# bib

id: cord-033064-3b4jv1zb
author: Larsen, Reinhard
title: Sepsis und septischer Schock
date: 2016-06-14
extension: .txt
mime: text/plain
words: 340
sentence: 26
flesch: 50
cache: cache/cord-033064-3b4jv1zb.txt
txt: txt/cord-033064-3b4jv1zb.txt
summary:
  Schock, einer Unterform der Sepsis, muss die Herz-Kreislauf-Funktion mit kardiovaskulären Medikamenten und Volumenersatz gestützt werden. Trotz intensiver Bemühungen ist die Letalität der Sepsis unverändert hoch.


id: cord-014658-oeuvelb1
author: Martin, Greg S.
title: Optimal fluid management in sepsis
date: 2019-11-07
extension: .txt
mime: text/plain
words: 889
sentence: 37
flesch: 41
cache: cache/cord-014658-oeuvelb1.txt
txt: txt/cord-014658-oeuvelb1.txt
summary:
  Albumin may be considered for administration to sepsis patients with refractory shock or who have received substantial amounts of crystalloid fluids, but should not be administered to patients with severe traumatic brain injury.(5) Albumin may be considered for administration to sepsis patients with refractory shock or who have received substantial amounts of crystalloid fluids, but should not be administered to patients with severe traumatic brain injury.


id: cord-018284-grvj99eh
author: Fresenius, Michael
title: SIRS, Sepsis und Multiorganversagen
date: 2014-10-04
extension: .txt
mime: text/plain
words: 1026
sentence: 24
flesch: 14
cache: cache/cord-018284-grvj99eh.txt
txt: txt/cord-018284-grvj99eh.txt
summary:
  Update A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-centre study Higher versus lower positive end-expiratory pressures in patients with acute respiratory distress syndrome Diagnostic approach to sepsis -state of the art Aktuelle Aspekte und Zukunft der Sepsisdiagnose Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis Diagnosis of sepsis: an evidence-based review Effects of drotrecogin alfa activated on microcirculation alterations in patients with severe sepsis Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock Cardiovascular management of septic shock Glucose Control in Critically Ill Patients Effects of high dosis of selenium, as sodium selenit, in septic shock: a placebo-controlled, randomized, double-blind, phase II study Aktivated protein C (Xigris) treatment in sepsis: d drug in trouble Sepsis: state of the art Crit Care 16 R94 und Annane Djilllali CRYSTMAS study adds to concerns about renal safety and increased mortality in sepsis patients Diagnostic value of procalcitonin, interleukin 6 and interleukin-8 in critically ill patients admitted with suspected sepsis The pathophysiology and treatment of sepsis Immunologic and hemodynamic effects of »low-dose« hydrocortisone in septic shock: a doubleblind, randomized, placebo-controlled, crossover study High dose vasopressin is not superior to norepinephrine in septic shock Immunmodulatory therapies in sepsis Early antimicrobial therapy in severe sepsis and septic shock SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference Multiple-center, randomized, placebocontrolled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock The Epidemiology of Sepsis in the United States from 1979 through 2000 Definition of sepsis Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care The Problems and Challenges of Immunotherapy in Sepsis Lactate in the critically ill patients: an outcome marker with the times Terlipressin for norepinephrin-resistant septic shock Beneficial effects of shortterm vasopressin infusion during severe septic shock Hydroxyethyl Starch 130/0.42 versus Ringer's Acetate in Severe Sepsis Hydroxyethylstarch and Ringer's lactate for fluid resuscitation in patients with severe sepsis -results from the VISEP-Study Diagnose und Therapie der Sepsis Therapie und Nachsorge der Sepsis (2010) Der Immunstatus kann anhand folgender Faktoren bestimmt werden: 4 Interleukin-6-Spiegel 4 Ausmaß der HLA-DR-Expression (Immunstimulation durch GM-CSF-Gabe zur Steigerung der Immunantwort oder Gabe von APC im Rahmen der Hyperfibrinolyse) 4 ex vivo TNF-Anstieg nach LPS-Gabe Verzicht auf intravenöse Selen-Gabe 2C Verzicht auf die Gabe von aktivierten Protein C (rhAPC) Drotrecogin alfa (activated) for adults with severe sepsis and low risk of death Empfehlungen zur Diagnostik und Therapie der Schockformen der IAG Schock der DIVI Critical illness Polyneuropathie und Criticall Illness Myopathy Epidemiology of sepsis and infection in ICU patients from international multicentre cohort study Intravenous immunoglobuline for treating sepsis and septic shock.


id: cord-006414-60lpjg09
author: Engelmann, L.
title: Die Diagnose der Sepsis
date: 2006
extension: .txt
mime: text/plain
words: 1299
sentence: 50
flesch: 34
cache: cache/cord-006414-60lpjg09.txt
txt: txt/cord-006414-60lpjg09.txt
summary:
  Patienten mit Inflammationreaktion septischer und nicht-septischer Genese unterscheiden sich nicht im CRP-Verlauf (Abb. 4), während bei gesicherter Sepsis dem CRP-Verhalten eine prognostische Bedeutung zukommt (Abb. 5; [41, 50] ) Die Inflammationsreaktion ist eine weitestgehend uniforme Reaktion des Organismus auf Schädigung. key: cord-006414-60lpjg09 authors: Engelmann, L. title: Die Diagnose der Sepsis date: 2006 journal: Intensivmed Notfallmed DOI: 10.1007/s00390-006-0741-y sha: doc_id: 6414 cord_uid: 60lpjg09 The early diagnosis of sepsis is mandatory for the further reduction of mortality due to sepsis.


id: cord-005697-l1zmrq4p
author: Pène, Frédéric
title: Is this critically ill patient immunocompromised?
date: 2015-12-02
extension: .txt
mime: text/plain
words: 1346
sentence: 49
flesch: 21
cache: cache/cord-005697-l1zmrq4p.txt
txt: txt/cord-005697-l1zmrq4p.txt
summary:
  Timing and causes of death in septic shock Genetic influences on incidence and case-fatality of infectious disease Epigenetic programming of monocyteto-macrophage differentiation and trained innate immunity The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia Specific MAIT cell behaviour among innate-like T lymphocytes in critically ill patients with severe infections Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy Reactivation of multiple viruses in patients with sepsis Innate immune dysfunction in trauma patients: from pathophysiology to treatment Temporary withdrawal of immunosuppression for life-threatening infections after liver transplantation Monocytic HLA-DR expression in intensive care patients: interest for prognosis and secondary infection prediction Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebocontrolled multicenter trial Elevated plasmatic level of soluble IL-7 receptor is associated with increased mortality in septic shock patients Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock IL-7 restores lymphocyte functions in septic patients Case series and small trials indicate that immunostimulating compounds are able to restore immune function and may exert beneficial clinical effects in sepsis patients, while no overt safety issues have been reported [12, 13] .


id: cord-104180-f3hoz9bu
author: Kirk-Bayley, Justin
title: Recently published papers: inflammation, elucidation, manipulation?
date: 2003-07-03
extension: .txt
mime: text/plain
words: 1549
sentence: 66
flesch: 37
cache: cache/cord-104180-f3hoz9bu.txt
txt: txt/cord-104180-f3hoz9bu.txt
summary:
  Glucocorticoid insufficiency in patients who present to the hospital with severe sepsis: a prospective clinical trial Adrenocortical hormones in survivors and nonsurvivors of severe sepsis: diverse time course of dehydroepiandrosterone, dehydroepiandrosterone-sulfate, and cortisol Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery Coagulation blockade prevents sepsis-induced respiratory and renal failure in baboons Blockade of tissue factor: treatment for organ injury in established sepsis Development of ionized hypomagnesemia is associated with higher mortality rates Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experi-Critical Care Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial Prevention of endotracheal suctioning-induced alveolar derecruitment in acute lung injury Dose-response characteristics during long-term inhalation of nitric oxide in patients with severe acute respiratory distress syndrome: a prospective, randomized, controlled study Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: Which is best? Bad medicine: low-dose dopamine in the ICU On the physiologic and clinical relevance of lung-borne cytokines during ventilator-induced lung injury Discrepancies between perceptions by physicians and nursing staff of intensive care unit end-of-life decisions A randomized trial of inhaled nitric oxide to prevent ischemia-reperfusion injury after lung transplantation Activated protein C inhibits the expression of platelet-derived growth factor in the lung Treatment of acute respiratory distress syndrome with recombinant surfactant protein C surfactant Impact of randomized trial results on acute lung injury ventilator therapy in teaching hospitals None declared. Looking at reduced endogenous steroid levels in sepsis, Marx and coworkers [2] focused on the androgens dehydroepiandrosterone (DHEA) and its sulphated precursor (DHEAS) and looked at disparity between survivors and nonsurvivors from severe sepsis.


id: cord-270213-ygb64yxc
author: Williams, Alexander T.
date: 2020-10-02
extension: .txt
mime: text/plain
words: 2309
sentence: 64
flesch: 23
cache: cache/cord-270213-ygb64yxc.txt
txt: txt/cord-270213-ygb64yxc.txt
title:
  Control of systemic inflammation throughearly nitric oxide supplementation with nitric oxide releasing nanoparticles

summary:
  477 478 Conclusion 479 Pathogenetic Mechanisms of Septic Shock 506 Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and 507 associated costs of care Epidemiology of severe sepsis Severe Sepsis and Septic Shock Sepsis and endothelial permeability Novel therapies for microvascular permeability in 515 sepsis The microcirculation is the motor of sepsis Severe abnormalities in microvascular perfused vessel density are associated 520 to organ dysfunctions and mortality and can be predicted by hyperlactatemia and 521 norepinephrine requirements in septic shock patients Microvascular resuscitation as a therapeutic goal in 523 severe sepsis 525 Early difference in tissue pH and microvascular hemodynamics in hemorrhagic shock 526 resuscitation using polyethylene glycol-albumin-and hydroxyethyl starch-based plasma 527 expanders B. & Intaglietta, M. Microcirculation: Its Significance in Clinical and Molecular Microcirculation: Physiology, Pathophysiology, and 532 Clinical Application Clinical review: Clinical imaging of the 534 sublingual microcirculation in the critically ill -where do we stand? LPS/TLR4 signal transduction pathway Animal Models of sepsis: setting the stage Sustained release nitric oxide releasing nanoparticles: characterization of a novel 542 delivery platform based on nitrite containing hydrogel/glass composites A nanoparticle delivery vehicle for S-nitroso-N-acetyl cysteine: 546 Sustained vascular response 548 Sustained release nitric oxide from long-lived circulating nanoparticles. Medical care costs related to sepsis treatment add up to 68 approximately $20 billion in the United States.


id: cord-348785-f67amppy
author: Kapicibaşi, Hasan Oğuz
date: 2020-07-13
extension: .txt
mime: text/plain
words: 2697
sentence: 106
flesch: 41
cache: cache/cord-348785-f67amppy.txt
txt: txt/cord-348785-f67amppy.txt
title:
  Pulmonary effects of ozone therapy at different doses combined with antibioticotherapy in experimental sepsis model

summary:
  Pharmacology and toxicology of ozonetherapy today Oxygen-ozone immunoceutical therapy in COVID-19 outbreak: facts and figures Toxicity and biochemical mechanisms of ozone Gaseous ozone treatment inactivates Listeria innocua in vitro Efficacy of hyperbaric oxygen therapy and medical ozone therapy in experimental acute necrotizing pancreatitis Repetitive pneumoperitoneum with ozonized oxygen as a preventive in lethal polymicrobial sepsis in rats Pulmonary effects of ozone therapy at different doses combined with antibioticotherapy in experimental sepsis model IL-33 drives augmented responses to ozone in obese mice γδ T cells are required for M2 macrophage polarization and resolution of ozone-induced pulmonary inflammation in mice Role of neutralizing anti-murine interleukin-17A monoclonal antibody on chronic ozone-induced airway inflammation in mice Çakır et al. 32 reported the systemic inflammatory response markers of TNF-alpha and IL-1B levels reduced after ozone treatment.


id: cord-028164-yn53209z
author: Abe, Toshikazu
date: 2020-06-30
extension: .txt
mime: text/plain
words: 3095
sentence: 155
flesch: 50
cache: cache/cord-028164-yn53209z.txt
txt: txt/cord-028164-yn53209z.txt
title:
  Epidemiology of sepsis and septic shock in intensive care units between sepsis-2 and sepsis-3 populations: sepsis prognostication in intensive care unit and emergency room (SPICE-ICU)

summary:
  Table 1 shows characteristics of patients with infection in ICUs according to sepsis definitions. The trend in pathogens and antibiotics according to sepsis definitions was also nonspecific; however, blood culture positivity was lower if patients did not meet any definitions (sepsis-2 or sepsis-3), and carbapenem was more frequently used in patients who met any definitions (Table 2) .


id: cord-302379-jh6jxwyn
author: Jevon, Phil
title: Management of odontogenic infections and sepsis: an update
date: 2020-09-25
extension: .txt
mime: text/plain
words: 3426
sentence: 176
flesch: 45
cache: cache/cord-302379-jh6jxwyn.txt
txt: txt/cord-302379-jh6jxwyn.txt
summary:
  A retrospective study of 110 patients Deep neck abscesseschanging trends Life-threatening oro-facial infections Peterson's principles of oral and maxillofacial surgery Deep space neck infection: principles of surgical management Prescribing in Dental Practice Increasing frequency and severity of odontogenic infection requiring hospital admission and surgical management Ludwig's angina Ludwig's angina Management of head and neck infections in the immunocompromised patient Organ reserve, excess metabolic capacity, and aging Influence of Aging and Environment on Presentation of Infection in Older Adults Criteria for admission of odontogenic infections at high risk of deep neck space infection Irrigating drains for severe odontogenic infections do not improve outcome Antibiotic selection in head and neck infections Pharmacology of Local Anaesthetics Used in Oral Surgery Is conservative treatment of deep neck space infections appropriate? Evaluation of bacterial spectrum of orofacial infections and their antibiotic susceptibility Severe odontogenic infections. 14 Relying on antibiotics only in relieving dental infection is likely to be less effective and can cause antimicrobial resistance.


id: cord-001319-mlkaowqr
author: Giamarellos-Bourboulis, Evangelos J
title: Kinetics of circulating immunoglobulin M in sepsis: relationship with final outcome
date: 2013-10-21
extension: .txt
mime: text/plain
words: 3642
sentence: 147
flesch: 46
cache: cache/cord-001319-mlkaowqr.txt
txt: txt/cord-001319-mlkaowqr.txt
summary:
  From all these paired comparisons, significant changes of circulating IgM were found only between severe sepsis and septic shock; IgM was significantly decreased upon worsening from severe sepsis into septic shock (P = 0.039). Our findings lead to the hypothesis that during severe sepsis lymphocytes are hypofunctional for IgM production but high circulating IgM compensates for the patient's needs; once septic shock develops circulating IgM is fully consumed and lymphocytes are completely anergic for any IgM production.


id: cord-017337-vq3edhxn
author: Vincent, Jean-Louis
title: PIRO: The Key to Success?
date: 2009
extension: .txt
mime: text/plain
words: 3811
sentence: 134
flesch: 40
cache: cache/cord-017337-vq3edhxn.txt
txt: txt/cord-017337-vq3edhxn.txt
summary:
  Systemic infl ammatory response syndrome, sepsis, severe sepsis and septic shock: incidence, morbidities and outcomes in surgical ICU patients The Italian SEPSIS study: Preliminary results on the incidence and evolution of SIRS, sepsis, severe sepsis and septic shock Dear Sirs, I'm sorry to say that I don't like you SCCM/ESICM/ACCP/ATS/SIS International Sepsis Defi nitions Conference Measures, markers, and mediators: toward a staging system for clinical sepsis. In the Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trial [20] , patients with urinary tract infections as a source of severe sepsis had a 28-day all-cause mortality of 21% compared with patients with a pulmonary source of sepsis who had a mortality rate of 34% (p < .01).


id: cord-347833-b3yrxkt0
author: Ahlström, Björn
date: 2020-09-04
extension: .txt
mime: text/plain
words: 4346
sentence: 195
flesch: 50
cache: cache/cord-347833-b3yrxkt0.txt
txt: txt/cord-347833-b3yrxkt0.txt
title:
  A nationwide study of the long-term prevalence of dementia and its risk factors in the Swedish intensive care cohort

summary:
  Such an approach allows for an accurate assessment of comorbidities in general and pre ICU dementia in particular. The date of dementia diagnosis was the first occurrence of the condition in the NPR or the SveDem.


id: cord-103081-k7ev5qkn
author: Janosevic, Danielle
date: 2020-05-30
extension: .txt
mime: text/plain
words: 4512
sentence: 201
flesch: 49
cache: cache/cord-103081-k7ev5qkn.txt
txt: txt/cord-103081-k7ev5qkn.txt
title:
  The orchestrated cellular and molecular responses of the kidney to endotoxin define the sepsis timeline

summary:
  In fact, four hours after LPS administration, 155 cluster-specific GO terms were indistinguishable among the majority of cell types with 156 enrichment in terms related to defense, immune and bacterium responses (Fig. 5b) . Single cell RNA sequencing revealed the involvement of various cell populations in injury and repair to be temporally organized and highly orchestrated.


id: cord-016127-tbot0fc9
author: Hurtado, F. J.
title: Sepsis: Clinical Approach, Evidence-Based at the Bedside
date: 2009-11-19
extension: .txt
mime: text/plain
words: 4879
sentence: 283
flesch: 42
cache: cache/cord-016127-tbot0fc9.txt
txt: txt/cord-016127-tbot0fc9.txt
summary:
  Since 2002 the Surviving Sepsis Campaign was introduced with the initial goal of increasing clinicians' awareness about severe sepsis mortality and to improve outcome in this patient population. Severe sepsis relates to the presence of sepsis and one or more related organ dysfunctions.


id: cord-015946-biu5zxd1
author: Peng, Daizhi
title: Research Advances in Biomarker for Sepsis
date: 2016-11-16
extension: .txt
mime: text/plain
words: 5102
sentence: 181
flesch: 32
cache: cache/cord-015946-biu5zxd1.txt
txt: txt/cord-015946-biu5zxd1.txt
summary:
  [71] found that miR-150 levels were significantly reduced in both leukocytes and plasma of sepsis patients and had a negative correlation with the level of disease severity measured by the Sequential Organ Failure Assessment (SOFA) score, which made it a biomarker of early sepsis. [72, 73] investigated the levels of miR-150 and miR-143 in peripheral blood leukocytes in sepsis patients with RT-PCR, and found that the expression levels of miR-150 and miR-143 were significantly decreased in sepsis patients and could reflect the severity of sepsis in certain degree, which not only made it a marker to reflect the situation of inflammatory response, but also made it a prognostic marker in sepsis.


id: cord-312197-d5d8amk7
author: Edmond, Karen
title: New Approaches to Preventing, Diagnosing, and Treating Neonatal Sepsis
date: 2010-03-09
extension: .txt
mime: text/plain
words: 5228
sentence: 232
flesch: 35
cache: cache/cord-312197-d5d8amk7.txt
txt: txt/cord-312197-d5d8amk7.txt
summary:
  key: cord-312197-d5d8amk7 authors: Edmond, Karen; Zaidi, Anita title: New Approaches to Preventing, Diagnosing, and Treating Neonatal Sepsis date: 2010-03-09 journal: PLoS Med DOI: 10.1371/journal.pmed.1000213 sha: doc_id: 312197 cord_uid: d5d8amk7 Karen Edmond and Anita Zaidi highlight new approaches that could reduce the burden of neonatal sepsis worldwide. Neonatal sepsis or septicaemia is a clinical syndrome characterized by systemic signs of circulatory compromise (e.g., poor peripheral perfusion, pallor, hypotonia, poor responsiveness) caused by invasion of the bloodstream by bacteria in the first month of life.


id: cord-252859-zir02q69
author: Chung, T. Philip
title: Molecular Diagnostics in Sepsis: From Bedside to Bench
date: 2006-09-11
extension: .txt
mime: text/plain
words: 5746
sentence: 232
flesch: 41
cache: cache/cord-252859-zir02q69.txt
txt: txt/cord-252859-zir02q69.txt
summary:
  Using mouse spleen samples for gene expression analysis, we were able to classify the samples as CLP or Sham with 96.0% accuracy, estimated using cross-validation. Because the clinical use of gene expression analysis using splenic tissue is severely limited, we explored next the use of circulating blood for class prediction in our mouse models.


id: cord-017420-tjwxec77
author: Stephens, R. Scott
title: Neutropenic Fever in the Intensive Care Unit
date: 2019-07-09
extension: .txt
mime: text/plain
words: 5866
sentence: 237
flesch: 29
cache: cache/cord-017420-tjwxec77.txt
txt: txt/cord-017420-tjwxec77.txt
summary:
  Bacteremia is documented in up to 25% of neutropenic fever patients [28] . The signs, symptoms and helpseeking experiences of neutropenic sepsis patients before they reach hospital: a qualitative study Risk Stratification of Sepsis, C. Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients Bronchoalveolar lavage during neutropenic episodes: diagnostic yield and cellular pattern Role of circulating lymphocytes in patients with sepsis Thrombocytopenia impairs host defense in gramnegative pneumonia-derived sepsis in mice Meta-analysis of randomized controlled trials of prophylactic granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor after autologous and allogeneic stem cell transplantation Blood platelets and sepsis pathophysiology: a new therapeutic prospect in critical ill patients?


id: cord-030385-btf502ju
author: Sun, Zhiheng
date: 2020-07-22
extension: .txt
mime: text/plain
words: 5878
sentence: 269
flesch: 52
cache: cache/cord-030385-btf502ju.txt
txt: txt/cord-030385-btf502ju.txt
title:
  17β-Estradiol Promotes Trained Immunity in Females Against Sepsis via Regulating Nucleus Translocation of RelB

summary:
  Shock Effects of gender on the severity of sepsis Sexual dimorphism in bacterial infections Gender differences in trauma, shock and sepsis Sex and severe sepsis NFkappaB is a key player in the crosstalk between inflammation and cardiovascular diseases Mutations in the estrogen receptor alpha hormone binding domain promote stem cell phenotype through notch activation in breast cancer cell lines NFkappaB affects estrogen receptor expression and activity in breast cancer through multiple mechanisms An additive interaction between the NFkappaB and estrogen receptor signalling pathways in human endometrial epithelial cells Despite inhibition of nuclear localization of NF-kappa B p65, c-Rel, and RelB, 17-beta estradiol up-regulates NF-kappa B signaling in mouse splenocytes: the potential role of Bcl-3 BCG-induced trained immunity in NK cells: role for non-specific protection to infection Trained immunity: a new avenue for tuberculosis vaccine development Targeting SHIP-1 in myeloid cells enhances trained immunity and boosts response to infection The impact of sex hormones on BCG-induced trained immunity mTOR-and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity Increased acetylation of H3K14 in the genomic regions that encode trained immunity enzymes in lysophosphatidylcholine-activated human aortic endothelial cells-novel qualification markers for chronic disease risk factors and conditional DAMPs Severe sepsis and septic shock Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care Trained immunity: a smart way to enhance innate immune defence Differential involvement of RelB in morphine-induced modulation of chemotaxis, NO, and cytokine production in murine macrophages and lymphocytes RelB regulation of chemokine expression modulates local inflammation RelB cellular regulation and transcriptional activity are regulated by p100 Year in review in Intensive Care Medicine, 2008. In order to examine the effect of estradiol on trained immunity, we decided to pre-treat the macrophage cell lines with estradiol before trained immunity model.


id: cord-261633-r4qlbnc5
author: Xie, Guo-Hao
title: Defensins and Sepsis
date: 2014-08-19
extension: .txt
mime: text/plain
words: 2928
sentence: 111
flesch: 35
cache: cache/cord-261633-r4qlbnc5.txt
txt: txt/cord-261633-r4qlbnc5.txt
summary:
  Sepsis, severe sepsis, and septic shock represent a continuum of clinical syndromes which are common complications observed in patients with infection, trauma, and major surgeries [1] [2] [3] . Epidemiology studies demonstrated that severe sepsis has a population prevalence of 300/100 000 in the United States and counts for 10-30% of the intensive care unit (ICU) patients [4] [5] [6] .


id: cord-005603-kjcbbgse
author: Brun-Buisson, C.
title: The epidemiology of the systemic inflammatory response
date: 2000
extension: .txt
mime: text/plain
words: 7183
sentence: 255
flesch: 44
cache: cache/cord-005603-kjcbbgse.txt
txt: txt/cord-005603-kjcbbgse.txt
summary:
  Severe sepsis and septic shock occur in 2 %–3 % of ward patients and 10 %–15 % or more ICU patients, depending on the case-mix; 25 % of patients with severe sepsis have shock. Severe sepsis and septic shock occur in 2 %±3 % of ward patients and 10 %±15 % or more ICU patients, depending on the case-mix; 25 % of patients with severe sepsis have shock.


id: cord-001293-dfaxj3bv
author: Cavaillon, Jean-Marc
title: Is boosting the immune system in sepsis appropriate?
date: 2014-03-24
extension: .txt
mime: text/plain
words: 6247
sentence: 235
flesch: 27
cache: cache/cord-001293-dfaxj3bv.txt
txt: txt/cord-001293-dfaxj3bv.txt
summary:
  The clinical observations used to argue that immunosuppression occurs in sepsis patients surviving the initial inflammatory cascade These are all organisms of normal virulence that cause nosocomial infections in sepsis patients because of the selection pressure of potent antibiotics and the presence of biofilm affected/colonized intravascular and urinary catheters.


id: cord-017376-wrhkfcff
author: Liu, Yongjian
title: Pro-resolution of Inflammation: New Hints to Manage Sepsis?
date: 2019-05-28
extension: .txt
mime: text/plain
words: 6250
sentence: 254
flesch: 31
cache: cache/cord-017376-wrhkfcff.txt
txt: txt/cord-017376-wrhkfcff.txt
summary:
  The inflammatory host response was long considered as a passive process, which is terminated by the clearance of pro-inflammatory mediators. These effects inhibit the infiltration of pro-inflammatory cells.


id: cord-018840-ts2g1ux7
author: Katragkou, Aspasia
title: Role of Immunoglobulin Therapy to Prevent and Treat Infections
date: 2018-06-19
extension: .txt
mime: text/plain
words: 6706
sentence: 255
flesch: 26
cache: cache/cord-018840-ts2g1ux7.txt
txt: txt/cord-018840-ts2g1ux7.txt
summary:
  Randomized trial in bone marrow transplant recipients Guidelines for the use of human immunoglobulin therapy in patients with primary immunodeficiencies in Latin America Some but not all benefits of intravenous immunoglobulin therapy after marrow transplantation appear to correlate with IgG trough levels A new paradigm for the treatment of sepsis: is it time to consider combination therapy? Primary immune deficiencies (PIDD) are one of the US Food and Drug Administration (FDA)approved indications for immunoglobulin therapy.


id: cord-298505-r7ihqb96
author: Górski, Andrzej
title: Sepsis, Phages, and COVID-19
date: 2020-10-15
extension: .txt
mime: text/plain
words: 3741
sentence: 169
flesch: 41
cache: cache/cord-298505-r7ihqb96.txt
txt: txt/cord-298505-r7ihqb96.txt
summary:
  Thus, clinical trials assessing the value of phage therapy in sepsis, including viral sepsis, are urgently needed. In this review, we summarize the progress in treating sepsis with phage therapy over the last three years.


id: cord-000522-d498qj2b
author: Vincent, Jean-Louis
title: Reducing mortality in sepsis: new directions
date: 2002-12-05
extension: .txt
mime: text/plain
words: 8718
sentence: 358
flesch: 43
cache: cache/cord-000522-d498qj2b.txt
txt: txt/cord-000522-d498qj2b.txt
summary:
  Interestingly, this decrease was apparent even before the five interventions discussed in the present article were published, reflecting improvements in the general supportive care of sepsis patients. Generalists have been taught to recognize the signs Sepsis patients often come 'second hand' from a and symptoms of AMI; initial treatment is usually specialist who may not be appropriately trained to provided by emergency physicians, who are trained diagnose, manage, and refer patients with sepsis to treat these patients Mortality prior to hospital discharge in patients receiving a tidal volume of 6 and 12 ml/kg ideal body weight.


id: cord-006460-3ayc0hne
author: Baue, Arthur E.
date: 2000-10-19
extension: .txt
mime: text/plain
words: 8385
sentence: 464
flesch: 53
cache: cache/cord-006460-3ayc0hne.txt
txt: txt/cord-006460-3ayc0hne.txt
title:
  Multiple organ failure – the discrepancy between our scientific knowledge and understanding and the management of our patients

summary:
  The three major reasons that I described earlier for the discrepancy between science and patient care also apply here. I have now reviewed the third reason for the discrepancy between excellent science and patient care.


id: cord-005872-w1x1i0im
author: Volk, T.
title: Endothelium function in sepsis
date: 2000
extension: .txt
mime: text/plain
words: 8880
sentence: 328
flesch: 21
cache: cache/cord-005872-w1x1i0im.txt
txt: txt/cord-005872-w1x1i0im.txt
summary:
  Endothelial cells lack CD14 receptors and LPS effects on endothelial cells generally require the presence of CD14 in the serum. Molecular analysis of a novel bidirectional pathway Two distinct phospholipases C of Listeria monocytogenes induce ceramide generation, nuclear factor-kappa acivation, and E-selectin expression in human endothelial cells Internalin B is essential for adhesion and mediates the invasion of Listeria monocytogenes into human endothelial cells Activation of human endothelial cells by viable or heat-killed gram-negative bacteria requires soluble CD14 Interaction of Neisseria maningitidis with the components of the blood-brain barrier correlates with an increased expression of PilC The Ndomain of the human CD66a adhesion molecule is a target for Opa proteins of Neisseria meningitidis and Neisseria gonorrhoeae Human microvascular endothelial tissue culture cell model for studying pathogenesis of Brazilian purpuric fever Pseudomonas aeruginosa selective adherence to and entry into human endothelial cells Endothelial function in sepsis 193 Cincomitant endosome-phagosome fusion and lysis of endosomal membranes account for Pseudomonas aeruginosa survival in human endothelial cells Endothelial cell GlcNAc beta 1-4GlcNAc epitopes for outer membrane protein A enhance traversal of Escherichia coli across the blood-brain barrier Escherichia coli invasion of brain microvascular endothelial cells in vitro and in vivo: molecular cloning and characterization of invasion gene ibe10 Characterization of a strain of Chlamydia pneumoniae isolated from a coronary atheroma by analysis of the omp1 gene and biological activity in human endothelial cells Chlamydia species infect human vascular endothelial cells and induce procoagulant activity Signal Transduction Pathways Activated in Endothelial Cells Following Infection with Chlamydia pneumoniae Bartonella (Rochalimaea) quintana endocarditis in three homeless men Bartonella quintana invades and multiplies within endothelial cells in vitro and in vivo and forms intracellular blebs Interaction of Bartonella henselae with endothelial cells results in bacterial aggregation on the cell surface and the subsequent engulfment and internalisation of the bacterial aggregate by a unique structure, the invasome NF-kappa B-dependent inhibition of apoptosis is essential for host cellsurvival during Rickettsia rickettsii infection Rickettsia conorii infection enhances vascular cell adhesion molecule-1-and intercellular adhesion molecule-1-dependent mononuclear cell adherence to endothelial cells IL-6 and IL-8 production from cultured human endothelial cells stimulated by infect on with Rickettsia conorii via a cell-associated IL-1 alpha-dependent pathway The role of CD14 in signaling mediated by outer membrane lipoproteins of Borrelia burgdorferi Integrins alpha(v)beta3 and alpha5beta1 mediate attachment of lyme disease spirochetes to human cells Different classes of proteoglycans contribute to the attachment of Borrelia burgdorferi to cultured endothelial and brain cells Borrelia burgdorferi upregulates the adhesion molecules E-selectin, P-selectin, ICAM-1 and VCAM-1 on mouse endothelioma cells in vitro Characterization of Plasmodium falciparum-infected erythrocyte and P-selectin interaction under flow conditions Intercellular adhesion molecule-1 and CD36 synergize to mediate adherence of Plasmodium falciparum-infected erythrocytes to cultured human microvascular endothelial cells PECAM-1/CD31, an endothelial receptor for binding Plasmodium falciparum-infected erythrocytes Candida albicans stimulates cytokine production and leukocyte adhesion molecule expression by endothelial cells Secreted aspartyl proteinases and interactions of Candida albicans with human endothelial cells Dengue virus infection of human endothelial cells leads to chemokine production, complement activation, and apoptosis Adhesion molecule expression and lymphocyte adhesion to cerebral endothelium: effects of measles virus and herpes simplex 1 virus Measles virus induction of human endothelial cell tissue factor procoagulant activity in vitro Effects of viral activation of the vessel wall on inflammation and thrombosis Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta3 integrins Ebola virus inhibits induction of genes by double-stranded RNA in endothelial cells Human endothelial cell activation and mediator release in response to the bacterial exotoxins Escherichia coli hemolysin and staphylococcal alpha-toxin Infection by verocytotoxin-producing Escherichia coli Alpha toxin from Clostridium perfringens induces proinflammatory changes in endothelial cells Brain capillary endothelial cells express MBEC1, a protein that is related to the Clostridium perfringens enterotoxin receptors Phospholipase C and perfringolysin O from Clostridium perfringens upregulate endothelial cellleukocyte adherence molecule 1 and intercellular leukocyte adherence molecule 1 expression and induce interleukin-8 synthesis in cultured human umbilical vein endothelial cells Glucosylation of small GTP-binding Rho proteins disrupts endothelial barrier function Pasteurella multocida toxin increases endothelial permeability via Rho kinase and myosin light chain phosphatase Evidence for a structural motif in toxins and interleukin-2 that may be responsible for binding to endothelial cells and initiating vascular leak syndrome The listerial exotoxins listeriolysin and phosphatidylinositol-specific phospholipase C synergize to elicit endothelial cell phosphoinositide metabolism Lipoteichoic acid-induced neutrophil adhesion via E-selectin to human umbilical vein endothelial cells (HUVECs) Endothelial and epithelial cells do not respond to complexes of peptidoglycan with soluble CD14 but are activated indirectly by peptidoglycan-induced tumor necrosis factor-alpha and interleukin-1 from monocytes Cytokines and endothelial cell biology Cytokine regulation of endothelial cell function: from molecular level to he bedside Pseudomonas siderophore pyochelin enhances neutrophil-mediated endothelial cell injury Superoxide dismutase-dependent, catalase-sensitive peroxides in human endothelial cells infected by Rickettsia rickettsii Superoxide release from interleukin-1B-stimulated human vascular cells: in situ electrochemical measuremeut Lipopolysaccharide enhances oxidative modification of low density lipoprotein by copper ions, endothelial and smooth muscle cells E-selectin expression in human endothelial cells by TNF-alpha-induced oxidant generation and NF-kappaB activation Superoxide responses of endothelial cells to C5a and TNF-alpha: divergent signal transduction pathways Lactosylceramide mediates tumor necrosis factor-alpha induced intercellular adhesion molecule-1 (ICAM-1) expression and the adhesion of neutrophil in human umbilical vein endothelial cells Effect of antioxidants on lipopolysaccharide-stimulated induction of mangano superoxide dismutase mRNA in bovine pulmonary artery endothelial cells Ambient but not incremental oxidant generation effects intercellular adhesion molecule 1 induction by tumour necrosis factor alpha in endothelium ICAM-1 and VCAM-1 expression induced by TNF-alpha are inhibited by a glutathione peroxidase mimic Glutathione peroxidase mimics prevent TNFalpha-and neutrophilinduced endothelial alterations Pore-forming bacterial toxins potently induce release of nitric oxide in porcine endothelial cells Cytokine-induced, nitric oxide-dependent, intracellular antirickettsial activity of mouse endothelial cells Endothelial cells are activated by cytokine treatment to kill an intravascular parasite, Schistosoma mansoni, through the production of nitric oxide Escherichia coli endotoxin inhibits agonistmediated cytosolic Ca2 + mobilization and nitric oxide biosynthesis in cultured endothelial cells Expressional control of the constitutive isoforms of nitric oxide synthase (NOS I and NOS III) Inducible nitric oxide: an autoregulatory feedback inhibitor of vascular inflammation Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide Nitric oxide donor prevents hydrogen peroxide-mediated endothelial cell injury Nitric oxide attenuates hydrogen peroxide-mediated injury to porcine pulmonary artery endothelial cells Protective effects of tetrahydrobiopterin against nitric oxide-induced endothelial cell death Endothelial damage induced by nitric oxide: synergism with reactive oxygen species Hydroxyl radical formation resulting from the interaction of nitric oxide and hydrogen peroxide Halliwell B van d V. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothelial cells Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation Lipopolysaccharide induces the antiapoptotic molecules, A1 and A20, in microvascular endothelial cells Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases Oxidant-sensitive and phosphorylation-dependent activation of NF-kappa B and AP-1 in endothelial cells Endothelial activation by hydrogen peroxide.


id: cord-002956-e5ihpe4i
author: Chang, Ya-Chun
date: 2018-04-04
extension: .txt
mime: text/plain
words: 4670
sentence: 211
flesch: 41
cache: cache/cord-002956-e5ihpe4i.txt
txt: txt/cord-002956-e5ihpe4i.txt
title:
  Ventilator Dependence Risk Score for the Prediction of Prolonged Mechanical Ventilation in Patients Who Survive Sepsis/Septic Shock with Respiratory Failure

summary:
  Ondine's curse: a clinical case and review Respiratory dysfunction in stroke Histone deacetylase 2 (HDAC2) attenuates lipopolysaccharide (LPS)-induced inflammation by regulating PAI-1 expression Beyond thrombosis: the versatile platelet in critical illness The role of platelets in sepsis Understanding platelet dysfunction in sepsis Metabolic acidosis in patients with severe sepsis and septic shock: a longitudinal quantitative study Breathing pattern in weaning patients: comparison of two inspired oxygen fractions Development and validation of immune dysfunction score to predict 28-day mortality of sepsis patients Immune profiles and clinical outcomes between sepsis patients with or without active cancer requiring admission to intensive care units Impact of clinical severity index, infective pathogens, and initial empiric antibiotic use on hospital mortality in patients with ventilator-associated pneumonia Predictors of prolonged weaning and survival during ventilator weaning in a respiratory ICU A prospective study of indexes predicting the outcome of trials of weaning from mechanical ventilation Association of day 4 cumulative fluid balance with mortality in critically ill patients with influenza: A multicenter retrospective cohort study in Taiwan Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: We also found the AUC of ventilator dependence risk score was 0.745 in the cancer group and p-value was 0.009.


id: cord-006426-baf2d47y
author: Kimura, Fumio
title: Immunosuppression following surgical and traumatic injury
date: 2010-08-26
extension: .txt
mime: text/plain
words: 9873
sentence: 413
flesch: 31
cache: cache/cord-006426-baf2d47y.txt
txt: txt/cord-006426-baf2d47y.txt
summary:
  An aggressive surgical approach leads to improved survival in patients with gallbladder cancer: a 12-year study at a North American Center Bacteremia after hepatectomy: an analysis of a singlecenter, 10-year experience with 407 patients Pancreaticoduodenectomy: a 20-year experience in 516 patients Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality Organ-preserving surgery for benign lesions and low-grade malignancies of the pancreatic head: a matched case-control study Surgical trauma and immunosuppression: pathophysiology and potential immunomodulatory approaches Cell response to surgery The immunological consequences of injury Systemic infl ammation after trauma Immunologic dissonance: a continuing evolution in our understanding of the systemic infl ammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS) Evolving concepts in the pathogenesis of postinjury multiple organ failure The early second hit in trauma management augments the proinfl ammatory immune response to multiple injuries Interleukin-6 in the injured patient. Therefore, even in the absence of pathogens, disrupted or injured cells recruit innate infl ammatory cells by releasing DAMPs.


id: cord-005569-9d51l6bn
author: Antonelli, Massimo
date: 2008-12-09
extension: .txt
mime: text/plain
words: 10277
sentence: 443
flesch: 36
cache: cache/cord-005569-9d51l6bn.txt
txt: txt/cord-005569-9d51l6bn.txt
title:
  Year in review in Intensive Care Medicine, 2008: I. Brain injury and neurology, renal failure and endocrinology, metabolism and nutrition, sepsis, infections and pneumonia

summary:
  Entropy of the frontal EEG does not discriminate sedation state adequately for clinical use in ICU patients. The cumulated energy deficit in ICU patients primarily on enteral nutrition, which has been reported in several studies, is mainly related to underfeeding during the initial week of ICU stay.


id: cord-302295-nblmshni
author: Savva, Athina
date: 2013-11-18
extension: .txt
mime: text/plain
words: 10341
sentence: 356
flesch: 30
cache: cache/cord-302295-nblmshni.txt
txt: txt/cord-302295-nblmshni.txt
title:
  Targeting Toll-Like Receptors: Promising Therapeutic Strategies for the Management of Sepsis-Associated Pathology and Infectious Diseases

summary:
  Prophylactic administration of anti-TLR4 antibodies blunted TNF production and strikingly increased survival in E. coli sepsis, from 0% in the control antibody group to 80% in the anti-TLR4 group. Our studies demonstrate that anti-TLR4 antibodies are efficient as adjunctive therapy for E. coli sepsis, with a window of clinical application comprising prophylactic and therapeutic intervention opportunities.


id: cord-297039-vfuem6bk
author: Beltrán-García, Jesús
title: Circular RNAs in Sepsis: Biogenesis, Function, and Clinical Significance
date: 2020-06-25
extension: .txt
mime: text/plain
words: 7510
sentence: 276
flesch: 35
cache: cache/cord-297039-vfuem6bk.txt
txt: txt/cord-297039-vfuem6bk.txt
summary:
  The novel roles of circular RNAs in metabolic organs Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection Cytokine storm and sepsis disease pathogenesis Another Road to Sepsis and Its Therapeutic Targeting Modulation of TNF-α mRNA stability by human antigen R and miR181s in sepsis-induced immunoparalysis miRNA-125b regulates TNF-α production in CD14+ neonatal monocytes via post-transcriptional regulation Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1 Multiplex cytokine profiling in patients with sepsis Dysregulation in microRNA expression in peripheral blood mononuclear cells of sepsis patients is associated with immunopathology Attenuation of Cardiac Dysfunction in Polymicrobial Sepsis by MicroRNA-146a Is Mediated via Targeting of IRAK1 and TRAF6 Expression Toll-like receptor-mediated NF-kappaB activation: A phylogenetically conserved paradigm in innate immunity A human homologue of the Drosophila Toll protein signals activation of adaptive immunity Elevation of IL-18 in human sepsis IL-18) levels in patients with sepsis IL-27 Enhances LPS-Induced Proinflammatory Cytokine Production via Upregulation of TLR4 Expression and Signaling in Human Monocytes IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells Circular RNA circ-4099 is induced by TNF-α and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration Follow-up study identifies two novel susceptibility loci PRKCB and 8p11.21 for systemic lupus erythematosus Calcitonin gene-related peptide induces IL-6 expression in RAW264.7 macrophages mediated by mmu_circRNA_007893 CircRNA hsa_circ_0005105 upregulates NAMPT expression and promotes chondrocyte extracellular matrix degradation by sponging miR-26a The down-regulation of hsa_circ_0012919, the sponge for miR-125a-3p, contributes to DNA methylation of CD11a and CD70 in CD4+ T cells of systemic lupus erythematous Persistent inflammation and immunosuppression: A common syndrome and new horizon for surgical intensive care MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development MicroRNA control in the immune system: BBasic principles MicroRNA miR-223 as regulator of innate immunity Impact of miR-223-3p and miR-2909 on inflammatory factors IL-6, IL-1ß, and TNF-α, and the TLR4/TLR2/NF-κB/STAT3 signaling pathway induced by lipopolysaccharide in human adipose stem cells Hsa_circ_0003159 inhibits gastric cancer progression by regulating miR-223-3p/NDRG1 axis Serum miR-146a and miR-223 as potential new biomarkers for sepsis NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses The prognostic value of plasma microRNA-155 and microRNA-146a level in severe sepsis and sepsis-induced acute lung injury patients Circular RNA RSF1 promotes inflammatory and fibrotic phenotypes of irradiated hepatic stellate cell by modulating miR-146a-5p Circular RNA expression alterations in colon tissues of Crohn's disease patients Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer MiR-125b but not miR-125a is upregulated and exhibits a trend to correlate with enhanced disease severity, inflammation, and increased mortality in sepsis patients Circular RNA GLI2 promotes osteosarcoma cell proliferation, migration, and invasion by targeting miR-125b-5p Circulating plasma microRNAs can differentiate human sepsis and Systemic Inflammatory Response Syndrome (SIRS) NSD2 circular RNA promotes metastasis of colorectal cancer by targeting miR-199b-5p-mediated DDR1 and JAG1 signalling Circular RNA 0000096 affects cell growth and migration in gastric cancer Circular RNA circHIPK3 Promotes the Proliferation and Differentiation of Chicken Myoblast Cells by Sponging miR-30a-3p Circular RNA Signature in Hepatocellular Carcinoma CircRNA-9119 regulates the expression of prostaglandin-endoperoxide synthase 2 (PTGS2) by sponging miR-26a in the endometrial epithelial cells of dairy goat Circular RNA circTRIM33-12 acts as the sponge of MicroRNA-191 to suppress hepatocellular carcinoma progression Sepsis: Older and newer concepts Circular RNA circ-Foxo3 induced cell apoptosis in urothelial carcinoma via interaction with miR-191-5p Basophil Recruitment to Skin Lesions of Patients with Systemic Lupus Erythematosus Mediated by CCR1 and CCR2 Sepsis definitions: Time for change The Clinical Challenge of Sepsis Identification and Monitoring Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock Early versus delayed administration of norepinephrine in patients with septic shock Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: Results from a guideline-based performance improvement program Diagnostic and prognostic markers in sepsis New approaches to sepsis: Molecular diagnostics and biomarkers MiR-145 negatively regulates TGFBR2 signaling responsible for sepsis-induced acute lung injury Function and clinical significance of circRNAs in solid tumors Matrix-metalloproteinases and their inhibitors are elevated in severe sepsis: Prognostic value of TIMP-1 in severe sepsis Matrix metalloproteinase-14 triggers an anti-inflammatory proteolytic cascade in endotoxemia Predictive value of miRNA-29a and miRNA-10a-5p for 28-day mortality in patients with sepsis-induced acute kidney injury.


id: cord-354384-bshj0w3o
author: Tanak, Ambalika S.
date: 2020-10-19
extension: .txt
mime: text/plain
words: 6723
sentence: 237
flesch: 38
cache: cache/cord-354384-bshj0w3o.txt
txt: txt/cord-354384-bshj0w3o.txt
title:
  Multiplexed cytokine detection using electrochemical point-of-care sensing device towards rapid sepsis endotyping

summary:
  DETecT Sepsis sensor provides a descriptive understanding of the host immune response with the pentaplex biomarker strategy enabling patient stratification to predict timely evidence on the arc of sepsis. DETecT Sepsis sensor can be used effectively in the emergency department for early sepsis screening, or it can be used to monitor sepsis prognosis for patients as a bedside monitoring device.


id: cord-349076-x3rjasg0
author: Jarczak, Dominik
title: Use of Intravenous Immunoglobulins in Sepsis Therapy—A Clinical View
date: 2020-08-03
extension: .txt
mime: text/plain
words: 7030
sentence: 254
flesch: 30
cache: cache/cord-349076-x3rjasg0.txt
txt: txt/cord-349076-x3rjasg0.txt
summary:
  Impact of neutrophil and organism age on neutrophil extracellular trap formation Neutrophil extracellular traps in sepsis A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma Myeloid-derived suppressor cells coming of age Intravenous immunoglobulins-understanding properties and mechanisms Innate response activator B cells: Origins and functions Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis An extended leukocyte differential count (16 types of circulating leukocytes) using the cytodiff flow cytometric system can provide informations for the discrimination of sepsis severity and prediction of outcome in sepsis patients Early alterations of B cells in patients with septic shock Alterations of B Cells in Immunosuppressive Phase of Septic Shock Patients Reduced circulating B cells and plasma IgM levels are associated with decreased survival in sepsis-A meta-analysis Early levels in blood of immunoglobulin M and natural killer cells predict outcome in nonseptic critically ill patients Bench-to-bedside review: Immunoglobulin therapy for sepsis-biological plausibility from a critical care perspective Can Concurrent Abnormalities in Free Light Chains and Immunoglobulin Concentrations Identify a Target Population for Immunoglobulin Trials in Sepsis? Nevertheless, the Surviving Sepsis Campaign (SSC) guidelines suggested against IVIg use in sepsis therapy 2016 due to lack of sufficient evidence of efficacy for preparations containing only IgG


id: cord-023935-o2ffxgnn
author: Lorts, Angela
title: Sepsis
date: 2011-12-16
extension: .txt
mime: text/plain
words: 11116
sentence: 437
flesch: 34
cache: cache/cord-023935-o2ffxgnn.txt
txt: txt/cord-023935-o2ffxgnn.txt
summary:
  More recently, a polymorphism within the CD14 promoter gene (C to T transition at base pair -159) was identifi ed with a particular genotype over-represented among septic shock patients compared to healthy controls. It is believed that genetic differences among hosts are at least in part responsible for this variability in sepsis responses.


id: cord-017470-sjk7a34u
author: Arlati, Sergio
title: Pathophysiology of Acute Illness and Injury
date: 2018-06-14
extension: .txt
mime: text/plain
words: 16318
sentence: 756
flesch: 30
cache: cache/cord-017470-sjk7a34u.txt
txt: txt/cord-017470-sjk7a34u.txt
summary:
  The endothelium is a key factor for production of remote organ damage as it exerts potent chemo-attracting effects on inflammatory cells, allows for leukocyte trafficking into tissues and organs, and promotes further inflammation by cytokines release. Induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55 Inflammatory cytokines and cell response in surgery Cox G IL6 is an anti-inflammatory cytokine required for controlling local or systemic acute inflammatory responses Procalcitonin as a diagnostic marker and IL-6 as a prognostic marker for sepsis Interleukin-6 levels act as a diagnostic marker for infection and a prognostic marker in patients with organ dysfunction in the intensive care unit Interleukin 6 is a useful marker for early prediction of the severity of acute pancreatitis Chemokine signaling in inflammation Complement activation in injured patients occurs immediately and is dependent on the severity of the trauma The role of the complement system in traumatic brain injury Femur fracture induces site-specific changes in T-cells immunity Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement Innate autoimmunity Natural antibodies, autoantibodies and complement activation in tissue injury Role of biological modifiers regulating the immune response after trauma The role of neuroinflammation in traumatic brain injury Evidence for a role of kallikrein-kinin system in patients with shock after blunt trauma Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases Platelets: bridging hemostasis, inflammation and immunity Coagulation abnormalities in acute lung injury and sepsis Priming for enhanced alveolar fibrin deposition after hemorrhagic shock: role for tumor necrosis factor New treatment strategies for disseminated intravascular coagulation based on current understanding of the pathophysiology Systemic inflammation and disseminated intravascular coagulation in early stage of ALI and ARDS: role of neutrophil and endothelial activation Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinases


id: cord-015082-l629n8is
title: Poster Sessions 323-461
date: 2002-08-29
extension: .txt
mime: text/plain
words: 26609
sentence: 1451
flesch: 50
cache: cache/cord-015082-l629n8is.txt
txt: txt/cord-015082-l629n8is.txt
summary:
  Isoflurane sedation of ICU patients has previously been shown to be useful but has not come into wide clinical use for a number of reasons. Isoflurane administered via the ACD for sedation of ICU patients is environmentally safe, requires small volumes of isoflurane and may provide better quality of sedation than midazolam.


id: cord-022592-g7rmzsv5
author: Wynn, James L.
title: Pathophysiology of Neonatal Sepsis
date: 2016-07-06
extension: .txt
mime: text/plain
words: 22168
sentence: 853
flesch: 30
cache: cache/cord-022592-g7rmzsv5.txt
txt: txt/cord-022592-g7rmzsv5.txt
summary:
  The expression of surface tissue factor apoprotein by blood monocytes in the course of infections in early infancy Complement and coagulation: strangers or partners in crime? Indications of coagulation and/ or fibrinolytic system activation in healthy and sick very-low-birth-weight neonates Coagulation, fibrinolytic and kallikrein systems in neonates with uncomplicated sepsis and septic shock Plasma antithrombin III and protein C levels in early recognition of late-onset sepsis in newborns Study of protein C, protein S, and antithrombin III in newborns with sepsis Low plasma protein C values predict mortality in low birth weight neonates with septicemia Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial The tissue factor and plasminogen activator inhibitor type-1 response in pediatric sepsis-induced multiple organ failure Evaluation and treatment of thrombocytopenia in the neonatal intensive care unit Low immature platelet fraction suggests decreased megakaryopoiesis in neonates with sepsis or necrotizing enterocolitis Whole blood platelet deposition on extracellular matrix under flow conditions in preterm neonatal sepsis The platelet hyporeactivity of extremely low birth weight neonates is age-dependent The Ashwell receptor mitigates the lethal coagulopathy of sepsis Platelet count and sepsis in very low birth weight neonates: is there an organism-specific response? Disseminated intravascular coagulation in the newborn Natural history of neonatal herpes simplex virus infections in the acyclovir era Protease-activated receptor-1: key player in the sepsis coagulation-inflammation crosstalk Increased numbers of macrophages in tracheal aspirates in premature infants with funisitis Neutrophil-derived microparticles induce myeloperoxidase-mediated damage of vascular endothelial cells Coagulation dysfunction in sepsis and multiple organ system failure Endothelial glucocorticoid receptor is required for protection against sepsis Admission angiopoietin levels in children with septic shock Group B streptococcal beta-hemolysin promotes injury of lung microvascular endothelial cells Pathophysiologic mechanisms of persistent pulmonary hypertension of the newborn Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice Correlation between susceptibility of infants to infections and interaction with neutrophils of Escherichia coli strains causing neonatal and infantile septicemia Innate cellular immune responses in newborns Impact of prematurity, stress and sepsis on the neutrophil respiratory burst activity of neonates Functional analysis of neutrophil granulocytes from healthy, infected, and stressed neonates Decreased bactericidal activity of leukocytes of stressed newborn infants Spontaneous and Fas-mediated apoptosis are diminished in umbilical cord blood neutrophils compared with adult neutrophils Mechanisms underlying reduced apoptosis in neonatal neutrophils Neonatal neutrophils with prolonged survival exhibit enhanced inflammatory and cytotoxic responsiveness Neutrophil extracellular traps kill bacteria Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus Neutrophil-derived circulating free DNA (cf-DNA/NETs): a potential prognostic marker for posttraumatic development of inflammatory second hit and sepsis Novel cell death program leads to neutrophil extracellular traps Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates Delayed but functional neutrophil extracellular trap formation in neonates Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens Outcomes following candiduria in extremely low birth weight infants Exhaustion of mature marrow neutrophils in neonates with sepsis Neutrophil storage pool depletion in neonates with sepsis and neutropenia Evaluation of risk factors for fatal neonatal sepsis Can neutrophil responses in very low birth weight infants predict the organisms responsible for late-onset bacterial or fungal sepsis? Neonatal sepsis has been inconsistently defined on the basis of a variety of clinical and laboratory criteria, which makes the study of this condition very difficult.


id: cord-020643-0yzkqykg
author: Müller-Werdan, U.
title: Schock
date: 2006
extension: .txt
mime: text/plain
words: 30700
sentence: 1764
flesch: 35
cache: cache/cord-020643-0yzkqykg.txt
txt: txt/cord-020643-0yzkqykg.txt
summary:
  6.6.4 Traumatischer Schock -419 6.6.5 Anaphylaktischer Schock -419 Die Reduktion der effektiven Gewebeperfusion kann dabei hervorgerufen werden durch eine Abnahme der Herzleistung, durch Störungen der Makro-und Mikrozirkulation mit verminderter Perfusion, durch eine kritische Abnahme des Blutvolumens, eine Beeinträchtigung der O 2 -Aufnahme in der Lunge und der O 2 -Abgabe Noch ausstehend ist der Nachweis der klinischen Wirksamkeit einer Antioxidanzientherapie (Mullan u. McCloskey 2002) , der in zahlreichen Studien für folgende Substanzen nicht erbracht werden konnte: Superoxiddismutase, Katalase, Glutathionperoxidase, Ascorbinsäure, Glutathion, Harnsäure, α-Tocopherol, Karotinoide, der Xanthinoxidasehemmer Allopurinol, Lazaroide, Pyruvat (Fink 2003) , der Hemmung der Komplementaktivierung (Ciurana u. Hack 2002) , von PARP-Inhibitoren (Szabó u. Liaudet 2002; Liaudet et al. 2001 ) oder der Inhibition der MAP-Kinasen (Tulleken et al. 2001 ).


id: cord-015024-2xzc0uc5
title: ESICM 2010 WEDNESDAY SESSIONS 13 October 2010
date: 2010-08-31
extension: .txt
mime: text/plain
words: 84465
sentence: 4517
flesch: 50
cache: cache/cord-015024-2xzc0uc5.txt
txt: txt/cord-015024-2xzc0uc5.txt
summary:
  The primary end point of this study was to evaluate the RVD of the IVC in ICU patients with spontaneous breathing. ICU patient with spontaneous breathing and signs of hypoperfusion (oliguria, mottles, serum lactate level [2 mmol/l) were eligible after the approval of the local Ethics Committee.


id: cord-014996-p6q0f37c
title: Posters_Monday_12 October 2009
date: 2009-08-06
extension: .txt
mime: text/plain
words: 85276
sentence: 4622
flesch: 51
cache: cache/cord-014996-p6q0f37c.txt
txt: txt/cord-014996-p6q0f37c.txt
summary:
  ICU patients with acute respiratory failure requiring NIV were studied during three randomized consecutive 20 min-periods of NIV: ICU ventilator with and without NIV mode and NIV ventilator. EFL was recorded in 65% of ICU patients with pulmonary diseases: 65 % of ARDS patients, 75% of patients with respiratory infection, 75% of asthmatics and 85% of patients with COPD.


id: cord-005497-w81ysjf9
date: 2020-03-24
extension: .txt
mime: text/plain
words: 103795
sentence: 5338
flesch: 50
cache: cache/cord-005497-w81ysjf9.txt
txt: txt/cord-005497-w81ysjf9.txt
title:
  40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020

summary:
  Conclusions: This is one of the first studies to demonstrate that abnormal RV function is associated with an increased mortality in ICU patients with pneumonia. The fast efficacy of targeted therapies led some intensivists to use them as rescue therapy for ICU patients.


id: cord-015021-pol2qm74
date: 1994
extension: .txt
mime: text/plain
words: 162543
sentence: 7248
flesch: 45
cache: cache/cord-015021-pol2qm74.txt
txt: txt/cord-015021-pol2qm74.txt
title:
  Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches

summary:
  Ever since we know the role of endotoxins in the pathophysiology of sepsis, antibodies against the S-and R-LPS have also been detected in sepsis patients. In sepsis patients, the CD]4+/CD16+ cells can become a major population with more than 50% of all monocytes in 3 of 18 patients and with more than 500 cells/mm 3 in 4 of 18 cases.


# ent

id: cord-018284-grvj99eh
sid: 9
eid: 2
type: ORG
entity:
  beeinflussung der gerinnung fahr der/des mods/mov und störung der makrozirkulation aufgrund einer reduzierten kardialen pumpfunktion


id: cord-018284-grvj99eh
sid: 10
eid: 3
type: ORG
entity:
  störung der fibrinolyse und thrombenbildung aufgrund einer fehlenden thrombin-thrombomodulin-stimulation


id: cord-020643-0yzkqykg
sid: 27
eid: 3
type: ORG
entity:
  gehirndurchblutung mit gleichzeitiger bewusstlosigkeit wird als synkope bezeichnet (task force on syncope


id: cord-020643-0yzkqykg
sid: 46
eid: 1
type: PERSON
entity:
  prognostisch ungünstige faktoren beim hypovolämischen schock sind die geschwindigkeit des auftretens des volumenverlustes


id: cord-020643-0yzkqykg
sid: 69
eid: 6
type: PERSON
entity:
  rhythmusstörungen sowie traumatisch bedingte myokardkontusionen und intoxikationen mit negativ-inotropen


id: cord-020643-0yzkqykg
sid: 75
eid: 1
type: ORG
entity:
  bei einer akuten lungenembolie ohne vorbestehende kardiopulmonale erkrankung führt der verschluss von 2


id: cord-020643-0yzkqykg
sid: 75
eid: 6
type: PERSON
entity:
  werden teilweise wesentlich höhere anteile an lungenstrombettverschlüssen ohne schocksymptomatik toleriert


id: cord-020643-0yzkqykg
sid: 124
eid: 3
type: ORG
entity:
  unverträglichkeitsreaktionen ohne vorausgehende sensibilisierung mit einem sehr ähnlichen oder identischen klinischen erscheinungsbild


id: cord-020643-0yzkqykg
sid: 178
eid: 2
type: ORG
entity:
  oberen atemwege kommt es oft zu einer pulmonalen überblähung oder auch zu einer ausgeprägten bronchokonstriktion


id: cord-020643-0yzkqykg
sid: 179
eid: 1
type: ORG
entity:
  der neurogene schock wird durch einen verlust der peripheren vasomotorenkontrolle infolge einer dysfunktion oder einer verletzung des nervensystems hervorgerufen


id: cord-020643-0yzkqykg
sid: 183
eid: 1
type: PERSON
entity:
  eine -allerdings selbstlimitierende und vorübergehende -neurale fehlregulation fi ndet sich auch als ursache der vasovagalen synkope


id: cord-020643-0yzkqykg
sid: 210
eid: 1
type: PERSON
entity:
  erst bei einer ausgeprägten kontraktilitätsminderung wird diese als einschränkung des herzauswurfs manifest


id: cord-020643-0yzkqykg
sid: 216
eid: 2
type: ORG
entity:
  wird durch den tonus der präkapillären arteriolen und prä-und postkapillären sphinktergefäße sowie durch lokale


id: cord-020643-0yzkqykg
sid: 229
eid: 6
type: ORG
entity:
  beruht auf einer sepsisinduzierten aktiven vasodilatation und dem verlust der extrinsischen vasomotorenkontrolle


id: cord-020643-0yzkqykg
sid: 231
eid: 4
type: FAC
entity:
  den anderen organen und demzufolge ist die koronarperfusion bei patienten mit septischem schock sogar häufi g erhöht


id: cord-020643-0yzkqykg
sid: 308
eid: 1
type: ORG
entity:
  können zur proteolytischen spaltung der tnf-rezeptoren und ihrer freisetzung als lösliche tnf-rezeptoren


id: cord-020643-0yzkqykg
sid: 349
eid: 2
type: ORG
entity:
  rnos) -insbesondere das aus dem stickoxid-und dem superoxidradikal entstehende peroxinitritradikal -wirken


id: cord-020643-0yzkqykg
sid: 370
eid: 1
type: PERSON
entity:
  der anp-anstieg korreliert dabei mehr mit dem il-6-anstieg und weniger mit der kardiovaskuären dysfunktion


id: cord-020643-0yzkqykg
sid: 469
eid: 6
type: PERSON
entity:
  eine abschätzung der linksventrikulären vorlast kann damit nicht ausreichend sicher durchgeführt werden


id: cord-020643-0yzkqykg
sid: 484
eid: 1
type: PERSON
entity:
  kurze perioden einer ausgeprägten minderperfusion werden besser toleriert als gravierende blutdruckabfälle


id: cord-020643-0yzkqykg
sid: 508
eid: 1
type: ORG
entity:
  eines adrenalinrefraktären schocks infolge kammerfl immerns bei erwachsenen gilt vasopressin als klasse-iia-empfehlung


id: cord-020643-0yzkqykg
sid: 516
eid: 1
type: ORG
entity:
  amiodaron wird empfohlen bei persistenz von kammertachykardie oder kammerfl immern nach defi brillation und adrenalingabe


id: cord-020643-0yzkqykg
sid: 542
eid: 2
type: ORG
entity:
  nach defi brillation mit nachfolgender asystolie konnte dadurch der ausgang der prähospitalen kardiopulmonalen


id: cord-020643-0yzkqykg
sid: 569
eid: 1
type: ORG
entity:
  anhebung des extrazellulären ph-werts mit bikarbonat führt nicht immer zum gewünschten erfolg des intrazellulären ph-anstiegs


id: cord-020643-0yzkqykg
sid: 586
eid: 3
type: ORG
entity:
  sie erhöht neben dem volumen des extrazellulärraums unerwünschterweise auch das des intrazellulärraums


id: cord-020643-0yzkqykg
sid: 632
eid: 7
type: PERSON
entity:
  verbunden mit einem anstieg des extravaskulären kod und damit der gefahr der ausbildung oder verstärkung eines lungenödems


id: cord-020643-0yzkqykg
sid: 633
eid: 2
type: ORG
entity:
  der organperfusion sind weder für kristalloide noch für kolloidale lösungen bei der volumensubstitution


id: cord-020643-0yzkqykg
sid: 677
eid: 7
type: PERSON
entity:
  den kardiogenen noch für den septischen schock gibt es hinsichtlich einer möglichen letalitätssenkung evidenzbasierte daten!


id: cord-020643-0yzkqykg
sid: 685
eid: 1
type: ORG
entity:
  bei der volumensubstitution des septischen schocks mit dobutamin können deshalb größere flüssigkeitsmengen erforderlich werden als im


id: cord-020643-0yzkqykg
sid: 686
eid: 1
type: ORG
entity:
  dobutamin ist das katecholamin der wahl zur therapie der eingeschränkten pumpfunktion der septischen kardiomyopathie


id: cord-020643-0yzkqykg
sid: 698
eid: 1
type: PERSON
entity:
  über den erfolgreichen einsatz von β-rezeptorenblockern zur verbesserung der katecholaminansprechbarkeit wurde bisher beim


id: cord-020643-0yzkqykg
sid: 710
eid: 3
type: PERSON
entity:
  > gegen ist es bei tachykardem vorhoffl immern und vorhoffl attern zur frequenznormalisierung bei schockpatienten das antiarrhythmikum der wahl


id: cord-020643-0yzkqykg
sid: 735
eid: 5
type: PERSON
entity:
  bei der behandlung einer unkontrollierbaren intraabdominellen blutung zu einer verbesserung der überlebensrate führt.


id: cord-020643-0yzkqykg
sid: 746
eid: 1
type: ORG
entity:
  der kardiogene schock führt häufi g zu lungenstauung/lungenödem und zum prärenalen nierenversagen und damit zur oligurie


id: cord-020643-0yzkqykg
sid: 778
eid: 1
type: PERSON
entity:
  diese hypothese geht von der darmwandtranslokation von bakterien und endotoxinen als mods-ursache aus.


id: cord-020643-0yzkqykg
sid: 812
eid: 2
type: ORG
entity:
  zum unkomplizierten postoperativen verlauf -überschießende systemische entzündungsreaktion infolge des operationstraumas und des einsatzes des kardiopulmonalen bypass


id: cord-020643-0yzkqykg
sid: 818
eid: 1
type: PERSON
entity:
  aufgrund der gestörten barrierefunktion kann auch kein nennenswerter osmotischer druckgradient aufgebaut werden


id: cord-020643-0yzkqykg
sid: 819
eid: 1
type: ORG
entity:
  störung der barrierefunktion des endothels wird nach gegenwärtiger auffassung durch mediatoren ausgelöst


id: cord-020643-0yzkqykg
sid: 820
eid: 1
type: ORG
entity:
  uniformität der pulmonalen reaktion bei sehr unterschiedlichen klinischen ausgangskonstellationen wird dabei > auf


id: cord-020643-0yzkqykg
sid: 853
eid: 2
type: PERSON
entity:
  obwohl eine vorübergehende kreislaufstabilisierung -messbar als anstieg des systemischen gefäßwiderstandes -beschrieben ist (hoffmann et al


id: cord-020643-0yzkqykg
sid: 866
eid: 1
type: ORG
entity:
  diese hochgradige renale vasokonstriktion bei leberschädigung wird durch eine aktivierung des renin-angiotensin-aldosteron-systems


id: cord-020643-0yzkqykg
sid: 894
eid: 2
type: ORG
entity:
  eingeschränkten klinisch-neurologischen beurteilung eines intensivpatienten kommt den elektrophysiologischen


id: cord-020643-0yzkqykg
sid: 894
eid: 8
type: ORG
entity:
  der liquorpunktion und gelegentlich der kernspintomographie eine große diagnostische und differenzialdiagnostische bedeutung zu.


id: cord-020643-0yzkqykg
sid: 919
eid: 2
type: ORG
entity:
  minderversorgung mit oxygeniertem blut als folge von minderperfusion oder hypoxie wird ein schleimhautschädigender circulus vitiosus


id: cord-020643-0yzkqykg
sid: 942
eid: 1
type: PERSON
entity:
  auch nach erfolgreicher schockbehandlung kann die biliäre stase mit erhöhten werten für bilirubin und alkalische


id: cord-020643-0yzkqykg
sid: 954
eid: 10
type: ORG
entity:
  während der zunehmende schweregrad des multiorganversagens zur irreversiblen thrombozytendegranulierung führt


id: cord-020643-0yzkqykg
sid: 954
eid: 12
type: ORG
entity:
  der verstärkten oberfl ächenexpression der thrombozytenadhäsionsmoleküle gmp-140 und thrombospondin mit zunehmendem


id: cord-020643-0yzkqykg
sid: 993
eid: 5
type: PERSON
entity:
  über verschiedenene mechanismen kann es im septischen schock zu einer relativen nebennierenrindeninsuffi zienz kommen


id: cord-020643-0yzkqykg
sid: 995
eid: 1
type: ORG
entity:
  ansprechens des kreislaufs auf vasopressorische katecholamine und wahrscheinlich auch eine erhöhte sterblichkeit


id: cord-020643-0yzkqykg
sid: 1011
eid: 3
type: PERSON
entity:
  schock ist folge einer komplexen schädigung des humoralen und zellulären immunsystems bei schock und sirs


id: cord-020643-0yzkqykg
sid: 1037
eid: 3
type: PERSON
entity:
  dagegen ist es bei tachykardem vorhoffl immern und vorhoffl attern zur frequenznormalisierung das antiarrhythmikum der


id: cord-020643-0yzkqykg
sid: 1060
eid: 1
type: ORG
entity:
  wiederherstellung einer suffi zienten koronarperfusion bis hin zu mehr oder weniger komplexen kreislaufunterstützungssystemen


id: cord-020643-0yzkqykg
sid: 1090
eid: 1
type: ORG
entity:
  der vorteilhafte effekt der intraaortalen gegenpulsation im zusammenhang mit perkutaner revaskularisation


id: cord-020643-0yzkqykg
sid: 1111
eid: 4
type: PERSON
entity:
  soll dieses verfahren mit einer gewissen aussicht auf erfolg eingesetzt werden und nicht nur den irreversiblen


id: cord-020643-0yzkqykg
sid: 1135
eid: 4
type: ORG
entity:
  den vergangenen jahren die dokumentierte infarktsterblichkeit seit der einführung der intensivüberwachung


id: cord-020643-0yzkqykg
sid: 1155
eid: 2
type: PERSON
entity:
  ein eindeutiger behandlungsvorteil zu gunsten der mechanischen koronarrevaskularisiation gegenüber der thrombolyse


id: cord-020643-0yzkqykg
sid: 1171
eid: 1
type: ORG
entity:
  effektivität des glykoproteinrezeptorantagonisten abciximab konnte sowohl bei perkutanen koronarhochri


id: cord-020643-0yzkqykg
sid: 1238
eid: 2
type: ORG
entity:
  inoperabilität eines patienten mit dekompensierter aortenklappenstenose und schock kann auf der intensivstation bei sorgfältigem invasivem hämodynamischem


id: cord-020643-0yzkqykg
sid: 1251
eid: 6
type: PERSON
entity:
  als folge davon kommt es zur aktivierung von blutzellen mit freisetzung von aggressiven mediatoren und proinfl ammatorischen zytokinen


id: cord-020643-0yzkqykg
sid: 1260
eid: 1
type: PERSON
entity:
  prinzipiell denkbare effekte auf koronarien und myokard scheinen nicht sehr ausgeprägt bis fehlend zu sein


id: cord-020643-0yzkqykg
sid: 1283
eid: 2
type: ORG
entity:
  mit massivem blutdruckabfall könnte ein gesundes herz durch einen drastischen anstieg des herzzeitvolumens kompensieren


id: cord-020643-0yzkqykg
sid: 1310
eid: 2
type: ORG
entity:
  sepsispatienten sind durch ein absolutes und ein relatives intravasales volumendefi zit charakterisiert


id: cord-020643-0yzkqykg
sid: 1426
eid: 1
type: ORG
entity:
  hämodynamischen veränderungen des anaphylaktischen schocks sind aus kasuistischen beschreibungen bekannt (hanashiro u weil 1967


id: cord-020643-0yzkqykg
sid: 1527
eid: 12
type: ORG
entity:
  der prähospitalen und hospitalen schockbehandlung -hyperton-onkotische lösungen und vasopressin severe


