item: #1 of 45 id: cord-000522-d498qj2b author: Vincent, Jean-Louis title: Reducing mortality in sepsis: new directions date: 2002-12-05 words: 8718 flesch: 43 summary: Interestingly, this decrease was apparent even before the five interventions discussed in the present article were published, reflecting improvements in the general supportive care of sepsis patients. Generalists have been taught to recognize the signs Sepsis patients often come 'second hand' from a and symptoms of AMI; initial treatment is usually specialist who may not be appropriately trained to provided by emergency physicians, who are trained diagnose, manage, and refer patients with sepsis to treat these patients Mortality prior to hospital discharge in patients receiving a tidal volume of 6 and 12 ml/kg ideal body weight. keywords: alfa; care; drotrecogin; group; icu; interventions; mortality; patients; protein; sepsis; shock; study; therapy; treatment; trial cache: cord-000522-d498qj2b.txt plain text: cord-000522-d498qj2b.txt item: #2 of 45 id: cord-001293-dfaxj3bv author: Cavaillon, Jean-Marc title: Is boosting the immune system in sepsis appropriate? date: 2014-03-24 words: 6247 flesch: 27 summary: The clinical observations used to argue that immunosuppression occurs in sepsis patients surviving the initial inflammatory cascade These are all organisms of normal virulence that cause nosocomial infections in sepsis patients because of the selection pressure of potent antibiotics and the presence of biofilm affected/colonized intravascular and urinary catheters. keywords: apoptosis; cells; cytokine; expression; immune; infection; mice; model; murine; patients; production; response; sepsis; tnf cache: cord-001293-dfaxj3bv.txt plain text: cord-001293-dfaxj3bv.txt item: #3 of 45 id: cord-001319-mlkaowqr author: Giamarellos-Bourboulis, Evangelos J title: Kinetics of circulating immunoglobulin M in sepsis: relationship with final outcome date: 2013-10-21 words: 3642 flesch: 46 summary: From all these paired comparisons, significant changes of circulating IgM were found only between severe sepsis and septic shock; IgM was significantly decreased upon worsening from severe sepsis into septic shock (P = 0.039). Our findings lead to the hypothesis that during severe sepsis lymphocytes are hypofunctional for IgM production but high circulating IgM compensates for the patient's needs; once septic shock develops circulating IgM is fully consumed and lymphocytes are completely anergic for any IgM production. keywords: blood; cells; igm; patients; production; sepsis; shock; study; survivors cache: cord-001319-mlkaowqr.txt plain text: cord-001319-mlkaowqr.txt item: #4 of 45 id: cord-002956-e5ihpe4i author: Chang, Ya-Chun title: Ventilator Dependence Risk Score for the Prediction of Prolonged Mechanical Ventilation in Patients Who Survive Sepsis/Septic Shock with Respiratory Failure date: 2018-04-04 words: 4670 flesch: 41 summary: Ondine's curse: a clinical case and review Respiratory dysfunction in stroke Histone deacetylase 2 (HDAC2) attenuates lipopolysaccharide (LPS)-induced inflammation by regulating PAI-1 expression Beyond thrombosis: the versatile platelet in critical illness The role of platelets in sepsis Understanding platelet dysfunction in sepsis Metabolic acidosis in patients with severe sepsis and septic shock: a longitudinal quantitative study Breathing pattern in weaning patients: comparison of two inspired oxygen fractions Development and validation of immune dysfunction score to predict 28-day mortality of sepsis patients Immune profiles and clinical outcomes between sepsis patients with or without active cancer requiring admission to intensive care units Impact of clinical severity index, infective pathogens, and initial empiric antibiotic use on hospital mortality in patients with ventilator-associated pneumonia Predictors of prolonged weaning and survival during ventilator weaning in a respiratory ICU A prospective study of indexes predicting the outcome of trials of weaning from mechanical ventilation Association of day 4 cumulative fluid balance with mortality in critically ill patients with influenza: A multicenter retrospective cohort study in Taiwan Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: We also found the AUC of ventilator dependence risk score was 0.745 in the cancer group and p-value was 0.009. keywords: day; dependence; patients; risk; score; sepsis; study; ventilator; ventilator dependence cache: cord-002956-e5ihpe4i.txt plain text: cord-002956-e5ihpe4i.txt item: #5 of 45 id: cord-005497-w81ysjf9 author: None title: 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date: 2020-03-24 words: 103795 flesch: 50 summary: Conclusions: This is one of the first studies to demonstrate that abnormal RV function is associated with an increased mortality in ICU patients with pneumonia. The fast efficacy of targeted therapies led some intensivists to use them as rescue therapy for ICU patients. keywords: acute; administration; admission; adult patients; age; aim; aki; aki patients; analysis; approach; arrest; arterial; associated; association; average; baseline; blood; cardiac; care; care patients; care unit; cases; clinical; cohort; cohort study; complications; control; critical; critical care; data; day mortality; days; death; delirium; difference; discharge; disease; early; ecmo; effect; emergency; factors; failure; figure; fluid; function; group; hospital; hospital mortality; hours; icu admission; icu mortality; icu patients; icu stay; ill; incidence; increase; index; infection; injury; intensive; introduction; length; levels; low; lps; lung; management; mean; median; medical; methods; min; model; months; mortality; non; number; observational; organ; outcome; pain; parameters; patients; period; plasma; population; positive; post; pressure; rate; renal; results; risk; score; sepsis; sepsis patients; septic; serum; shock; shock patients; sofa; stay; studies; study; support; surgery; survival; table; test; therapy; time; total; treatment; unit; university; use; value; ventilation; volume; years cache: cord-005497-w81ysjf9.txt plain text: cord-005497-w81ysjf9.txt item: #6 of 45 id: cord-005569-9d51l6bn author: Antonelli, Massimo title: Year in review in Intensive Care Medicine, 2008: I. Brain injury and neurology, renal failure and endocrinology, metabolism and nutrition, sepsis, infections and pneumonia date: 2008-12-09 words: 10277 flesch: 36 summary: Entropy of the frontal EEG does not discriminate sedation state adequately for clinical use in ICU patients. The cumulated energy deficit in ICU patients primarily on enteral nutrition, which has been reported in several studies, is mainly related to underfeeding during the initial week of ICU stay. keywords: acute; authors; care; control; delirium; glucose; icp; icu; infection; intensive; levels; monitoring; mortality; non; outcome; patients; sepsis; shock; study; therapy cache: cord-005569-9d51l6bn.txt plain text: cord-005569-9d51l6bn.txt item: #7 of 45 id: cord-005603-kjcbbgse author: Brun-Buisson, C. title: The epidemiology of the systemic inflammatory response date: 2000 words: 7183 flesch: 44 summary: Severe sepsis and septic shock occur in 2 %–3 % of ward patients and 10 %–15 % or more ICU patients, depending on the case-mix; 25 % of patients with severe sepsis have shock. Severe sepsis and septic shock occur in 2 %±3 % of ward patients and 10 %±15 % or more ICU patients, depending on the case-mix; 25 % of patients with severe sepsis have shock. keywords: icu; infection; mortality; patients; sepsis; septic; shock; sirs; study cache: cord-005603-kjcbbgse.txt plain text: cord-005603-kjcbbgse.txt item: #8 of 45 id: cord-005697-l1zmrq4p author: Pène, Frédéric title: Is this critically ill patient immunocompromised? date: 2015-12-02 words: 1346 flesch: 21 summary: Timing and causes of death in septic shock Genetic influences on incidence and case-fatality of infectious disease Epigenetic programming of monocyteto-macrophage differentiation and trained innate immunity The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia Specific MAIT cell behaviour among innate-like T lymphocytes in critically ill patients with severe infections Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy Reactivation of multiple viruses in patients with sepsis Innate immune dysfunction in trauma patients: from pathophysiology to treatment Temporary withdrawal of immunosuppression for life-threatening infections after liver transplantation Monocytic HLA-DR expression in intensive care patients: interest for prognosis and secondary infection prediction Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebocontrolled multicenter trial Elevated plasmatic level of soluble IL-7 receptor is associated with increased mortality in septic shock patients Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock IL-7 restores lymphocyte functions in septic patients Case series and small trials indicate that immunostimulating compounds are able to restore immune function and may exert beneficial clinical effects in sepsis patients, while no overt safety issues have been reported [12, 13] . keywords: infections; patients; response; sepsis cache: cord-005697-l1zmrq4p.txt plain text: cord-005697-l1zmrq4p.txt item: #9 of 45 id: cord-005872-w1x1i0im author: Volk, T. title: Endothelium function in sepsis date: 2000 words: 8880 flesch: 21 summary: Endothelial cells lack CD14 receptors and LPS effects on endothelial cells generally require the presence of CD14 in the serum. Molecular analysis of a novel bidirectional pathway Two distinct phospholipases C of Listeria monocytogenes induce ceramide generation, nuclear factor-kappa acivation, and E-selectin expression in human endothelial cells Internalin B is essential for adhesion and mediates the invasion of Listeria monocytogenes into human endothelial cells Activation of human endothelial cells by viable or heat-killed gram-negative bacteria requires soluble CD14 Interaction of Neisseria maningitidis with the components of the blood-brain barrier correlates with an increased expression of PilC The Ndomain of the human CD66a adhesion molecule is a target for Opa proteins of Neisseria meningitidis and Neisseria gonorrhoeae Human microvascular endothelial tissue culture cell model for studying pathogenesis of Brazilian purpuric fever Pseudomonas aeruginosa selective adherence to and entry into human endothelial cells Endothelial function in sepsis 193 Cincomitant endosome-phagosome fusion and lysis of endosomal membranes account for Pseudomonas aeruginosa survival in human endothelial cells Endothelial cell GlcNAc beta 1-4GlcNAc epitopes for outer membrane protein A enhance traversal of Escherichia coli across the blood-brain barrier Escherichia coli invasion of brain microvascular endothelial cells in vitro and in vivo: molecular cloning and characterization of invasion gene ibe10 Characterization of a strain of Chlamydia pneumoniae isolated from a coronary atheroma by analysis of the omp1 gene and biological activity in human endothelial cells Chlamydia species infect human vascular endothelial cells and induce procoagulant activity Signal Transduction Pathways Activated in Endothelial Cells Following Infection with Chlamydia pneumoniae Bartonella (Rochalimaea) quintana endocarditis in three homeless men Bartonella quintana invades and multiplies within endothelial cells in vitro and in vivo and forms intracellular blebs Interaction of Bartonella henselae with endothelial cells results in bacterial aggregation on the cell surface and the subsequent engulfment and internalisation of the bacterial aggregate by a unique structure, the invasome NF-kappa B-dependent inhibition of apoptosis is essential for host cellsurvival during Rickettsia rickettsii infection Rickettsia conorii infection enhances vascular cell adhesion molecule-1-and intercellular adhesion molecule-1-dependent mononuclear cell adherence to endothelial cells IL-6 and IL-8 production from cultured human endothelial cells stimulated by infect on with Rickettsia conorii via a cell-associated IL-1 alpha-dependent pathway The role of CD14 in signaling mediated by outer membrane lipoproteins of Borrelia burgdorferi Integrins alpha(v)beta3 and alpha5beta1 mediate attachment of lyme disease spirochetes to human cells Different classes of proteoglycans contribute to the attachment of Borrelia burgdorferi to cultured endothelial and brain cells Borrelia burgdorferi upregulates the adhesion molecules E-selectin, P-selectin, ICAM-1 and VCAM-1 on mouse endothelioma cells in vitro Characterization of Plasmodium falciparum-infected erythrocyte and P-selectin interaction under flow conditions Intercellular adhesion molecule-1 and CD36 synergize to mediate adherence of Plasmodium falciparum-infected erythrocytes to cultured human microvascular endothelial cells PECAM-1/CD31, an endothelial receptor for binding Plasmodium falciparum-infected erythrocytes Candida albicans stimulates cytokine production and leukocyte adhesion molecule expression by endothelial cells Secreted aspartyl proteinases and interactions of Candida albicans with human endothelial cells Dengue virus infection of human endothelial cells leads to chemokine production, complement activation, and apoptosis Adhesion molecule expression and lymphocyte adhesion to cerebral endothelium: effects of measles virus and herpes simplex 1 virus Measles virus induction of human endothelial cell tissue factor procoagulant activity in vitro Effects of viral activation of the vessel wall on inflammation and thrombosis Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta3 integrins Ebola virus inhibits induction of genes by double-stranded RNA in endothelial cells Human endothelial cell activation and mediator release in response to the bacterial exotoxins Escherichia coli hemolysin and staphylococcal alpha-toxin Infection by verocytotoxin-producing Escherichia coli Alpha toxin from Clostridium perfringens induces proinflammatory changes in endothelial cells Brain capillary endothelial cells express MBEC1, a protein that is related to the Clostridium perfringens enterotoxin receptors Phospholipase C and perfringolysin O from Clostridium perfringens upregulate endothelial cellleukocyte adherence molecule 1 and intercellular leukocyte adherence molecule 1 expression and induce interleukin-8 synthesis in cultured human umbilical vein endothelial cells Glucosylation of small GTP-binding Rho proteins disrupts endothelial barrier function Pasteurella multocida toxin increases endothelial permeability via Rho kinase and myosin light chain phosphatase Evidence for a structural motif in toxins and interleukin-2 that may be responsible for binding to endothelial cells and initiating vascular leak syndrome The listerial exotoxins listeriolysin and phosphatidylinositol-specific phospholipase C synergize to elicit endothelial cell phosphoinositide metabolism Lipoteichoic acid-induced neutrophil adhesion via E-selectin to human umbilical vein endothelial cells (HUVECs) Endothelial and epithelial cells do not respond to complexes of peptidoglycan with soluble CD14 but are activated indirectly by peptidoglycan-induced tumor necrosis factor-alpha and interleukin-1 from monocytes Cytokines and endothelial cell biology Cytokine regulation of endothelial cell function: from molecular level to he bedside Pseudomonas siderophore pyochelin enhances neutrophil-mediated endothelial cell injury Superoxide dismutase-dependent, catalase-sensitive peroxides in human endothelial cells infected by Rickettsia rickettsii Superoxide release from interleukin-1B-stimulated human vascular cells: in situ electrochemical measuremeut Lipopolysaccharide enhances oxidative modification of low density lipoprotein by copper ions, endothelial and smooth muscle cells E-selectin expression in human endothelial cells by TNF-alpha-induced oxidant generation and NF-kappaB activation Superoxide responses of endothelial cells to C5a and TNF-alpha: divergent signal transduction pathways Lactosylceramide mediates tumor necrosis factor-alpha induced intercellular adhesion molecule-1 (ICAM-1) expression and the adhesion of neutrophil in human umbilical vein endothelial cells Effect of antioxidants on lipopolysaccharide-stimulated induction of mangano superoxide dismutase mRNA in bovine pulmonary artery endothelial cells Ambient but not incremental oxidant generation effects intercellular adhesion molecule 1 induction by tumour necrosis factor alpha in endothelium ICAM-1 and VCAM-1 expression induced by TNF-alpha are inhibited by a glutathione peroxidase mimic Glutathione peroxidase mimics prevent TNFalpha-and neutrophilinduced endothelial alterations Pore-forming bacterial toxins potently induce release of nitric oxide in porcine endothelial cells Cytokine-induced, nitric oxide-dependent, intracellular antirickettsial activity of mouse endothelial cells Endothelial cells are activated by cytokine treatment to kill an intravascular parasite, Schistosoma mansoni, through the production of nitric oxide Escherichia coli endotoxin inhibits agonistmediated cytosolic Ca2 + mobilization and nitric oxide biosynthesis in cultured endothelial cells Expressional control of the constitutive isoforms of nitric oxide synthase (NOS I and NOS III) Inducible nitric oxide: an autoregulatory feedback inhibitor of vascular inflammation Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide Nitric oxide donor prevents hydrogen peroxide-mediated endothelial cell injury Nitric oxide attenuates hydrogen peroxide-mediated injury to porcine pulmonary artery endothelial cells Protective effects of tetrahydrobiopterin against nitric oxide-induced endothelial cell death Endothelial damage induced by nitric oxide: synergism with reactive oxygen species Hydroxyl radical formation resulting from the interaction of nitric oxide and hydrogen peroxide Halliwell B van d V. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothelial cells Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation Lipopolysaccharide induces the antiapoptotic molecules, A1 and A20, in microvascular endothelial cells Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases Oxidant-sensitive and phosphorylation-dependent activation of NF-kappa B and AP-1 in endothelial cells Endothelial activation by hydrogen peroxide. keywords: activation; adhesion; alpha; cells; endothelial; expression; factor; function; human; infection; lps; microvascular; nitric; oxide; patients; permeability; production; relaxation; selectin; sepsis; shock; tnf cache: cord-005872-w1x1i0im.txt plain text: cord-005872-w1x1i0im.txt item: #10 of 45 id: cord-006414-60lpjg09 author: Engelmann, L. title: Die Diagnose der Sepsis date: 2006 words: 1299 flesch: 34 summary: Patienten mit Inflammationreaktion septischer und nicht-septischer Genese unterscheiden sich nicht im CRP-Verlauf (Abb. 4), während bei gesicherter Sepsis dem CRP-Verhalten eine prognostische Bedeutung zukommt (Abb. 5; [41, 50] ) Die Inflammationsreaktion ist eine weitestgehend uniforme Reaktion des Organismus auf Schädigung. key: cord-006414-60lpjg09 authors: Engelmann, L. title: Die Diagnose der Sepsis date: 2006 journal: Intensivmed Notfallmed DOI: 10.1007/s00390-006-0741-y sha: doc_id: 6414 cord_uid: 60lpjg09 The early diagnosis of sepsis is mandatory for the further reduction of mortality due to sepsis. keywords: das; der; die; ist; pct; procalcitonin; sepsis; serum; und cache: cord-006414-60lpjg09.txt plain text: cord-006414-60lpjg09.txt item: #11 of 45 id: cord-006426-baf2d47y author: Kimura, Fumio title: Immunosuppression following surgical and traumatic injury date: 2010-08-26 words: 9873 flesch: 31 summary: An aggressive surgical approach leads to improved survival in patients with gallbladder cancer: a 12-year study at a North American Center Bacteremia after hepatectomy: an analysis of a singlecenter, 10-year experience with 407 patients Pancreaticoduodenectomy: a 20-year experience in 516 patients Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality Organ-preserving surgery for benign lesions and low-grade malignancies of the pancreatic head: a matched case-control study Surgical trauma and immunosuppression: pathophysiology and potential immunomodulatory approaches Cell response to surgery The immunological consequences of injury Systemic infl ammation after trauma Immunologic dissonance: a continuing evolution in our understanding of the systemic infl ammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS) Evolving concepts in the pathogenesis of postinjury multiple organ failure The early second hit in trauma management augments the proinfl ammatory immune response to multiple injuries Interleukin-6 in the injured patient. Therefore, even in the absence of pathogens, disrupted or injured cells recruit innate infl ammatory cells by releasing DAMPs. keywords: activation; ammatory; associated; cells; expression; infection; infl; injury; levels; macrophages; monocytes; patients; receptors; response; role; sepsis; septic; shock; surgery; trauma cache: cord-006426-baf2d47y.txt plain text: cord-006426-baf2d47y.txt item: #12 of 45 id: cord-006460-3ayc0hne author: Baue, Arthur E. title: Multiple organ failure – the discrepancy between our scientific knowledge and understanding and the management of our patients date: 2000-10-19 words: 8385 flesch: 53 summary: The three major reasons that I described earlier for the discrepancy between science and patient care also apply here. I have now reviewed the third reason for the discrepancy between excellent science and patient care. keywords: care; differences; disease; failure; mof; mortality; organ; patients; response; sepsis; shock; sirs; syndrome; time; trauma; treatment cache: cord-006460-3ayc0hne.txt plain text: cord-006460-3ayc0hne.txt item: #13 of 45 id: cord-014658-oeuvelb1 author: Martin, Greg S. title: Optimal fluid management in sepsis date: 2019-11-07 words: 889 flesch: 41 summary: Albumin may be considered for administration to sepsis patients with refractory shock or who have received substantial amounts of crystalloid fluids, but should not be administered to patients with severe traumatic brain injury.(5) Albumin may be considered for administration to sepsis patients with refractory shock or who have received substantial amounts of crystalloid fluids, but should not be administered to patients with severe traumatic brain injury. keywords: patients; sepsis cache: cord-014658-oeuvelb1.txt plain text: cord-014658-oeuvelb1.txt item: #14 of 45 id: cord-014996-p6q0f37c author: None title: Posters_Monday_12 October 2009 date: 2009-08-06 words: 85276 flesch: 51 summary: ICU patients with acute respiratory failure requiring NIV were studied during three randomized consecutive 20 min-periods of NIV: ICU ventilator with and without NIV mode and NIV ventilator. EFL was recorded in 65% of ICU patients with pulmonary diseases: 65 % of ARDS patients, 75% of patients with respiratory infection, 75% of asthmatics and 85% of patients with COPD. keywords: acute; admission; adult patients; age; aim; analysis; apache; arterial; blood; cardiac; care; care patients; conclusion; control; data; days; diagnosis; differences; duration; early; failure; fluid; group; high; hospital; hospital mortality; icu; icu admission; icu mortality; icu patients; icu stay; incidence; infection; injury; intensive; introduction; lactate; length; levels; low; lung; mean; median; medical; methods; min; model; mortality; n =; non; number; objectives; organ; outcome; oxygen; p =; parameters; patients; pct; period; pneumonia; pressure; pulmonary; rate; renal; respiratory; results; risk; score; sepsis; septic; serum; shock; shock patients; stay; study; surgery; system; test; therapy; time; total; trauma patients; treatment; unit; use; vap; ventilation; volume; years cache: cord-014996-p6q0f37c.txt plain text: cord-014996-p6q0f37c.txt item: #15 of 45 id: cord-015021-pol2qm74 author: None title: Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date: 1994 words: 162543 flesch: 45 summary: Ever since we know the role of endotoxins in the pathophysiology of sepsis, antibodies against the S-and R-LPS have also been detected in sepsis patients. In sepsis patients, the CD]4+/CD16+ cells can become a major population with more than 50% of all monocytes in 3 of 18 patients and with more than 500 cells/mm 3 in 4 of 18 cases. keywords: acid; activation; activity; acute; addition; adhesion; administration; aim; analysis; animals; anti; antibodies; antibody; ards; arterial; bacteria; binding; blood; blood cells; blood levels; blood samples; body; burn; capacity; cardiac; cause; cd14; cells; cellular; challenge; changes; circulating; clinical; clp; complement; complications; concentrations; conclusion; conditions; contrast; control; control group; control patients; correlation; course; csf; cultured; cytokine levels; cytokine production; cytokines; damage; data; days; death; decrease; development; differences; disease; dose; dysfunction; effect; elevated; elisa; endothelial; endotoxin; endotoxin levels; evidence; experimental; expression; factor; failure; flow; following; formation; function; gene; gram; group; growth; gut; hepatic; high; host; hours; hrs; human; il-1; il-6; il-6 levels; il-8; ill; immune; increased; induction; infection; inflammation; inflammatory; infusion; inhibitor; injury; ischemia; leukocytes; levels; lipid; liver; lps; lung; lymphocytes; macrophages; mean; mechanisms; mediators; membrane; methods; mice; model; mof; molecules; monoclonal; monocytes; mortality; multiple; necrosis; negative; neutrophils; new; non; normal; number; operation; organ; organ failure; organ injury; outcome; oxygen; p<0.05; parameters; patients; period; peritoneal; phase; placebo; plasma; plasma levels; plasma tnf; play; pmn; positive; post; postoperative; potential; presence; present; pressure; process; production; protein; pulmonary; rate; rats; receptor; reduced; related; release; reperfusion; response; results; risk; role; saline; samples; score; sepsis; sepsis patients; septic; serum; serum levels; severity; sham; shock; sirs; soluble; specific; state; stimulation; studies; study; surface; surgery; survival; syndrome; synthesis; system; systemic; t cells; test; therapeutic; therapy; time; tissue; tnf; tnf levels; tnf production; tnf release; total; trauma patients; treated; treatment; tumor; type; use; values; vascular; vitro; vivo; wound cache: cord-015021-pol2qm74.txt plain text: cord-015021-pol2qm74.txt item: #16 of 45 id: cord-015024-2xzc0uc5 author: None title: ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date: 2010-08-31 words: 84465 flesch: 50 summary: The primary end point of this study was to evaluate the RVD of the IVC in ICU patients with spontaneous breathing. ICU patient with spontaneous breathing and signs of hypoperfusion (oliguria, mottles, serum lactate level [2 mmol/l) were eligible after the approval of the local Ethics Committee. keywords: acute; administration; admission; age; aim; analysis; apache; baseline; blood; cardiac; care; care patients; care unit; changes; clinical; conclusions; control; critical; data; day; days; death; difference; discharge; dose; effect; factors; failure; fluid; following; function; group; hemodynamic; high; hospital; icu admission; icu patients; incidence; increase; infusion; injury; intensive; introduction; levels; low; lung; management; mean; median; medical; methods; min; months; mortality; n =; non; number; nurses; objectives; outcome; p =; parameters; patients; period; plasma; post; pressure; pulmonary; rate; response; results; resuscitation; risk; score; sepsis; septic; serum; shock; shock patients; stay; study; support; surgery; test; therapy; time; total; treatment; unit; use; values; ventilation; volume; years cache: cord-015024-2xzc0uc5.txt plain text: cord-015024-2xzc0uc5.txt item: #17 of 45 id: cord-015082-l629n8is author: None title: Poster Sessions 323-461 date: 2002-08-29 words: 26609 flesch: 50 summary: Isoflurane sedation of ICU patients has previously been shown to be useful but has not come into wide clinical use for a number of reasons. Isoflurane administered via the ACD for sedation of ICU patients is environmentally safe, requires small volumes of isoflurane and may provide better quality of sedation than midazolam. keywords: acute; admission; age; analysis; blood; cardiac; care; complications; control; data; days; effect; group; hospital; hours; icu; increase; injury; levels; mean; methods; min; mortality; outcome; patients; postoperative; pressure; protein; rate; rats; response; results; score; sepsis; septic; shock; stay; study; surgery; test; time; trauma; treatment; years cache: cord-015082-l629n8is.txt plain text: cord-015082-l629n8is.txt item: #18 of 45 id: cord-015946-biu5zxd1 author: Peng, Daizhi title: Research Advances in Biomarker for Sepsis date: 2016-11-16 words: 5102 flesch: 32 summary: [71] found that miR-150 levels were significantly reduced in both leukocytes and plasma of sepsis patients and had a negative correlation with the level of disease severity measured by the Sequential Organ Failure Assessment (SOFA) score, which made it a biomarker of early sepsis. [72, 73] investigated the levels of miR-150 and miR-143 in peripheral blood leukocytes in sepsis patients with RT-PCR, and found that the expression levels of miR-150 and miR-143 were significantly decreased in sepsis patients and could reflect the severity of sepsis in certain degree, which not only made it a marker to reflect the situation of inflammatory response, but also made it a prognostic marker in sepsis. keywords: biomarkers; cell; dna; expression; gene; infection; levels; patients; plasma; potential; protein; sepsis; serum cache: cord-015946-biu5zxd1.txt plain text: cord-015946-biu5zxd1.txt item: #19 of 45 id: cord-016127-tbot0fc9 author: Hurtado, F. J. title: Sepsis: Clinical Approach, Evidence-Based at the Bedside date: 2009-11-19 words: 4879 flesch: 42 summary: Since 2002 the Surviving Sepsis Campaign was introduced with the initial goal of increasing clinicians' awareness about severe sepsis mortality and to improve outcome in this patient population. Severe sepsis relates to the presence of sepsis and one or more related organ dysfunctions. keywords: dysfunction; evidence; failure; infection; mortality; organ; patients; resuscitation; sepsis; shock; therapy cache: cord-016127-tbot0fc9.txt plain text: cord-016127-tbot0fc9.txt item: #20 of 45 id: cord-017337-vq3edhxn author: Vincent, Jean-Louis title: PIRO: The Key to Success? date: 2009 words: 3811 flesch: 40 summary: Systemic infl ammatory response syndrome, sepsis, severe sepsis and septic shock: incidence, morbidities and outcomes in surgical ICU patients The Italian SEPSIS study: Preliminary results on the incidence and evolution of SIRS, sepsis, severe sepsis and septic shock Dear Sirs, I'm sorry to say that I don't like you SCCM/ESICM/ACCP/ATS/SIS International Sepsis Defi nitions Conference Measures, markers, and mediators: toward a staging system for clinical sepsis. In the Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trial [20] , patients with urinary tract infections as a source of severe sepsis had a 28-day all-cause mortality of 21% compared with patients with a pulmonary source of sepsis who had a mortality rate of 34% (p < .01). keywords: dysfunction; infection; mortality; organ; patients; piro; response; sepsis; system cache: cord-017337-vq3edhxn.txt plain text: cord-017337-vq3edhxn.txt item: #21 of 45 id: cord-017376-wrhkfcff author: Liu, Yongjian title: Pro-resolution of Inflammation: New Hints to Manage Sepsis? date: 2019-05-28 words: 6250 flesch: 31 summary: The inflammatory host response was long considered as a passive process, which is terminated by the clearance of pro-inflammatory mediators. These effects inhibit the infiltration of pro-inflammatory cells. keywords: acute; anti; aspirin; inflammation; lxa4; mediators; model; patients; pro; resolution; resolving; response; sepsis; survival cache: cord-017376-wrhkfcff.txt plain text: cord-017376-wrhkfcff.txt item: #22 of 45 id: cord-017420-tjwxec77 author: Stephens, R. Scott title: Neutropenic Fever in the Intensive Care Unit date: 2019-07-09 words: 5866 flesch: 29 summary: Bacteremia is documented in up to 25% of neutropenic fever patients [28] . The signs, symptoms and helpseeking experiences of neutropenic sepsis patients before they reach hospital: a qualitative study Risk Stratification of Sepsis, C. Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients Bronchoalveolar lavage during neutropenic episodes: diagnostic yield and cellular pattern Role of circulating lymphocytes in patients with sepsis Thrombocytopenia impairs host defense in gramnegative pneumonia-derived sepsis in mice Meta-analysis of randomized controlled trials of prophylactic granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor after autologous and allogeneic stem cell transplantation Blood platelets and sepsis pathophysiology: a new therapeutic prospect in critical ill patients? keywords: acute; antibiotic; failure; fever; infections; mortality; neutropenic; patients; risk; sepsis; therapy; use cache: cord-017420-tjwxec77.txt plain text: cord-017420-tjwxec77.txt item: #23 of 45 id: cord-017470-sjk7a34u author: Arlati, Sergio title: Pathophysiology of Acute Illness and Injury date: 2018-06-14 words: 16318 flesch: 30 summary: The endothelium is a key factor for production of remote organ damage as it exerts potent chemo-attracting effects on inflammatory cells, allows for leukocyte trafficking into tissues and organs, and promotes further inflammation by cytokines release. Induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55 Inflammatory cytokines and cell response in surgery Cox G IL6 is an anti-inflammatory cytokine required for controlling local or systemic acute inflammatory responses Procalcitonin as a diagnostic marker and IL-6 as a prognostic marker for sepsis Interleukin-6 levels act as a diagnostic marker for infection and a prognostic marker in patients with organ dysfunction in the intensive care unit Interleukin 6 is a useful marker for early prediction of the severity of acute pancreatitis Chemokine signaling in inflammation Complement activation in injured patients occurs immediately and is dependent on the severity of the trauma The role of the complement system in traumatic brain injury Femur fracture induces site-specific changes in T-cells immunity Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement Innate autoimmunity Natural antibodies, autoantibodies and complement activation in tissue injury Role of biological modifiers regulating the immune response after trauma The role of neuroinflammation in traumatic brain injury Evidence for a role of kallikrein-kinin system in patients with shock after blunt trauma Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases Platelets: bridging hemostasis, inflammation and immunity Coagulation abnormalities in acute lung injury and sepsis Priming for enhanced alveolar fibrin deposition after hemorrhagic shock: role for tumor necrosis factor New treatment strategies for disseminated intravascular coagulation based on current understanding of the pathophysiology Systemic inflammation and disseminated intravascular coagulation in early stage of ALI and ARDS: role of neutrophil and endothelial activation Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinases keywords: activation; acute; apoptosis; blood; cells; coagulation; cytokines; damage; dysfunction; endothelial; factor; immune; inflammation; inflammatory; injury; macrophages; monocytes; organ; patients; production; response; role; sepsis; shock; sirs; system; tissue; trauma; type cache: cord-017470-sjk7a34u.txt plain text: cord-017470-sjk7a34u.txt item: #24 of 45 id: cord-018284-grvj99eh author: Fresenius, Michael title: SIRS, Sepsis und Multiorganversagen date: 2014-10-04 words: 1026 flesch: 14 summary: Update A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-centre study Higher versus lower positive end-expiratory pressures in patients with acute respiratory distress syndrome Diagnostic approach to sepsis -state of the art Aktuelle Aspekte und Zukunft der Sepsisdiagnose Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis Diagnosis of sepsis: an evidence-based review Effects of drotrecogin alfa activated on microcirculation alterations in patients with severe sepsis Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock Cardiovascular management of septic shock Glucose Control in Critically Ill Patients Effects of high dosis of selenium, as sodium selenit, in septic shock: a placebo-controlled, randomized, double-blind, phase II study Aktivated protein C (Xigris) treatment in sepsis: d drug in trouble Sepsis: state of the art Crit Care 16 R94 und Annane Djilllali CRYSTMAS study adds to concerns about renal safety and increased mortality in sepsis patients Diagnostic value of procalcitonin, interleukin 6 and interleukin-8 in critically ill patients admitted with suspected sepsis The pathophysiology and treatment of sepsis Immunologic and hemodynamic effects of »low-dose« hydrocortisone in septic shock: a doubleblind, randomized, placebo-controlled, crossover study High dose vasopressin is not superior to norepinephrine in septic shock Immunmodulatory therapies in sepsis Early antimicrobial therapy in severe sepsis and septic shock SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference Multiple-center, randomized, placebocontrolled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock The Epidemiology of Sepsis in the United States from 1979 through 2000 Definition of sepsis Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care The Problems and Challenges of Immunotherapy in Sepsis Lactate in the critically ill patients: an outcome marker with the times Terlipressin for norepinephrin-resistant septic shock Beneficial effects of shortterm vasopressin infusion during severe septic shock Hydroxyethyl Starch 130/0.42 versus Ringer's Acetate in Severe Sepsis Hydroxyethylstarch and Ringer's lactate for fluid resuscitation in patients with severe sepsis -results from the VISEP-Study Diagnose und Therapie der Sepsis Therapie und Nachsorge der Sepsis (2010) Der Immunstatus kann anhand folgender Faktoren bestimmt werden: 4 Interleukin-6-Spiegel 4 Ausmaß der HLA-DR-Expression (Immunstimulation durch GM-CSF-Gabe zur Steigerung der Immunantwort oder Gabe von APC im Rahmen der Hyperfibrinolyse) 4 ex vivo TNF-Anstieg nach LPS-Gabe Verzicht auf intravenöse Selen-Gabe 2C Verzicht auf die Gabe von aktivierten Protein C (rhAPC) Drotrecogin alfa (activated) for adults with severe sepsis and low risk of death Empfehlungen zur Diagnostik und Therapie der Schockformen der IAG Schock der DIVI Critical illness Polyneuropathie und Criticall Illness Myopathy Epidemiology of sepsis and infection in ICU patients from international multicentre cohort study Intravenous immunoglobuline for treating sepsis and septic shock. keywords: der; einer; patients; sepsis; shock; study; und cache: cord-018284-grvj99eh.txt plain text: cord-018284-grvj99eh.txt item: #25 of 45 id: cord-018840-ts2g1ux7 author: Katragkou, Aspasia title: Role of Immunoglobulin Therapy to Prevent and Treat Infections date: 2018-06-19 words: 6706 flesch: 26 summary: Randomized trial in bone marrow transplant recipients Guidelines for the use of human immunoglobulin therapy in patients with primary immunodeficiencies in Latin America Some but not all benefits of intravenous immunoglobulin therapy after marrow transplantation appear to correlate with IgG trough levels A new paradigm for the treatment of sepsis: is it time to consider combination therapy? Primary immune deficiencies (PIDD) are one of the US Food and Drug Administration (FDA)approved indications for immunoglobulin therapy. keywords: antibody; clinical; diseases; igg; immune; immunoglobulin; infections; intravenous; ivig; patients; sepsis; therapy; treatment; use cache: cord-018840-ts2g1ux7.txt plain text: cord-018840-ts2g1ux7.txt item: #26 of 45 id: cord-020643-0yzkqykg author: Müller-Werdan, U. title: Schock date: 2006 words: 30700 flesch: 35 summary: 6.6.4 Traumatischer Schock -419 6.6.5 Anaphylaktischer Schock -419 Die Reduktion der effektiven Gewebeperfusion kann dabei hervorgerufen werden durch eine Abnahme der Herzleistung, durch Störungen der Makro-und Mikrozirkulation mit verminderter Perfusion, durch eine kritische Abnahme des Blutvolumens, eine Beeinträchtigung der O 2 -Aufnahme in der Lunge und der O 2 -Abgabe Noch ausstehend ist der Nachweis der klinischen Wirksamkeit einer Antioxidanzientherapie (Mullan u. McCloskey 2002) , der in zahlreichen Studien für folgende Substanzen nicht erbracht werden konnte: Superoxiddismutase, Katalase, Glutathionperoxidase, Ascorbinsäure, Glutathion, Harnsäure, α-Tocopherol, Karotinoide, der Xanthinoxidasehemmer Allopurinol, Lazaroide, Pyruvat (Fink 2003) , der Hemmung der Komplementaktivierung (Ciurana u. Hack 2002) , von PARP-Inhibitoren (Szabó u. Liaudet 2002; Liaudet et al. 2001 ) oder der Inhibition der MAP-Kinasen (Tulleken et al. 2001 ). keywords: abb; aber; abnahme; abschn; acute; adrenalin; aktivierung; akuten; allerdings; als; anaphylaxie; anstieg; apache; auch; auf; auf der; auf eine; aufgrund; auftreten; aus; bedeutung; behandlung; bei; bei der; bei einem; bei patienten; bei sepsis; beim; bereits; bis; bisher; blutdruck; blutung; bzw; cardiac; care; coronary; dabei; dafür; damit; dann; das; dass; defi; dem; der; des; die; diese; dobutamin; durch; durch die; durch eine; dysfunktion; eine; einsatz; einsatz von; endotoxin; erforderlich; erhöht; ersten; et al; etwa; failure; falle; führen; führt; für; für den; gabe; gabe von; haben; herz; herzindex; herzinfarkt; herzinsuffi; häufi; iabp; infarction; infl; infolge; innerhalb; inotrope; insbesondere; intensivpatienten; ist; ist bei; ist der; ist die; ist eine; jedoch; kann; kann die; kardiogenen; katecholamine; kgkg; klinische; kommen; kommt; konnte; kranken; kreislauf; kritisch; können; letalität; lässt; lösungen; mediatoren; medicine; mehr; min; mit; mit der; mit einer; mittels; mods; muss; myokarddepression; müller; nach; ndet; neben; nicht; noch; nur; oder; ohne; outcome; patienten; patienten mit; patients; pci; positiv; prognose; protein; reaktionen; reanimation; regel; registry; resuscitation; scheint; schock; schock ist; schockformen; schwerer; score; sehr; sein; selten; sepsis; sepsispatienten; septic; septischen; sich; sie; sind; sogar; sollte; sondern; sowie; sowohl; spezifi; stadium; stickoxid; studie; störungen; substanzen; systemischen; tabelle; tage; therapie; tnf; trauma; treatment; trial; trotz; und; und bei; und der; und eine; unter; ursache; vasopressin; ventricular; vergleich; volumensubstitution; von; von der; vor; weitere; weniger; werden; werden kann; wie; wird; wirkung; während; zienz; zu einer; zum; zur; zytokine; über cache: cord-020643-0yzkqykg.txt plain text: cord-020643-0yzkqykg.txt item: #27 of 45 id: cord-022592-g7rmzsv5 author: Wynn, James L. title: Pathophysiology of Neonatal Sepsis date: 2016-07-06 words: 22168 flesch: 30 summary: The expression of surface tissue factor apoprotein by blood monocytes in the course of infections in early infancy Complement and coagulation: strangers or partners in crime? Indications of coagulation and/ or fibrinolytic system activation in healthy and sick very-low-birth-weight neonates Coagulation, fibrinolytic and kallikrein systems in neonates with uncomplicated sepsis and septic shock Plasma antithrombin III and protein C levels in early recognition of late-onset sepsis in newborns Study of protein C, protein S, and antithrombin III in newborns with sepsis Low plasma protein C values predict mortality in low birth weight neonates with septicemia Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial The tissue factor and plasminogen activator inhibitor type-1 response in pediatric sepsis-induced multiple organ failure Evaluation and treatment of thrombocytopenia in the neonatal intensive care unit Low immature platelet fraction suggests decreased megakaryopoiesis in neonates with sepsis or necrotizing enterocolitis Whole blood platelet deposition on extracellular matrix under flow conditions in preterm neonatal sepsis The platelet hyporeactivity of extremely low birth weight neonates is age-dependent The Ashwell receptor mitigates the lethal coagulopathy of sepsis Platelet count and sepsis in very low birth weight neonates: is there an organism-specific response? Disseminated intravascular coagulation in the newborn Natural history of neonatal herpes simplex virus infections in the acyclovir era Protease-activated receptor-1: key player in the sepsis coagulation-inflammation crosstalk Increased numbers of macrophages in tracheal aspirates in premature infants with funisitis Neutrophil-derived microparticles induce myeloperoxidase-mediated damage of vascular endothelial cells Coagulation dysfunction in sepsis and multiple organ system failure Endothelial glucocorticoid receptor is required for protection against sepsis Admission angiopoietin levels in children with septic shock Group B streptococcal beta-hemolysin promotes injury of lung microvascular endothelial cells Pathophysiologic mechanisms of persistent pulmonary hypertension of the newborn Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice Correlation between susceptibility of infants to infections and interaction with neutrophils of Escherichia coli strains causing neonatal and infantile septicemia Innate cellular immune responses in newborns Impact of prematurity, stress and sepsis on the neutrophil respiratory burst activity of neonates Functional analysis of neutrophil granulocytes from healthy, infected, and stressed neonates Decreased bactericidal activity of leukocytes of stressed newborn infants Spontaneous and Fas-mediated apoptosis are diminished in umbilical cord blood neutrophils compared with adult neutrophils Mechanisms underlying reduced apoptosis in neonatal neutrophils Neonatal neutrophils with prolonged survival exhibit enhanced inflammatory and cytotoxic responsiveness Neutrophil extracellular traps kill bacteria Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus Neutrophil-derived circulating free DNA (cf-DNA/NETs): a potential prognostic marker for posttraumatic development of inflammatory second hit and sepsis Novel cell death program leads to neutrophil extracellular traps Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates Delayed but functional neutrophil extracellular trap formation in neonates Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens Outcomes following candiduria in extremely low birth weight infants Exhaustion of mature marrow neutrophils in neonates with sepsis Neutrophil storage pool depletion in neonates with sepsis and neutropenia Evaluation of risk factors for fatal neonatal sepsis Can neutrophil responses in very low birth weight infants predict the organisms responsible for late-onset bacterial or fungal sepsis? Neonatal sepsis has been inconsistently defined on the basis of a variety of clinical and laboratory criteria, which makes the study of this condition very difficult. keywords: activation; adults; bacterial; birth; blood; cells; children; development; expression; factor; failure; function; host; human; immune; immunity; infants; infection; inflammatory; levels; low; mortality; neonatal; neonates; newborn; onset sepsis; preterm; preterm infants; preterm neonates; production; protein; receptor; response; risk; role; sepsis; shock; weight cache: cord-022592-g7rmzsv5.txt plain text: cord-022592-g7rmzsv5.txt item: #28 of 45 id: cord-023935-o2ffxgnn author: Lorts, Angela title: Sepsis date: 2011-12-16 words: 11116 flesch: 34 summary: More recently, a polymorphism within the CD14 promoter gene (C to T transition at base pair -159) was identifi ed with a particular genotype over-represented among septic shock patients compared to healthy controls. It is believed that genetic differences among hosts are at least in part responsible for this variability in sepsis responses. keywords: ammatory; blood; children; il-1; infl; lps; mortality; oxygen; patients; pressure; protein; receptor; response; sepsis; shock; studies; tnf; uid; volume cache: cord-023935-o2ffxgnn.txt plain text: cord-023935-o2ffxgnn.txt item: #29 of 45 id: cord-028164-yn53209z author: Abe, Toshikazu title: Epidemiology of sepsis and septic shock in intensive care units between sepsis-2 and sepsis-3 populations: sepsis prognostication in intensive care unit and emergency room (SPICE-ICU) date: 2020-06-30 words: 3095 flesch: 50 summary: Table 1 shows characteristics of patients with infection in ICUs according to sepsis definitions. The trend in pathogens and antibiotics according to sepsis definitions was also nonspecific; however, blood culture positivity was lower if patients did not meet any definitions (sepsis-2 or sepsis-3), and carbapenem was more frequently used in patients who met any definitions (Table 2) . keywords: data; definitions; infection; mortality; patients; sepsis-3; study cache: cord-028164-yn53209z.txt plain text: cord-028164-yn53209z.txt item: #30 of 45 id: cord-030385-btf502ju author: Sun, Zhiheng title: 17β-Estradiol Promotes Trained Immunity in Females Against Sepsis via Regulating Nucleus Translocation of RelB date: 2020-07-22 words: 5878 flesch: 52 summary: Shock Effects of gender on the severity of sepsis Sexual dimorphism in bacterial infections Gender differences in trauma, shock and sepsis Sex and severe sepsis NFkappaB is a key player in the crosstalk between inflammation and cardiovascular diseases Mutations in the estrogen receptor alpha hormone binding domain promote stem cell phenotype through notch activation in breast cancer cell lines NFkappaB affects estrogen receptor expression and activity in breast cancer through multiple mechanisms An additive interaction between the NFkappaB and estrogen receptor signalling pathways in human endometrial epithelial cells Despite inhibition of nuclear localization of NF-kappa B p65, c-Rel, and RelB, 17-beta estradiol up-regulates NF-kappa B signaling in mouse splenocytes: the potential role of Bcl-3 BCG-induced trained immunity in NK cells: role for non-specific protection to infection Trained immunity: a new avenue for tuberculosis vaccine development Targeting SHIP-1 in myeloid cells enhances trained immunity and boosts response to infection The impact of sex hormones on BCG-induced trained immunity mTOR-and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity Increased acetylation of H3K14 in the genomic regions that encode trained immunity enzymes in lysophosphatidylcholine-activated human aortic endothelial cells-novel qualification markers for chronic disease risk factors and conditional DAMPs Severe sepsis and septic shock Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care Trained immunity: a smart way to enhance innate immune defence Differential involvement of RelB in morphine-induced modulation of chemotaxis, NO, and cytokine production in murine macrophages and lymphocytes RelB regulation of chemokine expression modulates local inflammation RelB cellular regulation and transcriptional activity are regulated by p100 Year in review in Intensive Care Medicine, 2008. In order to examine the effect of estradiol on trained immunity, we decided to pre-treat the macrophage cell lines with estradiol before trained immunity model. keywords: bmdms; cell; differences; estrogen; figure; immunity; lps; macrophage; male; mice; polarization; relb; sepsis cache: cord-030385-btf502ju.txt plain text: cord-030385-btf502ju.txt item: #31 of 45 id: cord-033064-3b4jv1zb author: Larsen, Reinhard title: Sepsis und septischer Schock date: 2016-06-14 words: 340 flesch: 50 summary: Schock, einer Unterform der Sepsis, muss die Herz-Kreislauf-Funktion mit kardiovaskulären Medikamenten und Volumenersatz gestützt werden. Trotz intensiver Bemühungen ist die Letalität der Sepsis unverändert hoch. keywords: der; die; sepsis; und cache: cord-033064-3b4jv1zb.txt plain text: cord-033064-3b4jv1zb.txt item: #32 of 45 id: cord-103081-k7ev5qkn author: Janosevic, Danielle title: The orchestrated cellular and molecular responses of the kidney to endotoxin define the sepsis timeline date: 2020-05-30 words: 4512 flesch: 49 summary: In fact, four hours after LPS administration, 155 cluster-specific GO terms were indistinguishable among the majority of cell types with 156 enrichment in terms related to defense, immune and bacterium responses (Fig. 5b) . Single cell RNA sequencing revealed the involvement of various cell populations in injury and repair to be temporally organized and highly orchestrated. keywords: cell; cluster; expression; fig; hours; kidney; rna; sepsis; supplementary; time; timeline cache: cord-103081-k7ev5qkn.txt plain text: cord-103081-k7ev5qkn.txt item: #33 of 45 id: cord-104180-f3hoz9bu author: Kirk-Bayley, Justin title: Recently published papers: inflammation, elucidation, manipulation? date: 2003-07-03 words: 1549 flesch: 37 summary: Glucocorticoid insufficiency in patients who present to the hospital with severe sepsis: a prospective clinical trial Adrenocortical hormones in survivors and nonsurvivors of severe sepsis: diverse time course of dehydroepiandrosterone, dehydroepiandrosterone-sulfate, and cortisol Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery Coagulation blockade prevents sepsis-induced respiratory and renal failure in baboons Blockade of tissue factor: treatment for organ injury in established sepsis Development of ionized hypomagnesemia is associated with higher mortality rates Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experi-Critical Care Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial Prevention of endotracheal suctioning-induced alveolar derecruitment in acute lung injury Dose-response characteristics during long-term inhalation of nitric oxide in patients with severe acute respiratory distress syndrome: a prospective, randomized, controlled study Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: Which is best? Bad medicine: low-dose dopamine in the ICU On the physiologic and clinical relevance of lung-borne cytokines during ventilator-induced lung injury Discrepancies between perceptions by physicians and nursing staff of intensive care unit end-of-life decisions A randomized trial of inhaled nitric oxide to prevent ischemia-reperfusion injury after lung transplantation Activated protein C inhibits the expression of platelet-derived growth factor in the lung Treatment of acute respiratory distress syndrome with recombinant surfactant protein C surfactant Impact of randomized trial results on acute lung injury ventilator therapy in teaching hospitals None declared. Looking at reduced endogenous steroid levels in sepsis, Marx and coworkers [2] focused on the androgens dehydroepiandrosterone (DHEA) and its sulphated precursor (DHEAS) and looked at disparity between survivors and nonsurvivors from severe sepsis. keywords: levels; lung; patients; sepsis cache: cord-104180-f3hoz9bu.txt plain text: cord-104180-f3hoz9bu.txt item: #34 of 45 id: cord-252859-zir02q69 author: Chung, T. Philip title: Molecular Diagnostics in Sepsis: From Bedside to Bench date: 2006-09-11 words: 5746 flesch: 41 summary: Using mouse spleen samples for gene expression analysis, we were able to classify the samples as CLP or Sham with 96.0% accuracy, estimated using cross-validation. Because the clinical use of gene expression analysis using splenic tissue is severely limited, we explored next the use of circulating blood for class prediction in our mouse models. keywords: analysis; blood; clp; data; expression; gene; human; inflammation; mouse; patients; samples; sepsis; spleen cache: cord-252859-zir02q69.txt plain text: cord-252859-zir02q69.txt item: #35 of 45 id: cord-261633-r4qlbnc5 author: Xie, Guo-Hao title: Defensins and Sepsis date: 2014-08-19 words: 2928 flesch: 35 summary: Sepsis, severe sepsis, and septic shock represent a continuum of clinical syndromes which are common complications observed in patients with infection, trauma, and major surgeries [1] [2] [3] . Epidemiology studies demonstrated that severe sepsis has a population prevalence of 300/100 000 in the United States and counts for 10-30% of the intensive care unit (ICU) patients [4] [5] [6] . keywords: defensins; expression; gene; human; lung; number; patients; sepsis; studies cache: cord-261633-r4qlbnc5.txt plain text: cord-261633-r4qlbnc5.txt item: #36 of 45 id: cord-270213-ygb64yxc author: Williams, Alexander T. title: Control of systemic inflammation throughearly nitric oxide supplementation with nitric oxide releasing nanoparticles date: 2020-10-02 words: 2309 flesch: 23 summary: 477 478 Conclusion 479 Pathogenetic Mechanisms of Septic Shock 506 Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and 507 associated costs of care Epidemiology of severe sepsis Severe Sepsis and Septic Shock Sepsis and endothelial permeability Novel therapies for microvascular permeability in 515 sepsis The microcirculation is the motor of sepsis Severe abnormalities in microvascular perfused vessel density are associated 520 to organ dysfunctions and mortality and can be predicted by hyperlactatemia and 521 norepinephrine requirements in septic shock patients Microvascular resuscitation as a therapeutic goal in 523 severe sepsis 525 Early difference in tissue pH and microvascular hemodynamics in hemorrhagic shock 526 resuscitation using polyethylene glycol-albumin-and hydroxyethyl starch-based plasma 527 expanders B. & Intaglietta, M. Microcirculation: Its Significance in Clinical and Molecular Microcirculation: Physiology, Pathophysiology, and 532 Clinical Application Clinical review: Clinical imaging of the 534 sublingual microcirculation in the critically ill -where do we stand? LPS/TLR4 signal transduction pathway Animal Models of sepsis: setting the stage Sustained release nitric oxide releasing nanoparticles: characterization of a novel 542 delivery platform based on nitrite containing hydrogel/glass composites A nanoparticle delivery vehicle for S-nitroso-N-acetyl cysteine: 546 Sustained vascular response 548 Sustained release nitric oxide from long-lived circulating nanoparticles. Medical care costs related to sepsis treatment add up to 68 approximately $20 billion in the United States. keywords: endothelial; glycocalyx; microvascular; nitric; oxide; sepsis cache: cord-270213-ygb64yxc.txt plain text: cord-270213-ygb64yxc.txt item: #37 of 45 id: cord-297039-vfuem6bk author: Beltrán-García, Jesús title: Circular RNAs in Sepsis: Biogenesis, Function, and Clinical Significance date: 2020-06-25 words: 7510 flesch: 35 summary: The novel roles of circular RNAs in metabolic organs Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection Cytokine storm and sepsis disease pathogenesis Another Road to Sepsis and Its Therapeutic Targeting Modulation of TNF-α mRNA stability by human antigen R and miR181s in sepsis-induced immunoparalysis miRNA-125b regulates TNF-α production in CD14+ neonatal monocytes via post-transcriptional regulation Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1 Multiplex cytokine profiling in patients with sepsis Dysregulation in microRNA expression in peripheral blood mononuclear cells of sepsis patients is associated with immunopathology Attenuation of Cardiac Dysfunction in Polymicrobial Sepsis by MicroRNA-146a Is Mediated via Targeting of IRAK1 and TRAF6 Expression Toll-like receptor-mediated NF-kappaB activation: A phylogenetically conserved paradigm in innate immunity A human homologue of the Drosophila Toll protein signals activation of adaptive immunity Elevation of IL-18 in human sepsis IL-18) levels in patients with sepsis IL-27 Enhances LPS-Induced Proinflammatory Cytokine Production via Upregulation of TLR4 Expression and Signaling in Human Monocytes IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells Circular RNA circ-4099 is induced by TNF-α and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration Follow-up study identifies two novel susceptibility loci PRKCB and 8p11.21 for systemic lupus erythematosus Calcitonin gene-related peptide induces IL-6 expression in RAW264.7 macrophages mediated by mmu_circRNA_007893 CircRNA hsa_circ_0005105 upregulates NAMPT expression and promotes chondrocyte extracellular matrix degradation by sponging miR-26a The down-regulation of hsa_circ_0012919, the sponge for miR-125a-3p, contributes to DNA methylation of CD11a and CD70 in CD4+ T cells of systemic lupus erythematous Persistent inflammation and immunosuppression: A common syndrome and new horizon for surgical intensive care MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development MicroRNA control in the immune system: BBasic principles MicroRNA miR-223 as regulator of innate immunity Impact of miR-223-3p and miR-2909 on inflammatory factors IL-6, IL-1ß, and TNF-α, and the TLR4/TLR2/NF-κB/STAT3 signaling pathway induced by lipopolysaccharide in human adipose stem cells Hsa_circ_0003159 inhibits gastric cancer progression by regulating miR-223-3p/NDRG1 axis Serum miR-146a and miR-223 as potential new biomarkers for sepsis NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses The prognostic value of plasma microRNA-155 and microRNA-146a level in severe sepsis and sepsis-induced acute lung injury patients Circular RNA RSF1 promotes inflammatory and fibrotic phenotypes of irradiated hepatic stellate cell by modulating miR-146a-5p Circular RNA expression alterations in colon tissues of Crohn's disease patients Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer MiR-125b but not miR-125a is upregulated and exhibits a trend to correlate with enhanced disease severity, inflammation, and increased mortality in sepsis patients Circular RNA GLI2 promotes osteosarcoma cell proliferation, migration, and invasion by targeting miR-125b-5p Circulating plasma microRNAs can differentiate human sepsis and Systemic Inflammatory Response Syndrome (SIRS) NSD2 circular RNA promotes metastasis of colorectal cancer by targeting miR-199b-5p-mediated DDR1 and JAG1 signalling Circular RNA 0000096 affects cell growth and migration in gastric cancer Circular RNA circHIPK3 Promotes the Proliferation and Differentiation of Chicken Myoblast Cells by Sponging miR-30a-3p Circular RNA Signature in Hepatocellular Carcinoma CircRNA-9119 regulates the expression of prostaglandin-endoperoxide synthase 2 (PTGS2) by sponging miR-26a in the endometrial epithelial cells of dairy goat Circular RNA circTRIM33-12 acts as the sponge of MicroRNA-191 to suppress hepatocellular carcinoma progression Sepsis: Older and newer concepts Circular RNA circ-Foxo3 induced cell apoptosis in urothelial carcinoma via interaction with miR-191-5p Basophil Recruitment to Skin Lesions of Patients with Systemic Lupus Erythematosus Mediated by CCR1 and CCR2 Sepsis definitions: Time for change The Clinical Challenge of Sepsis Identification and Monitoring Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock Early versus delayed administration of norepinephrine in patients with septic shock Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: Results from a guideline-based performance improvement program Diagnostic and prognostic markers in sepsis New approaches to sepsis: Molecular diagnostics and biomarkers MiR-145 negatively regulates TGFBR2 signaling responsible for sepsis-induced acute lung injury Function and clinical significance of circRNAs in solid tumors Matrix-metalloproteinases and their inhibitors are elevated in severe sepsis: Prognostic value of TIMP-1 in severe sepsis Matrix metalloproteinase-14 triggers an anti-inflammatory proteolytic cascade in endotoxemia Predictive value of miRNA-29a and miRNA-10a-5p for 28-day mortality in patients with sepsis-induced acute kidney injury. keywords: biogenesis; biomarkers; cells; circrnas; circular; expression; function; human; linear; patients; process; response; role; sepsis; septic; splicing cache: cord-297039-vfuem6bk.txt plain text: cord-297039-vfuem6bk.txt item: #38 of 45 id: cord-298505-r7ihqb96 author: Górski, Andrzej title: Sepsis, Phages, and COVID-19 date: 2020-10-15 words: 3741 flesch: 41 summary: Thus, clinical trials assessing the value of phage therapy in sepsis, including viral sepsis, are urgently needed. In this review, we summarize the progress in treating sepsis with phage therapy over the last three years. keywords: blood; cells; covid-19; human; patients; phage; sepsis; therapy; treatment cache: cord-298505-r7ihqb96.txt plain text: cord-298505-r7ihqb96.txt item: #39 of 45 id: cord-302295-nblmshni author: Savva, Athina title: Targeting Toll-Like Receptors: Promising Therapeutic Strategies for the Management of Sepsis-Associated Pathology and Infectious Diseases date: 2013-11-18 words: 10341 flesch: 30 summary: Prophylactic administration of anti-TLR4 antibodies blunted TNF production and strikingly increased survival in E. coli sepsis, from 0% in the control antibody group to 80% in the anti-TLR4 group. Our studies demonstrate that anti-TLR4 antibodies are efficient as adjunctive therapy for E. coli sepsis, with a window of clinical application comprising prophylactic and therapeutic intervention opportunities. keywords: activation; anti; cells; human; infection; lps; mice; patients; phase; production; receptor; results; sepsis; studies; study; tlr2; tlr3; tlr4; toll; treatment; trial; virus cache: cord-302295-nblmshni.txt plain text: cord-302295-nblmshni.txt item: #40 of 45 id: cord-302379-jh6jxwyn author: Jevon, Phil title: Management of odontogenic infections and sepsis: an update date: 2020-09-25 words: 3426 flesch: 45 summary: A retrospective study of 110 patients Deep neck abscesseschanging trends Life-threatening oro-facial infections Peterson's principles of oral and maxillofacial surgery Deep space neck infection: principles of surgical management Prescribing in Dental Practice Increasing frequency and severity of odontogenic infection requiring hospital admission and surgical management Ludwig's angina Ludwig's angina Management of head and neck infections in the immunocompromised patient Organ reserve, excess metabolic capacity, and aging Influence of Aging and Environment on Presentation of Infection in Older Adults Criteria for admission of odontogenic infections at high risk of deep neck space infection Irrigating drains for severe odontogenic infections do not improve outcome Antibiotic selection in head and neck infections Pharmacology of Local Anaesthetics Used in Oral Surgery Is conservative treatment of deep neck space infections appropriate? Evaluation of bacterial spectrum of orofacial infections and their antibiotic susceptibility Severe odontogenic infections. 14 Relying on antibiotics only in relieving dental infection is likely to be less effective and can cause antimicrobial resistance. keywords: care; infection; management; patients; practice; sepsis; treatment cache: cord-302379-jh6jxwyn.txt plain text: cord-302379-jh6jxwyn.txt item: #41 of 45 id: cord-312197-d5d8amk7 author: Edmond, Karen title: New Approaches to Preventing, Diagnosing, and Treating Neonatal Sepsis date: 2010-03-09 words: 5228 flesch: 35 summary: key: cord-312197-d5d8amk7 authors: Edmond, Karen; Zaidi, Anita title: New Approaches to Preventing, Diagnosing, and Treating Neonatal Sepsis date: 2010-03-09 journal: PLoS Med DOI: 10.1371/journal.pmed.1000213 sha: doc_id: 312197 cord_uid: d5d8amk7 Karen Edmond and Anita Zaidi highlight new approaches that could reduce the burden of neonatal sepsis worldwide. Neonatal sepsis or septicaemia is a clinical syndrome characterized by systemic signs of circulatory compromise (e.g., poor peripheral perfusion, pallor, hypotonia, poor responsiveness) caused by invasion of the bloodstream by bacteria in the first month of life. keywords: blood; care; countries; health; income; infants; infections; mortality; neonatal; neonates; rates; sepsis; studies cache: cord-312197-d5d8amk7.txt plain text: cord-312197-d5d8amk7.txt item: #42 of 45 id: cord-347833-b3yrxkt0 author: Ahlström, Björn title: A nationwide study of the long-term prevalence of dementia and its risk factors in the Swedish intensive care cohort date: 2020-09-04 words: 4346 flesch: 50 summary: Such an approach allows for an accurate assessment of comorbidities in general and pre ICU dementia in particular. The date of dementia diagnosis was the first occurrence of the condition in the NPR or the SveDem. keywords: care; cohort; dementia; diagnosis; icu; patients; risk; sepsis cache: cord-347833-b3yrxkt0.txt plain text: cord-347833-b3yrxkt0.txt item: #43 of 45 id: cord-348785-f67amppy author: Kapicibaşi, Hasan Oğuz title: Pulmonary effects of ozone therapy at different doses combined with antibioticotherapy in experimental sepsis model date: 2020-07-13 words: 2697 flesch: 41 summary: Pharmacology and toxicology of ozonetherapy today Oxygen-ozone immunoceutical therapy in COVID-19 outbreak: facts and figures Toxicity and biochemical mechanisms of ozone Gaseous ozone treatment inactivates Listeria innocua in vitro Efficacy of hyperbaric oxygen therapy and medical ozone therapy in experimental acute necrotizing pancreatitis Repetitive pneumoperitoneum with ozonized oxygen as a preventive in lethal polymicrobial sepsis in rats Pulmonary effects of ozone therapy at different doses combined with antibioticotherapy in experimental sepsis model IL-33 drives augmented responses to ozone in obese mice γδ T cells are required for M2 macrophage polarization and resolution of ozone-induced pulmonary inflammation in mice Role of neutralizing anti-murine interleukin-17A monoclonal antibody on chronic ozone-induced airway inflammation in mice Çakır et al. 32 reported the systemic inflammatory response markers of TNF-alpha and IL-1B levels reduced after ozone treatment. keywords: effects; group; inflammation; injury; ozone; rats; sepsis; therapy cache: cord-348785-f67amppy.txt plain text: cord-348785-f67amppy.txt item: #44 of 45 id: cord-349076-x3rjasg0 author: Jarczak, Dominik title: Use of Intravenous Immunoglobulins in Sepsis Therapy—A Clinical View date: 2020-08-03 words: 7030 flesch: 30 summary: Impact of neutrophil and organism age on neutrophil extracellular trap formation Neutrophil extracellular traps in sepsis A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma Myeloid-derived suppressor cells coming of age Intravenous immunoglobulins-understanding properties and mechanisms Innate response activator B cells: Origins and functions Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis An extended leukocyte differential count (16 types of circulating leukocytes) using the cytodiff flow cytometric system can provide informations for the discrimination of sepsis severity and prediction of outcome in sepsis patients Early alterations of B cells in patients with septic shock Alterations of B Cells in Immunosuppressive Phase of Septic Shock Patients Reduced circulating B cells and plasma IgM levels are associated with decreased survival in sepsis-A meta-analysis Early levels in blood of immunoglobulin M and natural killer cells predict outcome in nonseptic critically ill patients Bench-to-bedside review: Immunoglobulin therapy for sepsis-biological plausibility from a critical care perspective Can Concurrent Abnormalities in Free Light Chains and Immunoglobulin Concentrations Identify a Target Population for Immunoglobulin Trials in Sepsis? Nevertheless, the Surviving Sepsis Campaign (SSC) guidelines suggested against IVIg use in sepsis therapy 2016 due to lack of sufficient evidence of efficacy for preparations containing only IgG keywords: activation; anti; cells; igg; igm; immunoglobulins; intravenous; ivig; patients; response; sepsis; shock; therapy; use cache: cord-349076-x3rjasg0.txt plain text: cord-349076-x3rjasg0.txt item: #45 of 45 id: cord-354384-bshj0w3o author: Tanak, Ambalika S. title: Multiplexed cytokine detection using electrochemical point-of-care sensing device towards rapid sepsis endotyping date: 2020-10-19 words: 6723 flesch: 38 summary: DETecT Sepsis sensor provides a descriptive understanding of the host immune response with the pentaplex biomarker strategy enabling patient stratification to predict timely evidence on the arc of sepsis. DETecT Sepsis sensor can be used effectively in the emergency department for early sepsis screening, or it can be used to monitor sepsis prognosis for patients as a bedside monitoring device. keywords: biomarkers; detect; detection; il-10; il-8; immune; patient; plasma; response; sensor; sepsis; trail cache: cord-354384-bshj0w3o.txt plain text: cord-354384-bshj0w3o.txt