item: #1 of 47
          id: cord-000799-s70onyix
      author: Wang, Ting
       title: Particulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation
        date: 2012-08-29
       words: 5899
      flesch: 41
     summary: These data represent the first evidence that calpain signaling, via calcium leakage from activated TRPM2 by ROS, plays a critical role in modulating endothelial cell barrier function, resulting in tight junction protein ZO-1 degradation (Additional file 1 Figure S7 ). key: cord-000799-s70onyix authors: Wang, Ting; Wang, Lichun; Moreno-Vinasco, Liliana; Lang, Gabriel D; Siegler, Jessica H; Mathew, Biji; Usatyuk, Peter V; Samet, Jonathan M; Geyh, Alison S; Breysse, Patrick N; Natarajan, Viswanathan; Garcia, Joe G N title: Particulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation date: 2012-08-29 journal:
    keywords: barrier; calpain; ecs; endothelial; figure; lung; protein; ros; trpm2; zo-1
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        item: #2 of 47
          id: cord-001347-ssrs0cwf
      author: Michaelis, Martin
       title: Effects of flavonoid-induced oxidative stress on anti-H5N1 influenza a virus activity exerted by baicalein and biochanin A
        date: 2014-06-23
       words: 2013
      flesch: 35
     summary: Highly pathogenic influenza A viruses including H5N1 viruses represent a major pandemic threat. [28] that are known to be involved in influenza virus replication such as AKT, ERK 1/2, and NFκB [10, [29]
    keywords: baicalein; biochanin; cells; h5n1; influenza; virus
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        item: #3 of 47
          id: cord-001769-2sdg5ll7
      author: Guo, Sheng
       title: The NLRP3 Inflammasome and IL-1β Accelerate Immunologically Mediated Pathology in Experimental Viral Fulminant Hepatitis
        date: 2015-09-14
       words: 6553
      flesch: 35
     summary: Therefore, in response to MHV-3 viral infection, IL-1R1 -/mice responded with limited fibrinogen formation, leading to a down modulation of liver coagulation and necrosis ( Fig 3D) . Silica crystals, LPS, and uric acid crystals act as the stimulators in these studies, while MHV-3 virus is the activator in our research.
    keywords: activation; cells; expression; fgl2; fig; il-1β; infection; inflammasome; liver; mice; nlrp3; ros; viral; virus
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        item: #4 of 47
          id: cord-003841-7uaj9hmx
      author: Desmonts de Lamache, D.
       title: Immuno-modulating properties of Tulathromycin in porcine monocyte-derived macrophages infected with porcine reproductive and respiratory syndrome virus
        date: 2019-08-23
       words: 8002
      flesch: 34
     summary: Treatment with tulathromycin (1mg/mL) significantly reduced PRRSV cell necrosis at 12 hours (Fig 9) . However, due to its high antigenic variability and poorly understood immunopathogenesis, there is currently no effective vaccine or treatment to control PRRSV infection.
    keywords: anti; cells; effects; fig; infection; l929; macrophages; mdms; monocyte; porcine; production; prrsv; syndrome; tulathromycin; usa; virus
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        item: #5 of 47
          id: cord-004508-ok3px98z
      author: Armando, Federico
       title: Oxidative Stress in Canine Histiocytic Sarcoma Cells Induced by an Infection with Canine Distemper Virus Led to a Dysregulation of HIF-1α Downstream Pathway Resulting in a Reduced Expression of VEGF-B In Vitro
        date: 2020-02-11
       words: 8287
      flesch: 30
     summary: Five formalin-fixed paraffin embedded (FFPE) cell pellets of non-infected DH82 cells and 5 of DH82Ond pi cells were produced as previously described [43] . For CDV-NP, 8OHdG, SOD2, CAT, HIF-1α, and VEGF-B, the percentage of immunopositive cells for each group (non-infected DH82 cells and DH82Ond pi cells) was assessed manually by counting 5 evenly distributed fields per pellet at a 400x magnification using an inverted fluorescence microscope (Olympus IX-70, Olympus Optical Co. GmbH, Hamburg, Germany) equipped with a Olympus DP72 camera and Olympus cellSens standard software version 2.3.
    keywords: canine; cdv; cells; dh82 cells; dh82ond; dh82ond pi; expression; hif-1α; median; non; pi cells; range; ros; stress; virus
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        item: #6 of 47
          id: cord-005280-a23oy0sz
      author: Yang, Shenshu
       title: ROS and diseases: role in metabolism and energy supply
        date: 2019-12-07
       words: 5908
      flesch: 36
     summary: Hypoxia inducible factor-2 alpha (HIF-2α ) encoded by endothelial PAS domain protein 1 (Epas1) gene could control ROS level in mitochondria through antioxidant enzymes and maintain ROS homeostasis ROS level also could be controlled through degradation of NOX2 on endoplasmic reticulum by protein negative regulator of ROS (NRROS).
    keywords: apoptosis; cancer; cells; damage; energy; generation; level; metabolism; mitochondrial; oxygen; production; role; ros; species
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        item: #7 of 47
          id: cord-006230-xta38e7j
      author: None
       title: Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e.V.
        date: 2012-02-22
       words: 136000
      flesch: 40
     summary: In in-vitro studies on rat and canine mast cells and human mast cell leukemia cells HMC1.2 BZ at micromolar concentrations inhibited mediator release which appeared to be related to an inhibition of the intracellular cAMP pathway. Previous work showed that mouse cells lacking the immediate-early gene c-fos are hypersensitive to ultraviolet (UVC) light.
    keywords: acid; activation; activity; acute; addition; adducts; agonist; aim; analysis; animals; anti; apoptosis; approach; assay; assessment; binding; blood; brain; calcium; camp; cancer; cancer cells; cardiac; cell line; cells; cellular; cgmp; changes; channels; chronic; clinical; complex; compounds; concentration; conclusion; conditions; contrast; control; current; damage; data; days; death; decrease; deficient; development; differences; differentiation; disease; dna; dose; drug; e.g.; effects; endothelial; enzyme; evidence; experiments; exposure; expression; factor; failure; family; fibroblasts; findings; fold; food; formation; function; für; g protein; gene; gene expression; germany; glucose; growth; health; heart; human; hypertrophy; increase; induction; inflammation; inhibition; inhibitors; institut; insulin; interaction; intracellular; kidney; kinase; leads; levels; like; line; liver; loss; low; lung; macrophages; mechanisms; membrane; methods; mice; model; mouse; mrna; muscle cells; mutations; nanoparticles; ndpk; non; novel; number; pain; pathway; patients; pcr; pharmakologie; phosphorylation; plasma; potential; presence; present; pressure; primary; processes; production; products; proliferation; promoter; properties; protein; protein expression; pulmonary; rats; receptor; reduced; regulation; release; response; results; risk; rkip; role; ros; samples; selective; signaling; site; skin; smooth; specific; stimulation; stress; studies; study; substances; subunits; synthesis; system; t cells; target; test; tested; therapy; time; tissue; toxicity; toxikologie; toxin; transcription; transport; treatment; tumor; tumor cells; type; universität; uptake; values; vascular; vitro; vivo; water
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        item: #8 of 47
          id: cord-012495-r6nkdeaw
      author: Bonora, Massimo
       title: Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology
        date: 2020-07-04
       words: 11979
      flesch: 26
     summary: Wang et al. proposed that the overexpression of mitochondrial hepatic CypD induced mitochondrial stress and could be an early event that leads to the liver steatosis [186] . Although mitochondrial diseases can involve any organ or tissue, they characteristically involve multiple systems, typically affect organs that are highly dependent on aerobic metabolism and are often relentlessly progressive with high morbidity and mortality.
    keywords: activation; apoptosis; atp; cell; csa; cypd; death; disease; injury; ischemia; mice; mitochondria; model; mpt; opening; permeability; permeability transition; pore; protein; ptpc; reperfusion; ros; synthase; transition
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        item: #9 of 47
          id: cord-013415-110b95cg
      author: Aquino-Martinez, Ruben
       title: Periodontal Disease and Senescent Cells: New Players for an Old Oral Health Problem?
        date: 2020-10-09
       words: 10338
      flesch: 23
     summary: For this reason, many researchers have used various genotoxic agents to accelerate cell senescence. key: cord-013415-110b95cg authors: Aquino-Martinez, Ruben; Khosla, Sundeep; Farr, Joshua N.; Monroe, David G. title: Periodontal Disease and Senescent Cells: New Players for an Old Oral Health Problem? date: 2020-10-09 journal: Int J Mol Sci DOI: 10.3390/ijms21207441 sha: doc_id: 13415 cord_uid: 110b95cg The recent identification of senescent cells in periodontal tissues has the potential to provide new insights into the underlying mechanisms of periodontal disease etiology.
    keywords: bacteria; cells; damage; dna; dna damage; factors; gingival; human; immune; inflammation; oxidative; senescence; senescent cells; stress; tissue
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        item: #10 of 47
          id: cord-014661-mrh2pbi6
      author: Dumitrascu, Georgiana R.
       title: Critical physiological and pathological functions of Forkhead Box O tumor suppressors
        date: 2013-12-31
       words: 9254
      flesch: 30
     summary: The advances in understating the mechanism of FOXOs regulation of stem cells, cancer stem cells and how non-coding RNAs are regulated and regulate the function of FOXO genes/protein are presented. Similarities between stem cells and cancer stem cells were best described in the hematopoietic system, where similar surface markes and signal transduction patterns were described between the hematopoietic stem cells and leukemia-initiating cells 121 .
    keywords: activation; akt; apoptosis; cancer; cell; cycle; dna; expression; factors; family; forkhead; foxo; foxo proteins; foxo transcription; genes; proliferation; proteins; role; stem; transcription
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        item: #11 of 47
          id: cord-017817-ztp7w9yh
      author: Land, Walter Gottlieb
       title: Cell-Autonomous (Cell-Intrinsic) Stress Responses
        date: 2018-03-28
       words: 17769
      flesch: 34
     summary: A typical example is represented by oxidative stress and ER stress responses, which appear to act mutually in any form of cellular damage. ATF activating transcription factor, CHOP cytidine-cytidine-adenosine-adenosine thymidine-enhancer-binding homologous protein, eIF2α eukaryotic translational initiation factor 2α, ER endoplasmic reticulum, IRE1α inositol-requiring transmembrane kinase/endoribonuclease 1α, PERK protein kinase-like eukaryotic initiation factor 2α kinase, UPR unfolded protein response, XBP1 X-box binding protein 1. XBP1s, X-box binding protein 1 whereby the s stands for the spliced form of XBP1.
    keywords: autophagy; cell; complex; damage; damps; degradation; dna; example; heat; immune; innate; keap1; mechanisms; membrane; nrf2; oxidative; pathway; process; protein; regulation; response; role; ros; signalling; stress; stress response; transcription; upr
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        item: #12 of 47
          id: cord-020646-s7eopu9y
      author: None
       title: Die Pathophysiologie der Entzündung
        date: 2005
       words: 30238
      flesch: 48
     summary: Die bei der Hydrolyse von ATP frei werdende Energie wird in Bewegung entlang dem Aktinfaden vom Minus-zum Plus-Ende umgesetzt. Die Hauptvertreter der FGF-Familie sind der acidic fi broblast growth factor (aFGF) und der basic fi broblast growth factor (bFGF).
    keywords: abb; abbau; aber; abgabe; abgegeben; abwehr; adhäsine; aktin; aktiviert; aktivierung; aktivität; allem; als; andere; app; auch; auf; aus; aus der; bedeutung; bei; bei der; beim; bereich; bereits; besonders; besteht; bewirkt; bezeichnet; bilden; bildung; bis; blut; blutbahn; blutgerinnung; blutzellen; chemotaxis; cox; csf; cytokine; dabei; dadurch; dagegen; daher; damit; dar; darüber; das; dass; dazu; dem; den; der; der entzündung; der pmn; deren; des; die; diese; drei; durch; durch den; durch die; durch eine; eine; eingesetzt; ende; endothelzellen; entstehen; entzündliche; entzündung; entzündungsherd; enzyme; epa; erfolgt; erhöht; erreicht; erster; etwa; fettsäuren; fibroblasten; fieber; folge; form; freigesetzt; freisetzung; führen; führt; für; für die; gang; gegenüber; gewebe; glucocorticoide; granula; granulozyten; gut; hat; hemmung; hier; hinaus; histamin; häufi; ige; ihre; indem; ins; intrazellulären; ist; ist das; ist der; ist die; ist ein; jedoch; kann; komplex; kontraktion; konzentration; können; linie; lymphozyten; makrophagen; man; manche; mastzellen; mediatoren; mehr; migration; mikrotubuli; mit; mit der; muss; myosin; nach; ndet; neben; nicht; noch; nsaid; nur; oberfl; oder; organismus; paf; pge2; phagozyten; phagozytose; pmn; produktion; proteine; rahmen; reaktionen; reichlich; reihe; rezeptoren; richtung; rolle; ros; schen; schmerz; sehr; sein; serotonin; setzen; sich; sie; sind; solche; sondern; sowie; spezifi; stark; stellen; stimuliert; strukturen; synthese; teil; therapie; thrombozyten; tnfα; treten; typ; umgebung; und; und bei; und das; und der; und eine; und ist; unspezifi; unter; uss; verschiedenen; vom; von; von der; von pmn; vor; weg; wegen; weise; weiter; welche; wenn; werden; wesentlich; wie; wiederum; wird; wird der; wirken; wirkstoffe; wirkung; wirkungen; wobei; wurde; während; z.b; zahl; zellen; zellmembran; zelltypen; zentrum; zu den; zum; zur; zusammen; zwei; zwischen; äche; ödem; über; über den; über die; über eine
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        item: #13 of 47
          id: cord-022940-atbjwpo5
      author: None
       title: Poster Sessions
        date: 2016-09-07
       words: 241687
      flesch: 44
     summary: Among used cancer cell lines, ERICD was highly expressed and ARID3A had lower expression in U-2OS (osteosarcoma), A-172 (glioblastoma) and A549 (lung cancer). Clear cell renal cell cancer (ccRCC) with metastases has pour prognosis: 5-year survival is about 9%.
    keywords: a549 cells; acid; activation; activities; activity; activity levels; acute; addition; administration; affinity; agents; aim; albumin; allele; alterations; alternative; amino; analysis; analysis results; animals; ankara; anti; antibodies; antibody; anticancer; antioxidant; apoptosis; applications; approach; assay; association; bacteria; beta; binding; biology; blood; body; bone; brain; breast cancer; cancer cells; cancer group; cancer patients; cancer stem; cancer treatment; cancers; cause; cell cycle; cell death; cell growth; cell lines; cell proliferation; cell survival; cell viability; changes; characterization; chemical; cholesterol; chronic; clinical; coli; colorectal; combination; comparison; complex; complexes; compounds; concentrations; conclusion; conditions; content; control cells; control group; control study; controls; correlation; culture; curcumin; current; cytotoxic; damage; data; day; days; decrease; department; detection; determination; development; diabetes; differences; differentiation; discussion; disease; dna; domain; dose; drug; effects; elevated; elisa; energy; enzyme; enzyme activity; ethanol; experimental; expression analysis; expression levels; expressions; extract; factor; faculty; family; fat; findings; flow; fluorescence; fold; food; formation; free; function; gene expression; genes; genetic; genome; genotype; glucose; glutathione; group; growth; gsh; health; hours; human; immune; increase; inflammation; inflammatory; inhibition; inhibitors; injury; institute; insulin; interaction; intracellular; introduction; invasion; investigation; ischemia; kinase; laboratory; lead; levels; light; like; lipid; liver; low; lung; male; manner; markers; mass; materials; matrix; mcf-7; mda; mda levels; mean; mechanisms; medical; medicine; medium; membrane; metabolism; methods; methylation; mice; microscopy; migration; mirnas; mitochondrial; model; modified; molecular; molecules; mrna; muscle; mutant; mutations; n =; nanoparticles; negative; non; normal; novel; number; obese; obesity; oil; order; oxidative; oxygen; p =; p-02.08.5; parameters; pathway; patients; pcr; peptide; phase; plant; plasma; play; point; polymorphisms; population; potential; presence; present; process; processes; production; products; profile; progression; promoter; properties; prostate; prostate cancer; protective; protein; protein expression; protein levels; purpose; radical; range; rate; rats; reaction; receptor; recombinant; region; regulation; related; relationship; research; resistance; response; results; risk; role; samples; science; scientific; screening; sequence; serum; serum levels; signaling; site; size; sod; species; specific; stability; stage; status; stem cells; strain; stress; structure; studies; study; study group; subjects; surface; survival; synthesis; system; target; technique; temperature; test; tested; therapeutic; therapy; time; tissue; tnf; total; transcription; treatment; treatment group; tumor; tumor cells; turkey; type; university; use; values; vitamin; vitro; water; weight; western; wild; women; work; years
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        item: #14 of 47
          id: cord-032561-x3qbqy69
      author: Liu, Gengqi
       title: Stimulus-Responsive Nanomedicines for Disease Diagnosis and Treatment
        date: 2020-09-02
       words: 25271
      flesch: 43
     summary: In the microenvironment of the diseased sites, the levels of some enzymes can be abnormal; therefore, enzyme-responsive systems represent an appealing strategy for the development of responsive drug carriers. In the microenvironment of the diseased sites, the levels of some enzymes can be abnormal; therefore, enzyme-responsive systems represent an appealing strategy for the development of responsive drug carriers.
    keywords: addition; bond; cancer; cells; delivery; design; disulfide; drug; drug delivery; drug release; enzyme; ester; group; gsh; imaging; light; nanoparticles; nir; redox; release; self; stimuli; stimulus; systems; therapy; tissues; treatment; tumor; ultrasound
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        item: #15 of 47
          id: cord-034294-ti1cc24m
      author: Wang, Cuixue
       title: Progress in the mechanism and targeted drug therapy for COPD
        date: 2020-10-27
       words: 16542
      flesch: 29
     summary: COPD patients suffer from oxidative stress caused by the inhalation of cigarette smoke (CS) or harmful substances which causes an accumulation of pulmonary inflammatory cells (neutrophils, macrophages), leading to large numbers of reactive oxygen species (ROS). 221 Clinically, they are used for long-term treatment of chronic inflammatory lung diseases such as COPD.
    keywords: activation; airway; akt; anti; cells; chronic; copd; copd patients; development; disease; effects; expression; factor; growth; inflammation; inhibitors; kinase; lung; neutrophils; oxidative; pathway; patients; pi3k; production; protein; pulmonary; receptor; regulating; role; signalling; stress; tgf; trx
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        item: #16 of 47
          id: cord-034321-ohjik0pf
      author: Vorobjeva, N. V.
       title: NETosis: Molecular Mechanisms, Role in Physiology and Pathology
        date: 2020-10-27
       words: 7606
      flesch: 38
     summary: The mitochondrial permeability transition pore: channel formation by F ATP synthase, integration in signal trans duction, and role in pathophysiology Effect of transient and perma nent permeability transition pore opening on NAD(P)H localization in intact cells The mitochondrial death/life regulator in apoptosis and necrosis A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis Mitochondrial non specific pores remain closed during cardiac ischaemia, but open upon reperfusion A myeloperoxidase containing complex regulates neutrophil elastase release and actin dynamics during NETosis Neutrophil elastase and myeloperoxi dase regulate the formation of neutrophil extracellular traps Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity Lysosomal membrane permeabilization in cell death: con cepts and challenges, Mitochondrion is essential for antibacterial innate immunity mediated by neutrophil extracellular traps Regulation of extracellular chromatin release from neu trophils Cell cycle proteins control production of neutrophil extracellular traps Gasdermin D exerts anti inflammatory effects by promoting neutrophil death Gasdermin D plays a vital role in the generation of neutrophil extracellular traps Noncanonical inflamma some signaling elicits gasdermin D dependent neutrophil extracellular traps Cleavage of DFNA5 by caspase 3 during apoptosis mediates progres sion to secondary necrotic/pyroptotic cell death Gasdermin pores permeabilize mitochondria to augment caspase 3 activation during apoptosis and inflammasome activation Ménage à Trois: the ratio of bicar bonate to CO2 and the pH regulate the capacity of neu trophils to form NETs Alkaline pH promotes NADPH oxi dase independent neutrophil extracellular trap formation: a matter of mitochondrial reactive oxygen species genera tion and citrullination and cleavage of histone Extracellular acidification inhibits the ROS dependent formation of neutrophil extracellular traps The impact of hypoxia on neutrophil degranula tion and consequences for the host Formation of neutrophil extracellular traps under low oxy gen level Hypertonic saline suppresses NADPH BIOCHEMISTRY oxidase dependent neutrophil extracellular trap formation and promotes apoptosis Inhibition of neutrophil extracellular trap formation after stem cell transplant by prostaglandin E2 Prostaglandin E2 inhibits neutrophil extracellular trap formation through production of cyclic AMP Activated protein C inhibits neutrophil extracellular trap formation in vitro and activa tion in vivo Neutrophil extracellular traps mediate a host defense response to human immunodefi ciency virus 1 Neonatal NET inhibitory factor and related peptides inhibit neutrophil extracellular trap formation Modulation of neutrophil NETosis: inter play between infectious agents and underlying host physiolo gy Hepatitis B virus inhibits neu trophil extracellular trap release by modulating reactive oxygen species production and autophagy Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on cell death Platelet TLR4 activates neu trophil extracellular traps to ensnare bacteria in septic blood Infection induced NETosis is a dynamic process involving neutrophil multitasking in vivo Catapult like release of mitochondrial DNA by eosinophils contributes to antibacterial defense Viable neutrophils release mitochon drial DNA to form neutrophil extracellular traps Lymphocytes eject interferogenic mitochondrial DNA webs in response to CpG and non CpG oligodeoxynucleotides of class C Neutrophil extracellular traps involvement in corneal fungal infection Distinct susceptibilities of corneal Pseudomonas aeruginosa clin ical isolates to neutrophil extracellular trap mediated immuni ty Ocular surface extracellular DNA and nuclease activity imbalance: a new paradigm for inflammation in dry eye disease Hyper osmolar stress induces neutrophil extracellular trap forma tion: implications for dry eye disease Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft vs. host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies Autoantibodies to neutrophil extracellular traps represent a potential serological biomarker in rheumatoid arthritis Results of a multicenter, randomized, double masked, placebo con trolled clinical study of the efficacy and safety of visomitin eye drops in patients with dry eye syndrome Thrombosis: tangled up in NETs The pathway of neutrophil extracellular traps towards atherosclerosis and thrombosis Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice Platelet neu trophil interplay: insights into neutrophil extracellular trap (NET) driven coagulation in infection Thrombus NET content is associated with clinical outcome in stroke and myocardial infarction Inflammation. Rapid killing of human neutrophils by the potent activator phorbol 12 myristate 13 acetate (PMA) accompa nied by changes different from typical apoptosis or necrosis Neutrophil extracellular traps kill bacteria Unconventional roles of the NADPH oxidase: signaling, ion homeostasis, and cell death Neutrophil extracellular traps: mechanisms of formation and role in health and disease Neutrophil extracellular trap formation: physiology In vivo evidence for extracellular DNA trap formation Neutrophil extracellular traps and micro crystals Neutrophil extracellular traps and their role in the develop ment of chronic inflammation and autoimmunity Neutrophil extracellular trap cell death requires both autophagy and superoxide generation Neither eosinophils nor neutrophils require ATG5 dependent autophagy for extracellular DNA trap formation PMA and crystal induced neutrophil extra cellular trap formation involves RIPK1 RIPK3 MLKL signaling Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoim mune vasculitis
    keywords: activation; cells; chromatin; dependent; extracellular; formation; mptp; mtros; nadph; netosis; nets; neutrophil; oxidase; release; role; ros; traps
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        item: #17 of 47
          id: cord-035015-slgywe0c
      author: Nunn, Alistair V. W.
       title: SARS-CoV-2 and mitochondrial health: implications of lifestyle and ageing
        date: 2020-11-09
       words: 14677
      flesch: 27
     summary: Critically, it modulates mitochondrial function, having diverse affects depending on the tissue; it can stimulate muscle mitochondrial function [241] , but may also enhance lipid storage and adipogenesis [242] . As the immune system itself is heavily reliant on mitochondrial function, then maintaining a healthy mitochondrial system may play a key role in resisting the virus, both directly, and indirectly by ensuring a good vaccine response.
    keywords: ace2; age; anti; cell; cov-2; covid-19; data; exercise; function; health; immune; inflammasome; inflammation; key; metabolic; mitochondrial; oxidative; patients; response; role; ros; sars; stress; system; virus
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        item: #18 of 47
          id: cord-048478-ftlb5b95
      author: Mroczek, Seweryn
       title: Apoptotic signals induce specific degradation of ribosomal RNA in yeast
        date: 2008-04-01
       words: 9819
      flesch: 35
     summary: Nevertheless, a similar approach had been used to demonstrate that DNA damage in apoptotic yeast cells was an enzymatic process (30) . Cytochrome c release and mitochondria involvement in programmed cell death induced by acetic acid in Saccharomyces cerevisiae Production of reactive oxygen species and loss of viability in yeast mitochondrial mutants: protective effect of Bcl-xL Application of inhibitors and uncouplers for a study of oxidative phosphorylation Effects of the inhibitors azide, dicyclohexylcarbodiimide, and aurovertin on nucleotide binding to the three F1-ATPase catalytic sites measured using specific tryptophan probes The mitochondrial F0F1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells Translational control in stress and apoptosis Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress Ribosome inactivating proteins and apoptosis Rearrangement of nuclear ribonucleoprotein (RNP)-containing structures during apoptosis and transcriptional arrest Lsm proteins are required for normal processing and stability of ribosomal RNAs Yeast programmed cell death: an intricate puzzle The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response Role of mitochondria in the pheromone-and amiodarone-induced programmed death of yeast Saccharomyces cerevisiae has distinct adaptive responses to both hydrogen peroxide and menadione Mitochondrial function is required for resistance to oxidative stress in the yeast Saccharomyces cerevisiae The role of respiration, reactive oxygen species and oxidative stress in mother cell-specific ageing of yeast strains defective in the RAS signalling pathway Starvation for an essential amino acid induces apoptosis and oxidative stress in yeast Cells depleted of mitochondrial DNA (rho0) yield insight into physiological mechanisms Physiological regulation of yeast cell death in multicellular colonies is triggered by ammonia Defects in N-glycosylation induce apoptosis in yeast
    keywords: 25s; acid; apoptosis; apoptotic; cells; cleavage; death; degradation; dna; figure; response; ros; rrna; specific; stress; yeast
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        item: #19 of 47
          id: cord-102808-c7ajfvt5
      author: Sundqvist, Martina
       title: Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis
        date: 2020-05-01
       words: 5751
      flesch: 27
     summary: In summary, we show that Barbadin, similarly to latrunculin A, not only potentiates the ROS production induced by the different FPR2 agonists, but also resensitizes FPR2 signaling when added to FPR2 desensitized neutrophils. Collectively, these results suggest that Barbadin primes neutrophils in their response to FPR2 agonists, and the increased NADPH-oxidase activation is regulated independently of FPR2 internalization and FPR2-induced -arrestin recruitment.
    keywords: actin; agonist; ap2; barbadin; effect; fig; fpr2; neutrophils; production; receptor; ros
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        item: #20 of 47
          id: cord-257514-gw9xnb4x
      author: Yang, Mengling
       title: Hydrogen: A Novel Option in Human Disease Treatment
        date: 2020-09-05
       words: 10464
      flesch: 28
     summary: DSM 2243 T Therapeutic roles of carbon monoxide in intestinal ischemia-reperfusion injury MicroRNA files in the prevention of intestinal ischemia/reperfusion injury by hydrogen rich saline The effects of hydrogenrich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats Luminal injection of hydrogen-rich solution attenuates intestinal ischemia-reperfusion injury in rats The effects of hydrogen-rich saline solution on intestinal anastomosis performed after intestinal ischemia reperfusion injury Effects of molecular hydrogen-dissolved alkaline electrolyzed water on intestinal environment in mice Hydrogen-rich saline regulates intestinal barrier dysfunction, dysbiosis, and bacterial translocation in a murine model of sepsis Hydrogen gas protects against intestinal injury in wild type but not NRF2 knockout mice 15 Oxidative Medicine and Cellular Longevity with severe sepsis by regulating HO-1 and HMGB1 release Hydrogen gas restores exhausted CD8 + T cells in patients with advanced colorectal cancer to improve prognosis Hydrogen metabolism inHelicobacter pyloriPlays a role in gastric carcinogenesis through facilitating CagA translocation The protective of hydrogen on stress-induced gastric ulceration Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen: a new biological vision Hydrogen-rich saline attenuates acute hepatic injury in acute necrotizing pancreatitis by inhibiting inflammation and apoptosis, involving JNK and p38 mitogen-activated protein kinase-dependent reactive oxygen species Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway Effects of hydrogen gas inhalation on endometriosis in rats Protective effect of hydrogen rich saline solution on experimental ovarian ischemia reperfusion model in rats Hydrogenrich saline attenuates chemotherapy-induced ovarian injury via regulation of oxidative stress Hydrogen-rich water exerting a protective effect on ovarian reserve function in a mouse model of immune premature ovarian failure induced by zona pellucida 3 Hydrogen-rich saline attenuates spinal cord hemisection-induced testicular injury in rats Protection by hydrogen against gamma ray-induced testicular damage in rats Combination of Korean red ginseng extract and hydrogenrich water improves spermatogenesis and sperm motility in male mice Molecular hydrogen may enhance the production of testosterone hormone in male infertility through hormone signal modulation and redox balance Protective effects of hydrogen against low-dose long-term radiation-induced damage to the behavioral performances, hematopoietic system, genital system, and splenic lymphocytes in mice Saturated hydrogen alleviates CCl4-induced acute kidney injury via JAK2/STAT3/p65 signaling Aerosol inhalation of a hydrogen-rich solution restored septic renal function Hydrogen-rich saline alleviates kidney fibrosis following AKI and retains klotho expression Hydrogen-rich saline attenuates acute kidney injury after liver transplantation via activating p53-mediated autophagy Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation Hydrogen-Rich Saline Attenuates Acute Renal Injury in Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting ROS and NF-κB Pathway Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling pathway Hydrogen rich water attenuates renal injury and fibrosis by regulation transforming growth factor-β induced Sirt1 Hydrogen-rich saline promotes the recovery of renal function after ischemia/reperfusion injury in rats via anti-apoptosis and anti-inflammation Preventive effect of hydrogen water on the development of detrusor overactivity in a rat model of bladder outlet obstruction Saturated hydrogen improves lipid metabolism disorders and dysbacteriosis induced by a high-fat diet Subcutaneous injection of hydrogen gas is a novel effective treatment for type 2 diabetes L-Arabinose elicits gut-derived hydrogen production and 16 Oxidative Medicine and Cellular Longevity ameliorates metabolic syndrome in C57BL/6J mice on highfat-diet Hydrogen gas production is associated with reduced interleukin-1β mRNA in peripheral blood after a single dose of acarbose in Japanese type 2 diabetic patients Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice Hydrogen attenuates allergic inflammation by reversing energy metabolic pathway switch Pilot study: effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes Intravenous infusion of H2-saline suppresses oxidative stress and elevates antioxidant potential in thoroughbred horses after racing exercise Involvement of neutrophil dynamics and function in exercise-induced muscle damage and delayed-onset muscle soreness: effect of hydrogen bath Protective effect of hydrogen gas inhalation on muscular damage using a mouse hindlimb ischemia-reperfusion injury model Molecular hydrogen alleviates motor deficits and muscle degeneration in mdx mice Protective effect of inhalation of hydrogen gas on radiation-induced dermatitis and skin injury in rats Hydrogen gas inhalation protects against cutaneous ischaemia/reperfusion injury in a mouse model of pressure ulcer Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: a report of three cases Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species Molecular hydrogen effectively heals alkali-injured cornea via suppression of oxidative stress High throughput siRNA screening for chloropicrin and hydrogen fluoride-induced cornea epithelial cell injury Therapeutic effect of molecular hydrogen in corneal UVB-induced oxidative stress and corneal photodamage Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stemlike cell differentiation Therapeutic efficacy of hydrogen-rich saline alone and in combination with PI3K inhibitor in non-small cell lung cancer A gallbladder carcinoma patient with pseudo-progressive remission after hydrogen inhalation Brain metastases completely disappear in non-small cell lung cancer using hydrogen gas inhalation: a case report Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice Hydrogen protects rats from dermatitis caused by local radiation Pathological findings of COVID-19 associated with acute respiratory distress syndrome Strategies for the prevention and management of coronavirus disease 2019 Hydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses Effect of shikonin on spinal cord injury in rats via regulation of HMGB1/TLR4/NF-kB signaling pathway Hydrogen-rich saline attenuates cardiac and hepatic injury in doxorubicin rat model by inhibiting inflammation and apoptosis Estimation of the hydrogen concentration in rat tissue using an airtight tube following the administration of hydrogen via various routes Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement Hydrogen inhalation ameliorates ventilator-induced lung injury Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice Allergic airway inflammation induces migration of mast cell populations into the mouse airway Hydrogen water ameliorates the severity of atopic dermatitis-like lesions and decreases interleukin-1β, interleukin-33, and mast cell infiltration in NC/Nga mice Hydrogen treatment protects mice against chronic pancreatitis by restoring regulatory T cells loss Inhalation of hydrogen gas elevates urinary 8-hydroxy-2′-deoxyguanine in Parkinson's disease Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats Hydrogen and oxygen mixture to improve cardiac dysfunction and myocardial pathological changes induced by intermittent hypoxia in rats Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases Beneficial biological effects and the underlying mechanisms of molecular hydrogen -comprehensive review of 321 original articles Molecular hydrogen suppresses free-radical-induced cell death by mitigating fatty acid peroxidation and mitochondrial dysfunction Hydrogen inhalation protects against acute lung injury induced by hemorrhagic shock and resuscitation Hydrogen gas inhalation attenuates seawater instillation-induced acute lung injury via the Nrf2 pathway in rabbits Therapeutic efficacy of molecular hydrogen: a new mechanistic insight Hydrogen gas attenuates myocardial ischemia reperfusion injury independent of postconditioning in rats by attenuating endoplasmic reticulum stress-induced autophagy Propofol inhibits parthanatos via ROS-ER-calcium-mitochondria signal pathway in vivo and vitro Inhalation of hydrogen of different concentrations ameliorates spinal cord injury in mice by protecting spinal cord neurons from apoptosis, oxidative injury and mitochondrial structure damages Neuroprotective effect of hydrogen-rich saline in global cerebral ischemia/reperfusion rats: up-regulated Tregs and down-regulated miR-21, miR-210 and NF-κB expression Loading MiR-210 in endothelial progenitor cells derived exosomes boosts their beneficial effects on hypoxia/reoxygeneation-injured human endothelial cells via protecting mitochondrial function MicroRNA-210 is upregulated in hypoxic cardiomyocytes through Akt-and p53-dependent pathways and exerts cytoprotective effects Pilot study of H 2 therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress Molecular hydrogen: new antioxidant and antiinflammatory therapy for rheumatoid arthritis and related diseases Open-label trial and randomized, double-blind, placebocontrolled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques Hydrogen-rich saline ameliorates allergic rhinitis by reversing the imbalance of Th1/Th2 and up-regulation of CD4+CD25+Foxp3+regulatory T cells, interleukin-10, and membrane-bound transforming growth factor-β in guinea pigs Immunological effect of hydrogen gas-hydrogen gas improves clinical outcomes of cancer patients Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress Effects of hydrogen-rich water on the PI3K/AKT signaling pathway in rats with myocardial 12 Oxidative Medicine and Cellular Longevity ischemia-reperfusion injury Attenuation of cardiac ischaemiareperfusion injury by treatment with hydrogen-rich water Saturated hydrogen saline attenuates endotoxin-induced lung dysfunction Hydrogen saline suppresses neuronal cell apoptosis and inhibits the p38 mitogen-activated protein kinase-caspase-3 signaling pathway following cerebral ischemia-reperfusion injury Hydrogen gas inhibits lung cancer progression through targeting SMC3 Influence of hydrogenoccluding-silica on migration and apoptosis in human esophageal cells in vitro Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagydependent pathway Hydrogen protects against chronic intermittent hypoxia induced renal dysfunction by promoting autophagy and alleviating apoptosis Effects of hydrogen rich water on the expression of Nrf 2 and the oxidative stress in rats with traumatic brain injury TLR4 mediates the impairment of ubiquitin-proteasome and autophagy-lysosome pathways induced by ethanol treatment in brain Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases Hydrogen gas inhalation attenuates sepsis-induced liver injury in a FUNDC1-dependent manner H 2 protects against lipopolysaccharide-induced cardiac dysfunction via blocking TLR4-mediated cytokines expression Atg7 deficiency intensifies inflammasome activation and pyroptosis in Pseudomonas Sepsis The endotoxin delivery protein HMGB1 mediates caspase-11-dependent lethality in sepsis Hydrogen-rich saline attenuates isoflurane-induced caspase-3 activation and cognitive impairment via inhibition of isoflurane-induced oxidative stress, mitochondrial dysfunction, and reduction in ATP levels Pyroptosis and apoptosis pathways engage in bidirectional crosstalk in monocytes and macrophages Ferroptosis: an iron-dependent form of nonapoptotic cell death Disulfiram/copper induces antitumor activity against both nasopharyngeal cancer cells and cancer-associated fibroblasts through ROS/MAPK and ferroptosis pathways HMGB1 regulates erastininduced ferroptosis via RAS-JNK/p38 signaling in HL-60/NRAS Q61L cells Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells Activation of glutathione peroxidase 4 as a novel anti-inflammatory strategy Genomics of circadian rhythms in health and disease Microbiota diurnal rhythmicity programs host transcriptome oscillations
    keywords: autophagy; cancer; cells; damage; effects; expression; gas; hydrogen; inhalation; injury; ischemia; liver; lung; model; molecular; oxidative; rats; reperfusion; saline; stress; treatment; water
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        item: #21 of 47
          id: cord-260348-83ftjqev
      author: Xu, Yinlan
       title: Cepharanthine and Curcumin inhibited mitochondrial apoptosis induced by PCV2
        date: 2020-09-18
       words: 3777
      flesch: 42
     summary: Therefore, in this study, from many natural compounds with clear chemical structure, traditional medicine plant source and specific biological activity, 13 compounds with antiviral potential were selected and tested in the model of PCV2 infected PK-15 cell to screen anti-PCV2 compounds in vitro. found that PCV2 induced mitochondrial apoptosis of PCV2 infected PK-15 cells and 293 T cells by increasing the activities of caspase-3 and caspase-9 and accelerating the release of cytochrome C (Cyto C) from mitochondria to cytoplasm [34] ; After PCV2 infected RAW264.7 cells, stress-related molecules such as ROS production and NO secretion were significantly increased [35] ; Previous studies have shown that PCV2 infection promotes the accumulation of ROS, which in turn inhibits the replication of PCV2 through the NF-κB pathway [36] .
    keywords: apoptosis; cells; cepharanthine; compounds; curcumin; group; pcv2; porcine; virus
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        item: #22 of 47
          id: cord-262759-ec2c25q3
      author: Hsieh, Yi-Ting
       title: Glucose-6-Phosphate Dehydrogenase (G6PD)-Deficient Epithelial Cells Are Less Tolerant to Infection by Staphylococcus aureus
        date: 2013-11-04
       words: 4861
      flesch: 38
     summary: Bacterial infection or treatment with septic plasma might induce mitochondrial dysfunction by the accumulation of reactive oxygen species (ROS) and nitric oxide radical (NO ． ) in lymphocytes or epithelial cells leading to cell apoptosis Redox imbalance may induce cell apoptosis and necrosis, thus highlighting the role of G6PD in defending against oxidative damage
    keywords: a549; aureus; cells; deficiency; figure; g6pd; infection; ros; treatment; vancomycin
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        item: #23 of 47
          id: cord-268122-74nj66vb
      author: Xie, Na
       title: NAD(+) metabolism: pathophysiologic mechanisms and therapeutic potential
        date: 2020-10-07
       words: 32145
      flesch: 32
     summary: Alzheimer disease Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau Nicotinamide mononucleotide adenylyltransferase uses its NAD(+) substrate-binding site to chaperone phosphorylated Tau Parkinson's disease psychosis: presentation, diagnosis and management Decreased sirtuin deacetylase activity in LRRK2 G2019S iPSCderived dopaminergic neurons Mitochondrial metabolism regulates microtubule acetylome and autophagy trough sirtuin-2: impact for Parkinson's disease The NAD+ precursor nicotinamide riboside rescues mitochondrial defects and neuronal loss in iPSC and fly models of Parkinson's disease Enhancing NAD(+) salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson's disease Phenothiazine normalizes the NADH/ NAD(+) ratio, maintains mitochondrial integrity and protects the nigrostriatal dopamine system in a chronic rotenone model of Parkinson's disease A novel treatment target for Parkinson's disease c-Jun N-terminal kinase (JNK)-mediated phosphorylation of SARM1 regulates NAD(+) cleavage activity to inhibit mitochondrial respiration SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease Implications of NAD metabolism in pathophysiology and therapeutics for neurodegenerative diseases Clinical features of Huntington's disease Huntington's disease-update on treatments Huntington's disease: a clinical review The neuropsychology of Huntington's disease PGC-1α, sirtuins and PARPs in Huntington's disease and other neurodegenerative conditions: NAD+ to rule them all trans-(-)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington disease Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration Impaired PGC-1alpha function in muscle in Huntington's disease PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function Nicotinamide improves motor deficits and upregulates PGC-1α and BDNF gene expression in a mouse model of Huntington's disease Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease Kynurenine pathway measurements in Huntington's disease striatum: evidence for reduced formation of kynurenic acid Antioxidant alternatives in the treatment of amyotrophic lateral sclerosis: a comprehensive review Evaluation of the NAD(+) biosynthetic pathway in ALS patients and effect of modulating NAD(+) levels in hSOD1-linked ALS mouse models ALS genes in the genomic era and their implications for FTD Is SOD1 loss of function involved in amyotrophic lateral sclerosis Oxidative stress in neurodegenerative diseases Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis Differential effects of mutant SOD1 on protein structure of skeletal muscle and spinal cord of familial amyotrophic lateral sclerosis: role of chaperone network The genetics and neuropathology of amyotrophic lateral sclerosis Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis Enhancing NAD+ salvage pathway reverts the toxicity of primary astrocytes expressing amyotrophic lateral sclerosis-linked mutant superoxide dismutase 1 and~90 μM for mitochondrial NAD + , respectively.
    keywords: acid; activation; activity; aging; als; biosynthesis; cancer; cd38; cells; clock; cycle; damage; disease; dna; enzymes; expression; fatty; function; gene; glucose; homeostasis; human; inflammation; inhibition; injury; insulin; levels; liver; metabolism; mice; mitochondrial; nad +; nadph; nampt; nicotinamide; nmn; oxidative; parps; pathway; production; protein; redox; regulation; repair; response; rna; role; ros; salvage; signaling; sirt1; sirtuins; stress; tissue; transcription
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        item: #24 of 47
          id: cord-268527-wbfnhedy
      author: Smith, Sylvia B.
       title: Transient hyperglycosylation of rhodopsin with galactose
        date: 1991-10-31
       words: 8572
      flesch: 54
     summary: ConA purified rhodopsin labeled with [%]methionine and [Hlglucosamine was incubated at 3 7°C for 42 hr with 20 IT of N-glycanase (Genzyme, Boston, MA) in 0.15% SDS, 10 mM /$mercaptoethanol, 100 ,LLM PMSF. The percentage of ConA purified rhodopsin which contained galactose was determined from the radioactivity of the rhodopsin band of the gels of the RCA eluate as c.ompared to the ConA gels for each treatment group.
    keywords: agarose; bovine; cona; galactose; golgi; oligosaccharide; rca; retinas; rhodopsin; ros; sample; treatment
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        item: #25 of 47
          id: cord-271939-m1ko4yal
      author: Rouco, Lara
       title: Pursuing the Elixir of Life: In Vivo Antioxidative Effects of Manganosalen Complexes
        date: 2020-08-10
       words: 10287
      flesch: 33
     summary: Thus, manganosalen complexes have been shown to exhibit superoxide dismutase, catalase, and glutathione peroxidase activities, and they could potentially facilitate the scavenging of excess reactive oxygen species (ROS), thereby restoring the redox balance in damaged cells and organs. The aim of this review is to focus on in vivo studies performed on manganosalen complexes and their activity on the treatment of several pathological disorders associated with oxidative damage.
    keywords: activity; antioxidant; catalase; complexes; damage; dismutase; effects; et al; euk-134; free; manganese; manganosalen; mice; oxidative; oxygen; ros; sod; stress; studies; superoxide
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        item: #26 of 47
          id: cord-273093-u79r80ip
      author: Laforge, Mireille
       title: Tissue damage from neutrophil-induced oxidative stress in COVID-19
        date: 2020-07-29
       words: 1350
      flesch: 27
     summary: ROS induce tissue damage, thrombosis and red blood cell dysfunction, which contribute to COVID-19 disease severity. ROS induce tissue damage, thrombosis and red blood cell dysfunction, which contribute to COVID-19 disease severity.
    keywords: covid-19; neutrophil; patients; ros
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        item: #27 of 47
          id: cord-273992-xddikzxs
      author: Wiseman, A.
       title: Avoidance of oxidative‐stress perturbation in yeast bioprocesses by proteomic and genomic biostrategies?
        date: 2004-11-10
       words: 2661
      flesch: 23
     summary: Each of such redox couples displays an experimentally determined redox potential (reduction oxidation potential) of a particular voltage under standard (defined) conditions of temperature and pressure (usually 25°C, pH 7AE0, 1 atm). A web of interactions is evident amongst biomolecules in micro-organisms, disturbance of such biomolecular webs by toxic substances is often the basis of the toxic manifestations seen as loss of homeostasis in pure cultures of micro-organisms.
    keywords: antioxidant; bioprocess; enzymes; micro; organisms; proteins; ros; species; yeast
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        item: #28 of 47
          id: cord-278846-nqj7ctk3
      author: Ogger, Patricia P.
       title: Macrophage metabolic reprogramming during chronic lung disease
        date: 2020-11-12
       words: 10150
      flesch: 16
     summary: The iron-y of iron overload and iron deficiency in chronic obstructive pulmonary disease Increased iron sequestration in alveolar macrophages in chronic obtructive pulmonary disease Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages Mitochondrial dysfunction in macrophages: A key to defective bacterial phagocytosis in COPD Alveolar macrophage immunometabolism and lung function impairment in smoking and chronic obstructive pulmonary disease Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways Alterations in adenosine metabolism and signaling in patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis The MIF antagonist ISO-1 attenuates corticosteroid-insensitive inflammation and airways hyperresponsiveness in an ozone-induced model of COPD Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model Mitochondrial iron chelation ameliorates cigarette smokeinduced bronchitis and emphysema in mice Cigarette smoke-induced changes to alveolar macrophage phenotype and function are improved by treatment with procysteine Progress in understanding mucus abnormalities in cystic fibrosis airways Lung inflammation in cystic fibrosis: pathogenesis and novel therapies Inflammation in cystic fibrosis: an update Inflammation and its genesis in cystic fibrosis Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis Inflammation, infection, and pulmonary function in infants and young children with cystic fibrosis Azithromycin reduces exaggerated cytokine production by M1 alveolar macrophages in cystic fibrosis Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/-mice CFTR-dependent defect in alternatively-activated macrophages in cystic fibrosis Characterization of macrophage activation states in patients with cystic fibrosis Pivotal Advance: Expansion of small sputum macrophages in CF: failure to express MARCO and mannose receptors Tgf-β1 inhibits Cftr biogenesis and prevents functional rescue of ΔF508-Cftr in primary differentiated human bronchial epithelial cells Series 'matrix metalloproteinases in lung health and disease': the role of matrix metalloproteinases in cystic fibrosis lung disease Glutathione and infection Systemic deficiency of glutathione in cystic fibrosis Iron accumulates in the lavage and explanted lungs of cystic fibrosis patients Transforming growth factorβ activation in the lung: Focus on fibrosis and reactive oxygen species Impaired defenses of neonatal mouse alveolar macrophage with cftr deletion are modulated by glutathione and TGFβ1 Human cystic fibrosis macrophages have defective calciumdependent protein kinase C activation of the NADPH oxidase, an effect augmented by burkholderia cenocepacia Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection Pseudomonas aeruginosa utilizes host-derived itaconate to redirect its metabolism to promote biofilm formation Pulmonary pathogens adapt to immune signaling metabolites in the airway Lipid metabolism in cystic fibrosis Alterations in immune response and PPAR/LXR regulation in cystic fibrosis macrophages Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4 ratio in children with cystic fibrosis Pro-resolving lipid mediator Resolvin D1 serves as a marker of lung disease in cystic fibrosis Metabolic reprograming of cystic fibrosis macrophages via the IRE1α arm of the unfolded protein response results in exacerbated inflammation Glutathione aerosol suppresses lung epithelial surface inflammatory cell-derived oxidants in cystic fibrosis Elevated Mirc1/Mir17-92 cluster expression negatively regulates autophagy and CFTR (cystic fibrosis transmembrane conductance regulator) function in CF macrophages Cysteamine re-establishes the clearance of Pseudomonas aeruginosa by macrophages bearing the cystic fibrosis-relevant F508del-CFTR mutation An overview of monitoring and supplementation of omega 3 fatty acids in cystic fibrosis Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis Oral DHA supplementation in ΔF508 homozygous cystic fibrosis patients Bioavailability and safety of a high dose of docosahexaenoic acid triacylglycerol of algal origin in cystic fibrosis patients: a randomized, controlled study Effect of an 8-month treatment with ω-3 fatty acids (eicosapentaenoic and docosahexaenoic) in patients with cystic fibrosis Long-term docosahexaenoic acid therapy in a congenic murine model of cystic fibrosis Idiopathic pulmonary fibrosis: Guidelines for diagnosis and clinical management have advanced from consensus-based in 2000 to evidence-based in 2011 Revealing the pathogenic and aging-related mechanisms of the enigmatic idiopathic pulmonary fibrosis: An integral model Macrophages: Friend or foe in idiopathic pulmonary fibrosis? Matrix metalloproteinase: An upcoming therapeutic approach for idiopathic pulmonary fibrosis Multiplex protein profiling of bronchoalveolar lavage in idiopathic pulmonary fibrosis and hypersensitivity pneumonitis Metalloproteinases in idiopathic pulmonary fibrosis Accumulation of damaged mitochondria in alveolar macrophages with reduced OXPHOS related gene expression in IPF Metabolic characterization and RNA profiling reveal glycolytic dependence of profibrotic phenotype of alveolar macrophages in lung fibrosis Glucose transporter-1 distribution in fibrotic lung disease: Association with [18F]-2-fluoro-2-deoxyglucose-PET scan uptake, inflammation, and neovascularization Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells Succinate: a metabolic signal in inflammation Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation Itaconate controls the severity of pulmonary fibrosis Reactive oxygen species as signaling molecules in the development of lung fibrosis Macrophages and iron metabolism The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size Delta-like 4 induces Notch signaling in macrophages: implications for inflammation Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis Production of superoxide and nitric oxide by alveolar macrophages in the bleomycin-induced interstitial pneumonia mice model Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosis Iron laden macrophages in idiopathic pulmonary fibrosis: the telltale of occult alveolar hemorrhage? Bronchoalveolar lavage (BAL) cells in idiopathic pulmonary fibrosis express a complex pro-inflammatory, pro-repair, angiogenic activation pattern, likely associated with macrophage iron accumulation The transferrin receptor CD71 delineates functionally distinct airway macrophage subsets during idiopathic pulmonary fibrosis TOLLIP, MUC5B, and the response to N-acetylcysteine among individuals with idiopathic pulmonary fibrosis Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis Safety and tolerability of acetylcysteine and pirfenidone combination therapy in idiopathic pulmonary fibrosis: A randomised, double-blind, placebo-controlled, phase 2 trial Metformin: an old dog with a new trick? Metformin attenuates lung fibrosis development via NOX4 suppression Metformin reverses established lung fibrosis in a bleomycin model Metformin does not affect clinically relevant outcomes in patients with idiopathic pulmonary fibrosis Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance Nitrated fatty acids reverse pulmonary fibrosis by dedifferentiating myofibroblasts and promoting collagen uptake by alveolar macrophages SARS-CoV-2 and viral sepsis: observations and hypotheses Complex immune dysregulation in COVID-19 patients with severe respiratory failure COVID-19: consider cytokine storm syndromes and immunosuppression The landscape of lung bronchoalveolar immune cells in COVID-19 revealed by single-cell RNA sequencing Severe acute respiratory syndrome (SARS) coronavirus-induced lung epithelial cytokines exacerbate SARS pathogenesis by modulating intrinsic functions of monocyte-derived macrophages and dendritic cells The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice Interaction of influenza virus with mouse macrophages Host defense mechanisms against influenza virus: interaction of influenza virus with murine macrophages in vitro Heparin inhibits intracellular Mycobacterium tuberculosis bacterial replication by reducing iron levels in human macrophages Pro-and anti-inflammatory cytokines in tuberculosis: a two-edged sword in TB pathogenesis Mycobacterial survival strategies in the phagosome: defence against host stresses Intracellular trafficking in mycobacterium tuberculosis and mycobacterium avium-infected macrophages HIF-1α Is an essential mediator of IFN-γ-dependent immunity to mycobacterium tuberculosis Infection with mycobacterium tuberculosis induces the Warburg effect in mouse lungs Cutting edge: mycobacterium tuberculosis induces aerobic glycolysis in human alveolar macrophages that is required for control of intracellular bacillary replication Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis Mycobacterium tuberculosis limits host glycolysis and IL-1β by restriction of PFK-M via MicroRNA-21 Fumarase deficiency causes protein and metabolite succination and intoxicates mycobacterium tuberculosis An essential bifunctional enzyme in Mycobacterium tuberculosis for itaconate dissimilation and leucine catabolism The effect of the host's iron status on tuberculosis Hereditary hemochromatosis results in decreased iron acquisition and growth by Mycobacterium tuberculosis within human macrophages A major role for ferroptosis in mycobacterium tuberculosis-induced cell death and tissue necrosis Small RNA profiling in mycobacterium tuberculosis identifies mrsi as necessary for an anticipatory iron sparing response PPAR-α activation mediates innate host defense through induction of TFEB and lipid catabolism Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny Mycobacterium tuberculosis induces the MIR-33 locus to reprogram autophagy and host lipid metabolism In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis Mycobacterium bovis bacillus Calmette-Guérin infection induces TLR2-dependent peroxisome proliferator-activated receptor γ expression and activation: functions in inflammation, lipid metabolism, and pathogenesis Mycobacterium tuberculosis activates human macrophage peroxisome proliferator-activated receptor γ linking mannose receptor recognition to regulation of immune responses Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice Statin therapy reduces the mycobacterium tuberculosis burden in human macrophages and in mice by enhancing autophagy and phagosome maturation Furthermore, post birth and during maturation, circulating monocytes do not significantly contribute to lung macrophage populations at homoeostasis 18 .
    keywords: acid; activation; airway; alveolar; ams; asthma; cells; chronic; copd; disease; fibrosis; human; infection; inflammation; ipf; iron; lung; macrophages; metabolic; patients; phenotype; production; pulmonary; tuberculosis
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        item: #29 of 47
          id: cord-288238-36hiiw91
      author: Keshavarz, Mohsen
       title: Metabolic host response and therapeutic approaches to influenza infection
        date: 2020-03-05
       words: 8165
      flesch: 26
     summary: Induction of protective immune response to intranasal administration of influenza virus-like particles in a mouse model Association of polymorphisms in inflammatory cytokines encoding genes with severe cases of influenza a/H1N1 and B in an Iranian population Acute encephalopathy associated with influenza and other viral infections Influenza vaccination for patients with chronic obstructive pulmonary disease: understanding immunogenicity, efficacy and effectiveness Effectiveness of influenza vaccines in asthma: a systematic review and meta-analysis The nutritional requirements for the propagation of poliomyelitis virus by the HeLa cell Energy metabolic disorder is a major risk factor in severe influenza virus infection: proposals for new therapeutic options based on animal model experiments Metabolic pathways of lung inflammation revealed by high-resolution metabolomics (HRM) of H1N1 influenza virus infection in mice Targeting metabolic reprogramming by influenza infection for therapeutic intervention Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species Influenza a virus PB1-F2 is involved in regulation of cellular redox state in alveolar epithelial cells Enhanced oxidative damage to DNA, lipids, and proteins and levels of some antioxidant enzymes, cytokines, and heat shock proteins in patients infected with influenza H1N1 virus Does influenza A infection increase oxidative damage Selenium levels, selenoenzyme activities and oxidant/antioxidant parameters in H1N1-infected children Lung histopathological findings in fatal pandemic influenza a (H1N1) Influenza virus replication in lung epithelial cells depends on redox-sensitive pathways activated by NOX4-derived ROS Oxidative stress in lungs of mice infected with influenza a virus Alterations in antioxidant defences in lung and liver of mice infected with influenza a virus Inhibition of reactive oxygen species production ameliorates inflammation induced by influenza a viruses via upregulation of SOCS1 and SOCS3 Inhibition of Nox2 oxidase activity ameliorates influenza a virus-induced lung inflammation Influenza a virus and TLR7 activation potentiate NOX2 oxidasedependent ROS production in macrophages Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy Dependence on O2-generation by xanthine oxidase of pathogenesis of influenza virus infection in mice Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD Alteration of copper-zinc superoxide dismutase 1 expression by influenza a virus is correlated with virus replication Inhibition of influenza infection by glutathione Influenza a virus replication is dependent on an antioxidant pathway that involves GSH and Bcl-2 Differential redox state contributes to sex disparities in the response to influenza virus infection in male and female mice Glutathione increase by the n-butanoyl glutathione derivative (GSH-C4) inhibits viral replication and induces a predominant Th1 immune profile in old mice infected with influenza virus Glutathione-redox balance regulates c-rel-driven IL-12 production in macrophages: possible implications in Antituberculosis immunotherapy The cytokine storm of severe influenza and development of immunomodulatory therapy Inflammatory Monocytes Drive Influenza A Virus-Mediated Lung Injury in Juvenile Mice Role of indoleamine-2, 3-dioxygenase in alpha/beta and gamma interferon-mediated antiviral effects against herpes simplex virus infections Effects of interferons and viruses on metabolism Dynamics of the cellular metabolome during human cytomegalovirus infection Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy Early enhanced glucose uptake in human cytomegalovirus-infected cells Respiration and ATP level in BHK21/13S cells during the earlist stages of rubella virus replication Primary effects of the rubella virus on the metabolism of BHK-21 cells grown in suspension cultures Mitochondrial and bioenergetic dysfunction in human hepatic cells infected with dengue 2 virus Respiration and glycolysis of human cells grown in tissue culture Some metabolic effects of poliomyelitis virus on tissue culture The aforementioned metabolic processes are not the only pathways affected by influenza virus infection.
    keywords: acid; activity; atp; cells; expression; fatty; glucose; glycolysis; increase; infection; influenza; metabolic; mice; pathways; production; replication; role; virus
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        item: #30 of 47
          id: cord-289034-yl3emjef
      author: Moro, Loredana
       title: Mitochondria at the Crossroads of Physiology and Pathology
        date: 2020-06-24
       words: 3794
      flesch: 23
     summary: Primary mitochondrial diseases develop as a consequence of germline mutations in mtDNA and/or nuclear DNA genes that encode proteins affecting mitochondrial functionality and energy production, including ETC proteins and proteins involved in mtDNA replication, such as POLG. Since then, a range of primary mitochondrial diseases has been described (reviewed in [15] ).
    keywords: cancer; cells; diseases; dysfunction; mitochondrial; mitophagy; mtdna; mutations; response
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        item: #31 of 47
          id: cord-291190-f6km3c7z
      author: Nasi, Aikaterini
       title: Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention
        date: 2020-06-18
       words: 3004
      flesch: 32
     summary: Hereby, based on literature review from the current pandemic and previous outbreaks with corona viruses we analyze the impact of the virus infection on cell stress responses and redox balance. Hereby, based on literature review from the current pandemic and previous outbreaks with corona viruses we analyze the impact of the virus infection on cell stress responses and redox balance.
    keywords: cell; covid-19; infection; production; responses; ros; sars; stress
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        item: #32 of 47
          id: cord-291559-h6czy5bh
      author: Koirala, Prashamsa
       title: Recent advances in pharmacological research on Ecklonia species: a review
        date: 2017-08-24
       words: 12291
      flesch: 22
     summary: Dieckol and PFF-A obtained from boiling water-and organic solvent extracts of EC and ES showed almost 9-and 7-fold stronger antioxidant activity than the standard butylhydroxytoluene, and 6-and 4-fold greater activity than l-ascorbic acid in molar concentration, Anti-inflammatory activity Ecklonia cava Dieckol Decreased blood glucose level Kang et al. Undaria pinnatifida and Ecklonia stolonifera Antibacterial activities of marine epibiotic bacteria isolated from brown algae of Japan Antioxidant and anti-inflammatory activities of ventol, a phlorotannin-rich natural agent derived from Ecklonia cava, and its effect on proteoglycan degradation in cartilage explant culture A new phlorotannin from the brown alga Ecklonia stolonifera Inhibitory phlorotannins from the edible brown alga Ecklonia stolonifera on total reactive oxygen species (ROS) generation Protective effect of marine algae phlorotannins against AAPH-induced oxidative stress in zebrafish embryo Dieckol isolated from brown seaweed Ecklonia cava attenuates type II diabetes in db/db mouse model Protective effect of dieckol isolated from Ecklonia cava against ethanol caused damage in vitro and in zebrafish model Phlorotannin-rich Ecklonia cava reduces the production of betaamyloid by modulating alpha-and gamma-secretase expression and activity Dieckol, a component of Ecklonia cava, suppresses the production of MDC/CCL22 via down-regulating STAT1 pathway in interferon-c stimulated HaCaT human keratinocytes Acetylcholinesterase inhibitory activity of phlorotannins isolated from the brown alga, Ecklonia maxima (Osbeck) Papenfuss Anti-HIV-1 activity of phlorotannin derivative 8,4 000 -dieckol from Korean brown alga Ecklonia cava Phlorotannins suppress adipogenesis in pre-adipocytes while enhancing osteoblastogenesis in pre-osteoblasts Role of ERK/MAPK signaling pathway in antiinflammatory effects of Ecklonia cava in activated human mast cell line-1 cells Enzyme-treated Ecklonia cava extract inhibits adipogenesis through the downregulation of C/EBPa in 3T3-L1 adipocytes Hepatoprotective constituents of the edible brown alga Ecklonia stolonifera on tacrine-induced cytotoxicity in HepG2 cells Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and anti-inflammatory properties
    keywords: activity; algae; anti; brown; cancer; cava; cells; dieckol; ecklonia; ecklonia cava; effects; et al; expression; extract; glucose; human; inhibited; inhibitory; marine; mice; oxidative; pff; phlorotannins; potential; production; protein; ros
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        item: #33 of 47
          id: cord-293319-oo0w6faj
      author: Seo, Youngsik
       title: Reactive-oxygen-species-mediated mechanism for photoinduced antibacterial and antiviral activities of Ag(3)PO(4)
        date: 2020-06-11
       words: 2923
      flesch: 46
     summary: Facile synthesis of rhombic dodecahedral AgX/ Ag 3 PO 4 (X = Cl, Br, I) heterocrystals with enhanced photocatalytic properties and stabilities Hydroxyapatite supported antibacterial Ag 3 PO 4 nanoparticles Visible light induced photocatalytic degradation of organic pollutants Methods and mechanism for improvement of photocatalytic activity and stability of Ag 3 PO 4 : a review Chemistry and biology of reactive oxygen species in signaling or stress responses A simple way for Ag 3 PO 4 tetrahedron and tetrapod microcrystals with high visible-light-responsive activity Proteins are major initial cell targets of hydroxyl free radicals Emerging organic contaminants in groundwater: a review of sources, fate and occurrence Mechanism of photogenerated reactive oxygen species and correlation with the antibacterial properties of engineered metal-oxide nanoparticles Hierarchical Ag 3 PO 4 porous microcubes with enhanced photocatalytic properties synthesized with the assistance of trisodium citrate Degradation of organic pollutants and microorganisms from wastewater using different dielectric barrier discharge configurations-a critical review Reactive oxygen species and hormonal control of cell death Are reactive oxygen species always detrimental to pathogens? In the presence of Ag 3 PO 4 crystals and under red-light (625 nm) irradiation, an E. coli growth curve very similar to that for Ag 3 PO 4 crystals under dark conditions is observed, where the half-maximal growth time is 12.0 h. Because the indirect bandgap energy of crystalline Ag 3 PO 4 is 2.36 eV (525 nm), the red light (625 nm, 1.98 eV) lacks sufficient energy to transfer the electron from the valance band to the conduction band of the Ag 3 PO 4 crystal.
    keywords: activity; antibacterial; blue; irradiation; light; presence
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        item: #34 of 47
          id: cord-295459-ffi1043k
      author: Khan, Naseem Ahmed
       title: Respiratory Syncytial Virus-Induced Oxidative Stress Leads to an Increase in Labile Zinc Pools in Lung Epithelial Cells
        date: 2020-05-27
       words: 6817
      flesch: 49
     summary: We did not observe any change in labile zinc levels in cells infected with DENV ( Fig. 1A and B) , suggesting that zinc homeostasis is altered specifically by RSV and IAV; RSV infection in particular led to increases in both cytosolic and vesicular labile zinc pools, whereas DENV infection had no effect in A549 cells. These results suggest that RSV infection triggers an increase in cellular free zinc levels that is time and MOI dependent; this increase in labile zinc levels is specific to RSV, as dengue infection had no effect.
    keywords: a549; cells; effect; fig; increase; infection; labile; levels; p.i; rsv; stress; virus; zinc
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        item: #35 of 47
          id: cord-297469-26d8o1xk
      author: Choi, Won Hyung
       title: The Mechanism of Action of Ursolic Acid as a Potential Anti-Toxoplasmosis Agent, and Its Immunomodulatory Effects
        date: 2019-05-09
       words: 7005
      flesch: 33
     summary: These changes demonstrate that UA promotes the production and the expression of IL-10 and IL-12 by consistently stimulating the immune cells as well as inhibit the expressions of IL-1β and IL-6 induced by T. gondii infection. These results indicate that UA not only effectively induces the production of cytokines between the immune cells by increasing the expression of IL-10 and IL-12 in macrophage and B cells after T. gondii infection, but also suppresses or strongly reduces the expression of the inflammatory cytokines from the immune cells.
    keywords: cells; cytokines; groups; infection; production; ros; t. gondii
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        item: #36 of 47
          id: cord-298265-elbnzgx6
      author: Mutua, Victoria
       title: A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics
        date: 2020-08-01
       words: 10425
      flesch: 29
     summary: formation Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens How neutrophils kill microbes Neutrophil extracellular traps (NET) induced by different stimuli: a comparative proteomic analysis Neutrophil extracellular traps profiles in patients with incident systemic lupus erythematosus and lupus nephritis Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps NLRP3 activation induced by neutrophil extracellular traps sustains inflammatory response in the diabetic wound The influence of hyperglycemia on neutrophil extracellular trap formation and endothelial Pathogenesis and therapy of psoriasis Neutrophil extracellular traps and their role in the development of chronic inflammation and autoimmunity Regulating neutrophil apoptosis: new players enter the game Mechanisms of B cell autoimmunity in SLE Systemic lupus erythematosus Immunological pathogenesis and treatment of systemic lupus erythematosus Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus Review article neutrophil function in an inflammatory milieu of rheumatoid arthritis Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis Proinflammatory mediators and neutrophils are increased in synovial fluid from heifers with acute ruminal acidosis NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis Rev Médica del Diabetes primes neutrophils to undergo NETosis, which impairs wound healing The adipose tissue as a source of vasoactive factors Adipocytes properties and crosstalk with immune system in obesity-related inflammation Neutrophil extracellular traps and cardiovascular diseases: an update Increased plasmatic NETs by-products in patients in severe obesity In vivo and in vitro studies on the roles of neutrophil extracellular traps during secondary pneumococcal pneumonia after primary pulmonary influenza infection Effect of high-fat diet on the formation of pulmonary neutrophil extracellular traps during influenza pneumonia in BALB/c mice Role of thromboxane-dependent platelet activation in venous thrombosis: aspirin effects in mouse model Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury Aspirin-triggered 15-epi-lipoxin a4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice Activation of platelet function through G protein-coupled receptors Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects against endotoxin-induced acute kidney injury Aspirin, but NotTirofiban displays protective effects in endotoxin induced lung injury Neutrophil extracellular traps are pathogenic in primary graft dysfunction after lung transplantation Regulation of neutrophil extracellular trap formation by anti-inflammatory drugs Mechanisms of action of cyclosporine Cyclosporine: a review Cyclosporine in veterinary dermatology Molecular mechanisms of action of some immunosuppressive drugs Efficient neutrophil extracellular trap induction requires mobilization of both intracellular and extracellular calcium pools and is modulated by cyclosporine A. PLoS One:9 Posttransplant infections in the tropical countries Molecular targeting of protein arginine deiminases to suppress colitis and prevent colon cancer AA et alPeptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice NETosis delays diabetic wound healing in mice and humans
    keywords: activation; cells; conditions; damage; disease; effects; extracellular; formation; histones; human; inflammation; inhibition; injury; mice; netosis; nets; neutrophil; patients; production; protein; studies; traps; treatment
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        item: #37 of 47
          id: cord-307148-k1uo3fxm
      author: Bradshaw, Patrick C.
       title: COVID-19: Proposing a Ketone-Based Metabolic Therapy as a Treatment to Blunt the Cytokine Storm
        date: 2020-09-09
       words: 20848
      flesch: 35
     summary: Therefore, R-BHB may mitigate respiratory virus infection both by increasing LL-37 levels and by increasing NADPH levels [16] that protect LL-37 from inactivation. Increased NADPH levels also have been shown to stimulate antiviral immunity by decreasing the level of the NADPH sensor protein HSCARG, which is a negative regulator of NF-κB transcription.
    keywords: acid; activity; bhb; cells; covid-19; cytokine; decrease; diet; effects; expression; fat; function; gene; glucose; iav; increase; infection; inflammatory; inhibition; ketogenic; ketone; levels; lung; macrophages; metabolism; mice; mitochondrial; nadph; production; response; ros; sars; signaling; storm
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        item: #38 of 47
          id: cord-310723-ogo9mvi5
      author: Belinskaia, Daria A.
       title: The Universal Soldier: Enzymatic and Non-Enzymatic Antioxidant Functions of Serum Albumin
        date: 2020-10-09
       words: 13805
      flesch: 41
     summary: Free Radic Delineating the Role of Glutathione Peroxidase 4 in Protecting Cells Against Lipid Hydroperoxide Damage and in Alzheimer's Disease Promoter Hypermethylation and Suppression of Glutathione Peroxidase 3 Are Associated with Inflammatory Breast Carcinogenesis Downregulation of glutathione peroxidase 3 is associated with lymph node metastasis and prognosis in cervical cancer Crystallographic Analysis of Human Serum Albumin Complexed with 4Z,15E-Bilirubin-IXα Albumin-bilirubin binding mechanism Conformational Changes of Human Serum Albumin by Binding of Small Molecules Determining the binding site and binding affinity of estradiol to human serum albumin and holo-transferrin: Fluorescence spectroscopic, isothermal titration calorimetry and molecular modeling approaches Spectroscopic Studies of the Effects of Glycation of Stereoselective kinetics of warfarin binding to human serum albumin: Effect of an allosteric interaction Human Serum Albumin Conformational Changes as Induced by Tenoxicam and Modified by Simultaneous Diazepam Binding Chemical modification of human albumin at cys34 by ethacrynic acid: Structural characterisation and binding properties Effect of oxidative stress on the structure and function of human serum albumin Effects of Oxidation of Human Serum Albumin on the Binding of Aripiprazole Physiological and pathological changes in the redox state of human serum albumin critically influence its binding properties Close relationship between redox state of human serum albumin and serum cysteine levels in non-diabetic CKD patients with various degrees of renal function Albumin-binding function is reduced in patients with decompensated cirrhosis and correlates inversely with severity of liver disease assessed by model for end-stage liver disease Cys34-Cysteinylated Human Serum Albumin Is a Sensitive Plasma Marker in Oxidative Stress-Related Chronic Diseases Glucose metabolism and liver cirrhosis Modification of albumin with different degrees of the oxidation of SH-groups in the reaction with glucose Albumin as Fatty Acid Transporter Spectroscopic analysis of the impact of oxidative stress on the structure of human serum albumin (HSA) in terms of its binding properties Alterations in conformational state of albumin in plasma in chronic hemodialyzed patients A New Structural Transition of Serum Albumin Dependent on the State of Cys34. Metabolites Quantitative Profiling of Polar Metabolites in Herbal Medicine Injections for Multivariate Statistical Evaluation Based on Independence Principal Component Analysis Quantitative NMR analysis of intraand extracellular metabolism of mammalian cells: A tutorial Role of Tyr84 in controlling the reactivity of Cys34 of human albumin The thiol of human serum albumin: Acidity, microenvironment and mechanistic insights on its oxidation to sulfenic acid.
    keywords: acid; albumin; amino; antioxidant; binding; bsa; cys34; cysteine; figure; group; hsa; human; oxidation; oxidative; plasma; properties; protein; redox; rsa; serum albumin; site; structure; sudlow; thiol
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        item: #39 of 47
          id: cord-313825-bbjxd86y
      author: Xia, Tian
       title: Pulmonary diseases induced by ambient ultrafine and engineered nanoparticles in twenty-first century
        date: 2016-10-08
       words: 8770
      flesch: 42
     summary: In a recent study, Chen et al. presented findings that implicated long-term exposure to air pollution particles contributed to enormous loss of life expectancy in China These results were based on an experimental design making use of a Chinese policy that provided free coal for heating in cities located north of Huai River, but not in the south, which produced an arbitrary discontinuity for PM air pollution, where the major difference was coal combustion.
    keywords: air; air pollution; ambient; effects; exposure; health; lung; mortality; nanoparticles; nps; particles; pollution; ros; stress; studies; surface; ufps
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        item: #40 of 47
          id: cord-313918-uv9xdp5f
      author: Marí, Montserrat
       title: Mitochondrial Glutathione: Recent Insights and Role in Disease
        date: 2020-09-24
       words: 10398
      flesch: 26
     summary: Free Radic Visualization of the compartmentalization of glutathione and protein-glutathione mixed disulfides in cultured cells Regulation and Functions Glutathione and mitochondria Mitochondrial glutathione: Features, regulation and role in disease Glutaredoxin systems Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4 Programmed cell-death by ferroptosis: Antioxidants as mitigators Chemical basis of reactive oxygen species reactivity and involvement in neurodegenerative diseases GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis Mitochondrial thiols in antioxidant protection and redox signaling: Distinct roles for glutathionylation and other thiol modifications Isoforms of mammalian peroxiredoxin that reduce peroxides in presence of thioredoxin Mitochondrial thioredoxin-2/peroxiredoxin-3 system functions in parallel with mitochondrial GSH system in protection against oxidative stress Protein S-glutathionylation reactions as a global inhibitor of cell metabolism for the desensitization of hydrogen peroxide signals Enrichment and functional reconstitution of glutathione transport activity from rabbit kidney mitochondria. The physiological relevance of keeping mitochondrial oxidative stress and redox status is paramount, as evidenced by the fact that the knock-out mice of the mitochondrial enzymes GPx4 (also known as phospholipid hydroperoxide glutathione peroxidase) or TrxR2 are embryonic lethal [28] .
    keywords: addition; aging; cell; death; depletion; disease; glutathione; gsh; levels; liver; membrane; mgsh; mitochondrial; protein; redox; role; ros; stress; transport
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        item: #41 of 47
          id: cord-316244-s5ua0re3
      author: Park, Mi Hee
       title: Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases
        date: 2016-04-26
       words: 19265
      flesch: 30
     summary: PRDX isoforms can be considered good therapeutic targets in several cancers such as lung cancer (Jo et al., 2013; Kim et al., 2007; Soini & Kinnula, 2012; Wei et al., 2011) , glioblastoma (Deighton et al., 2014; Khalil, 2007) , colorectal cancer (Lu et al., 2014a (Lu et al., , 2014b Song et al., 2015) , prostate cancer (Riddell et al., 2011; Ummanni et al., 2012) and ovarian cancer (Chung et al., 2010; where they protect tumor cells, PRDXs are involved in a variety of signaling pathways such as NF-κB signaling pathway, STAT3 pathway, wnt/β-catenin pathway and MAPK kinase pathways (Brigelius-Flohé & Flohé, 2011; Jo et al., 2013; Lu et al., 2014b; Riddell, Wang, Minderman, & Gollnick, 2010; Yun, Choi, Oh, & Hong, 2015c; Yun, Park, Kim, & Hong, 2015b; Yun et al., 2015a) that are involved in cancer development. Ho et al., 2010; Jo et al., 2013; Yun et al., 2014a Yun et al., , 2014b Yun et al., 2015c Yun et al., , 2015b Yun et al., , 2015a PRDX4 is supposed to play a role in the most aggressive primary brain malignancy .
    keywords: activation; activity; apoptosis; breast; cancer; cancer cells; carcinoma; cells; development; diseases; et al; expression; human; lung; mice; mitochondrial; pathway; peroxiredoxin; phosphorylation; prdx6; protein; regulation; role; ros; signaling; stress; study; tumor; yun et
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        item: #42 of 47
          id: cord-319614-4qi59pbz
      author: Benej, Martin
       title: Quantitative Proteomics Reveal Peroxiredoxin Perturbation Upon Persistent Lymphocytic Choriomeningitis Virus Infection in Human Cells
        date: 2019-10-25
       words: 8920
      flesch: 38
     summary: A highly suitable tool to study virus-host cell interactions is proteomics, since viral infection fundamentally affects host cell proteins. Using a luciferase reporter containing HRE, we detected a modest, but significant increase in HIF-1 transactivation in infected HeLa cells in comparison to control cells ( Figure 7A) .
    keywords: akt; analysis; cells; choriomeningitis; et al; figure; gel; hela; host; infection; lcmv; levels; min; persistent; protein; ros; signaling; virus
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        item: #43 of 47
          id: cord-320591-re99v1qt
      author: Le, Thanh Ninh
       title: Bioactive Compounds and Bioactivities of Brassica oleracea L. var. Italica Sprouts and Microgreens: An Updated Overview from a Nutraceutical Perspective
        date: 2020-07-27
       words: 8198
      flesch: 30
     summary: Agriculture (Polnohospodárstvo) Response surface optimization and identification of isothiocyanates produced from broccoli sprouts Free radical scavenging, antiproliferative activities and profiling of variations in the level of phytochemicals in different parts of broccoli (Brassica oleracea italica) Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract Optimisation of enzymatic production of sulforaphane in broccoli sprouts and their total antioxidant activity at different growth and storage days Comparative Study of Predominant Phytochemical Compounds and Proapoptotic Potential of Broccoli Sprouts and Florets Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells Effect of broccoli sprouts on thyroid function, haematological, biochemical, and immunological parameters in rats with thyroid imbalance Antiproliferative Effect of Bioaccessible Fractions of Four Brassicaceae Microgreens on Human Colon Cancer Cells Linked to Their Phytochemical Composition Sorting out the value of cruciferous sprouts as sources of bioactive compounds for nutrition and health Phenolic acids: Natural versatile molecules with promising therapeutic applications Effect of bioaccessibility of phenolic compounds on in vitro anticancer activity of broccoli sprouts Influence of Sodium and Maturity Stage on the Antioxidant Properties of Cauliflower and Broccoli Sprouts Phenolic profile and antioxidant activity in selected seeds and sprouts Energy Regulated Nutritive and Antioxidant Properties during the Germination and Sprouting of Broccoli Sprouts (Brassica oleracea var. It could be summarized that glucosinolates and related compounds are the major group of phytochemicals investigated in broccoli sprouts and microgreens, although phenolic compounds have also been analyzed in many studies ( Figure 2 ).
    keywords: activity; antioxidant; broccoli; broccoli sprouts; cancer; cells; compounds; effects; food; glss; glucosinolates; health; microgreens; seedlings; sprouts; studies; sulforaphane; vivo
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        item: #44 of 47
          id: cord-323730-5iawbnua
      author: Ohl, Kim
       title: Oxidative stress in multiple sclerosis: Central and peripheral mode of action
        date: 2016-03-31
       words: 9194
      flesch: 29
     summary: In line with these findings, sustained pro-oxidant extracellular conditions have been shown to inhibit T cell activation (Matsue et al., 2003; Tse et al., 2007) and induce apoptosis in T cells (Hildeman et al., 1999; This reducing extracellular milieu boosts T cell response and proliferation, thus showing that ROS production plays a key role in regulating surface redox levels on T cells and thereby suppresses autoreactivity.
    keywords: activation; cells; disease; effects; et al; immune; levels; nrf2; oxidative; patients; redox; reg; ros; sclerosis; stress; t cells
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        item: #45 of 47
          id: cord-331673-xv1tcugl
      author: Reina, Giacomo
       title: Hard Nanomaterials in Time of Viral Pandemics
        date: 2020-07-15
       words: 15723
      flesch: 39
     summary: Different functionalized CDs were prepared to hamper host cell viral entry. Overall, graphene materials have shown a good capacity to block host cell viral entry.
    keywords: activity; agents; agnps; cells; drug; effect; entry; fullerene; hiv; hnms; host; host cells; immune; infection; influenza; inhibition; interaction; mechanism; nanoparticles; replication; response; silver; surface; virus; viruses; vitro
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        item: #46 of 47
          id: cord-335676-7ak53hto
      author: Meftahi, Gholam Hossein
       title: The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”
        date: 2020-06-11
       words: 8220
      flesch: 40
     summary: The number of immune cells also changed in COVID-19 infection [29, 30] . In healthy adults, due to sufficient vitamin D level, VD can decrease the expression of pro-inflammatory genes in immune cells.
    keywords: ace2; adults; age; aging; cells; covid-19; cytokines; expression; immune; infection; inflammation; lymphocytes; patients; pro; storm
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        item: #47 of 47
          id: cord-336201-fl606l3b
      author: Daryabor, Gholamreza
       title: The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System
        date: 2020-07-22
       words: 13880
      flesch: 25
     summary: The endocrine part is made of different cell types, including α, β, δ, and ε cells that secrete glucagon, insulin, somatostatin, and ghrelin hormones, respectively. A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts Humanin prevents high glucose-induced monocyte adhesion to endothelial cells by targeting KLF2 Novel clearance mechanisms of platelets Flow cytometric analysis of platelets type 2 diabetes mellitus reveals 'angry' platelets Platelet activity and hypercoagulation in type 2 diabetes Increased circulating resistin is associated with insulin resistance, oxidative stress and platelet activation in type 2 diabetes mellitus Increased levels of soluble adhesion molecules in type 2 (non-insulin dependent) diabetes mellitus are independent of glycaemic control Molecular mechanisms underpinning microparticle-mediated cellular injury in cardiovascular complications associated with diabetes Association between mean platelet volume in the pathogenesis of type 2 diabetes mellitus and diabetic macrovascular complications in Japanese patients Increased erythrocyte-and platelet-derived microvesicles in newly diagnosed type 2 diabetes mellitus Type 2 diabetes and cardiovascular disease: have all risk factors the same strength? Advanced glycation end products induce a prothrombotic phenotype in mice via interaction with platelet CD36 Central role of the P2Y12 receptor in platelet activation Long non-coding RNA metallothionein 1 pseudogene 3 promotes p2y12 expression by sponging miR-126 to activate platelet in diabetic animal model Introduction to the human gut microbiota Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection Faecalibacterium prausnitzii-derived microbial anti-inflammatory molecule regulates intestinal integrity in diabetes mellitus mice via modulating tight junction protein expression Considering gut microbiota in treatment of type 2 diabetes mellitus Metformin effect on gut microbiota: insights for HIV-related inflammation The bacterium Akkermansia muciniphila: a sentinel for gut permeability and its relevance to HIV-related inflammation High glucose decreases intracellular glutathione concentrations and upregulates inducible nitric oxide synthase gene expression in intestinal epithelial cells The role of iron in diabetes and its complications Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKCalpha-dependent manner Betacell deficit and increased beta-cell apoptosis in humans with type 2 diabetes Fatty acid-induced lipotoxicity in pancreatic beta-cells during development of type 2 diabetes Mesenchymal stem cell therapy in type 2 diabetes mellitus Establishment of insulin-producing cells from human embryonic stem cells underhypoxic condition for cell based therapy Human mesenchymal stem cell derived exosomes alleviate type 2 diabetes mellitus by reversing peripheral insulin resistance and relieving β-cell destruction A simple method for the generation of insulin producing cells from bone marrow mesenchymal stem cells Secretagogin affects insulin secretion in pancreatic beta-cells by regulating actin dynamics and focal adhesion Secretagogin regulates insulin signaling by direct insulin binding.
    keywords: cells; diabetes; diabetes mellitus; disease; dm patients; dysfunction; endothelial; et al; expression; glucose; human; immune; individuals; infections; inflammation; insulin; levels; macrophages; mellitus; mice; patients; resistance; risk; role; t2 dm; type
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