J.; Nyquist, Ann-Christine; Reich, Nicholas G.; Rodrigues-Barradas, Maria; Savor-Price, Connie; Shaffer, Ronald E.; Simberkoff, Michael S.; Perl, Trish M. title: The Respiratory Protection Effectiveness Clinical Trial (ResPECT): a cluster-randomized comparison of respirator and medical mask effectiveness against respiratory infections in healthcare personnel date: 2016-06-02 journal: BMC Infect Dis DOI: 10.1186/s12879-016-1494-2 sha: doc_id: 302833 cord_uid: 6kntd89t BACKGROUND: Although N95 filtering facepiece respirators and medical masks are commonly used for protection against respiratory infections in healthcare settings, more clinical evidence is needed to understand the optimal settings and exposure circumstances for healthcare personnel to use these devices. keywords: healthcare; illness; infections; influenza; laboratory; masks; n95; participants; protection; respect; respirators; study; transmission cache: cord-302833-6kntd89t.txt plain text: cord-302833-6kntd89t.txt item: #264 of 427 id: cord-303040-ha8gufh8 author: Park, Won-Ju title: Respiratory Syncytial Virus Outbreak in the Basic Military Training Camp of the Republic of Korea Air Force date: 2015-01-14 words: 3620 flesch: 45 summary: Medical microvirology Genetic diversity among respiratory syncytial viruses that have caused repeated infections in children from rural India The burden of respiratory syncytial virus infection in young children Seroprevalence of respiratory syncytial virus IgG among healthy young adults in basic training for the Republic of Korea Air Force Mortality associated with influenza and respiratory syncytial virus in the United States Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis Respiratory syncytial virus is an important cause of community-acquired lower respiratory infection among hospitalized adults Symptomatic respiratory syncytial virus infection in previously healthy young adults living in a crowded military environment Respiratory syncytial virus: an important cause of acute respiratory illness among young adults undergoing military training. Influenza Other Respir Viruses Detection of respiratory syncytial virus in adults with chronic obstructive pulmonary disease Humoral immunity to respiratory syncytial virus in young and elderly adults RSV infection in elderly adults Respiratory syncytial virus infection in adult populations Respiratory syncytial virus and parainfluenza virus Clinical and epidemiological comparison of human metapneumovirus and respiratory syncytial virus in seoul Yogev R. Residential crowding and severe respiratory syncytial virus disease among infants and young children: a systematic literature review Respiratory diseases among U.S. military personnel: countering emerging threats Viruses and the lung: keywords: acute; fever; infection; military; patients; rsv; virus cache: cord-303040-ha8gufh8.txt plain text: cord-303040-ha8gufh8.txt item: #265 of 427 id: cord-303299-p15irs4e author: Dzien, Alexander title: Will the COVID-19 pandemic slow down in the Northern hemisphere by the onset of summer? An epidemiological hypothesis date: 2020-06-23 words: 1264 flesch: 44 summary: The colored lines plot the seasons in which previous pandemic respiratory infections have been recorded (02/03 SARS-CoV, purple line; 04/05 H5N1, green line; 09/10 pandemic flu, blue line) Novel coronavirus: where we are and what we know Successful containment of COVID-19: the WHO-Report on the COVID-19 outbreak in China Spatiotemporal circulation of influenza viruses in 5 African countries during 2008-2009: a collaborative study of the Institut Pasteur International Network Consecutive infections with influenza A and B virus in children during the 2014-2015 seasonal influenza epidemic Seasonality of respiratory viral infections Pandemic influenza control in Europe and the constraints resulting from incoherent public health laws SARS and other coronaviruses as causes of pneumonia Epidemiologic characterization of the 1918 influenza pandemic summer wave in Copenhagen: implications for pandemic control strategies Acknowledgements Open access funding provided by University of Innsbruck and Medical University of Innsbruck. keywords: covid-19; diseases; infections; pandemic cache: cord-303299-p15irs4e.txt plain text: cord-303299-p15irs4e.txt item: #266 of 427 id: cord-303322-d69o3z8d author: Chang, Anne B title: Randomized placebo-controlled trial on azithromycin to reduce the morbidity of bronchiolitis in Indigenous Australian infants: rationale and protocol date: 2011-04-14 words: 5437 flesch: 33 summary: Indeed, Indigenous infants are more likely to receive antibiotics for an episode of pneumonia diagnosed during an admission for bronchiolitis than non-Indigenous infants nursed in the same paediatric unit [6] . Bronchiolitis in Indigenous infants is more severe than bronchiolitis in non-Indigenous infants [6] . keywords: azithromycin; bronchiolitis; children; data; hospital; illness; infants; months; placebo; pneumoniae; study; term cache: cord-303322-d69o3z8d.txt plain text: cord-303322-d69o3z8d.txt item: #267 of 427 id: cord-303606-ypkia5x1 author: Lee, So-lun title: Is respiratory viral infection really an important trigger of asthma exacerbations in children? date: 2011-03-30 words: 3529 flesch: 42 summary: Our result was comparable to a clinic-based prospective study [19] and more closely matched to the Canadian case-control study conducted in September 2001 before the epidemics of severe acute respiratory syndrome (SARS) in which 62% of asthma children attending emergency department for exacerbations had respiratory viruses isolated [13] . Respiratory viruses were detected in 61 of 166 episodes (36.7%). keywords: asthma; children; detection; episodes; exacerbations; infections; study; viruses cache: cord-303606-ypkia5x1.txt plain text: cord-303606-ypkia5x1.txt item: #268 of 427 id: cord-303935-qdehf6rb author: Yun, Heather C. title: Changes in Clinical Presentation and Epidemiology of Respiratory Pathogens Associated With Acute Respiratory Illness in Military Trainees After Reintroduction of Adenovirus Vaccine date: 2015-09-01 words: 4254 flesch: 39 summary: Because respiratory illness remains a leading cause of presentation for care among military trainees, understanding of trends in clinical presentation and emerging, non-Ad respiratory pathogens in the post-VI era requires evaluation. Ill or injured trainees present for care at an outpatient medical clinic; those with respiratory illness and fever are then cohorted until well enough to return to training. keywords: illness; military; post; rhinovirus; study; trainees; vaccine cache: cord-303935-qdehf6rb.txt plain text: cord-303935-qdehf6rb.txt item: #269 of 427 id: cord-304876-txaoz7oh author: Jordan, Paul C title: Nucleosides for the treatment of respiratory RNA virus infections date: 2018-03-21 words: 11008 flesch: 38 summary: In this review, we summarized the exciting advances in discovery and development of novel nucleoside analogs as potential new treatments for respiratory RNA virus infections. Despite these challenges, the prospect of developing nucleoside analogs directed against respiratory RNA virus infections represents an exciting new avenue in antiviral research. keywords: activity; analogs; cov; domain; gs-5734; human; infection; influenza; nucleoside; polymerase; protein; replication; ribavirin; rna; rna polymerase; rsv; structure; synthesis; t-705; treatment; virus; viruses; vitro cache: cord-304876-txaoz7oh.txt plain text: cord-304876-txaoz7oh.txt item: #270 of 427 id: cord-306266-8qdrshz3 author: Scully, Crispian title: Respiratory medicine date: 2014-06-25 words: 13246 flesch: 40 summary: Respiratory infections must also be eradicated; sputum should first be sent for culture and sensitivity, but antimicrobials such as amoxicillin should be started without await ing results. Immunocompromised persons (e.g. those with human immunode ficiency virus/acquired immune deficiency syndrome [HIV/AIDS] and transplant recipients) and people with bronchiectasis or cystic fibrosis are also susceptible to respiratory infections by a range of opportun istic microbes. keywords: asthma; blood; cases; cause; chest; copd; cough; diagnosis; disease; drugs; dyspnoea; infection; influenza; lung; obstruction; oxygen; patients; people; pneumonia; pulmonary; result; risk; sputum; symptoms; syndrome; table; therapy; treatment; tuberculosis cache: cord-306266-8qdrshz3.txt plain text: cord-306266-8qdrshz3.txt item: #271 of 427 id: cord-306278-c4q4la5c author: Esposito, Susanna title: Epidemiology and Clinical Characteristics of Respiratory Infections Due to Adenovirus in Children Living in Milan, Italy, during 2013 and 2014 date: 2016-04-05 words: 4662 flesch: 43 summary: Overall, little data on HAdV circulation have been collected in Europe and no recent data regarding the epidemiology, molecular characterization, and clinical features of respiratory HAdV infections in children have been collected in Italy. [22, 23] , where this virus was the predominant type for respiratory HAdV infection from 1981 to 2002. keywords: adenovirus; cases; children; hadv; infection; load; pcr; species; study; time cache: cord-306278-c4q4la5c.txt plain text: cord-306278-c4q4la5c.txt item: #272 of 427 id: cord-306315-vt2e0crh author: Elabbadi, Alexandre title: Respiratory virus-associated infections in HIV-infected adults admitted to the intensive care unit for acute respiratory failure: a 6-year bicenter retrospective study (HIV-VIR study) date: 2020-09-14 words: 4743 flesch: 30 summary: Medicine (Baltimore) Respiratory viruses in HIV-infected patients with suspected respiratory opportunistic infection Outcome of critically ill human immunodeficiency virus-infected patients in the era of highly active antiretroviral therapy Survival of HIV-infected patients in the intensive care unit in the era of highly active antiretroviral therapy Etiology of pulmonary infections in human immunodeficiency virus-infected inpatients using sputum multiplex real-time polymerase chain reaction Impact of HIV infection and smoking on lung immunity and related disorders Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaques A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD Cigarette smoke decreases innate responses of epithelial cells to rhinovirus infection Cigarette smoke attenuates the RIG-I-initiated innate antiviral response to influenza infection in two murine models Cigarette smoke suppresses TLR-7 stimulation in response to virus infection in plasmacytoid dendritic cells Recording of influenza-like illness in UK primary care 1995-2013: cohort study Incidence and risk factors for influenza-like-illness in the UK: online surveillance using Flusurvey Respiratory viruses in young South African children with acute lower respiratory infections and interactions with HIV Etiology and epidemiology of viral pneumonia among hospitalized children in rural Mozambique: a malaria endemic area with high prevalence of human immunodeficiency virus Pandemic (H1N1) 2009 influenza virus seroconversion rates in HIV-infected individuals Incidence of respiratory viruses in patients with community-acquired pneumonia admitted to the intensive care unit: results from the Severe Influenza Pneumonia Surveillance (SIPS) project Clinical epidemiology of bocavirus, rhinovirus, two polyomaviruses and four coronaviruses in HIV-infected and HIV-uninfected South African children Respiratory virus detection in immunocompromised patients with FilmArray respiratory panel compared to conventional methods Virological diagnosis in community-acquired pneumonia in immunocompromised patients Prolonged shedding of rhinovirus and re-infection in adults with respiratory tract illness Chronic rhinoviral infection in lung transplant recipients Persistent human rhinovirus type C infection of the lower respiratory tract in a pediatric cord blood transplant recipient Persistent rhinovirus infection in pediatric hematopoietic stem cell transplant recipients with impaired cellular immunity Viral infection in community-acquired pneumonia: a systematic review and meta-analysis Coinfection with Streptococcus pneumoniae negatively modulates the size and composition of the ongoing influenza-specific CD8 + T cell response Role of tissue protection in lethal respiratory viral-bacterial coinfection Influenza virus primes mice for pneumonia from Staphylococcus aureus Pneumocystis infection enhances antibodymediated resistance to a subsequent influenza infection Diagnosis and management of respiratory viruses in critically ill adult patients: an international survey of knowledge and practice among intensivists Diagnostic value of microscopic examination of Gram-stained sputum and sputum cultures in patients with bacteremic pneumococcal pneumonia Comparison of sputum and nasopharyngeal swabs for detection of respiratory viruses Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations None. GV had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis, including and especially any adverse effects. Additional information on Material and methods, Table S1 (Panels of mPCR kits used in the two participating ICUs over the 6-year study period), Table S2 (Microbiological investigations performed in 123 HIV-infected patients admitted to the ICU for acute respiratory failure, according to the diagnosis of respiratory virus-associated infection), Table S3 (Baseline characteristics, behavior during ICU stay, and outcome of 123 HIV-infected patients admitted to the ICU for acute respiratory failure, according to the diagnosis of respiratory virus-associated infection), Table S4 (Multivariate analysis of the risk factors for death at Day-28 in 123 HIV-infected patients admitted to the ICU for acute respiratory failure), Figure S1 (Distribution of the microbiological documentations in 123 HIVinfected patients admitted to the ICU for acute respiratory failure), Figure S2 Admissions to intensive care unit of HIV-infected patients in the era of highly active antiretroviral therapy: etiology and prognostic factors Etiologies and outcome of acute respiratory failure in HIVinfected patients Temporal trends in critical events complicating HIV infection: 1999-2010 multicentre cohort study in France Survival for patients with HIV admitted to the ICU continues to improve in the current era of combination antiretroviral therapy Pulmonary infections in HIV-infected patients: an update in the 21st century HIV infection and risk for incident pulmonary diseases in the combination antiretroviral therapy era Epidemiology and clinical outcome of virus-positive respiratory samples in ventilated patients: a prospective cohort study Respiratory viruses in invasively ventilated critically ill patients-a prospective multicenter observational study Viral-bacterial coinfection affects the presentation and alters the prognosis of severe community-acquired pneumonia Lower respiratory tract virus findings in mechanically ventilated patients with severe community-acquired pneumonia Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: a single-center retrospective study Virus infection in exacerbations of chronic obstructive pulmonary disease requiring ventilation Procalcitonin algorithm to guide initial antibiotic therapy in acute exacerbations of COPD admitted to the ICU: a randomized multicenter study Epidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease Community surveillance of respiratory viruses among families in the utah better identification of germs-longitudinal viral epidemiology (BIG-LoVE) study Community-acquired pneumonia requiring hospitalization among U.S. adults Clinical significance of upper airway virus detection in critically ill hematology patients Management of respiratory viral infections in hematopoietic cell transplant recipients and patients with hematologic malignancies Prospective etiological investigation of community-acquired pulmonary infections in hospitalized people living with HIV. keywords: acute; cd4; hiv; icu; infection; patients; study; virus cache: cord-306315-vt2e0crh.txt plain text: cord-306315-vt2e0crh.txt item: #273 of 427 id: cord-306411-dutbxfl4 author: Eifan, Saleh A. title: Respiratory Tract Viral Infections and Coinfections Identified by Anyplex™ II RV16 Detection Kit in Pediatric Patients at a Riyadh Tertiary Care Hospital date: 2017-11-21 words: 2643 flesch: 34 summary: Respiratory Pathogens in Children with and without Respiratory Symptoms Epidemiology of respiratory viral infection using multiplex RT-PCR in Virological and clinical characterizations of respiratory infections in hospitalized children Ten year retrospective evaluation of the seasonal distribution of agent viruses in childhood respiratory tract infections Epidemiological and clinical characteristics of respiratory viral infections in children in Viral Etiology of acute respiratory tract infections in hospitalized children and adults in Shandong Province, China Other viruses (e.g. pox, papilloma, parvo, reoviridae) Viral coinfection in childhood respiratory tract infections Etiology, seasonality, and clinical characterization of viral respiratory infections among hospitalized children in Beirut, Lebanon Etiology, seasonality, and clinical characteristics of respiratory viruses in children with respiratory tract infections in Eastern India (Bhubaneswar, Odisha) Respiratory virus infections are a major public health problem, due to the ease of spread and considerable morbidity and mortality. keywords: children; detection; infections; rsv; study; viruses cache: cord-306411-dutbxfl4.txt plain text: cord-306411-dutbxfl4.txt item: #274 of 427 id: cord-306450-sh2mrhoq author: Appak, Özgür title: Viral respiratory infections diagnosed by multiplex polymerase chain reaction in pediatric patients date: 2019-01-03 words: 1748 flesch: 41 summary: High prevalence of HMPV during the H1N1V.2009 pandemic in Poland Molecular diagnosis of respiratory virus infections Epidemiology characteristics of respiratory viruses found in children and adults with respiratory tract infections in southern China Epidemiologic analysis of respiratory viral infections mainly in hospitalized children and adults in Midwest University Medical Center after the implementation of a 14-virus multiplex nucleic acid amplification test Ten year retrospective evaluation of the seasonal distribution of agent viruses in childhood respiratory tract infections Rapid multiplex nested PCR for detection of respiratory viruses Clinical impact of RT-PCR for pediatric acute respiratory infections: a controlled clinical trial Comparison of three multiplex PCR assays for detection of respiratory viruses: Anyplex II RV16, AdvanSure RV, and Real-Q RV The role of multiplex PCR in respiratory tract infections in children Extensive multiplex PCR diagnostics reveal new insights into the epidemiology of viral respiratory infections Analysis of respiratory viral infections detected using multiplex real-time PCR in Hwaseong Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis Human metapneumovirus circulation in the United States Influenza surveillance in five consecutive seasons during post pandemic period: results from National Influenza Center Molecular epidemiology of adenovirus type 7 in the United States Molecular and clinical characteristics of adenoviral infections in Taiwanese children in 2004-2005 Parainfluenza virus infection Seasonal trends of human parainfluenza viral infections: United States Epidemiology of parainfluenza infection in England and Wales, 1998-2013: any evidence of change? key: cord-306450-sh2mrhoq authors: Appak, Özgür; Duman, Murat; Belet, Nurşen; Sayiner, Ayça Arzu title: Viral respiratory infections diagnosed by multiplex polymerase chain reaction in pediatric patients date: 2019-01-03 journal: J Med Virol DOI: 10.1002/jmv.25379 sha: doc_id: 306450 cord_uid: sh2mrhoq Syndromic diagnosis by multiplex nucleic acid amplification tests is the most practical approach to respiratory tract infections since the symptoms are rarely agent‐specific. keywords: children; infections; rsv; study cache: cord-306450-sh2mrhoq.txt plain text: cord-306450-sh2mrhoq.txt item: #275 of 427 id: cord-306480-wgl4zrnb author: Subissi, Lorenzo title: Capturing respiratory syncytial virus season in Belgium using the influenza severe acute respiratory infection surveillance network, season 2018/19 date: 2020-10-01 words: 4148 flesch: 43 summary: AIM: We tested the capacity of the severe acute respiratory infection (SARI) hospital network to contribute to RSV surveillance in Belgium. With only marginal modifications in the case definition and the period of surveillance, the Belgian SARI network would be able to substantially contribute to RSV surveillance and burden evaluation in children and older adults, the two groups of particular interest for WHO. keywords: case; influenza; patients; rsv; sari; surveillance; virus; years cache: cord-306480-wgl4zrnb.txt plain text: cord-306480-wgl4zrnb.txt item: #276 of 427 id: cord-307261-0a3iztns author: Hayden, Randall T. title: Comparison of two broadly multiplexed PCR systems for viral detection in clinical respiratory tract specimens from immunocompromised children date: 2012-01-30 words: 4054 flesch: 43 summary: Instrumentation for the FilmArray process was provided by Idaho Technology, Inc. Development of three multiplex RT-PCR assays for the detection of 12 respiratory RNA viruses Multiplex real-time PCR assay for detection of influenza and human respiratory syncytial viruses Use of a multiplex real-time PCR to study the incidence of human metapneumovirus and human respiratory syncytial virus infections during two winter seasons in a Belgian paediatric hospital Multiplex real-time PCR for detection of respiratory tract infections Evaluation of the Prodesse Hexaplex multiplex PCR assay for direct detection of seven respiratory viruses in clinical specimens Evaluation of the Hexaplex assay for detection of respiratory viruses in children Rapid and sensitive method using multiplex real-time PCR for diagnosis of infections by influenza a and influenza B viruses, respiratory syncytial virus, and parainfluenza viruses 1, 2, 3, and 4 Development of a respiratory virus panel test for detection of twenty human respiratory viruses by use of multiplex PCR and a fluid microbead-based assay MultiCode-PLx system for multiplexed detection of seventeen respiratory viruses Multiplex PCR and emerging technologies for the detection of respiratory pathogens Detection of respiratory viruses by molecular methods Nucleic acid amplification-based diagnosis of respiratory virus infections Cloning of a human parvovirus by molecular screening of respiratory tract samples Human metapneumovirus infections in young and elderly adults Metapneumovirus and acute wheezing in children Human metapneumovirus: a newly emerging respiratory pathogen A newly discovered human pneumovirus isolated from young children with respiratory tract disease Identification of a new human coronavirus Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia A novel multiplex real-time RT-PCR assay with FRET hybridization probes for the detection and quantitation of 13 respiratory viruses Evaluation of commercial ResPlex II v2.0, MultiCode-PLx, and xTAG respiratory viral panels for the diagnosis of respiratory viral infections in adults Immunofluorescence versus xTAG multiplex PCR for the detection of respiratory picornavirus infections in children Viral and atypical bacterial detection in acute respiratory infection in children under five years Comparison of the Eragen multi-code respiratory virus panel with conventional viral testing and real-time multiplex PCR assays for detection of respiratory viruses Clinical evaluation of multiplex real-time PCR panels for rapid detection of respiratory viral infections Rhinovirus and acute respiratory infections in hospitalized children retrospective study Multiple simultaneous viral infections in infants with acute respiratory tract infections in Spain Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis Comparison of two multiplex methods for detection of respiratory viruses: FilmArray RP and xTAG keywords: detection; filmarray; pcr; respiratory; resplex; samples; time; viral; viruses cache: cord-307261-0a3iztns.txt plain text: cord-307261-0a3iztns.txt item: #277 of 427 id: cord-307874-0obomty2 author: Pardon, Bart title: Bovine Respiratory Disease Diagnosis: What Progress Has Been Made in Infectious Diagnosis? date: 2020-05-23 words: 7063 flesch: 37 summary: Mosby International Limited Rapid identification of mycoplasma bovis from bovine bronchoalveolar lavage fluid with MALDI-TOF MS after enrichment procedure Matrix-assisted laser desorption ionizationtime of flight mass spectrometry is a superior diagnostic tool for the identification and differentiation of Mycoplasmas isolated from animals Rapid identification of respiratory bacterial pathogens from bronchoalveolar lavage fluid in cattle by MALDI-TOF MS Rapid detection of tetracycline resistance in bovine Pasteurella multocida isolates by MALDI Biotyper antibiotic susceptibility test rapid assay Analysis of culture-dependent versus culture-independent techniques for identification of bacteria in clinically obtained bronchoalveolar lavage fluid Patterns of detection of respiratory viruses in nasal swabs from calves in Ireland: a retrospective study Pathogen-specific risk factors in acute outbreaks of respiratory disease in calves Bayesian estimation of pneumonia etiology: epidemiologic considerations and applications to the pneumonia etiology research for child health study Metagenomic characterization of the virome associated with bovine respiratory disease in feedlot cattle identified novel viruses and suggests an etiologic role for influenza D virus Respiratory viruses identified in western Canadian beef cattle by metagenomic sequencing and their association with bovine respiratory disease Modular approach to customise sample preparation procedures for viral metagenomics: a reproducible protocol for virome analysis Respiratory bacterial microbiota in cattle: from development to modulation to enhance respiratory health Multiplex PCR method for MinION and Illumina sequencing of Zika and other virus genomes directly from clinical samples Nanopore sequencing as a revolutionary diagnostic tool for porcine viral enteric disease complexes identifies porcine kobuvirus as an important enteric Nanopore metagenomics enables rapid clinical diagnosis of bacterial lower respiratory infection Mycoplasma bovis infections in cattle Transmission dynamics of Mycoplasma bovis in newly received beef bulls at fattening operations Detection by real-time RT-PCR of a bovine respiratory syncytial virus vaccine in calves vaccinated intranasally Characterization of Mannheimia haemolytica isolated from feedlot cattle that were healthy or treated for bovine respiratory disease Colonization and infection Variability in acquired resistance of Pasteurella and Mannheimia isolates from the nasopharynx of calves, with particular reference to different herd types Bacterial pathogens of the bovine respiratory disease complex Bioaerosols play a major role in the nasopharyngeal microbiota content in agricultural environment Effects of transportation to and co-mingling at an auction market on nasopharyngeal and tracheal bacterial communities of recently weaned beef cattle Quantitative bacterial cultures and cytological examination of bronchoalveolar lavage specimens in dogs Differential expression of sheep betadefensin-1 and -2 and interleukin 8 during acute Mannheimia haemolytica pneumonia Comparison of bronchoalveolar lavage fluid bacteriology and cytology in calves classified based on combined clinical scoring and lung ultrasonography Clinicopathological features of 11 suspected outbreaks of bovine adenovirus infection and development of a real-time quantitative PCR to detect bovine adenovirus type 10 Prevalence of respiratory pathogens in diseased, non-vaccinated, routinely medicated veal calves Bovine adenovirus type 3 pneumonia in dexamethasone-treated calves Apoptosis in calf pneumonia induced by endobronchial inoculation with bovine adenovirus type 3 (BAV-3) Structured literature review of responses of cattle to viral and bacterial pathogens causing bovine respiratory disease complex What is the evidence that bovine coronavirus is a biologically significant respiratory pathogen in cattle? A deep nasopharyngeal swab versus nonendoscopic bronchoalveolar lavage for isolation of bacterial pathogens from preweaned calves with respiratory disease Transmission dynamics of Mannheimia haemolytica in newly-received beef bulls at fattening operations A sequential broncho-alveolar washing in non-anaesthetized normal bovines: method and preliminary results Comparison of the nasopharyngeal bacterial microbiota of beef calves raised without the use of antimicrobials between healthy calves and those diagnosed with bovine respiratory disease Distinct bacterial metacommunities inhabit the upper and lower respiratory tracts of healthy feedlot cattle and those diagnosed with bronchopneumonia Use of deep nasopharyngeal swabs as a predictive diagnostic method for natural respiratory infections in calves The microbial flora of the respiratory tract in feedlot calves: associations between nasopharyngeal and bronchoalveolar lavage cultures Agreement among 4 sampling methods to identify respiratory pathogens in dairy calves with acute bovine respiratory disease Sample collection for diagnostics of bovine respiratory diseases Respiratory disease in calves: microbiological investigations on trans-tracheally aspirated bronchoalveolar fluid and acute phase protein response Collection and interpretation of tracheal wash and bronchoalveolar lavage for diagnosis of infectious and non-infectious lower airway disorders Factors associated with lung cytology as obtained by non-endoscopic broncho-alveolar lavage in grouphoused calves Effect of sedation on the intrapulmonary position of a bronchoalveolar lavage catheter in calves Influence of tilmicosin on quantified pulmonary concentrations of three bacterial pathogens in calves with naturallyoccurring bovine respiratory disease Mini-BAL, Blinded Bronchial Sampling, Blinded Protected Specimen Brush] to investigate for pulmonary infections, inflammation, and cellular and molecular markers: a narrative review Comparison of deep nasopharyngeal swab, bronchoalveolar lavage and transtracheal wash for the diagnosis of infectious bronchopneumonia in calves: which one is most animal friendly? keywords: animals; bovine; calves; cattle; culture; disease; pathogens; primary; results; sample; sampling; test; tract; use cache: cord-307874-0obomty2.txt plain text: cord-307874-0obomty2.txt item: #278 of 427 id: cord-308201-lavcsqov author: Desforges, Marc title: Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? date: 2019-12-20 words: 8478 flesch: 27 summary: These criteria certainly represent a pertinent tool to evaluate the involvement of human respiratory viruses as a factor that could influence long-term human neurological diseases. Nevertheless, our data suggest that HCoV-OC43 may also invade the CNS from the external environment through other pathways involving other cranial peripheral nerves [269] , reminiscent of what was shown for other human respiratory viruses such as RSV and influenza virus [8] . keywords: acute; cns; coronavirus; diseases; encephalitis; hcov; human; infection; influenza; mice; oc43; patients; respiratory; syndrome; system; term; tract; viruses cache: cord-308201-lavcsqov.txt plain text: cord-308201-lavcsqov.txt item: #279 of 427 id: cord-308979-qhlvd2mt author: Sumino, Kaharu C. title: Detection of Severe Human Metapneumovirus Infection by Real-Time Polymerase Chain Reaction and Histopathological Assessment date: 2005-09-15 words: 4301 flesch: 35 summary: Moreover, the prevalence and other characteristics of hMPV infection in the clinical setting of patients undergoing bronchoscopy for respiratory tract infections still need to be defined. In the present study, we add several critical pieces to the diagnostic and clinical matrix for hMPV infection: (1) we detected hMPV at a frequency similar to that of other respiratory tract viruses in patients who underwent bronchoscopy for suspected respiratory tract infection; (2) we quantitatively detected hMPV by real-time PCR in bronchoscopy samples from patients with severe respiratory tract illness but not in those without symptoms or signs of respiratory tract infection; (3) we used a viral culture system to develop a specific antisense probe for hMPV and then demonstrated hMPV mRNA in the lung tissue samples; and (4) we found organizing and acute lung injury and the prominent formation of smudge cells in the lung tissue samples of these patients, thereby suggesting that this pattern may be characteristic of hMPV infection. keywords: cells; hmpv; illness; infection; lung; patients; samples; tract; virus cache: cord-308979-qhlvd2mt.txt plain text: cord-308979-qhlvd2mt.txt item: #280 of 427 id: cord-309120-05bg7rfa author: Niazi, Sadegh title: The role of respiratory droplet physicochemistry in limiting and promoting the airborne transmission of human coronaviruses: A critical review() date: 2020-11-06 words: 2718 flesch: 7 summary: Report for 940 the World Health Organization Liquid-liquid phase separation in 942 organic particles containing one and two organic species: importance of the average 943 O : C Exhalation of respiratory viruses by breathing, coughing, and talking Biodefense research methodology and animal models An initial investigation of the association 949 between the SARS outbreak and weather: with the view of the environmental temperature and its 950 variation Review of aerosol transmission of influenza A virus Numerical Study of Particle Deposition in Bends of a Circular Cross-954 Section-Laminar Flow Regime Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1 Stability of Middle East respiratory 960 syndrome coronavirus (MERS-CoV) under different environmental conditions Physico-chemical characteristics of evaporating respiratory fluid 962 droplets Physico-chemical characteristics of evaporating respiratory fluid 964 droplets Cough-generated aerosols of Pseudomonas aeruginosa and other Gram-negative bacteria from 968 patients with cystic fibrosis Factors affecting the viability of air-borne bacteria. Coronavirus Contamination in 811 Air and Surrounding Environment in MERS Isolation Wards The nucleus in and the growth of hygroscopic droplets Environmental Persistence of Influenza Viruses Is Dependent upon Virus Type and Host Origin Low 817 ambient humidity impairs barrier function and innate resistance against influenza infection Transmission of influenza A in human beings Role of ventilation in airborne transmission of infectious agents in the built environment-a 823 multidisciplinary systematic review Electron cryotomography of 825 measles virus reveals how matrix protein coats the ribonucleocapsid within intact virions Humidity-Dependent Decay of Viruses, but Not Bacteria Droplets Follows Disinfection Kinetics Environmental factors on the SARS epidemic: 830 air temperature, passage of time and multiplicative effect of hospital infection Probing the structure of the 833 SARS coronavirus using scanning electron microscopy Measurements of airborne influenza virus in aerosol particles 836 from human coughs Measurements of airborne influenza virus in 839 aerosol particles from human coughs Viable influenza keywords: air; droplets; human; humidity; influenza; sars; transmission; virus cache: cord-309120-05bg7rfa.txt plain text: cord-309120-05bg7rfa.txt item: #281 of 427 id: cord-310508-zgqbfmzl author: Alavi-Moghaddam, Mostafa title: A Novel Coronavirus Outbreak from Wuhan City in China, Rapid Need for Emergency Departments Preparedness and Response; a Letter to Editor date: 2020-02-02 words: 1259 flesch: 40 summary: The severe disease manifests as severe acute respiratory infection (SARI) or severe pneumonia, Acute Respiratory Distress Syndrome (ARDS), sepsis and septic shock. World Health Organization Infection prevention and control during health care when novel coronavirus ( nCoV) infection is suspected: interim guidance Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected: interim guidance keywords: coronavirus; infection; ncov; patients cache: cord-310508-zgqbfmzl.txt plain text: cord-310508-zgqbfmzl.txt item: #282 of 427 id: cord-311275-ysr9nqun author: Chuaychoo, Benjamas title: Clinical manifestations and outcomes of respiratory syncytial virus infection in adult hospitalized patients date: 2019-07-03 words: 3167 flesch: 38 summary: key: cord-311275-ysr9nqun authors: Chuaychoo, Benjamas; Ngamwongwan, Sopita; Kaewnaphan, Bualan; Athipanyasilp, Niracha; Horthongkham, Navin; Kantakamalakul, Wannee; Muangman, Nisa title: Clinical manifestations and outcomes of respiratory syncytial virus infection in adult hospitalized patients date: 2019-07-03 journal: J Clin Virol DOI: 10.1016/j.jcv.2019.07.001 sha: doc_id: 311275 cord_uid: ysr9nqun BACKGROUND: Respiratory syncytial virus (RSV) is an important virus found in adult hospitalized patients. There were a few data of adult hospitalized patients with RSV infection, with high complications, in Thailand; [3, 12, 13] however, additional clinical data are required for planning patient management and also disease prevention in this region. keywords: acute; adult; infection; patients; pneumonia; rsv; virus cache: cord-311275-ysr9nqun.txt plain text: cord-311275-ysr9nqun.txt item: #283 of 427 id: cord-312024-qdgqif5j author: Talbot, H. Keipp title: The Diagnosis of Viral Respiratory Disease in Older Adults date: 2010-02-01 words: 3426 flesch: 35 summary: The increasing availability of new rapid and sensitive molecular diagnostics such as polymerase chain reaction testing, should provide more accurate and timely diagnoses of viral respiratory infections in older adults in the near future. Because viral respiratory infections in older adults represent reinfection, a single serum sample to detect viral specific immunoglobulin G is not useful for diagnosis. keywords: adults; culture; diagnosis; infection; influenza; pcr; virus cache: cord-312024-qdgqif5j.txt plain text: cord-312024-qdgqif5j.txt item: #284 of 427 id: cord-312613-1nl7q6cy author: Luz Garcia-Garcia, M. title: Pediatric Asthma and Viral Infection() date: 2016-03-26 words: 4095 flesch: 34 summary: Asthma in the United States: burden and current theories Epidemiology of asthma: prevalence and burden of disease Community study of role of viral infections in exacerbations of asthma in 9-11 year old children Frequent detection of human rhinoviruses, paramyxoviruses, coronaviruses, and bocavirus during acute respiratory tract infections Role of emerging respiratory viruses in children with severe acute wheezing Hospitalizations and outpatient visits for rhinovirus-associated acute respiratory illness in adults The role of respiratory virus infections in childhood asthma inception Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens What's in the name? A cohort study Preschool asthma after bronchiolitis in infancy The outcome after severe bronchiolitis is related to gender and virus A novel group of rhinoviruses is associated with asthma hospitalizations Rhinovirus illnesses during infancy predict subsequent childhood wheezing Wheezing rhinovirus illnesses in early life predict asthma development in highrisk children Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma Rhinovirus bronchiolitis and recurrent wheezing: 1-year follow-up Adolescent asthma after rhinovirus and respiratory syncytial virus bronchiolitis A newly discovered human pneumovirus isolated from young children with respiratory tract disease Human metapneumovirus bronchiolitis in infancy is an important risk factor for asthma at age 5 Cloning of a human parvovirus by molecular screening of respiratory tract samples Recurrent wheezing and asthma after bocavirus bronchiolitis The effect of respiratory syncytial virus on subsequent recurrent wheezing in atopic and nonatopic children Causal direction between respiratory syncytial virus bronchiolitis and asthma studied in monozygotic twins Neonatal bronchial hyperresponsiveness precedes acute severe viral bronchiolitis in infants Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life Detection of new respiratory viruses in hospitalized infants with bronchiolitis: a three-year prospective study Influence of maternal asthma on the cause and severity of infant acute respiratory tract infections keywords: age; asthma; bronchiolitis; children; infections; rhinovirus; risk; rsv; wheezing; years cache: cord-312613-1nl7q6cy.txt plain text: cord-312613-1nl7q6cy.txt item: #285 of 427 id: cord-312615-q333qgps author: Knobbe, Rebecca B title: Pathogens Causing Respiratory Tract Infections in Children Less Than 5 Years of Age in Senegal date: 2019-12-30 words: 4469 flesch: 46 summary: A prospective observational study in four Indian hospitals Antimicrobial resistance: a global multifaceted phenomenon Antibiotic resistance threats in the United States Childhood pneumonia: the role of viruses Burden of disease caused by Haemophilus influenzae type b in children younger than 5 years: global estimates Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates Burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in the era of conjugate vaccines: global, regional, and national estimates for 2000-15 Invasive disease potential of pneumococci before and after the 13-valent pneumococcal conjugate vaccine implementation in children Children under five years of age in Senegal: a group highly exposed to respiratory viruses infections Viral and bacterial etiologies of acute respiratory infections among children under 5 years in Senegal Enteroviruses and rhinoviruses: molecular epidemiology of the most influenza-like illness associated viruses in Senegal Community-acquired pneumonia in children -a changing spectrum of disease Respiratory viruses detected in Mexican children younger than 5 years old with communityacquired pneumonia: a national multicenter study Microorganisms associated with pneumonia in children <5 years of age in developing and emerging countries: the GABRIEL pneumonia multicenter, prospective, case-control study Viral and bacterial causes of severe acute respiratory illness among children aged less than 5 years in a high malaria prevalence area of Western Kenya Aetiology of childhood pneumonia in a well vaccinated South African birth cohort: a nested case-control study of the Drakenstein Child Health Study Association of respiratory viruses with outcomes of severe childhood pneumonia in Botswana A preliminary study of pneumonia etiology among hospitalized children in Kenya Etiology and factors associated with pneumonia in children under 5 years of age in Mali: a prospective case-control study National Health Care Provider Solutions. Provider Handbook The utility of serum C-reactive protein in differentiating bacterial from nonbacterial pneumonia in children: a meta-analysis of 1230 children Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review A flexible statistical power analysis program for the social, behavioral, and biomedical sciences Nucleic acid amplification tests for the diagnosis of pneumonia Moraxella catarrhalis, a human respiratory tract pathogen Community-acquired pneumonia requiring hospitalization among U.S. Children Serotype replacement in disease following pneumococcal vaccination: a discussion of the evidence Multi-site and nasal swabbing for carriage of Staphylococcus aureus: what does a single nose swab predict Detection of non-influenza viruses in acute respiratory infections in children under fie-year-old in Cote d'Ivoire Viral etiology of respiratory tract infections in children at the paediatric hospital in Ouagadougou (Burkina Faso) Seasonal variations of respiratory viruses and etiology of human rhinovirus infection in children keywords: age; cases; children; controls; infections; pathogens; pneumonia; study; viruses; years cache: cord-312615-q333qgps.txt plain text: cord-312615-q333qgps.txt item: #286 of 427 id: cord-312691-ynh84b98 author: Mohd, Hamzah A. title: Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia date: 2016-09-24 words: 3297 flesch: 47 summary: Kingdom of Saudi Arabia: Ministry of Health (MOH) Evidence for camel-to-human transmission of MERS coronavirus Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels Middle East Respiratory Syndrome Coronavirus neutralizing serum antibodies in dromedary camels: a comparative serological study Antibodies against MERS coronavirus in dromedary camels Middle East Respiratory Syndrome Coronavirus infection in dromedary camels in Saudi Arabia Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia An observational, laboratory-based study of outbreaks of Middle East Respiratory Syndrome coronavirus in Jeddah and Riyadh, kingdom of Saudi Arabia Hospital-associated outbreak of Middle East Respiratory Syndrome Coronavirus: a serologic, epidemiologic, and clinical description Hospital outbreak of Middle East Respiratory Syndrome Coronavirus Synthesizing data and models for the spread of MERS-CoV, 2013: key role of index cases and hospital transmission Middle East Respiratory Syndrome Coronavirus: a case-control study of hospitalized patients Clinical aspects and outcomes of 70 patients with Middle East Respiratory Syndrome Coronavirus infection: a singlecenter experience in Saudi Arabia Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East Respiratory Syndrome Coronavirus disease from Saudi Arabia: a descriptive study Infection prevention and control guidelines for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection Imported cases of Middle East Respiratory Syndrome: an update Travel implications of emerging coronaviruses: SARS and MERS-CoV Middle East Respiratory Syndrome Coronavirus: current situation and travelassociated concerns Presence of Middle East Respiratory Syndrome Coronavirus antibodies in Saudi Arabia: a nationwide, crosssectional, serological study An adult returned traveler from Dubai hospitalized with an influenzalike illness (ILI): Middle East Respiratory Syndrome (MERS) or influenza? Infection control implications from a Near MERS case Middle East Respiratory Syndrome (MERS): a zoonotic viral pneumonia Serial intervals of respiratory infectious diseases: a systematic review and analysis Cluster of Middle East Respiratory Syndrome coronavirus infections in Iran None of the authors declared COI. keywords: coronavirus; cov; east; infection; mers; patients; syndrome cache: cord-312691-ynh84b98.txt plain text: cord-312691-ynh84b98.txt item: #287 of 427 id: cord-312741-0au4nctt author: Lin, Panpan title: Coronavirus in human diseases: Mechanisms and advances in clinical treatment date: 2020-10-01 words: 14692 flesch: 30 summary: The 9-kDa hydrophobic protein encoded at the 3' end of the porcine transmissible gastroenteritis coronavirus genome is membrane-associated Mouse hepatitis virus gene 5b protein is a new virion envelope protein Infectious bronchitis virus E protein is targeted to the Golgi complex and directs release of virus-like particles A comprehensive comparison of transmembrane domains reveals organelle-specific properties Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein Induction of apoptosis in murine coronavirus-infected cultured cells and demonstration of E protein as an apoptosis inducer Assembly of the coronavirus envelope: homotypic interactions between the M proteins SARS coronavirus E protein forms cation-selective ion channels Differential maturation and subcellular localization of severe acute respiratory syndrome coronavirus surface proteins S, M and E Bcl-xL inhibits T-cell apoptosis induced by expression of SARS coronavirus E protein in the absence of growth factors The transmembrane domain of the infectious bronchitis virus E protein is required for efficient virus release Biochemical evidence for the presence of mixed membrane topologies of the severe acute respiratory syndrome coronavirus envelope protein expressed in mammalian cells Role of the coronavirus E viroporin protein transmembrane domain in virus assembly Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis Heterologous gene expression from transmissible gastroenteritis virus replicon particles Generation of a replication-competent, propagation-deficient virus vector based on the transmissible gastroenteritis coronavirus genome The small envelope protein E is not essential for murine coronavirus replication A severe acute respiratory syndrome coronavirus that lacks the E gene is attenuated in vitro and in vivo Absence of E protein arrests transmissible gastroenteritis coronavirus maturation in the secretory pathway Characterization of severe acute respiratory syndrome coronavirus membrane protein Sequence and topology of a model intracellular membrane protein, E1 glycoprotein, from a coronavirus Genetic evidence for a structural interaction between the carboxy termini of the membrane and nucleocapsid proteins of mouse hepatitis virus The molecular biology of coronaviruses A structural analysis of M protein in coronavirus assembly and morphology Envelope glycoprotein interactions in coronavirus assembly Efficient assembly and release of SARS coronavirus-like particles by a heterologous expression system Coronaviruses: an overview of their replication and pathogenesis Nucleocapsidindependent assembly of coronavirus-like particles by co-expression of viral envelope protein genes Coronavirus pseudoparticles formed with recombinant M and E proteins induce alpha interferon synthesis by leukocytes The cytoplasmic tails of infectious bronchitis virus E and M proteins mediate their interaction The missing link in coronavirus assembly. syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization Identification of in vivointeracting domains of the murine coronavirus nucleocapsid protein Glycogen synthase kinase-3 regulates the phosphorylation of severe acute respiratory syndrome coronavirus nucleocapsid protein and viral replication Oligomerization of the carboxyl terminal domain of the human coronavirus 229E nucleocapsid protein Solution structure of the c-terminal dimerization domain of SARS coronavirus nucleocapsid protein solved by the SAIL-NMR method High affinity interaction between nucleocapsid protein and leader/intergenic sequence of mouse hepatitis virus RNA The nucleocapsid protein of SARS coronavirus has a high binding affinity to the human cellular heterogeneous nuclear ribonucleoprotein A1 Theoretical aspects of virus capsid assembly Analysis of multimerization of the SARS coronavirus nucleocapsid protein Mass spectroscopic characterization of the coronavirus infectious bronchitis virus nucleoprotein and elucidation of the role of phosphorylation in RNA binding by using surface plasmon resonance Mapping of the coronavirus membrane protein domains involved in interaction with the spike protein Envelope protein palmitoylations are crucial for murine coronavirus assembly The hydrophobic domain of infectious bronchitis virus E protein alters the host secretory pathway and is important for release of infectious virus The coronavirus E protein: assembly and beyond Mouse hepatitis virus replicase proteins associate with two distinct populations of intracellular membranes The intracellular sites of early replication and budding of SARS-coronavirus Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer Glycan shield and epitope masking of a coronavirus spike protein observed by cryoelectron microscopy Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains A human homolog of angiotensin-converting enzyme. keywords: binding; cells; coronavirus; cov; covid-19; covs; domain; east; entry; fusion; host; human; infection; inhibitors; membrane; mers; middle; novel; patients; protein; receptor; replication; rna; sars; sars coronavirus; spike; syndrome; syndrome coronavirus; treatment cache: cord-312741-0au4nctt.txt plain text: cord-312741-0au4nctt.txt item: #288 of 427 id: cord-312797-hohzjx74 author: Hamelin, Marie-Ève title: Human Metapneumovirus: A New Player among Respiratory Viruses date: 2004-04-01 words: 3363 flesch: 38 summary: In addition, we found that outbreaks of hMPV infection tend to peak in early spring over a 4-6 week period, slightly later than outbreaks of hRSV infection, which also are more spread out in time [19] . However, additional studies over multiple years are needed to better define the seasonality of hMPV infection. keywords: children; hmpv; hrsv; human; infection; metapneumovirus; studies; tract cache: cord-312797-hohzjx74.txt plain text: cord-312797-hohzjx74.txt item: #289 of 427 id: cord-312928-ef8hqs4s author: Chavanet, Pascal title: Viral Upper Respiratory Tract Infection and Otitis Media Complication in Young Children date: 2008-03-15 words: 591 flesch: 37 summary: Indeed, in this study, the rate of respiratory syncitial virus infection was found to be low, probably as a result of the method used (conventional assays, type of molecular technique, RT-PCR vs. microarray, etc). They found that 63% of children were virus positive and concluded that the rate of otitis media complication was 61% (37% for acute otitis media and 24% for otitis media with effusion), that these risks decrease as the age increases, and that adenovirus, coronavirus, and respiratory syncitial virus represent more than two-thirds of otitis media complications. keywords: children; otitis cache: cord-312928-ef8hqs4s.txt plain text: cord-312928-ef8hqs4s.txt item: #290 of 427 id: cord-312952-9gbb4own author: WARDZYŃSKA, ALEKSANDRA title: The profile of respiratory pathogens in induced sputum of elderly and non-elderly asthmatics date: 2020-01-20 words: 2992 flesch: 42 summary: This technique was chosen for the present study, to test the hypothesis that elderly patients with asthma display a different profile of respiratory pathogens in the airways as compared to non-elderly asthmatics, and that this profile may be related to local airway and/or systemic inflammation. The presence of Influenza A virus in the airways of stable asthma patients (without any clinical signs of infection) was associated with lower respiratory function and RSV B with a lower percentage of lymphocytes in the IS. keywords: asthma; asthmatics; pathogens; patients; presence; sputum; study; viruses cache: cord-312952-9gbb4own.txt plain text: cord-312952-9gbb4own.txt item: #291 of 427 id: cord-313749-f2ct57em author: Brittain-Long, Robin title: Multiplex real-time PCR for detection of respiratory tract infections date: 2007-12-26 words: 1568 flesch: 40 summary: Diagnosis of viral respiratory tract infections using viral culture, antigen detection or serology is either too slow or too insensitive to be applicable in clinical practice (Gunson et al., 2005) . Development of three multiplex RT-PCR assays for the detection of 12 respiratory RNA viruses Aetiological role of viral and bacterial infections in acute adult lower respiratory tract infection (LRTI) in primary care Etiology of community-acquired pneumonia in hospitalized patients in Chile: the increasing prevalence of respiratory viruses among classic pathogens Practical implementation of a multiplex PCR for acute respiratory tract infections in children Real-time RT-PCR detection of 12 respiratory viral infections in four triplex reactions Pring-Akerblom P. Rapid and quantitative detection of human adenovirus DNA by real-time PCR Comparison of real-time PCR assays with fluorescent-antibody assays for diagnosis of respiratory virus infections in children Simultaneous detection and high-throughput identification of a panel of RNA viruses causing respiratory tract infections Comparison of a multiplex reverse transcription-PCR-enzyme hybridization assay with conventional viral culture and immunofluorescence techniques for the detection of seven viral respiratory pathogens Antibiotic prescribing in outpatients: a 1-week diagnosis-prescribing study in 5 counties in Sweden Evaluation of a multiplex reverse transcriptase PCR ELISA for the detection of nine respiratory tract pathogens Rapid and sensitive method using multiplex real-time PCR for diagnosis of infections by influenza A and influenza B viruses, respiratory syncytial virus, and parainfluenza viruses 1, 2, 3, and 4 Design and performance testing of quantitative real-time PCR assays for influenza A and B viral load measurement Real-time quantitative PCR assays for detection and monitoring of pathogenic human viruses in immunosuppressed pediatric patients We are grateful to Dr Lars Nielsen, Copenhagen, for sharing experience, oligonucleotide sequences and samples. keywords: infections; pcr; time cache: cord-313749-f2ct57em.txt plain text: cord-313749-f2ct57em.txt item: #292 of 427 id: cord-314190-fvdock94 author: Florin, Todd A title: Viral bronchiolitis date: 2017-01-01 words: 7587 flesch: 30 summary: Viral bronchiolitis in children Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells Nasal mucociliary transport in healthy subjects is slower when breathing dry air Altitude and environmental climate eff ects on bronchiolitis severity among children presenting to the emergency department The relationship of meteorological conditions to the epidemic activity of respiratory syncytial virus Air pollution and acute respiratory infections among children 0-4 years of age: a 1-8 year time-series study Air pollution interacts with past episodes of bronchiolitis in the development of asthma Exposure to traffi c and early life respiratory infection: a cohort study Systematic literature review assessing tobacco smoke exposure as a risk factor for serious respiratory syncytial virus disease among infants and young children Severity of respiratory syncytial virus bronchiolitis is aff ected by cigarette smoke exposure and atopy Respiratory syncytial virus-associated hospitalizations among infants and young children in the United States Respiratory syncytial virus-associated hospitalizations among children less than 24 months of age Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite eff ect in boys and girls Kendig and Chernick's disorders of the respiratory tract in children Pathological changes in virus infections of the lower respiratory tract in children Bronchiolitis: lingering questions about its defi nition and the potential role of vitamin D Detection of new respiratory viruses in hospitalized infants with bronchiolitis: a three-year prospective study Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants In very young infants severity of acute bronchiolitis depends on carried viruses Viral etiologies of infant bronchiolitis, croup and upper respiratory illness during 4 consecutive years Virus type and genomic load in acute bronchiolitis: severity and treatment response with inhaled adrenaline Prospective multicenter study of the viral etiology of bronchiolitis in the emergency department Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis Respiratory syncytial virus genomic load and disease severity among children hospitalized with bronchiolitis: multicenter cohort studies in the United States and Finland Evaluation of viral load in infants hospitalized with bronchiolitis caused by respiratory syncytial virus Association of rhinovirus infection with increased disease severity in acute bronchiolitis Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis Frequent detection of respiratory viruses without symptoms: toward defi ning clinically relevant cutoff values Detection of respiratory syncytial virus and rhinovirus in healthy infants Respiratory viral detection in children and adults: comparing asymptomatic controls and patients with community-acquired pneumonia Bronchiolitis in children: diagnosis and management. Nasal irrigation with saline solution signifi cantly improves oxygen saturation in infants with bronchiolitis Decreasing unnecessary utilization in acute bronchiolitis care: results from the value in inpatient pediatrics network Eff ectiveness of chest physiotherapy in infants hospitalized with acute bronchiolitis: a multicenter, randomized, controlled trial Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old Acute bronchiolitis: predisposing factors and characterization of infants at risk Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the fi rst year of life Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years Acute bronchiolitis in infancy as risk factor for wheezing and reduced pulmonary function by seven years in Akershus County A longitudinal study on early hospitalized airway infections and subsequent childhood asthma The severity-dependent relationship of infant bronchiolitis on the risk and morbidity of early childhood asthma Saline in acute bronchiolitis RCT and economic evaluation: hypertonic saline in acute bronchiolitis-randomised controlled trial and systematic review Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. keywords: bronchiolitis; children; evidence; hospital; hypertonic; infants; infection; length; oxygen; risk; saline; stay; studies; trial; virus cache: cord-314190-fvdock94.txt plain text: cord-314190-fvdock94.txt item: #293 of 427 id: cord-314841-b5l6epy3 author: Falsey, Ann Regina title: Respiratory viral infections date: 2019-08-15 words: 6010 flesch: 26 summary: Nasopharyngeal microbiota, host transcriptome, and disease severity in children with respiratory syncytial virus infection Patient-based transcriptome-wide analysis identify interferon and ubiquination pathways as potential predictors of influenza A disease severity Gene expression profiles during in vivo human rhinovirus infection: insights into the host response A genomic signature of influenza infection shows potential for presymptomatic detection, guiding early therapy, and monitoring clinical responses Influenza infection and risk of acute myocardial infarction in England and Wales: a CALIBER self-controlled case series study Acute myocardial infarction after laboratory-confirmed influenza infection Effect of influenza on functional decline A study of the impact of influenza on the functional status of frail older people Gene expression profiles link respiratory viral infection, platelet response to aspirin, and acute myocardial infarction The current epidemiology and clinical decisions surrounding acute respiratory infections Gene expression signatures diagnose influenza and other symptomatic respiratory viral infections in humans A distinct influenza infection signature in the blood transcriptome of patients with severe communityacquired pneumonia Appropriate antibiotic use for acute respiratory tract infection in adults Treating viral respiratory tract infections with antibiotics in hospitals: no longer a case of mistaken identity Bacterial complications of respiratory tract viral illness: a comprehensive evaluation Routine molecular point-of-care testing for respiratory viruses in adults presenting to hospital with acute respiratory illness (ResPOC): a pragmatic, open-label, randomised controlled trial Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia Developing molecular amplification methods for rapid diagnosis of respiratory tract infections caused by bacterial pathogens Assessing the human immune system through blood transcriptomics Superiority of transcriptional profiling over procalcitonin for distinguishing bacterial from viral lower respiratory tract infections in hospitalized adults Gene expression patterns in blood leukocytes discriminate patients with acute infections Gene expression profiles in febrile children with defined viral and bacterial infection Robust classification of bacterial and viral infections via integrated host gene expression diagnostics Host gene expression classifiers diagnose acute respiratory illness etiology Transcriptomic biomarkers to discriminate bacterial from nonbacterial infection in adults hospitalized with respiratory illness Diagnostic test accuracy of a 2-transcript host RNA signature for discriminating bacterial vs viral infection in febrile children Association of RNA biosignatures with bacterial infections in febrile infants aged 60 days or younger A host-based RT-PCR gene expression signature to identify acute respiratory viral infection Detection of host response to viral respiratory infection by measurement of messenger RNA for MxA, TRIM21, and viperin in nasal swabs Analysis of the host transcriptional response during respiratory viral infection using in-vitro, animal models and natural and experimental human challenge have furthered the understanding of the mechanisms and predictors of severe disease and may identify potential therapeutic targets to prevent and ameliorate illness. keywords: children; disease; expression; gene; host; hrv; human; infection; influenza; response; studies; viral; virus; viruses cache: cord-314841-b5l6epy3.txt plain text: cord-314841-b5l6epy3.txt item: #294 of 427 id: cord-315037-lmur80te author: Lin, Chien-Yu title: Increased Detection of Viruses in Children with Respiratory Tract Infection Using PCR date: 2020-01-15 words: 4192 flesch: 37 summary: Systematic review and meta-analysis The clinical significance of filmarray respiratory panel in diagnosing community-acquired pneumonia Comparison of real-time pcr assays with fluorescent-antibody assays for diagnosis of respiratory virus infections in children Rapid and sensitive method using multiplex real-time pcr for diagnosis of infections by influenza a and influenza b viruses, respiratory syncytial virus, and parainfluenza viruses 1, 2, 3, and 4 Public health responses to reemergence of animal rabies Frequent detection of viral coinfection in children hospitalized with acute respiratory tract infection using a real-time polymerase chain reaction An economical tandem multiplex real-time pcr technique for the detection of a comprehensive range of respiratory pathogens Real-time reverse transcriptase pcr assay for detection of human metapneumoviruses from all known genetic lineages Design and performance testing of quantitative real time pcr assays for influenza a and b viral load measurement Simultaneous detection of influenza a, influenza b, and respiratory syncytial viruses and subtyping of influenza a h3n2 virus and h1n1 (2009) virus by multiplex real-time pcr Rapid testing for respiratory syncytial virus in a paediatric emergency department: Benefits for infection control and bed management Viral respiratory tract infections in allogeneic hematopoietic stem cell transplantation recipients in the era of molecular testing The use of antimicrobial agents after diagnosis of viral respiratory tract infections in hospitalized adults: Antibiotics or anxiolytics? Antimicrobial drug prescription in ambulatory care settings, united states Antibiotics for bronchiolitis in children Reducing unnecessary chest x-rays, antibiotics and bronchodilators through implementation of the nice bronchiolitis guideline Viral etiology of acute lower respiratory tract infections in hospitalized young children in northern Taiwan Respiratory viral infections detected by multiplex pcr among pediatric patients with lower respiratory tract infections seen at an urban hospital in delhi from Etiologic spectrum and occurrence of coinfections in children hospitalized with community-acquired pneumonia Respiratory virus of severe pneumonia in south korea: Prevalence and clinical implications Differential risk of hospitalization among single virus infections causing influenza like illnesses Epidemiological study of hospitalization associated with respiratory syncytial virus infection in Taiwanese children between Prolonged seasonality of respiratory syncytial virus infection among preterm infants in a subtropical climate Global respiratory syncytial virus-associated mortality in young children (rsv gold): A retrospective case series Epidemiology and clinical characteristics of community-acquired pneumonia in hospitalized children Etiology and impact of coinfections in children hospitalized with community-acquired pneumonia Table S2 A newly discovered human pneumovirus isolated from young children with respiratory tract disease Identification of a new human coronavirus Community-acquired pneumonia requiring hospitalization among US Children Viral pneumonia Community-acquired pneumonia requiring hospitalization among US Respiratory viral infections during the first 28 days after transplantation in pediatric hematopoietic stem cell transplant recipients Unrecognized viral respiratory tract infections in premature infants during their birth hospitalization: A prospective surveillance study in two neonatal intensive care units Implementation of rapid diagnostics with antimicrobial stewardship The role of multiplex pcr in respiratory tract infections in children Early diagnosis of lower respiratory tract infections (point-of-care tests) Etiological diagnosis reduces the use of antibiotics in infants with bronchiolitis Casas, I. Spectrum of respiratory viruses in children with community-acquired pneumonia Resisting the use of antibiotics for viral infections Diagnostic value of respiratory virus detection in symptomatic children using real-time pcr Are we ready for novel detection methods to treat respiratory pathogens in hospital-acquired pneumonia? Multiplex pcr system for the rapid diagnosis of respiratory virus infection: keywords: children; detection; infection; pcr; rsv; specimens; tests; viruses cache: cord-315037-lmur80te.txt plain text: cord-315037-lmur80te.txt item: #295 of 427 id: cord-315339-dcui85lw author: Broadbent, Andrew J. title: Respiratory Virus Vaccines date: 2015-03-13 words: 28291 flesch: 26 summary: Type I interferons keep activated T cells alive A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a phase I clinical trial Antigenic structure of the human respiratory syncytial virus G glycoprotein and relevance of hypermutation events for the generation of antigenic variants The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta Subcellular localization of Toll-like receptor 3 in human dendritic cells The functional heterogeneity of type 1 effector T cells in response to infection is related to the potential for IFNgamma production AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people Regulation of IgA synthesis and immune response by T cells and interleukins Innate immune control and regulation of influenza virus infections IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells Memory CD4 + T cells protect against influenza through multiple synergizing mechanisms Structure of respiratory syncytial virus fusion glycoprotein in the postfusion conformation reveals preservation of neutralizing epitopes The human cytotoxic T cell response to influenza A vaccination Adaptive strategies of the influenza virus polymerase for replication in humans Live attenuated influenza vaccine induces cross-reactive antibody responses in children against an a/Fujian/411/2002-like H3N2 antigenic variant strain Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response Intestinal IgA: novel views on its function in the defence of the largest mucosal surface The influence of HIV infection on antibody responses to a two-dose regimen of influenza vaccine Human genetic factors and respiratory syncytial virus disease severity Oral immunization with influenza virus in biodegradable microspheres Human immune responses to influenza virus vaccines administered by systemic or mucosal routes Respiratory syncytial virus synergizes with Th2 cytokines to induce optimal levels of TARC/CCL17 Comparative efficacy of inactivated and live attenuated influenza vaccines Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude ISCOM, a delivery system for parenteral and mucosal vaccination Adjuvant system AS03 containing alpha-tocopherol modulates innate immune response and leads to improved adaptive immunity H5N1 influenza vaccine formulated with AS03 A induces strong crossreactive and polyfunctional CD4 T-cell responses Roles of CD4 + T-cell-independent and -dependent antibody responses in the control of influenza virus infection: evidence for noncognate CD4 + T-cell activities that enhance the therapeutic activity of antiviral antibodies Antigenicity and immunogenicity of equine influenza vaccines containing a carbomer adjuvant The molecular basis of the pathogenicity of the Dutch highly pathogenic human influenza A H7N7 viruses Formalin-inactivated respiratory syncytial virus vaccine induces antibodies to the fusion glycoprotein that are deficient in fusion-inhibiting activity Association of serum anti-neuraminidase antibody with resistance to influenza in man Pathological study of archival lung tissues from five fatal cases of avian H5N1 influenza in Vietnam Systems biology of vaccination for seasonal influenza in humans Alum-adjuvanted H5N1 whole virion inactivated vaccine (WIV) induced IgG1 and IgG4 antibody responses in young children Mucosal vaccines: the promise and the challenge Influenza virus-infected epithelial cells present viral antigens to antigen-specific CD8 + cytotoxic T lymphocytes Gamma interferon is not required for mucosal cytotoxic T-lymphocyte responses or heterosubtypic immunity to influenza A virus infection in mice Heterosubtypic immunity to influenza A virus infection requires B cells but not CD8 + cytotoxic T lymphocytes Heterosubtypic immunity to influenza A virus infection requires a properly diversified antibody repertoire A novel M cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigenspecific immune responses A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells Endogenous naive CD8 + T cell precursor frequency regulates primary and memory responses to infection Vaccination strategies for mucosal immune responses Recent developments in adjuvants for vaccines against infectious diseases Prevention of antigenically drifted influenza by inactivated and live attenuated vaccines Prevention of symptomatic seasonal influenza in 2005-2006 by inactivated and live attenuated vaccines Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains Protection against the mouse-adapted A/FM/1/47 strain of influenza A virus in mice by a monoclonal antibody with cross-neutralizing activity among H1 and H2 strains Efficacy and effectiveness of influenza vaccines: a systematic review and metaanalysis Effect of priming with H1N1 influenza viruses of variable antigenic distances on challenge with 2009 pandemic H1N1 virus Orthomyxoviridae: the viruses and their replication The majority of studies evaluating respiratory virus vaccines measure serum antibody responses, because, although both cellular and humoral responses contribute to the clearance of a primary infection, neutralizing antibodies are known to protect against secondary infection. keywords: addition; antibodies; antibody; antibody responses; antigen; cd4; cd8; cell responses; cells; challenge; children; disease; et al; host; human; iga; immune; immunity; infection; influenza; influenza infection; influenza vaccines; influenza virus; live; mice; mucosal; protection; protein; replication; responses; rsv; sars; serum; specific; syncytial; t cells; tract; type; vaccination; vaccine; virus; virus infection; virus vaccine; viruses cache: cord-315339-dcui85lw.txt plain text: cord-315339-dcui85lw.txt item: #296 of 427 id: cord-315598-qwh72inx author: Mendoza, Jose Luis Accini title: ACTUALIZACION DE LA DECLARACIÓN DE CONSENSO EN MEDICINA CRITICA PARA LA ATENCIÓN MULTIDISCIPLINARIA DEL PACIENTE CON SOSPECHA O CONFIRMACIÓN DIAGNÓSTICA DE COVID-19 date: 2020-10-06 words: 69660 flesch: 31 summary: y los que tienen menos probabilidades de beneficiarse (él «demasiado enfermo»), no prestan suficiente atención a las diferencias entre grupos en términos de la duración de los cuidados intensivos necesarios para lograr resultados. Se recomienda aplicar la escala SOFA al menos cada 48 horas sumado al criterio de fragilidad y años de vida saludables salvados estos criterios podrían ser válidos en pacientes con fallo terapéutico a las medidas óptimas y orientar decisiones de deescalamiento de medidas y de nivel de complejidad de atención cuando la demanda potencial supera la oferta (capacidad y capacidades), estas decisiones deben ser tomadas idealmente en junta médica. keywords: 2019; 2020; acuerdo con; acute; además de; aguda; alto; amci; analysis; análisis de; asociado con; aumento de; bajo; calidad de; care; casos de; clinical; clínica; clínica de; clínicos; comité de; como el; como la; como los; como se; como una; compromiso; con covid-19; con el; con enfermedad; con hipoxemia; con infección; con la; con los; con mayor; con neumonía; con que; con sars; con sdra; con sospecha; con su; con un; condiciones de; considerar la; contar con; contra; control; coronavirus; cov-2; criterios de; crítico con; cual se; cuando se; cuenta la; de acuerdo; de aerosoles; de alta; de amci; de atención; de baja; de cada; de contaminación; de coronavirus; de covid-19; de cuidados; de de; de dificultad; de enfermedad; de esta; de estos; de estudios; de falla; de forma; de hcq; de hipoxemia; de il-6; de infección; de ingreso; de intubación; de la; de los; de manera; de marzo; de menor; de oxígeno; de pacientes; de protección; de salud; de ser; de soporte; de su; de tórax; de un; de ventilación; de vida; deben; del; del virus; dentro; desde el; después de; diagnóstico de; disease; disminución de; disminuir el; disponibilidad de; distress; donde; dosis; dosis de; duración de; durante la; días; días de; el consentimiento; el cual; el de; el diagnóstico; el día; el estudio; el grupo; el inicio; el manejo; el momento; el más; el nivel; el número; el paciente; el pronóstico; el riesgo; el sars; el tiempo; el traslado; el uso; elevación de; embargo; en china; en contra; en cuenta; en el; en este; en la; en los; en salud; en su; en uci; en un; entre el; entre la; entre los; es una; estado de; este; estrategia de; está; evidencia de; evitar la; fin de; final de; fue de; fuera de; fueron; grupo de; hasta el; horas; infección por; inicio de; intensive; la administración; la capacidad; la cual; la decisión; la disponibilidad; la enfermedad; la evidencia; la falla; la hcq; la hipoxemia; la infección; la intubación; la mortalidad; la oxigenación; la pandemia; la presencia; la presión; la relación; la respuesta; la salud; la seguridad; la terapia; la toma; la uci; la utilización; la valoración; la vida; la vía; las; los casos; los cuales; los días; los estudios; los síntomas; luego de; manejo de; mayor; mayoría de; mecánica; medición de; medidas de; mejorar la; mejoría; menor; más de; necesidad de; nivel de; niveles; número de; o por; o se; objetivo de; otros; pacientes con; pacientes covid-19; pacientes críticos; pacientes que; pacientes y; para el; para la; para los; para pacientes; para que; para sars; para su; parte de; patients; pcr; pero; personal de; plasma; por covid-19; por el; por la; por los; por sars; por un; posibilidad de; presión; protocolo de; pueden; pulmonar; punto de; que; que el; que la; que los; que puede; que se; que una; realización de; realizar; recomendación se; recomienda la; recomienda que; reducción de; renal; respiratoria; resultados; retiro de; review; riesgo de; salud y; sars; se debe; se han; se puede; se recomienda; según la; ser; severa; severidad de; shock; si el; si la; si se; sin; sobre el; sobre la; son de; sospecha de; syndrome; síndrome de; tasa de; tener; tener en; teniendo en; tiempo de; tipo de; todos los; tormenta de; trabajadores de; tratamiento de; treatment; uci y; un estudio; un paciente; una; unidad de; uso de; utilizar; ventilation; viral; y al; y cols; y como; y con; y de; y el; y en; y es; y la; y los; y para; y por; y puede; y que; y se; y su; y una cache: cord-315598-qwh72inx.txt plain text: cord-315598-qwh72inx.txt item: #297 of 427 id: cord-315934-h70j2jmt author: Yu, Jianxing title: Respiratory Syncytial Virus Seasonality, Beijing, China, 2007–2015 date: 2019-06-17 words: 3998 flesch: 39 summary: We also observed a yearly cyclic pattern with a distinct periodicity of 4 years for RSV year in the response plot (p<0.001; Figure 5 , panel B). R espiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection in young children worldwide (1-3); 2.7-3.8 million hospitalizations and 94,600-149,400 deaths occur each year among children <5 years of age as a result of RSV infection (4) . keywords: children; infection; rsv; seasonality; study; syncytial; virus; year cache: cord-315934-h70j2jmt.txt plain text: cord-315934-h70j2jmt.txt item: #298 of 427 id: cord-315949-7id5mitl author: Sentilhes, Anne‐Charlotte title: Respiratory virus infections in hospitalized children and adults in Lao PDR date: 2013-06-25 words: 4099 flesch: 42 summary: Epidemiology and etiology of childhood pneumonia Estimates of world-wide distribution of child deaths from acute respiratory infections Lung infection-a public health priority Emerging infectious diseases in southeast Asia: regional challenges to control Development of three multiplex RT-PCR assays for the detection of 12 respiratory RNA viruses Use of a multiplex PCR/RT-PCR approach to assess the viral causes of influenza-like illnesses in Cambodia during three consecutive dry seasons Simultaneous detection of respiratory viruses in children with acute respiratory infection using two different multiplex reverse transcription-PCR assays The role of respiratory viral infections among children hospitalized for community-acquired pneumonia in a developing country Pneumonia research to reduce childhood mortality in the developing world Pocket Book of Hospital Care for Children: Guidelines for the Management of Common Illnesses with Limited Resources Highly pathogenic influenza A(H5N1) virus survival in complex artificial aquatic biotopes The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children Information for Laboratory Diagnosis of Pandemic (H1N1) Pandemic A(H1N1)2009 influenza virus detection by real time RT-PCR: is viral quantification useful? Viral pathogens associated with acute respiratory infections in central Vietnamese children Molecular monitoring of causative viruses in child acute respiratory infection in endemo-epidemic situations in Shanghai Viral etiologies of acute respiratory infections among hospitalized Vietnamese children in Ho Chi Minh City Incidence of respiratory pathogens in persons hospitalized with pneumonia in two provinces in Thailand Viral and atypical bacterial detection in acute respiratory infection in children under five years Rhinovirus and the lower respiratory tract Rhinovirus-associated hospitalizations in young children Rhinovirus associated with severe lower respiratory tract infections in children Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander Viral respiratory infections in hospitalized and community control children in Alaska The burden of hospitalized lower respiratory tract infection due to respiratory syncytial virus in rural Thailand The burden of respiratory syncytial virus infection in young children Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis Two distinct subtypes of human respiratory syncytial virus Genetic variability of group A human respiratory syncytial virus strains circulating in Germany from 1998 to Seroprevalence of anti-RSV IgG in Thai children aged 6 months to 5 years A study of the genetic variability of human respiratory syncytial virus (HRSV) in Cambodia reveals the existence of a new HRSV group B genotype An early report from newly established laboratory-based influenza surveillance in Lao PDR Parainfluenza virus type 3: seasonality and risk of infection and reinfection in young children Specific viruses detected in Nigerian children in association with acute respiratory disease Progress in the development of human parainfluenza virus vaccines Parainfluenza virus type 4 infections in pediatric patients Human parainfluenza virus type 4 infection in Chinese children with lower respiratory tract infections: a comparison study Detection and identification of human parainfluenza viruses 1, 2, 3, and 4 in clinical samples of pediatric patients by multiplex reverse transcription-PCR Contribution of human metapneumovirus to influenza-like infections in North Greece Population-based incidence of human metapneumovirus infection among hospitalized children Human metapneumovirus in infants and young children in Thailand with lower respiratory tract infections; molecular characteristics and clinical presentations Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand Evidence of human coronavirus HKU1 and human bocavirus in Australian children Detection of nine respiratory RNA viruses using three multiplex RT-PCR assays incorporating a novel RNA internal control transcript Detection and typing by molecular techniques of respiratory viruses in children hospitalized for acute respiratory infection in Rome, Italy Single versus dual respiratory virus infections in hospitalized infants Respiratory viral infections detected by multiplex PCR among pediatric patients with lower respiratory tract infections seen at an urban hospital in Delhi from Impact of human metapneumovirus and respiratory syncytial virus co-infection in severe bronchiolitis Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis Respiratory syncytial virus and human rhinoviruses are the major causes of severe lower respiratory tract infections in Kuwait Role of rhinovirus in hospitalized infants with respiratory tract infections in Spain Vientiane climate guide to the average weather & temperatures This study was supported by Surveillance and Investigation of Epidemic Situations in South-East Asia (SISEA) project, a grant from the French Agency for Development (AFD). key: cord-315949-7id5mitl authors: Sentilhes, Anne‐Charlotte; Choumlivong, Khamla; Celhay, Olivier; Sisouk, Thongchanh; Phonekeo, Darouny; Vongphrachanh, Phengta; Brey, Paul; Buchy, Philippe title: Respiratory virus infections in hospitalized children and adults in Lao PDR date: 2013-06-25 journal: keywords: children; infections; influenza; patients; respiratory; study; viruses; years cache: cord-315949-7id5mitl.txt plain text: cord-315949-7id5mitl.txt item: #299 of 427 id: cord-316727-ktrlohm9 author: Razavi, Seyed Mansour title: Treatment and prevention of acute respiratory infections among Iranian hajj pilgrims: a 5-year follow up study and review of the literature date: 2014-05-10 words: 4677 flesch: 46 summary: The main aim of our study was to determine types, frequencies, etiologies, and epidemiologic factors of respiratory diseases among Iranian Hajj pilgrims and to suggest some preventive and treatment strategies. We introduced some epidemiological factors as effective in creating respiratory diseases. keywords: administration; antibiotics; diseases; factors; hajj; infections; influenza; pilgrims; study; treatment cache: cord-316727-ktrlohm9.txt plain text: cord-316727-ktrlohm9.txt item: #300 of 427 id: cord-316956-nnqi0dj1 author: Gamiño‐Arroyo, Ana E. title: Epidemiology and clinical characteristics of respiratory syncytial virus infections among children and adults in Mexico date: 2016-08-18 words: 2502 flesch: 34 summary: CDC protocol of realtime RTPCR for swine influenza A(H1N1) Viral infections in adults hospitalized with community-acquired pneumonia: prevalence, pathogens, and presentation Respiratory syncytial virus-and human metapneumovirus-associated emergency department and hospital burden in adults Respiratory syncytial virus and other respiratory viral infections in older adults with moderate to severe influenza-like illness Respiratory syncytial virus pneumonia among the elderly: an assessment of disease burden Respiratory syncytial virus: how, why and what to do Associations between co-detected respiratory viruses in children with acute respiratory infections Viral coinfection in childhood respiratory tract infections Pre-existing disease is associated with a significantly higher risk of death in severe respiratory syncytial virus infection Epidemiological and clinical data of hospitalizations associated with respiratory syncytial virus infection in children under 5 years of age in Spain: FIVE multicenter study Respiratory syncytial virus genotypes and disease severity among children in hospital Correlation between respiratory syncytial virus genotype and severity of illness Sequencing and analysis of globally obtained human respiratory syncytial virus A and B genomes Epidemiology and clinical characteristics of respiratory syncytial virus infections among children and adults in Mexico ILI-002 study principal investigators, coprincipal investigators, study staff, NIAID, Leidos and Westat staff include the following: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán: Guillermo D. E. Noyola has participated as a member of the speakers' bureau of AbbVie. On the other hand, strengths of our study include the participa- Instituto Nacional de Pediatría: Beatriz Llamosas-Gallardo Hospital Infantil de México Federico Gómez Juana del Carmen Báez National Institute of Allergies and Infectious Disease (NIAID): Cliff Lane, Mary Smolskis, Dean Follmann, Sally Hunsberger La Red is funded by the Mexico Ministry of Health and the U.S. National Institute of Allergy and Infectious Diseases Viral etiology of hospitalized acute lower respiratory infections in children under 5 years of age -a systematic review and meta-analysis Respiratory syncytial virus is an important cause of community-acquired lower respiratory infection among hospitalized adults Rates of hospitalizations for respiratory syncytial virus, human metapneumovirus and influenza virus in older adults Respiratory syncytial virus infection: immune response, immunopathogenesis, and treatment Clinical characteristics and outcomes of influenza and other influenza-like illnesses in Mexico City Performance of different mono-and multiplex nucleic acid amplification tests on a multipathogen external quality assessment panel Viral and host factors in human respiratory syncytial virus pathogenesis Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis Respiratory syncytial virus epidemics: the ups and downs of a seasonal virus Systematic review and meta-analysis of respiratory syncytial virus infection epidemiology in Latin America World Health Organization. keywords: adults; children; infections; patients; rsv; study; virus cache: cord-316956-nnqi0dj1.txt plain text: cord-316956-nnqi0dj1.txt item: #301 of 427 id: cord-317619-o7qfugjw author: Nye, Steven title: Viral Infection in the Development and Progression of Pediatric Acute Respiratory Distress Syndrome date: 2016-11-24 words: 6739 flesch: 26 summary: implications for spread and control Evolution and ecology of influenza A viruses Adaptation of avian influenza A virus polymerase in mammals to overcome the host species barrier The pig as a mixing vessel for influenza viruses: human and veterinary implications Updating the accounts: global mortality of the 1918-1920 Spanish influenza pandemic Swine influenza a outbreak Swine influenza A (H1N1) infection in two children -Southern California Differential susceptibilities of human lung primary cells to H1N1 influenza viruses pandemic influenza A (H1N1): pathology and pathogenesis of 100 fatal cases in the United States Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico Influenza virus pathogenicity regulated by host cellular proteases, cytokines and metabolites, and its therapeutic options Three fatal cases of pandemic 2009 influenza A virus infection in Shenzhen are associated with cytokine storm Antibody and inflammatory response-mediated severity of pandemic 2009 (pH1N1) influenza virus Cytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection Monocyte chemoattractant protein 1 contributes to an adequate immune response in influenza pneumonia Role of inhaled nitric oxide in the management of severe acute respiratory distress syndrome Comparison of two fluid-management strategies in acute lung injury Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome Prone positioning in severe acute respiratory distress syndrome Biological challenges and technological opportunities for respiratory syncytial virus vaccine development Phase-I study MEDI-534, of a live, attenuated intranasal vaccine against respiratory syncytial virus and parainfluenza-3 virus in seropositive children Live-attenuated respiratory syncytial virus vaccines A gene deletion that up-regulates viral gene expression yields an attenuated RSV vaccine with improved antibody responses in children Enhanced neutralizing antibody response induced by respiratory syncytial virus prefusion F protein expressed by a vaccine candidate Antibodies for prevention and treatment of respiratory syncytial virus infections in children Development of a humanized monoclonal antibody (MEDI-493) with potent in vitro and in vivo activity against respiratory syncytial virus Effectiveness of palivizumab in preventing RSV hospitalization in high risk children: a real-world perspective Comparison of intravenous palivizumab and standard of care for treatment of respiratory syncytial virus infection in mechanically ventilated pediatric patients Impact of palivizumab on admission to the ICU for respiratory syncytial virus bronchiolitis: a national survey Safety and antiviral activity of motavizumab, a respiratory syncytial virus (RSV)-specific humanized monoclonal antibody, when administered to RSV-infected children Motavizumab treatment of infants hospitalized with respiratory syncytial virus infection does not decrease viral load or severity of illness Safety and effectiveness of palivizumab in children at high risk of serious disease due to respiratory syncytial virus infection: a systematic review Serum cross-reactive antibody response to a novel influenza A (H1N1) virus after vaccination with seasonal influenza vaccine Safety and immunogenicity following administration of a live, attenuated monovalent 2009 H1N1 influenza vaccine to children and adults in two randomized controlled trials A novel influenza A (H1N1) vaccine in various age groups Pandemic vaccination strategies and influenza severe outcomes during the influenza A(H1N1)pdm09 pandemic and the post-pandemic influenza season: the Nordic experience A controlled trial of aerosolized ribavirin in infants receiving mechanical ventilation for severe respiratory syncytial virus infection Safety issues related to the administration of ribavirin Broad-spectrum antiviral activity of Virazole: 1-beta-d-ribofuranosyl-1,2,4-triazole-3-carboxamide Ribavirin for respiratory syncytial virus infection of the lower respiratory tract in infants and young children Inhaled ribavirin therapy in adult respiratory syncytial virus-induced acute respiratory distress syndrome Virological clearance rate of high-dose oseltamivir or triple-combination antiviral therapy in complicated 2009 pandemic influenza A (H1N1) infection Respiratory syncytial virus Small molecules VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms Oral GS-5806 activity in a respiratory syncytial virus challenge study Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza: randomized controlled trials for prevention and treatment H1N1 influenza and experience in three critical care units Systematic review of influenza resistance to the neuraminidase inhibitors Critically ill children during the 2009-2010 influenza pandemic in the United States Probability of survival after prolonged extracorporeal membrane oxygenation in pediatric patients with acute respiratory failure. While the overall incidence of respiratory virus infection, in particular RSV and influenza A (H1N1) virus, leading to lower respiratory tract disease is widely studied (12, 13), the frequency of progression to pediatric ARDS has yet to be clearly determined. keywords: ards; children; disease; h1n1; infection; influenza; patients; pediatric; rsv; severity; syncytial; treatment; virus cache: cord-317619-o7qfugjw.txt plain text: cord-317619-o7qfugjw.txt item: #302 of 427 id: cord-318229-29cgwivt author: Baier, Claas title: Molecular characteristics and successful management of a respiratory syncytial virus outbreak among pediatric patients with hemato-oncological disease date: 2018-02-13 words: 5700 flesch: 43 summary: We therefore focused on patient to patient transmission early during the outbreak by strict isolation precautions for RSV infected patients and contacts. Looking exclusively at the molecular analysis, it is not possible to disclose the exact transmission pathway of RSV A. RSV A might have been introduced to the ward by an infected patient (index patient) on the ward (maybe case 1) and was then successively transmitted from patient to patient. keywords: case; infection; outbreak; patients; pediatric; rsv; syncytial; transmission; virus; ward cache: cord-318229-29cgwivt.txt plain text: cord-318229-29cgwivt.txt item: #303 of 427 id: cord-318591-ssnlfjap author: Pecego, AC title: Etiology, clinical, and epidemiological characteristics of severe respiratory infection in people living with HIV date: 2020-01-22 words: 4444 flesch: 42 summary: Those with symptom onset greater than 10 days but up to 30 days prior were considered as non-SARI patients ( Figure 1 ). According to SARI classification, we saw that clinical and epidemiological characteristics were evenly distributed with no statistical difference between SARI and non-SARI patients, except for mortality rate, which was significantly more prevalent among non-SARI patients (Table 1) . keywords: days; hiv; infection; influenza; non; patients; plwh; pneumonia; sari; study cache: cord-318591-ssnlfjap.txt plain text: cord-318591-ssnlfjap.txt item: #304 of 427 id: cord-319675-mwy3t1ny author: Gu, Li title: Sustained Viremia and High Viral Load in Respiratory Tract Secretions Are Predictors for Death in Immunocompetent Adults with Adenovirus Pneumonia date: 2016-08-17 words: 3087 flesch: 52 summary: At admission (on day 5–7 after illness onset), the patients in fatal cases presented higher initial viral loads in respiratory tract secretions (8.578 ± 2.115 vs 6.263 ± 1.225 Log(10) copies/ml, p = 0.023). For those with positive AdV PCR testing, serial whole blood and respiratory tract samples were collected until death or discharge. keywords: cases; day; load; patients; samples; tract cache: cord-319675-mwy3t1ny.txt plain text: cord-319675-mwy3t1ny.txt item: #305 of 427 id: cord-319814-tyqb473m author: Zhang, Dingmei title: Epidemiology characteristics of respiratory viruses found in children and adults with respiratory tract infections in southern China date: 2014-06-11 words: 3483 flesch: 44 summary: Implications for design of vaccine trials Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis Epidemiology of respiratory viral infections in two long-term refugee camps in Kenya Etiology and clinical characterization of respiratory virus infections in adult patients attending an emergency department in Beijing Parainfluenza virus infection of young children: estimates of the populationbased burden of hospitalization Characterization of human coronavirus etiology in Chinese adults with acute upper respiratory tract infection by real-time RT-PCR assays Epidemiology of respiratory virus infections among infants and young children admitted to hospital in Oman Novel human bocavirus in children with acute respiratory tract infection Epidemiology of human metapneumovirus Respiratory syncytial virus and parainfluenza virus Mortality attributable to 9 common infections: significant effect of influenza A, respiratory syncytial virus, influenza B, norovirus, and parainfluenza in elderly persons Characterization of a novel coronavirus associated with severe acute respiratory syndrome The 1918 'Spanish' flu: pearls from swine Human respiratory syncytial virus in children with acute respiratory tract infections in China Genetic variability of respiratory syncytial viruses (RSV) prevalent in southwestern China from 2006 to 2009: emergence of subgroup B and A RSV as dominant strains Molecular monitoring of causative viruses in child acute respiratory infection in endemo-epidemic situations in Shanghai Simultaneous detection of influenza A, B, and C viruses, respiratory syncytial virus, and adenoviruses in clinical samples by multiplex reverse transcription nested-PCR assay Simultaneous detection of fourteen respiratory viruses in clinical specimens by two multiplex reverse transcription nested-PCR assays Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia Detection of adenoviruses in stools from healthy persons and patients with diarrhea by two-step polymerase chain reaction Bocavirus infection in hospitalized children WHO estimates of the causes of death in children Seasonal influenza vaccines The absence of enhanced disease with wild type respiratory syncytial virus infection occurring after receipt of live, attenuated, respiratory syncytial virus vaccines Current status of vaccines for parainfluenza virus infections Parainfluenza viruses Parainfluenza virus type 3: seasonality and risk of infection and reinfection in young children Molecular characterization and phylogenetic analysis of human parainfluenza virus type 3 isolated from Saudi Arabia Cloning of a human parvovirus by molecular screening of respiratory tract samples Human bocavirus infection in young children in the United States: molecular epidemiological profile and clinical characteristics of a newly emerging respiratory virus Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand Human bocavirus in Italian patients with respiratory diseases Frequent detection of human rhinoviruses, paramyxoviruses, coronaviruses, and bocavirus during acute respiratory tract infections Human bocavirus infection in children with acute gastroenteritis in Japan and Thailand Human bocavirus 1 and 3 infection in children with acute gastroenteritis in Brazil Respiratory syncytial virus infection in tropical and developing countries Evaluation of viral co-infections in hospitalized and non-hospitalized children with respiratory infections using microarrays Multipathogen infections in hospitalized children with acute respiratory infections Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis Multiple versus single virus respiratory infections: viral load and clinical disease severity in hospitalized children The detection of the specific viral causes of infection provides a useful starting point for an understanding of illness attributable to respiratory infection, and might also provide data relevant to the development of prevention strategies. of risk factors is critical to the successful implementation of a prevention and control program. keywords: children; detection; human; infection; patients; rates; viruses cache: cord-319814-tyqb473m.txt plain text: cord-319814-tyqb473m.txt item: #306 of 427 id: cord-319877-izn315hb author: de Wit, Emmie title: SARS and MERS: recent insights into emerging coronaviruses date: 2016-06-27 words: 9406 flesch: 31 summary: Middle east respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-κB signaling Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: viral mRNAs are resistant to nsp1-induced RNA cleavage A two-pronged strategy to suppress host protein synthesis by SARS coronavirus nsp1 protein Severe acute respiratory syndrome coronavirus nsp1 facilitates efficient propagation in cells through a specific translational shutoff of host mRNA Severe acute respiratory syndrome coronavirus evades antiviral signaling: role of nsp1 and rational design of an attenuated strain Middle East respiratory syndrome coronavirus nsp1 inhibits host gene expression by selectively targeting mRNAs transcribed in the nucleus while sparing mRNAs of cytoplasmic origin Molecular determinants for subcellular localization of the severe acute respiratory syndrome coronavirus open reading frame 3b protein Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists MAVS-mediated apoptosis and its inhibition by viral proteins Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses Mechanisms of action of ribavirin against distinct viruses Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Clinical analysis of the first patient with imported Middle East respiratory syndrome in China Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area Identification of severe acute respiratory syndrome in Canada Development of a standard treatment protocol for severe acute respiratory syndrome A cluster of cases of severe acute respiratory syndrome in Hong Kong Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study Description and clinical treatment of an early outbreak of severe acute respiratory syndrome (SARS) in Guangzhou, PR Severe acute respiratory syndrome (SARS) in Singapore: clinical features of index patient and initial contacts Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays Ribavirin and interferon-β synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques The first application of a potential treatment option for MERS through the repurposing of IFNα2b and ribavirin in a non-human primate model Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study IFN-α2a or IFN-β1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Ribavirin and interferon-α2b as primary and preventive treatment for Middle East respiratory syndrome coronavirus: a preliminary report of two cases Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a non-human primate model of common marmoset Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: a multicentre retrospective matched cohort study Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen Middle East respiratory syndrome-coronavirus infection: a case report of serial computed tomographic findings in a young male patient Combination therapy with lopinavir/ ritonavir, ribavirin and interferon-α for Middle East respiratory syndrome: a case report Clinical implications of five cases of Middle East respiratory syndrome coronavirus infection in South Korea Outbreak From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design Thiopurine analogs and mycophenolic acid synergistically inhibit the papainlike protease of Middle East respiratory syndrome coronavirus Ligand-induced dimerization of Middle East respiratory syndrome (MERS) coronavirus nsp5 protease (3CL pro ): implications for nsp5 regulation and the development of antivirals Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture International Severe Acute Respiratory & Emerging Infection Consortium. 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Coronaviruses post-SARS: update on replication and pathogenesis Coronaviruses: an overview of their replication and pathogenesis SARS-coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulum Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage Infidelity of SARS-CoV nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS Middle East respiratory syndrome coronavirus neutralizing serum antibodies in dromedary camels: a comparative serological study Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Evidence for camel-to-human transmission of MERS coronavirus MERS coronavirus in dromedary camel herd, Saudi Arabia Isolation of MERS coronavirus from a dromedary camel Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study An analysis of the predominant role for nosocomial transmission in the epidemiology of both SARS and MERS Transmission of Middle East respiratory syndrome coronavirus infections in healthcare settings Epidemiology, transmission dynamics and control of SARS: the 2002-2003 epidemic Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study A description of the clinical representation of SARS-CoV respiratory disease in patients from Hong Kong Environmental contamination and viral shedding in MERS patients during MERS-CoV outbreak in South Korea Evidence that infectious MERS-CoV can be detected on common hospital surfaces during an outbreak, which highlights the potential for nosocomial transmission and stresses the need for infection control The role of superspreading in Middle East respiratory syndrome coronavirus (MERS-CoV) transmission Middle East respiratory syndrome coronavirus superspreading event involving 81 persons the role of super-spreaders in infectious disease Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury Angiotensin-converting enzyme 2 protects from severe acute lung failure Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases Biomarkers in acute respiratory distress syndrome The mercurial nature of neutrophils: still an enigma in ARDS? SARS-CoV virus-host interactions and comparative etiologies of acute respiratory distress syndrome as determined by transcriptional and cytokine profiling of formalin-fixed paraffin-embedded tissues Distinct immune response in two MERS-CoV-infected patients: can we go from bench to bedside? Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome Genome wide identification of SARS-CoV susceptibility loci using the Collaborative Cross Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV Rapid generation of a mouse model for Middle East respiratory syndrome A study in which the DPP4-based host restriction is overcome in mice by expression of the human variant of DPP4, leading to the development of several transgenic mouse models MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex keywords: coronavirus; cov; east; host; human; infection; mers; middle; patients; protein; replication; respiratory; ribavirin; sars; syndrome; syndrome coronavirus; transmission; treatment cache: cord-319877-izn315hb.txt plain text: cord-319877-izn315hb.txt item: #307 of 427 id: cord-320107-wels9wt7 author: Gottlieb, Jens title: Community-Acquired Respiratory Viruses date: 2018-03-26 words: 3664 flesch: 36 summary: bilateral lung transplant recipients Chlamydia pneumoniae infection after lung transplantation ALN-RSV01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients Graft loss and CLADonset is hastened by viral pneumonia after lung transplantation Chronic rhinoviral infection in lung transplant recipients Incidence and outcomes of respiratory viral infections in lung transplant recipients: a prospective study Upper and lower respiratory tract viral infections and acute graft rejection in lung transplant recipients Impact of human metapneumovirus and human cytomegalovirus versus other respiratory viruses on the lower respiratory tract infections of lung transplant recipients Resolution of respiratory virus infection requires not only the elimination of the Keywords ► lung transplantation ► community-acquired respiratory viruses ► ribavirin ► bronchiolitis obliterns syndrome The incidence of community-acquired respiratory viruses (CARVs) is $15 cases per 100 patient-years after lung transplantation (LTx). keywords: carv; infection; ltx; lung; patients; recipients; ribavirin; transplant cache: cord-320107-wels9wt7.txt plain text: cord-320107-wels9wt7.txt item: #308 of 427 id: cord-320286-9tumplp3 author: Bastien, Nathalie title: Human Bocavirus Infection, Canada date: 2006-05-17 words: 1429 flesch: 54 summary: Cloning of a human parvovirus by molecular screening of respiratory tract samples Parvoviruses Human parvovirus B19 Respiratory syncytial virus Impact of respiratory virus infections on persons with chronic underlying conditions Human metapneumovirus infection in the Canadian population A 1-year experience with human metapneumovirus in children aged <5 years New human coronavirus, HCoV-NL63, associated with severe lower respiratory tract disease in Australia Human coronavirus NL63 infection in Canada Human coronavirus NL63 infection and other coronavirus infections in children hospitalized with acute respiratory disease in Hong Kong, China Detection of human coronavirus NL63 in young children with bronchiolitis Spectrum of clinical illness in hospitalized patients with common cold virus infections Coronavirus infection in acute lower respiratory tract disease of infants Identification of a new human coronavirus Coronavirus 229E-related pneumonia in immunocompromised patients Nine (50%) HBoV patients were hospitalized; 8 (89%) were <5 years of age, and 1 was between 21 and 50 years of age. keywords: age; hbov; patients; years cache: cord-320286-9tumplp3.txt plain text: cord-320286-9tumplp3.txt item: #309 of 427 id: cord-320950-x02zp349 author: Esposito, Susanna title: Multiplex Platforms for the Identification of Respiratory Pathogens: Are They Useful in Pediatric Clinical Practice? date: 2019-06-04 words: 5864 flesch: 30 summary: F1000Res Antibiotics for community-acquired lower respiratory tract infections secondary to Mycoplasma pneumoniae in children Evaluation of multiple commercial molecular and conventional diagnostic assays for the detection of respiratory viruses in children Testing for respiratory viruses in children: to swab or not to swab Evaluation of Seegene Allplex Respiratory Panel 1 kit for the detection of influenza virus and human respiratory syncytial virus Current best practices for respiratory virus testing Multiplexed detection and identification of respiratory pathogens using the NxTAG R respiratory pathogen panel Respiratory syncytial virus: infection, detection, and new options for prevention and treatment Respiratory syncytial virus infections within families Multiplexed molecular diagnostics for respiratory, gastrointestinal, and central nervous system infections Baloxavir marboxil for uncomplicated influenza in adults and adolescents Enterovirus genotypes among patients with severe acute respiratory illness, influenza-like illness, and asymptomatic individuals in South Africa Prodesse ProFlu+ Assay Multiplex PCR system for the rapid diagnosis of respiratory virus infection: systematic review and meta-analysis Viral shedding and transmission potential of asymptomatic and paucisymptomatic influenza virus infections in the community Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values Persistence of adenovirus nucleic acids in nasopharyngeal secretions: a diagnostic conundrum Treatment of Chlamydial infections: 2014 update Performance evaluation of Allplex Respiratory Panels 1, 2, and 3 for the detection of respiratory viral infection Role of cell culture for virus detection in the age of technology Incubation periods of acute respiratory viral infections: a systematic review Duration of rhinovirus shedding in the upper respiratory tract in the first year of life Verigene Respiratory Pathogens Flex Test Development of a respiratory virus panel test for detection of twenty human respiratory viruses by use of multiplex PCR and a fluid microbead-based assay Respiratory virus detection and clinical diagnosis in children attending day care Influence of age, severity of infection, and co-infection on the duration of respiratory syncytial virus (RSV) shedding Polymerase chain reaction is superior to serology for the diagnosis of acute Mycoplasma pneumoniae infection and reveals a high rate of persistent infection Etiology and impact of coinfections in children hospitalized with community-acquired pneumonia Duration of shedding of respiratory syncytial virus in a community study of Kenyan children Chlamydia persistence: a survival strategy to evade antimicrobial effects in-vitro and in-vivo Etiology and management of pharyngitis and pharyngotonsillitis in children: a current review Rhinoviral infection and asthma: the detection and management of rhinoviruses by airway epithelial cells Human rhinoviruses and severe respiratory infections: is it possible to identify at-risk patients early? Emerging role of Mycoplasma pneumoniae and Chlamydia pneumoniae in paediatric respiratory-tract infections Macrolide-resistant Mycoplasma pneumoniae: its role in respiratory infection Paediatric human metapneumovirus infection: epidemiology, prevention and therapy Bocavirus infection in otherwise healthy children with respiratory disease Prospective evaluation of rhinovirus infection in healthy young children Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis Clinical utility of PCR for common viruses in acute respiratory illness Role of a respiratory viral panel in the clinical management of pediatric inpatients Respiratory viral coinfection and disease severity in children: a systematic review and meta-analysis Carriage of Mycoplasma pneumoniae in the upper respiratory tract of symptomatic and asymptomatic children: an observational study Mycoplasma pneumoniae infections -does treatment help? Impact of Multiplex polymerase chain reaction testing for respiratory pathogens on healthcare resource utilization for pediatric inpatients Clinical evaluation of the Luminex NxTAG Respiratory Pathogen Panel Antibiotic misuse in respiratory tract infections in children and adults-a prospective, multicentre study (TAILORED Treatment) Clinical and epidemiologic characteristics of human bocavirus in Danish infants: results from a prospective birth cohort study Rapid molecular tests for influenza, respiratory syncytial virus, and other respiratory viruses: a systematic review of diagnostic accuracy and clinical impact studies Determining persistence of bocavirus DNA in the respiratory tract of children by pyrosequencing Field evaluation of TaqMan Array Card (TAC) for the simultaneous detection of multiple respiratory viruses in children with acute respiratory infection Clinical impact of RT-PCR for pediatric acute respiratory infections: a controlled clinical trial Mycoplasma pneumoniae in children with acute and refractory asthma New therapies for acute RSV infections: where are we? Comparison of three multiplex PCR assays for detection of respiratory viruses: Anyplex II RV16, AdvanSure RV, and Real-Q RV keywords: children; detection; disease; et al; infection; patients; platforms; respiratory; viruses cache: cord-320950-x02zp349.txt plain text: cord-320950-x02zp349.txt item: #310 of 427 id: cord-321284-0y69n1ea author: El Kholy, A. A. title: The use of multiplex PCR for the diagnosis of viral severe acute respiratory infection in children: a high rate of co-detection during the winter season date: 2016-06-10 words: 3346 flesch: 42 summary: The underrecognized burden of influenza in young children Respiratory syncytial virus and parainfluenza virus Progress in the development of respiratory syncytial virus and parainfluenza virus vaccines Practical implementation of a multiplex PCR for acute respiratory tract infections in children Influenza and other respiratory virus infections in outpatients with medically attended acute respiratory infection during the 2011-12 influenza season Performance of a novel microarray multiplex PCR for the detection of 23 respiratory pathogens (SYMP-ARI study) Does respiratory virus coinfection increases the clinical severity of acute respiratory infection among children infected with respiratory syncytial virus? Human bocavirus and acute wheezing in children Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values A case-control study of acute respiratory tract infection in general practice patients in the Netherlands Respiratory pathogens in children with and without respiratory symptoms Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand Detection of bocavirus in children suffering from acute respiratory tract infections in Saudi Arabia Antiviral strategies against human coronaviruses Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Predominance of rhinovirus in the nose of symptomatic and asymptomatic infants Viruses and bacteria in the etiology of the common cold Rhinovirus illnesses during infancy predict subsequent childhood wheezing Role of respiratory viruses in acute upper and lower respiratory tract illness in the first year of life: a birth cohort study Highly frequent infections with human rhinovirus in healthy young children: a longitudinal cohort study The burden of respiratory syncytial virus infection in young children Influenza A and B virus infections in children Viral etiology of severe pneumonia among Kenyan infants and children Nucleic acids of respiratory viruses causing SARI were detected in 159/177 (89.9 %) patients enrolled in the study. keywords: children; detection; infection; patients; pcr; study; viruses cache: cord-321284-0y69n1ea.txt plain text: cord-321284-0y69n1ea.txt item: #311 of 427 id: cord-321756-a7eh4dkb author: Kwofie, Theophilus B title: Respiratory viruses in children hospitalized for acute lower respiratory tract infection in Ghana date: 2012-04-10 words: 3677 flesch: 42 summary: Rapid and quantitative detection of human adenovirus DNA by real-time PCR Comparison of real-time PCR assays with fluorescent-antibody assays for diagnosis of respiratory virus infections in children Simultaneous detection of influenza viruses A and B using real-time quantitative PCR Respiratory viruses in children hospitalized for acute lower respiratory tract infection in Ghana Review of infectious diseases Viral respiratory infections and their role as public health problem in tropical countries (review) Respiratory syncytial virus infection in tropical and developing countries Update: respiratory syncytial virus activity-United States, 1996-97 season Epidemiology and aetiology of acute bronchiolitis in Hong Kong infants Viral etiology of acute lower respiratory tract infections in hospitalized young children in Northern Taiwan Respiratory adenoviral infections in children: a study of hospitalized cases in southern Taiwan in 2001-2002 Frequent detection of human rhinoviruses, paramyxoviruses, coronaviruses, and bocavirus during acute respiratory tract infections Detection of a broad range of human adenoviruses in respiratory tract samples using a sensitive multiplex real time PCR assay Adenovirus pneumonia in infants and factors for developing bronchiolitis obliterans: a 5-year follow-up Epidemiology and clinical presentation of respiratory syncytial virus infection in a rural area of southern Mozambique Clinical presentation and severity of viral community-acquired pneumonia in young Nepalese children keywords: acute; children; countries; infections; patients; study; tract; viruses cache: cord-321756-a7eh4dkb.txt plain text: cord-321756-a7eh4dkb.txt item: #312 of 427 id: cord-321851-ku4z34lu author: Alosaimi, Bandar title: MERS-CoV infection is associated with downregulation of genes encoding Th1 and Th2 cytokines/chemokines and elevated inflammatory innate immune response in the lower respiratory tract date: 2020-02-29 words: 5630 flesch: 38 summary: CD4 + T-cell immune responses during respiratory viral infections characterized by the production of signature cytokines, IFN-γ, TNF-α, and IL-2 for Th1 cells and IL-4, IL-5, IL-6, IL-9, IL-10, and IL-13 for Th2 cells IL-1β has been associated with tissue damage, neutrophil infiltration, acute inflammatory responses, higher case fatality and severe respiratory viral infection [10, 14, 19, 49, 50] . keywords: chemokines; cov; cytokines; expression; immune; infection; levels; mers; patients; th1; th2; viral cache: cord-321851-ku4z34lu.txt plain text: cord-321851-ku4z34lu.txt item: #313 of 427 id: cord-322524-bq9ok8h1 author: Belongia, Edward A title: Clinical Features, Severity, and Incidence of RSV Illness During 12 Consecutive Seasons in a Community Cohort of Adults ≥60 Years Old date: 2018-11-27 words: 5191 flesch: 39 summary: Additional studies are needed in diverse populations to estimate the burden of adult RSV illness and the potential impact of future licensed vaccines. Samples collected from the 2004-2005 through 2009-2010 seasons were previously tested using the GenMark multiplex assay in a separate study of RSV illness in adults ≥50 years of age [19] . keywords: adults; enrollment; illness; influenza; patients; rsv; study; syncytial; virus; years cache: cord-322524-bq9ok8h1.txt plain text: cord-322524-bq9ok8h1.txt item: #314 of 427 id: cord-322573-1fw1ehzd author: Vicente, Diego title: Human Bocavirus, a Respiratory and Enteric Virus date: 2007-04-17 words: 1297 flesch: 41 summary: To determine the prevalence and clinical characteristics of HBoV, we investigated the presence of this virus in children with respiratory tract infection in our region (Gipúzkoa, Basque Country, Spain). Human bocavirus is associated with respiratory tract infections, particularly in infants and young children. keywords: bocavirus; children; hbov; virus cache: cord-322573-1fw1ehzd.txt plain text: cord-322573-1fw1ehzd.txt item: #315 of 427 id: cord-322657-q4aeood2 author: Jartti, Tuomas title: Respiratory Picornaviruses and Respiratory Syncytial Virus as Causative Agents of Acute Expiratory Wheezing in Children date: 2004-06-17 words: 3171 flesch: 39 summary: Principle and practice Enzyme immunoassays for detection of IgG and IgM antibodies to parainfluenza types 1, 2 and 3 Purification of adenovirus hexon protein by high-performance liquid chromatography Immunoglobulin class-specific antibody response in respiratory syncytial virus infection measured by enzyme immunoassay Enterovirus infection as a risk factor for beta-cell autoimmunity in the prospective birth-cohort trial DIPP Picornaviridae: Rhinoviruses-common cold viruses Detection of enteroviruses and rhinoviruses in clinical specimens by PCR and liquid-phase hybridization Detection of rhinovirus, respiratory syncytial virus, and coronavirus infections in acute otitis media by reverse transcriptase polymerase chain reaction Human metapneumovirus and acute wheezing in children A collaborative study of the aetiology of acute respiratory infections in Britain 1961-4. A report of the Medical Research Council Working Party on acute respiratory virus infections Epidemiologic patterns of acute lower respiratory disease of children in a pediatric group practice Respiratory viral infection in children: a survey in general practice, Roehampton Viral infections in wheezy bronchitis and asthma in children The etiologic and epidemiologic spectrum of bronchitis in pediatric practice Respiratory viral infection and wheezy bronchitis in childhood Role of viruses and bacteria in acute wheezy bronchitis in childhood: a study of sputum Respiratory virus infections and aeroallergens and acute bronchial asthma The association of viruses with acute asthma Risk factors for acute wheezing in infants and children: viruses, passive smoke, and IgE antibodies to inhalant allergens Wheezing bronchitis in children. keywords: children; expiratory; pcr; rsv; study; virus; wheezing cache: cord-322657-q4aeood2.txt plain text: cord-322657-q4aeood2.txt item: #316 of 427 id: cord-323009-frej2qmb author: Nakouné, Emmanuel title: First introduction of pandemic influenza A/H1N1 and detection of respiratory viruses in pediatric patients in Central African Republic date: 2013-02-08 words: 2842 flesch: 40 summary: What are the implications for childhood pneumonia of successfully introducing Hib and pneumococcal vaccines in developing countries Childhood pneumonia-progress and challenges Epidemiological and clinical study of viral respiratory tract infections in children from Italy Occurrence of respiratory virus: time, place and person Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology Influenza in Africa Epidemiological and virological influenza survey in Dakar Pandemic A(H1N1)2009 influenza virus detection by real time RT-PCR: is viral quantification useful? Development of three multiplex RT-PCR assays for the detection of 12 respiratory RNA viruses Use of a multiplex PCR/RT-PCR approach to assess the viral causes of influenza-like illnesses in Cambodia during three consecutive dry seasons epidemiology and factors associated with fatal cases CDC: Introduction and transmission of 2009 pandemic influenza A (H1N1) virus-Kenya pandemic influenza A (H1N1) virus outbreak and response-Rwanda Pandemic H1N1 influenza lessons from the southern hemisphere Transmission characteristics of the 2009 H1N1 influenza pandemic: comparison of 8 Southern hemisphere countries Sentinel surveillance for influenza and other respiratory viruses in Côte d'Ivoire Viral etiology of severe pneumonia among Kenyan infants and children Respiratory viruses in children hospitalized for acute lower respiratory tract infection in Ghana Burden of interpandemic influenza in children younger than 5 years: a 25-year prospective study Population-based surveillance for hospitalizations associated with respiratory syncytial virus, influenza virus, and parainfluenza viruses among young children Incidence and clinical characteristics of the infection by the respiratory syncytial virus in children admitted in Santa Casa de São Paulo Hospital Establishing a surveillance network for severe lower respiratory tract infections in Korean infants and young children Virological and clinical characterization of respiratory infections in children attending an emergency department during the first autumn-winter circulation of pandemic A (H1N1) 2009 influenza virus Molecular monitoring of causative viruses in child acute respiratory infection in endemo-epidemic situations in Shanghai Seasonal variations of 15 respiratory agents illustrated by the application of a multiplex polymerase chain reaction assay Centers for Disease Control and Prevention: key: cord-323009-frej2qmb authors: Nakouné, Emmanuel; Tricou, Vianney; Manirakiza, Alexandre; Komoyo, Francis; Selekon, Benjamin; Gody, Jean Chrysostome; Victoir, Kathleen; Buchy, Philippe; Kazanji, Mirdad title: First introduction of pandemic influenza A/H1N1 and detection of respiratory viruses in pediatric patients in Central African Republic date: 2013-02-08 journal: Virol J DOI: 10.1186/1743-422x-10-49 sha: doc_id: 323009 cord_uid: frej2qmb BACKGROUND: Acute viral respiratory illnesses in children in sub-Saharan Africa have received relatively little attention, although they are much more frequent causes of morbidity and mortality than in developed countries. keywords: car; children; illness; influenza; pandemic; respiratory; study; viruses cache: cord-323009-frej2qmb.txt plain text: cord-323009-frej2qmb.txt item: #317 of 427 id: cord-323066-tvguutak author: Praznik, Ajda title: Risk factors for bronchiolitis severity: A retrospective review of patients admitted to the university hospital from central region of Slovenia date: 2018-08-09 words: 3076 flesch: 34 summary: The role of human coronaviruses in children hospitalized for acute bronchiolitis, acute gastroenteritis, and febrile seizures: a 2-year prospective study Comparing nose-throat swabs and nasopharyngeal aspirates collected from children with symptoms for respiratory virus identification using real-time polymerase chain reaction Comparison of nasal and nasopharyngeal swabs for influenza detection in adults The burden of respiratory syncytial virus infection in young children Incidence and risk factors of hospitalization for bronchiolitis in preterm children: a retrospective longitudinal study in Italy Respiratory syncytial virus infection in Navajo and White Mountain Apache children Comparison of risk factors for human metapneumovirus and respiratory syncytial virus disease severity in young children Risk factors for respiratory syncytial virus bronchiolitis hospital admission in New Zealand Respiratory syncytial virus-associated hospitalizations among children less than 24 months of age Respiratory syncytial virus transplacental antibody transfer and kinetics in mother-infant pairs in Bangladesh Risk factors in children hospitalized with RSV bronchiolitis versus non-RSV bronchiolitis Rates of hospitalization for respiratory syncytial virus infection among children in medicaid Risk factors for respiratory syncytial virus hospitalisation in children with heart disease Variation in inpatient diagnostic testing and management of bronchiolitis Pre-existing disease is associated with a significantly higher risk of death in severe respiratory syncytial virus infection Updated guidance for palivizumab prophylaxis among infants and young children at increased risk of hospitalization for respiratory syncytial virus infection Respiratory syncytial virus and parainfluenza virus Evaluation of risk factors for recurrent wheezing episodes Risk factors for hospital admission with RSV bronchiolitis in England: a population-based birth cohort study Chronic diseases, chromosomal abnormalities, and congenital malformations as risk factors for respiratory syncytial virus hospitalization: a population-based cohort study Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants The relationship of meteorological conditions to the epidemic activity of respiratory syncytial virus Multicenter study of viral etiology and relapse in hospitalized children with bronchiolitis Viral etiologies of infant bronchiolitis, croup and upper respiratory illness during 4 consecutive years Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values Respiratory viral detection in children and adults: comparing asymptomatic controls and patients with community-acquired Pneumonia Bronchiolitis (and RSV) in infants and children Molecular epidemiology of respiratory syncytial virus infections among children with acute respiratory symptoms in a community over three seasons Respiratory syncytial virus disease in preterm infants in the U.S. born at 32-35 weeks gestation not receiving immunoprophylaxis Bronchiolitis management preferences and the influence of pulse oximetry and respiratory rate on the decision to admit Current management of acute bronchiolitis in Switzerland Bronchiolitis management by the Belgian paediatrician: discrepancies between evidence-based medicine and practice Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis Efficacy of bronchodilator therapy in bronchiolitis. The three most frequently detected viruses were respiratory syncytial virus (RSV), human rhinovirus (hRV) and human bocavirus (hBoV) (57.5%, 272/473; 25.6%, 121/473; 18.4%, 87/473). keywords: bronchiolitis; children; group; patients; study; syncytial; virus cache: cord-323066-tvguutak.txt plain text: cord-323066-tvguutak.txt item: #318 of 427 id: cord-323112-e78zpa9c author: WATERER, Grant title: Respiratory infections: A current and future threat date: 2009-07-16 words: 2673 flesch: 29 summary: key: cord-323112-e78zpa9c authors: WATERER, Grant; WUNDERINK, Richard title: Respiratory infections: A current and future threat date: 2009-07-16 journal: Respirology DOI: 10.1111/j.1440-1843.2009.01554.x sha: doc_id: 323112 cord_uid: e78zpa9c Despite all the medical progress in the last 50 years pulmonary infections continue to exact and extremely high human and economic cost. In this final article in the pulmonary infectious diseases series we will discuss why pulmonary infections remain a major health problem and are likely to continue to be so well into the foreseeable future. keywords: community; infections; influenza; new; pathogens; patients; pneumonia cache: cord-323112-e78zpa9c.txt plain text: cord-323112-e78zpa9c.txt item: #319 of 427 id: cord-323551-22v2hn3v author: Galanti, M. title: Rates of asymptomatic respiratory virus infection across age groups date: 2019-04-15 words: 3121 flesch: 36 summary: key: cord-323551-22v2hn3v authors: Galanti, M.; Birger, R.; Ud-Dean, M.; Filip, I.; Morita, H.; Comito, D.; Anthony, S.; Freyer, G. A.; Ibrahim, S.; Lane, B.; Matienzo, N.; Ligon, C.; Rabadan, R.; Shittu, A.; Tagne, E.; Shaman, J. title: Rates of asymptomatic respiratory virus infection across age groups date: 2019-04-15 journal: Epidemiol Infect DOI: 10.1017/s0950268819000505 sha: doc_id: 323551 cord_uid: 22v2hn3v Respiratory viral infections are a leading cause of disease worldwide. These findings indicate a high burden of asymptomatic respiratory virus infection exists in the general population. keywords: age; asymptomatic; children; individuals; infections; symptoms; viruses cache: cord-323551-22v2hn3v.txt plain text: cord-323551-22v2hn3v.txt item: #320 of 427 id: cord-324217-secnz2ta author: Pasdaran, A. title: Volatile oils: Potential agents for the treatment of respiratory infections date: 2016-08-05 words: 7717 flesch: 28 summary: The estimation of essential oil activity both in agar and liquid broth would be simplified through counting the tested microorganisms that can remain in the membrane. Essential oil is one of the most important and wide spread secondary metabolite in plants and this class of phytochemical compounds and their activities needs attention. keywords: activity; antiviral; bacteria; cell; chemical; compounds; effects; gram; infections; inflammation; membrane; microorganisms; oils; plants; potential; tract; treatment cache: cord-324217-secnz2ta.txt plain text: cord-324217-secnz2ta.txt item: #321 of 427 id: cord-324432-k0g3r1lw author: Maykowski, Philip title: Seasonality and clinical impact of human parainfluenza viruses date: 2018-08-29 words: 2345 flesch: 36 summary: The study's objectives were to (a) assess the seasonality of HPIV types 1-4, (b) determine clinical outcomes by HPIV type, and (c) identify risk factors for increased severity of illness. This study aimed to assess seasonality of HPIV types 1‐4, clinical outcomes by HPIV type, and risk factors for illness severity. keywords: community; hpiv; illness; patients; respiratory cache: cord-324432-k0g3r1lw.txt plain text: cord-324432-k0g3r1lw.txt item: #322 of 427 id: cord-324601-s3rgxtg6 author: Mhimbira, F. title: Prevalence and clinical significance of respiratory viruses and bacteria detected in tuberculosis patients compared to household contact controls in Tanzania: a cohort study date: 2019-01-31 words: 3262 flesch: 38 summary: TB patients and controls did not differ in the prevalence of respiratory viruses (Odds Ratio [OR] 1.00, 95%CI 0.71–1.44), but respiratory bacteria were less frequently detected in TB patients (OR 0.70, 95%CI 0.53–0.94). TB patients with respiratory viruses tended to have more frequent lung cavitations (aOR 1.6, 95%CI 0.93–2.7; p 0.089). keywords: controls; household; pathogens; patients; study; tuberculosis; viruses cache: cord-324601-s3rgxtg6.txt plain text: cord-324601-s3rgxtg6.txt item: #323 of 427 id: cord-324775-3x5os79m author: Crowe, J.E. title: Human Respiratory Viruses date: 2008-07-30 words: 5719 flesch: 41 summary: Respiratory virus infections of humans are the most common and frequent infections of man. The anatomy and the cell types of the respiratory tract dictate to a large degree the type of disease observed during respiratory virus infection. keywords: cause; cell; children; disease; human; illness; infection; influenza; rsv; tract; virus; viruses cache: cord-324775-3x5os79m.txt plain text: cord-324775-3x5os79m.txt item: #324 of 427 id: cord-324786-8k81jetq author: Chang, Anne B title: Antibiotics for bronchiectasis exacerbations in children: rationale and study protocol for a randomised placebo-controlled trial date: 2012-08-31 words: 5675 flesch: 38 summary: key: cord-324786-8k81jetq authors: Chang, Anne B; Grimwood, Keith; Robertson, Colin F; Wilson, Andrew C; van Asperen, Peter P; O’Grady, Kerry-Ann F; Sloots, Theo P; Torzillo, Paul J; Bailey, Emily J; McCallum, Gabrielle B; Masters, Ian B; Byrnes, Catherine A; Chatfield, Mark D; Buntain, Helen M; Mackay, Ian M; Morris, Peter S title: Antibiotics for bronchiectasis exacerbations in children: rationale and study protocol for a randomised placebo-controlled trial date: 2012-08-31 journal: Trials DOI: 10.1186/1745-6215-13-156 sha: doc_id: 324786 cord_uid: 8k81jetq BACKGROUND: Despite bronchiectasis being increasingly recognised as an important cause of chronic respiratory morbidity in both indigenous and non-indigenous settings globally, high quality evidence to inform management is scarce. Indeed, no published RCTs addressing the treatment of bronchiectasis exacerbations in children exist. keywords: acid; antibiotic; azithromycin; bronchiectasis; children; clavulanic; cough; data; day; exacerbations; lung; non; placebo; study cache: cord-324786-8k81jetq.txt plain text: cord-324786-8k81jetq.txt item: #325 of 427 id: cord-324843-r43u7sld author: Kockuzu, Esra title: Comprehensive Analysis of Severe Viral Infections of Respiratory Tract admitted to PICUs during the Winter Season in Turkey date: 2019-06-17 words: 3751 flesch: 45 summary: The critically ill child with novel H1N1 influenza A: a case series Continued high incidence of children with severe influenza A(H1N1) pdm09 admitted to paediatric intensive care units in Germany during the first three post-pandemic influenza seasons Paediatric mortality related to pandemic influenza A H1N1 infection in England: an observational populationbased study Human bocavirus and KI/WU polyomaviruses in pediatric intensive care patients Human metapneumovirus infection among children hospitalized with acute respiratory illness Human coronavirus in the 2014 winter season as a cause of lower respiratory tract infection Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology Premorbid factors and outcomes associated with respiratory virus infections in a pediatric intensive care unit Hospital-acquired viral infection increases mortality in children with severe viral respiratory infection An investigation into the prevalence and outcome of patients admitted to a pediatric intensive care unit with viral respiratory tract infections in Cape Town, South Africa The frequency of influenza and bacterial coinfection: a systematic review and meta-analysis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics WHO estimates of the causes of death in children Extrapulmonary manifestations of severe respiratory syncytial virus infection-a systematic review Atypical extrapulmonary presentations of severe respiratory syncytial virus infection requiring intensive care Human bocavirus infection as a cause of severe acute respiratory tract infection in children Critically ill patients with 2009 influenza A(H1N1) infection in Canada Critically ill children with pandemic influenza (H1N1) in pediatric intensive care units in Turkey keywords: age; children; infections; influenza; mortality; patients; viruses cache: cord-324843-r43u7sld.txt plain text: cord-324843-r43u7sld.txt item: #326 of 427 id: cord-324898-bjxpuqhr author: Lazzeri, Marta title: How Italian respiratory physiotherapists have faced and are facing the coronavirus disease 2019 pandemic date: 2020-08-03 words: 1622 flesch: 25 summary: Italian suggestions for pulmonary rehabilitation in COVID-19 patients recovering from acute respiratory failure: results of a Delphi process Middle East respiratory syndrome-coronavirus infection: a case report of serial computed tomographic findings in a young male patient Follow-up chest radiographic findings in patients with MERS-CoV after recovery. Many hospital departments have been converted to admit COVID-19 patients: intensive and respiratory subintensive care beds expaned exponentially; pre-triage to access emergency rooms and separate routes for COVID+ and COVID-patients were established; scheduled activities, both for outpatients and for medical/surgical hospitalization were suspended, except for emergencies. keywords: covid-19; failure; patients; physiotherapists; rehabilitation cache: cord-324898-bjxpuqhr.txt plain text: cord-324898-bjxpuqhr.txt item: #327 of 427 id: cord-324950-ux7shvji author: Saade, Georges title: Coinfections and their molecular consequences in the porcine respiratory tract date: 2020-06-16 words: 11756 flesch: 32 summary: Microorganisms associated with pneumonia in slaughter weight swine Retrospective analysis of etiologic agents associated with respiratory diseases in pigs Infectious agents associated with respiratory diseases in 125 farrow-to-finish pig herds: a cross-sectional study Transcriptome analysis of porcine thymus following porcine cytomegalovirus infection Interaction between Mycoplasma hyopneumoniae and swine influenza virus Epidemiological characteristics of pulmonary pneumocystosis and concurrent infections in pigs in Jeju Island Longitudinal study of respiratory infection patterns of breeding sows in five farrow-to-finish herds Bacterial pathogens associated with lung lesions in slaughter pigs from 125 herds Reorganization and expansion of the nidoviral family Arteriviridae Porcine alveolar macrophage-like cells are pro-inflammatory pulmonary intravascular macrophages that produce large titers of porcine reproductive and respiratory syndrome virus Porcine Reproductive and Respiratory Syndrome Virus (PRRSV): pathogenesis and interaction with the immune system Infection of monocytes with European porcine reproductive and respiratory syndrome virus (PRRSV-1) strain Lena is significantly enhanced by dexamethasone and IL-10 Phenotypic and functional modulation of bone marrow-derived dendritic cells by porcine reproductive and respiratory syndrome virus Porcine reproductive and respiratory syndrome virus productively infects monocyte-derived dendritic cells and compromises their antigen-presenting ability Porcine Reproductive and Respiratory Syndrome Virus Type 1.3 Lena triggers conventional dendritic cells 1 activation and T helper 1 immune response without infecting dendritic cells Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny PRRS virus receptors and their role for pathogenesis Molecular cloning of porcine Siglec-3, Siglec-5 and Siglec-10, and identification of Siglec-10 as an alternative receptor for porcine reproductive and respiratory syndrome virus (PRRSV) Involvement of sialoadhesin in entry of porcine reproductive and respiratory syndrome virus into porcine alveolar macrophages Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus Replacement of porcine CD163 scavenger receptor cysteine-rich domain 5 with a CD163-Like homolog confers resistance of pigs to genotype 1 but not genotype 2 porcine reproductive and respiratory syndrome virus Direct interaction between CD163 N-terminal domain and MYH9 C-terminal domain contributes to porcine reproductive and respiratory syndrome virus internalization by permissive cells Differential production of proinflammatory cytokines in the pig lung during different respiratory virus infections: correlations with pathogenicity Increased production of proinflammatory cytokines following infection with porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae Porcine reproductive and respiratory syndrome virus field isolates differ in in vitro interferon phenotypes Cytokine profiles and phenotype regulation of antigen presenting cells by genotype-I porcine reproductive and respiratory syndrome virus isolates Strain-dependent porcine circovirus type 2 (PCV2) entry and replication in T-lymphoblasts Cell tropism and entry of porcine circovirus 2 Porcine circovirus diseases Characteristics of porcine circovirus-2 replication in lymphoid organs of pigs inoculated in late gestation or postnatally and possible relation to clinical and pathological outcome of infection Porcine circovirus type 2 (PCV2) distribution and replication in tissues and immune cells in early infected pigs Porcine circovirus type 2 displays pluripotency in cell targeting Dendritic cells harbor infectious porcine circovirus type 2 in the absence of apparent cell modulation or replication of the virus Association of lymphopenia with porcine circovirus type 2 induced postweaning multisystemic wasting syndrome (PMWS) Cytokine profiles of peripheral blood mononuclear cells from pigs with postweaning multisystemic wasting syndrome in response to mitogen, superantigen or recall viral antigens Distribution and characterization of IL-10-secreting cells in lymphoid tissues of PCV2-infected pigs Porcine circovirus type 2 (PCV2) viral components immunomodulate recall antigen responses Subset-dependent modulation of dendritic cell activity by circovirus type 2 Review: influenza virus in pigs Influenza The impact of animal age, bacterial coinfection, and isolate pathogenicity on the shedding of porcine reproductive and respiratory syndrome virus in aerosols from experimentally infected pigs Actinobacillus pleuropneumoniae possesses an antiviral activity against porcine reproductive and respiratory syndrome virus Enriched housing reduces disease susceptibility to co-infection with porcine reproductive and respiratory virus (PRRSV) and Actinobacillus pleuropneumoniae (A. pleuropneumoniae) in young pigs Dual infections of PRRSV/influenza or PRRSV/Actinobacillus pleuropneumoniae in the respiratory tract Polybacterial human disease: the ills of social networking How viral and intracellular bacterial pathogens reprogram the metabolism of host cells to allow their intracellular replication Intra-species and inter-species differences in cytokine production by porcine antigen-presenting cells stimulated by Mycoplasma hyopneumoniae Viral interference and interferon Type I interferons in infectious disease Type III interferons in viral infection and antiviral immunity The roles of type I interferon in bacterial infection A role for IFN-alpha beta in virus infection-induced sensitization to endotoxin Influenza trains the host for enhanced susceptibility to secondary bacterial infection Type I interferon induction during influenza virus infection increases susceptibility to secondary Streptococcus pneumoniae infection by negative regulation of γδ T cells Intrinsic interference: non-interferon mediated viral interference Virus-bacteria interactions: implications and potential for the applied and agricultural sciences The antiviral and antitumor effects of defective interfering particles/genomes and their mechanisms RNAi, a new therapeutic strategy against viral infection Non-specific dsRNA-mediated antiviral response in the honey bee Roles of nonstructural polyproteins and cleavage products in regulating Sindbis virus RNA replication and transcription Superinfection prevents recombination of the alphaherpesvirus bovine herpesvirus 1 Classical swine fever virus vs. classical swine fever virus: the superinfection exclusion phenomenon in experimentally infected wild boar Porcine reproductive and respiratory syndrome virus (PRRSV) influences infection dynamics of porcine circovirus type 2 (PCV2) subtypes PCV2a and PCV2b by prolonging PCV2 viremia and shedding Microbiome associations in pigs with the best and worst clinical outcomes following co-infection with porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) keywords: bacteria; cells; coinfections; disease; host; hyopneumoniae; infection; interactions; pathogens; pcv2; pigs; pleuropneumoniae; porcine; prrsv; response; studies; syndrome; type; virus; viruses cache: cord-324950-ux7shvji.txt plain text: cord-324950-ux7shvji.txt item: #328 of 427 id: cord-325353-tx6s4ggu author: Restori, Katherine H. title: Neonatal Immunity, Respiratory Virus Infections, and the Development of Asthma date: 2018-06-04 words: 13734 flesch: 28 summary: Upon discovery of different patterns of T cell response in the mid-1980s [e.g., Th1 vs. Th2 type: reviewed in Ref. Neonatal mouse T cells produce significantly higher levels of IL-4 within 48 h of in vitro T cell receptor (TCR) stimulation (32) compared to adult T cells, which typically take several days to produce high levels of Th2 cytokines (33) . keywords: adult; airway; asthma; cells; development; epithelial; human; immune; infection; life; lung; macrophages; mice; neonatal; production; responses; rsv; th1; th2; type; virus cache: cord-325353-tx6s4ggu.txt plain text: cord-325353-tx6s4ggu.txt item: #329 of 427 id: cord-325611-tu1bn4hu author: Pérez-Sautu, Unai title: Target-independent high-throughput sequencing methods provide evidence that already known human viral pathogens play a main role in respiratory infections with unexplained etiology date: 2019-07-23 words: 5292 flesch: 35 summary: Identification of respiratory viruses by HTS was confirmed by contig-specific RT-PCR analysis. Deaths by cause, age, sex, by country and by region Epidemiology and etiology of childhood pneumonia in 2010: estimates of incidence, severe morbidity, mortality, underlying risk factors and causative pathogens for 192 countries Emerging advances in rapid diagnostics of respiratory infections Mortality due to gastroenteritis of unknown etiology in the United States Deaths due to unknown foodborne agents Viral encephalitis of unknown cause: current perspective and recent advances National Institutes of Health Consensus Development Conference on Infantile Apnea and Home Monitoring Simultaneous detection of influenza A, B, and C viruses, respiratory syncytial virus, and adenoviruses in clinical samples by multiplex reverse transcription nested-PCR assay Simultaneous detection of fourteen respiratory viruses in clinical specimens by two multiplex reverse transcription nested-PCR assays Infections and coinfections by respiratory human bocavirus during eight seasons in hospitalized children A metagenomics study for the identification of respiratory viruses in mixed clinical specimens: an application of the iterative mapping approach Characterization of the nasopharyngeal viral microbiome from children with community-acquired pneumonia but negative for Luminex xTAG keywords: analysis; contigs; control; group; hts; human; infections; pathogens; reads; specimens; virus; viruses cache: cord-325611-tu1bn4hu.txt plain text: cord-325611-tu1bn4hu.txt item: #330 of 427 id: cord-325635-don9qjpz author: Turner, Paul title: Respiratory virus surveillance in hospitalised pneumonia patients on the Thailand-Myanmar border date: 2013-09-16 words: 4306 flesch: 43 summary: key: cord-325635-don9qjpz authors: Turner, Paul; Turner, Claudia; Watthanaworawit, Wanitda; Carrara, Verena; Cicelia, Naw; Deglise, Carole; Phares, Christina; Ortega, Luis; Nosten, Francois title: Respiratory virus surveillance in hospitalised pneumonia patients on the Thailand-Myanmar border date: 2013-09-16 journal: BMC Infect Dis DOI: 10.1186/1471-2334-13-434 sha: doc_id: 325635 cord_uid: don9qjpz BACKGROUND: Pneumonia is a significant cause of morbidity and mortality in the developing world. United Nations High Commissioner for Refugees A community-based study of acute respiratory tract infection in Thai children Influenza pandemic plans: what about displaced populations? Committee for Coordination of Services to Displaced Persons in Thailand (CCSDPT) Influenza in refugees on the Thailand-Myanmar border WHO: Integrated management of childhood illness handbook In Pocket book of hospital care for children: guidelines for the management of common illnesses with limited resources Anonymous: BTS Guidelines for the management of community acquired pneumonia in adults Real-time reverse transcriptase PCR assay for detection of human metapneumoviruses from all known genetic lineages Comparison of nasopharyngeal and oropharyngeal swabs for the diagnosis of eight respiratory viruses by real-time reverse transcription-PCR assays Real-time reverse transcription-polymerase chain reaction assay for SARS-associated coronavirus UNHCR: Health information system Epidemiology of respiratory viral infections in two long-term refugee camps in Kenya RNA viruses in community-acquired childhood pneumonia in semi-urban Nepal; a cross-sectional study The etiology of pneumonia in malnourished and well-nourished Gambian children Respiratory syncytial virus infection in tropical and developing countries Incidence and severity of respiratory syncytial virus pneumonia in rural Kenyan children identified through hospital surveillance Viral etiology of severe pneumonia among Kenyan infants and children Clinical presentation and severity of viral community-acquired pneumonia in young Nepalese children Respiratory syncytial virus infection and disease in infants and young children observed from birth in Kilifi district Respiratory syncytial virus epidemiology in a birth cohort from Kilifi district, Kenya: infection during the first year of life High rates of pneumonia in children under two years of age in a South East Asian refugee population A high burden of respiratory syncytial virus associated pneumonia in children less than two years of age in a South East Asian refugee population The burden of influenza in East and South-East Asia: a review of the English language literature. keywords: children; episodes; influenza; patients; pneumonia; surveillance; virus; viruses; years cache: cord-325635-don9qjpz.txt plain text: cord-325635-don9qjpz.txt item: #331 of 427 id: cord-325783-pqonn0as author: Nicholls, John M title: Lung pathology of fatal severe acute respiratory syndrome date: 2003-05-24 words: 4029 flesch: 44 summary: The histological changes of uncomplicated viral pneumonias are rarely described, and reports tend to be derived from post-mortem examination of patients who succumb to the pneumonia; thus, they may not be representative of the majority of pneumonia patients, who survive. key: cord-325783-pqonn0as authors: Nicholls, John M; Poon, Leo LM; Lee, Kam C; Ng, Wai F; Lai, Sik T; Leung, Chung Y; Chu, Chung M; Hui, Pak K; Mak, Kong L; Lim, Wilna; Yan, Kin W; Chan, Kwok H; Tsang, Ngai C; Guan, Yi; Yuen, Kwok Y; Malik Peiris, JS title: Lung pathology of fatal severe acute respiratory syndrome date: 2003-05-24 journal: Lancet DOI: 10.1016/s0140-6736(03)13413-7 sha: doc_id: 325783 cord_uid: pqonn0as BACKGROUND: Severe acute respiratory syndrome (SARS) is a novel infectious disease with global impact. keywords: coronavirus; disease; influenza; lung; march; patients; pneumonia; sars; syndrome cache: cord-325783-pqonn0as.txt plain text: cord-325783-pqonn0as.txt item: #332 of 427 id: cord-325830-mrtpihc7 author: Nelson, Philipp P. title: Current and Future Point-of-Care Tests for Emerging and New Respiratory Viruses and Future Perspectives date: 2020-04-29 words: 4979 flesch: 29 summary: In the last 20 years, in addition to the emergence of novel influenza and coronaviruses, advances in molecular detection methods have led to the discovery of new respiratory viruses already circulating worldwide (Jartti et al., 2012) . FDA-2014-N-0440 A previously undescribed coronavirus associated with respiratory disease in humans Aetiology: koch's postulates fulfilled for SARS virus Nucleic acid amplification tests for detection of respiratory viruses Identification of a novel polyomavirus from patients with acute respiratory tract infections Assay Manual GMR biosensor arrays: a system perspective Initial performance evaluation of a spotted array mobile analysis platform (MAP) for the detection of influenza A/B, RSV, and MERS coronavirus Appropriate antibiotic use for acute respiratory tract infection in adults: advice for high-value care from the american college of physicians and the centers for disease control and prevention Human metapneumovirus in haematopoietic stem cell transplantation recipients: a case series and review of the diagnostic and therapeutic approach Multiplex PCR system for the rapid diagnosis of respiratory virus infection: systematic review and meta-analysis A rapid and specific assay for the detection of MERS-CoV Disposable autonomous device for swab-to-result diagnosis of influenza Estimates of global seasonal influenzaassociated respiratory mortality: a modelling study New respiratory viral infections Avian influenza a viruses: evolution and zoonotic infection An isothermal, label-free, and rapid one-step RNA amplification/detection assay for diagnosis of respiratory viral infections An electrochemical immunosensor for the corona virus associated with the middle east respiratory syndrome using an array of gold nanoparticle-modified carbon electrodes Recent advances in AIV biosensors composed of nanobio hybrid material A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants Poly-silicon nanowire field-effect transistor for ultrasensitive and labelfree detection of pathogenic avian influenza DNA Cepheid assays Detect a Broad Range of Contemporary Human and Avian Influenza strains Diagnostics for the developing world Development and validation of a one-step real-time PCR assay for simultaneous detection of subtype H5, H7, and H9 avian influenza viruses High prevalence of antibodies against polyomavirus WU, polyomavirus KI, and human bocavirus in German blood donors Respiratory viruses other than influenza virus: impact and therapeutic advances Tackling Drug-Resistant Infections Globally, Final Report and Recommendations Human metapneumovirus: review of an important respiratory pathogen Detection of human bocavirus mRNA in respiratory secretions correlates with high viral load and concurrent diarrhea QIAstat-Dx R Respiratory Panel Instructions for Use: Version 2. keywords: care; coronavirus; detection; diagnosis; et al; human; influenza; pcr; pocts; respiratory; tests; viruses cache: cord-325830-mrtpihc7.txt plain text: cord-325830-mrtpihc7.txt item: #333 of 427 id: cord-326004-wg47sd06 author: Wilson, Patrick T title: Respiratory Pathogens in Children 1 Month to 5 Years of Age Presenting With Undifferentiated Acute Respiratory Distress in 2 District-Level Hospitals in Ghana date: 2018-09-03 words: 2196 flesch: 43 summary: key: cord-326004-wg47sd06 authors: Wilson, Patrick T; Baiden, Frank; Brooks, Joshua C; Giessler, Katie M; Apio, Gavin; Punguyire, Damien; Moresky, Rachel T; Sylverken, Justice; Nyarko-Jectey, Kwadwo; Tagbor, Harry; LaRussa, Philip S title: Respiratory Pathogens in Children 1 Month to 5 Years of Age Presenting With Undifferentiated Acute Respiratory Distress in 2 District-Level Hospitals in Ghana date: 2018-09-03 journal: J Pediatric Infect Dis Soc DOI: 10.1093/jpids/piy090 sha: doc_id: 326004 cord_uid: wg47sd06 Ghanaian children (2176) aged <5 years who presented with undifferentiated acute respiratory distress were tested for respiratory pathogens using a BioFire FilmArray polymerase chain reaction assay. Ghanaian children (2176) aged <5 years who presented with undifferentiated acute respiratory distress were tested for respiratory pathogens using a BioFire FilmArray polymerase chain reaction assay. keywords: children; pathogens; season; specimens; study; virus; years cache: cord-326004-wg47sd06.txt plain text: cord-326004-wg47sd06.txt item: #334 of 427 id: cord-326122-5m1727m1 author: Wishaupt, Jérôme O. title: PCR testing for Paediatric Acute Respiratory Tract Infections date: 2014-08-04 words: 4910 flesch: 36 summary: Diagnosis and management of bronchiolitis Bronchiolitis: recent evidence on diagnosis and management Bronchiolitis management before and after the AAP guidelines Manual of Childhood Infections, The Blue Book Additional diagnostic yield of adding serology to PCR in diagnosing viral acute respiratory infections in Kenyan patients 5 years of age and older Comparison of multiplex PCR assays and conventional techniques for the diagnostic of respiratory virus infections in children admitted to hospital with an acute respiratory illness Currently used nucleic acid amplification tests for the detection of viruses and atypicals in acute respiratory infections Evaluation of respiratory syncytial virus detection by rapid antigen tests in childhood Prospective evaluation of rapid antigen tests for diagnosis of respiratory syncytial virus and human metapneumovirus infections Comparison of BD Directigen EZ RSV and Binax NOW RSV tests for rapid detection of respiratory syncytial virus from nasopharyngeal aspirates in a pediatric population Clinical and financial benefits of rapid detection of respiratory viruses: an outcomes study A randomized, controlled trial of the impact of early and rapid diagnosis of viral infections in children brought to an emergency department with febrile respiratory tract illnesses Cost-effectiveness of rapid diagnosis of viral respiratory tract infections in pediatric patients New molecular virus detection methods and their clinical value in lower respiratory tract infections in children Clinical and economical impact of multiplex respiratory virus assays Impact of rapid detection of viral and atypical bacterial pathogens by real-time polymerase chain reaction for patients with lower respiratory tract infection Does real-time PCR for respiratory virusses change antibiotic use in children admitted at the pediatric intensive care unit with lower respiratory tract infection? Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values Respiratory pathogens in children with and without respiratory symptoms Expanding roles for CD4(+) T cells in immunity to viruses Bordetella pertussis and mixed infections Infection with multiple viruses is not associated with increased disease severity in children with bronchiolitis Multiple versus single virus respiratory infections: viral load and clinical disease severity in hospitalized children Viral respiratory co-infections in pediatric patients admitted for acute respiratory infection and their impact on clinical severity Clinical risk factors are more relevant than respiratory viruses in predicting bronchiolitis severity Multiple simultaneous viral infections in infants with acute respiratory tract infections in Spain Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis Identification of a novel coronavirus in patients with severe acute respiratory syndrome A novel coronavirus associated with severe acute respiratory syndrome SARS virus: the beginning of the unraveling of a new coronavirus Coronavirus as a possible cause of severe acute respiratory syndrome Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus infection control, outbreak management Rapid testing for respiratory syncytial virus in a paediatric emergency department: benefits for infection control and bed management Co-infections in children hospitalised for bronchiolitis: role of roomsharing Empiric antibiotics are justified for infants with respiratory syncytial virus lower respiratory tract infection presenting with respiratory failure: a prospective study and evidence review Viral load drives disease in humans experimentally infected with respiratory syncytial virus Disease severity and viral load are correlated in infants with primary respiratory syncytial virus infection in the community Equal virulence of rhinovirus and respiratory syncytial virus in infants hospitalized for lower respiratory tract infection Respiratory syncytial virus infections in hospitalized infants: association between viral load, virus subgroup, and disease severity Correlation of viral load of respiratory pathogens and co-infections with disease severity in children hospitalized for lower respiratory tract infection Prospective study of human metapneumovirus infection: diagnosis, typing and virus quantification in nasopharyngeal secretions from pediatric patients Quantitation of respiratory viruses in relation to clinical course in children with acute respiratory tract infections Illness severity, viral shedding, and antibody responses in infants hospitalized with bronchiolitis caused by respiratory syncytial virus We thank P. Goswami, MD for critically reviewing the manuscript in the English language. keywords: ari; bronchiolitis; children; disease; infection; pcr; tract; virus; viruses cache: cord-326122-5m1727m1.txt plain text: cord-326122-5m1727m1.txt item: #335 of 427 id: cord-326163-u8nh8cr3 author: van Benten, Inesz J. title: RSV‐induced bronchiolitis but not upper respiratory tract infection is accompanied by an increased nasal IL‐18 response date: 2003-08-18 words: 4394 flesch: 42 summary: The aim of this study was to investigate potential differences in the local nasal immune response between bronchiolitis and upper respiratory tract infection induced by respiratory syncytial virus (RSV). During both RSV‐induced bronchiolitis and upper respiratory tract infection, cellular inflammation was observed. keywords: bronchiolitis; cells; il-18; infection; rsv; tract cache: cord-326163-u8nh8cr3.txt plain text: cord-326163-u8nh8cr3.txt item: #336 of 427 id: cord-327264-j0efi5vc author: Waterer, Grant title: Respiratory infections in the Asia‐Pacific region date: 2017-05-24 words: 558 flesch: 36 summary: In this series on respiratory infections in Respirology, many of the above-mentioned challenges will be covered including the burden of disease due to respiratory pathogens (both acute and long-term), drug-resistant pathogens and newly emerging pathogens. Other reviews will focus on key areas such as the evidence around what is best practice in caring for patients with respiratory infections and key differences in respiratory pathogens in different areas of particular relevance to the Asia-Pacific region. keywords: infections; pathogens cache: cord-327264-j0efi5vc.txt plain text: cord-327264-j0efi5vc.txt item: #337 of 427 id: cord-327493-v2iatbol author: Kwon, Hyo Jin title: Clinical manifestations of respiratory adenoviral infection among hospitalized children in Korea date: 2013-08-05 words: 2824 flesch: 37 summary: Our study demonstrates that respiratory adenovirus infections are an important cause of hospitalization in young children, and contribute to a significant morbidity. In 2007, adenovirus infections occurred endemically throughout the year. keywords: adenovirus; children; fever; infection; patients; study cache: cord-327493-v2iatbol.txt plain text: cord-327493-v2iatbol.txt item: #338 of 427 id: cord-327685-fymfqvp3 author: Channappanavar, Rudragouda title: Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology date: 2017-05-02 words: 5844 flesch: 29 summary: expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection Exacerbated innate host response to SARS-CoV in aged non-human primates Toll-like receptor 3 signaling via TRIF contributes to a protective innate immune response to severe acute respiratory syndrome coronavirus infection The PDZ-binding motif of severe acute respiratory syndrome coronavirus envelope protein is a determinant of viral pathogenesis Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits Prophylaxis with a Middle East respiratory syndrome coronavirus (MERS-CoV)-specific human monoclonal antibody protects rabbits from MERS-CoV infection Infection with MERS-CoV causes lethal pneumonia in the common marmoset Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/ 2012 isolates does not result in lethal disease Receptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection Rapid generation of a mouse model for Middle East respiratory syndrome Animal models for SARS and MERS coronaviruses Animal models of Middle East respiratory syndrome coronavirus infection Pre-and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection A mouse model for MERS coronavirusinduced acute respiratory distress syndrome Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane Interaction of SARS and MERS coronaviruses with the antiviral interferon response Severe acute respiratory syndrome coronavirus nsp1 suppresses host gene expression, including that of type I interferon, in infected cells Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling Interferon and cytokine responses to SARS-coronavirus infection SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon Severe acute respiratory syndrome coronavirus evades antiviral signaling: role of nsp1 and rational design of an attenuated strain The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-kappaB signaling Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists SARS-CoV nucleocapsid protein antagonizes IFN-beta response by targeting initial step of IFN-beta induction pathway, and its C-terminal region is critical for the antagonism Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3 The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists Initial viral load and the outcomes of SARS Proliferative growth of SARS coronavirus in Vero E6 cells Viral load kinetics of MERS coronavirus infection Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand Macrophage-expressed IFN-beta contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice Adaptive immune cells temper initial innate responses Not so fast: adaptive suppression of innate immunity Transcriptomic analysis reveals a mechanism for a prefibrotic phenotype in STAT1 knockout mice during severe acute respiratory syndrome coronavirus infection Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection Genome wide identification of SARS-CoV susceptibility loci using the collaborative cross Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Acute respiratory distress syndrome in critically ill patients with severe acute respiratory syndrome Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome SARS: systematic review of treatment effects Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Treatment with interferon-alpha2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study The use of corticosteroid as treatment in SARS was associated with adverse outcomes: a retrospective cohort study High-dose pulse versus nonpulse corticosteroid regimens in severe acute respiratory syndrome Corticosteroid treatment of severe acute respiratory syndrome in Hong Kong Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques Coronaviruses-drug discovery and therapeutic options IFNlambda is a potent anti-influenza therapeutic without the inflammatory side effects of IFNalpha treatment IFN-lambda resolves inflammation via suppression of neutrophil infiltration and IL-1beta production Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury The TLR4 antagonist Eritoran protects mice from lethal influenza infection Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus Silencing of CCR2 in myocarditis Therapeutic siRNA silencing in inflammatory monocytes in mice Immunomodulatory therapy for severe influenza The effect of inhibition of PP1 and TNFalpha signaling on pathogenesis of SARS coronavirus Acknowledgements We thank Dr. Anthony Fehr for careful review of this manuscript. key: cord-327685-fymfqvp3 authors: Channappanavar, Rudragouda; Perlman, Stanley title: Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology date: 2017-05-02 journal: keywords: acute; coronavirus; cov; disease; ifn; infection; mers; mice; pathogenic; responses; sars; syndrome cache: cord-327685-fymfqvp3.txt plain text: cord-327685-fymfqvp3.txt item: #339 of 427 id: cord-328086-ji2emajn author: Zhou, Jie‐ying title: Human bocavirus and human metapneumovirus in hospitalized children with lower respiratory tract illness in Changsha, China date: 2018-01-11 words: 2103 flesch: 40 summary: A newly discovered human pneumovirus isolated from young children with respiratory tract disease Human metapneumovirus: insights from a ten-year molecular and epidemiological analysis in Germany Outbreak of Human Metapneumovirus Infection in a Severe Motor-and-Intellectual Disabilities Ward in Japan Viral load and acute otitis media development after human metapneumovirus upper respiratory tract infection Clinical disease and viral load in children infected with respiratory syncytial virus or human metapneumovirus Clinical characteristics and viral load of respiratory syncytial virus and human metapneumovirus in children hospitaled for acute lower respiratory tract infection Detection of human metapneumovirus and respiratory syncytial virus by real-time polymerase chain reaction among hospitalized young children in Iran Incidence, Morbidity, and Costs of Human Metapneumovirus Infection in Hospitalized Children High human bocavirus viral load is associated with disease severity in children under five years of age Human bocavirus: current knowledge and future challenges British Thoracic Society guidelines for the management of community acquired pneumonia in children: update 2011 Etiology, seasonality and clinical characterization of viral respiratory infections among hospitalized children in Beirut, Lebanon Infections and coinfections by respiratory human bocavirus during eight seasons in hospitalized children Abdel Baset RW. HBoV infections peaked in summer (32.2%), and HMPV infections peaked in winter (28.9%). keywords: children; hbov; hmpv; human; patients cache: cord-328086-ji2emajn.txt plain text: cord-328086-ji2emajn.txt item: #340 of 427 id: cord-328501-mbwgi56x author: Pang, Junxiong title: Risk factors for febrile respiratory illness and mono-viral infections in a semi-closed military environment: a case-control study date: 2015-07-25 words: 5769 flesch: 42 summary: All known human rhinoviruses have been reported to be present in military recruits during respiratory infection Incidence, etiology, and impact Recent trends of pneumonia morbidity in US Naval personnel Keep your hands clean Influenza C virus infection in military recruits-symptoms and clinical manifestation Respiratory infections in the military Symptomatic respiratory syncytial virus infection in previously healthy young adults living in a crowded military environment Respiratory syncytial virus: an important cause of acute respiratory illness among young adults undergoing military training Viruses associated with acute respiratory infections in Royal Air Force personnel Patterns of infections with adenovirus types 4, 7 and 21 in military recruits during a 9-year survey The French Military influenza surveillance system (MISS): overview of epidemiological and virological results during four influenza seasons Novel influenza A(H1N1) outbreak among French armed forces in 2009: results of Military Influenza Surveillance System Outbreak of febrile respiratory illness caused by adenovirus at a South Korean military training facility: clinical and radiological characteristics of adenovirus pneumonia High isolation rate of adenovirus serotype 7 from South Korean military recruits with mild acute respiratory disease Acute lower respiratory tract infections in soldiers Building military influenza surveillance capacity in West Africa Outbreak of influenza A and B among military recruits: evidence from viral culture and polymerase chain reaction Outbreak of acute respiratory disease caused by human adenovirus type 7 in a military training camp in Shaanxi Outbreak of febrile respiratory illness associated with adenovirus 11a infection in a Singapore military training cAMP Differing clinical characteristics between influenza strains among young healthy adults in the tropics Respiratory viral pathogens among Singapore military servicemen 2009-2012: epidemiology and clinical characteristics Viral agents responsible for febrile respiratory illnesses among military recruits training in tropical Singapore Effectiveness of pandemic H1N1-2009 vaccination in reducing laboratory confirmed influenza infections among military recruits in tropical Singapore Effectiveness of seasonal influenza vaccinations against laboratory-confirmed influenza-associated infections among Singapore military personnel in 2010-2013. keywords: adenovirus; cases; factors; fri; infection; influenza; military; personnel; risk; singapore; study cache: cord-328501-mbwgi56x.txt plain text: cord-328501-mbwgi56x.txt item: #341 of 427 id: cord-328742-r4ht266w author: Heo, Jung Yeon title: Molecular Epidemiology of Human Adenovirus–Associated Febrile Respiratory Illness in Soldiers, South Korea(1) date: 2018-07-17 words: 3084 flesch: 37 summary: Although the data might be insufficient to reflect the epidemiology of respiratory HAdV infection among military personnel in South Korea, the variation of HAdV type over time and the impact of the emergence of HAdV-55 on clinical severity can be observed. We obtained clinical information of the patients with HAdV respiratory infection during the study period from standardized case report forms. keywords: hadv; hadv-55; infection; korea; patients; soldiers; south cache: cord-328742-r4ht266w.txt plain text: cord-328742-r4ht266w.txt item: #342 of 427 id: cord-328829-yywxmioq author: Boixeda, Ramon title: Microbiological study of patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and the usefulness of analytical and clinical parameters in its identification (VIRAE study) date: 2012-05-25 words: 3828 flesch: 36 summary: This prospective observational study of patients admitted for AE-COPD (VIR-AE) included a 2-year follow-up period and was intended to identify the infectious etiology of COPD exacerbations (whether viral or bacterial), as well as to describe the clinical features and analytical variables used to differentiate the cause of exacerbation. A study of stable and exacerbated outpatients using the protected specimen brush Respiratory viral infections in adults with and without chronic obstructive pulmonary disease Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations Prevalence of viral infection detected by PCR and RT-PCR in patients with acute exacerbation of COPD: a systematic review Diagnosis and management of chronic obstructive pulmonary disease: joint guidelines of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) and the Latin Antibiotics in chronic obstructive pulmonary disease exacerbations. keywords: copd; disease; etiology; exacerbations; patients; sputum; study; techniques cache: cord-328829-yywxmioq.txt plain text: cord-328829-yywxmioq.txt item: #343 of 427 id: cord-329263-o5e2go23 author: Kaplan, Nasser M. title: Molecular epidemiology and disease severity of respiratory syncytial virus in relation to other potential pathogens in children hospitalized with acute respiratory infection in Jordan date: 2007-11-26 words: 4176 flesch: 43 summary: Molecular epidemiology of respiratory syncytial virus: Rapid identification of subgroup A lineages The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children Identification of a tenth mRNA of respiratory syncytial virus and assignment of polypeptides to the 10 viral genes Respiratory syncytial virus Detection of microorganisms in the tracheal aspirates of preterm infants by polymerase chain reaction: Association of adenovirus with bronchopulmonary dysplasia Respiratory syncytial virus genotypes and disease severity among children in hospital Human metapneumovirus infection in young children hospitalized with respiratory tract disease Human metapneumovirus in severe respiratory syncytial virus bronchiolitis Rapid identification of nine microorganisms causing acute respiratory tract infections by single tube multiplex reverse transcription-PCR: Feasibility study Occurrence of groups A and B of respiratory syncytial virus over 15 years: Associated epidemiologic and clinical characteristics in hospitalized and ambulatory children Rhinovirus and the lower respiratory tract Human bocavirus infection among children Human metapneumovirus associated with respiratory tract infections in a 3-year study of nasal swabs from infants in Italy Rapid detection of respiratory viruses by centrifugation enhanced cultures from children with acute lower respiratory tract infections Epidemiological profile and clinical associations of human bocavirus and other human parvoviruses Enhanced detection of respiratory syncytial virus by shell vial in children hospitalized with respiratory illnesses in Northern Jordan Two distinct subtypes of human respiratory syncytial virus Evaluation of the antibody specificities of human convalescent-phase sera against the attachment (G) protein of human respiratory syncytial virus: Influence of strain variation and carbohydrate side chains Association of rhinovirus infection with increased disease severity in acute bronchiolitis Circulation patterns of genetically distinct group A and B strains of human respiratory syncytial virus in a community Circulation patterns of group A and B human respiratory syncytial virus genotypes in 5 communities in North America Standard case management of pneumonia in children in developing countries: The cornerstone of the acute respiratory infection programme Dual infection in infants by human metapneumovirus and human respiratory syncytial virus is associated with severe bronchiolitis Respiratory syncytial virus and metapneumovirus in children over two seasons with a high incidence of respiratory infections in Brazil Bronchiolitis-associated mortality and estimates of respiratory syncytial virus-associated deaths among US children, 1979-1997 Evidence of human coronavirus HKU1 and human bocavirus in Australian children Viral etiology of acute respiratory infections among children in Porto Alegre, RS, Brazil Analysis of respiratory syncytial virus genetic variability with amplified cDNAs Rapid and sensitive method using multiplex real-time PCR for diagnosis of infections by influenza A and influenza B viruses, respiratory syncytial virus, and parainfluenza viruses 1, 2,3 and 4 Molecular epidemiology of human respiratory syncytial virus subgroup A over a six-year period (1999-2004) in Argentina Respiratory viruses seasonality in children under five years of age in Severity of respiratory syncytial virus infection is related to virus strain Human metapneumovirus infections cause similar symptoms and clinical severity as respiratory syncytial virus infections Cloning of a human parvovirus by molecular screening of respiratory tract samples Respiratory syncytial virus and human metapneumovirus in children with acute respiratory infections in Yemen Epidemiology and clinical characteristics of respiratory syncytial virus infections in Jordan Frequent detection of human rhinoviruses, paramyxoviruses, coronaviruses and bocavirus during acute respiratory tract infections Respiratory syncytial virus subgroup A in hospitalized children in Zarqa Natural reinfection with respiratory syncytial virus does not boost virus-specific T-cell immunity WHO estimates of the causes of death in children Molecular epidemiology of respiratory syncytial virus Respiratory syncytial virus heterogeneity during an epidemic: Analysis by limited nucleotide sequencing (SH gene) and restriction mapping (N gene) keywords: acute; children; disease; hrsv; infection; rhinovirus; study; virus cache: cord-329263-o5e2go23.txt plain text: cord-329263-o5e2go23.txt item: #344 of 427 id: cord-329306-p5wmqmvj author: Kim, Kiwook title: Rhinovirus Associated Severe Respiratory Failure in Immunocompetent Adult Patient date: 2014-09-30 words: 1019 flesch: 28 summary: Although polymerase chain reaction (PCR) methods have enhanced the detection of respiratory viral infection, PCR cannot help distinguish between with patchy consolidations in the whole lung field, but pleural effusion was not present (Figure 2 ). Second, chronic alcoholic ingestion could be a major immune modulator for respiratory viral infection, apart from alcoholic liver damage. keywords: adults; infection; pneumonia; rhinovirus cache: cord-329306-p5wmqmvj.txt plain text: cord-329306-p5wmqmvj.txt item: #345 of 427 id: cord-329877-vish6v8e author: Lapinsky, Stephen E. title: ICU management of severe acute respiratory syndrome date: 2003-05-09 words: 2641 flesch: 42 summary: This means timing blood analysis and administration of any therapies to minimize entries and use of video camera equipment or windows to monitor SARS patients without direct staff exposure. SARS patients should never be transported while being supported by bag-valve-mask ventilation, and should preferably be intubated. keywords: disease; patients; risk; sars; staff; syndrome; therapy cache: cord-329877-vish6v8e.txt plain text: cord-329877-vish6v8e.txt item: #346 of 427 id: cord-330079-pdaowkop author: Xu, Lin title: Surveillance and Genome Analysis of Human Bocavirus in Patients with Respiratory Infection in Guangzhou, China date: 2012-09-11 words: 4479 flesch: 44 summary: Many reports of adult HBoV infection enrolled no more than 100 samples [2, 8, 12, 29, 30] . In contrast, HBoV positive adults were mainly diagnosed as acute upper respiratory tract infection (AURI) ( Table 3) . keywords: bocavirus; children; hbov; human; infection; patients; pcr; strains; virus cache: cord-330079-pdaowkop.txt plain text: cord-330079-pdaowkop.txt item: #347 of 427 id: cord-330343-p7a8chn4 author: Kelly-Cirino, Cassandra title: An updated roadmap for MERS-CoV research and product development: focus on diagnostics date: 2019-02-01 words: 5814 flesch: 26 summary: WHO MERS-COV R&D Blueprint Plan of Action R&D Blueprint for action to prevent epidemics Progress on the global response, remaining challenges and the way forward Evidence for camel-tohuman transmission of MERS coronavirus Human-dromedary camel interactions and the risk of acquiring zoonotic middle east respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East Respiratory Syndrome Coronavirus (MERS-CoV) origin and animal reservoir Risk factors for MERS coronavirus infection in dromedary camels in Burkina Faso Cross-sectional surveillance of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels and other mammals in Egypt MERS coronaviruses in dromedary camels Geographic distribution of MERS coronavirus among dromedary camels Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Absence of Middle East Respiratory Syndrome Coronavirus in Camelids Antibodies against MERS coronavirus in dromedary camels Serological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Middle East respiratory syndrome coronavirus quasispecies that include homologues of human isolates revealed through whole-genome analysis and virus cultured from dromedary camels in Saudi Arabia Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Lack of middle East respiratory syndrome coronavirus transmission from infected camels MERS coronavirus in dromedary camel herd, Saudi Arabia Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Dromedary camels in northern Mali have high seropositivity to MERS-CoV Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels Serologic Evidence for MERS-CoV Infection in Dromedary Camels Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation MERS-CoV situation update, Map 1. MERS-CoV livestock field surveys by country Epidemiological investigation of Middle East respiratory syndrome coronavirus in dromedary camel farms linked with human infection in Abu Dhabi Emirate Middle East respiratory syndrome coronavirus antibody reactors among camels in Dubai Identification of diverse viruses in upper respiratory samples in dromedary camels from United Arab Emirates MERS CoV: OIE -World organisation for animal health Occupational exposure to dromedaries and risk for MERS-CoV Infection Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Infection in Camel Workers in Qatar During 2013-2014: A Case-Control Study Middle East Respiratory Syndrome (MERS) | Symptoms & Complications | CDC Middle East respiratory syndrome coronavirus disease in children Middle East respiratory syndrome coronavirus disease is rare in children: An update from Saudi Arabia Transmission of MERScoronavirus in household contacts Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description The Role of Super-Spreaders in Infectious Disease Super-spreading events of MERS-CoV infection MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus WHO | Infection prevention and control (IPC) guidance summary. WHO MERS-COV Lab Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Performance and clinical validation of the RealStar MERS-CoV Kit for detection of Middle East respiratory syndrome coronavirus RNA Real-time reverse transcription-PCR assay panel for Middle East respiratory syndrome coronavirus Development of dual taqman based one-step rrt-pcr assay panel for rapid and accurate diagnostic test of MERS-CoV: a novel human coronavirus, ahead of hajj pilgrimage Development and validation of a rapid immunochromatographic assay for detection of Middle East respiratory syndrome coronavirus antigen in dromedary camels An isothermal, label-free, and rapid one-step RNA amplification/detection assay for diagnosis of respiratory viral infections Comparison of ePlex respiratory pathogen panel with laboratory-developed real-time pcr assays for detection of respiratory pathogens Clinical validation of 3 commercial real-time reverse transcriptase polymerase chain reaction assays for the detection of Middle East respiratory syndrome coronavirus from upper respiratory tract specimens A sensitive and specific antigen detection assay for Middle East respiratory syndrome coronavirus A highly specific rapid antigen detection assay for on-site diagnosis of MERS Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity Lateral flow assays Development of monoclonal antibody and diagnostic test for middle east respiratory syndrome coronavirus using cell-free synthesized nucleocapsid antigen Middle East respiratory syndrome (MERS) coronavirus and dromedaries Identification of Mycoplasma suis antigens and development of a multiplex microbead immunoassay Serosurveillance of viral pathogens circulating in West Africa Two-tube multiplex real-time reverse transcription PCR to detect six human coronaviruses A multiplex liquid-chip assay based on Luminex xMAP technology for simultaneous detection of six common respiratory viruses Surveillance and testing for middle east respiratory syndrome coronavirus Using Healthmap to analyse Middle East Respiratory Syndrome (MERS) data Progress in promoting data sharing in public health emergencies WHO | Influenza surveillance outputs Data sharing: make outbreak research open access The weapon potential of a microbe Biological agents: weapons of warfare and bioterrorism Explanation of the Nagoya Protocol on Access and Benefit Sharing and its implication for microbiology Global scientific research commons under the Nagoya Protocol: keywords: camels; coronavirus; cov; detection; development; east; infection; laboratory; mers; middle; middle east; respiratory; syndrome; tests cache: cord-330343-p7a8chn4.txt plain text: cord-330343-p7a8chn4.txt item: #348 of 427 id: cord-330919-dep3v1pt author: Whyte, Claire S title: Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID‐19 date: 2020-04-23 words: 4261 flesch: 30 summary: A Case Series Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism Tissue plasminogen activator (tPA) inhibits interleukin-1 induced acute lung leak Heuze-Vourc'h N. Designing inhaled protein therapeutics for topical lung delivery: what are the next steps? Effects of nebulized antithrombin and heparin on inflammatory and coagulation alterations in an acute lung injury model in rats Aerosolized anticoagulants ameliorate acute lung injury in sheep after exposure to burn and smoke inhalation Heparin nebulization attenuates acute lung injury in sepsis following smoke inhalation in sheep Nebulized anticoagulants in lung injury in critically ill patients-an updated systematic review of preclinical and clinical studies Streptokinase Versus Unfractionated Heparin Nebulization in Patients With Severe Acute Respiratory Distress Syndrome (ARDS): PAR signalling can enhance inflammation in acute lung injury (ALI) by increasing the expression of pro-inflammatory cytokines, including IL-6 keywords: acute; ards; covid-19; distress; fibrin; injury; lung; patients; plasminogen; syndrome cache: cord-330919-dep3v1pt.txt plain text: cord-330919-dep3v1pt.txt item: #349 of 427 id: cord-331228-wbd0s4fo author: Shehata, Mahmoud M. title: Middle East respiratory syndrome coronavirus: a comprehensive review date: 2016-01-20 words: 7527 flesch: 43 summary: respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus spike protein delivered by modified vaccinia virus Ankara efficiently induces virus-neutralizing antibodies Protective efficacy of recombinant Modified Vaccinia virus Ankara (MVA) delivering Middle East Respiratory Syndrome coronavirus spike glycoprotein Evaluation of candidate vaccine approaches for MERS-CoV Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin Cyclophilins as modulators of viral replication Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Ribavirin and interferon α-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis Testing of Middle East respiratory syndrome coronavirus replication inhibitors for the ability to block viral entry Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus The newly emerged SARS-like coronavirus HCoV-EMC also has an Achilles' heel: current effective inhibitor targeting a 3C-like protease Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody Mahmoud M. Shehata, Mokhtar R. Gomaa, Mohamed A. Ali, and Ghazi Kayali declare that they have no conflict of interest. respiratory syndrome coronavirus The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies Inhibition of proprotein convertases abrogates processing of the middle eastern respiratory syndrome coronavirus spike protein in infected cells but does not reduce viral infectivity Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein Furin at the cutting edge: from protein traffic to embryogenesis and disease MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features Characterization of the coronavirus M protein and nucleocapsid interaction in infected cells SARS-beginning to understand a new virus Wildtype and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus Rapid generation of a mouse model for Middle East respiratory syndrome Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease Pre-and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection Pneumonia from human coronavirus in a macaque model Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus Infection with MERS-CoV causes lethal pneumonia in the common marmoset The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits Novel coronavirus-Saudi Arabia: human isolate. keywords: antibodies; arabia; camels; cases; cell; coronavirus; cov; east; human; infection; mers; middle; middle east; protein; saudi; syndrome; syndrome coronavirus cache: cord-331228-wbd0s4fo.txt plain text: cord-331228-wbd0s4fo.txt item: #350 of 427 id: cord-331288-elnwn7l5 author: Grützmacher, Kim title: Human quarantine: Toward reducing infectious pressure on chimpanzees at the Taï Chimpanzee Project, Côte d'Ivoire date: 2017-01-17 words: 3696 flesch: 37 summary: This study investigates the incidence of respiratory symptoms and human respiratory viruses in humans at a human‐great ape interface, the Taï Chimpanzee Project (TCP) in Côte d'Ivoire, and consequently, the effectiveness of a 5‐day quarantine designed to reduce the risk of potential exposure to human respiratory pathogens. This study investigates the incidence of respiratory symptoms and human respiratory viruses in humans at a human-great ape interface, the Taï Chimpanzee Project (TCP) in Côte d'Ivoire, and consequently, the effectiveness of a 5-day quarantine designed to reduce the risk of potential exposure to human respiratory pathogens. keywords: chimpanzees; human; pathogens; quarantine; risk; symptoms cache: cord-331288-elnwn7l5.txt plain text: cord-331288-elnwn7l5.txt item: #351 of 427 id: cord-331520-o9e4qqn4 author: Kistler, Christine E. title: The Winter Respiratory Viral Season During the COVID-19 Pandemic date: 2020-10-26 words: 2728 flesch: 28 summary: Managing Investigations During an Outbreak CMS-3401-IFC, Updating Requirements for Reporting of SARS-CoV-2 Test Results by (CLIA) Additional Policy and Regulatory Revisions in Response to the COVID-19 Public Health Emergency Thinking fast and slow in pneumonia Computerized clinical decision support systems and antibiotic prescribing: a systematic review and meta-analysis Effectiveness and safety of electronically delivered prescribing feedback and decision support on antibiotic use for respiratory illness in primary care: REDUCE cluster randomised trial Evaluation of viruses associated with acute respiratory infections in long-term care facilities using a novel method: Wisconsin, 2016-2019 COVIDApp as an innovative strategy for the management and follow-up of COVID-19 cases in long-term care facilities in Catalonia: implementation study Prognostic value of lung ultrasonography in older nursing home residents affected by COVID-19 Combining procalcitonin and rapid multiplex respiratory virus testing for antibiotic stewardship in older adult patients with severe acute respiratory infection Efficacy of a test-retest strategy in residents and health care personnel of a nursing home facing a COVID-19 outbreak Bacterial and fungal co-infection in individuals with coronavirus: a rapid review to support COVID-19 antimicrobial prescribing Does adherence to the Loeb minimum criteria reduce antibiotic prescribing rates in nursing homes? Successfully reducing antibiotic prescribing in nursing homes Antibiotic use in the nursing home. Different Types of Flu Vaccines Use of 13-Valent Pneumococcal Conjugate Vaccine and 23-Valent Pneumococcal Polysaccharide Vaccine Among Adults Aged ≥65 Years: Updated Recommendations of the Advisory Committee on Immunization Practices Pneumococcal vaccination guidance for post-acute and long-term care settings: recommendations from AMDA's Infection Advisory Committee Recommendations for mandatory influenza vaccinations for health care personnel from AMDA's Infection Advisory Subcommittee Influenza vaccination coverage among health care personnel -United States, 2017-18 influenza season Changes in influenza vaccination requirements for health care personnel in us hospitals Barriers to timely care of acute infections in nursing homes: a preliminary qualitative study Nursing home-associated pneumonia, part I: diagnosis Defining characteristics and risk indicators for diagnosing nursing home-acquired pneumonia and aspiration pneumonia in nursing home residents, using the electronically-modified Delphi Method Community-acquired pneumonia requiring hospitalization among U.S. adults Predictors of mortality for nursing home-acquired pneumonia: a systematic review Viral respiratory infections in a nursing home: a sixmonth prospective study Unprecedented solutions for extraordinary times: Helping long-term care settings deal with the COVID-19 pandemic Role of body temperature in diagnosing bacterial infection in nursing home residents Temperature in nursing home residents systematically tested for SARS-CoV-2 Clinical practice guideline for the evaluation of fever and infection in older adult residents of long-term care facilities: 2008 update by the Infectious Diseases Society of America Does universal testing for COVID-19 work for everyone? Centers for Disease Control and Prevention. keywords: care; covid-19; nursing; residents; respiratory; term; winter cache: cord-331520-o9e4qqn4.txt plain text: cord-331520-o9e4qqn4.txt item: #352 of 427 id: cord-331973-avjw4kx1 author: Das, Shubhagata title: Laboratory Diagnosis of Respiratory Tract Infections in Children – the State of the Art date: 2018-10-18 words: 5144 flesch: 16 summary: RVP fast multiplex assays for detection of respiratory viruses FilmArray, an automated nested multiplex PCR system for multipathogen detection: development and application to respiratory tract infection Syndromic panel-based testing in clinical microbiology RespiFinder: a new multiparameter test to differentially identify fifteen respiratory viruses Adenoviral infections in children: the impact of rapid diagnosis Impact of a rapid respiratory panel test on patient outcomes Viral detection by electron microscopy: past, present and future Comparison of the Luminex NxTAG respiratory pathogen panel and a multiplex in-house real-time PCR panel for the detection of respiratory viruses in symptomatic patients Serology as an adjunct to polymerase chain reaction assays for surveillance of acute respiratory virus infections Point-counterpoint: large multiplex PCR panels should be first-line tests for detection of respiratory and intestinal pathogens Comparison of the Simplexa TM Flu A/B & RSV kit (nucleic acid extraction-dependent assay) and the Prodesse ProFlu + TM assay for detecting influenza and respiratory syncytial viruses Comparison of direct fluorescence assay and real-time rt-PCR as diagnostics for respiratory syncytial virus in young children Evaluation of the QuickLab RSV test, a new rapid lateral-flow immunoassay for detection of respiratory syncytial virus antigen Clinical evaluation of the Luminex NxTAG respiratory pathogen panel Developing molecular amplification methods for rapid diagnosis of respiratory tract infections caused by bacterial pathogens Evaluation of a commercial direct fluorescent-antibody assay for human metapneumovirus in respiratory specimens Evaluation of three immunoassay kits for rapid detection of influenza virus A and B Low prevalence of Chlamydia pneumoniae in adults with communityacquired pneumonia WHO Recommendations on the use of Rapid Testing for Influenza Diagnosis Koneman's Color Atlas and Textbook of Diagnostic Microbiology Guidelines for the management of adult lower respiratory tract infections Electron microscopy: essentials for viral structure, morphogenesis and rapid diagnosis Serology enhances molecular diagnosis of respiratory virus infections other than influenza in children and adults hospitalized with community-acquired pneumonia Impact of rapid influenza testing at triage on management of febrile infants and young children Influence of time to diagnosis of severe influenza on antibiotic use, length of stay, isolation precautions, and mortality: a retrospective study Multiplex PCR point of care testing versus routine, laboratory-based testing in the treatment of adults with respiratory tract infections: a quasi-randomised study assessing impact on length of stay and antimicrobial use Prospective evaluation of rapid antigen tests for diagnosis of respiratory syncytial virus and human metapneumovirus infections Guidelines for the management of adults with hospitalacquired, ventilator-associated, and healthcare-associated pneumonia Detection of influenza A and B viruses and respiratory syncytial virus using CLIA-waived point-of-care assays: a paradigm shift to molecular tests Multicenter evaluation of the ePlex respiratory pathogen panel for the detection of viral and bacterial respiratory tract pathogens in nasopharyngeal swabs Clinical and financial benefits of rapid detection of respiratory viruses: an outcomes study Comparing luminex NxTAGrespiratory pathogen panel and RespiFinder-22 for multiplex detection of respiratory pathogens Evaluation of 12 commercial tests and the complement fixation test for Mycoplasma pneumoniae-specific immunoglobulin G (IgG) and IgM antibodies, with PCR used as the gold standard Multicenter clinical evaluation of the novel Alere TM I Influenza A&B isothermal nucleic acid amplification test A national study of the impact of rapid influenza testing on clinical care in the emergency department Viral bacterial coinfection of the respiratory tract during early childhood Routine molecular point-of-care testing for respiratory viruses in adults presenting to hospital with acute respiratory illness (ResPOC): a pragmatic, open-label, randomised controlled trial Point-of-care testing for respiratory viruses in adults: the current landscape and future potential Comparison of NxTAG respiratory pathogen panel and anyplex II RV16 tests for multiplex detection of respiratory pathogens in hospitalized children WHO estimates of the causes of death in children A large-scale study of respiratory virus infection over 2 years using the Luminex xTAGRVP assay Contribution of a rapid influenza diagnostic test to manage hospitalized patients with suspected influenza The effect of rapid respiratory viral diagnostic testing on antibiotic use in a children's hospital Multiplex PCR and emerging technologies for the detection of respiratory pathogens Diagnostic accuracy of rapid antigen detection tests for respiratory syncytial virus infection: systematic review and meta-analysis Serodiagnosis of acute respiratory infections in children in Georgia Laboratory surge response to pandemic (H1N1) 2009 outbreak Diagnostic accuracy and cost analysis of the Alere TM I Influenza A&B near-patient test using throat swabs Cell culture, cytopathic effect and immunofluorescence diagnosis of viral infection Evaluation of the Xpert Flu rapid PCR assay in highrisk emergency department patients Specimen collection, transport, and processing: virology, in Manual of Clinical Microbiology, 11th Edn Rapid diagnosis of respiratory syncytial virus infections in immunocompromised adults Novel coronavirus and severe acute respiratory syndrome CLIA Categorizations keywords: assays; detection; diagnosis; et al; infections; influenza; pathogens; respiratory; testing; virus; viruses cache: cord-331973-avjw4kx1.txt plain text: cord-331973-avjw4kx1.txt item: #353 of 427 id: cord-332055-lrpfzsog author: DeVos, Elizabeth title: Approach to Adult Patients with Acute Dyspnea date: 2015-11-27 words: 4420 flesch: 40 summary: Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia Prognostic role of echocardiography among patients with acute pulmonary embolism and a systolic arterial pressure of 90 mm Hg or higher Right ventricular dilatation on bedside echocardiography performed by emergency physicians aids in the diagnosis of pulmonary embolism Critical issues in the evaluation and management of adult patients presenting to the emergency department with suspected pulmonary embolism Usefulness of preemptive anticoagulation in patients with suspected pulmonary embolism: a decision analysis Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and D-dimer Prospective multicenter evaluation of the pulmonary embolism rule-out criteria Prognostic significance of dyspnea in patients referred for cardiac stress testing Management of emergency department patients with primary spontaneous pneumothorax: needle aspiration or tube thoracostomy? Clinical presentation of patients with tension pneumothorax: a systematic review Metabolic acidosis in the critically ill: part 1. Patients with panic disorder often describe symptoms similar to those of patients with true airway obstruction despite their normal pulmonary function. keywords: acute; breath; cardiac; chest; dyspnea; lung; management; patients; pneumonia; respiratory; symptoms cache: cord-332055-lrpfzsog.txt plain text: cord-332055-lrpfzsog.txt item: #354 of 427 id: cord-332361-pdoln3nr author: Khor, Chee-Sieng title: Epidemiology and seasonality of respiratory viral infections in hospitalized children in Kuala Lumpur, Malaysia: a retrospective study of 27 years date: 2012-03-20 words: 3808 flesch: 40 summary: The relationship of meteorological conditions to the epidemic activity of respiratory syncytial virus Correlations between clinical illness, respiratory virus infections and climate factors in a tropical paediatric population Influenza seasonality: underlying causes and modeling theories Respiratory viruses detected in hospitalised paediatric patients with respiratory infections Viral agents of acute respiratory infections in young children in Kuala Lumpur Seasonal variation in respiratory syncytial virus chest infection in the tropics Health Facts Cost of hospitalization for respiratory syncytial virus chest infection and implications for passive immunization strategies in a developing nation High direct healthcare costs of patients hospitalised with pandemic (H1N1) 2009 influenza in Malaysia Clinical features of Malaysian children hospitalized with community-acquired seasonal influenza Prospective comparison of R-mix shell vial system with direct antigen tests and conventional cell culture for respiratory virus detection Surveillance of eight respiratory viruses in clinical samples of pediatric patients in southeast Brazil Population-based surveillance for hospitalizations associated with respiratory syncytial virus, influenza virus, and parainfluenza viruses among young children Human metapneumovirus in children Human metapneumovirus in infants and young children in Thailand with lower respiratory tract infections; molecular characteristics and clinical presentations The incidence of human bocavirus infection among children admitted to hospital in Singapore High prevalence of human rhinovirus C infection in Thai children with acute lower respiratory tract disease Human rhinovirus group C in hospitalized children Viral pathogens associated with acute respiratory infections in central Vietnamese children The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children Respiratory viruses in acute respiratory tract infections in Western India Respiratory syncytial virus infection in tropical and developing countries Epidemic influenza and vitamin D Absolute humidity modulates influenza survival, transmission, and seasonality Viral etiology and epidemiology of acute lower respiratory tract infections in Korean children Seasonal trends of viral respiratory tract infections in the tropics Ingerani: Incidence and clinical features of hospitalization because of respiratory syncytial virus lower respiratory illness among children less than two years of age in a rural Asian setting Are meteorological parameters associated with acute respiratory tract infections? keywords: cases; children; infections; influenza; respiratory; rsv; viruses cache: cord-332361-pdoln3nr.txt plain text: cord-332361-pdoln3nr.txt item: #355 of 427 id: cord-332926-8hdkpkgz author: Meissner, H. Cody title: Bronchiolitis date: 2017-07-18 words: 3934 flesch: 28 summary: Early trials indicated that ribavirin therapy was associated with a modest improvement in clinical scores, oxygenation, and duration of mechanical ventilation for infants with severe bronchiolitis due to RSV Clinical Practice Guideline: the diagnosis, management and prevention of bronchiolitis RSV-associated hospitalization among children less than 24 months Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis Technical report: updated guidance for palivizumab prophylaxis among infants and young children at increased risk of hospitalization for respiratory syncytial virus infection Polymicrobial acute respiratory infections in a hospital based pediatric population Bronchodilators for bronchiolitis Nebulized hypertonic saline for acute bronchiolitis in infants Nebulized hypertonic saline for acute bronchiolitis: a systematic review Rhinovirus wheezing illness and genetic risk of childhood-onset asthma The microbiology of asthma Clinical Practice Guideline: the diagnosis, management and prevention of bronchiolitis The burden of RSV infection in young children RSV-associated hospitalization among children less than 24 months RSV-associated hospitalizations among infants and young children in the United States Bronchiolitis associated hospitalizations among U.S. children, 1980-1996 Trends in bronchiolitis hospitalizations in the United States Community-acquired pneumonia requiring hospitalization among United States children Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis Multicenter study of viral etiology and relapse in hospitalized children with bronchiolitis Epidemiology of multiple respiratory viruses in childcare attendees Polymicrobial acute respiratory infections in a hospital based pediatric population RSV transplacental antibody transfer and kinetics in mother-infant pairs in Bangladesh The role of neutralizing antibody in protection of American Indians against RSV disease Maternal RSV antibody titers: season and children matter Technical report: updated guidance for palivizumab prophylaxis among infants and young children at increased risk of hospitalization for respiratory syncytial virus infection Palivizumab prophylaxis reduces hospitalization due to RSV in young children with hemodynamically significant congenital heart disease Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis RSV circulation in seven countries with global disease detection regional centers RSV-associated mortality in hospitalized infants and young children The relationship of meteorological conditions to the epidemic activity of RSV Bronchiolitis: recent evidence on diagnosis and management Respiratory syncytial virus and parainfluenza virus Environmental and demographic risk factors for RSV lower respiratory tract disease The unresolved issue of risk factors for hospitalization of infants with RSV infection born after 33-35 weeks gestation Review of epidemiology and clinical risk factors for severe RSV infection Progress in understanding and controlling RSV: still crazy after all these years Severe human lower respiratory tract illness caused by RSV and influenza virus is characterized by the absence of pulmonary cytotoxic lymphocyte responses Feigin and Cherry's Textbook of Pediatric Infectious Diseases Apnea in children hospitalized with bronchiolitis Incidence of apnea in infants hospitalized with respiratory syncytial virus bronchiolitis: a systematic review Identifying hospitalized infants who have bronchiolitis and are at high risk for apnea Low incidence of RSV hospitalizations in hemodynamically significant congenital heart disease Palivizumab in congenital heart disease: should international guidelines be revised? However, Bordetella pertussis, Chlamydia trachomatis, and Mycoplasma pneumoniae should be included in the differential diagnosis of a young child with lower respiratory tract infection. keywords: bronchiolitis; children; disease; hospitalization; infants; infection; risk; rsv; virus cache: cord-332926-8hdkpkgz.txt plain text: cord-332926-8hdkpkgz.txt item: #356 of 427 id: cord-333026-9f6ecg30 author: Kompanikova, J. title: Microbiologic Methods in the Diagnostics of Upper Respiratory Tract Pathogens date: 2017-03-03 words: 1784 flesch: 42 summary: Upper respiratory tract infection Principles of appropriate antibiotic use for acute pharyngitis in adults: background Infections of the respiratory system Lippincott's illustrated reviews: microbiology Viruses and bacteria in the etiology of the common cold Upper respiratory tract infection workup Medical microbiology, 5th edn How contagious are common respiratory tract infections? Microbiology: a human perspective Treatment of rhinosinusitis in the outpatient setting Characteristics of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus isolated from the nasopharynx of healthy children attending day-care centres in the Czech Republic Acknowledgments This study was supported by Department of Microbiology and Immunology. Upper respiratory tract infections (URIs) involve the moist surface of the eyes and eyelids, the nasolacrimal ducts, the middle ear, paranasal sinuses, mastoid air cells, and the main respiratory passage of the nose and throat as far as the epiglottis and vocal cords. keywords: filmarray; infections; panel; patient cache: cord-333026-9f6ecg30.txt plain text: cord-333026-9f6ecg30.txt item: #357 of 427 id: cord-333286-lr32e0w4 author: Lehtoranta, Liisa title: Role of Probiotics in Stimulating the Immune System in Viral Respiratory Tract Infections: A Narrative Review date: 2020-10-16 words: 6772 flesch: 29 summary: The influence of the microbiome on respiratory health Probiotics for preventing acute upper respiratory tract infections Probiotics for preventing acute upper respiratory tract infections Respiratory virus infections Emerging respiratory viruses other than influenza SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients Epidemiology of viral respiratory infections Epidemiologic, clinical, and virologic characteristics of human rhinovirus infection among otherwise healthy children and adults: Rhinovirus among adults and children Pathogenesis of rhinovirus infection Nasal microbiota clusters associate with inflammatory response, viral load, and symptom severity in experimental rhinovirus challenge Mechanisms of viral mutation Viral manipulation of the host immune response Transmission routes of respiratory viruses among humans Epithelial cells and airway diseases The host immune response in respiratory virus infection: Balancing virus clearance and immunopathology The morphology of virus particles. We searched PubMed, Google Scholar, and Web of Knowledge for pre-clinical and clinical studies investigating the effect of probiotics on respiratory virus infections, immune response, and the course of upper and lower respiratory tract illness. keywords: cells; effects; host; ifn; infection; inflammatory; influenza; probiotics; response; rtis; studies; virus; viruses cache: cord-333286-lr32e0w4.txt plain text: cord-333286-lr32e0w4.txt item: #358 of 427 id: cord-333355-ykmp4ven author: Kuchar, E. title: Pathophysiology of Clinical Symptoms in Acute Viral Respiratory Tract Infections date: 2015-03-19 words: 6667 flesch: 34 summary: A better understanding of the symptoms’ pathogenesis could improve the quality of care for patients with respiratory tract infections. 1 Introduction The literature reports that each year up to 25 million people in the US visit their doctor because of respiratory tract infections. keywords: cells; cytokines; eccles; et al; human; infections; influenza; nasal; rhinovirus; symptoms; tract; tract infections; virus cache: cord-333355-ykmp4ven.txt plain text: cord-333355-ykmp4ven.txt item: #359 of 427 id: cord-333868-qrnsmhws author: Rothman, Richard E. title: Respiratory Hygiene in the Emergency Department date: 2006-08-23 words: 7439 flesch: 30 summary: 4 Internationally, health care worker infection has proven to account for up to 42% of SARS cases in Canada and approximately 25% of cases in Hong Kong. The purpose of this report is to summarize, from both the peer-reviewed literature and public health sources (eg, from the CDC), information most relevant to ED respiratory infection control. keywords: care; control; emergency; health; hospital; infection; influenza; isolation; patients; public; risk; sars; transmission; workers cache: cord-333868-qrnsmhws.txt plain text: cord-333868-qrnsmhws.txt item: #360 of 427 id: cord-335055-gzuug3p5 author: Kwiyolecha, Elizabeth title: Patterns of viral pathogens causing upper respiratory tract infections among symptomatic children in Mwanza, Tanzania date: 2020-10-28 words: 3312 flesch: 38 summary: A simulated clients approach Comparison of nasopharyngeal and oropharyngeal swabs for the diagnosis of eight respiratory viruses by real-time reverse transcription-PCR assays Evaluation of the Bruker MALDI Biotyper for identification of Gram-positive rods-Development of a diagnostic algorithm for the clinical laboratory Performance Standards for Antimicrobial Susceptibility Testing Validation of a multiplex reverse transcriptase PCR ELISA for the detection of 19 respiratory tract pathogens Evaluation of a multiplex reverse transcriptase PCR ELISA for the detection of nine respiratory tract pathogens Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing Seasonality of viral infections: Mechanisms and unknowns An explanation for the seasonality of acute upper respiratory tract viral infections The seasonality of rhinovirus infections and its implications for clinical recognition Epidemiology and seasonality of respiratory viral infections in hospitalized children in Kuala Lumpur, Malaysia: A retrospective study of 27 years Aetiology of acute respiratory infections in children under five years in Nakuru, Kenya Improved detection of respiratory viruses in pediatric outpatients with acute respiratory illness by real-time PCR using nasopharyngeal flocked swabs Risk factors for acute respiratory tract infections in under-five children in Enugu Southeast Nigeria Respiratory tract infections in the tropics Seasonal variations of respiratory viruses detected from children with respiratory tract infections in Riyadh, Saudi Arabia Epidemiology and seasonality of respiratory tract virus infections in the tropics Predictors of disease complications and treatment outcome among patients with chronic suppurative otitis media attending a tertiary hospital Factors associated with colonization of Streptococcus pneumoniae among under-fives attending clinic in Mwanza City Rhinovirus: more than just a common cold virus Rhinovirus infections in the upper airway An update on the pathophysiology of rhinovirus upper respiratory tract infections Adenoviral infections in children: The impact of rapid diagnosis Epidemiological analysis of respiratory viral etiology for influenza-like illness during 2010 in Zhuhai Incubation periods of acute respiratory viral infections: A systematic review Estimating incubation period distributions with coarse data The authors acknowledge the assistance provided by department of pediatrics Mainz University, the department of Microbiology and Immunology-CUHAS-Bugando, and the department of pediatrics and child health-CUHAS-Bugando. key: cord-335055-gzuug3p5 authors: Kwiyolecha, Elizabeth; Groendahl, Britta; Okamo, Bernard; Kayange, Neema; Manyama, Festo; Kidenya, Benson R.; Mahamba, Dina C.; Msanga, Delfina R.; Gehring, Stephan; Majigo, Mtebe; Mshana, Stephen E.; Mirambo, Mariam M. title: Patterns of viral pathogens causing upper respiratory tract infections among symptomatic children in Mwanza, Tanzania date: 2020-10-28 journal: Sci Rep DOI: 10.1038/s41598-020-74555-2 sha: doc_id: 335055 cord_uid: gzuug3p5 Upper-respiratory tract infections (URTI) are the leading causes of childhood morbidities. keywords: age; children; ear; infections; pathogens; rhinovirus; study; tract; urti; viruses cache: cord-335055-gzuug3p5.txt plain text: cord-335055-gzuug3p5.txt item: #361 of 427 id: cord-335116-c83xyev5 author: Proença-Módena, José Luiz title: Respiratory viruses are continuously detected in children with chronic tonsillitis throughout the year date: 2014-07-21 words: 3641 flesch: 31 summary: The fluctuations of respiratory virus detection were compared to the major climatic variables during a two-year period using adenoids and palatine tonsils from 172 children with adenotonsillar hypertrophy and clinical evidence of obstructive sleep apnoea syndrome or recurrent adenotonsillitis, without symptoms of acute respiratory infection (ARI), by TaqMan real-time PCR. Methods: The fluctuations of respiratory virus detection were compared to the major climatic variables during a two-year period using adenoids and palatine tonsils from 172 children with adenotonsillar hypertrophy and clinical evidence of obstructive sleep apnoea syndrome or recurrent adenotonsillitis, without symptoms of acute respiratory infection (ARI), by TaqMan real-time PCR. keywords: adenotonsillar; children; detection; patients; study; tissues; virus; viruses cache: cord-335116-c83xyev5.txt plain text: cord-335116-c83xyev5.txt item: #362 of 427 id: cord-335505-s013j5ex author: Zhang, Chen title: Viral Etiology and Clinical Profiles of Children with Severe Acute Respiratory Infections in China date: 2013-08-22 words: 3187 flesch: 39 summary: Respiratory Viral Panel Fast in a clinical laboratory setting Comparison of three multiplex PCR assays for the detection of respiratory viral infections: evaluation of xTAG respiratory virus panel fast assay, RespiFinder 19 assay and RespiFinder SMART 22 assay Etiology and Incidence of viral and bacterial acute respiratory illness among older children and adults in rural western Kenya Molecular monitoring of causative viruses in child acute respiratory infection in endemo-epidemic situations in Shanghai Respiratory viruses in hospitalized children with acute lower respiratory tract infections in harbin, China Viral etiology of bronchiolitis among pediatric inpatients in northern Taiwan with emphasis on newly identified respiratory viruses Viral etiology of severe pneumonia among Kenyan infants and children Impact of parainfluenza virus infection in pediatric cancer patients Parainfluenza 3 virus and other common respiratory pathogens in children with human immunodeficiency virus infection Parainfluenza and influenza virus infections in pediatric organ transplant recipients Parainfluenza virus infection in adult lung transplant recipients: an emergent clinical syndrome with implications on allograft function Comparison of results of detection of rhinovirus by PCR and viral culture in human nasal wash specimens from subjects with and without clinical symptoms of respiratory illness Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in children Secondary, Comparison analysis was firstly performed between urban and suburban/rural patients in china; In addition, this is also the first study on association analysis Estimates of mortality in children younger than 5 years for Burkina Faso A molecular epidemiological study of respiratory viruses detected in Japanese children with acute wheezing illness Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology Clinical and epidemiological comparison of human metapneumovirus and respiratory syncytial virus in seoul Epidemiology and seasonality of respiratory viral infections in hospitalized children in Kuala Lumpur, Malaysia: a retrospective study of 27 years The global problem of antibiotic resistance A preliminary study of pneumonia etiology among hospitalized children in Kenya Etiology and epidemiology of viral pneumonia among hospitalized children in rural Mozambique: a malaria endemic area with high prevalence of human immunodeficiency virus The burden of respiratory syncytial virus infection in young children Human metapneumovirus and severity of respiratory syncytial virus disease Detection of human metapneumovirus in infants with acute respiratory tract infection Detection of respiratory viruses by molecular methods Development of a respiratory virus panel test for detection of twenty human respiratory viruses by use of multiplex PCR and a fluid microbead-based assay Comparison of the BD Directigen Flu A+B Kit and the Abbott TestPack RSV with a multiplex RT-PCR ELISA for rapid detection of influenza viruses and respiratory syncytial virus Comparison of the Luminex Respiratory Virus Panel fast assay with in-house real-time PCR for respiratory viral infection diagnosis Evaluation of multiple test methods for the detection of the novel 2009 influenza A (H1N1) during the New York City outbreak Enhanced viral etiological diagnosis of respiratory system infection outbreaks by use of a multitarget nucleic acid amplification assay Performance of a rapid molecular multiplex assay for the detection of influenza and picornaviruses Comparison of the Luminex xTAG keywords: children; etiology; infection; patients; sari; study; virus; viruses cache: cord-335505-s013j5ex.txt plain text: cord-335505-s013j5ex.txt item: #363 of 427 id: cord-335567-ssnvr6nj author: Berry, Michael title: Identification of New Respiratory Viruses in the New Millennium date: 2015-03-06 words: 7487 flesch: 33 summary: Between 7% and 19% of all cases of respiratory infections in children are caused by hMPV, in both hospitalized and outpatients [108, 131, 132] and has been reported to be the second most frequently identified virus in respiratory tract infections [133] . Viral upper respiratory tract infection and otitis media complication in young children The economic burden of non-influenza-related viral respiratory tract infection in the United States The clinical impact of human respiratory virus infections The Global Burden of Disease Center for Population and Development Studies: Massachusetts Serious bacterial infections in febrile infants 1 to 90 days old with and without viral infections Children with multiple viral respiratory infections are older than those with single viruses Systematic review of the treatment of upper respiratory tract infection Viral infections of the lower respiratory tract: Old viruses, new viruses, and the role of diagnosis Coronavirus HKU1 and Other Coronavirus Infections in Hong Kong Human coronavirus and acute respiratory illness in older adults with chronic obstructive pulmonary disease Acute viral infections of upper respiratory tract in elderly people living in the community: Comparative, prospective, population based study of disease burden Respiratory viral infections in immunocompetent and immunocompromised persons Community respiratory virus infections in immunocompromised patients with cancer Epidemiology of respiratory viruses in bronchoalveolar lavage samples in a tertiary hospital Impact of viral infections in children with community-acquired pneumonia: keywords: acute; bocavirus; children; coronavirus; disease; hcov; human; infection; metapneumovirus; patients; sars; syndrome; tract; viruses cache: cord-335567-ssnvr6nj.txt plain text: cord-335567-ssnvr6nj.txt item: #364 of 427 id: cord-336335-spap39b7 author: Silva, Denise R title: Respiratory viral infections and effects of meteorological parameters and air pollution in adults with respiratory symptoms admitted to the emergency room date: 2013-08-26 words: 4177 flesch: 41 summary: The contribution of influenza to combined acute respiratory infections, hospital admissions, and deaths in winter Excess hospital admissions for pneumonia and influenza in persons > or = 65 years associated with influenza epidemics in three English health districts: 1987-95 Community-acquired pneumonia Prospective epidemiologic survey of patients with community-acquired pneumonia requiring hospitalization in Switzerland Frequency of detection of respiratory viruses in the lower respiratory tract of hospitalized adults Incidência de infecc ßão viral do trato respirat orio em asma aguda atendida em sala de emergência Surveillance of respiratory virus infections in adult hospital admissions using rapid methods Are meteorological parameters associated with acute respiratory tract infections? Increased susceptibility to RSV infection by exposure to inhaled diesel engine emissions Ultrafine carbon black particles enhance respiratory syncitial virus-induced airway reactivity, pulmonary inflammation, and chemokine expression Updated world map of the K€ oppen-Geiger climate classification Influenza activity-United States and worldwide, 2007-08 season Influenza pandêmica (H1N1) 2009 13, 14 Because of the large impact respiratory virus infections have on morbidity and even mortality, it is important to understand whether and how meteorological factors and exposure to air pollutants could influence respiratory virus infections. keywords: air; cases; ifi; ili; influenza; patients; pollutants; pollution; sari; study cache: cord-336335-spap39b7.txt plain text: cord-336335-spap39b7.txt item: #365 of 427 id: cord-336420-1a2u9p4t author: Söderman, Martina title: Frequent Respiratory Viral Infections in Children with Febrile Neutropenia - A Prospective Follow-Up Study date: 2016-06-16 words: 4204 flesch: 41 summary: Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america A prospective study on the epidemiology of febrile episodes during chemotherapy-induced neutropenia in children with cancer or after hemopoietic stem cell transplantation Respiratory viruses, a common microbiological finding in neutropenic children with fever Frequency and Clinical Outcome of Respiratory Viral Infections and Mixed Viral-bacterial Infections in Children With Cancer, Fever and Neutropenia Nasopharyngeal Detection of Respiratory Viruses in Febrile Neutropenic Children Health-related quality of life anticipated with different management strategies for paediatric febrile neutropaenia European guidelines for empirical antibacterial therapy for febrile neutropenic patients in the era of growing resistance: summary of the Antibiotic resistance is associated with longer bacteremic episodes and worse outcome in febrile neutropenic children with cancer Invasive fungal infections in paediatric acute myeloid leukaemia The Clinical Feature of Invasive Fungal Infection in Pediatric Patients With Hematologic and Malignant Diseases Community-acquired pneumonia requiring hospitalization among U.S. children Respiratory viral infections in children with leukemia Clinical utility of PCR for common viruses in acute respiratory illness Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values Upper respiratory virus detection without parent-reported illness in children is virus-specific Respiratory pathogens in children with and without respiratory symptoms Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in children Frequent and prolonged shedding of bocavirus in young children attending daycare Development and implementation of a molecular diagnostic platform for daily rapid detection of 15 respiratory viruses Coexistence of two clades of enterovirus D68 in pediatric Swedish patients in the summer and fall of 2014 Screening respiratory samples for detection of human rhinoviruses (HRVs) and enteroviruses: comprehensive VP4-VP2 typing reveals high incidence and genetic diversity of HRV species C New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0 Management of respiratory viral infections in hematopoietic cell transplant recipients and patients with hematologic malignancies Influenza A/H1N1 in pediatric oncology patients Pathogenesis of bloodstream infection in children with blood cancer A prospective study of septicaemia on a paediatric oncology unit: a three-year experience at The Royal Liverpool Children's Hospital, Alder Hey, UK Respiratory virus infection among hematopoietic cell transplant recipients: evidence for asymptomatic parainfluenza virus infection Human rhinovirus species associated with hospitalizations for acute respiratory illness in young US children Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia High prevalence of human rhinovirus C infection in Thai children with acute lower respiratory tract disease Human rhinovirus C infections in pediatric hematology and oncology patients Respiratory syncytial viral infection in children with compromised immune function Epidemiology of multiple respiratory viruses in childcare attendees Duration of rhinovirus shedding in the upper respiratory tract in the first year of life Clinical assessment and improved diagnosis of bocavirus-induced wheezing in children Human bocavirus in children with acute lymphoblastic leukemia Persistence of human bocavirus DNA in immunocompromised children Although respiratory viruses are commonly associated with this condition, the etiologic significance of this finding remains unclear and is therefore the subject of this study. keywords: children; episodes; neutropenia; respiratory; viruses cache: cord-336420-1a2u9p4t.txt plain text: cord-336420-1a2u9p4t.txt item: #366 of 427 id: cord-336562-5qmzne98 author: Auten, Richard title: Pediatric pulmonology year in review 2016: Part 2 date: 2017-04-25 words: 2540 flesch: 25 summary: comparisons and limitations of current definitions of bronchopulmonary dysplasia for the prematurity and respiratory outcomes program Lung function gain in preterm infants with and without bronchopulmonary dysplasia Mid-childhood lung function in a cohort of children with new bronchopulmonary dysplasia Global and national burden of diseases and injuries among children and adolescents between 1990 and 2013: findings from the Global Burden of Disease Viral bronchiolitis in children Predictors of asthma following severe respiratory syncytial virus (RSV) bronchiolitis in early childhood Admission to hospital for bronchiolitis in England: trends over five decades, geographical variation and association with perinatal characteristics and subsequent asthma Bronchiolitis: analysis of 10 consecutive epidemic seasons Acute viral bronchiolitis: physician perspectives on definition and clinically important outcomes Spatial clusters of child lower respiratory illnesses associated with community-level risk factors Value in inpatient pediatrics network quality collaborative for improving hospital compliance with AAP bronchiolitis guideline (BQIP). In another study with practical implications, Heikkila et al 59 Factors influencing delivered mean airway pressure during nasal CPAP with the RAM cannula Diagnostic accuracy of capnography during high-frequency ventilation in neonatal intensive care units The effect of prolonged lateral positioning during routine care on regional lung volume changes in preterm infants Role of electrical impedance tomography in clinical practice in pediatric respiratory medicine FGR in the setting of preterm sterile intra-uterine milieu is associated with a decrease in RDS Association of BNP, NTproBNP, and early postnatal pulmonary hypertension in very preterm infants Bronchopulmonary dysplasia impairs L-type amino acid transporter-1 expression in human and baboon lung Pulmonary ventilation and micro-structural findings in congenital diaphragmatic hernia Neonatal hyperoxia increases airway reactivity and inflammation in adult mice Perinatal nicotine exposure induces myogenic differentiation, but not epithelial-mesenchymal transition in rat offspring lung Perinatal nicotine exposure induces asthma in second generation offspring Respiratory effects of air pollution on children Respiratory function and symptoms in young preterm children in the contemporary era Four-locus gene interaction between IL13, IL4, FCER1B, and ADRB2 for asthma in Chinese Han children DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium metaanalysis Associations of early life exposures and environmental factors with asthma among children in rural and urban areas of Guangdong Vitamin D and pulmonary function in obese asthmatic children Sex differences in the association between neck circumference and asthma Lifetime exposure to ambient pollution and lung function in children Association between trafficrelated air pollution and asthma in preschool children in a national Japanese nested case-control study Postpartum depression, a direct and mediating risk factor for preschool wheeze in girls Prenatal maternal stress and atopic diseases in the child: a systematic review of observational human studies Looking beyond patients: can parents' quality of life predict asthma control in children? keywords: asthma; bronchiolitis; children; function; infants; lung; pulmonary cache: cord-336562-5qmzne98.txt plain text: cord-336562-5qmzne98.txt item: #367 of 427 id: cord-336743-udokbcki author: Lilitsis, Emmanouil title: Inspiratory effort and breathing pattern change in response to varying the assist level: a physiological study date: 2020-06-10 words: 3439 flesch: 37 summary: The main findings of the study are: 1) patients respond to changes in ventilatory assist mainly by changing effort per breath; 2) when respiratory drive and/or effort are normal, a wide range of respiratory rate is observed; 3) although respiratory rate changes towards the same direction as effort, neither the magnitude of change, nor the resulting value of respiratory rate are related to the level of effort, suggesting the limited role of respiratory rate in titrating assist to a target level of effort. Yet, neither the magnitude of respiratory rate change nor the resulting absolute value may reliably predict the level of effort after a change in assist. keywords: assist; effort; patients; rate cache: cord-336743-udokbcki.txt plain text: cord-336743-udokbcki.txt item: #368 of 427 id: cord-337137-0ey40gzw author: Lo, Anthony WI title: How the SARS coronavirus causes disease: host or organism? date: 2005-12-17 words: 5203 flesch: 40 summary: CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus Chemokine upregulation in SARS coronavirus infected human monocyte derived dendritic cells DC-SIGN: escape mechanism for pathogens Molecular epidemiology of SARS -from Amoy Gardens to Taiwan Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China The Genome sequence of the SARSassociated coronavirus Characterization of a novel coronavirus associated with severe acute respiratory syndrome A novel severe acute respiratory syndrome coronavirus protein, U274, is transported to the cell surface and undergoes endocytosis Characterization of a unique group-specific protein (U122) of the severe acute respiratory syndrome coronavirus Specific epitopes of the structural and hypothetical proteins elicit variable humoral responses in SARS patients The 3a protein of severe acute respiratory syndromeassociated coronavirus induces apoptosis in Vero E6 cells The severe acute respiratory syndrome coronavirus 3a is a novel structural protein Severe acute respiratory syndrome coronavirus 3a protein is a viral structural protein Identification of a novel protein 3a from severe acute respiratory syndrome coronavirus The severe acute respiratory syndrome coronavirus 3a protein up-regulates expression of fibrinogen in lung epithelial cells Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway The pulmonary physician in critical care * Here, we review the pathology of SARS infection. keywords: acute; cells; coronavirus; cov; disease; infection; lung; patients; proteins; sars; syndrome cache: cord-337137-0ey40gzw.txt plain text: cord-337137-0ey40gzw.txt item: #369 of 427 id: cord-337562-pkejb0a9 author: Bialasiewicz, Seweryn title: Merkel Cell Polyomavirus DNA in Respiratory Specimens from Children and Adults date: 2009-03-17 words: 1743 flesch: 43 summary: I n the past 2 years, several previously unknown human polyomaviruses (PyVs) have been identifi ed: KI virus (KIPyV) (1) and WU virus (WUPyV) (2) from respiratory samples, and more recently, Merkel cell polyomavirus (MCPyV), most commonly from Merkel cell carcinoma tissue (3) . In this study, MCPyV was detected in 1.3% of respiratory samples collected from symptomatic persons. keywords: cell; mcpyv; merkel; patients; samples; tract cache: cord-337562-pkejb0a9.txt plain text: cord-337562-pkejb0a9.txt item: #370 of 427 id: cord-337747-7sb03moe author: Lagare, Adamou title: Molecular detection of respiratory pathogens among children aged younger than 5 years hospitalized with febrile acute respiratory infections: A prospective hospital‐based observational study in Niamey, Niger date: 2019-10-11 words: 2652 flesch: 32 summary: Influenza sentinel surveillance among patients with influenza-like-illness and severe acute respiratory illness within the framework of the National Reference Laboratory Detection of respiratory viruses by real-time polymerase chain reaction in outpatients with acute respiratory infection Sentinel surveillance for influenza and other respiratory viruses in Cote d'Ivoire Viral etiology of severe acute respiratory infections in hospitalized children in Cameroon Respiratory viral coinfections identified by a 10-plex real-time reverse-transcription polymerase chain reaction assay in patients hospitalized with severe acute respiratory illness-South Africa Human bocavirus, coronavirus, and polyomavirus detected among patients hospitalised with severe acute respiratory illness in South Africa Viral etiologies of lower respiratory tract infections among Egyptian children under five years of age Viral etiology of respiratory infections in children under 5 years old living in tropical rural areas of Senegal: the EVIRA project Clinical and epidemiological characteristics of acute respiratory virus infections in Vietnamese children Epidemiology of acute respiratory infections in children in Guangzhou: a three-year study Bacterial and viral pathogen spectra of acute respiratory infections in under-5 children in hospital settings in Dhaka city Viral and atypical bacterial detection in acute respiratory infection in children under five years Viral and atypical bacterial etiology of acute respiratory infections in children under 5 years old living in a rural tropical area of Madagascar Viral etiologies of acute respiratory infections among hospitalized Vietnamese children in Ho Chi Minh City Seasonal trends of viral respiratory tract infections in the tropics Investigation of respiratory syncytial virus-associated deaths among US children aged <2 years Clinical and molecular epidemiology of human parainfluenza viruses 1-4 in children from Viet Nam Viral etiology of respiratory tract infections in children at the pediatric hospital in Ouagadougou (Burkina Faso) Spatiotemporal circulation of influenza viruses in 5 African countries during 2008-2009: a collaborative study of the Institut Pasteur International Network Influenza transmission during a oneyear period (2009-2010) in a Sahelian city: low temperature plays a major role The role of multiplex PCR test in identification of bacterial pathogens in lower respiratory tract infections Clinico-pathological study of atypical pathogens in community-acquired pneumonia: a prospective study Serotype distribution and antimicrobial sensitivity profile of Streptococcus pneumoniae carried in healthy toddlers before PCV13 introduction in Niamey Response to conjugate Haemophilus influenzae B vaccine among infants in Niamey, Niger Etiology and factors associated with pneumonia in children under 5 years of age in Mali: a prospective case-control study Performance of surveillance case definitions in detecting respiratory syncytial virus infection among young children hospitalized with severe respiratory illness-South Africa Molecular detection of respiratory pathogens among children aged younger than 5 years hospitalized with febrile acute respiratory infections: A prospective hospital-based observational study in Niamey We are thankful to the MoH, CERMES, and clinicians and nurses at the HNN and HNL for their contributions. In Niger, acute respiratory infections (ARIs) are the second most common cause of death in children aged younger than 5 years. keywords: acute; ari; children; infections; respiratory; study; years cache: cord-337747-7sb03moe.txt plain text: cord-337747-7sb03moe.txt item: #371 of 427 id: cord-339009-wcoch07b author: File, Thomas M. title: Severe Acute Respiratory Syndrome: Pertinent Clinical Characteristics and Therapy date: 2012-08-23 words: 6029 flesch: 43 summary: The majority of cases have been reported among healthcare providers and family members of SARS patients. All staff entering these infected and 13 infected healthcare providers who had documentrestricted areas follow strict and stepwise 'gowning' and 'degowned contacts with SARS patients (table V) . keywords: acute; cases; coronavirus; cov; days; disease; illness; onset; patients; sars; syndrome; transmission cache: cord-339009-wcoch07b.txt plain text: cord-339009-wcoch07b.txt item: #372 of 427 id: cord-339039-6gyo9rya author: Bonvehí, Pablo E. title: Transmission and Control of Respiratory Viral Infections in the Healthcare Setting date: 2018-04-30 words: 4740 flesch: 34 summary: They point out the main characteristics of these viruses in immunosuppressed hosts such as prolonged excertion and higher morbidity and mortality in relation to normal hosts The influenza viruses and influenza Incidence and recall of influenza in a cohort of Glasgow healthcare workers during the 1993-4 epidemic: results of serum testing and questionnaire Adenovirus in solid organ transplant recipients Prolonged recovery of desiccated adenoviral serotypes 5, 8, and 19 from plastic and metal surfaces in vitro Potential role of hands in the spread of respiratory viral infections: studies with human parainfluenza virus 3 and rhinovirus 14 Infection Control of Nosocomial Respiratory Viral Disease in the Immunocompetent Host An outbreak of human parainfluenza virus 3 infection in an outpatient hematopoietic stem cell transplantation clinic Dare and Talbot make a very good description of health care acquired viral respiratory infections, their different control measures(education, hand-washing, isolation, PPE, cohorting of patients and personnel) and other measures such as influenza vaccination Parainfluenza virus infections in hematopoietic cell transplant recipients and hematologic malignancy patients: a systematic review Respiratory virus infection among hematopoietic cell transplant recipients: evidence for asymptomatic parainfluenza virus infection Viral respiratory tract infections in transplant patients: epidemiology, recognition and management How contagious are common respiratory tract infections? Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission An outbreak of respiratory syncytial virus in a bone marrow transplant center Detection and control of a nosocomial respiratory syncytial virus outbreak in a stem cell transplantation unit: the role of palivizumab Respiratory syncytial virus infection in adults Immunization of health-care personnel: recommendations of the Advisory Committee on Immunization Practices (ACIP) Influenza Vaccination of Healthcare Workers: Critical Analysis of the Evidence for Patient Benefit Underpinning Policies of Enforcement Safety and effectiveness of neuraminidase inhibitors for influenza treatment, prophylaxis, and outbreak control: a systematic review of systematic reviews and/or meta-analyses Oseltamivir and inhaled zanamivir as influenza prophylaxis in Thai heaith workers: a randomized, double-blind, placebo-controlled safety trial over 16 weeks Adenovirus type 8 epidemic keratoconjunctivitis in an eye clinic: risk factors and control Adenovirus: current epidemiology and emerging approaches to prevention and treatment Emerging viral respiratory tract infections-environmental risk factors and transmission Safety and immunogenicity of an intranasal Sendai virus-based human parainfluenza virus type 1 vaccine in 3-to 6-year-old children An opportunistic pathogen afforded ample opportunities: Middle East Respiratory Syndrome Coronavirus Viral respiratory infections have been recognized as a cause of severe illness in immunocompromised and non-immunocompromised hosts. keywords: contact; control; healthcare; infections; influenza; measures; patients; rsv; transmission; virus cache: cord-339039-6gyo9rya.txt plain text: cord-339039-6gyo9rya.txt item: #373 of 427 id: cord-339386-sxyeuiw1 author: McIntosh, Kenneth title: 157 Coronaviruses, Including Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) date: 2015-12-31 words: 8508 flesch: 39 summary: Berlin Diarrhea/Wasting Syndrome Study Group Coronaviruslike particles and other agents in the faeces of children in Efate, Vanuatu Coronavirus-like particles in adults in Melbourne, Australia Coronaviruslike particles in human gastrointestinal disease: epidemiologic, clinical, and laboratory observations An eight-year study of the viral agents of acute gastroenteritis in humans: ultrastructural observations and seasonal distribution with a major emphasis on coronavirus-like particles Isolation and characterization of current human coronavirus strains in primary human epithelia cultures reveals differences in target cell tropism Ultrastructure of human nasal epithelium during an episode of coronavirus infection Signs and symptoms in common colds Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong Haematological manifestations in patients with severe acute respiratory syndrome: retrospective analysis Clinical progression and viral load in a community outbreak of coronavirusassociated SARS pneumonia: a prospective study Detection of SARS-CoV RNA in stool samples of SARS patients by nest RT-PCR and its clinical value A major outbreak of severe acute respiratory syndrome in Hong Kong Lung pathology of fatal severe acute respiratory syndrome The clinical pathology of severe acute respiratory syndrome (SARS): a report from China Multiple organ infection and the pathogenesis of SARS Time course and cellular localization of SARS-CoV nucleoprotein and RNA in lungs from fatal cases of SARS Antigenic relationships amongst coronaviruses A case-control study of acute respiratory tract infection in general practice patients in The Netherlands Role of respiratory viruses in acute upper and lower respiratory tract illness in the first year of life: a birth cohort study Coronavirus infection in acute lower respiratory tract disease of infants Genetic variability of human coronavirus OC43-, 229E-, and NL63-like strains and their association with lower respiratory tract infections of hospitalized infants and immunocompromised patients The association of viral and bacterial respiratory infections with exacerbations of wheezing in young asthmatic children Recurrent wheezy bronchitis and viral respiratory infections Detection of rhinovirus, respiratory syncytial virus, and coronavirus infections in acute otitis media by reverse transcriptase polymerase chain reaction Coronavirus infections in military recruits: three-year study with coronavirus strains OC43 and 229E Respiratory viruses and exacerbations of asthma in adults Pan-viral screening of respiratory tract infections in adults with and without asthma reveals unexpected human coronavirus and human rhinovirus diversity Rhinovirus and coronavirus infection-associated hospitalizations among older adults A prospective, community-based study on virologic assessment among elderly people with and without symptoms of acute respiratory infection Coronavirus 229E-related pneumonia in immunocompromised patients Clinical impact of community-acquired respiratory viruses on bronchiolitis obliterans after lung transplant Clinical impact of human coronaviruses 229E and OC43 infection in diverse adult populations The United Kingdom public health response to an Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV World Health Organization. Experience in a regional hospital in Hong Kong Severe acute respiratory syndrome among children Severe acute respiratory syndrome: radiographic appearances and pattern of progression in 138 patients Imaging of severe acute respiratory syndrome in Hong Kong Severe acute respiratory syndrome: radiographic and CT findings Thin-section CT of severe acute respiratory syndrome: evaluation of 73 patients exposed to or with the disease Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome Critically ill patients with severe acute respiratory syndrome Clinical presentations and outcome of severe acute respiratory syndrome in children Severe acute respiratory syndrome and pregnancy Viral discovery and sequence recovery using DNA microarrays Corona virus induced subacute demyelinating encephalomyelitis in rats: a morphological analysis Two coronaviruses isolated from central nervous system tissue of two multiple sclerosis patients Detection of coronavirus RNA and antigen in multiple sclerosis brain Human coronavirus gene expression in the brains of multiple sclerosis patients Long-term human coronavirus-myelin cross-reactive T-cell clones derived from multiple sclerosis patients Detection of coronavirus in the central nervous system of a child with acute disseminated encephalomyelitis Diagnosis of human coronavirus infection by immunofluorescence: method and application to respiratory disease in hospitalized children Surveillance of community-acquired viral infections due to respiratory viruses in Rhone-Alpes (France) during winter 1994 to 1995 Clinical disease in children associated with newly described coronavirus subtypes Detection of a novel human coronavirus by real-time reversetranscription polymerase chain reaction Development of a standard treatment protocol for severe acute respiratory syndrome Treatment and vaccines for severe acute respiratory syndrome SARS: systematic review of treatment effects Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome coronavirus The spike protein of SARS-CoVa target for vaccine and therapeutic development keywords: children; coronavirus; cov; covs; disease; hcov; human; infection; mers; oc43; patients; respiratory; sars; severe; syndrome; syndrome coronavirus; viruses cache: cord-339386-sxyeuiw1.txt plain text: cord-339386-sxyeuiw1.txt item: #374 of 427 id: cord-339852-9rq7zzqs author: Theamboonlers, Apiradee title: Human Coronavirus Infection among Children with Acute Lower Respiratory Tract Infection in Thailand date: 2006-11-30 words: 2952 flesch: 45 summary: Acute respiratory infections: a review An outbreak of coronavirus OC43 respiratory infection in Normandy, France Coronavirus-related nosocomial viral respiratory infections in a neonatal and paediatric intensive care unit: a prospective study Impact of respiratory virus infections on persons with chronic underlying conditions Evaluation of nested polymerase chain methods for the detection of human coronaviruses 229E and OC43 Osterhaus ADME: A previously undescribed coronavirus associated with respiratory disease in humans Coronavirus derived expression systems Identifi cation of a novel coronavirus in patients with severe acute respiratory syndrome Anderson LJ; SARS Working Group: A novel coronavirus associated with severe acute respiratory syndrome Development and application of an enzyme immunoassay for coronavirus OC43 antibody in acute respiratory illness Antigenic relationships amongst coronaviruses Purifi cation and biophysical properties of human coronavirus 229E Antigenic cross-reactivity between severe acute respiratory syndrome-associated coronavirus and human coronaviruses 229E and OC43 Human coronavirus NL63 infection and other coronavirus infections in children hospitalized with acute respiratory disease in Hong Kong Human metapneumovirus infection in Thai children Direct diagnosis of human respiratory coronaviruses 229E and OC43 by the polymerase chain reaction Rhinovirus and coronavirus infection-associated hospitalizations among older adults Coronavirus infection in acute lower respiratory tract disease of infants Respiratory viral infections in the elderly Surveillance of community-acquired viral infections due to respiratory viruses in Rhône-Alpes (France) during winter 1994 to 1995 Due to the diffi culty in distinguishing between respiratory pathogens clinically and by laboratory-based analysis, studies on the impact of respiratory infections are still quite limited. keywords: acute; children; coronavirus; hcov; hcov-229e; human; infection; oc43; tract cache: cord-339852-9rq7zzqs.txt plain text: cord-339852-9rq7zzqs.txt item: #375 of 427 id: cord-339869-euikj8fv author: Cebey-López, Miriam title: Does Viral Co-Infection Influence the Severity of Acute Respiratory Infection in Children? date: 2016-04-20 words: 3327 flesch: 35 summary: Current opinion in pharmacology Comparison of multiplex PCR assays and conventional techniques for the diagnostic of respiratory virus infections in children admitted to hospital with an acute respiratory illness Clinical utility of PCR for common viruses in acute respiratory illness Viral Co-Infections in Pediatric Patients Hospitalized with Lower Tract Acute Respiratory Infections Clinical disease severity of respiratory viral co-infection versus single viral infection: a systematic review and meta-analysis Respiratory pathogens in children with and without respiratory symptoms Frequent detection of viral coinfection in children hospitalized with acute respiratory tract infection using a real-time polymerase chain reaction The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis Viral etiology of acute febrile respiratory illnesses in hospitalized children younger than 24 months Diagnostic value of respiratory virus detection in symptomatic children using real-time PCR Infection with multiple viruses is not associated with increased disease severity in children with bronchiolitis. Pediatric pulmonology Single versus dual respiratory virus infections in hospitalized infants: impact on clinical course of disease and interferon-gamma response Respiratory syncytial virus, its coinfection and paediatric lower respiratory infections. keywords: children; cohort; disease; infection; severity; study; viruses cache: cord-339869-euikj8fv.txt plain text: cord-339869-euikj8fv.txt item: #376 of 427 id: cord-340104-6n0sn5lk author: Fagbo, Shamsudeen F. title: Acute viral respiratory infections among children in MERS‐endemic Riyadh, Saudi Arabia, 2012–2013 date: 2016-07-29 words: 3332 flesch: 45 summary: Detection of bocavirus in children suffering from acute respiratory tract infections in Saudi Arabia Etiology of respiratory viral infections using rapid virus isolation methods at a tertiary care center in Riyadh, Saudi Arabia Viral etiology of respiratory infections in children in southwestern Saudi Arabia using multiplex reverse-transcriptase polymerase chain reaction Respiratory viruses in children attending a major referral centre in Saudi Arabia Bronchiolitis in Abha, Southwest Saudi Arabia: Viral etiology and predictors for hospital admission Human metapneumovirus and human coronavirus infection and pathogenicity in Saudi children hospitalized with acute respiratory illness Viruses associated with respiratory tract infections in children attending to the emergency room, king abdulaziz medical city, riyadh, Saudi Arabia Viral etiology of acute respiratory infections among Iranian Hajj pilgrims Nasal swab samples and real-time polymerase chain reaction assays in communitybased, longitudinal studies of respiratory viruses: The importance of sample integrity and quality control Respiratory tract infection during Hajj Epidemiology of 11 respiratory RNA viruses in a cohort of hospitalized children in Riyadh, Saudi Arabia Microneutralization test for respiratory syncytial virus based on an enzyme immunoassay Influenza a common viral infection among Hajj pilgrims: Time for routine surveillance and vaccination Comparison of two commercial molecular assays for simultaneous detection of respiratory viruses in clinical samples using two automatic electrophoresis detection systems Viral agents causing acute lower respiratory tract infections in hospitalized children at a tertiary care center in Saudi Arabia Lack of sensitivity of rapid antigen tests for the diagnosis of respiratory syncytial virus infection in adults Molecular epidemiology of respiratory syncytial virus transmission in childcare Bacteria and viruses that cause respiratory tract infections during the pilgrimage (Haj) season in Makkah, Saudi Arabia Molecular epidemiology of hospital outbreak of middle east respiratory syndrome Diagnosis of respiratory syncytial virus infection: Comparison of reverse transcription-PCR to viral culture and serology in adults with respiratory illness Acute respiratory tract infections: Epidemiological data, guided case management and outcome in a pediatric hospital in Riyadh Immunity to and frequency of reinfection with respiratory syncytial virus Advances in the laboratory diagnosis of viral respiratory disease Epidemiology of respiratory virus infections among infants and young children admitted to hospital in Oman The cost of community-managed viral respiratory illnesses in a cohort of healthy preschool-aged children Community epidemiology of human metapneumovirus, human coronavirus NL63, and other respiratory viruses in healthy preschool-aged children using parent-collected specimens Parent-collected respiratory specimens-A novel method for respiratory virus and vaccine efficacy research Global, regional, and national causes of child mortality: Cumulatively, respiratory virus detection was highest in December 2013 and lowest in June 2012 ( Fig. 4A and B) . keywords: children; detection; et al; infections; saudi; studies; viruses cache: cord-340104-6n0sn5lk.txt plain text: cord-340104-6n0sn5lk.txt item: #377 of 427 id: cord-340280-m1j6v33y author: Jeon, Jae‐Hyun title: Incidence and seasonality of respiratory viruses causing acute respiratory infections in the Northern United Arab Emirates date: 2019-04-07 words: 2984 flesch: 38 summary: Influenza other Respir Viruses Viral etiology of respiratory infections in children in southwestern Saudi Arabia using multiplex reverse-transcriptase polymerase chain reaction Epidemiology of respiratory virus infections among infants and young children admitted to hospital in Oman Epidemiology and seasonality of respiratory tract virus infections in the tropics The common cold Prevalence and seasonality of six respiratory viruses during five consecutive epidemic seasons in Belgium Human rhinoviruses Seasonal trends of viral respiratory tract infections in the tropics Viral etiology of acute respiratory infections among children in Porto Alegre, RS, Brazil Respiratory viral infections among pediatric inpatients and outpatients in Taiwan from 1997 to 1999 Seasonality of viral infections: mechanisms and unknowns Airborne spread of infectious agents in the indoor environment Prevention and control of seasonal influenza with vaccines: recommendations of the advisory committee on immunization practices -United States, 2017-18 influenza season Repeated influenza vaccination for preventing severe and fatal influenza infection in older adults: a multicentre case-control study Rapid and sensitive method using multiplex real-time PCR for diagnosis of infections by influenza a and influenza B viruses, respiratory syncytial virus, and parainfluenza viruses 1, 2, 3, and 4 Deviations in influenza seasonality: odd coincidence or obscure consequence? Incidence and seasonality of respiratory viruses causing acute respiratory infections in the Northern United Arab Emirates The authors declare that there are no conflict of interests. The economic burden of non-influenza-related viral respiratory tract infection in the United States Burden of respiratory viruses in patients with acute respiratory failure Evaluation of the bioactivity of influenza vaccine strains in vitro suggests that the introduction of new strains in the 2010 Southern Hemisphere trivalent influenza vaccine is associated with adverse events Seasonal variations of respiratory viruses and etiology of human rhinovirus infection in children Respiratory viral infections during the 2009-2010 winter season in Central England, UK: incidence and patterns of multiple virus co-infections Nation-wide surveillance of human acute respiratory virus infections between 2013 and 2015 in Korea Writing Committee of the WHO consultation on clinical aspects of Pandemic(H1N1)2009 influenza Latitudinal variations in seasonal activity of influenza and respiratory syncytial virus (RSV): a global comparative review Epidemiology of viral respiratory infections in a tertiary care centre in the era of molecular diagnosis Humidity and respiratory virus transmission in tropical and temperate settings Correlations between climate factors and incidence--a contributor to RSV seasonality Environmental predictors of seasonal influenza epidemics across temperate and tropical climates Incidence and risk factors for acute respiratory illnesses and influenza virus infections in Australian travellers to Asia Seasonal variations of respiratory viruses detected from children with respiratory tract infections in Riyadh, Saudi Arabia Simple estimators of the intensity of seasonal occurrence The recognition and estimation of cyclic trends Methods to assess seasonal effects in epidemiological studies of infectious diseases--exemplified by application to the occurrence of meningococcal disease Etiology of community-acquired pneumonia: increased microbiological yield with new diagnostic methods Epidemiologic and clinical features among patients hospitalized in Wisconsin with 2009 H1N1 influenza A virus infections Hospitalization Incidence, mortality, and seasonality of common respiratory viruses over a period of 15 years in a developed subtropical city Sex differences in the response to influenza virus infection: modulation by stress Multiple simultaneous viral infections in infants with acute respiratory tract infections in Spain Epidemiology and clinical outcome of virus-positive respiratory samples in ventilated patients: a prospective cohort study The burden of influenzaassociated hospitalizations in Oman Viral pneumonia Estimating the burden of influenza-associated hospitalization and deaths in Oman (2012-2015). keywords: flu; incidence; infections; study; uae; viruses cache: cord-340280-m1j6v33y.txt plain text: cord-340280-m1j6v33y.txt item: #378 of 427 id: cord-340811-w4x4falm author: Frizzelli, Annalisa title: What happens to people’s lungs when they get coronavirus disease 2019? date: 2020-05-11 words: 1781 flesch: 37 summary: The levels of inflammatory cytokines (IL-1, TNF-α) are high in the lungs of COVID-19 patients and these cytokines are strong inducers of HA-synthase-2 (HAS2) in CD31+ endothelium, EpCAM+ lung alveolar epithelial cells, and fibroblasts (13) . Recent data suggest that COVID-19 patients who are hypoxemic respond well to PEEP, indicating a crucial role for NIV, as a therapeutic measure to prevent intubation (27) . keywords: coronavirus; covid-19; disease; novel; patients; pneumonia cache: cord-340811-w4x4falm.txt plain text: cord-340811-w4x4falm.txt item: #379 of 427 id: cord-341765-ml6eo8r3 author: Widhidewi, Ni Wayan title: Identification of viral etiology of acute respiratory tract infections in children and adults in Tabanan, Bali, Indonesia date: 2020-03-25 words: 2742 flesch: 40 summary: Respiratory viruses including influenza A and B, respiratory syncytial virus (RSV), adenovirus, and parainfluenza virus are the most frequently detected viruses in patients with ARTI in Southeast Asia [8] . Singleplex PCR assays were used for detection of a panel of respiratory viruses using family-level primers for Paramyxoviridae, Herpesviridae, Coronaviridae, Hantaviridae, Adenoviridae, Arenaviridae; genus-level primers for Enterovirus, Henipavirus, Influenza A virus, Bocavirus; and Pneumovirinae sub-family primer including respiratory syncytial virus (RSV) and human metapneumovirus (HMPV). keywords: adults; arti; children; detection; infections; influenza; study; viruses cache: cord-341765-ml6eo8r3.txt plain text: cord-341765-ml6eo8r3.txt item: #380 of 427 id: cord-342133-khrljehj author: Principi, Nicola title: Bocavirus Infection in Otherwise Healthy Children with Respiratory Disease date: 2015-08-12 words: 5125 flesch: 44 summary: respiratory viral panel fast for diagnosis of respiratory virus infections MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods Datamonkey: a suite of phylogenetic analysis tools for evolutionary biology Not so different after all: a comparison of methods for detecting amino acid sites under selection Adaptation to different human populations by HIV-1 revealed by codon-based analyses Detecting individual sites subject to episodic diversifying selection Seroepidemiology of human bocavirus in Hokkaido prefecture Seroepidemiology of human bocavirus infection in Jamaica Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand Multiple versus single virus respiratory infections: viral load and clinical disease severity in hospitalized children Human bocavirus in children: mono-detection, high viral load and viraemia are associated with respiratory tract infection Human bocavirus detection in nasopharyngeal aspirates of children without clinical symptoms of respiratory infection Human bocavirus infections in hospitalized children and adults Detection of bocavirus in saliva of children with and without respiratory illness Human bocavirus 1 primary infection and shedding in infants Single detection of human bocavirus 1 with a high viral load in severe respiratory tract infections in previously healthy children Human bocavirus detection in an atopic child affected by pneumonia associated with wheezing Detection of human bocavirus in hospitalised children Human bocavirus in children suffering from acute lower respiratory tract infection in Beijing Children's Hospital Clinical characteristics of human bocavirus infections compared with other respiratory viruses in Spanish children Role of human metapneumovirus, human coronavirus NL63 and human bocavirus in infants and young children with acute wheezing Role of emerging respiratory viruses in children with severe acute wheezing Etiology of bronchiolitis in a hospitalized pediatric population: prospective multicenter study Absence of humanbocavirus in bronchoalveolar lavage fluid of lung transplant patients Neurological manifestations in acute onset of viral gastroenteritis Frequency and clinical relevance of human bocavirus infection in acute exacerbations of chronic obstructive pulmonary disease Human bocavirus in children: mono-detection, high viral load and viraemia are associated with respiratory tract infection Human bocavirus in patients with respiratory tract infection Comorbidity and high viral load linked to clinical presentation of respiratory human bocavirus infection Frequent and prolonged shedding of bocavirus in young children attending daycare Correlation between nucleotide mutation and viral loads of human bocavirus 1 in hospitalized children with respiratory tract infection Phospholipase A2-like activity of human bocavirus VP1 unique region Human bocavirus amongst an allages population hospitalised with acute lower respiratory infections in Cambodia Complete coding sequences and phylogenetic analysis of Human Bocavirus (HBoV) Human bocavirus capsid structure: insights into the structural repertoire of the parvoviridae Evolutionary relationships among parvoviruses: virus-host coevolution among autonomous primate parvoviruses and links between adeno-associated and avian parvoviruses Epidemic and molecular evolution of human bocavirus in hospitalized children with acute respiratory tract infection Rapid molecular evolution of human bocavirus revealed by Bayesian coalescent inference The study patients were classified into disease groups (i.e., acute otitis media, rhinosinusitis, pharyngitis, croup, infectious wheezing, acute bronchitis, pneumonia) on the basis of signs and/or symptoms using well-established criteria and were finally subdivided into two subgroups: upper (URTIs) and lower respiratory tract infections (LRTIs) keywords: acid; amino; bocavirus; children; disease; hbov; infection; load; samples; strains; study; tract cache: cord-342133-khrljehj.txt plain text: cord-342133-khrljehj.txt item: #381 of 427 id: cord-342314-nx0a3nvd author: Gebru, Mu’uz title: Aerobic bacteriological studies on the respiratory tracts of apparently healthy and pneumonic camels (Camelus dromedaries) in selected districts of Afar Region, Ethiopia date: 2017-11-16 words: 5043 flesch: 45 summary: prevalent in camel respiratory tract, as well as determine the antibiotic sensitivity pattern of the leading bacterial agents recovered from camels with pneumonic lungs. The majority of camel respiratory pathogens were found susceptible to norfloxacin, streptomycin, and gentamicin but resistant to the action of ampicillin and tetracycline. keywords: camels; equi; et al; isolates; lungs; pneumonic; respiratory; species; study cache: cord-342314-nx0a3nvd.txt plain text: cord-342314-nx0a3nvd.txt item: #382 of 427 id: cord-342476-0rupk21u author: van Rijn, Anneloes L. title: The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease date: 2019-10-24 words: 4038 flesch: 39 summary: Correlation between qPCR Cq value and logarithm of normalized numbers of mNGS viral reads was tested with population Pearson correlation coefficient. No correlation was found between viral reads and clinical markers. keywords: copd; exacerbations; mngs; pathogens; patients; pcr; reads; samples; study; virome; viruses cache: cord-342476-0rupk21u.txt plain text: cord-342476-0rupk21u.txt item: #383 of 427 id: cord-342649-ysossker author: Scagnolari, Carolina title: Evaluation of viral load in infants hospitalized with bronchiolitis caused by respiratory syncytial virus date: 2012-03-10 words: 3766 flesch: 36 summary: Furthermore, we found a signiWcant correlation between RSV viral load and the length of hospital stay (r = 0.16, p = 0.038), and levels of hemoglobin (r = ¡0.18, p = 0.024) or glycemia (r = 0.24, p = 0.028). To this regard, some studies revealed signiWcant association between disease severity and RSV load in nasopharyngeal secretion of infants with primary respiratory tract infection keywords: bronchiolitis; infants; load; rna; rsv; severity; virus cache: cord-342649-ysossker.txt plain text: cord-342649-ysossker.txt item: #384 of 427 id: cord-342853-n3e6yawi author: Naghipour, Mohammadreza title: Human bocavirus in Iranian children with acute respiratory infections date: 2007-03-26 words: 2119 flesch: 48 summary: key: cord-342853-n3e6yawi authors: Naghipour, Mohammadreza; Cuevas, Luis E.; Bakhshinejad, Tahereh; Dove, Winifred; Hart, C. Anthony title: Human bocavirus in Iranian children with acute respiratory infections date: 2007-03-26 journal: J Med Virol DOI: 10.1002/jmv.20815 sha: doc_id: 342853 cord_uid: n3e6yawi Human bocavirus (HBoV), a virus discovered in Sweden in 2005, has been associated with acute respiratory infections in young children and subsequent reports suggest that HBoV may have a worldwide distribution. This report describes the frequency and clinical presentation of HBoV in 261 Iranian children<5 years old with acute respiratory infections attending two regional hospitals in Rasht, Iran in the winter of 2003–2004. keywords: children; hbov; infections cache: cord-342853-n3e6yawi.txt plain text: cord-342853-n3e6yawi.txt item: #385 of 427 id: cord-342915-r9kv67we author: Hayden, Frederick G. title: Advances in antivirals for non‐influenza respiratory virus infections date: 2013-11-01 words: 5757 flesch: 23 summary: Recent studies have provided encouraging results in treating respiratory syncytial virus infections in lung transplant recipients, serious parainfluenza virus and adenovirus infections in immunocompromised hosts, and rhinovirus colds in outpatient asthmatics. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection A single asparagine-linked glycosylation site of the severe acute respiratory syndrome coronavirus spike glycoprotein facilitates inhibition by mannose-binding lectin through multiple mechanisms High-dose mannose-binding lectin therapy for Ebola virus infection Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis Mortality associated with influenza and respiratory syncytial virus in the United States Antibodies for prevention and treatment of respiratory syncytial virus infections in children Respiratory syncytial virus Antiviral therapy of respiratory viruses in haematopoietic stem cell transplant recipients Management of RSV infections in adult recipients of hematopoietic stem cell transplantation Outcome of Respiratory Syncytial Virus Lower Respiratory Tract Disease in Hematopoietic Cell Transplant Recipients Receiving Aerosolized Ribavirin: Significance of Stem Cell Source and Oxygen Requirement keywords: coronavirus; cov; human; infections; influenza; interferon; patients; ribavirin; rsv; sars; studies; treatment; virus; viruses cache: cord-342915-r9kv67we.txt plain text: cord-342915-r9kv67we.txt item: #386 of 427 id: cord-342993-deuytbml author: Maffey, Alberto F. title: Viruses and atypical bacteria associated with asthma exacerbations in hospitalized children date: 2010-05-06 words: 3286 flesch: 41 summary: The role of viral infections in the natural history of asthma Early identification of atopy in the prediction of persistent asthma in children Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach A clinical index to define risk of asthma in young children with recurrent wheezing Global strategy for asthma management and prevention: GINA executive summary New respiratory viruses in children 2 months to 3 years old with recurrent wheeze Prevalence of viral respiratory tract infections in children with asthma Role of viruses and atypical bacteria in exacerbations of asthma in hospitalized children: a prospective study in the Nord-Pas de Calais Region (France) Comparison of real-time PCR assays with fluorescentantibody for diagnosis of respiratory virus infections in children Human picornavirus and coronavirus RNA in nasopharynx of children without concurrent respiratory symptoms Respiratory syncytial virus infection in elderly and high-risk adults Community study of role of viral infections in exacerbations of asthma in 9-11 year old children Prednisolone reduces recurrent wheezing alter a first wheezing episode associated with rhinovirus infection or eczema Influenza virus and acute asthma in children Respiratory picornaviruses and respiratory syncytial virus as causative agents of acute expiratory wheezing in children Importance of acute Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with wheezing The effect of telithromycin in acute exacerbations of asthma Impact of human metapneumovirus and respiratory syncytial virus co-infection in severe bronchiolitis Absence of human Metapneumovirus co-infection in cases of severe respiratory syncytial virus infection A comparison of nested polymerase chain reaction and immunofluorescence for the diagnosis of respiratory infections in children with bronchiolitis and the implications for a cohorting strategy Respiratory viruses seasonality in children under five years of age in Buenos Aires, Argentina. key: cord-342993-deuytbml authors: Maffey, Alberto F.; Barrero, Paola R.; Venialgo, Carolina; Fernández, Francisco; Fuse, Valentina A.; Saia, Mariana; Villalba, Analía; Rodríguez Fermepin, Marcelo; Teper, Alejandro M.; Mistchenko, Alicia S. title: Viruses and atypical bacteria associated with asthma exacerbations in hospitalized children date: 2010-05-06 journal: Pediatr Pulmonol DOI: 10.1002/ppul.21236 sha: doc_id: 342993 cord_uid: deuytbml OBJECTIVES AND WORKING HYPOTHESIS: To evaluate the prevalence of respiratory viruses Mycoplasma pneumoniae and Chlamydophila pneumoniae and gain insight into their seasonal circulation pattern in children with acute asthma exacerbations in a temperate southern hemisphere region. keywords: age; asthma; children; patients; pneumoniae; viruses; years cache: cord-342993-deuytbml.txt plain text: cord-342993-deuytbml.txt item: #387 of 427 id: cord-343042-9mue4eiv author: Bertozzi, Giuseppe title: Mistrial or Misdiagnosis: The Importance of Autopsy and Histopathological Examination in Cases of Sudden Infant Bronchiolitis-Related Death date: 2020-05-27 words: 2455 flesch: 31 summary: In this context, the purpose of this manuscript is to present a case series of infant deaths in different emergency-related facilities (ambulances, emergency rooms) denounced by relatives. key: cord-343042-9mue4eiv authors: Bertozzi, Giuseppe; Maglietta, Francesca; Baldari, Benedetta; Besi, Livia; Torsello, Alessandra; Di Gioia, Cira Rosaria Tiziana; Sessa, Francesco; Aromatario, Mariarosaria; Cipolloni, Luigi title: Mistrial or Misdiagnosis: The Importance of Autopsy and Histopathological Examination in Cases of Sudden Infant Bronchiolitis-Related Death date: 2020-05-27 journal: keywords: autopsy; bronchiolitis; cases; claims; data; death; medical cache: cord-343042-9mue4eiv.txt plain text: cord-343042-9mue4eiv.txt item: #388 of 427 id: cord-343050-1pfqgvie author: Huang, Qiu Sue title: Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance date: 2015-06-09 words: 6057 flesch: 19 summary: [67] It was designed to monitor trends in severe influenza disease and to best capture the majority of influenza respiratory disease to estimate the burden of influenza-associated respiratory hospitalizations, and risk factors for severe disease. However, the evidence to support valid and precise estimates of influenza disease burden globally remains weak with low quality, partly due to the short duration of studies and the heterogeneity of study settings and methods (statistical modelling, active versus passive case findings, virological versus clinical detection). keywords: associated; burden; disease; effectiveness; infection; influenza; pandemic; risk; sari; shivers; surveillance; vaccine cache: cord-343050-1pfqgvie.txt plain text: cord-343050-1pfqgvie.txt item: #389 of 427 id: cord-343074-dsubeaso author: Lee, Wan‐Ji title: Molecular epidemiology of a post‐influenza pandemic outbreak of acute respiratory infections in Korea caused by human adenovirus type 3 date: 2014-06-01 words: 3537 flesch: 40 summary: In the same context, respiratory HAdV infections can be identified from patients with an upper respiratory tract infection throughout the entire year, with an average detection rate of 4% in Korea This is believed to be the first report of a nationwide outbreak of respiratory adenovirus infections in Korea. keywords: adenovirus; hadv; hadv-3; infections; korea; outbreak cache: cord-343074-dsubeaso.txt plain text: cord-343074-dsubeaso.txt item: #390 of 427 id: cord-343325-cbrly7f5 author: Denault, André Y. title: A proposed lung ultrasound and phenotypic algorithm for the care of COVID-19 patients with acute respiratory failure date: 2020-05-21 words: 4029 flesch: 35 summary: medRxiv preprint Acute pulmonary embolism in COVID-19 patients on CT angiography and relationship to D-dimer levels Incidence of thrombotic complications in critically ill ICU patients with COVID-19 COVID-19 complicated by acute pulmonary embolism and right-sided heart failure Thrombotic events in SARS-CoV-2 patients: an urgent call for ultrasound screening Lung ultrasound for daily monitoring of ARDS patients on extracorporeal membrane oxygenation: preliminary experience Impact of point-of-care ultrasound on the hospital length of stay for internal medicine inpatients with cardiopulmonary diagnosis at admission: study protocol of a randomized controlled trial-the IMFCU-1 (Internal Medicine Focused Clinical Ultrasound) study A bedside ultrasound sign ruling out pneumothorax in the critically ill. 5 Abnormalities were also observed on chest radiography, such as bilateral peripheral consolidation and ground-glass opacities, 6 as well with the use of lung ultrasound. keywords: acute; care; covid-19; failure; index; lung; patients; respiratory; type; ultrasound cache: cord-343325-cbrly7f5.txt plain text: cord-343325-cbrly7f5.txt item: #391 of 427 id: cord-343365-4y9fedcr author: Chang, Christopher title: Unmet Needs in Respiratory Diseases: “You Can’t Know Where You Are Going Until You Know Where You Have Been”—Anonymous date: 2013-11-30 words: 7303 flesch: 45 summary: key: cord-343365-4y9fedcr authors: Chang, Christopher title: Unmet Needs in Respiratory Diseases: “You Can’t Know Where You Are Going Until You Know Where You Have Been”—Anonymous date: 2013-11-30 journal: Clin Rev Allergy Immunol DOI: 10.1007/s12016-013-8399-2 sha: doc_id: 343365 cord_uid: 4y9fedcr The care of patients with respiratory diseases has improved vastly in the past 50 years. keywords: asthma; biomarkers; development; disease; fibrosis; gene; patients; pertussis; rsv; therapy; treatment; tuberculosis; vaccine; virus; years cache: cord-343365-4y9fedcr.txt plain text: cord-343365-4y9fedcr.txt item: #392 of 427 id: cord-343390-y903mxcj author: Hoppe, Ingrid Bortolin Affonso Lux title: Bovine respiratory syncytial virus seroprevalence and risk factors in non-vaccinated dairy cattle herds in Brazil date: 2018-06-27 words: 2919 flesch: 46 summary: Bovine respiratory syncytial virus Bovine respiratory syncytial virus (BRSV): a review Bovine respiratory syncytial virus) infection: its pathogenesis, diagnosis, prevention and treatment Seroepizootiologic study of bovine respiratory syncytial virus in a dairy herd Respiratory syncytial virus: brief review Identificación de agentes virales por inmunohistoquímica en enfermedades respiratórias de bovinos en corral de engorda Severe respiratory disease in dairy cows caused by infection with bovine respiratory syncytial virus Bovine respiratory syncytial virus seroprevalence and risk factors in endemic dairy cattle herds Risk factors for epidemic respiratory disease in Norwegian cattle herds Risk factors for seropositivity to bovine coronavirus and bovine respiratory syncytial virus in dairy herds Seroprevalence of bovine respiratory viruses in North-Western Turkey Bovine respiratory syncytial virus: first serological evidence in Uruguay Detection on antibodies and risk factors for infection with bovine respiratory syncytial virus and parainfluenza virus 3 in dual purpose farms in Colima Seroprevalence to bovine virus diarrhoea virus and other viruses of the bovine respiratory complex in Venezuela (Apure state) Prevalence of and risk factors for bovine respiratory syncytial virus (BRSV) infection in non-vaccinated dairy and dual-purpose cattle herds in Ecuador Detection of antibodies and risk factors for infections with bovine respiratory syncytial vírus and parainfluenza virus-3 in beef cattle of Yucatan Detection of bovine respiratory syncytial virus in calves of Rio Grande do Sul Detection of antibodies against bovine respiratory syncytial virus (BRSV) in dairy cattle with different prevalences of bovine herpesvirus type 1 (BHV-1) in São Paulo State Vírus respiratório sincicial dos bovinos (BRSV): Situação no Brasil Serological evidence of bovine respiratory syncytial virus in Brazil Produção da Pecuária Municipal Campinas: UNICAMP Encuestas por muestreo para estudios epidemiologicos en poblaciones animales Simple method of estimating 50 per cent end point Dynamics of bovine respiratory syncytial virus infections: a longitudinal epidemiological study in dairy herds A longitudinal study of the dynamics of bovine corona virus and respiratory syncytial virus infections in dairy herds Herpesvirus bovino tipo 1 (HVB-1): revisão e situação atual no Brasil A infecção pelo vírus da diarreia viral bovina (BVDV) This study aimed to characterize the epidemiology of BRSV infection in dairy cattle herds of São Paulo State, Brazil, using serological and risk factors analyses. keywords: animals; bovine; brsv; factors; herds; risk; virus cache: cord-343390-y903mxcj.txt plain text: cord-343390-y903mxcj.txt item: #393 of 427 id: cord-344271-5aynmdsk author: de Souza Luna, Luciano Kleber title: Spectrum of Viruses and Atypical Bacteria in Intercontinental Air Travelers with Symptoms of Acute Respiratory Infection date: 2007-03-01 words: 2308 flesch: 51 summary: Respiratory infections during air travel Aircraft cabin air recirculation and symptoms of the common cold Prevalence of respiratory symptoms among female flight attendants and teachers Transmission of infectious diseases during commercial air travel Community-acquired pneumonia Identification of a novel coronavirus in patients with severe acute respiratory syndrome Internally controlled real-time PCR monitoring of adenovirus DNA load in serum or plasma of transplant recipients Amplicon sequencing and improved detection of human rhinovirus in respiratory samples Cloning of a human parvovirus by molecular screening of respiratory tract samples Single-run, parallel detection of DNA from three pneumonia-producing bacteria by real-time polymerase chain reaction Evidence of human coronavirus HKU1 and human bocavirus in Australian children Detection of human bocavirus in Japanese children with lower respiratory tract infections Enhanced identification of viral and atypical bacterial pathogens in lower respiratory tract samples with nucleic acid amplification tests Surveillance of respiratory virus infections in adult hospital admissions using rapid methods Characterization of viral agents causing acute respiratory infection in a San Francisco University Medical Center Clinic during the influenza season Respiratory samples ( ) from n p 214 172 patients were available. keywords: contact; detection; flight; patients; samples cache: cord-344271-5aynmdsk.txt plain text: cord-344271-5aynmdsk.txt item: #394 of 427 id: cord-344889-1y4ieamp author: Cameron, Robert J. title: Virus infection in exacerbations of chronic obstructive pulmonary disease requiring ventilation date: 2006-05-24 words: 4314 flesch: 42 summary: An attempt to evaluate the relationship Infectious exacerbations of chronic obstructive pulmonary disease associated with respiratory viruses and non-typeable Haemophilus influenzae Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study Bronchial microbial patterns in severe exacerbations of chronic obstructive pulmonary disease (COPD) requiring mechanical ventilation Characterization of distal bronchial microflora during acute exacerbation of chronic bronchitis. Role of inflammatory cells and mediators A model of viral wheeze in nonasthmatic adults: symptoms and physiology Virus-induced asthma attacks Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children Respiratory picornaviruses and respiratory syncytial virus as causative agents of acute expiratory wheezing in children Field's virology, 4th edn Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper Noninvasive ventilation in acute respiratory failure Evaluation of antimicrobial treatment in mechanically ventilated patients with severe chronic obstructive pulmonary disease exacerbations Noninvasive positivepressure ventilation via face mask during bronchoscopy with BAL in high-risk hypoxemic patients Evaluation of a quantitative real-time PCR for the detection of respiratory syncytial virus in pulmonary diseases Detection of rhinovirus in induced sputum at exacerbation of chronic obstructive pulmonary disease Recent advances in diagnosis and management of chronic bronchitis and emphysema Evidencebased approach to acute exacerbations of COPD Exacerbations of chronic obstructive pulmonary disease: when are bacteria important? Impact of sputum bacteria on airway inflammation and health status in clinical stable COPD Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations Natural and experimental rhinovirus infections of the lower respiratory tract Virus-induced airway hyperresponsiveness in man Low grade rhinovirus infection induces a prolonged release of IL-8 in pulmonary epithelium Detection of rhinovirus RNA in lower airway cells during experimentally induced infection Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease Lower respiratory viral illnesses: improved diagnosis by molecular methods and clinical impact Impact of respiratory virus infections on persons with chronic underlying conditions Epidemiology and treatment of chronic bronchitis and its exacerbations Respiratory viral infections in adults Respiratory viral infections in adults with and without chronic obstructive pulmonary disease Rapid and sensitive routine detection of all members of the genus enterovirus in different clinical specimens by real-time PCR keywords: cases; chronic; copd; exacerbations; infection; patients; pcr; study; virus cache: cord-344889-1y4ieamp.txt plain text: cord-344889-1y4ieamp.txt item: #395 of 427 id: cord-345211-4ivqlsgt author: Murdoch, David R. title: How recent advances in molecular tests could impact the diagnosis of pneumonia date: 2016-03-07 words: 5996 flesch: 30 summary: A wide variety of microorganisms are listed as pneumonia pathogens key: cord-345211-4ivqlsgt authors: Murdoch, David R. title: How recent advances in molecular tests could impact the diagnosis of pneumonia date: 2016-03-07 journal: Expert Rev Mol Diagn DOI: 10.1586/14737159.2016.1156536 sha: doc_id: 345211 cord_uid: 4ivqlsgt Molecular diagnostic tests have been the single major development in pneumonia diagnostics over recent years. keywords: children; detection; diagnostic; disease; etiology; nats; pathogens; pcr; pneumococcal; pneumonia; tests cache: cord-345211-4ivqlsgt.txt plain text: cord-345211-4ivqlsgt.txt item: #396 of 427 id: cord-345472-qrddwebe author: Sebina, Ismail title: The Contribution of Neutrophils to the Pathogenesis of RSV Bronchiolitis date: 2020-07-27 words: 8213 flesch: 23 summary: Mice lacking CCL3 or its receptor CCR1 display significantly reduced numbers of airway neutrophils in response to infection with PVM Intriguingly, in an ex vivo model, this process was diminished, with an agonistic antibody directed against LAIR-1, which was shown to be elevated on airway neutrophils but not on circulating neutrophils [117] . keywords: airway; asthma; bronchiolitis; cells; disease; function; infants; infection; inflammation; lung; mice; neutrophil; production; rsv; rsv bronchiolitis; virus cache: cord-345472-qrddwebe.txt plain text: cord-345472-qrddwebe.txt item: #397 of 427 id: cord-346096-aml84iv1 author: Bailey, Emily S. title: Molecular surveillance of respiratory viruses with bioaerosol sampling in an airport date: 2018-09-17 words: 2507 flesch: 42 summary: key: cord-346096-aml84iv1 authors: Bailey, Emily S.; Choi, Jessica Y.; Zemke, Juliana; Yondon, Myagmarsukh; Gray, Gregory C. title: Molecular surveillance of respiratory viruses with bioaerosol sampling in an airport date: 2018-09-17 journal: Trop Dis Travel Med Vaccines DOI: 10.1186/s40794-018-0071-7 sha: doc_id: 346096 cord_uid: aml84iv1 Recognizing that crowded, high-traffic airports and airplanes have been implicated in respiratory disease transmission, we partnered with administrators of Raleigh Durham International Airport (RDU) in conducting a pilot study of aerosol surveillance for respiratory viruses at RDU. This bioaerosol sampling technique has been adapted for respiratory virus screening in swine production facilities [5] , poultry markets keywords: adenovirus; aerosol; airport; human; influenza; samples; sampling; study; viruses cache: cord-346096-aml84iv1.txt plain text: cord-346096-aml84iv1.txt item: #398 of 427 id: cord-346253-0mnsm6s4 author: Ahanchian, Hamid title: Respiratory viral infections in children with asthma: do they matter and can we prevent them? date: 2012-09-13 words: 7750 flesch: 29 summary: key: cord-346253-0mnsm6s4 authors: Ahanchian, Hamid; Jones, Carmen M; Chen, Yueh-sheng; Sly, Peter D title: Respiratory viral infections in children with asthma: do they matter and can we prevent them? Viral respiratory infections are the major cause of acute asthma exacerbations and may contribute to asthma inception in high risk young children with susceptible genetic background. keywords: airway; asthma; cells; childhood; children; cold; exacerbations; hrv; infections; prevention; probiotics; rhinovirus; risk; rsv; tract; trial; vitamin cache: cord-346253-0mnsm6s4.txt plain text: cord-346253-0mnsm6s4.txt item: #399 of 427 id: cord-346290-my8ow5ee author: Nelson, Philipp P. title: Respiratory Viral Pathogens date: 2020-05-28 words: 4163 flesch: 37 summary: Respiratory virus infection causes an increase in both vascular permeability mediated by vasoactive amines and glandular secretion under the influence of cholinergic reflexes and neuropeptides. Human parainfluenza viruses (HPIVs) are respiratory viruses in the family of Paramyxoviridae. keywords: et al; genome; genus; host; human; infections; influenza; protein; respiratory; viruses cache: cord-346290-my8ow5ee.txt plain text: cord-346290-my8ow5ee.txt item: #400 of 427 id: cord-346539-kxnrf5g5 author: Riggioni, Carmen title: A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2 date: 2020-06-14 words: 15806 flesch: 41 summary: All rights reserved hypersensitivity reactions to drugs may occur more often during the pandemic due to the increased use of drugs and drug interactions, which can result in morbilliform rash, erythroderma, Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia Effect of changing case definitions for COVID-19 on the epidemic curve and transmission parameters in mainland China: a modelling study Presumed Asymptomatic Carrier Transmission of COVID-19 Eleven faces of coronavirus disease 2019 The proximal origin of SARS-CoV-2 Phylogenetic network analysis of SARS-CoV-2 genomes Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2 SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor Distribution of ACE2, CD147, cyclophilins, CD26 and other SARS-CoV-2 associated molecules in various human tissues and immune cells in health and disease SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses Distribution of ACE2, CD147, CD26 and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes The potential danger of suboptimal antibody responses in COVID-19 Resistance to coronavirus infection in amino peptidase N-deficient pigs Mammalian Glutamyl Aminopeptidase Genes (ENPEP) and Proteins: Comparative Studies of a Major Contributor to Arterial Hypertension Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26 ACE1 polymorphism and progression of SARS Longitudinal profile of antibodies against SARS-coronavirus in SARS patients and their clinical significance Antibody responses to SARS-CoV-2 in patients with COVID-19 Long-term coexistence of SARS-CoV-2 with antibody response in COVID-19 patients Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients The Multifaceted B Cell Response in Allergen Immunotherapy COVID-19 Autopsies EAACI position paper on how to classify cutaneous manifestations of drug hypersensitivity Lung eosinophils-A novel virus sink that is defective in asthma? On the other hand, a retrospective study on SARS patients in Hong Kong suggested a better survival rate in patients treated with prednisolone for milder pneumonia or methylprednisolone in more severe cases. keywords: ace2; article; asthma; cases; cells; children; copyright; coronavirus; cov-2; covid-19; covid-19 patients; data; days; disease; figure; human; infection; non; pandemic; patients; reserved; responses; rights; risk; sars; studies; study; transmission; treatment; use cache: cord-346539-kxnrf5g5.txt plain text: cord-346539-kxnrf5g5.txt item: #401 of 427 id: cord-346673-kyc1wks5 author: NICKBAKHSH, S. title: Extensive multiplex PCR diagnostics reveal new insights into the epidemiology of viral respiratory infections date: 2016-03-02 words: 5419 flesch: 36 summary: The resultant accumulation of data provides a novel opportunity to investigate viral respiratory infections in a more comprehensive fashion than previously possible. Viral respiratory infections were more likely to be detected in winter, in children aged 1-5 years, and in GP attendees, irrespective of the other factors. keywords: age; episodes; infections; influenza; patient; virus; viruses; years cache: cord-346673-kyc1wks5.txt plain text: cord-346673-kyc1wks5.txt item: #402 of 427 id: cord-346887-dl0wc4u2 author: Cho, Hye Jung title: Respiratory viruses in neonates hospitalized with acute lower respiratory tract infections date: 2012-12-11 words: 3078 flesch: 48 summary: Viruses in community-acquired pneumonia in children aged less than 3 years old: High rate of viral coinfection Role of rhinovirus in hospitalized infants with respiratory tract infections in Spain Viral etiology of acute respiratory infections with cough in infancy: A community-based birth cohort study Estimates of world-wide distribution of child deaths from acute respiratory infections Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: A systematic review and meta-analysis Risk factors in children hospitalized with RSV bronchiolitis versus non-RSV bronchiolitis Respiratory syncytial virus-associated hospitalizations among infants and young children in the United States Risk factors for severe RSV-induced lower respiratory tract infection over four consecutive epidemics Epidemiology and prevention of respiratory syncytial virus infections among infants and young children Hospitalization rates for respiratory syncytial virus infection in premature infants born during two consecutive seasons FLIP-2 Study: Risk factors linked to respiratory syncytial virus infection requiring hospitalization in premature infants born in Spain at a gestational age of 32 to 35 weeks Clinical prediction rule for RSV bronchiolitis in healthy newborns: Prognostic birth cohort study Frequent detection of viral coinfection in children hospitalized with acute respiratory tract infection using a real-time polymerase chain reaction Clinical characteristics of acute lower respiratory tract infection due to 13 respiratory viruses detected by multiplex PCR in children Respiratory syncytial virus and human rhinoviruses are the major causes of severe lower respiratory tract infections in Kuwait Rhinovirus associated with severe lower respiratory tract infections in children Respiratory pathogens in children with and without respiratory symptoms Rhinovirus transmission within families with children: Incidence of symptomatic and asymptomatic infections Characteristics of hospitalized children with 2009 pandemic influenza A (H1N1): A multicenter study in Korea The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis Mixed respiratory virus infections The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children Trends in chronologic age and infant respiratory syncytial virus hospitalization: An 8-year cohort study Clinical and epidemiological comparison of human metapneumovirus and respiratory syncytial virus in seoul Nosocomial infection: A risk factor for a complicated course in children with respiratory syncytial virus infection: Results from a prospective multicenter German surveillance study Respiratory syncytial virus infection in 406 hospitalized premature infants: Results from a prospective German multicentre database Clinical relevance of prevention of respiratory syncytial virus lower respiratory tract infection in preterm infants born between 33 and 35 weeks gestational age Respiratory syncytial virus infections in hospitalized infants: Association between viral load, virus subgroup, and disease severity The Pediatric Investigators Collaborative Network on Infections in Canada study of predictors of hospitalization for respiratory syncytial virus infection for infants born at 33 through 35 completed weeks of gestation Effect of prematurity on respiratory syncytial virus hospital resource use and outcomes Acute lower respiratory tract infection due to respiratory syncytial virus in a group of Egyptian children under 5 years of age Prevention of serious respiratory syncytial virus-related illness. keywords: children; infants; infections; neonates; rsv; study; virus cache: cord-346887-dl0wc4u2.txt plain text: cord-346887-dl0wc4u2.txt item: #403 of 427 id: cord-347246-0vofftmj author: Everitt, J I title: Infectious diseases of the upper respiratory tract: implications for toxicology studies. date: 1990-04-17 words: 3576 flesch: 24 summary: Recent Results Cancer Res Mycoplasmal infections: disease pathogenesis, implications for biomedical research, and control The pathogenic potential of mycoplasmas: Mycoplasma pulmonis as a model Murine respiratory mycoplasmosis, upper respiratory tract, rat Enhancement of natural and experimental respiratory mycoplasmosis in rats by hexamethylphosphoramide Pulmonary response to inhaled hexamethylphosphoramide in rats Y Carcinogenic and toxicologic effects of inhaled ethylene oxide and propylene oxide in F344 rats isolation, propagation, and characterization of a newly recognized pathogen, cilia-associated respiratory bacillus of rats, an etiological agent of chronic respiratory disease Cilia-associated respiratory (CAR) bacillus infection of obese mice Aspergillus rhinitis in Wistar (Crl:(WI)BR) rats Toxicology: complications caused by murine viruses and mycoplasmas The influence of infection on the metabolism of foreign compounds The effect of cyclophosphamide on Sendai virus infection of mice Effect of PR-8 viral respiratory infection on benzo Possible consequences of cytochrome P-450-dependent monooxygenases in nasal tissues Research complications and state of knowledge of rodent coronaviruses Mouse hepatitis S in weanling mice following intranasal inoculation Sendai virus infection has been well described for mice (11) (12) (13) , and recently the course of experimental infection in the rat has been reported (14) . keywords: infection; lesions; mice; nasal; rats; sendai; studies; tract; virus cache: cord-347246-0vofftmj.txt plain text: cord-347246-0vofftmj.txt item: #404 of 427 id: cord-347255-fl9lur4h author: May, Larissa title: Rapid Multiplex Testing for Upper Respiratory Pathogens in the Emergency Department: A Randomized Controlled Trial date: 2019-11-05 words: 4067 flesch: 34 summary: Thus, we conducted a randomized clinical trial of the FilmArray RP vs usual care in ED patients with signs or symptoms of upper respiratory infection or influenza-like illness. We conducted a prospective, patient-oriented, pilot randomized clinical trial of rapid multiplex respiratory pathogen testing (RP test group) vs usual care (usual care or control group) in a level 1 emergency department with limited use of single-organism rapid point-of-care tests at a quaternary referral medical center. keywords: antibiotic; care; influenza; patients; results; study; testing cache: cord-347255-fl9lur4h.txt plain text: cord-347255-fl9lur4h.txt item: #405 of 427 id: cord-347262-q88g1561 author: Schutzer‐Weissmann, J. title: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection risk during elective peri‐operative care: a narrative review date: 2020-07-11 words: 4759 flesch: 31 summary: Chung-Hua Liu Hsing Ping Hsueh Risk factors for SARS transmission from patients requiring intubation: A multicentre investigation in Toronto Transmission of severe acute respiratory syndrome during intubation and mechanical ventilation SARS among Critical Care Nurses Illness in intensive care staff after brief exposure to severe acute respiratory syndrome Assessing the evidence base for medical procedures which create a higher risk of respiratory infection transmission from patient to healthcare worker COVID-19 and risks posed to personnel during endotracheal intubation Exposure to a surrogate measure of contamination from simulated patients by Emergency Department personnel wearing Personal Protective Equipment Toward understanding the risk of secondary airborne infection: emission of respirable pathogens Evaluation of bioaerosol exposures during hospital bronchoscopy examinations Droplet fate in indoor environments, or can we prevent the spread of infection? Exhaled droplets due to talking and coughing Size distribution and sites of origin of droplets expelled from the human respiratory tract during expiratory activities Airborne transmission of severe acute respiratory syndrome coronavirus-2 to healthcare workers: a narrative review Turbulent Gas Clouds and Respiratory Pathogen Emissions: The studies upon which the WHO list of aerosol-generating procedures is based do not provide any direct evidence that tracheal intubation itself increases the risk of SARS transmission. keywords: aerosol; cov-2; covid-19; healthcare; infection; intubation; risk; sars; tracheal; transmission; workers cache: cord-347262-q88g1561.txt plain text: cord-347262-q88g1561.txt item: #406 of 427 id: cord-347465-yu6oj30v author: Kurskaya, Olga title: Viral etiology of acute respiratory infections in hospitalized children in Novosibirsk City, Russia (2013 – 2017) date: 2018-09-18 words: 3385 flesch: 39 summary: Prevalence of respiratory viruses among children hospitalized from respiratory infections in Shenzhen, China Estimates of world-wide distribution of child deaths from acute respiratory infections Role of respiratory viruses in acute upper and lower respiratory tract illness in the first year of life: a birth cohort study Multiplex real-time PCR for detection of respiratory tract infections Epidemiology of human respiratory viruses in children with acute respiratory tract infections in Jinan, China Respiratory virus infections in hospitalized children and adults in Lao PDR. [32] and it may be due to decreased sensitivity to respiratory virus infections in older children. keywords: age; aris; children; infections; influenza; respiratory; viruses cache: cord-347465-yu6oj30v.txt plain text: cord-347465-yu6oj30v.txt item: #407 of 427 id: cord-347509-2ysw9a0a author: Aronen, Matti title: Virus Etiology of Airway Illness in Elderly Adults date: 2016-06-20 words: 1759 flesch: 38 summary: In the 729 episodes, age (range 65-100) was not associated with detection of respiratory viruses (P = .49), but the presence of a virus, especially influenza (odds ratio (OR) = 1.02, 95% confidence interval (CI) = 7.70, 95% CI = 2.73-21.72), two or more major comorbidities (CIRS-G Grade 3 or 4) (aOR = 2.72, 95% CI = 1.26-5.87), MMSE score less Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men Is frailty associated with cardiovascular drug use? Frailty in older adults: Evidence for a phenotype Antihypertensive medications and differences in muscle mass in older persons: The Health, Aging and Body Composition Study Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: An observational study Effect of perindopril on physical function in elderly people with functional impairment: A randomized controlled trial Association between frailty and carotid central structure changes: The Three-City Study Associations of central and brachial blood pressure with cognitive function: A population-based study Cognitive function in the prefrailty and frailty syndrome Antihypertensive drugs, prevention of cognitive decline and dementia: A systematic review of observational studies, randomized controlled trials and meta-analyses, with discussion of potential mechanisms A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants New respiratory viruses and the elderly The diagnosis of viral respiratory disease in older adults Respiratory viral infections in the elderly Identification of respiratory viruses in asymptomatic subjects: Asymptomatic respiratory viral infections Human bocavirus: A novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand Respiratory viruses in bronchoalveolar lavage: A hospital-based cohort study in adults Human bocavirus-the first 5 years Obesity as a risk factor for severe influenza-like illness The weight of obesity on the human immune response to vaccination keywords: adults; information; symptoms; virus; viruses cache: cord-347509-2ysw9a0a.txt plain text: cord-347509-2ysw9a0a.txt item: #408 of 427 id: cord-348490-dqabq6d8 author: Maeder, Muriel N. title: Sickle-cell disease in febrile children living in a rural village of Madagascar and association with malaria and respiratory infections date: 2016-12-01 words: 4291 flesch: 44 summary: Prevalence of SCD among febrile children was 2.4% (95% CI, 1.5–3.7%) and that of SCT was 23.8% (95% CI, 20.9–26.9%). However, the clinical significance of viral detection in biological samples from patients with respiratory infections remains often unclear. keywords: cell; children; infection; malaria; patients; scd; sickle; study cache: cord-348490-dqabq6d8.txt plain text: cord-348490-dqabq6d8.txt item: #409 of 427 id: cord-349226-xzlc1pni author: Khatiwada, Saroj title: Lung microbiome and coronavirus disease 2019 (COVID-19): possible link and implications date: 2020-08-05 words: 4317 flesch: 31 summary: The COVID-19 disease begins with the invasion of lungs by SARS-CoV-2 virus, and the major complications that develop subsequently are related to lung infection and immune response generation, therefore, lung microbiome might play an important role from initiation to the progression of this disease [16] . In lung diseases, these factors can change, and therefore overgrowth of one species with reduction of microbial diversity occurs (shown in figure 1 ) keywords: cells; covid-19; disease; immunity; infection; lung; microbiome; patients; pneumonia; sars cache: cord-349226-xzlc1pni.txt plain text: cord-349226-xzlc1pni.txt item: #410 of 427 id: cord-349279-wbb7h2zu author: Walker, Gregory J. title: Viruses associated with acute respiratory infection in a community‐based cohort of healthy New Zealand children date: 2019-05-07 words: 2771 flesch: 39 summary: 19 Respiratory viruses cause significant morbidity, particularly for Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis Respiratory viruses and influenza-like illness: epidemiology and outcomes in children aged 6 months to 10 years in a multi-country population sample Community epidemiology of human metapneumovirus, human coronavirus NL63, and other respiratory viruses in healthy preschool-aged children using parentcollected specimens Community-wide, contemporaneous circulation of a broad spectrum of human rhinoviruses in healthy Australian preschool-aged children during a 12-month period Epidemiology of human respiratory viruses in children with acute respiratory tract infection in a 3-year hospital-based survey in Northern Italy Viral bacterial coinfection of the respiratory tract during early childhood The role of infections and coinfections with newly identified and emerging respiratory viruses in children Molecular diagnosis of respiratory viruses New molecular virus detection methods and their clinical value in lower respiratory tract infections in children Respiratory viral detections during symptomatic and asymptomatic periods in young Andean children Environmental factors affecting the transmission of respiratory viruses Impact of pollution, climate, and sociodemographic factors on spatiotemporal dynamics of seasonal respiratory viruses Incidence and viral aetiologies of acute respiratory illnesses (ARIs) in the United States: a population-based study Implementing hospital-based surveillance for severe acute respiratory infections caused by influenza and other respiratory pathogens in New Zealand Southern Hemisphere influenza and vaccine effectiveness research and surveillance. Respiratory viruses are commonly detected in both symptomatic and asymptomatic periods. keywords: ari; aris; children; detection; study; viruses cache: cord-349279-wbb7h2zu.txt plain text: cord-349279-wbb7h2zu.txt item: #411 of 427 id: cord-349287-mwj2qby4 author: Mackay, Ian M. title: MERS coronavirus: diagnostics, epidemiology and transmission date: 2015-12-22 words: 14293 flesch: 47 summary: There are human MERS cases that do not fall into either category of source and it is unclear if these acquired infection through some entirely separate route, or from cases that escaped diagnosis. However, on occasion, even LRT specimens from MERS cases may initially be negative, only to later become positive by RT-PCR [95] . keywords: camels; cases; contact; coronavirus; cov; dcs; disease; east; hospital; human; infected; infection; ksa; mers; middle; middle east; outbreak; respiratory; rna; south; syndrome; syndrome coronavirus; transmission cache: cord-349287-mwj2qby4.txt plain text: cord-349287-mwj2qby4.txt item: #412 of 427 id: cord-349560-8n65rgfz author: Kleines, Michael title: WU Polyomavirus (WUPyV): A Recently Detected Virus Causing Respiratory Disease? date: 2009-11-04 words: 4055 flesch: 42 summary: The discovery of novel respiratory viruses has the potential to diminish the diagnostic gap for respiratory tract infections. Respiratory tract infections are a major cause of hospital admission in infants and young children. keywords: children; detection; disease; human; infections; tract; virus; wupyv cache: cord-349560-8n65rgfz.txt plain text: cord-349560-8n65rgfz.txt item: #413 of 427 id: cord-349606-lup6tm2s author: Biill Primo, Osvaldo Vinícius title: Detection of Respiratory Viruses in Nasopharyngeal Swab and Adenoid Tissue from Children Submitted to Adenoidectomy: Pre- and Postoperative Analysis date: 2014-02-17 words: 2796 flesch: 38 summary: key: cord-349606-lup6tm2s authors: Biill Primo, Osvaldo Vinícius; Lourenço, Edmir Américo; Passos, Saulo Duarte title: Detection of Respiratory Viruses in Nasopharyngeal Swab and Adenoid Tissue from Children Submitted to Adenoidectomy: Pre- and Postoperative Analysis date: 2014-02-17 journal: Int Arch Otorhinolaryngol DOI: 10.1055/s-0034-1368135 sha: doc_id: 349606 cord_uid: lup6tm2s Introduction The presence of respiratory viruses in lymphoid tissues of the nasopharynx and oropharynx and its impact on recurrent infections and hypertrophy of these tissues are not yet fully understood. Respiratory viruses were identified in 33.8% of preoperative nasopharyngeal specimens and in 19.8% of postoperative secretion. keywords: adenoid; nasopharyngeal; samples; tissue; viruses cache: cord-349606-lup6tm2s.txt plain text: cord-349606-lup6tm2s.txt item: #414 of 427 id: cord-349956-h4i2t2cr author: Hoang, Van-Thuan title: The dynamics and interactions of respiratory pathogen carriage among French pilgrims during the 2018 Hajj date: 2019-11-21 words: 4857 flesch: 41 summary: key: cord-349956-h4i2t2cr authors: Hoang, Van-Thuan; Dao, Thi-Loi; Ly, Tran Duc Anh; Belhouchat, Khadidja; Chaht, Kamel Larbi; Gaudart, Jean; Mrenda, Bakridine Mmadi; Drali, Tassadit; Yezli, Saber; Alotaibi, Badriah; Fournier, Pierre-Edouard; Raoult, Didier; Parola, Philippe; de Santi, Vincent Pommier; Gautret, Philippe title: The dynamics and interactions of respiratory pathogen carriage among French pilgrims during the 2018 Hajj date: 2019-11-21 journal: Emerg Microbes Infect DOI: 10.1080/22221751.2019.1693247 sha: doc_id: 349956 cord_uid: h4i2t2cr We conducted this study to describe the dynamics of the acquisition of respiratory pathogens, their potential interactions and risk factors for possible lower respiratory tract infection symptoms (LRTI) among French pilgrims during the 2018 Hajj. Unadjusted associations between respiratory pathogen carriage with multiples factors: sociodemographic characteristics (gender, ≥60 years), chronic respiratory disease, BMI classification, smoking status; individual preventive measures (vaccination against influenza, vaccination against IPD, use of a face mask, hand washing, disinfectant gel and disposable handkerchiefs); antibiotic intake 10 days before each sample; respiratory virus or bacteria and dual carriage were analysed by univariable analysis. keywords: aureus; carriage; catarrhalis; hajj; influenzae; pathogens; pilgrims; pneumoniae; symptoms cache: cord-349956-h4i2t2cr.txt plain text: cord-349956-h4i2t2cr.txt item: #415 of 427 id: cord-350928-vj5qlzpj author: Arnott, Alicia title: Human bocavirus amongst an all‐ages population hospitalised with acute lower respiratory infections in Cambodia date: 2012-04-25 words: 4341 flesch: 46 summary: The incidence of HBoV did not vary between the consecutive seasons investigated, and HBoV infections were detected year‐round. The incidence of HBoV infection was highest in patients aged <2 years, with pneumonia or bronchopneumonia the most common clinical diagnosis, regardless of age. keywords: bocavirus; cambodian; children; hbov; human; infection; patients; sequences; study cache: cord-350928-vj5qlzpj.txt plain text: cord-350928-vj5qlzpj.txt item: #416 of 427 id: cord-351008-p0n1fdxw author: Monge, Susana title: Ambulance dispatch calls attributable to influenza A and other common respiratory viruses in the Netherlands (2014‐2016) date: 2020-05-14 words: 3081 flesch: 37 summary: Overall, 15% of RSC were attributable to respiratory viruses (20% in out‐of‐office hour calls). Surveillance of respiratory viruses is mainly centred on influenza, for which robust systems have been developed in most countries, generally based on sentinel networks of General Practitioners (GPs, primary care). keywords: ambulance; calls; influenza; rsc; surveillance; viruses cache: cord-351008-p0n1fdxw.txt plain text: cord-351008-p0n1fdxw.txt item: #417 of 427 id: cord-351046-yq7287k9 author: Schubert, Gena title: How Much Drool Is Too Much?() date: 2019-12-13 words: 3242 flesch: 45 summary: It is estimated that the risk of myasthenic crisis in myasthenia gravis patients may be as high as 10 to 20%, and 13 to 20% of myasthenia gravis presents with myasthenic crisis as the first manifestation. Approximately 15% of patients with myasthenia gravis are found to have a thymoma. keywords: diagnosis; examination; gravis; myasthenia; normal; patient; ptosis; rate; treatment cache: cord-351046-yq7287k9.txt plain text: cord-351046-yq7287k9.txt item: #418 of 427 id: cord-351323-cbejbm5v author: Roy Mukherjee, Tapasi title: Spectrum of respiratory viruses circulating in eastern India: Prospective surveillance among patients with influenza‐like illness during 2010–2011 date: 2013-06-13 words: 3280 flesch: 34 summary: Hence the information on epidemiology and clinical features of respiratory virus infection in India is based entirely on research studies and the disease burden or seasonal prevalence of respiratory viruses remains largely undefined. During 2007-2008, only 8.7% of respiratory syncytial virus infection was found among children [Agrawal et al., 2009b] ; whereas in the same geographical region, 13.7% samples were found to be positive for respiratory syncytial virus in children (under 5 years) during this study period (2010) (2011) . keywords: acute; children; et al; infections; influenza; viruses cache: cord-351323-cbejbm5v.txt plain text: cord-351323-cbejbm5v.txt item: #419 of 427 id: cord-351990-aham72b9 author: Radin, Jennifer M. title: Epidemiology of Pathogen-Specific Respiratory Infections among Three US Populations date: 2014-12-30 words: 4514 flesch: 38 summary: This population is also highly vaccinated for influenza and showed the smallest amount of influenza infection compared with the other two populations. In our 5-24 year olds we found fever, cough, and short time to seeking care to be predictive of influenza infection. keywords: age; fever; infections; influenza; pathogen; populations; rhinovirus; study cache: cord-351990-aham72b9.txt plain text: cord-351990-aham72b9.txt item: #420 of 427 id: cord-352222-zq9o66i4 author: Rajatonirina, Soatiana title: Outcome Risk Factors during Respiratory Infections in a Paediatric Ward in Antananarivo, Madagascar 2010–2012 date: 2013-09-12 words: 4140 flesch: 44 summary: We conducted a prospective study in a paediatric ward in Antananarivo from November 2010 to July 2012 including patients under 5 years old suffering from respiratory infections. Respiratory infections are a major cause of infectious diseaserelated morbidity, hospitalisation, and mortality among children under 5 years old worldwide, and particularly in developing countries [1] . keywords: children; hospitalisation; infections; influenza; months; patients; pneumonia; study cache: cord-352222-zq9o66i4.txt plain text: cord-352222-zq9o66i4.txt item: #421 of 427 id: cord-352684-4o623x3n author: Tan, M. Y. title: Bocavirus infection following paediatric liver transplantation date: 2016-10-23 words: 1630 flesch: 45 summary: We report HBoV infection in a child post‐liver transplantation, who presented with persistent fever and mild tachypnea, 3 weeks after a successful transplant. There are a few reports of HBoV infections in immunocompromised hosts wherein they have caused respiratory or diarrhoeal illness, and rarely even life-threatening conditions in the stem cell transplant population. keywords: fever; hbov; infection; transplant cache: cord-352684-4o623x3n.txt plain text: cord-352684-4o623x3n.txt item: #422 of 427 id: cord-352837-a29d5dkv author: Hirsch, Hans H title: Spatiotemporal Virus Surveillance for Severe Acute Respiratory Infections in Resource-limited Settings: How Deep Need We Go? date: 2019-04-01 words: 1999 flesch: 22 summary: Redefining chronic viral infection Translational aspects of the human respiratory virome A new arenavirus in a cluster of fatal transplant-associated diseases Identification of a novel polyomavirus in a pancreatic transplant recipient with retinal blindness and vasculitic myopathy The human gut virome: inter-individual variation and dynamic response to diet Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation Temporal response of the human virome to immunosuppression and antiviral therapy Full-length haplotype reconstruction to infer the structure of heterogeneous virus populations Evaluation of unbiased next-generation sequencing of RNA (RNA-seq) as a diagnostic method in influenza virus-positive respiratory samples Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis Mortality associated with influenza and respiratory syncytial virus in the United States Global mortality estimates for the 2009 influenza pandemic from the GLaMOR project: a modeling study Comparing viral respiratory tract infections in symptomatic children and adults: multiplex NAT from 2010-2015 Comparing Luminex NxTAG-respiratory pathogen panel and RespiFinder-22 for multiplex detection of respiratory pathogens Community-acquired respiratory paramyxovirus infection after allogeneic hematopoietic cell transplantation: a single-center experience Comprehensive diagnostics for respiratory virus infections after transplantation or after potential exposure to swine flu A/H1N1: what else is out there? High incidence of active cytomegalovirus infection among septic patients Sepsis and cytomegalovirus: foes or conspirators? Viral impact on long-term kidney graft function Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments BK virus: opportunity makes a pathogen Reactivation of multiple viruses in patients with sepsis Torque teno virus in children who underwent orthotopic liver transplantation: new insights about a common pathogen Viral infection in acute exacerbation of idiopathic pulmonary fibrosis The evolution of seasonal influenza viruses Taken together, this report from resource-limiting settings is also of relevance for resource-rich countries and raises the question about how to best expand current first-or second-line testing for respiratory viral pathogens including CMV, parvovirus B19, and measles, and how to move to more deep sequencing virome analysis and comprehensive metagenomics in the near future. keywords: cases; human; respiratory; sari; sequencing; virus cache: cord-352837-a29d5dkv.txt plain text: cord-352837-a29d5dkv.txt item: #423 of 427 id: cord-353308-e4s8el0s author: Parashar, Umesh D title: Severe acute respiratory syndrome: review and lessons of the 2003 outbreak date: 2004-05-20 words: 4501 flesch: 37 summary: A multicentre collaboration to investigate the cause of severe acute respiratory syndrome Coronavirus as a possible cause of severe acute respiratory syndrome Identification of a novel coronavirus in patients with severe acute respiratory syndrome A novel coronavirus associated with severe acute respiratory syndrome Update 96-Taiwan, China: SARS transmission interrupted in last outbreak area Koch's postulates fulfilled for SARS virus Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome The genome sequence of the SARS-associated coronavirus Characterization of a novel coronavirus associated with severe acute respiratory syndrome Role of China in the quest to define and control severe acute respiratory syndrome Prevalence of IgG antibody to SARS-associated coronavirus in animal traders-Guangdong province Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China SARS virus infection of cats and ferrets SARS-related virus predating SARS outbreak, Hong Kong. 26 Pathological findings in the lungs of SARS patients during the first 10 days of illness include pneumocyte proliferation and desquamation, hyaline membrane formation, mixed inflammatory infiltrate, and intra-alveolar oedema. keywords: cases; coronavirus; cov; health; illness; outbreak; patients; sars; syndrome; transmission cache: cord-353308-e4s8el0s.txt plain text: cord-353308-e4s8el0s.txt item: #424 of 427 id: cord-353698-gj8sx3zy author: Bibiano-Guillen, C. title: Adapted Diving Mask (ADM) device as respiratory support with oxygen output during COVID-19 pandemic date: 2020-10-28 words: 3323 flesch: 47 summary: This prevents exposure to other patients and healthcare professionals [29, 32, 33] . To assess patient improvement, we used the following variables: The medical records of patients were analyzed by the research team of the Emergency Department, Hospital Universitario Infanta Leonor, Madrid. keywords: adm; covid-19; mask; oxygen; patients; saturation; support; use cache: cord-353698-gj8sx3zy.txt plain text: cord-353698-gj8sx3zy.txt item: #425 of 427 id: cord-353786-284qn075 author: Chen, Zhi-Min title: Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus date: 2020-02-05 words: 3552 flesch: 43 summary: Following latest National recommendations for diagnosis and treatment of respiratory infections caused by 2019-nCoV (the 4th edition) and current status of clinical practice in Zhejiang Province, recommendations for the diagnosis and treatment of respiratory infection caused by 2019-nCoV for children were drafted out by the National Clinical Research Center for Child Health, National Children's Regional Medical Center, Children's Hospital, Zhejiang University School of Medicine to further standardize the protocol of respiratory infection in children caused by 2019-nCoV. Etiology 2019-nCoV is a novel human coronavirus in addition to coronavirus 229E, NL63, OC43, HKU1, Middle East respiratory syndrome-related coronavirus (MERSr-CoV) and severe acute respiratory syndrome-related coronavirus (SARS-CoV). Access 29 Clinical features of patients infected with 2019 novel coronavirus in Wuhan Another decade, another coronavirus Diangosis and treatment guideline of community acquired pneumonia in children Role of Lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Treatment of Middle East respiratory syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial Expert consensus on the diagnosis and treatment of viral pneumonia in children Corticosteroid therapy for critically ill patients with Middle East respiratory syndrome Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected The Editorial Board, Chinese Journal of Pediatrics. keywords: blood; cases; children; coronavirus; diagnosis; infection; ncov; patients; pneumonia; treatment cache: cord-353786-284qn075.txt plain text: cord-353786-284qn075.txt item: #426 of 427 id: cord-354918-129inbwq author: Kotsimbos, T. title: Respiratory infectious disease: complacency with empiricism in the age of molecular science. We can do better! date: 2007-06-04 words: 2102 flesch: 23 summary: This information could aid decision-making in terms of whether to use prophylactic or pre-emptive antibiotics to avoid specific acute infection syndromes in certain 'at-risk' patient groups, a strategy already used in HIV/AIDS. All the issues related to acute respiratory infections in otherwise-healthy individuals apply to an even greater degree to 'at-risk' groups. keywords: disease; management; respiratory; rid; risk cache: cord-354918-129inbwq.txt plain text: cord-354918-129inbwq.txt item: #427 of 427 id: cord-355165-xc6ythgp author: van den Wijngaard, Cees title: Validation of Syndromic Surveillance for Respiratory Pathogen Activity date: 2008-06-17 words: 4565 flesch: 35 summary: Negative associations (e.g., between enteroviruses, which peak in summer, vs. respiratory syndromes, which peak in winter) were excluded to avoid noncausal effects. To discriminate between primary and secondary infections by S. pneumoniae (as a complication of respiratory virus infection) (16) (17) (18) (19) , we used the residuals from regressing S. pneumoniae counts on other pathogens as the variable for S. pneumoniae (instead of its counts) for all the earlier described models for respiratory syndromes. keywords: absenteeism; counts; data; infl; laboratory; pathogen; surveillance; syndrome; uenza cache: cord-355165-xc6ythgp.txt plain text: cord-355165-xc6ythgp.txt