id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
cord-342047-pm3i54mb	Du Preez, Andrea	The type of stress matters: repeated injection and permanent social isolation stress in male mice have a differential effect on anxiety- and depressive-like behaviours, and associated biological alterations	2020-09-21		.txt	text/plain	8842	279	27	Mice were exposed to one of four experimental conditions after an initial 1week habituation period: (i) stress-free control group (socially-housed in pairs and injection naive-Group 1); (ii) repeated injection stress (sociallyhoused in pairs and repeatedly injected-Group 2); (iii) social isolation stress (permanent social isolation and injection naive-Group 3); and (iv) combined stress (permanent isolation and repeatedly injected-Group 4). We first assessed the behavioural effects associated with chronic stress exposure and found that all stress-exposed mice, irrespective of the type of stress, exhibited significantly increased anxiety-like behaviour in the OFT (Fig. 2a) relative to control animals, as shown by significantly less time in the centre of the OFT arena (−59% in repeatedly injected animals, −92% in the socially isolated mice and −74% in animals exposed to combined stress spent (Fig. 2a) ).	cache/cord-342047-pm3i54mb.txt	txt/cord-342047-pm3i54mb.txt
