item: #1 of 156
          id: cord-000082-jy7j8sh0
      author: Huang, Ting
       title: Evidence of Recombination and Genetic Diversity in Human Rhinoviruses in Children with Acute Respiratory Infection
        date: 2009-07-27
       words: 6209
      flesch: 50
     summary: However, discrepancies have appeared in the classification of some of the new HRV-A or HRV-C strains, depending on the size and location of the nucleotide sequence in the viral genome and on the phylogenetic methods used for direct analysis of HRV sequences Prior evidence of putative novel rhinovirus species 59 noncoding region alone does not unequivocally determine genetic type of human rhinovirus strains Distinguishing molecular features and clinical characteristics of a putative new rhinovirus species, human rhinovirus C (HRV C) Genome-wide diversity and selective pressure in the human rhinovirus Frequent detection of human rhinoviruses, paramyxoviruses, coronaviruses, and bocavirus during acute respiratory tract infections Novel species of human rhinoviruses in acute otitis media Human rhinovirus group C infection in children with lower respiratory tract infection Novel human rhinoviruses and exacerbation of asthma in children Genomic features of intertypic recombinant sabin poliovirus strains excreted by primary vaccinees Recombination in circulating enteroviruses Improved molecular identification of enteroviruses by RT-PCR and amplicon sequencing Co-circulation and evolution of polioviruses and species C enteroviruses in a district of Madagascar Evidence of recombination among enteroviruses Frequency and dynamics of recombination within different species of human enteroviruses Genome analysis of circulating picornavirus reveals rhinovirus recombination and a new enterovirus serotype.
    keywords: 59utr; hrv; recombination; sequences; species; strains; table; vp2
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        item: #2 of 156
          id: cord-001116-2yvyiiuy
      author: Nikas, Jason B.
       title: Inflammation and Immune System Activation in Aging: A Mathematical Approach
        date: 2013-11-19
       words: 4536
      flesch: 39
     summary: I used the independent t-Test for parametric gene variables (both normality and homogeneity of variance conditions were met); the Aspin-Welch unequal-variance test (AW) for gene variables that met the normality condition but not the homogeneity of variance condition; and the Mann-Whitney U test (MW) for the non-parametric gene variables, i.e., for those variables that i) the normality condition was not met or ii) the normality and the homogeneity of variance conditions were not met. Such a model would be valuable in future studies of global gene expression analysis of post-mortem hippocampal tissue investigating biological and chronological aging.
    keywords: aging; expression; genes; process; subjects; table
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        item: #3 of 156
          id: cord-001186-jkg7qkj6
      author: Skowronski, Danuta M.
       title: Randomized Controlled Ferret Study to Assess the Direct Impact of 2008–09 Trivalent Inactivated Influenza Vaccine on A(H1N1)pdm09 Disease Risk
        date: 2014-01-27
       words: 8888
      flesch: 34
     summary: Four observational studies from Canada Seasonal influenza vaccine and increased risk of pandemic A/H1N1-related illness: first detection of the association in British Columbia Clinical and epidemiologic characteristics of an outbreak of novel H1N1 (swine origin) influenza A virus among United States military beneficiaries Association between seasonal influenza vaccination in 2008-2009 and pandemic influenza A (H1N1) 2009 infection among school students from Kobe Effectiveness of pandemic H1N1 vaccine against influenza-related hospitalization in children Effectiveness of 2008-09 trivalent influenza vaccine against 2009 pandemic influenza A (H1N1) -United States Notes from the field: outbreak of 2009 pandemic influenza A (H1N1) virus at a large public university in Delaware Pandemic influenza H1N1 2009 infection in Victoria, Australia: no evidence for harm or benefit following receipt of seasonal influenza vaccine in 2009 No association between 2008-09 influenza vaccine and influenza A(H1N1)pdm09 virus infection Partial protection of seasonal trivalent inactivated vaccine against novel pandemic influenza A/H1N1 2009: case control study in Mexico City Infection and deaths from influenza A H1N1 virus in Mexico: a retrospective analysis Protective efficacy of seasonal influenza vaccination against seasonal and pandemic influenza virus infection during 2009 in Hong Kong Mechanism for seasonal vaccine effect on pandemic H1N1 risk remains uncertain Comparison of a live attenuated 2009 H1N1 vaccine with seasonal influenza vaccines against 2009 pandemic H1N1 virus infection in mice and ferrets Seasonal influenza vaccine provides priming for A/H1N1 immunization Assessment of the efficacy of commercially available and candidate vaccines against a pandemic H1N1 2009 virus Impact of prior seasonal influenza vaccination and infection on pandemic A(H1N1) influenza virus replication in ferrets Efficacy of vaccination with different combinations of MF59-adjuvanted and non-adjuvanted seasonal and pandemic influenza vaccines against pandemic H1N1 (2009) influenza virus infection in ferrets Efficacy of seasonal live attenuated influenza vaccine against virus replication and transmission of a pandemic 2009 H1N1 virus in ferrets World Health Organization. WHO recommendations on the composition of influenza virus vaccines Cross-lineage influenza B and heterologous influenza A antibody responses in vaccinated mice: immunologic interactions and B/Yamagata dominance Oseltamivirresistant pandemic A/H1N1 virus is as virulent as its wild-type counterpart in mice and ferrets The 2009 pandemic H1N1 D222G hemagglutinin mutation alters receptor specificity and increases virulence in mice but not in ferrets Global Influenza Surveillance Network Manual for the laboratory diagnosis and virological surveillance of influenza IDEXX product brochure Profiling of humoral immune responses to influenza viruses by using protein microarray Enhanced expression of an alpha2,6-linked sialic acid on MDCK cells improves isolation of human influenza viruses and evaluation of their sensitivity to a neuraminidase inhibitor Enhanced lung disease and Th2 response following human metapneumovirus infection in mice immunized with the inactivated virus Early cytokine mRNA expression profiles predict Morbillivirus disease outcome in ferrets Molecular cloning and phylogenetic analysis of inflammatory cytokines of the ferret (Mustela putorius furo) Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation A new mathematical model for relative quantification in realtime RT-PCR Protective efficacy against pandemic influenza of seasonal influenza vaccination in children in Hong Kong: a randomized controlled trial The ferret as a model organism to study influenza A virus infection Vaccination against human influenza A/H3N2 virus prevents the induction of heterosubtypic immunity against lethal infection with avian influenza A/H5N1 virus Yearly influenza vaccinations: a double-edged sword? Seasonal influenza vaccination and the risk of infection with pandemic influenza: a possible illustration of nonspecific temporary immunity following infection Understanding dengue pathogenesis: implications for vaccine design An in-depth analysis of original antigenic sin in dengue virus infection Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes High titer and avidity of nonneutralizing antibodies against influenza vaccine antigen are associated with severe influenza Failure of protection and enhanced pneumonia with a US H1N2 swine influenza virus in pigs vaccinated with an inactivated classical swine H1N1 vaccine Enhanced pneumonia and disease in pigs vaccinated with an inactivated humanlike (d-cluster) H1N2 vaccine and challenged with pandemic 2009 H1N1 influenza virus Kinetics of lung lesion development and pro-inflammatory cytokine response in pigs with vaccine-associated enhanced respiratory disease induced by challenge with pandemic (2009)
    keywords: a(h1n1)pdm09; animals; antibody; ch+5; day; ferrets; group; infection; influenza; lung; pandemic; placebo; seasonal; table; tiv; vaccinated; vaccine; virus
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        item: #4 of 156
          id: cord-001521-l36f1gp7
      author: None
       title: Oral and Poster Manuscripts
        date: 2011-04-08
       words: 183853
      flesch: 46
     summary: The concept that swine are a mixing-vessel for the reassortment of influenza viruses and for the emergence of pandemic influenza viruses has been re-enforced by the emergence of the recent pandemic. This study was supported by Contract HHSN266200700005C from the National Institute of Allergy and Infectious Diseases, National Institutes of Pigs have been considered as hypothetical 'mixing vessels' facilitating the genesis of pandemic influenza viruses.
    keywords: age; analysis; animals; antibodies; antibody; antiviral; assay; associated; avian; b viruses; b ⁄; balb ⁄; binding; c virus; c ⁄; cases; cells; challenge; children; control; cross; culture; data; days; detection; disease; dk ⁄; dose; effect; ferrets; figure; following; gene; group; h1n1 influenza; h1n1 pandemic; h1n1 virus; h5n1 infection; h5n1 viruses; h9n2; health; high; hong; hours; human h1n1; human influenza; humans; immunity; infected; infections; influenza antigenic; influenza c; influenza epidemic; influenza infection; influenza influenza; influenza neuraminidase; influenza outbreaks; influenza pandemic; influenza patients; influenza research; influenza samples; influenza season; influenza strains; influenza surveillance; influenza transmission; influenza vaccination; influenza vaccine; influenza virus; isolates; kong ⁄; laboratory; laiv; lg ⁄; like; low; lung; mallard ⁄; mdck; method; mg ⁄; mice; model; mutation; nasal; new; non; novel; number; observed; origin influenza; oseltamivir; patients; pcr; period; pigs; population; positive; post; potential; potsdam ⁄; protection; protein; public; rate; research; resistance; respiratory; response; results; risk; rna; samples; school; seasonal; sensitivity; sequence; serum; severe; specific; specimens; studies; study; subjects; subtype influenza; sw ⁄; swine influenza; swine viruses; system; t ⁄; table; test; time; treatment; type virus; vaccines; values; virus gene; virus infection; virus isolation; virus ns1; virus replication; virus strains; virus titers; virus transmission; virus vaccine; virus ⁄; viruses; wave; years; ⁄ brisbane; ⁄ california; ⁄ genoa; ⁄ h1n1; ⁄ h3n2; ⁄ h5n1; ⁄ hk; ⁄ hok; ⁄ lee; ⁄ leningrad; ⁄ ml; ⁄ netherlands; ⁄ ns1; ⁄ panama; ⁄ pr8; ⁄ vietnam
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        item: #5 of 156
          id: cord-001567-3bw7jbzq
      author: Borlak, Jürgen
       title: Proteome mapping of epidermal growth factor induced hepatocellular carcinomas identifies novel cell metabolism targets and mitogen activated protein kinase signalling events
        date: 2015-02-25
       words: 14018
      flesch: 33
     summary: Categorization of tumour regulated proteins based on ontology terms 82 non-redundant tumour proteins covering To, UR and DR categories were considered and analysed for Ontologies using the GeneXplain software (v.2.4.1), the biological pathways tools Reactome (http://www.REACTOME.org) and KEGG (http://www.genome.jp/kegg) and WikiPathways (http://wikipathways.org). It is designed to find master regulatory molecules upstream of an input list of regulated tumour proteins.
    keywords: acid; cancer; carcinoma; cell; disease; egf; egfr; expression; figure; file; gene; growth; hcc; human; liver; master; metabolism; mice; min; network; pathway; proteins; receptor; regulation; serum; signalling; specific; study; table; transgenic; tumour
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        item: #6 of 156
          id: cord-001890-kbiwze0z
      author: Zhang, Huimin
       title: Two novel regulators of N‐acetyl‐galactosamine utilization pathway and distinct roles in bacterial infections
        date: 2015-11-05
       words: 9627
      flesch: 43
     summary: Consequently, the N-terminal hexahistidine tagged S. suis AgaR2 protein was purified to homogeneity and gave a single-protein band of appropriate molecular mass (~31 kDa for monomer) (Fig. 4A) . Additionally, we also used S. suis AgaR2 protein to evaluate the function of the two AgaR-binding sites in front of the EF1809 locus of E. faecalis V583, a close relative of S. suis.
    keywords: agar2; binding; catabolism; et al; expression; feng; fig; galnac; genes; genomes; pathway; probe; protein; regulator; sites; streptococcus; suis; table; utilization
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        item: #7 of 156
          id: cord-001933-rnjnxymc
      author: Kariithi, Henry M.
       title: Comparative Analysis of Salivary Gland Proteomes of Two Glossina Species that Exhibit Differential Hytrosavirus Pathologies
        date: 2016-02-09
       words: 9478
      flesch: 38
     summary: Such antiviral approaches are applicable in the control of virus infections in mass production of other insects. Notably, our annotation of the nine proteins revealed that these proteins may be involved in pathways related to the host's antiviral responses to virus infection (See Table 2 and the references therein).
    keywords: alla; et al; expression; figure; flies; g. m.; g. pallidipes; glossina; gpsghv; host; infected; infection; morsitans; proteins; replication; salivary; symptoms; table; tsetse; virus; viruses
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        item: #8 of 156
          id: cord-001974-wjf3c7a7
      author: Friis-Nielsen, Jens
       title: Identification of Known and Novel Recurrent Viral Sequences in Data from Multiple Patients and Multiple Cancers
        date: 2016-02-19
       words: 5776
      flesch: 43
     summary: Sequence clusters that have been described in detail throughout the manuscript have been included as supplementary files. A grouping based on taxonomy, or a more data-driven approach that cluster sequence groups based on the associated datasets as seen in Figure 2 , could be included as another iteration to properly strengthen the statistical associations.
    keywords: associations; cancer; clustering; clusters; contigs; data; features; human; parameters; samples; sequences; sequencing; species; table; virus
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        item: #9 of 156
          id: cord-002139-zlqh436d
      author: Chasman, Deborah
       title: Integrating Transcriptomic and Proteomic Data Using Predictive Regulatory Network Models of Host Response to Pathogens
        date: 2016-07-12
       words: 14809
      flesch: 38
     summary: We (1) infer a regulatory module network based on changes in mRNA abundance under viral infection and (2) predict protein regulators whose abundances are predictive of gene expression in the modules. For human, the H1N1 NL time course and a short replicate time course of H1N1 CA04 were missing (see gray boxes in protein regulator heatmap at the bottom of Figs 8, 9, S7A and S8A); for mouse, the missing samples spanned H5N1 HAavir and two of four dosages of H1N1 CA04.
    keywords: data; edges; expression; fig; gene; host; human; influenza; lasso; merlin; module; mouse; mrna; mtg; network; pathogenicity; protein; regulators; replication; response; signaling; time; virus; viruses
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        item: #10 of 156
          id: cord-002846-la9svzml
      author: Strohl, William R.
       title: Current progress in innovative engineered antibodies
        date: 2017-08-18
       words: 13143
      flesch: 25
     summary: Moreover, the potency of T cell redirected bispecific antibodies depends on the affinity of the arms for each antigen. Even with the absence of Fc activity, many treatments with T cell redirecting bispecific antibodies are accompanied by cytokine storms that need to be addressed as part of the therapeutic paradigm .
    keywords: activity; adcs; antibodies; antibody; antigen; binding; bispecific; cancer; car; cell; delivery; drug; et al; fusion; human; igg; immune; molecules; phase; proteins; receptor; stage; t cell; table; targeting; targets; treatment; trials; tumor
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        item: #11 of 156
          id: cord-003318-abs9rvjk
      author: Liu, Ming
       title: The enzymatic biosynthesis of acylated steroidal glycosides and their cytotoxic activity
        date: 2018-05-01
       words: 7893
      flesch: 46
     summary: Likewise, E-17β-G (9a) was acetylated by EcSGA1 to form monoacetylated products 9b-9e in a ratio of 80:10:6:4. shown in Supplementary Information Fig. 1B and Supplementary Information Fig. S4 ) was first assessed as sugar Table S3 ).
    keywords: asgs; cell; ecsga1; fig; figs; glycosides; hydroxyl; information; information fig; laca; ossgt1; protein; steroidal; table; testosterone; udp
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        item: #12 of 156
          id: cord-003532-lcgeingz
      author: None
       title: 39th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, 19-22 March 2019
        date: 2019-03-19
       words: 80115
      flesch: 48
     summary: Blood cultures were sent as per clinical & laboratory diagnosis of sepsis in ICU patients. Conclusions: HR, lactate levels and age before AVP initiation can predict the response to AVP in ICU patients with NE-resistant hypotension.
    keywords: acute; admission; age; aim; aki; analysis; arrest; arterial; assessment; baseline; blood; cardiac; care; care unit; cases; clinical; complications; conclusions; correlation; critical; data; days; diagnosis; difference; discharge; ecmo; effect; emergency; factors; failure; fig; figure; fluid; group; high; hospital; hospital mortality; hours; icu; icu admission; icu patients; ill; incidence; increase; injury; intensive; intervention; introduction; lactate; length; levels; low; lung; management; map; mean; median; medical; methods; months; mortality; non; organ; outcome; patients; patients introduction; period; post; pressure; rate; ratio; response; results; resuscitation; risk; score; sepsis; sepsis patients; septic; serum; severity; shock patients; sofa; stay; studies; study; surgery; survival; system; table; test; therapy; time; total; trauma; treatment; ultrasound; unit; use; ventilation; years
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        item: #13 of 156
          id: cord-003707-fbe47bgi
      author: Russo, Alice G
       title: Novel insights into endogenous RNA viral elements in Ixodes scapularis and other arbovirus vector genomes
        date: 2019-06-18
       words: 9015
      flesch: 45
     summary: I. scapularis NIRVS are enriched in bunya- and orthomyxo-like sequences, reflecting that ticks are a dominant host for these virus groups. Unlike in mosquitoes, I. scapularis NIRVS are more commonly derived from the non-structural region (replicase) of negative-sense viruses, as opposed to structural regions (e.g. glycoprotein).
    keywords: aegypti; et al; fig; genome; like; nirvs; pirna; rna; scapularis; sequences; table; tick; viruses
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        item: #14 of 156
          id: cord-003899-a4w2nnos
      author: Yang, Jiwen
       title: Dietary 25-Hydroxyvitamin D(3) Supplementation Alleviates Porcine Epidemic Diarrhea Virus Infection by Improving Intestinal Structure and Immune Response in Weaned Pigs
        date: 2019-08-29
       words: 3817
      flesch: 42
     summary: Porcine epidemic diarrhea virus induces caspase-independent apoptosis through activation of mitochondrial apoptosis-inducing factor Porcine epidemic diarrhea virus infection: Etiology, epidemiology, pathogenesis and immunoprophylaxis Effects of porcine epidemic diarrhea virus infection on nursery pig intestinal function and barrier integrity Immunohistochemical detection of the vomiting-inducing monoamine neurotransmitter serotonin and enterochromaffin cells in the intestines of conventional or gnotobiotic (Gn) pigs infected with porcine epidemic diarrhea virus (PEDV) and serum cytokine responses of Gn pigs to acute PEDV infection Differential gene modulation of pattern-recognition receptor TLR and RIG-I-like and downstream mediators on intestinal mucosa of pigs infected with PEDV non S-INDEL and PEDV S-INDEL strains Outbreak of porcine epidemic diarrhea in suckling piglets Porcine epidemic diarrhea virus: We found that high dose 25-hydroxyvitamin D(3) supplementation could ease intestinal injury and inhibit intestinal immune response induced by porcine epidemic diarrhea virus (PEDV), suggesting that feeding a high dose of 25-hydroxyvitamin D(3) could be used as an approach against PEDV infection.
    keywords: 25(oh)d; challenge; con; diarrhea; expression; infection; pedv; pigs; supplementation; virus
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        item: #15 of 156
          id: cord-004016-iaktm72a
      author: Soto-Quintero, Albanelly
       title: Curcumin to Promote the Synthesis of Silver NPs and their Self-Assembly with a Thermoresponsive Polymer in Core-Shell Nanohybrids
        date: 2019-12-03
       words: 6448
      flesch: 41
     summary: Then, in the regime of low curcumin concentration, phase separation can take place, being the smallest spherical cores produced by sodium citrate and the almost rod-like AgNPs promoted by curcumin. key: cord-004016-iaktm72a authors: Soto-Quintero, Albanelly; Guarrotxena, Nekane; García, Olga; Quijada-Garrido, Isabel title: Curcumin to Promote the Synthesis of Silver NPs and their Self-Assembly with a Thermoresponsive Polymer in Core-Shell Nanohybrids date: 2019-12-03 journal: Sci Rep DOI: 10.1038/s41598-019-54752-4 sha: doc_id: 4016 cord_uid: iaktm72a This work presents a simple one-pot protocol to achieve core-doped shell nanohybrids comprising silver nanoparticles, curcumin and thermoresponsive polymeric shell taking advantage of the reducing properties of phenolic curcumin substance and its ability to decorate metallic surfaces.
    keywords: ag@cur; core; curcumin; fig; hybrid; nanogels; nps; p(meo; polymer; shell; silver; table; temperature
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        item: #16 of 156
          id: cord-004096-obrq7q57
      author: Benghanem, Sarah
       title: Brainstem dysfunction in critically ill patients
        date: 2020-01-06
       words: 5812
      flesch: 31
     summary: Opioids might also contribute to brainstem dysfunction, as they depress the ARAS, respiratory centers, and brainstem reflexes (notably pupillary light and cough reflexes). key: cord-004096-obrq7q57 authors: Benghanem, Sarah; Mazeraud, Aurélien; Azabou, Eric; Chhor, Vibol; Shinotsuka, Cassia Righy; Claassen, Jan; Rohaut, Benjamin; Sharshar, Tarek title: Brainstem dysfunction in critically ill patients date: 2020-01-06 journal: Crit Care DOI: 10.1186/s13054-019-2718-9 sha: doc_id: 4096 cord_uid: obrq7q57 The brainstem conveys sensory and motor inputs between the spinal cord and the brain, and contains nuclei of the cranial nerves.
    keywords: brainstem; consciousness; dysfunction; illness; impairment; inflammatory; lesions; mortality; motor; nerve; nuclei; patients; reflexes; table
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        item: #17 of 156
          id: cord-005460-ezrn8cva
      author: None
       title: Physicians – Poster Session
        date: 2017-07-28
       words: 287532
      flesch: 53
     summary: After three months of treatment patient showed an increase in T cells count (CD3, 411/mmc), and a decrease of toxic metabolites: AXP, 1.652 micromol/ml RBC; dAXP, 0.011 micromol/ml RBC; %dAXP, 0.7 maternal T-cell engraftment persists, despite a good response to the PEG-ADA therapy. Moreover, caspases pathway was significantly activated in thawing CD3+, CD56+ and CD14 + cells: FLICA+ cells % in thawing cells were, respectively, 16.8%, 31.1% and 6.2% vs 3%, 9.7% and o1% in fresh cells.
    keywords: acute gvhd; adult patients; age; aim; allogeneic; allogeneic hsct; aml patients; analysis; anti; asct; associated; atg; autologous; based; beam; blood; blood cell; blood stem; bone; busulfan; cases; cause; cd34; cell count; cell disease; cell dose; cell lymphoma; cell source; cell therapy; cell transplantation; cells; center; chemotherapy; children; chimerism; chronic gvhd; clinical; cmv; cohort; collection; complete; complications; conditioning; conditioning regimen; conflict; consecutive; control; cord; count; cr patients; criteria; csf; cyclophosphamide; data; days; death; development; diagnosis; difference; disclosure; disease; disease relapse; disease risk; dli; donor; donor cell; donor hsct; dose; early; ebv; ecp; effect; efficacy; engraftment; experience; factors; failure; female; figure; fludarabine; follow; following; free; function; grade; graft; group; group patients; gvhd; gvhd grade; gvhd patients; gvhd prophylaxis; haploidentical; hct; hematology; hematopoietic; high; hla; hospital; host disease; hr =; hsct patients; hsct recipients; iii; immune; impact; incidence; increase; induction; infection; infusion; intensity; interest; leukemia patients; levels; line; lymphoma patients; major; male; malignancies; marrow; marrow transplantation; matched; mds patients; mean; median; median follow; median os; melphalan; mobilization; months; mortality; mrd; mud; myeloablative; myeloid; myeloma patients; n =; negative; neutrophil; nk cell; non; nrm; number; outcome; overall; p =; patients; patients characteristics; patients relapse; pbsc; pediatric; period; pfs; platelet; population; positive; post; post hsct; post transplant; potential; pre; primary; prior; procedure; progression; pts; range; rate; reactivation; receiving; recipients; recovery; refractory; regimen; relapse; related; remission; report; respectively; response; results; ric; risk group; risk patients; score; second; secondary; setting; severe; sibling; significant; specific; standard; status; stem cell; steroid; studies; study; survival; syndrome; t cell; table; tbi; term; therapy; time; tma patients; total; toxicity; transplant patients; transplanted; treatment; trm; type; underwent; university; unrelated; use; versus; vod; years
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        item: #18 of 156
          id: cord-005497-w81ysjf9
      author: None
       title: 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020
        date: 2020-03-24
       words: 103795
      flesch: 50
     summary: Conclusions: This is one of the first studies to demonstrate that abnormal RV function is associated with an increased mortality in ICU patients with pneumonia. The fast efficacy of targeted therapies led some intensivists to use them as rescue therapy for ICU patients.
    keywords: acute; administration; admission; adult patients; age; aim; aki; aki patients; analysis; approach; arrest; arterial; associated; association; average; baseline; blood; cardiac; care; care patients; care unit; cases; clinical; cohort; cohort study; complications; control; critical; critical care; data; day mortality; days; death; delirium; difference; discharge; disease; early; ecmo; effect; emergency; factors; failure; figure; fluid; function; group; hospital; hospital mortality; hours; icu admission; icu mortality; icu patients; icu stay; ill; incidence; increase; index; infection; injury; intensive; introduction; length; levels; low; lps; lung; management; mean; median; medical; methods; min; model; months; mortality; non; number; observational; organ; outcome; pain; parameters; patients; period; plasma; population; positive; post; pressure; rate; renal; results; risk; score; sepsis; sepsis patients; septic; serum; shock; shock patients; sofa; stay; studies; study; support; surgery; survival; table; test; therapy; time; total; treatment; unit; university; use; value; ventilation; volume; years
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        item: #19 of 156
          id: cord-006984-x1r99rlm
      author: Yokhana, J. S.
       title: Effect of insoluble fiber supplementation applied at different ages on digestive organ weight and digestive enzymes of layer-strain poultry
        date: 2015-11-14
       words: 7467
      flesch: 50
     summary: At wk 5, the relative proventricular weight (0.41 g/100g BW) and activities of pepsin (75.3 pepsin units/g proventriculus/min) and pancreatic general proteolytic activity (GP) (122.9 μmol tyrosine produced/g tissue) were greater (P < 0.05) than those of Group C (proventricular relative weight, 0.36; pepsin activity, 70.6; GP activity, 94.3). We therefore wished to determine whether there was a correlation between pepsin activity and mRNA in proventricular tissue so as to provide an alternate means of measuring the effects of dietary changes on digestive function.
    keywords: activities; activity; control; diet; experiment; fiber; group; hens; pepsin; pullets; table; tissue
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        item: #20 of 156
          id: cord-007580-qwh8ei60
      author: Knopf, Harry L.S.
       title: Clinical and Immunologic Responses in Patients with Viral Keratoconjunctivitis
        date: 2014-09-26
       words: 5107
      flesch: 49
     summary: A comparison of the percent corneal involvement with fold-rise in antibody titer among patients infected with Group 1 (AV 1) and 2 (AV 2) adenoviruses. key: cord-007580-qwh8ei60 authors: Knopf, Harry L.S.; Hierholzer, John C. title: Clinical and Immunologic Responses in Patients with Viral Keratoconjunctivitis date: 2014-09-26 journal: Am J Ophthalmol DOI: 10.1016/0002-9394(75)90398-0 sha: doc_id: 7580 cord_uid: qwh8ei60 nan Ocular viral infections manifest them selves in a variety of clinical pictures.
    keywords: adenovirus; antibody; corneal; epidemic; group; infections; keratoconjunctivitis; patients; serologic; titer; type
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        item: #21 of 156
          id: cord-009424-0jh0945y
      author: Li, Fufang
       title: Research on covert communication channel based on modulation of common compressed speech codec
        date: 2020-04-13
       words: 5062
      flesch: 45
     summary: At first, the fourth pulse was used as the basis of information hiding, and the amount of hidden information was gradually increased on other pulses in succession. As is shown in Table 9 , taking the fourth pulse position as the basis of hiding information, when each subframe only hides 1 bit of information, the hidden speech quality is about 94.5% of the speech without hidden information, showing that the hiding effect is very good.
    keywords: algorithm; bit; data; embedding; hiding; information; pulse; speech
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        item: #22 of 156
          id: cord-009969-ln91qfg4
      author: Bertolesi, Gabriel E.
       title: Plasticity for colour adaptation in vertebrates explained by the evolution of the genes pomc, pmch and pmchl
        date: 2019-03-10
       words: 9276
      flesch: 40
     summary: In contrast, background adaptation is plastic, with colour change mediated by pigment cell receptors activated by hormones secreted after eye photoperception of surface colour. Although background adaptation occurs in many species, differences exist in the mechanisms between species that are not well understood.
    keywords: a.a; adaptation; background; colour; et al; evolution; figure; fish; gene; group; hormone; mch; mchl; melanin; msh; pituitary; pmch; skin; species
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        item: #23 of 156
          id: cord-010119-t1x9gknd
      author: None
       title: Abstract Presentations from the AABB Annual Meeting San Diego, CA ctober 7‐10, 2017
        date: 2017-09-04
       words: 230433
      flesch: 50
     summary: Probability of occurrence of cannabis metabolites in blood donor samples is likely to be highly variable across donor centers and is largely dependent on blood donor demographics. OBRR, CBER, FDA Background/Case Studies: Extended molecular typing of a large number of blood donors can increase the likelihood of identifying donor red blood cells (RBCs) that match those of the recipient.
    keywords: abo; abo blood; acute; addition; alleles; alloimmunization; analysis; anemia; anti; antibodies; antibody; antigen; apheresis; approach; assay; average; background; bacterial; blood; blood bank; blood cells; blood center; blood collection; blood components; blood count; blood donation; blood donors; blood group; blood loss; blood management; blood order; blood ordering; blood products; blood safety; blood samples; blood screening; blood services; blood specimens; blood supplier; blood supply; blood system; blood testing; blood transfusion; blood type; blood units; blood volume; care; case studies; case study; cases; cd36; cell transfusion; center background; centers; change; clinical; collections; concentration; conclusion; control; cord blood; cost; count; cross; culture; current; data; days; decreased; detection; difference; disease; dna; donations; donor samples; dose; dtt; effect; emergency blood; evaluation; events; evidence; expression; factors; fda; female; ffp; finding; flow; following; frequency; fresh; gel; gene; genotyping; given; groups; hbv; hcv; health; hemoglobin; hemolysis; high; history; hiv; hla; hospital; hospital blood; hospital transfusion; hours; human; identification; igg; immucor; impact; implementation; improvement; incidence; increase; infection; information; initial; institution; inventory; iron; laboratory; levels; low; manual; mean; median; medical; method; mice; minutes; model; molecular; months; mtp; need; negative; new; non; normal; number; order; partial; pathogen; patients; pcr; performance; period; phase; phenotype; plasma; plasma samples; plasma transfusion; plasma units; platelet; platelet blood; platelet transfusion; platelet units; plt; plts; population; positive; post; post transfusion; potential; practice; pre; presence; present; prevalence; procedure; process; processing; program; protocol; quality; r blood; range; rate; rbc; rbc blood; rbc transfusion; rbc units; rbcs; reactive; reactivity; reagent; recipients; recovery; red; reduced; reduction; reference; report; response; results; review; rhd; risk; routine; screening; second; sensitivity; sequencing; serum; set; small; solution; specific; specificity; staff; standard; storage; study design; study period; survey; systems; table; technology; test results; testing; tests; therapy; time; titer; total; tpe; training; transfused; transfusion medicine; transfusion practice; transfusion protocol; transfusion reactions; transfusion results; transfusion service; transfusions; trauma; treatment; tube; typing; units; university; use; values; virus; wastage; wbc; weak; weeks; women; year; zika; zikv
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        item: #24 of 156
          id: cord-011172-1nhvbvy8
      author: Kase, Samuel M.
       title: A pilot study exploring interventions for physician distress in pediatric subspecialists
        date: 2020-02-12
       words: 3906
      flesch: 35
     summary: A systematic review of its definition and measurement Physician burnout-a serious symptom, but of what? The personal and professional consequences of physician burnout: a systematic review of the literature Physicians aren't 'burning out' they're suffering from moral injury A crisis in health care: a call to action on physician burnout Interventions to prevent and reduce physician burnout: a systematic review and meta-analysis Evidence-based interventions for medical student, trainee, and practicing physician well-being: a CHARM annotated bibliography for the Collaborative for Healing and Renewal in Medicine (CHARM) Best Practices Subgroup Physician well-being: expanding the Triple Aim From Triple to Quadruple Aim: care of the patient requires care of the provider Exploring the rewards and challenges of paediatric palliative care work Not all coping strategies are created equal: a mixed methods study exploring physicians' self-reported coping strategies Compassion fatigue, burnout, and compassion satisfaction in neonatologists in the U A cross-sectional analysis of compassion fatigue, burnout, and compassion satisfaction in pediatric palliative care providers in the United States A cross-sectional analysis of compassion fatigue, burnout, and compassion satisfaction in pediatric critical care physicians in the United States A crosssectional analysis of compassion fatigue, burnout, and compassion satisfaction in pediatric emergency medicine physicians in the United States A cross-sectional analysis of compassion fatigue, burnout, and compassion satisfaction in pediatric hematology-oncology physicians in the United States Handbook of Personality: Theory and Research The Mini-IPIP Scales: tinyyet-effective measures of the Big Five Factors of personality Compassion Fatigue: 8, 9 A working definition of physician wellness has been suggested to include not merely the absence of ill-being, but physical and mental well-being that allows physicians to develop their full potentials across personal and work-life domains.
    keywords: activities; burnout; care; institution; physicians; study; support; wellness
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        item: #25 of 156
          id: cord-014597-66vd2mdu
      author: None
       title: Abstracts from the 25th European Society for Animal Cell Technology Meeting: Cell Technologies for Innovative Therapies: Lausanne, Switzerland. 14-17 May 2017
        date: 2018-03-15
       words: 50744
      flesch: 43
     summary: [3] ) -Error frequency does not invalidate use of direct observation methods for cell cloning -Single cell seen by both scientists is highly likely to be monoclonal -During method development, strategies established to control potential sources of error ( Table 1 ) Use of a contemporaneous visualisation approach, a strict control strategy, and a suitable statistical model (which takes into account potential errors) results in: -The CACC method being at least as robust as the LDC method -The CACC method being a reliable, single-step method for cloning to achieve a high P(monoclonality) The main feature of our CI-SCREEN technology is the ability to combine the advantage of cell linesthe unlimited cell supplywith the advantage of primary cellsthe physiological relevance.
    keywords: addition; analysis; antibodies; antibody; approach; background; batch; bioreactor; cell; cell clones; cell culture; cell density; cell growth; cell line; cho; cho cell; clones; concentration; conditions; control; cultivation; cultures; data; day; development; experiments; expression; fed; feed; fig; fold; free; gene; glucose; glycosylation; high; human; increase; integration; levels; lines; mab; media; medium; method; model; number; parameters; performance; perfusion; phase; platform; process; process development; processes; production; productivity; protein; protein production; quality; rate; results; scale; selection; specific; study; system; table; target; therapeutic; time; titer; transfection; use; vector; viability; virus
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        item: #26 of 156
          id: cord-014900-yw088jvf
      author: Li, W. D.
       title: Effect of water deficit on biomass production and accumulation of secondary metabolites in roots of Glycyrrhiza uralensis
        date: 2011-05-05
       words: 1903
      flesch: 51
     summary: Dry weight of the plant and its organs decreased with increasing water deficit, but no effect was exerted at 60-70% WC ( Table 2) . Root dry weight decreased by 2.3, 13.1, and 37.6% with increasing water deficit, while shoot dry weight decreased by 11.9, 24.6, and 46.0%, respectively (Table 2 ).
    keywords: acid; biomass; deficit; drought; plants; roots; water
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        item: #27 of 156
          id: cord-015527-ph576eji
      author: Mostajo, Nelly F
       title: A comprehensive annotation and differential expression analysis of short and long non-coding RNAs in 16 bat genomes
        date: 2019-09-30
       words: 8399
      flesch: 48
     summary: Other ncRNAs are currently unknown from bat genomes or not well documented. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 RNA-Seq gene expression estimation with read mapping uncertainty Rfam: an RNA family database Rfam 13.0: shifting to a genome-centric resource for non-coding RNA families Non-coding RNA analysis using the Rfam database Infernal 1.0: inference of RNA alignments Infernal 1.1: 100-fold faster RNA homology searches RALEE--RNA Alignment editor in Emacs RNAmmer: consistent and rapid annotation of ribosomal RNA genes tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence Matching of Soulmates: coevolution of snoRNAs and their targets Characterisation of novel microRNAs in the Black flying fox (Pteropus alecto) by deep sequencing LNCipedia 5: towards a reference set of human long non-coding RNAs MITOS: Improved de novo metazoan mitochondrial genome annotation A comprehensive study of de novo genome assemblers: current challenges and future prospective Genome-wide signatures of convergent evolution in echolocating mammals A high-resolution map of human evolutionary constraint using 29 mammals Comparative analysis of bat genomes provides insight into the evolution of flight and immunity The genomes of two bat species with long constant frequency echolocation calls Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii Exploring the genome and transcriptome of the cave nectar bat Eonycteris spelaea with PacBio long-read sequencing The Egyptian rousette genome reveals unexpected features of bat antiviral immunity Reference sequence (RefSeq) database at [NCBI: current status, taxonomic expansion, and functional annotation sequencing and annotation for the Jamaican fruit bat (Artibeus jamaicensis)
    keywords: annotated; annotations; assembly; bat; bats; coding; data; gene; genome; mirnas; ncrnas; rna; seq; set; species; table
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        item: #28 of 156
          id: cord-015684-q10sx1dm
      author: Cacabelos, Ramón
       title: Pharmacogenomic Biomarkers in Neuropsychiatry: The Path to Personalized Medicine in Mental Disorders
        date: 2009
       words: 17012
      flesch: 35
     summary: 4th Edn Pharmacogenomics: the inherited basis for interindividual differences in drug response Pharmacogenetics and pharmacogenomics: development, science, and translation Pharmacogenomics and therapeutic prospect in dementia Pharmacogenetic basis for therapeutic optimization in Alzheimer's disease Infl uence of pharmacogenetic factors on Alzheimer's disease therapeutics Pharmacogenetic aspects of therapy with cholinesterase inhibitors: the role of CYP2D6 in Alzheimer's disease pharmacogenetics From pharmacogenetics and ecogenetics to pharmacogenomics Inheritance and drug response Pharmacogenomics-Drug disposition, drug targets, and side effects National estimates of medication use in nursing homes Medicare Current Benefi ciary Survey and the 1996 Medical Expenditure Survey Antidepressant drugs prescribing among elderly subjects: a population-based study Potentially inappropriate medication use among elderly home care patients in Europe Potentially inappropriate medication use by elderly persons in U.S. Health Maintenance Organizations The Metabolic & Molecular Bases of Inherited Disease Catalog of 680 variants among eight cytochrome P450 (CYP) genes: nine esterase genes, and two other genes in the Japanese population DNA sequence variations in a 3.7-kb noncoding sequence 5-prime of the CYP1A2 gene: implications for human population history and natural selection PM frequencies of major CYPs in Asians and Caucasians Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population CYP2C9 allelic variants: ethnic distribution and functional signifi cance Identifi cation and functional characterization of a new CYP2C9 variant (CYP2C9 * 5 1 ) expressed among African Americans Molecular basis of ethnic differences in drug disposition and response Isolation, sequence and genotyping of the drug metabolizer CYP2D6 gene in the Colombian population Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes Cytochrome P450 in the brain: a review The expression of CYP2B6, CYP2C9 and CYP2A4 genes: a tangle of networks of nuclear and steroid receptors Regulation of cytochrome P450 (CYP) genes by nuclear receptors The CYP2C19 enzyme polymorphism Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences Clinically signifi cant drug interactions with cholinesterase inhibitors: a guide for neurologists Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population Ten percent of North Spanish individuals carry duplicated or triplicated CYP2D6 genes associated with ultrarapid metabolism of debrisoquine Clinical pharmacokinetics of galantamine Impact of the CYP2D6 polymorphism on steady-state plasma concentrations and clinical outcome of donepezil in Alzheimer's disease patients Molecular pathology and pharmacogenomics in Alzheimer's disease: polygenic-related effects of multifactorial treatments on cognition, anxiety, and depression Pharmacogenomic studies with a combination therapy in Alzheimer's disease Interethnic differences in genetic polymorphisms of CYP2D6 in the U.S. population: clinical implications Donepezil use in Alzheimer disease Effects of cholinergic markers in rat brain and blood after short and prolonged administration of donepezil Treatment with MPEP and MTEP can induce gene expression related to ATP synthesis, hydrolase activity, and signaling pathways associated with mitogen-activated protein kinase (MAPK) in the frontal cortex, this constituting another potential therapeutic target in some neuropsychiatric disorders.
    keywords: activity; alzheimer; apoe; brain; carriers; cns; cyp2d6; dementia; disease; disorders; drug; enzymes; expression; factors; genes; genotype; infl; levels; metabolism; patients; pharmacogenomics; pms; profi; receptor; response; schizophrenia; studies; treatment; ums; variants
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        item: #29 of 156
          id: cord-016308-qzkcwrit
      author: Cochran, Christina L.
       title: Neonatal Emergencies
        date: 2015-11-06
       words: 2767
      flesch: 41
     summary: -Risk factors for infection include prolonged rupture of membranes, maternal fever, maternal infection, and lack of appropriate treatment for maternal GBS. • Prevention of hyperbilirubinemia focuses on appropriate hydration of the newborn and appropriate treatment of maternal infections at the time of delivery.
    keywords: blood; history; hyperbilirubinemia; infection; maternal; neonatal; newborns; patients; table
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        item: #30 of 156
          id: cord-017184-1ewi3dka
      author: None
       title: Primary Immunodeficiencies
        date: 2008
       words: 44590
      flesch: 43
     summary: Therefore defects in BM prethymic T cell development can contribute to T cell deficiency in nu/nu mice [90] . T-cell proliferative responses to mitogens were defective and IL 2 R expression was deficient on his T lymphocytes, and B cells did not differentiate into antibodysecreting cells when provided with the help of normal T cells [245] .
    keywords: absence; age; b cells; bmt; bone; cases; cd8; cells; children; chromosome; chronic; class; clinical; combined; common; defect; deficiencies; deficiency; development; diagnosis; disease; expression; fig; function; gene; hla; ifn; iga; ige; igg; igm; immunodeficiency; infections; levels; life; lymphocyte; marrow; months; mutations; normal; patients; pid; present; primary; production; protein; recurrent; rris; scid; serum; severe; study; symptoms; syndrome; t cells; table; transplantation; treatment; years
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        item: #31 of 156
          id: cord-017367-15o6g57q
      author: Polychronakis, Ioannis
       title: Workplace Health Promotion Interventions ConcerningWomenWorkers' Occupational Hazards
        date: 2008
       words: 10563
      flesch: 18
     summary: Int Arch Occup Environ Health Williams NR (2003) Occupational groups at risk of voice disorders: A review of the literature Chemical occupational risks identified by nurses in a hospital environment Work-related musculoskeletal disorders and associated factors in teachers of physically and intellectually disabled pupils: A self-administered questionnaire study Seroprevalence of varicella, measles and hepatitis B among female health care workers of childbearing age Immunization and Child Health Materials Development Guide Zidkova Z and Martinkova J (2003) Psychic load in teachers of elementary schools As a consequence, women workers are more easily affected by burnout effect or suffer more frequently from work-related stress than their male colleagues, who continue to participate significantly less than women in house tasks.
    keywords: chemical; disorders; employees; et al; exposure; factors; female; gender; hazards; health; issues; job; population; prevention; program; reproductive; risk; safety; table; tasks; whp; women; women workers; workers; working; workplace
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        item: #32 of 156
          id: cord-017499-51yy7y9n
      author: Freye, Enno
       title: Mechanism of Action of Opioids and Clinical Effects
        date: 2008
       words: 24978
      flesch: 42
     summary: It is assumed that opioid receptors mediate Opioid receptors are found in several areas of the brain, particularly in the periaqueductal grey matter, and throughout the spinal cord ( Figure II-9 ). There, opioids act as agonists at highly definite receptor sites, and there is general agreement on the existence of at least three types of opioid receptor sites (Table II-1).
    keywords: action; activity; addition; affinity; agonist; analgesic; anesthesia; antagonist; binding; brain; cough; depression; dose; drug; effect; fentanyl; figure; following; heroin; increase; morphine; naloxone; nerve; nucleus; opioid; opioid receptor; opium; pain; patients; potency; potent; receptor; response; results; sites; solution; sufentanil; system; use
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        item: #33 of 156
          id: cord-018884-os0faovj
      author: Peghin, Maddalena
       title: Prevention and Treatment of Respiratory Virus Infection
        date: 2019-03-01
       words: 5433
      flesch: 31
     summary: Key points for RV infections in SOT Epidemiology and clinical presentation � There is increasing recognition of infections caused by RVs as a major cause of morbidity and mortality in SOT � In addition to their direct, cytopathic, and tissue-invasive effects, RVs can create a microbially determined immune modulation The impact of RVs in acute and chronic rejection remains controversial, with the greatest risk in lung transplant recipients � Pediatric solid organ, lung transplant, and heart-lung transplantation recipients appear to have the greatest risk of both RVs infections and more severe complications � Rhinovirus and coronaviruses are the most common etiological agents � Influenza and other paramyxovirus (RSV, PIV, and hMPV) have a greater propensity to produce LRTID Diagnosis � Diligent collection of respiratory specimens and knowledge of the limitations of the assay used by your laboratory are essential for interpreting the results � Nasopharyngeal swabs (NPS) are preferred for the detection of all major RVs � Bronchoalveolar lavage is the preferred specimen for diagnostic testing in LRTID with negative NPS � Laboratory diagnostic methods include virus culture, rapid antigen detection tests, the reverse-transcriptase polymerase chain reaction (RT-PCR) and other nucleic acid amplification assays, and serology � Nucleic acid amplification tests, mainly RT-PCR, are the best diagnostic tools for studying RVs in SOT Treatment � Treatment options remain limited and consist of supportive care, reduction of immunosuppression and, if available, antiviral therapy � The use of immunomodulatory agents (intravenous immunoglobulin, monoclonal antibodies, RV-specific T lymphocytes or augmented corticosteroid therapy) is a clinical dilemma � SOT should receive antiviral therapy with a neuraminidase inhibitor (NAI, either oseltamivir or zanamivir) when influenza is suspected, before laboratory confirmation � Treatment of influenza with M2 inhibitors (amantadine and rimantadine) is not recommended for high resistance rates � Treatment for influenza with NAI should be initiated as soon as possible (<48 h) for optimal benefit, however and all symptomatic patients should receive antiviral therapy, irrespective of symptom onset � Duration of therapy should be minimum of 5 days, but longer duration of therapy (�10 days) may be required in critically ill patients � Double dosing of oseltamivir is not recommended but may be considered in severe cases or in case of insufficient response to therapy � The use of intravenous zanamivir or peramivir can be considered in patients not responding to oseltamivir therapy or for whom oral absorption is a concern � In case of high-level oseltamivir resistance, zanamivir is usually active � The efficacy of ribavirin (aerosolized, intravenous, or oral) for the treatment of RSV infection in SOT recipients has not been determined � In severe cases of LRTIs with RSV, PIV, and hMPV infections in SOT recipients, therapy with ribavirin (aerosolized, intravenous, or oral) may be used, alone or in combination with an immunomodulatory agents Prevention � Maximizing prevention infection control measures against RVs in SOT is mandatory � SOT recipients should avoid close contact with individuals with respiratory tract infections � The main preventive strategy against influenza remains the administration of yearly trivalent inactivated influenza vaccine in all SOT recipients and their relatives � Influenza vaccination is safe in SOT recipients, even in the early posttransplant period � Oseltamivir may be used as pre-exposure and postexposure prophylaxis in selected patients � The use of palivizumab for prevention of RSV infection is not recommended in adult SOT recipients FLU influenza, hMPV human metapneumovirus, LRTID lower respiratory tract infectious disease, NPS nasopharyngeal swab, PIV parainfluenza, RBV ribavirin, RSV respiratory syncytial virus, RVs respiratory viruses, SOT solid organ transplant Table 9 .5 (continued) Influenza and other respiratory virus infections in solid organ transplant recipients Epidemiology and immediate indirect effects of respiratory viruses in lung transplant recipients: a 5-year prospective study Incidence and outcomes of respiratory viral infections in lung transplant recipients: a prospective study Respiratory viral infections in pediatric solid organ and hematopoietic stem cell transplantation Respiratory viruses in lung transplant recipients: a critical review and pooled analysis of clinical studies From the classic concepts to modern practice RNA respiratory viruses in solid organ transplantation Nasopharyngeal viral PCR in immunosuppressed patients and its association with virus detection in bronchoalveolar lavage by PCR Respiratory virus detection in immunocompromised patients with FilmArray respiratory panel compared to conventional methods Antiviral agents for the treatment and chemoprophylaxis of influenza -recommendations of the Advisory Committee on Immunization Practices (ACIP) Respiratory viral infections are typically caused by rhinovirus (RhVs), coronavirus (CoV), respiratory syncytial virus (RSV), influenza (FLU), parainfluenza (PIV), human metapneumovirus (hMPV), and adenovirus (AdV) ( Table 9 .1).
    keywords: infections; influenza; lung; patients; recipients; rvs; sot; transplant; treatment
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        item: #34 of 156
          id: cord-021013-xvc791wx
      author: Wink, Michael
       title: Chapter 1 Allelochemical Properties or the Raison D'être of Alkaloids
        date: 2008-05-30
       words: 16169
      flesch: 45
     summary: In a number of plants alkaloids are translocated via the phloem (511). The ingestion of a number of allelochemicals such as emetine, lobeline, morphine, and many other alkaloids causes these symptoms (312).
    keywords: activities; activity; alkaloids; allelochemicals; animals; cells; chemical; compounds; data; defense; effects; food; fungi; herbivores; host; insects; lupines; mechanisms; metabolites; molecules; number; plants; present; products; properties; species; table
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        item: #35 of 156
          id: cord-021951-xxvol17t
      author: Amos, Louella B.
       title: Cough
        date: 2017-05-12
       words: 11898
      flesch: 45
     summary: False-negative results of sweat tests can be seen in CF children presenting with edema or hypoproteinemia and in samples from children with an inadequate sweat rate. Similarly pansinusitis is nearly universal among CF patients but is quite uncommon in other children.
    keywords: age; airway; aspiration; asthma; bronchiolitis; cases; cause; chest; children; cough; diagnosis; disease; hemoptysis; infants; infection; lung; patients; pneumonia; table; treatment
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        item: #36 of 156
          id: cord-022147-istz1iql
      author: None
       title: Procedures to Investigate Waterborne Illness
        date: 2016-07-13
       words: 38236
      flesch: 47
     summary: Collecting clinical samples and water samples • Conducting an on-site investigation at the facility alleged to be responsible to determine the mode of contamination or process failure, e.g., low disinfectant level • Characterizing the etiologic agents by laboratory analysis using various typing schemes. Instruct the ill person to hold all clinical specimens and water samples until the health agency evaluates the epidemiological evidence and arranges, if necessary, to collect them.
    keywords: agencies; agent; cases; chlorine; coli; contact; contamination; data; disease; disinfectant; distribution; drinking water; example; exposure; health; illness; incubation; information; investigation; laboratory; non; number; outbreak; pathogens; period; persons; public; records; results; risk; samples; source; specimens; symptoms; system; table; test; time; use; value; water; water samples; water source; water supply; water treatment; waterborne; waterborne illness
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        item: #37 of 156
          id: cord-022281-xn0cf33a
      author: Tanz, Robert R.
       title: Sore Throat
        date: 2009-05-15
       words: 5736
      flesch: 38
     summary: There have been outbreaks of group G streptococcal pharyngitis among children. Acute rheumatic fever is not a sequela to these infections, although post-streptococcal acute glomerulonephritis has been documented in rare cases after epidemic group C and group G streptococcal pharyngitis.
    keywords: acute; children; culture; fever; group; infection; patients; penicillin; pharyngitis; streptococcal; throat; treatment
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        item: #38 of 156
          id: cord-022292-msz4au4b
      author: Gershan, William M.
       title: Cough
        date: 2009-05-15
       words: 13127
      flesch: 45
     summary: False-negative results of sweat tests can be seen in CF children presenting with edema or hypoproteinemia and in samples from children with an inadequate sweat rate. Similarly, pansinusitis is nearly universal among CF patients but is quite uncommon in other children.
    keywords: airway; aspiration; asthma; blood; bronchoscopy; cases; cause; chest; child; children; cough; diagnosis; disease; infants; infection; lung; patients; pneumonia; pulmonary; table; treatment
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        item: #39 of 156
          id: cord-022380-49oti4zg
      author: Panlilio, Adelisa L
       title: Occupational Infectious Diseases
        date: 2009-05-15
       words: 15593
      flesch: 39
     summary: To the extent that unsafe practices have been defined, and practice policies modified to reduce infection risk, continued transmission often represents failure to follow accepted standards. Recognition of the types of infection risk associated with specific occupations can, in most cases, lead to effective, often simple steps for primary prevention, as well as opportunities for early diagnosis and treatment.
    keywords: adults; blood; children; contact; control; days; disease; exposure; hcv; healthcare; hepatitis; hiv; immunization; infection; influenza; patients; personnel; persons; risk; transmission; treatment; vaccine; virus; workers
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        item: #40 of 156
          id: cord-022642-f784qdr5
      author: MAY, VALERIE
       title: A subtidal transect in Jervis Bay, New South Wales
        date: 2006-07-28
       words: 4422
      flesch: 60
     summary: They were both unevenly distributed and intermixed with patches of other large algae such as Sargassum spp. The next station of the transect (Station B), a horizontal shelf, had a uniform turf flora ( Fig. 2) with no large plants of E. radiata, P. comosa or Sargassum spp.; breaking wave action at this site seems to have been too severe for large algae.
    keywords: algae; changes; comosa; radiata; species; station; storms; study; table; transect
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        item: #41 of 156
          id: cord-024981-yfuuirnw
      author: Severin, Paul N.
       title: Types of Disasters
        date: 2020-05-14
       words: 29279
      flesch: 45
     summary: There appears to be a similar aging process as seen with other nerve agents. However, other nerve agent incidents, such as the 1995 Tokyo subway attack (sarin), the chemical attacks in Syria (chlorine, sarin, mustard), and the attempted assassination of Sergei Skripal in Salisbury, UK (Novichok), support that civilian threats also exist.
    keywords: agents; air; anthrax; blast; care; chemical; children; community; days; decontamination; department; disaster; disease; dose; education; emergency; event; exposure; fever; health; high; homeland; incidents; injuries; injury; management; mass; medical; national; nerve; patients; pediatric; people; plague; planning; preparedness; radiation; response; risk; school; security; shooter; shooting; states; students; system; terrorism; treatment; united; use; vaccine; victims
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        item: #42 of 156
          id: cord-025300-sl9kredk
      author: Jiménez-Ruiz, Ernesto
       title: SemTab 2019: Resources to Benchmark Tabular Data to Knowledge Graph Matching Systems
        date: 2020-05-07
       words: 6253
      flesch: 58
     summary: Results of the ontology alignment evaluation initiative DAGOBAH: an end-to-end context-free tabular data semantic annotation system AIcrowd Evaluation Codes Learning semantic annotations for tabular data ColNet: embedding the semantics of web tables for column type prediction MantisTable: an automatic approach for the semantic table interpretation OpenTapioca: lightweight entity linking for Wikidata Matching web tables with knowledge base entities: from entity lookups to entity embeddings Annotating web tables through ontology matching Ontology matching benchmarks: generation, stability, and discriminability Ontology Matching Semantic Web Challenge on Tabular Data to Knowledge Graph Matching SemTab2019: Semantic Web Challenge on Tabular Data to Knowledge Graph Matching -2019 Data Sets The merge/purge problem for large databases VizNet: towards a large-scale visualization learning and benchmarking repository Sherlock: a deep learning approach to semantic data type detection LogMap: logic-based and scalable ontology matching Making sense of numerical data -semantic labelling of web tables A large public corpus of web tables containing time and context metadata Annotating and searching web tables using entities, types and relationships DBpedia spotlight: shedding light on the web of documents Loupe -an online tool for inspecting datasets in the linked data cloud Semantic table interpretation using LOD4ALL MTab: matching tabular data to knowledge graph using probability models ADOG -anotating data with ontologies and graphs Matching HTML Tables to DBpedia CSV2KG: transforming tabular data into semantic knowledge Entity linking to knowledge graphs to infer column types and properties Effective and efficient semantic table interpretation using tableminer+ We would like to thank the challenge participants, the ISWC & OM organisers, the AIcrowd team, and our sponsors (SIRIUS and IBM Research) that played a key role in the success of SemTab. The addition of semantic information to Web tables may enhance a wide range of applications, such as web search, question answering, and knowledge base construction.
    keywords: challenge; class; column; data; dbpedia; evaluation; matching; semantic; systems; table; tabular
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        item: #43 of 156
          id: cord-026009-rdhuc2n2
      author: Anderson, Nancy L.
       title: Pet Rodents
        date: 2009-05-15
       words: 14928
      flesch: 56
     summary: • Diagnosis is based on clinical signs, history, visualization of parasite, skin scrape, and cellophane tape test. • Clinical signs include erythema, pruritus, waxy debris, and excoriations behind the ears.
    keywords: animals; cage; cause; chinchillas; common; culture; diagnosis; diarrhea; disease; examination; guinea; hamsters; infection; male; mice; pet; pigs; prognosis; rats; results; rodents; signs; skin; table; treat; treatment; tube; use
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        item: #44 of 156
          id: cord-026031-hnf5vayd
      author: Ford, Richard B.
       title: Emergency Care
        date: 2009-05-21
       words: 112481
      flesch: 42
     summary: animal patients. The normal CVP for small animal patients is 0 to 5 cm H 2 O. Values less than zero are associated with absolute or relative hypovolemia.
    keywords: abnormalities; acute; administer; administration; airway; animal; bandage; blood; blood pressure; body; cardiac; care; cases; catheter; cats; cause; charcoal; control; crystalloid; damage; days; decrease; diagnosis; disease; dogs; dose; drugs; dysrhythmias; edema; effects; effusion; emergency; emesis; examination; exposure; failure; fluid; following; function; gastrointestinal; heart; hemorrhage; hours; infection; ingestion; injury; intravenous; kg iv; kg po; lavage; loss; management; minutes; monitor; needle; normal; obstruction; occurs; oxygen; pain; patient; perform; perfusion; place; plasma; presence; present; pressure; pulmonary; radiographs; rate; renal; result; risk; saline; secondary; seizures; serum; shock; signs; skin; sodium; solution; supplemental; therapy; thoracic; time; tissue; toxicity; trauma; treatment; tube; urine; volume; vomiting; water; wound
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        item: #45 of 156
          id: cord-028751-71bf4w44
      author: Betten, Anton
       title: Classifying Simplicial Dissections of Convex Polyhedra with Symmetry
        date: 2020-06-06
       words: 1768
      flesch: 59
     summary: For computing dissections of a polyhedron P with automorphism group G, let P be the set of partial dissections. The number of equivalence classes of simplicial dissections of the cube under its automorphism group of order 48 is exactly 10.
    keywords: dissections; number; objects; table
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        item: #46 of 156
          id: cord-029462-jm5qwxhz
      author: Ouidir, Marion
       title: Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation
        date: 2020-07-13
       words: 6387
      flesch: 38
     summary: Environmental chemicals in pregnant women in the United States: NHANES Prenatal exposure to endocrine disrupting chemicals and risk of being born small for gestational age: pooled analysis of seven European birth cohorts The transfer of polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs) across the human placenta and into maternal milk Transport of persistent organic pollutants across the human placenta Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth: a systematic review Prenatal exposure to perfluoroalkyl substances and birth outcomes in a Spanish birth cohort Prenatal exposure to polychlorinated biphenyls and fetal growth in British girls Endocrine disruptors and neonatal anthropometry Association of maternal exposure to persistent organic pollutants in early pregnancy with fetal growth Early-life exposure to persistent organic pollutants (OCPs, PBDEs, PCBs, PFASs) and attention-deficit/hyperactivity disorder: a multi-pollutant analysis of a Norwegian birth cohort Serum PBDEs and age at menarche in adolescent girls: analysis of the National Health and Nutrition Examination Survey Prenatal exposure to persistent organic pollutants and anogenital distance in children at 18 months Morphologic and molecular changes in the placenta: what we can learn from environmental exposures Bisphenol A affects placental layers morphology and angiogenesis during early pregnancy phase in mice Effects of estradiol administration on feto-placental growth in rat Associations between in utero exposure to polybrominated diphenyl ethers, pathophysiological state of fetal growth and placental DNA methylation changes Prenatal exposure to persistent organic pollutants and methylation of LINE-1 and imprinted genes in placenta: a CHECK cohort study Maternal exposures to persistent organic pollutants are associated with DNA methylation of thyroid hormone-related genes in placenta differently by infant sex In utero exposures to environmental organic pollutants disrupt epigenetic marks linked to fetoplacental development Umbilical cord blood PBDEs concentrations are associated with placental DNA methylation Genetic variants influence on the placenta regulatory landscape Mechanisms and disease associations of haplotype-dependent allele-specific DNA methylation Systematic identification of genetic influences on methylation across the human life course Exposure to polybrominated biphenyl (PBB) associates with genome-wide DNA methylation differences in peripheral blood DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia An epigenome-wide study of cord blood DNA methylations in relation to prenatal perfluoroalkyl substance exposure: the Hokkaido study Leveraging polygenic functional enrichment to improve GWAS power Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry Whole-genome sequencing coupled to imputation discovers genetic signals for anthropometric traits Dissection of genetic variation and evidence for pleiotropy in male pattern baldness Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients Occupational exposure to endocrine-disrupting chemicals and birth weight and length of gestation: a European meta-analysis Exposure to 2,2',4,4'-tetrabromodiphenyl ether at late gestation modulates placental signaling molecules in the mouse model Diagnostic utility of genome-wide DNA methylation testing in genetically unsolved individuals with suspected hereditary conditions Biallelic mutations in MYORG cause autosomal recessive primary familial brain calcification Evaluation of MYORG mutations as a novel cause of primary familial brain calcification DNA methylation loci in placenta associated with birthweight and expression of genes relevant for early development and adult diseases Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals Sex differences in the genetic architecture of obsessive-compulsive disorder Genome-wide association study of paliperidone efficacy Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes Prenatal concentrations of perfluoroalkyl substances and bone health in British girls at age 17 Effects of developmental exposure to perfluorooctanoic acid (PFOA) on long bone morphology and bone cell differentiation Accounting for population stratification in DNA methylation studies An epigenome-wide association study of obesity-related traits Controlling bias and inflation in epigenome-and transcriptome-wide association studies using the empirical null distribution Cohort profile: NICHD fetal growth studies-singletons and twins Calculation of serum total lipid concentrations for the adjustment of persistent organohalogen toxicant measurements in human samples Chlorinated hydrocarbon levels in human serum: effects of fasting and feeding Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: a longitudinal study The limitations due to exposure detection limits for regression models Sex differences in the associations of placental epigenetic aging with fetal growth DNA methylation age of human tissues and cell types Salmon provides fast and bias-aware quantification of transcript expression limma powers differential expression analyses for RNA-sequencing and microarray studies methylKit: a comprehensive R package for the analysis of genomewide DNA methylation profiles Capturing heterogeneity in gene expression studies by surrogate variable analysis sva: surrogate variable analysis. Placental epigenetic mechanisms may be involved, but no prior epigenome-wide studies have investigated the impact of maternal POPs on placental DNA methylation.
    keywords: analysis; cpg; cpg sites; dna; expression; methylation; placental; plasma; pops; sites; study; table; value
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        item: #47 of 156
          id: cord-031330-zgzq35fe
      author: Kumar, Durgesh
       title: In-silico prediction of novel drug-target complex of nsp3 of CHIKV through molecular dynamic simulation
        date: 2020-08-24
       words: 5117
      flesch: 48
     summary: MD trajectories were studied to collect the information about the nsp3 of CHIKV with and without screened compound and then, MM-GBSA calculations were performed to calculate change in binding free energies for the formation of complex. In this protocol, Method A (Protein-Ligand Complex) was used to estimation of binding free energy and these molecules are listed in Table 2 .
    keywords: binding; chikv; complex; compounds; drug; energy; molecules; nsp3; simulations; table; target
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        item: #48 of 156
          id: cord-031416-ytbs95wi
      author: Sabzpoushan, S. H.
       title: A System Biology-Based Approach for Designing Combination Therapy in Cancer Precision Medicine
        date: 2020-08-26
       words: 9622
      flesch: 45
     summary: The recognition that cancer cells need their microenvironment to efficiently display their phenotype has opened the door to hypothesize and implement new therapeutic strategies. The trastuzumab moiety of this ADC binds to HER2 on tumor cell surfaces; upon internalization, the DM1 moiety is released and binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation of cancer cells that overexpress HER2.
    keywords: absm; age; agents; cancer; cells; combination; growth; na_1; number; players; system; table; therapies; therapy; tumor
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        item: #49 of 156
          id: cord-032174-qu5mm9r1
      author: Xu, Zhonglin
       title: Sampling Theory
        date: 2013-08-14
       words: 11559
      flesch: 66
     summary: Sampling is generally divided into the planktonic method (the airborne state of sampled particles remains the same) and the capture method (airborne particles are captured). So in the above circumstances, it may not be necessary to use large sampling flow rate particle counter.
    keywords: air; concentration; flow rate; loss; particle; rate; sampling; sampling flow; sampling tube; sampling volume
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        item: #50 of 156
          id: cord-032491-tycd2i95
      author: Severino, Amie L.
       title: μ-Opioid Receptors on Distinct Neuronal Populations Mediate Different Aspects of Opioid Reward-Related Behaviors
        date: 2020-09-18
       words: 7905
      flesch: 44
     summary: Mu opioid receptors in gamma-aminobutyric acidergic forebrain neurons moderate motivation for heroin and palatable food Dopaminergic regulation of striatal interneurons in reward and addiction: focus on alcohol Optogenetic self-stimulation in the nucleus accumbens: D1 reward versus D2 ambivalence Targeted expression of m-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward Expression of mu opioid receptor mRNA in rat brain: an in situ hybridization study at the single cell level Dichotomous effects of mu opioid receptor activation on striatal low-threshold spike interneurons Addictive behaviour in experimental animals: prospects for translation Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatum Expression of mu opioid receptor in dorsal diencephalic conduction system: new insights for the medial habenula D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs Dopamine and opioids inhibit synaptic outputs of the main island of the intercalated neurons of the amygdala Unique contributions of parvalbumin and cholinergic interneurons in organizing striatal networks during movement Specific behavioral and cellular adaptations induced by chronic morphine are reduced by dietary omega-3 polyunsaturated fatty acids Dietary supplementation with omega-3 polyunsaturated fatty acids reduces opioid-seeking behaviors and alters the gut microbiome Phasic dopamine release in the rat nucleus accumbens symmetrically encodes a reward prediction error term Rapid signalling in distinct dopaminergic axons during locomotion and reward Opioid self-administration results in cell-type specific adaptations of striatal medium spiny neurons Loss of BDNF signaling in D1R-expressing NAc neurons enhances morphine reward by reducing GABA inhibition Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry lmerTest package: tests in linear mixed effects models Partial ablation of mu-opioid receptor rich striosomes produces deficits on a motor-skill learning task Reward processing by the opioid system in the brain Regional and cell-type-specific effects of DAMGO on striatal D1 and D2 dopamine receptor-expressing medium-sized spiny neurons Spontaneous synaptic activation of muscarinic receptors by striatal cholinergic neuron firing Locomotor activity predicts acquisition of self-administration behavior but not cocaine intake Beta-arrestin 1 regulation of reward-motivated behaviors and glutamatergic function Roles of micro-opioid receptors in GABAergic synaptic transmission in the striosome and matrix compartments of the striatum Cannabinoid, melanocortin and opioid receptor expression on DRD1 and DRD2 subpopulations in rat striatum Powerful inhibitory action of mu opioid receptors (MOR) on cholinergic interneuron excitability in the dorsal striatum Enhanced mu opioid receptor-dependent opioidergic modulation of striatal cholinergic transmission in DYT1 dystonia The neural basis of drug craving: an incentive-sensitization theory of addiction Anatomy of adenosine A2A receptors in brain: morphological substrates for integration of striatal function Effect of selective opiate antagonists on striatal acetylcholine and dopamine release Mu-opioid receptors in nociceptive afferents produce a sustained suppression of hyperalgesia in chronic pain Reappraising striatal D1-and D2-neurons in reward and aversion Opioid-induced rewards, locomotion, and dopamine activation: a proposed model for control by mesopontine and rostromedial tegmental neurons Tolerance and sensitization to the behavioral effects of drugs Nicotine modifies corticostriatal plasticity and amphetamine rewarding behaviors in mice (1, 2, 3) Heteromers of m opioid and dopamine D1 receptors modulate opioid-induced locomotor sensitization in a dopamine-independent manner Recurrent collateral connections of striatal medium spiny neurons are disrupted in models of Parkinson's disease Rapid dopamine transmission within the nucleus accumbens: dramatic difference between morphine and oxycodone delivery Differential contributions of striatal dopamine D1 and D2 receptors to component processes of value-based decision making Dendritic spines containing m-opioid receptors in rat striatal patches receive asymmetric synapses from prefrontal corticostriatal afferents Ultrastructural immunocytochemical localization of mu opioid receptors and Leu5-enkephalin in the patch compartment of the rat caudate-putamen nucleus Ultrastructural immunocytochemical localization of mu-opioid receptors in dendritic targets of dopaminergic terminals in the rat caudate-putamen nucleus Medium spiny neurons of the anterior dorsomedial striatum Research Article: New Research mediate reversal learning in a cell-type-dependent manner D1 and D2 dopamine receptor mRNA in rat brain Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice Cholinergic interneurons underlie spontaneous dopamine release in nucleus accumbens Locomotor activity: a distinctive index in morphine self-administration in rats MORs are widely expressed in the different neuronal populations and subregions of the striatum (Wang et al., 1996 (Wang et al., , 1997 Wang and Pickel, 1998; Miura et al., 2008; Cui et al., 2014) .
    keywords: day; effect; fig; genotype; item; lever; mors; neurons; opioid; oxycodone; presses; table
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        item: #51 of 156
          id: cord-033453-557obi3r
      author: Bretscher, Lorenzo
       title: COVID-19 and the Cross-Section of Equity Returns: Impact and Transmission
        date: 2020-09-24
       words: 12248
      flesch: 61
     summary: In columns 1 and 2, the baseline sample, average nonfinancial firm return is 59.2 bps lower using raw returns and 60.4 bps lower using total returns than the benchmark return calculated from the two days immediately before the event day. In particular, we regress firm level returns on 15 dummies assigned to each day around the event.
    keywords: case; county; covid-19; day; days; dummy; event day; firms; labor; level; results; returns; sample; table; total
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        item: #52 of 156
          id: cord-034448-wgvvdmxe
      author: Mahmood, Tahir
       title: Aggregation operators and VIKOR method based on complex q-rung orthopair uncertain linguistic informations and their applications in multi-attribute decision making
        date: 2020-10-30
       words: 7347
      flesch: 50
     summary: The theory of intuitionistic fuzzy uncertain aggregation operators was explored by Liu and Jin (2012) . A novel decision-making approach under complex Pythagorean fuzzy environment Maclaurin symmetric mean operators and their applications in the environment of complex q-rung orthopair fuzzy sets Complex neutrosophic generalised dice similarity measures and their application to decision making Complex T-spherical fuzzy aggregation operators with application to multi-attribute decision making Complex intuitionistic fuzzy sets New Chebyshev distance measures for Pythagorean fuzzy sets with applications to multiple criteria decision analysis using an extended ELECTRE approach A novel hybrid approach based on intuitionistic fuzzy multi criteria group-decision making for environmental pollution problem New generalised Bonferroni mean aggregation operators of complex intuitionistic fuzzy information based on Archimedean t-norm and t-conorm Robust averaging-geometric aggregation operators for complex intuitionistic fuzzy sets and their applications to MCDM process Power aggregation operators and VIKOR methods for complex q-rung orthopair fuzzy sets and their applications Fuzzy extension of the CODAS method for multi-criteria market segment evaluation Pythagorean 2-tuple linguistic VIKOR method for evaluating human factors in construction project management Generalized dice similarity measures for q-rung orthopair fuzzy sets with applications Multi-valued picture fuzzy soft sets and their applications in group decision-making problems Trapezoidal neutrosophic aggregation operators and their application to the multi-attribute decision-making process Bipolar fuzzy Dombi prioritized aggregation operators in multiple attribute decision making An MADM approach to covering-based variable precision fuzzy rough sets: an application to medical diagnosis Solving cloud vendor selection problem using intuitionistic fuzzy decision framework EDAS method for multiple attribute group decision making under q-rung orthopair fuzzy environment Consensus reaching process for fuzzy behavioral TOPSIS method with probabilistic linguistic q-rung orthopair fuzzy set based on correlation measure Intuitionistic uncertain linguistic partitioned Bonferroni means and their application to multiple attribute decision-making Multiple attribute decision making based on q-Rung Orthopair Fuzzy generalized Maclaurinsymmetic mean operators Intuitionistic uncertain linguistic weighted Bonferroni OWA operator and its application to multiple attribute decision making Pythagorean uncertain linguistic partitioned Bonferroni mean operators and their application in multi-attribute decision making A method to multi-attribute group decision-making problem with complex q-rung orthopair linguistic information based on Heronian mean operators Some q-rung orthopair uncertain linguistic aggregation operators and their application to multiple attribute group decision making Complex q-rung orthopair fuzzy aggregation operators and their applications in multi-attribute group decision making Cloud model-based PROMETHEE method under 2D uncertain linguistic environment Pythagorean uncertain linguistic aggregation operators for multiple attribute decision making An approach toward decision-making and medical diagnosis problems using the concept of spherical fuzzy sets Representing complex intuitionistic fuzzy set by quaternion numbers and applications to decision making Multiple criteria decision making based on weighted Archimedean power partitioned Bonferroni aggregation operators of generalised orthopair membership grades Multi-attribute multi-perception decision-making based on generalized T-spherical fuzzy weighted aggregation operators on neutrosophic sets Complex fuzzy sets Pythagorean m-polar fuzzy soft sets with TOPSIS method for MCGDM A unified method for Pythagorean fuzzy multicriteria group decision-making using entropy measure, linear programming and extended technique for ordering preference by similarity to ideal solution A novel interval-valued intuitionistic trapezoidal fuzzy combinative distance-based assessment (CODAS) method Z-VIKOR method based on a new comprehensive weighted distance measure of Z-number and its application Chiclana F, Liu P (2020)
    keywords: complex; decision; information; operators; table
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        item: #53 of 156
          id: cord-048360-n9sih438
      author: Villard, Viviane
       title: Rapid Identification of Malaria Vaccine Candidates Based on α-Helical Coiled Coil Protein Motif
        date: 2007-07-25
       words: 4797
      flesch: 41
     summary: Found at: doi:10.1371/journal.pone.0000645.s005 (0.05 MB DOC) Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing Reverse vaccinology and genomics Plasmodium falciparum liver stage antigen-1 is well conserved and contains potent B and T cell determinants Protection against Plasmodium falciparum malaria in chimpanzees by immunization with the conserved pre-erythrocytic liver-stage antigen 3 Phase I malaria vaccine trial with a long synthetic peptide derived from the merozoite surface protein 3 antigen Plasmodium falciparum merozoite surface protein 6 displays multiple targets for naturally occurring antibodies that mediate monocyte-dependent parasite killing Template-based coiled-coil antigens elicit neutralizing antibodies to the SARS-coronavirus Phase 1 randomized double-blind safety and immunogenicity trial of Plasmodium falciparum malaria merozoite surface protein FMP1 vaccine De novo design of alpha-helical proteins: basic research to medical applications Genome sequence of the human malaria parasite Plasmodium falciparum A flexible motif search technique based on generalized profiles Transcriptomics and proteomics: tools for the identification of novel drug targets and vaccine candidates for tuberculosis A proteomic view of the Plasmodium falciparum life cycle The Transcriptome of the Intraerythrocytic Developmental Cycle of Plasmodium falciparum Crossreactive antigens between life cycle stages of plasmodium falciparum Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes Mapping of conformational B cell epitopes within alpha-helical coiled coil proteins A de novo designed template for generating conformation-specific antibodies that recognize alpha-helices in proteins Targeting malaria virulence and remodeling proteins to the host erythrocyte A host-targeting signal in virulence proteins reveals a secretome in malarial infection Proteomic analysis identifies novel proteins of the Maurer's clefts, a secretory compartment delivering Plasmodium falciparum proteins to the surface of its host cell Multi-character population study of the vir subtelomeric multigene superfamily of Plasmodium vivax, a major human malaria parasite A Maurer's cleft-associated protein is essential for expression of the major malaria virulence antigen on the surface of infected red blood cells A novel antibody-dependent cellular cytotoxicity mechanism involved in defense against malaria requires costimulation of monocytes FcgammaRII and FcgammaRIII Predicting coiled coils from protein sequences Improved prediction of signal peptides: SignalP 3.0 TMbase-A database of membrane spanning proteins segments Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes Prediction of potential GPImodification sites in proprotein sequences pTARGET Figure S1 CD spectra of the peptides 45 (S1A) and 12 (S1B) Found at: doi:10.1371/journal.pone.0000645.s001 (12.32 MB TIF) Figure S2 ELISA inhibition assay using anti-human peptide specific antibodies.
    keywords: antibodies; assays; blood; coil; falciparum; human; malaria; parasite; peptides; proteins; sera; specific; table; vaccine
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        item: #54 of 156
          id: cord-102319-2b404su7
      author: Kang, J.
       title: Increased brain volume from cereal, decreased brain volume from coffee -- shared genetic determinants and impacts on cognitive function, body mass index (BMI) and other metabolic measures: cohort study of UK Biobank participants
        date: 2020-10-14
       words: 6552
      flesch: 39
     summary: Furthermore, we observed a significant negative genetic correlation between intake of cereal and coffee (rg=-0.233, se=0.052, z-score=-4.49, P=7.1E-06), i.e., the alleles associated with higher cereal intake were likely to be in association with reduced coffee intake, which is in line with the above GWAS findings, where the three shared lead SNPs, i.e. rs2504706, rs4410790 and 35 rs2472297, were found in associations with both cereal and coffee intake, again in opposite directions (Table S9) . https://doi.org/10.1101/2020.10.11.20210781 doi: medRxiv preprint the SNP with higher cereal intake or lower coffee intake (nor did the alternative mediation models), which was mainly due to nonconcordant correlations, e.g., a positive correlation was observed between ease in rising and higher cereal intake while a negative one was expected (Fig.3 Table S9 , S11 & S12).
    keywords: association; brain; cereal; cereal intake; coffee; coffee intake; data; gmv; intake; license; medrxiv; preprint; table
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        item: #55 of 156
          id: cord-103733-blam1f4c
      author: Levade, Inès
       title: Predicting Vibrio cholerae infection and disease severity using metagenomics in a prospective cohort study
        date: 2020-06-24
       words: 2669
      flesch: 27
     summary: key: cord-103733-blam1f4c authors: Levade, Inès; Saber, Morteza M.; Midani, Firas; Chowdhury, Fahima; Khan, Ashraful I.; Begum, Yasmin A.; Ryan, Edward T.; David, Lawrence A.; Calderwood, Stephen B.; Harris, Jason B.; LaRocque, Regina C.; Qadri, Firdausi; Shapiro, B. Jesse; Weil, Ana A. title: Predicting Vibrio cholerae infection and disease severity using metagenomics in a prospective cohort study date: 2020-06-24 journal: bioRxiv DOI: 10.1101/2020.02.25.960930 sha: doc_id: 103733 cord_uid: blam1f4c Background Susceptibility to Vibrio cholerae infection is impacted by blood group, age, and pre-existing immunity, but these factors only partially explain who becomes infected. Updated Global Burden of Cholera in Endemic 420 Countries Cholera epidemic in Yemen, 2016-18: an 422 analysis of surveillance data Defining endemic cholera at three levels of 424 spatiotemporal resolution within Bangladesh Clinical Outcomes in Household Contacts of 426 Patients with Cholera in Bangladesh Cholera transmission: the 428 host, pathogen and bacteriophage dynamic Susceptibility to Vibrio cholerae Infection 430 in a Cohort of Household Contacts of Patients with Cholera in Bangladesh Roles of the intestinal microbiota in pathogen protection Members of the human gut microbiota 435 involved in recovery from Vibrio cholerae infection Bile Salts 437 Modulate the Mucin-Activated Type VI Secretion System of Pandemic Vibrio cholerae A single gene of a commensal microbe affects host 440 susceptibility to enteric infection Probiotic strains detect and suppress 442 cholera in mice Anti-biofilm Properties of the Fecal Probiotic 444 Lactobacilli Against Vibrio spp Commensal-derived metabolites govern Vibrio cholerae 446 pathogenesis in host intestine Gut Microbial Succession Follows Acute Secretory 448 Diarrhea in Humans Human Gut Microbiota Predicts Susceptibility 450 to Vibrio cholerae Infection MetaPhlAn2 for enhanced metagenomic 452 taxonomic profiling Species-level functional profiling of 454 metagenomes and metatranscriptomes Machine Learning Meta-analysis of 456 Large Metagenomic Datasets: Tools and Biological Insights Fillat MF.
    keywords: cholerae; cohort; disease; gut; infection; species; table
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        item: #56 of 156
          id: cord-131094-1zz8rd3h
      author: Parisi, L.
       title: QReLU and m-QReLU: Two novel quantum activation functions to aid medical diagnostics
        date: 2020-10-15
       words: 7577
      flesch: 36
     summary: Furthermore, it is worth noting the proposed quantum AFs led to improved classification outcomes as compared to recent advances in ReLU AFs, such as CReLU and VLReLU: • QReLU led to ACC, precision, sensitivity/recall, and F1-score all higher by 1% those obtained via CReLU when evaluating the CNN's classification performance on the MNIST data (Table 2 ). key: cord-131094-1zz8rd3h authors: Parisi, L.; Neagu, D.; Ma, R.; Campean, F. title: QReLU and m-QReLU: Two novel quantum activation functions to aid medical diagnostics date: 2020-10-15 journal: nan DOI: nan sha: doc_id: 131094 cord_uid: 1zz8rd3h The ReLU activation function (AF) has been extensively applied in deep neural networks, in particular Convolutional Neural Networks (CNN), for image classification despite its unresolved dying ReLU problem, which poses challenges to reliable applications.
    keywords: afs; benchmark; classification; cnn; dataset; qrelu; quantum; spiral; table
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        item: #57 of 156
          id: cord-253827-5vodag6c
      author: Karaivanov, A.
       title: Face Masks, Public Policies and Slowing the Spread of COVID-19: Evidence from Canada
        date: 2020-09-25
       words: 13134
      flesch: 59
     summary: Our preferred specification with cubic time trend, column (4) of Table 3 , shows that mask mandates are associated with 31.5 percentage point increase in self-reported mask usage (p < 0.001), from a base of self-reported mask usage without mask mandate of 29.8%. Moreover, this result mitigates possible concerns that the estimated mask mandate effect on case growth may be caused by factors other than mask policy.
    keywords: cases; data; estimates; growth; level; mandates; mask; mask mandates; medrxiv; ontario; policy; preprint; province; table; time
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        item: #58 of 156
          id: cord-254193-hsu0yo5c
      author: Rosa, Gonçalo M.
       title: Unveiling patterns of viral pathogen infection in free-ranging carnivores of northern Portugal using a complementary methodological approach
        date: 2020-02-07
       words: 4737
      flesch: 43
     summary: key: cord-254193-hsu0yo5c authors: Rosa, Gonçalo M.; Santos, Nuno; Grøndahl-Rosado, Ricardo; Fonseca, Francisco Petrucci; Tavares, Luis; Neto, Isabel; Cartaxeiro, Clara; Duarte, Ana title: Unveiling patterns of viral pathogen infection in free-ranging carnivores of northern Portugal using a complementary methodological approach date: 2020-02-07 journal: Comp Immunol Microbiol Infect Dis DOI: 10.1016/j.cimid.2020.101432 sha: doc_id: 254193 cord_uid: hsu0yo5c Pathogen surveillance in free-ranging carnivores presents challenges due to their low densitie and secretive nature. [29] ), their impact in wild carnivore populations is still largely unknown, particularly among the northern Portuguese populations.
    keywords: canine; carnivores; cdv; cpv; detection; infection; populations; prevalence; samples; table; virus
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        item: #59 of 156
          id: cord-254667-yafcy8ul
      author: Sisto, Antonella
       title: The psychological impact of COVID-19 pandemic on patients included in a bariatric surgery program
        date: 2020-08-28
       words: 4658
      flesch: 34
     summary: Univariate and multivariate binary logistic regression analysis of COVID-19 related psychological markers of depression, anxiety and stress on post-bariatric subjects are summarized in Table 4 . Logistic regression analysis on post-bariatric patients showed a relationship between snacking, hunger, eating impulsivity, and anxiety, stress, and/or depression symptoms.
    keywords: anxiety; covid-19; depression; eating; patients; stress; surgery; table
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        item: #60 of 156
          id: cord-255087-fwsicgv1
      author: Thomas, V. J.
       title: Endowing university spin-offs pre-formation: Entrepreneurial capabilities for scientist-entrepreneurs
        date: 2020-05-03
       words: 14834
      flesch: 32
     summary: Additional or alternative educational programs, focused on building pre-formation entrepreneurial capabilities in university scientists, could unlock substantial additional value from university inventions. We propose that such entrepreneurial capabilities can also be taught more broadly to university scientists.
    keywords: capabilities; formation; lab; market; matching; offs; patent; pre; science; scientist; spin; sse; star; table; technology; university spin; venture
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        item: #61 of 156
          id: cord-255140-3dwqqgv1
      author: Christian, Michael D.
       title: Biowarfare and Bioterrorism
        date: 2013-07-04
       words: 9453
      flesch: 38
     summary: The US Centers for Disease Control and Prevention (CDC) has identified and categorized a list of potential bioterrorism agents ( Table 1 ). 7, 19, 24, 35 The CDC list of potential bioterrorism agents (see Table 1 ) includes several toxins.
    keywords: agents; anthrax; biological; bioterrorism; care; cases; diagnosis; disease; event; fever; health; infection; patients; plague; potential; smallpox; table; toxin
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        item: #62 of 156
          id: cord-256065-zz2907h0
      author: Barral-Arca, Ruth
       title: A Meta-Analysis of Multiple Whole Blood Gene Expression Data Unveils a Diagnostic Host-Response Transcript Signature for Respiratory Syncytial Virus
        date: 2020-03-06
       words: 5659
      flesch: 35
     summary: PI19/01090/Cofinanciado FEDER) given to F.M.-T. Biomarkers of respiratory syncytial virus (RSV) infection: Specific neutrophil and cytokine levels provide increased accuracy in predicting disease severity Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: A systematic review and modelling study Whole blood gene expression in infants with respiratory syncytial virus bronchiolitis Risk of primary infection and reinfection with respiratory syncytial virus Review of epidemiology and clinical risk factors for severe respiratory syncytial virus (RSV) infection Risk factors in children hospitalized with RSV bronchiolitis versus non-RSV bronchiolitis The burden of respiratory syncytial virus infection in young children Whole Exome Sequencing reveals new candidate genes in host genomic susceptibility to Respiratory Syncytial Virus Disease Increased concordance of severe respiratory syncytial virus infection in identical twins Disease severity in respiratory syncytial virus infection: Role of host genetic variation Respiratory Syncytial Virus Bronchiolitis in Children up to 5 Years of Age in Spain: Epidemiology and Comorbidities: An Observational Study Diagnosis of childhood tuberculosis and host RNA expression in Africa Diagnostic Test Accuracy of a 2-Transcript Host RNA Signature for Discriminating Bacterial vs Viral Infection in Febrile Children Whole blood gene expression profiles to assess pathogenesis and disease severity in infants with respiratory syncytial virus infection A 2-transcript host cell signature distinguishes viral from bacterial diarrhea and it is influenced by the severity of symptoms A qPCR expression assay of IFI44L gene differentiates viral from bacterial infections in febrile children Diagnosis of Kawasaki disease using a minimal whole-blood gene expression signature Gene expression and regulation in systemic lupus erythematosus How to read a systematic review and meta-analysis and apply the results to patient care: Users' guides to the medical literature Power failure: Why small sample size undermines the reliability of neuroscience Genome-wide expression for diagnosis of pulmonary tuberculosis: A multicohort analysis Host-response-based gene signatures for tuberculosis diagnosis: A systematic comparison of 16 signatures A 20-Gene Set Predictive of Progression to Severe Dengue A community approach to mortality prediction in sepsis via gene expression analysis 2 -5 -Oligoadenylate Synthetase-Like Functional enrichment analysis showed several pathways significantly altered, including immunologic response mediated by RSV infection, pattern recognition receptors, cell cycle, and olfactory signaling.
    keywords: analysis; expression; genes; host; infection; rsv; table; value; virus
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        item: #63 of 156
          id: cord-257336-rpx71ww5
      author: Doukas, Sotirios G.
       title: E-cigarette or vaping induced lung injury: A case series and literature review
        date: 2020-10-03
       words: 4719
      flesch: 45
     summary: Future studies focusing on the comparison of clinical, laboratory and imaging findings of EVALI patients with patients presenting with similar respiratory conditions, with similar clinical manifestations, such as COVID-19, will contribute significantly in the development of standardized approach for EVALI diagnosis and treatment. EVALI patients with radiological findings of lung injury, although mainly present respiratory symptoms, may very often appear with constitutional and gastrointestinal symptoms.
    keywords: cases; cigarette; disease; evali; lung; patients; table; use; vaping
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        item: #64 of 156
          id: cord-257958-yehnlabq
      author: Barh, Debmalya
       title: Multi-omics-based identification of SARS-CoV-2 infection biology and candidate drugs against COVID-19
        date: 2020-10-10
       words: 5439
      flesch: 35
     summary: [14] and DrugMatrix (a Comprehensive Toxicogenomic Database) for gene set analysis based candidate drug enrichment. gene set analysis toolkit with revamped UIs and APIs DrugBank: a comprehensive resource for in silico drug discovery and exploration NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis InnateDB: systems biology of innate immunity and beyond--recent updates and continuing curation KEGG: new perspectives on genomes, pathways, diseases and drugs PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools The AI-Discovered Aetiology of COVID-19 and Rationale of the Irinotecan+Etoposide Combination Therapy for Critically Ill COVID-19 Patients Vulnerabilities of the SARS-CoV-2 virus to proteotoxicityopportunity for repurposed chemotherapy of COVID-19 infection, bioRxiv SARS-CoV-2 (COVID-19) and Chronic Myeloid Leukemia (CML): a Case Report and Review of ABL Kinase Involvement in Viral Infection Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19, bioRxiv Silico Discovery of Candidate Drugs against Covid-19, Viruses Prediction of repurposed drugs for treating lung injury in COVID-19 Artificial intelligence approach fighting COVID-19 with repurposing drugs COVID-19: Drug Targets and Potential Treatments The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2, bioRxiv Broad anti-coronaviral activity of FDA approved drugs against SARS-CoV-2 in vitro and SARS-CoV in vivo, bioRxiv Understanding SARS CoV 2 endocytosis for COVID 19 drug repurposing Indomethacin has a potent antiviral activity against SARS CoV-2 in vitro and canine coronavirus in vivo, bioRxiv Indomethacin and resveratrol as potential treatment adjuncts for SARS CoV 2/COVID 19 Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning Repurposing drugs for COVID-19 based on transcriptional response of host cells to SARS-CoV-2, arXiv Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: an in silico approach Apremilast as a potential treatment option for COVID 19: No symptoms of infection in a psoriatic patient Combination of thrombolytic and immunosuppressive therapy for coronavirus disease 2019:
    keywords: analysis; candidate; cov-2; covid-19; drugs; gene; infection; omics; pathways; potential; sars; set; table
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        item: #65 of 156
          id: cord-257969-2tax8ajw
      author: Bhopal, Raj S.
       title: COVID-19 zugzwang: potential public health moves towards population (herd) immunity
        date: 2020-07-15
       words: 4251
      flesch: 48
     summary: To control an infection with an R of about 1 and even somewhat higher we need about 50% of the population to have immunity (unlike measles where over 90% is needed).(5, 6) Currently, the prevalence of COVID-19 infection is variably estimated from 1-20% according to locality and work settings. Until there is a vaccine, population immunity is going to occur only from infection.
    keywords: column; covid-19; health; immunity; infection; people; population; public; table
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        item: #66 of 156
          id: cord-260014-q5sug7uu
      author: Szűcs, Zsolt
       title: Reprogramming of the Antibacterial Drug Vancomycin Results in Potent Antiviral Agents Devoid of Antibacterial Activity
        date: 2020-06-29
       words: 5215
      flesch: 45
     summary: Viruses Emerging antiviral strategies to interfere with influenza virus entry Antiviral therapies on the horizon for influenza Advancements in host-based interventions for influenza treatment Fighting viruses with antibiotics: An overlooked path Drug repurposing approaches for the treatment of influenza viral infection: Reviving old drugs to fight against a long-lived enemy Teicoplanin inhibits Ebola pseudovirus infection in cell culture Glycopeptide antibiotics potently inhibit cathepsin L in the late endosome/lysosome and block the entry of Ebola virus, Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus (SARS-CoV) Antiretroviral activity of semisynthetic derivatives of glycopeptide antibiotics Polycyclic peptide and glycopeptide antibiotics and their derivatives as inhibitors of HIV entry Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics Inhibition of hepatitis C virus replication by semi-synthetic derivatives of glycopeptide antibiotics An analogue of the antibiotic teicoplanin prevents Flavivirus entry in vitro Anti-influenza virus activity and structure-activity relationship of aglycoristocetin derivatives with cyclobutenedione carrying hydrophobic chains Intracytoplasmic trapping of influenza virus by a lipophilic derivative of aglycoristocetin Diazo transfer-click reaction route to new, lipophilic teicoplanin and ristocetin aglycon derivatives with high antibacterial and anti-influenza virus activity: An aggregation and receptor binding study Synthesis of fluorescent ristocetin aglycone derivatives with remarkable antibacterial and antiviral activities Synthesis of isoindole and benzoisoindole derivatives of teicoplanin pseudoaglycone with remarkable antibacterial and antiviral activities A few atoms make the difference: Synthetic, CD, NMR and computational studies on antiviral and antibacterial activities of glycopeptide antibiotic aglycone derivatives Semisynthetic teicoplanin derivatives as new influenza virus binding inhibitors: Synthesis and antiviral studies Synthesis and biological evaluation of lipophilic teicoplanin pseudoaglycone derivatives containing a substituted triazole function Structure-activity relationship studies of lipophilic teicoplanin pseudoaglycon derivatives as new anti-influenza virus agents Structure-activity relationship studies of a series of antiviral and antibacterial aglycon derivatives of the glycopeptide antibiotics vancomycin, eremomycin, and dechloroeremomycin Structural modifications of the active site in teicoplanin and related glycopeptides. Hence, we established, by virus yield assays, that compound 6 suppresses the replication of influenza virus and coronavirus, and for the other viruses, activity was indicated by the protection against viral CPE.
    keywords: activity; antiviral; compound; derivative; influenza; mmol; reaction; table; teicoplanin; virus
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        item: #67 of 156
          id: cord-260728-4w23kwzu
      author: Timmermans, Ans
       title: Human Sentinel Surveillance of Influenza and Other Respiratory Viral Pathogens in Border Areas of Western Cambodia
        date: 2016-03-30
       words: 7426
      flesch: 44
     summary: Previous studies have attributed the etiology of acute viral respiratory infections in Cambodia to rhinovirus, respiratory syncytial virus (RSV), parainfluenza virus (PIV), influenza virus A and B, human metapneumovirus (HMPV), bocavirus, adenovirus, enterovirus, and coronavirus Influenza virus efficiently escapes from host antibodies through an accumulation of mutations/single amino acid changes (antigenic drift) at the antigenic sites (epitopes) in surface glycoproteins of the hemagglutinin (HA) gene, and to a lesser extent, neuraminidase (NA) genes [8] .
    keywords: acid; amino; antigenic; cambodia; changes; gene; influenza; isolates; pcr; samples; sequences; sites; specimens; study; table; virus
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        item: #68 of 156
          id: cord-262760-mf1pn587
      author: Weber, Stefanie
       title: Signal hotspot mutations in SARS-CoV-2 genomes evolve as the virus spreads and actively replicates in different parts of the world
        date: 2020-09-24
       words: 4672
      flesch: 50
     summary: Hence, the consequences of an increase in the number of viral mutations on its pathogenicity will be very difficult to predict. Additionally, in sequence positions 28854 and 28863 a few C → T point mutations were apparent.
    keywords: china; cov-2; mutations; positions; rna; sars; sequence; table
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        item: #69 of 156
          id: cord-264814-v4wnmg03
      author: Flanagan, Katie L.
       title: Progress and Pitfalls in the Quest for Effective SARS-CoV-2 (COVID-19) Vaccines
        date: 2020-10-02
       words: 15157
      flesch: 34
     summary: Med Hypotheses Antibodies against trimeric S glycoprotein protect hamsters against SARS-CoV challenge despite their capacity to mediate FcgammaRII-dependent entry into B cells in vitro Early death after feline infectious peritonitis virus challenge due to recombinant vaccinia virus immunization Monoclonal antibody analysis of neutralization and antibody-dependent enhancement of feline infectious peritonitis virus Monoclonal antibodies to the spike protein of feline infectious peritonitis virus mediate antibody-dependent enhancement of infection of feline macrophages Evaluation of modified vaccinia virus ankara based recombinant SARS vaccine in ferrets Molecular mechanism for antibody-dependent enhancement of coronavirus entry Distinct systems serology features in children, elderly and COVID patients. The standardization of a range of assays to support vaccine studies, such as viral neutralization assays, to enable comparison of different vaccine candidates in different populations will be key to facilitating vaccine development, an issue which represents a current focus of the WHO (43).
    keywords: cell; challenge; coronavirus; cov-2; covid-19; development; disease; dna; human; immunity; infection; key; nabs; patients; phase; protein; response; safety; sars; studies; table; trials; vaccine; virus
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        item: #70 of 156
          id: cord-264976-6n9cdex6
      author: Corse, Tanner
       title: Clinical Outcomes of COVID-19 Patients with Pre-existing, Compromised Immune Systems: A Review of Case Reports
        date: 2020-10-18
       words: 6122
      flesch: 35
     summary: To learn more about such individuals, we conducted a search and review of published reports on the clinical characteristics and outcomes of COVID-19 patients with pre-existing, compromised immune systems. Most symptomatic COVID-19 patients recover with supportive care in hospitals; however, a small but significant percentage of COVID-19 patients are at risk of developing acute respiratory distress syndrome (ARDS) or respiratory failure [7, 8] .
    keywords: cov-2; covid-19; mortality; patients; rate; recipients; sars; table; transplant
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        item: #71 of 156
          id: cord-266036-qhlo99l7
      author: Axell-House, Dierdre B.
       title: The Estimation of Diagnostic Accuracy of Tests for COVID-19: A Scoping Review
        date: 2020-08-31
       words: 5764
      flesch: 36
     summary: A review of methods Using a combination of reference tests to assess the accuracy of a new diagnostic test Value of composite reference standards in diagnostic research Diagnostic test evaluation methodology: A systematic review of methods employed to evaluate diagnostic tests in the absence of gold standard -An update Food and Drug Administration CfDaRH. However, our scoping review also uncovered imperfect methods for estimating diagnostic test performance in the absence of a gold standard and demonstrate that the accuracy of these tests should be interpreted with caution.
    keywords: cov-2; pcr; reference; rrt; sars; standard; studies; table; test
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        item: #72 of 156
          id: cord-266255-898h9rl1
      author: None
       title: Full Issue PDF
        date: 2020-08-31
       words: 17697
      flesch: 32
     summary: EACVI recommendations on precautions, indications, prioritization, and protection for patients and healthcare personnel ASE statement on protection of patients and echocardiography service providers during the 2019 novel coronavirus outbreak Focused cardiac ultrasonography Echocardiography in the time of COVID-19 Coronary CT angiography versus standard evaluation in acute chest pain Triple rule out versus coronary CT angiography in patients with acute chest pain results from the ACIC consortium Cardiac computed tomography in troponin-positive chest pain: sometimes the answer lies in the late iodine enhancement or extracellular volume fraction map Quadruple rule out with cardiac computed tomography in COVID-19 patient with equivocal acute coronary syndrome presentation Cardiovascular magnetic resonance in nonischemic myocardial inflammation: expert recommendations Early T1 myocardial MRI mapping: value in detecting myocardial hyperemia in acute myocarditis Guidance and best practices for nuclear cardiology laboratories during the coronavirus disease 2019 (COVID-19) pandemic: an information statement from ASNC and SNMMI 2020 Management of acute myocardial infarction during the COVID-19 pandemic Virtually perfect? key: cord-266255-898h9rl1 authors: nan title: Full Issue PDF date: 2020-08-31 journal: JACC: Cardiovascular Imaging DOI: 10.1016/s1936-878x(20)30581-7 sha: doc_id: 266255 cord_uid: 898h9rl1 nan studies in patients with mitral valve disease have identified atrial fibrillation (AF) as a risk factor (6, 7) , others have found pulmonary artery systolic pressures (PASPs) to be the most powerful predictor of TR progression (4) .
    keywords: analysis; artery; burden; cad; cardiac; coronary; covid-19; disease; echocardiography; figure; flow; heart; imaging; ischemic; left; lge; myocardial; patients; risk; scar; score; stenosis; study; table; tomography; ventricular; volume
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        item: #73 of 156
          id: cord-267866-854rzbrx
      author: Dohaney, Jacqueline
       title: Benefits, barriers, and incentives for improved resilience to disruption in university teaching
        date: 2020-05-29
       words: 6950
      flesch: 35
     summary: With the dominant themes pointing 320 to a personal and professional development aspect, building resilience can be directly 321 beneficial to the individual, as well as the institution, and can be communicated this way. 322 Participants also report that building resilience could reduce the emotional impact of 323 disruptive events giving academics more control over what is happening, allowing them to 324 support their learners, colleagues, and families.
    keywords: academics; barriers; benefits; building; disruption; l&t; learning; participants; research; resilience; staff; teaching
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        item: #74 of 156
          id: cord-268645-5op2m7pu
      author: Wu, Zhiqiang
       title: Deciphering the bat virome catalog to better understand the ecological diversity of bat viruses and the bat origin of emerging infectious diseases
        date: 2015-08-11
       words: 5953
      flesch: 40
     summary: key: cord-268645-5op2m7pu authors: Wu, Zhiqiang; Yang, Li; Ren, Xianwen; He, Guimei; Zhang, Junpeng; Yang, Jian; Qian, Zhaohui; Dong, Jie; Sun, Lilian; Zhu, Yafang; Du, Jiang; Yang, Fan; Zhang, Shuyi; Jin, Qi title: Deciphering the bat virome catalog to better understand the ecological diversity of bat viruses and the bat origin of emerging infectious diseases date: 2015-08-11 journal: The ISME Journal DOI: 10.1038/ismej.2015.138 sha: doc_id: 268645 cord_uid: 5op2m7pu Studies have demonstrated that ~60%–80% of emerging infectious diseases (EIDs) in humans originated from wild life. In conclusion, the understanding of the viral community characteristics, genetics and ecological distribution of bat viruses could enable the rapid identification of novel viruses with variant genomes and could thus facilitate the tracing of EIDs in bats.
    keywords: bat; bats; covs; et al; figure; human; novel; reads; samples; sars; species; table; viruses
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        item: #75 of 156
          id: cord-269711-tw5armh8
      author: Ma, Junling
       title: The importance of contact network topology for the success of vaccination strategies
        date: 2013-05-21
       words: 7039
      flesch: 53
     summary: The last network considered is what we term a meta-random network where random networks of various sizes are connected with a small number of interlinks. Considering that a metarandom network is a random network of random networks, it is likely that the meta-random network represents a general population better than a random network.
    keywords: degree; disease; network; nodes; number; rate; strategies; transmission; vaccination
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        item: #76 of 156
          id: cord-270892-ycc3csyh
      author: Rollinger, Judith M.
       title: The human rhinovirus: human‐pathological impact, mechanisms of antirhinoviral agents, and strategies for their discovery
        date: 2010-12-13
       words: 19699
      flesch: 35
     summary: if by hand How contagious are common respiratory tract infections? Environmental contamination with rhinovirus and transfer to fingers of healthy individuals by daily life activity Aerosol transmission of rhinovirus colds Hand-to-hand transmission of rhinovirus colds Transmission of experimental rhinovirus infection by contaminated surfaces Interruption of experimental rhinovirus transmission Virucidal activity and cytotoxicity of the liposomal formulation of povidone-iodine Virucidal hand treatments for prevention of rhinovirus infection Localization of human rhinovirus replication in the upper respiratory tract by in situ hybridization Experimental rhinovirus infection in volunteers Detection of rhinovirus RNA in lower airway cells during experimentally induced infection Relationship of upper and lower airway cytokines to outcome of experimental rhinovirus infection Histopathologic examination and enumeration of polymorphonuclear leukocytes in the nasal mucosa during experimental rhinovirus colds Sites of rhinovirus recovery after point inoculation of the upper airway Incubation periods of experimental rhinovirus infection and illness Quantitative and qualitative analysis of rhinovirus infection in bronchial tissues Rhinoviruses infect the lower airways Incidence and characteristics of viral community-acquired pneumonia in adults Etiology of community-acquired pneumonia in 254 hospitalized children Improved diagnosis of the etiology of community-acquired pneumonia with real-time polymerase chain reaction Etiology of community-acquired pneumonia in hospitalized school-age children: Evidence for high prevalence of viral infections Association between interleukin-8 concentration in nasal secretions and severity of symptoms of experimental rhinovirus colds Symptom profile of common colds in schoolaged children The microbial etiology and antimicrobial therapy of adults with acute community-acquired sinusitis: A fifteen-year experience at the University of Virginia and review of other selected studies Bacterial coinfections in children with viral wheezing Amplified rhinovirus colds in atopic subjects Experimental rhinovirus 16 infection potentiates histamine release after antigen bronchoprovocation in allergic subjects Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects The effects of rhinovirus infections on allergic airway responses Rhinovirus upper respiratory infection increases airway hyperreactivity and late asthmatic reactions An experimental model of rhinovirus induced chronic obstructive pulmonary disease exacerbations: A pilot study Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production The economic burden of non-influenzarelated viral respiratory tract infection in the United States Rhinovirus chemotherapy Excessive antibiotic use for acute respiratory infections in the United States Influenza virus and rhinovirus-related otitis media: Potential for antiviral intervention The viruses and their replication Analysis of the structure of a common cold virus, human rhinovirus 14, refined at a resolution of 3.0 A The refined structure of human rhinovirus 16 at 2.15 A resolution: Implications for the viral life cycle Crystal structure of human rhinovirus serotype 1A (HRV1A) 1. Effect of shape on binding of steroids to carrier proteins Investigation on QSAR and binding mode of a new class of human rhinovirus-14 inhibitors by CoMFA and docking experiments Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus CoMFA analysis of the interactions of antipicornavirus compounds in the binding pocket of human rhinovirus-14 dihydro-2-oxazolyl)phenoxy]alkyl]-3-methylisoxazoles: Inhibitors of picornavirus uncoating Understanding human rhinovirus infections in terms of QSAR Site-directed mutagenesis suggests close functional relationship between a human rhinovirus 3C cysteine protease and cellular trypsin-like serine proteases The picornaviral 3C proteinases: Cysteine nucleophiles in serine proteinase folds Substituted benzamide inhibitors of human rhinovirus 3C protease: Structure-based design, synthesis, and biological evaluation Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors.
    keywords: activity; agents; antiviral; binding; capsid; cells; cold; compounds; discovery; drug; echinacea; effect; efficacy; fig; group; hrv; human; infection; inhibitors; protease; protein; receptor; replication; results; rhinovirus; rhinovirus infection; rna; serotypes; structure; studies; study; synthesis; table; treatment
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        item: #77 of 156
          id: cord-270940-acwkh6ed
      author: Kallio-Kokko, Hannimari
       title: Viral zoonoses in Europe
        date: 2005-06-29
       words: 14707
      flesch: 41
     summary: key: cord-270940-acwkh6ed authors: Kallio-Kokko, Hannimari; Uzcategui, Nathalie; Vapalahti, Olli; Vaheri, Antti title: Viral zoonoses in Europe date: 2005-06-29 journal: FEMS Microbiol Rev DOI: 10.1016/j.femsre.2005.04.012 sha: doc_id: 270940 cord_uid: acwkh6ed A number of new virus infections have emerged or re-emerged during the past 15 years. During the past 15 years a number of new virus infections have emerged or re-emerged.
    keywords: antibodies; avian; cases; congo; crimean; detection; disease; encephalitis; europe; fever; fever virus; fig; genome; hantavirus; human; infections; influenza; kda; new; patients; protein; rabies; rna; segment; species; table; tick; virus; viruses; years
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        item: #78 of 156
          id: cord-270970-9gtnsyts
      author: Wolf, Michael S.
       title: Awareness, Attitudes, and Actions Related to COVID-19 Among Adults With Chronic Conditions at the Onset of the U.S. Outbreak: A Cross-sectional Survey
        date: 2020-04-09
       words: 4497
      flesch: 45
     summary: Health literacy has emerged over the past 3 decades as one of the strongest psychosocial determinants of health, and it has also been shown to explain a range of health disparities by age, race/ ethnicity, and socioeconomic status (6) . We focused on the role of health literacy and other psychosocial health determinants in understanding risks for COVID-19 and the initiation of preventive behaviors. health services, are sponsored by the National Institutes of Health, and are taking place among 7 primary care sites (5 academic internal medicine clinics and 2 federally qualified health centers) across the greater Chicago area ( Table 1) .
    keywords: adults; coronavirus; covid-19; health; literacy; outbreak; participants; study; survey
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        item: #79 of 156
          id: cord-271032-imc6woht
      author: Schulte-Schrepping, Jonas
       title: Severe COVID-19 is marked by a dysregulated myeloid cell compartment
        date: 2020-08-05
       words: 9745
      flesch: 42
     summary: Interestingly, immature cell clusters in severe COVID-19 showed signs of recent activation 390 like upregulation of CD64 (Mortaz et al., 2018) , RANK and RANKL (Riegel et al., 2012) , as 391 well as reduced CD62L expression (Mortaz et al., 2018) . Plotting cell cluster-specific surface marker expression onto 384 the UMAPs (Fig. 6C ) as well as statistical analyses of cell cluster distribution and surface 385 marker expression among different patient groups supported these observations (Fig. 386 6D+E) .
    keywords: analysis; cell; cluster; cohort; covid-19; data; disease; expression; fig; genes; hla; marker; monocytes; neutrophils; patients; pbmc; samples; scrna; seq; table
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        item: #80 of 156
          id: cord-271599-1yu1yl12
      author: Bailey, Stacy Cooper
       title: Changes in COVID-19 Knowledge, Beliefs, Behaviors, and Preparedness Among High-Risk Adults from the Onset to the Acceleration Phase of the US Outbreak
        date: 2020-09-01
       words: 4056
      flesch: 49
     summary: In multivariable analyses, black adults and those with lower health literacy were more likely to report less perceived susceptibility to COVID-19 (black adults: relative risk (RR) 1.62, 95% confidence interval (CI) 1.07–2.44, p = 0.02; marginal health literacy: RR 1.96, 95% CI 1.26–3.07, p < 0.01). Individuals with low health literacy remained more likely to feel unprepared for the outbreak (RR 1.80, 95% CI 1.11–2.92, p = 0.02) and to express confidence in the federal government response (RR 2.11, 95% CI 1.49–3.00, p < 0.001)
    keywords: adults; covid-19; health; literacy; outbreak; participants; wave
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        item: #81 of 156
          id: cord-273906-s7l0yxc0
      author: Ranga, Vipin
       title: Immunogenic SARS-CoV-2 Epitopes: In Silico Study Towards Better Understanding of COVID-19 Disease—Paving the Way for Vaccine Development
        date: 2020-07-23
       words: 7109
      flesch: 41
     summary: Furthermore, the latest experimental reports suggest that the S glycoprotein of SARS-CoV-2 is both O-and N-glycosylated, especially on the RDB domain, which could mask immunogenic epitopes and may play an important role in SARS-CoV-2 immune evasion [61] MHC-I allotypes are known to bind epitopes with lengths of 8 to 11 amino acids.
    keywords: a*02:01; allotypes; binding; cell; class; complex; cov-2; epitopes; hla; iedb; mhc; protein; sars; table
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        item: #82 of 156
          id: cord-273992-xddikzxs
      author: Wiseman, A.
       title: Avoidance of oxidative‐stress perturbation in yeast bioprocesses by proteomic and genomic biostrategies?
        date: 2004-11-10
       words: 2661
      flesch: 23
     summary: Each of such redox couples displays an experimentally determined redox potential (reduction oxidation potential) of a particular voltage under standard (defined) conditions of temperature and pressure (usually 25°C, pH 7AE0, 1 atm). A web of interactions is evident amongst biomolecules in micro-organisms, disturbance of such biomolecular webs by toxic substances is often the basis of the toxic manifestations seen as loss of homeostasis in pure cultures of micro-organisms.
    keywords: antioxidant; bioprocess; enzymes; micro; organisms; proteins; ros; species; yeast
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        item: #83 of 156
          id: cord-275258-azpg5yrh
      author: Mead, Dylan J.T.
       title: Visualization of protein sequence space with force-directed graphs, and their application to the choice of target-template pairs for homology modelling
        date: 2019-07-26
       words: 6335
      flesch: 48
     summary: As the taxonomical distance increases, production of high quality homology models becomes more difficult. Human-infective virus Importance to human health NCBI RefSeq annotated genome Easy retrieval of high quality RdRP sequence RdRP located at the 3 0 end of polyprotein or on its own segment Eliminates unconventional RdRPs
    keywords: genus; homology; modelling; models; quality; rdrp; sequence; structure; table; target; template
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        item: #84 of 156
          id: cord-275720-kf9m4zho
      author: Cho, Won Kyong
       title: Genome-wide expression profiling shows transcriptional reprogramming in Fusarium graminearum by Fusarium graminearum virus 1-DK21 infection
        date: 2012-05-06
       words: 7177
      flesch: 42
     summary: To identify differentially expressed genes, we first performed hierarchical clustering, which identified gene sets of significantly differentially expressed genes at Figure 2 Differentially expressed F. graminearum genes during FgV1-DK21 infection identified by microarray. Differentially expressed F. graminearum genes at 36 h.Additional file 2: Table S2 .
    keywords: dk21; expression; fgv1; figure; fungal; fusarium; genes; graminearum; host; infection; microarray; time; virus
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        item: #85 of 156
          id: cord-279528-41atidai
      author: Abo-Elkhier, Mervat M.
       title: Measuring Similarity among Protein Sequences Using a New Descriptor
        date: 2019-11-22
       words: 3048
      flesch: 52
     summary: The graphical representation of protein sequence is a simple way to visualize protein sequences. Basic local alignment search tool Gapped BLAST and PSI-BLAST: a new generation of protein database search programs CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice Graphical representation of proteins Similarity/dissimilarity calculation methods of DNA sequences: a survey Highly compact 2D graphical representation of DNA sequences, SAR and QSAR Unique graphical representation of protein sequences based on nucleotide triplet codons Novel 2-D graphical representation of proteins Representation of protein sequences on latitude-like circles and longitude-like semi-circles On a geometry-based approach to protein sequence alignment DNA sequence comparison by a novel probabilistic method 2-D Graphical representation of proteins based on physico-chemical properties of amino acids A 2D graphical representation of protein sequence and its numerical characterization 3-D maps and coupling numbers for protein sequences 3D graphical representation of protein sequences and their statistical characterization DNA sequence representation without degeneracy Protein map: an alignment-free sequence comparison method based on various properties of amino acids On novel representation of proteins based on amino acid adjacency matrix Protein alignment: exact versus approximate.
    keywords: amino; protein; representation; sequences; similarity; table
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        item: #86 of 156
          id: cord-279551-py2awuav
      author: Willi, Barbara
       title: Clinical and molecular investigation of a canine distemper outbreak and vector-borne infections in a group of rescue dogs imported from Hungary to Switzerland
        date: 2015-07-16
       words: 6271
      flesch: 49
     summary: Canine distemper spillover in domestic dogs from urban wildlife Canine distemper in terrestrial carnivores: a review Canine distemper virus-a morbillivirus in search of new hosts? Serological and demographic evidence for domestic dogs as a source of canine distemper virus infection for Serengeti wildlife Pathogenesis of canine distemper Inactivation of laboratory animal RNA-viruses by physicochemical treatment Lymphocyte-mediated immune cytotoxicity in dogs infected with virulent canine distemper virus Canine distemper virus Canine distemper virus uses both the anterograde and the hematogenous pathway for neuroinvasion Acute canine distemper encephalitis is associated with rapid neuronal loss and local immune activation Infectious Diseases of the Dog and Cat Neurological manifestations of canine distemper virus infection Vaccination of dogs with modified distemper virus Distemper epidemic in Switzerland: epidemiology and anamnesis of vaccination Emergence of canine distemper virus strains with modified molecular signature and enhanced neuronal tropism leading to high mortality in wild carnivores Real-time reverse transcription polymerase chain reaction method for detection of Canine distemper virus modified live vaccine shedding for differentiation from infection with wild-type strains Whole genome sequence analysis of the arctic-lineage strain responsible for distemper in Italian wolves and dogs through a fast and robust next generation sequencing protocol Vaccine use and disease prevalence in dogs and cats GST) und Schweizerische Vereinigung für Kleintiermedizin (SVK) Duration of immunity induced by companion animal vaccines Age and long-term protective immunity in dogs and cats Detection of canine distemper virus in dogs by real-time RT-PCR Comparison of the immunofluorescence assay with RT-PCR and nested PCR in the diagnosis of canine distemper Comparison of tissue and fluid samples for the early detection of canine distemper virus in experimentally infected dogs Occurrence of different Canine distemper virus lineages in Italian dogs An outbreak of dog distemper among seals (2) Baikal seal virus Comparison of two morbilliviruses isolated from seals during outbreaks of distemper in north west Europe and Siberia Genetic diversity of Hungarian canine distemper virus strains Heterogeneity within the hemagglutinin genes of canine distemper virus (CDV) strains detected in Italy Arctic lineage-canine distemper virus as a cause of death in Apennine wolves (Canis lupus) in Italy Canine and feline dirofilariasis: life cycle, pathophysiology, and diagnosis Guidelines for diagnosis and clinical classification of leishmaniasis in dogs Pediatric clinical pathology Feline leukemia virus and other pathogens as important threats to the survival of the critically endangered Iberian lynx (Lynx pardinus) High viral loads despite absence of clinical and pathological findings in cats experimentally infected with feline coronavirus (FCoV) type I and in naturally FCoV-infected cats Quantitative real-time PCR for the measurement of 11beta-HSD1 and 11beta-HSD2 mRNA levels in tissues of healthy dogs Emergence of canine distemper in Bavarian wildlife associated with a specific amino acid exchange in the haemagglutinin protein Geneious Basic: an integrated and extendable desktop software platform for the organization and analysis of sequence data Prospects for inferring very large phylogenies by using the neighbor-joining method A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences Molecular Evolutionary Genetics Analysis version 6.0 Cross-species recombination in the haemagglutinin gene of canine distemper virus Evaluation of enzyme-linked immunosorbent assays, an immunofluorescent-antibody test, and two rapid tests (immunochromatographic-dipstick and gel tests) for serological diagnosis of symptomatic and asymptomatic Leishmania infections in dogs Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Dogs that develop an adequate immune response can clear the virus from most tissues, whereas in dogs that show an intermediate immune response, CDV infects the epithelial tissues and induces clinical signs.
    keywords: animal; canine; cdv; distemper; dogs; infection; months; pcr; switzerland; table; time; vaccination; virus
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        item: #87 of 156
          id: cord-280624-7v8xuicg
      author: Ba Abduallah, Mohamed M.
       title: Comparative analysis of the genome structure and organization of the Middle East respiratory syndrome coronavirus (MERS‐CoV) 2012 to 2019 revealing evidence for virus strain barcoding, zoonotic transmission, and selection pressure
        date: 2020-08-17
       words: 2585
      flesch: 57
     summary: The phylogenetic tree of the 57 MERS-CoV of S gene sequences is presented in Figure 2C . Comparative genome sequence analysis of the MERS-CoV of both dromedary camels and human origins revealed significant evidence for potential barcoding of the African clades based on the S gene sequences.
    keywords: cov; gene; genome; mers; sequences; table
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        item: #88 of 156
          id: cord-281464-15ld7knm
      author: Belova, Natalya V.
       title: Molecular structure and electron distribution of 4-nitropyridine N-oxide: Experimental and theoretical study of substituent effects
        date: 2020-05-17
       words: 4223
      flesch: 49
     summary: Indeed, the electron-withdrawing -NO 2 group is a part of π-conjugated system of the molecule, and as result electron density is shifted from O1 atom and pyridine ring towards the substituent. We would like to point out the magnitude of electron density into pyridine ring is changed quantitatively but topologically electron density distribution does not changed dramatically between non-and substituted pyridine-N-oxides (see Figure 7 and Table 6 ).
    keywords: bond; density; electron; group; oxide; pyo; pyridine; ring; structure; table
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        item: #89 of 156
          id: cord-281668-960trqex
      author: Dana, Dibyendu
       title: A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L
        date: 2020-02-06
       words: 22099
      flesch: 36
     summary: 293T cells Rational design of aziridine-containing cysteine protease inhibitors with improved potency: Studies on inhibition mechanism Vinyl sulfones as mechanism-based cysteine protease inhibitors Peptidyl vinyl sulphones: A new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L Relative rates of Michael reactions of 2 '-(phenethyl)thiol with vinyl sulfones, vinyl sulfonate esters, and vinyl sulfonamides relevant to vinyl sulfonyl cysteine protease inhibitors Vinyl sulfonate esters and vinyl sulfonamides: Potent, irreversible inhibitors of cysteine proteases The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L Peptidyl aldehyde derivatives as potent and selective inhibitors of cathepsin L Suppressive effect of N-(benzyloxycarbonyl)-L-phenylalanyl-L-tyrosinal on bone resorption in vitro and in vivo Azepanone-based inhibitors of human and rat cathepsin K Azepanone-based inhibitors of human cathepsin S: Optimization of selectivity via the P2 substituent The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K Clinical and translational pharmacology of the cathepsin K inhibitor odanacatib studied for osteoporosis Inhibition of the Cysteine Protease Human Cathepsin L by Triazine Nitriles: Amide···Heteroarene �-Stacking Interactions and Chalcogen Bonding in the S3 Pocket Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB Cysteine protease inhibition by azapeptide esters Molecular docking of cathepsin L inhibitors in the binding site of papain Cathepsin L expression is up-regulated by hypoxia in human melanoma cells: Role of its 5 -untranslated region Multiple Cathepsins Promote Pro-IL-1beta Synthesis and NLRP3-Mediated IL-1beta Activation Activity-based protein profiling: From enzyme chemistry to proteomic chemistry Finding enzymes that are actively involved in cancer Activity-based probes for protein tyrosine phosphatases Global analysis of protein tyrosine phosphatase activity with ultra-sensitive fluorescent probes Optimization of a Protease Activated Probe for Optical Surgical Navigation Preclinical Evaluation of Cathepsin-Based Fluorescent Imaging System for Cytoreductive Surgery Activity-based probes that target diverse cysteine protease families Functional imaging of proteases: Die Pharm Dipeptidylpeptidase IV-inactivation with N-peptidyl-O-aroyl hydroxylamines Potent and selective inactivation of proteinases with N-peptidyl-O-acylhydroxylamines Reactions between dipeptidyl peptidase IV and diacyl hydroxylamines: Mechanistic investigations Potent and selective inactivation of cysteine proteinases with N-peptidyl-O-acyl hydroxylamines Novel N-peptidyl-O-acyl hydroxamates: Selective inhibitors of cysteine proteinases N-peptidyl-O-carbamoyl amino acid hydroxamates: Irreversible inhibitors for the study of the S2 specificity of cysteine proteinases -guanidino)butane] analogues as inhibitors of cysteine proteinases: Investigation of S2 subsite interactions Peptidyl (acyloxy)methanes as quiescent affinity labels for cysteine proteinases Identification of new peptide amides as selective cathepsin L inhibitors: The first step towards selective irreversible inhibitors? 64) as Inhibitors of Cysteine Proteases New Peptidic Cysteine Protease Inhibitors Derived from the Electrophilic α-Amino Acid Aziridine-2,3-dicarboxylic Acid Novel peptidyl aryl vinyl sulfones as highly potent and selective inhibitors of cathepsins L and B Development of a highly potent, selective, and cell-active inhibitor of cysteine cathepsin L-A hybrid design approach Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain Development of peptidyl α-keto-β-aldehydes as new inhibitors of cathepsin L-Comparisons of potency and selectivity profiles with cathepsin B Azepanone-based inhibitors of human cathepsin L Systematic investigation of halogen bonding in protein-ligand interactions Fluorine Scan of Inhibitors of the Cysteine Protease Human Cathepsin L: Dipolar and Quadrupolar Effects in the pi-Stacking of Fluorinated Phenyl Rings on Peptide Amide Bonds Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors A Combined Crystallographic and Molecular Dynamics Study of Cathepsin L Retrobinding Inhibitors Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney
    keywords: active; activity; authors; cathepsin b; cathepsin l; cell; class; compounds; cysteine; entry; enzyme; et al; figure; human; inhibitor; pocket; probe; scaffold; selective; selectivity; site; study; table
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        item: #90 of 156
          id: cord-282783-ps5jyjkl
      author: None
       title: Full Issue PDF
        date: 2020-09-30
       words: 15963
      flesch: 33
     summary: Transthyretin amyloid cardiomyopathy: JACC state-of-the-art review Natural his A new staging system for cardiac transthyretin amyloidosis Cardiovascular disease mortality after chemotherapy or surgery for testicular nonseminoma: a populationbased study Testicular cancer: a Mechanisms of cisplatin nephrotoxicity White-Paper-1.pdf A new equation to estimate glomerular filtration rate Crosstalk between vascular redox and calcium signaling in hypertension involves TRPM2 (Transient Receptor Potential Melastatin 2) cation channel Marked impairment of protease-activated receptor type 1-mediated vasodilation and fibrinolysis in cigarette smokers: smoking, thrombin, and vascular responses in vivo Intra-arterial substance P mediated vasodilatation in the human forearm: pharmacology, reproducibility and tolerability Role of the endothelium in the vascular effects of the thrombin receptor (protease-activated receptor type 1) in humans Vascular effects of apelin in vivo in man The vasodilator action of nebivolol in forearm vasculature of subjects with essential hypertension Fire simulation and cardiovascular health in firefighters Vascular damage in testicular cancer patients: a study on endothelial activation by bleomycin and cisplatin in vitro Antiangiointravascular ultrasound imaging for coronary thrombosis after cisplatin-based chemotherapy Caspases and calpain are independent mediators of cisplatin-induced endothelial cell necrosis Arterial events in cancer patients-the case of acute coronary thrombosis Vascular toxic effects of cancer therapies Treatmentrelated cardiovascular toxicity in long-term survivors of testicular cancer Comprehensive characterisation of the vascular effects of cisplatin-based chemotherapy in patients with testicular cancer Impact of platinum-based chemotherapy on the progression of atherosclerosis Vascular fingerprint and vascular damage markers associated with vascular events in testicular cancer patients during and after chemotherapy Cardiovascular risk in long-term survivors of testicular cancer Long-term platinum retention after platinumbased chemotherapy in testicular cancer survivors: a 20-year follow-up study Hematopoietic stem cell transplantation in Europe 2014: more than 40 000 transplants annually Reduced mortality after allogeneic hematopoietic-cell transplantation Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor Study Vascular endothelium as 'novel' target of graft-versus-host disease Pericarditis in patients with chronic graft-vs-host disease National Institutes of Health hematopoietic cell transplantation late effects initiative: The Cardiovascular Disease and Associated Risk Factors Working Group Report Prevalence of outpatient cancer treatment in the United States: estimates from the Medical Panel Expenditures Survey (MPES) Chemotherapy-induced cardiotoxicity: detection, prevention, and management Long-term chemotherapy-related cardiovascular morbidity Cardiovascular disease in adult survivors of childhood cancer Epirubicin versus doxorubicin: which is the anthracycline of choice for the treatment of breast cancer? Gp91phox-containing NAD(P)H oxidase increases superoxide formation by doxorubicin and NADPH Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin Redox cycling of anthracyclines by cardiac mitochondria. However, elevations in TnI have also been observed in cancer patients receiving cancer therapy, including ICIs without any cardiotoxicities (23, 24) , thus suggesting that its utility may also be limited for the detection of iRC.
    keywords: age; anthracycline; cancer; cardiac; cardiotoxicity; cardiovascular; ccs; cell; checkpoint; chemotherapy; coronary; data; disease; doxorubicin; endothelial; events; factors; failure; heart; ibrutinib; immune; myocarditis; patients; risk; study; survivors; table; term; therapy; treatment; years
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        item: #91 of 156
          id: cord-287136-3cml1shh
      author: Dopfer, Christian
       title: COVID-19 related reduction in pediatric emergency healthcare utilization – a concerning trend
        date: 2020-09-07
       words: 3804
      flesch: 45
     summary: key: cord-287136-3cml1shh authors: Dopfer, Christian; Wetzke, Martin; Zychlinsky Scharff, Anna; Mueller, Frank; Dressler, Frank; Baumann, Ulrich; Sasse, Michael; Hansen, Gesine; Jablonka, Alexandra; Happle, Christine title: COVID-19 related reduction in pediatric emergency healthcare utilization – a concerning trend date: 2020-09-07 journal: BMC Pediatr DOI: 10.1186/s12887-020-02303-6 sha: doc_id: 287136 cord_uid: 3cml1shh BACKGROUND: We examined the impact of the pandemic on pediatric emergency healthcare utilization.
    keywords: covid-19; diseases; emergency; fig; healthcare; pandemic; patients; pediatric
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        item: #92 of 156
          id: cord-287684-z3l9tsir
      author: Johnson, Sonia
       title: Impact on mental health care and on mental health service users of the COVID-19 pandemic: a mixed methods survey of UK mental health care staff
        date: 2020-08-28
       words: 6656
      flesch: 42
     summary: key: cord-287684-z3l9tsir authors: Johnson, Sonia; Dalton-Locke, Christian; Vera San Juan, Norha; Foye, Una; Oram, Sian; Papamichail, Alexandra; Landau, Sabine; Rowan Olive, Rachel; Jeynes, Tamar; Shah, Prisha; Sheridan Rains, Luke; Lloyd-Evans, Brynmor; Carr, Sarah; Killaspy, Helen; Gillard, Steve; Simpson, Alan title: Impact on mental health care and on mental health service users of the COVID-19 pandemic: a mixed methods survey of UK mental health care staff date: 2020-08-28 journal: The COVID-19 pandemic has potential to disrupt and burden the mental health care system, and to magnify inequalities experienced by mental health service users.
    keywords: care; community; covid-19; crisis; health; mental; pandemic; people; service; staff; table; users; working
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        item: #93 of 156
          id: cord-287711-gw8mgg4m
      author: Junter, Guy-Alain
       title: Cellulose-based virus-retentive filters: a review
        date: 2017-06-01
       words: 11727
      flesch: 24
     summary: Micro filters with 0.1-0.2 lm pore size (Koenderman et al. 2012; Terpstra et al. 2007; , but also 75N (Dichtelmüller et al. 2012 ) and 35N (Chtourou et al. 2007) . Both 20N (Caballero et al. 2014; Furuya et al. 2006; Gröner 2014) and 15N (Caballero et al. 2014; Roberts et al. 2010; Terpstra et al. 2007; Planova filters and their combination (Gröner et al. 2012; Koenderman et al. 2012 ) showed effective virus removal over a wide range of viral particle sizes (Table 1) .
    keywords: air; cellulose; concentration; detection; efficiency; et al; fiber; filters; filtration; masks; media; membrane; methods; particles; pore; process; recovery; removal; samples; size; step; studies; table; virus; viruses; volume; water; water samples
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        item: #94 of 156
          id: cord-288644-ywaefpe8
      author: Rodon, Jordi
       title: Pre-clinical search of SARS-CoV-2 inhibitors and their combinations in approved drugs to tackle COVID-19 pandemic
        date: 2020-10-20
       words: 7597
      flesch: 44
     summary: To detect any drugassociated cytotoxic effect, Vero E6 cells were equally cultured in the presence of increasing drug concentrations, but in the absence of virus. A constant concentration of a clinical isolate of SARS-CoV-2 (ID EPI_ISL_510689) was mixed with increasing concentrations of hydroxychloroquine and added to Vero E6 cells.
    keywords: activity; cells; cov-2; drugs; effect; inhibitors; sars; supp; table; vero
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        item: #95 of 156
          id: cord-288842-qr8bzp4r
      author: Kutuzova, Galina D.
       title: Gene expression profiles in rat intestine identify pathways for 1,25-dihydroxyvitamin D(3) stimulated calcium absorption and clarify its immunomodulatory properties
        date: 2004-12-15
       words: 8899
      flesch: 46
     summary: To specify the role of vitamin D in intestinal calcium absorption and to identify new genes that may be involved in these processes, we have used highdensity oligonucleotide arrays and studied the dynamics of gene expression in rat duodenum within 6 h postintrajugular injection of 1,25-(OH) 2 D 3 . key: cord-288842-qr8bzp4r authors: Kutuzova, Galina D.; DeLuca, Hector F. title: Gene expression profiles in rat intestine identify pathways for 1,25-dihydroxyvitamin D(3) stimulated calcium absorption and clarify its immunomodulatory properties date: 2004-12-15 journal: Arch Biochem Biophys DOI: 10.1016/j.abb.2004.09.004 sha: doc_id: 288842 cord_uid: qr8bzp4r Microarray technology has been used to discover 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)) induced gene expression changes in rat small intestine in vivo.
    keywords: absorption; atpase; calcium; cells; data; expression; fold; genes; increase; intestine; proteins; regulation; table; time; transport; vitamin
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        item: #96 of 156
          id: cord-290788-6y0vjhux
      author: Wang, Qihui
       title: Isolation of Monoclonal Antibodies from Zika Virus-Infected Patient Samples
        date: 2020-05-05
       words: 4089
      flesch: 71
     summary: In the presence of antigens, memory B cells undergo affinity maturation, and their B-cell receptors have increased affinities for the antigen. Studies on memory B cells after smallpox vaccination in humans indicated that antigenspecific memory B cells initially declined postimmunization (1 year) but then reached a plateau~tenfold lower than peak and were stably maintained for >50 years after vaccination [20] .
    keywords: cells; mabs; memory; min; primers; table; virus; zika
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        item: #97 of 156
          id: cord-291032-l813q689
      author: Shupler, M.
       title: COVID-19 Lockdown in a Kenyan Informal Settlement: Impacts on Household Energy and Food Security
        date: 2020-05-29
       words: 4673
      flesch: 48
     summary: The high cost of LPG refills (85% of LPG households used 6 kg cylinders) explains the appeal of small incremental payments via PAYG smart-meter technology among participants (Table 2 ). key: cord-291032-l813q689 authors: Shupler, M.; Mwitari, J.; Gohole, A.; Anderson de Cuevas, R.; Puzzolo, E.; Cukic, I.; Nix, E.; Pope, D. title: COVID-19 Lockdown in a Kenyan Informal Settlement: Impacts on Household Energy and Food Security date: 2020-05-29 journal: nan DOI: 10.1101/2020.05.27.20115113 sha: doc_id: 291032 cord_uid: l813q689 A COVID-19 lockdown may impact household fuel use and food security for ~700 million sub-Saharan Africans who rely on polluting fuels (e.g. wood, kerosene) for household energy and typically work in the informal economy.
    keywords: cooking; covid-19; fuel; health; households; kerosene; license; lockdown; lpg; preprint; table
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        item: #98 of 156
          id: cord-292698-w7wrwj95
      author: Rothstein, Rachel
       title: School Nurses on the Front Lines of Healthcare: The Approach to Maintaining Student Health and Wellness During COVID-19 School Closures
        date: 2020-06-25
       words: 3057
      flesch: 47
     summary: While the term social distancing is likely new to many, the concept of school closures as a tool for reducing spread of infectious diseases originated long before the COVID-19 pandemic. While the current durations of school closures exceed those of other infectious disease outbreaks in recent history, consistent are the challenges to maintaining student health and wellness in light of closures.
    keywords: care; children; closures; covid-19; health; school; table; website
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        item: #99 of 156
          id: cord-293857-o8rlqsq5
      author: Ghosh, Arun K.
       title: Organic Carbamates in Drug Design and Medicinal Chemistry
        date: 2015-01-07
       words: 18292
      flesch: 35
     summary: Improved oral bioavailability, dose proportionality, and colonic absorption compared with gabapentin in rats and monkeys ] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: I. Design, synthesis, enzymatic conversion to gabapentin, and transport by intestinal solute transporters Clinical pharmacokinetics of XP13512, a novel transported prodrug of gabapentin Hydrolysis of capecitabine to 5′-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue Rational development of capecitabine Capecitabine: a review Profound and sustained inhibition of platelet aggregation by Fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men Bis-tetrahydrofuran: a privileged ligand for darunavir and a new generation of hiv protease inhibitors that combat drug resistance Enhancing protein backbone bindinga fruitful concept for combating drug-resistant HIV Crystal structure of an in vivo HIV-1 protease mutant in complex with saquinavir: insights into the mechanisms of drug resistance Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands Anti-HIV protease inhibitor Darunavir Inhibitors of HIV-1 protease containing the novel and potent (R)-(hydroxyethyl)sulfonamide isostere Design and synthesis of Amprenavir, a novel HIV protease inhibitor The development of cyclic sulfolanes as novel and high-affinity P2 ligands for HIV-1 protease inhibitors Nonpeptidal P2 ligands for HIV protease inhibitors: structure-based design, synthesis, and biological evaluation Structure-based design of non-peptide HIV protease inhibitors Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114 A potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site Potent inhibition of HIV-1 replication by novel nonpeptidyl small molecule inhibitors of protease dimerization Design of HIV-1 protease inhibitors active on multidrug-resistant virus Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drugresistant HIV Darunavir, a new PI with dual mechanism: from a novel drug design concept to new hope against drug-resistant HIV Stereoselective photochemical 1,3-dioxolane addition to 5-alkoxymethyl-2(5H)-furanone: synthesis of bis-tetrahydrofuranyl ligand for HIV protease inhibitor UIC-94017 (TMC-114) Synthesis and optical resolution of high affinity P2-ligands for HIV-1 protease inhibitors A novel bistetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI), GRL-98065, is potent against multiple-PI-resistant human immunodeficiency virus in vitro Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: the discovery of GW0385 Suppression of HIV-1 protease inhibitor resistance by phosphonate-mediated solvent anchoring TMC310911, a novel human immunodeficiency virus type 1 protease inhibitor, shows in vitro an improved resistance profile and higher genetic barrier to resistance compared with current protease inhibitors Flexible cyclic ethers/polyethers as novel P2-ligands for HIV-1 protease inhibitors: design, synthesis, biological evaluation, and protein-ligand X-ray studies Design and synthesis of potent HIV-1 protease inhibitors incorporating hexahydrofuropyranol-derived high affinity P(2) ligands: structure-activity studies and biological evaluation Probing multidrug-resistance and protein-ligand interactions with oxatricyclic designed ligands in HIV-1 protease inhibitors GRL-04810 and GRL-05010, difluoride-containing nonpeptidic HIV-1 protease inhibitors (PIs) that inhibit the replication of multi-PI-resistant HIV-1 in vitro and possess favorable lipophilicity that may allow blood-brain barrier penetration The discovery of β-secretase and development toward a clinical inhibitor for AD: an exciting academic collaboration Design of potent inhibitors for human brain memapsin 2 (βsecretase) A wide variety of human rhinovirus 3C (HRV 3C) protease inhibitors were developed by the incorporation of α,βunsaturated carbonyl moieties as warheads.
    keywords: acid; activity; amide; amines; bond; carbamate; carbonates; design; development; drug; enzyme; figure; group; hcv; hiv; human; hydrogen; hydrolysis; inhibitors; method; novel; prodrugs; protease; protease inhibitors; reaction; rearrangement; scheme; secretase; serine; structure; synthesis; table; treatment; virus
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        item: #100 of 156
          id: cord-295028-vlj2ay6d
      author: Zhao, Hui
       title: Probability estimation model for the cancellation of container slot booking in long-haul transports of intercontinental liner shipping services
        date: 2020-08-08
       words: 10323
      flesch: 50
     summary: Although the airline ticket cancellation studies could provide some enlightenment for container slot cancellation modeling, estimating the probability of cancellation in container slot booking is a new and worthy research topic because of the following exclusive features. Thre are two situations of slot booking cancellations.
    keywords: booking cancellation; booking time; bookings; cancellation; container; container shipping; container slot; data; function; hazard; model; shipping; slot booking; time
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        item: #101 of 156
          id: cord-295689-me50th40
      author: Cox, E.
       title: Effect of antisecretory drugs on experimentally induced weanling diarrhoea in piglets
        date: 1989
       words: 3357
      flesch: 42
     summary: The decrease in body temperature observed in control piglets after TGE virus and ETEC inoculation was not influenced by the calcium antagonist, whereas administration of the b-adrenergic antagonist resulted in an increase in temperature (Table II) . As previously described (Cox, Charlier and Houvenaghel, 1988) , piglets developed diarrhoeic faeces during the chloramphenicol pre-treatment period (Figure 1, day 3) .
    keywords: chlorpromazine; clonidine; diarrhoea; etec; piglets; treatment; virus
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        item: #102 of 156
          id: cord-297742-0pfrk5uk
      author: Simusika, Paul
       title: An evaluation of the Zambia influenza sentinel surveillance system, 2011–2017
        date: 2020-01-13
       words: 5506
      flesch: 39
     summary: The World Health Organization (WHO) recommends that established influenza surveillance systems undergo a comprehensive evaluation periodically, beginning 1-2 years after implementation in order to ascertain how well the system fulfills its purposes key: cord-297742-0pfrk5uk authors: Simusika, Paul; Tempia, Stefano; Chentulo, Edward; Polansky, Lauren; Mazaba, Mazyanga Lucy; Ndumba, Idah; Mbewe, Quinn K.; Monze, Mwaka title: An evaluation of the Zambia influenza sentinel surveillance system, 2011–2017 date: 2020-01-13 journal: BMC Health Serv Res DOI: 10.1186/s12913-019-4884-5 sha: doc_id: 297742 cord_uid: 0pfrk5uk BACKGROUND: Over the past decade, influenza surveillance has been established in several African countries including Zambia.
    keywords: data; evaluation; illness; indicators; influenza; performance; score; surveillance; system; zambia
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        item: #103 of 156
          id: cord-301150-41lfsedz
      author: Sardar, Tridip
       title: Assessment of Lockdown Effect in Some States and Overall India: A Predictive Mathematical Study on COVID-19 Outbreak
        date: 2020-07-08
       words: 2223
      flesch: 41
     summary: Forecast based on 20% reduction in current lockdown rate: we followed the same 206 procedure as previous two scenarios with 20% decrement in the estimate of lockdown rate 207 (see Table 1 and Table 2 ) to obtained the forecast during the mentioned time period. Forecast based on 30% reduction in current lockdown rate: we followed the same 209 procedure as previous three scenarios with 30% decrement in the estimate of lockdown 210 rate (see Table 1 and Table 2 ) to obtain the forecast during the mentioned time period.
    keywords: lockdown; model; rate; reduction; table
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        item: #104 of 156
          id: cord-302414-g5onwhg1
      author: Tahir ul Qamar, Muhammad
       title: Reverse vaccinology assisted designing of multiepitope-based subunit vaccine against SARS-CoV-2
        date: 2020-09-16
       words: 6792
      flesch: 43
     summary: Interaction and binding patterns between receptor and vaccine protein were stable and higher. The quality score beyond the usual range of native proteins indicates a possible error in protein structure.
    keywords: analysis; cell; construct; coronavirus; cov-2; covid-19; epitopes; file; immune; mesv; prediction; protein; sars; server; structure; vaccine
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        item: #105 of 156
          id: cord-302543-ipaoge55
      author: Sadana, Ajit
       title: Chapter 11 Detection of Biomarkers for Different Diseases on Biosensor Surfaces Part II
        date: 2015-12-31
       words: 10057
      flesch: 55
     summary: Point-of-care biosensor systems for cancer diagnostics/prognostics (Sofer et al., 2006) . Boehm et al. (1997) indicate that it is secreted by immune cells in response to various pathogens.
    keywords: binding; biosensor; d f1; d f2; data; dissociation; et al; fractal analysis; fractal dimension; increase; k d; rate coefficient; surface
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        item: #106 of 156
          id: cord-303300-89v1weno
      author: Sauter, Marian
       title: Building, Hosting and Recruiting: A Brief Introduction to Running Behavioral Experiments Online
        date: 2020-04-24
       words: 5293
      flesch: 44
     summary: The First Single Application for the Entire DevOps Lifecycle-GitLab | GitLab Just another tool for online studies (JATOS): An easy solution for setup and management of web servers supporting online studies Another Tool for Online Studies Subject pool recruitment procedures: Organizing experiments with ORSEE Sona Systems: Cloud-based Subject Pool Software for Universities Running experiments on amazon mechanical turk Evaluating Amazon's mechanical turk as a tool for experimental behavioral research Prolific | Online Participant Recruitment for Surveys and Market Research Prolific.ac-A subject pool for online experiments Panel Management Software-Recruit, Target, & Save Money | Qualtrics Survey Solutions for Researchers Introduction to Online Experiments The pitfall of experimenting on the web: How unattended selective attrition leads to surprising (yet false) research conclusions López-de-Ipiña, D. Presentation accuracy of the web revisited: Animation methods in the HTML5 era Presentation and response timing accuracy in Adobe Flash and HTML5/JavaScript Web experiments Best practices: Two Web-browser-based methods for stimulus presentation in behavioral experiments with high-resolution timing requirements The Timing Mega-Study: Comparing a Range of Experiment Generators, Both Lab-Based and Online Online Timing Accuracy and Precision: A comparison of platforms, browsers, and participant's devices Online psychophysics: Reaction time effects in cognitive experiments Is There a cost to convenience? However, they found that they could collect data Finally, online experimental studies should be short.
    keywords: data; experiments; lab; online; participants; solutions; studies; study; testing; web
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        item: #107 of 156
          id: cord-304375-l5gvpat3
      author: Singh, Kamaljit
       title: 2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure–activity relationship and mode of action studies
        date: 2012-03-13
       words: 6633
      flesch: 45
     summary: Evidently, the compounds have anti-plasmodial activity in the nM range and against the CQ R strain of P. falciparum, in some cases activity was found to be even superior to CQ. Replacing the C-4 phenyl group in 10c by a methyl group to create 10m resulted in nearly 5 times increase in anti-plasmodial activity (IC 50 42.1 nM) against the CQ S strain.
    keywords: 10c; 10r; activity; anti; binding; cell; compounds; dna; drug; heme; interaction; strain; table; virus
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        item: #108 of 156
          id: cord-304869-l6a68tqn
      author: Bielińska-Wąż, Dorota
       title: Graphical and numerical representations of DNA sequences: statistical aspects of similarity
        date: 2011-08-28
       words: 15415
      flesch: 58
     summary: Though q may be easily increased up to higher-orders, as we shall see, the information about similarity sequences is specific enough up to the fourth order. Two bases belonging to different sequences, both located on the p-th positions are represented by a pair of numbers, {x p , n p }.
    keywords: alignment; bases; descriptors; dna sequences; example; fig; graphs; methods; representation; sequences; similarity; table
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        item: #109 of 156
          id: cord-304909-3wmrjlhy
      author: Wicker, L. V.
       title: Potential Pathogens Reported in Species of the Family Viverridae and Their Implications for Human and Animal Health
        date: 2016-06-30
       words: 8010
      flesch: 29
     summary: (Casanova et al., 2000; Su et al., 2013) ; and Spirometra erinaceieuropaei and Diplobothrium sp. (Colon and Patton, 2013; Su et al., 2013) ; Eimeria spp.
    keywords: animals; canine; carnivores; civet; disease; et al; health; hosts; human; organisms; palm; potential; species; spp; su et; table; transmission; virus; viverrids; wild; wildlife; zoonotic
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        item: #110 of 156
          id: cord-305378-jmcuq9c5
      author: Chen, Hui
       title: Liquid–liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA
        date: 2020-09-08
       words: 536
      flesch: 51
     summary: Assembly of severe acute respiratory syndrome coronavirus RNA packaging signal into virus-like particles is nucleocapsid dependent The initiation, propagation and dynamics of CRISPR-SpyCas9 R-loop complex Approximately 3 μL of sample were applied to glow-discharged holey carbon grids The particle size of N protein was detected by a DynaPro NanoStar (Wyatt Technology) which was equipped with a 660 nm laser, detector angle was fixed at 90°.
    keywords: information; rna
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        item: #111 of 156
          id: cord-305745-9lngdjow
      author: Solnier, Julia
       title: Flavonoids: A complementary approach to conventional therapy of COVID-19?
        date: 2020-09-18
       words: 9550
      flesch: 32
     summary: In docking studies, Jo et al. showed that the additional 8-hydroxyl group of herbacetin seems to be crucial for its high binding affinity to the polar S1 site and the hydrophobic S2 site of SARS-CoV 3CLpro In a following docking study, Jo et al. showed that a rhamnose substitution instead of glucose (in quercetin 3-b-glucoside), results in a stronger binding with MERS-CoV 3CLpro (Jo et al. 2019) .
    keywords: activity; antiviral; compounds; coronavirus; cov; cov-2; et al; flavonoids; inhibition; inhibitors; mers; plpro; proteases; quercetin; sars; studies; table
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        item: #112 of 156
          id: cord-305900-ht7hb2rc
      author: van den Brand, Judith M. A.
       title: Comparison of Temporal and Spatial Dynamics of Seasonal H3N2, Pandemic H1N1 and Highly Pathogenic Avian Influenza H5N1 Virus Infections in Ferrets
        date: 2012-08-08
       words: 9469
      flesch: 44
     summary: (DOC) Pathology of human influenza revisited Comparison of the pathology caused by H1N1, H5N1, and H3N2 influenza viruses The pathology of influenza virus infections Number of human H5N1 cases Comparative pathology of select agent influenza a virus infections Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals The ferret: an animal model to study influenza virus Efficacy of vaccination with different combinations of MF59-adjuvanted and non-adjuvanted seasonal and pandemic influenza vaccines against pandemic H1N1 (2009) influenza in ferrets Local innate immune responses and influenza virus transmission and virulence in ferrets Pathogenesis of avian influenza A (H5N1) viruses in ferrets Pathogenesis and transmission of triple-reassortant swine H1N1 influenza viruses isolated before the 2009 H1N1 pandemic Modeling host responses in ferrets during A/California/07/2009 influenza infection Course of seasonal influenza A/Brisbane/59/07 H1N1 infection in the ferret Comparative pathology in ferrets infected with H1N1 influenza A viruses isolated from different hosts Virulence differences of closely related pandemic 2009 H1N1 isolates correlate with increased inflammatory responses in ferrets Interactions of surfactant protein A with influenza A viruses: binding and neutralization Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques Severity of pneumonia due to new H1N1 influenza virus in ferrets is intermediate between that due to seasonal H1N1 virus and highly pathogenic avian influenza H5N1 virus Alveolar edema fluid clearance and acute lung injury Upregulation of alveolar epithelial fluid transport after subacute lung injury in rats from bleomycin Estrogen regulation of nitric oxide and inducible nitric oxide synthase (iNOS) in immune cells: implications for immunity, autoimmune diseases, and apoptosis Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia Avian influenza A (H5N1) infection in eastern Turkey in 2006 Update on avian influenza A (H5N1) virus infection in humans Avian influenza (H5N1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammals Inefficient transmission of H5N1 influenza viruses in a ferret contact model Pathogenesis of Influenza A/H5N1 virus infection in ferrets differs between intranasal and intratracheal routes of inoculation Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004 Depletion of lymphocytes and diminished cytokine production in mice infected with a highly virulent influenza A (H5N1) virus isolated from humans Influenza This is because influenza virus infection is a highly dynamic process, both temporally and spatially.
    keywords: alveolar; antigen; cells; dpi; expression; ferrets; figure; h5n1; infection; influenza; table; tract; virus
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        item: #113 of 156
          id: cord-306189-ugxou9z1
      author: Bherwani, Hemant
       title: Valuation of air pollution externalities: comparative assessment of economic damage and emission reduction under COVID-19 lockdown
        date: 2020-06-10
       words: 4610
      flesch: 48
     summary: Population for the years of valuation is estimated to evaluate the extent of health damages due to AP in a particular city. The daily mean of PM 2.5 , PM 10 and daily averages for NO 2 during the month of lockdown days in 2020 and the same month for the previous year 2019 was found beyond the acceptable limit, thereby health damage assessment is carried out by certain set of formulas (Eqs. (1)- (3))
    keywords: air; cities; damages; health; lockdown; morbidity; mortality; table
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        item: #114 of 156
          id: cord-306535-j26eqmxt
      author: Robertson, Matthew J.
       title: Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets
        date: 2020-08-19
       words: 16775
      flesch: 43
     summary: [28] to create a comprehensive database of mouse gene symbols orthologous to human genes and vice versa. The majority of identified genes were not from a traditional drug target family like kinases or enzymes.
    keywords: analysis; candidate genes; cell; ces5a; datasets; epididymis; expression; fig; file; genes; human; male; mice; mouse; mouse genes; number; protein; reproductive; rna; samples; seq; specific; sperm; spint3; studies; table; testis; tissue; tract
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        item: #115 of 156
          id: cord-307338-4nta9b6w
      author: Slomka, Marek J.
       title: Original Article: Real time reverse transcription (RRT)‐polymerase chain reaction (PCR) methods for detection of pandemic (H1N1) 2009 influenza virus and European swine influenza A virus infections in pigs
        date: 2010-08-17
       words: 8001
      flesch: 52
     summary: The first variant ('perfect match' M gene RRT PCR) included modification of the AIV reverse primer used by Spackman et al. 38 to provide a perfect match primer (reverse modified, i.e. 'Rev-mod') with the corresponding region in the M gene of H1N1v isolates ( The second variant ('combo' M gene RRT PCR) included an equimolar mix of the original AIV reverse primer plus the above Rev-mod primer, with each included at 0AE2 lm final concentration. These were designed to investigate any UK clinical specimens that may be positive by M gene RRT PCR but negative by 'H1-118' RRT PCR and negative by VI.
    keywords: gene; h1n1v; influenza; match; pcr; pigs; rrt; rrt pcr; swine; table
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        item: #116 of 156
          id: cord-307632-x9bxnrtn
      author: Wu, Zhiqiang
       title: Comparative analysis of rodent and small mammal viromes to better understand the wildlife origin of emerging infectious diseases
        date: 2018-10-03
       words: 7235
      flesch: 46
     summary: Recent reports of rodent viruses have enabled new hypotheses regarding the evolution of hepaciviruses and the origin of coronaviruses (CoVs) and picornaviruses (PicoVs) such as hepatitis A virus [26] We identified diverse HVs and AreVs located in different phylogenetic positions that indicate the presence of novel viruses in new hosts such as Caryomys eva (RtCe-HV/NX2015), Eothenomys melanogaster (RtCl-HV/ GZ2015), and Dipus sagitta (RtDs-HV/IM2014 and RtDs-AreV/IM2014).
    keywords: china; families; family; figure; file; hosts; identity; novel; reads; rodent; samples; sequence; species; table; viral; viruses
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        item: #117 of 156
          id: cord-313355-166b6fep
      author: Zhang, Xiao-Jing
       title: In-hospital Use of Statins is Associated with a Reduced Risk of Mortality among Individuals with COVID-19
        date: 2020-06-24
       words: 8470
      flesch: 38
     summary: The IL-6 in the statin group showed a lower level at admission and had a less increase than that of non-statin group in the entire duration of follow-up ( Figure 3B) . For the mixed Cox analysis, the statin versus non-statin group ratio was paired at 1:4.
    keywords: arb; covid-19; cox; disease; group; increase; individuals; model; statin; table; time; treatment
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        item: #118 of 156
          id: cord-314372-knhkdlq7
      author: Kanduc, Darja
       title: Massive peptide sharing between viral and human proteomes
        date: 2008-06-05
       words: 4370
      flesch: 39
     summary: a Analogous to viral proteomes in size (see Table 1 ), and composed by set of human proteins as detailed in Table 3 overlap for 633,229 times (see data from Tables 4 and 5 , respectively). Specifically, the study was designed to answer two main questions: (i) what is the quantitative dimension of shortpeptide sequence sharing between viruses and human proteomes?
    keywords: amino; human; peptide; proteins; proteome; sub; table; viral
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        item: #119 of 156
          id: cord-314908-kp2jznwb
      author: Roczniewska, Marta
       title: I believe I can craft! introducing Job Crafting Self-Efficacy Scale (JCSES)
        date: 2020-08-10
       words: 9303
      flesch: 49
     summary: JCSE explained unique variance in job crafting behaviors over and above general self-efficacy, and was more important in predicting job crafting than contextual factors. In the meta-analysis, general self-efficacy has been positively linked with job crafting behaviors [3] ; however, its predictive power was low to medium, and differed for distinct crafting behaviors.
    keywords: crafting; demands; efficacy; factor; jcse; job; model; resources; self; study
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        item: #120 of 156
          id: cord-315193-z6v6s46n
      author: Adhikari, Nilanjan
       title: Structural Insight Into the Viral 3C-Like Protease Inhibitors: Comparative SAR/QSAR Approaches
        date: 2017-07-14
       words: 9980
      flesch: 52
     summary: Three noncanonical M pro cleavage sites are observed in SARS coronavirus polyproteins having Val, Met, or Phe amino acid residues at P2 position whereas the same cleavage site is found dissimilar in other coronaviruses. Short hairpin RNA (shRNA) may be useful to target the N gene sequence of SARS coronavirus and to inhibit shRNA of SARS-CoV antigen expression (Tao et al., 2005; Zhai et al., 2007) .
    keywords: 3cl; activity; compounds; cov; et al; inhibitors; model; pro; protease; qsar; sars; table
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        item: #121 of 156
          id: cord-315931-kc8gnj6z
      author: Klempt, Petr
       title: Performance of Targeted Library Preparation Solutions for SARS-CoV-2 Whole Genome Analysis
        date: 2020-09-29
       words: 4815
      flesch: 40
     summary: Also, the viral load in a sample (corresponding to sample Ct value ≤ 23.29 or positive control value ≤ 25.84) showed to be the limiting factor in case of each workflow, samples with higher Ct value resulted in either poor genome coverage (NEB+Twist workflow and Illumina workflow) or in absence of expected library preparation product (Paragon workflow). The samples with higher Ct value resulted in low genome coverage-NEB+Twist workflow and Illumina workflow or in absence of expected library preparation product-Paragon workflow.
    keywords: cov-2; coverage; reads; samples; sars; table; value
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        item: #122 of 156
          id: cord-316983-h4mtpcyc
      author: Mathé-Hubert, Hugo
       title: Comparative venomics of Psyttalia lounsburyi and P. concolor, two olive fruit fly parasitoids: a hypothetical role for a GH1 β-glucosidase
        date: 2016-10-25
       words: 8298
      flesch: 44
     summary: In the absence of VLPs and PDVs, secreted venom proteins are likely the main maternal actors of parasitism success of Psyttalia species. Identified venom proteins.
    keywords: concolor; ervi; family; fig; function; host; lounsburyi; parasitoid; proteins; psyttalia; role; species; tables; unisequences; venom; wasp
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        item: #123 of 156
          id: cord-318339-j35w1vsw
      author: Stockman, Lauren J
       title: SARS: Systematic Review of Treatment Effects
        date: 2006-09-12
       words: 4389
      flesch: 47
     summary: The World Health Organization (WHO) expert panel on SARS treatment requested a systematic review and comprehensive summary of treatments used for SARS-infected patients in order to guide future treatment and identify priorities for research. Despite an extensive literature reporting on SARS treatments, it was not possible to determine whether treatments benefited patients during the SARS outbreak.
    keywords: patients; ribavirin; sars; studies; table; treatment; vitro
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        item: #124 of 156
          id: cord-319460-n4ezxnjc
      author: Bertasio, Cristina
       title: Porcine Epidemic Diarrhea Virus Shedding and Antibody Response in Swine Farms: A Longitudinal Study
        date: 2016-12-15
       words: 5929
      flesch: 47
     summary: QPCR and clinical data were useful in understanding the dynamics of PEDV infections and, therefore, in implementing appropriate control measures. None of the farms had reported PEDV infections prior to this study, and thus, we can surmise that the sows had been recently infected at the time of their enrollment in the study, while piglets were infected after birth, through contact with infected sows.
    keywords: animals; diarrhea; epidemic; farms; pedv; piglets; porcine; sows; study; table; virus
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        item: #125 of 156
          id: cord-320208-uih4jf8w
      author: Li, Diya
       title: Modeling Spatiotemporal Pattern of Depressive Symptoms Caused by COVID-19 Using Social Media Data Mining
        date: 2020-07-10
       words: 8953
      flesch: 53
     summary: We assessed the level of stress expressed in COVID-19 related tweets by integrating a lexicon-based method derived from established clinical assessment questionnaire PHQ-9 Even though our datasets were preprocessed and selected with entities on COVID-19 related topic, some of the tweets might be outside of the topic or are influenced by other objective factors.
    keywords: accuracy; algorithm; analysis; assessment; covid-19; data; number; phq; results; stress; symptoms; topic; tweets; twitter; words
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        item: #126 of 156
          id: cord-320591-re99v1qt
      author: Le, Thanh Ninh
       title: Bioactive Compounds and Bioactivities of Brassica oleracea L. var. Italica Sprouts and Microgreens: An Updated Overview from a Nutraceutical Perspective
        date: 2020-07-27
       words: 8198
      flesch: 30
     summary: Agriculture (Polnohospodárstvo) Response surface optimization and identification of isothiocyanates produced from broccoli sprouts Free radical scavenging, antiproliferative activities and profiling of variations in the level of phytochemicals in different parts of broccoli (Brassica oleracea italica) Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract Optimisation of enzymatic production of sulforaphane in broccoli sprouts and their total antioxidant activity at different growth and storage days Comparative Study of Predominant Phytochemical Compounds and Proapoptotic Potential of Broccoli Sprouts and Florets Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells Effect of broccoli sprouts on thyroid function, haematological, biochemical, and immunological parameters in rats with thyroid imbalance Antiproliferative Effect of Bioaccessible Fractions of Four Brassicaceae Microgreens on Human Colon Cancer Cells Linked to Their Phytochemical Composition Sorting out the value of cruciferous sprouts as sources of bioactive compounds for nutrition and health Phenolic acids: Natural versatile molecules with promising therapeutic applications Effect of bioaccessibility of phenolic compounds on in vitro anticancer activity of broccoli sprouts Influence of Sodium and Maturity Stage on the Antioxidant Properties of Cauliflower and Broccoli Sprouts Phenolic profile and antioxidant activity in selected seeds and sprouts Energy Regulated Nutritive and Antioxidant Properties during the Germination and Sprouting of Broccoli Sprouts (Brassica oleracea var. It could be summarized that glucosinolates and related compounds are the major group of phytochemicals investigated in broccoli sprouts and microgreens, although phenolic compounds have also been analyzed in many studies ( Figure 2 ).
    keywords: activity; antioxidant; broccoli; broccoli sprouts; cancer; cells; compounds; effects; food; glss; glucosinolates; health; microgreens; seedlings; sprouts; studies; sulforaphane; vivo
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        item: #127 of 156
          id: cord-321000-3jd2gn73
      author: Karra, Nour
       title: A Case of Hemophagocytic Lymphohistiocytosis Associated With Mediterranean Spotted Fever in a Healthy 29-Year-Old Female
        date: 2020-08-13
       words: 3082
      flesch: 34
     summary: Second, many diagnostic criteria are nonspecific (fever, cytopenias, hypofibrinogenemia) and may be encountered Contrarily, HLH patients frequently exhibit findings other than those included in the diagnostic criteria (hypoalbuminemia, elevated liver enzymes, coagulopathy). An increasing number of acquired HLH cases have been reported in recent years [3] .
    keywords: cases; diagnosis; fever; hlh; lymphohistiocytosis; rickettsia; syndrome; treatment
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        item: #128 of 156
          id: cord-322756-ouvn71r9
      author: Chow, Michael Y.T.
       title: Inhaled RNA Therapy: From Promise to Reality
        date: 2020-09-04
       words: 7289
      flesch: 36
     summary: In this review, we highlight recent developments in pulmonary RNA delivery systems with the use of nonviral vectors. In this review, we highlight recent developments in pulmonary RNA delivery systems with the use of nonviral vectors.
    keywords: administration; cell; delivery; gene; lung; mrna; naked; pulmonary; rna; sirna; studies; table; therapy; transfection; use; vectors
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        item: #129 of 156
          id: cord-324823-bw2x9h45
      author: Little, Mark P.
       title: Pneumonia after bacterial or viral infection preceded or followed by radiation exposure - a reanalysis of older radiobiological data and implications for low dose radiotherapy for COVID-19 pneumonia
        date: 2020-10-01
       words: 4159
      flesch: 40
     summary: (8) in various subgroups risks were assessed in relation to radiation dose administered after inoculation or dose before inoculation. In the Swiss mice data of Hale and Stoner (26) there is no overall trend (p>0.2) of mortality with radiation dose given before inoculation with type III pneumococcus.
    keywords: data; dose; inoculation; pneumonia; radiation; table
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        item: #130 of 156
          id: cord-328562-g5i838b3
      author: Niles, Meredith T.
       title: The Early Food Insecurity Impacts of COVID-19
        date: 2020-07-15
       words: 5003
      flesch: 40
     summary: [CrossRef] 2. United Nations Food and Agriculture Organization United Nations Food and Agriculture Organization Household Food Security in the United States Incremental health care costs associated with food insecurity and chronic conditions among older adults Food Insecurity and Health Care Expenditures in the United States Food insecurity and health outcomes Food insecurity status and mortality among adults in Ontario Association between household food insecurity and annual health care costs Food insecurity, healthcare utilization, and high cost: A longitudinal cohort study Prevalence of US Food Insecurity Is Related to Changes in Unemployment, Inflation, and the Price of Food Unemployment and household food hardship in the economic recession United States Department of Labor. Screening for food insecurity and providing resources now may reduce short-and long-term consequences, including the potential long-term impacts on child health outcomes associated with the duration of household food insecurity [35] and higher health care expenditures associated with food insecurity [9] .
    keywords: access; assistance; covid-19; food; households; insecurity; programs
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        item: #131 of 156
          id: cord-329890-wg23sa1u
      author: Quah, Stella R.
       title: Public image and governance of epidemics: Comparing HIV/AIDS and SARS
        date: 2007-02-28
       words: 9741
      flesch: 45
     summary: In: Plenary address by Director of HIV/AIDS, WHO at the seventh international congress on AIDS in Asia and the Pacific World Health Organization [WHO] position statement on condoms and HIV prevention The politics of emerging and resurgent infectious diseases. I test two related assumptions: (1) a higher perception of disease severity and personal susceptibility to SARS as compared to HIV/AIDS, contributed to the higher effectiveness of SARS prevention efforts; (2) the second assumption is two-fold: (a) in contrast to SARS, the overall negative social 'image' of HIV/AIDS as a disease associated with particular types of individuals tends to weaken people's perception of susceptibility; (b) correspondingly, low perceived susceptibility tends to discourage public support for robust preventive efforts at the community level.
    keywords: aids; analysis; community; disease; health; hiv; image; people; prevention; public; respondents; sars; severity; susceptibility
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        item: #132 of 156
          id: cord-329999-flzqm3wh
      author: Buchanan, Tom
       title: Why do people spread false information online? The effects of message and viewer characteristics on self-reported likelihood of sharing social media disinformation
        date: 2020-10-07
       words: 13823
      flesch: 47
     summary: Social media disinformation is very widely used as a tool of influence: computational propaganda has been described as a pervasive and ubiquitous part of modern everyday life [8] . Having shared material known to be untrue at the time (Table 6 ) was significantly predicted by lower Agreeableness and lower age.
    keywords: analysis; disinformation; facebook; likelihood; literacy; material; media; participants; people; sharing; stories; studies; study
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        item: #133 of 156
          id: cord-333631-vk3h2qau
      author: Tsoungui Obama, H. C. J.
       title: Preventing COVID-19 spread in closed facilities by regular testing of employees - an efficient intervention in long-term care facilities and prisons
        date: 2020-10-14
       words: 4482
      flesch: 51
     summary: We study the impact of testing employees in LTCFs or incarceration facilities to protect 68 immobile risk groups from COVID-19 infections using an extended SEIR model, i.e., by 69 a deterministic compartmental model of ordinary differential equations. Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges Clinical features of patients infected with 2019 novel coronavirus in Wuhan The possible immunological pathways for the variable immunopathogenesis of COVID-19 infections among healthy adults, elderly and children A systematic review of asymptomatic infections with COVID-19 Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship African journal of primary health care & family medicine Hyperbaric Oxygen Therapy in Non-ventilated COVID-19
    keywords: covid-19; employees; individuals; preprint; risk; table; testing; tests
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        item: #134 of 156
          id: cord-336119-8g37xsys
      author: Nimgampalle, Mallikarjuna
       title: Screening of Chloroquine, Hydroxychloroquine and its derivatives for their binding affinity to multiple SARS-CoV-2 protein drug targets
        date: 2020-06-24
       words: 5466
      flesch: 41
     summary: These results point to the fact that the Chloroquine Chloroquine sulfate_ChEBI_50178 À3.9 (À4.0) À4.5 À5.5 (À5.2) À5.9 (À5.1) À5.0 (À5.1) À6.0 (À5.9) À5.1 (À4.9) 4. Chloroquine pyrolidylin_ZINC1666887 À7.0 (À8.0) À5.0 À6 (À5.8) À6.6 (À5.8) À5.5 (6.0) À6.3 (À6.7) À5.7 (À3.7) 5. Chloroquine mustard_ZINC5751278 À5.4 (À6.9) À4.2 À5.8 (À5.2) À5.5 (À5.5) À5.1 (À5.5) À5.5 (À5.6) À5.1 (À3.9) Chemically synthesized chloroquine derivatives 6. CQN2A ( derivatives can bind to Spike glycoprotein, which can potentially lead to disruption of Spike protein interaction with the ACE-2 on host cell surface. Furthermore, Chloroquine derivatives have been tested on Pneumocystis pneumonia (PcP) for their therapeutic activity to repurposing antimalarial drugs for Pneumonia (Gomes et al., 2018; Yeo et al., 2020) .
    keywords: binding; chloroquine; derivatives; docking; drug; hydroxychloroquine; potential; proteins; results; sars; site
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        item: #135 of 156
          id: cord-336420-1a2u9p4t
      author: Söderman, Martina
       title: Frequent Respiratory Viral Infections in Children with Febrile Neutropenia - A Prospective Follow-Up Study
        date: 2016-06-16
       words: 4204
      flesch: 41
     summary: Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america A prospective study on the epidemiology of febrile episodes during chemotherapy-induced neutropenia in children with cancer or after hemopoietic stem cell transplantation Respiratory viruses, a common microbiological finding in neutropenic children with fever Frequency and Clinical Outcome of Respiratory Viral Infections and Mixed Viral-bacterial Infections in Children With Cancer, Fever and Neutropenia Nasopharyngeal Detection of Respiratory Viruses in Febrile Neutropenic Children Health-related quality of life anticipated with different management strategies for paediatric febrile neutropaenia European guidelines for empirical antibacterial therapy for febrile neutropenic patients in the era of growing resistance: summary of the Antibiotic resistance is associated with longer bacteremic episodes and worse outcome in febrile neutropenic children with cancer Invasive fungal infections in paediatric acute myeloid leukaemia The Clinical Feature of Invasive Fungal Infection in Pediatric Patients With Hematologic and Malignant Diseases Community-acquired pneumonia requiring hospitalization among U.S. children Respiratory viral infections in children with leukemia Clinical utility of PCR for common viruses in acute respiratory illness Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values Upper respiratory virus detection without parent-reported illness in children is virus-specific Respiratory pathogens in children with and without respiratory symptoms Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in children Frequent and prolonged shedding of bocavirus in young children attending daycare Development and implementation of a molecular diagnostic platform for daily rapid detection of 15 respiratory viruses Coexistence of two clades of enterovirus D68 in pediatric Swedish patients in the summer and fall of 2014 Screening respiratory samples for detection of human rhinoviruses (HRVs) and enteroviruses: comprehensive VP4-VP2 typing reveals high incidence and genetic diversity of HRV species C New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0 Management of respiratory viral infections in hematopoietic cell transplant recipients and patients with hematologic malignancies Influenza A/H1N1 in pediatric oncology patients Pathogenesis of bloodstream infection in children with blood cancer A prospective study of septicaemia on a paediatric oncology unit: a three-year experience at The Royal Liverpool Children's Hospital, Alder Hey, UK Respiratory virus infection among hematopoietic cell transplant recipients: evidence for asymptomatic parainfluenza virus infection Human rhinovirus species associated with hospitalizations for acute respiratory illness in young US children Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia High prevalence of human rhinovirus C infection in Thai children with acute lower respiratory tract disease Human rhinovirus C infections in pediatric hematology and oncology patients Respiratory syncytial viral infection in children with compromised immune function Epidemiology of multiple respiratory viruses in childcare attendees Duration of rhinovirus shedding in the upper respiratory tract in the first year of life Clinical assessment and improved diagnosis of bocavirus-induced wheezing in children Human bocavirus in children with acute lymphoblastic leukemia Persistence of human bocavirus DNA in immunocompromised children Although respiratory viruses are commonly associated with this condition, the etiologic significance of this finding remains unclear and is therefore the subject of this study.
    keywords: children; episodes; neutropenia; respiratory; viruses
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        item: #136 of 156
          id: cord-337481-cxrjzva4
      author: Kang, Minghui
       title: A chromosome-scale genome assembly of Isatis indigotica, an important medicinal plant used in traditional Chinese medicine: An Isatis genome
        date: 2020-02-01
       words: 5021
      flesch: 35
     summary: We clustered the annotated genes into gene families among I. indigotica and eight other Brassicaceae species with Cleome hassleriana as the outgroup. A total of 24,382 I. indigotica genes (80.41%) clustered into 18,900 gene families, of which 10,826 (57.28%) gene families were shared with nine other species and 896 (4.74%) were I. indigotica specific ( Fig.
    keywords: assembly; biosynthesis; brassicaceae; candidate; chromosome; compounds; fig; genes; genome; indigotica; isatis; plant; species; table
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        item: #137 of 156
          id: cord-338487-jcueu1xh
      author: Rauch, Sheila A.M.
       title: Rising Tide: Responding to the Mental Health Impact of the COVID‐19 Pandemic
        date: 2020-05-18
       words: 1839
      flesch: 46
     summary: while assuring access to those in need of higher levels of mental health intervention are critically important goals. As basic principles across all phases and levels, systems and individuals engaging in mental health response are encouraged to: 1) Ensure basic needs for food, sleep, and lodging are met.
    keywords: health; pandemic; resources; response; support
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        item: #138 of 156
          id: cord-338750-6jfw49y7
      author: Albiol, Nil
       title: Autoimmune thrombotic thrombocytopenic purpura (TTP) associated with COVID-19
        date: 2020-05-28
       words: 656
      flesch: 40
     summary: We present a case of acquired autoimmune TTP whose onset occurred immediately after COVID-19, since the patient was admitted for this latter infection with normal laboratory values. key: cord-338750-6jfw49y7 authors: Albiol, Nil; Awol, Rahinatu; Martino, Rodrigo title: Autoimmune thrombotic thrombocytopenic purpura (TTP) associated with COVID-19 date: 2020-05-28 journal:
    keywords: covid-19; day; table
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        item: #139 of 156
          id: cord-339039-6gyo9rya
      author: Bonvehí, Pablo E.
       title: Transmission and Control of Respiratory Viral Infections in the Healthcare Setting
        date: 2018-04-30
       words: 4740
      flesch: 34
     summary: They point out the main characteristics of these viruses in immunosuppressed hosts such as prolonged excertion and higher morbidity and mortality in relation to normal hosts The influenza viruses and influenza Incidence and recall of influenza in a cohort of Glasgow healthcare workers during the 1993-4 epidemic: results of serum testing and questionnaire Adenovirus in solid organ transplant recipients Prolonged recovery of desiccated adenoviral serotypes 5, 8, and 19 from plastic and metal surfaces in vitro Potential role of hands in the spread of respiratory viral infections: studies with human parainfluenza virus 3 and rhinovirus 14 Infection Control of Nosocomial Respiratory Viral Disease in the Immunocompetent Host An outbreak of human parainfluenza virus 3 infection in an outpatient hematopoietic stem cell transplantation clinic Dare and Talbot make a very good description of health care acquired viral respiratory infections, their different control measures(education, hand-washing, isolation, PPE, cohorting of patients and personnel) and other measures such as influenza vaccination Parainfluenza virus infections in hematopoietic cell transplant recipients and hematologic malignancy patients: a systematic review Respiratory virus infection among hematopoietic cell transplant recipients: evidence for asymptomatic parainfluenza virus infection Viral respiratory tract infections in transplant patients: epidemiology, recognition and management How contagious are common respiratory tract infections? Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission An outbreak of respiratory syncytial virus in a bone marrow transplant center Detection and control of a nosocomial respiratory syncytial virus outbreak in a stem cell transplantation unit: the role of palivizumab Respiratory syncytial virus infection in adults Immunization of health-care personnel: recommendations of the Advisory Committee on Immunization Practices (ACIP) Influenza Vaccination of Healthcare Workers: Critical Analysis of the Evidence for Patient Benefit Underpinning Policies of Enforcement Safety and effectiveness of neuraminidase inhibitors for influenza treatment, prophylaxis, and outbreak control: a systematic review of systematic reviews and/or meta-analyses Oseltamivir and inhaled zanamivir as influenza prophylaxis in Thai heaith workers: a randomized, double-blind, placebo-controlled safety trial over 16 weeks Adenovirus type 8 epidemic keratoconjunctivitis in an eye clinic: risk factors and control Adenovirus: current epidemiology and emerging approaches to prevention and treatment Emerging viral respiratory tract infections-environmental risk factors and transmission Safety and immunogenicity of an intranasal Sendai virus-based human parainfluenza virus type 1 vaccine in 3-to 6-year-old children An opportunistic pathogen afforded ample opportunities: Middle East Respiratory Syndrome Coronavirus Viral respiratory infections have been recognized as a cause of severe illness in immunocompromised and non-immunocompromised hosts.
    keywords: contact; control; healthcare; infections; influenza; measures; patients; rsv; transmission; virus
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        item: #140 of 156
          id: cord-340125-il35gs97
      author: Jayapal, Manikandan
       title: Genome-wide gene expression profiling of human mast cells stimulated by IgE or FcεRI-aggregation reveals a complex network of genes involved in inflammatory responses
        date: 2006-08-16
       words: 7398
      flesch: 42
     summary: Mast cells in innate immunity Mast cells to the defense Mast cells in autoimmune disease Mast cells The diverse potential effector and immunoregulatory roles of mast cells in allergic disease Transcriptional response of human mast cells stimulated via the FcεRI and identification of mast cells as a source of IL-11 The receptor with high affinity for IgE Signalling through the high-affinity IgE receptor FcεRI Roles of mast cells and basophils in innate and acquired immunity Complexity and redundancy in the pathogenesis of asthma: reassessing the roles of mast cells and T cells Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice An essential role of mast cells in the development of airway hyperresponsiveness in a murine asthma model Mast cells phagocytosis of FimH expressing enterobacteria Histamine-induced activation of human lung macrophages key: cord-340125-il35gs97 authors: Jayapal, Manikandan; Tay, Hwee Kee; Reghunathan, Renji; Zhi, Liang; Chow, Kah Kiong; Rauff, Mary; Melendez, Alirio J title: Genome-wide gene expression profiling of human mast cells stimulated by IgE or FcεRI-aggregation reveals a complex network of genes involved in inflammatory responses date: 2006-08-16 journal: BMC Genomics DOI: 10.1186/1471-2164-7-210 sha: doc_id: 340125 cord_uid: il35gs97 BACKGROUND:
    keywords: activation; aggregation; anti; cells; cytokines; expression; fcεri; genes; ige; immune; mast; mast cells; responses; role; sensitization; table
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        item: #141 of 156
          id: cord-341063-3rqnu5bu
      author: None
       title: 38th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 20-23 March 2018
        date: 2018-03-29
       words: 98736
      flesch: 48
     summary: Since altered liver function has also been described in ICU patients without sepsis [1, 2] , the influence of sepsis may be overestimated. The aim of this work is to analyze the connection between serum and fecal levels of AMM in ICU patients.
    keywords: acute; admission; adult patients; age; aim; aki; analysis; ards; arrest; assessment; baseline; blood; brain; cardiac; care; care patients; care unit; cases; changes; clinical; cohort; complications; conclusions; control; correlation; criteria; critical; data; day mortality; days; decrease; diagnosis; difference; discharge; duration; dysfunction; early; effect; emergency; end; factors; failure; fig; flow; fluid; following; group; hospital; hospital mortality; hours; icu admission; icu mortality; icu patients; icu stay; impact; incidence; increase; infection; injury; introduction; length; levels; lung; mean; median; medical; methods; min; model; months; mortality; non; organ; outcome; p<0.001; parameters; patients; period; population; post; pressure; protocol; rate; renal; results; risk; risk patients; score; sepsis; septic; severity; shock; significant; sofa; stay; studies; study; support; surgery; surgery patients; survival; survivors; table; test; therapy; time; total; transfusion; treatment; unit; use; value; ventilation; volume; years
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        item: #142 of 156
          id: cord-342012-1w3x0g42
      author: Wu, Joseph T.
       title: Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China
        date: 2020-03-19
       words: 5333
      flesch: 48
     summary: Public health control measures widely imposed in China since the Wuhan alert have also kept case numbers down elsewhere, so that their health systems are not nearly as overwhelmed beyond surge capacity, thus again perhaps leading to better outcomes 6, 8 . Let G be the cumulative number of death cases in Wuhan as of 25 February 2020 (time T).
    keywords: age; cases; data; death; estimates; fatality; number; table; time; wuhan
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        item: #143 of 156
          id: cord-343090-dsjq98ks
      author: Fragkou, Paraskevi C.
       title: Review of trials currently testing treatment and prevention of COVID-19
        date: 2020-05-23
       words: 2032
      flesch: 36
     summary: As with treatment trials, many prevention trials do not 327 report the study phase (n=4, 25%). Most studies were randomised (n=10, 63%) with a parallel Figure 5 shows 341 the total number of planned inclusions and the number of clinical trials for the ten most 342 frequently studied treatments, with hydroxychloroquine being the treatment associated with A clinical primary outcome was defined in 128 out of 198 therapeutic trials (65% ; Table 3) .
    keywords: covid-19; prevention; studies; table; treatment; trials
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        item: #144 of 156
          id: cord-343963-99rd3o79
      author: Wong, Mun-Teng
       title: Emerging roles of interferon-stimulated genes in the innate immune response to hepatitis C virus infection
        date: 2014-12-29
       words: 17306
      flesch: 34
     summary: RIG-I-mediated type I interferon-dependent innate immunity Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase Phosphorylation of hepatitis C virus NS5A nonstructural protein: a new paradigm for phosphorylation-dependent viral RNA replication? Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture Hepatitis C virus NS5A: tales of a promiscuous protein Hepatitis C virus nonstructural protein 5A modulates the Toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein How hepatitis C virus counteracts the interferon response: the jury is still out on NS5A Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferoninduced antiviral response Relationships between hepatitis C virus replication and CXCL-8 production in vitro Hepatitis C virus NS5A protein interacts with 29,59-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner Activation and evasion of the antiviral 29-59 oligoadenylate synthetase/ribonuclease L pathway by hepatitis C virus mRNA Hepatitis C virus NS5A protein protects against TNF-alpha mediated apoptotic cell death Inhibition of intrahepatic gamma interferon production by hepatitis C virus nonstructural protein 5A in transgenic mice Hepatitis C virus nonstructural protein 5A inhibits tumor necrosis factor-a-mediated apoptosis in Huh7 cells Activation of endoplasmic reticulum stress response by hepatitis viruses upregulates protein phosphatase 2A Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling PP2A targeting by viral proteins: a widespread biological strategy from DNA/RNA tumor viruses to HIV-1 Hepatitis C virus inhibits interferon signaling through upregulation of protein phosphatase 2A Upregulation of protein phosphatase 2Ac by hepatitis C virus modulates NS3 helicase activity through inhibition of protein arginine methyltransferase 1 Transcriptional induction of two genes in human cells by b interferon Functional classification of interferon-stimulated genes identified using microarrays A central role for RNA in the induction and biological activities of type 1 interferons Targeted impairment of innate antiviral responses in the liver of chronic hepatitis C patients Negative feedback regulation of RIG-I-mediated antiviral signaling by interferoninduced ISG15 conjugation Immune signaling by RIG-I-like receptors Retinoic acid inducible gene-I (RIG-I) signaling of hepatic stellate cells inhibits hepatitis C virus replication in hepatocytes Interferon-b pretreatment of conventional and plasmacytoid human dendritic cells enhances their activation by influenza virus A structure-based model of RIG-I activation Emerging role of ubiquitination in antiviral RIG-I signaling DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling Hepatitis C virus induces interferon-and interferon-stimulated genes in primary liver cultures IRF family of transcription factors as regulators of host defense Regulation of PKR and IRF-1 during hepatitis C virus RNA replication Constitutive expression of an ISGF2/IRF1 transgene leads to interferon-independent activation of interferon-inducible genes and resistance to virus infection Regulation of hepatitis C virus replication by interferon regulatory factor 1 IRF-7 is the master regulator of type-I interferon-dependent immune responses Hepatitis C virus infection impairs IRF-7 translocation and Alpha interferon synthesis in immortalized human hepatocytes IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling Hepatitis C virus inhibits intracellular interferon alpha expression in human hepatic cell lines Serum-derived hepatitis C virus infectivity in interferon regulatory factor-7-suppressed human primary hepatocytes Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection Antiviral actions of interferons Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection PKR protein kinase is activated by hepatitis C virus and inhibits viral replication through translational control PKR-dependent mechanisms of gene expression from a subgenomic hepatitis C virus clone Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virus Alpha interferon induces distinct translational control programs to suppress hepatitis C virus RNA replication New antiviral pathway that mediates hepatitis C virus replicon interferon sensitivity through ADAR1 Hepatitis C virus controls interferon production through PKR activation Translational resistance of late alphavirus mRNA to eIF2a phosphorylation: a strategy to overcome the antiviral effect of protein kinase PKR Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability Translational insensitivity to potent activation of PKR by HCV IRES RNA HCV NS5A co-operates with PKR in modulating HCV IRES-dependent translation Eukaryotic translation initiation machinery can operate in a bacterial-like mode without eIF2 Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylation Hepatitis C virus (HCV) induces formation of stress granules whose proteins regulate HCV RNA replication and virus assembly and egress P bodies, stress granules, and viral life cycles Stress granules: sites of mRNA triage that regulate mRNA stability and translatability Stress granules Eukaryotic stress granules: the ins and outs of translation Regulation of stress granules and P-bodies during RNA virus infection Diversion of stress granules and P-bodies during viral infection Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection Hepatitis C virus hijacks P-body and stress granule components around lipid droplets Hepatitis C virus coopts Ras-GTPase-activating protein-binding protein 1 for its genome replication Viral encounters with 29,59-oligoadenylate synthetase and RNase L during the interferon antiviral response New insights into the role of RNase L in innate immunity The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities The ribonuclease Ldependent antiviral roles of human 29,59-oligoadenylate synthetase family members against hepatitis C virus 59-Oligoadenylate synthetaselike gene highly induced by hepatitis C virus infection in human liver is inhibitory to viral replication in vitro Antiviral activities of ISG20 in positive-strand RNA virus infections ISG20, an actor of the innate immune response Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral Adenosine deaminases acting on RNA, RNA editing, and interferon action RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR Expression of interferoninducible RNA adenosine deaminase ADAR1 during pathogen infection and mouse embryo development involves tissueselective promoter utilization and alternative splicing RNA editing of hepatitis delta virus antigenome by dsRNA-adenosine deaminase A specific base transition occurs on replicating hepatitis delta virus RNA RNA editing in hepatitis delta virus HCV-induced ER stress HCV protein expression can induce an ER stress response and lead to calcium release from the ER, which in turn activates the cyclic AMP responsive element-binding protein that binds to the cyclic AMP responsive element in the promoter of protein phosphatase 2A (PP2A), resulting in upregulation of PP2A. 114 Expressed in essentially all cell types, PP2A is a serine/threonine phosphatase that is involved in multiple cellular processes, such as the cell cycle, signal transduction and stress response.
    keywords: activation; activity; antiviral; autophagy; c virus; cells; expression; hcv; hepatitis; host; ifn; immunity; infection; innate; interferon; isgs; ns5a; pkr; production; protein; replication; response; rig; rna; signaling; type; virus; virus infection; virus replication; viruses
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        item: #145 of 156
          id: cord-344960-m1spgpyu
      author: Liu, Ying
       title: Roles of MicroRNA-122 in Cardiovascular Fibrosis and Related Diseases
        date: 2020-08-27
       words: 5050
      flesch: 29
     summary: Surprisingly, compared with those in mice in sham-operated and control groups, miR-122 levels were significantly increased in male C57BL/6 mice with atrial fibrillation, and this increase was significantly decreased by transfection with the miR-122 inhibitor [63] . Additionally, the miR-122 level is related to the severity of hypertension, atherosclerosis, atrial fibrillation, acute myocardial infarction and heart failure, and miR-122 expression is a risk factor for these diseases.
    keywords: apoptosis; dysfunction; fibrosis; fig; heart; hypertension; levels; mir-122; patients; remodeling
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        item: #146 of 156
          id: cord-345373-ulsz1d85
      author: Grabia, Monika
       title: The Nutritional and Health Effects of the COVID-19 Pandemic on Patients with Diabetes Mellitus
        date: 2020-09-30
       words: 6946
      flesch: 49
     summary: At the time the survey was conducted, stress levels were starting to return to pre-pandemic levels. Study results revealed several improvements in dietary habits of the youngest respondents during the pandemic (see Supplementary Table S10 ).
    keywords: consumption; covid-19; covid-19 pandemic; diabetes; meals; pandemic; respondents; study; table
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        item: #147 of 156
          id: cord-346245-o9hvuwvq
      author: Harvey, David J.
       title: Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2009–2010
        date: 2014-05-26
       words: 62921
      flesch: 24
     summary: A method for the quantification of fructo-oligosaccharides using MALDI TOF MS with DHB as the matrix, has been developed with the fructan, raftilose, a partially hydrolyzed inulin with a degree of polymeration 2-7 as the test compound (Onofrejová, Farková, & Preisler, 2009) . It was assumed that when the shockwave arrived at the sample surface it caused a second ablation of the neutral molecules (Hellwig et al., 2009) .
    keywords: acid; activity; addition; amino; analysis; antibodies; antibody; antigen; application; approach; binding; biosynthesis; cancer; carbohydrate; cell; chains; characterization; chca; chemical; chemistry; chromatography; click; complex; compounds; core; cyclodextrin; data; derivatives; desorption; detection; determination; development; dhb; effect; enrichment; enzymatic; enzyme; et al; expression; formation; fragmentation; fragments; gal; galactose; glcnac; glucose; glycan analysis; glycans; glycans tof; glycomics; glycopeptides; glycoproteins; glycosylation; group; human; hydrolysis; identification; igg; imaging; ionic; ionization; ionization mass; ions; laser; laser desorption; lectin; linear; linkage; lipid; liquid; loss; low; maldi; maldi analysis; maldi ion; maldi ms; maldi synthesis; maldi tof; mannose; mass spectrometry; matrices; matrix; method; mode; molecular; molecules; mouse; ms analysis; ms n; nanoparticles; new; non; novel; oligosaccharides; phase; plant; pngase; potential; preparation; presence; production; profiling; properties; reaction; release; residues; residues tof; results; review; sample; serum; sialic; sialylated; sites; specific; spectra; spectrometric; structure; studies; study; sugar; sulfate; surface; synthesis; system; technique; time; tissue; tof; tof analysis; tof mass; tof ms; tof synthesis; tof use; type; use; wall
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        item: #148 of 156
          id: cord-346265-jx4kspen
      author: Tatapudi, Hanisha
       title: Impact assessment of full and partial stay-at-home orders, face mask usage, and contact tracing: An agent-based simulation study of COVID-19 for an urban region
        date: 2020-10-19
       words: 5642
      flesch: 45
     summary: Simulation model tracks hourly movements of each individual (susceptible and infected) every day, and records for each susceptible the number of infected contacts and their identification at each location. Up to 14 days before the first reported case can be used as a potential date for simulation model to begin.
    keywords: cases; contact; covid-19; data; face; infection; model; pandemic; simulation; table
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        item: #149 of 156
          id: cord-350229-56rt4wga
      author: Pattnaik, Debidutta
       title: Trade credit research before and after the global financial crisis of 2008 – A bibliometric overview
        date: 2020-06-30
       words: 5221
      flesch: 42
     summary: key: cord-350229-56rt4wga authors: Pattnaik, Debidutta; Hassan, Mohammad Kabir; Kumar, Satish; Paul, Justin title: Trade credit research before and after the global financial crisis of 2008 – A bibliometric overview date: 2020-06-30 journal: nan DOI: 10.1016/j.ribaf.2020.101287 sha: doc_id: 350229 cord_uid: 56rt4wga Abstract This study presents an overview of the state-of-the-art in trade credit research by examining 1191 publications between 1955 and 2019.
    keywords: articles; citations; credit; number; publications; research; study; table; trade
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        item: #150 of 156
          id: cord-350286-n7ylgqfu
      author: Giri, Rajanish
       title: When Darkness Becomes a Ray of Light in the Dark Times: Understanding the COVID-19 via the Comparative Analysis of the Dark Proteomes of SARS-CoV-2, Human SARS and Bat SARS-Like Coronaviruses
        date: 2020-04-03
       words: 15857
      flesch: 51
     summary: Evaluation of intrinsic disorder in non-structural proteins of Bat CoV. Table 7 : Predicted MoRF residues in Human SARS proteins. Supplementary Table 10 : Predicted nucleotide-binding residues in Human SARS proteins.
    keywords: analysis; bat cov; binding; coronavirus; cov; cov-2; disorder; domain; figure; human; mean; protein; regions; residues; rna; sars; sars cov; sequence; structure; syndrome; table; terminal; viral; viruses
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        item: #151 of 156
          id: cord-350892-qz6ef05y
      author: Xu, Shanhui
       title: Yeast as a promising heterologous host for steroid bioproduction
        date: 2020-07-13
       words: 8334
      flesch: 33
     summary: The de novo synthesis of cholesterol in yeast was first reported in 2011 [60] , which is a milestone of yeast heterologous sterol synthesis and yeast steroid production has attracted much attention since then [61, 62, [64] The versatility of yeast ergosterol biosynthesis implicates the potential of yeast to synthesize diversified sterol structures through ergosterol biosynthesis engineering and heterologous pathway reconstitution.
    keywords: bioproduction; biosynthesis; biotransformation; campesterol; cerevisiae; cholesterol; conversion; engineering; enzymes; ergosterol; hydrocortisone; hydroxylation; membrane; production; steroid; sterols; strains; yeast
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        item: #152 of 156
          id: cord-352016-d2dvdzb1
      author: Zhang, Xiaoqian
       title: Marketization vs. market chase: Insights from implicit government guarantees
        date: 2020-06-27
       words: 7424
      flesch: 57
     summary: According to Amstad and He (2019) , government bonds is 57.55% in China which is lower than US (63.94%). Section 2 briefly reviews China bond market and regulations, and the implicit government guarantees implied in MCBs.
    keywords: bond; china; column; credit; gdp; government; guarantee; level; market; mcbs; table
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        item: #153 of 156
          id: cord-352080-3rcqbgl7
      author: Shidham, Vinod B.
       title: Severe acute respiratory syndrome coronavirus 2 (the cause of COVID 19) in different types of clinical specimens and implications for cytopathology specimen: An editorial review with recommendations
        date: 2020-04-10
       words: 3489
      flesch: 42
     summary: [18] e findings are comparable to those observed with SARS-CoV-1 [22] e effect of time and concentrations of various fixatives and biocidal agents on SARS and a few other viruses are summarized in Table 5 .
    keywords: coronavirus; cov-2; infectivity; log10; precautions; sars; specimen; table; virus
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        item: #154 of 156
          id: cord-352990-0uglwvid
      author: Nadim, Sk Shahid
       title: Occurrence of backward bifurcation and prediction of disease transmission with imperfect lockdown: A case study on COVID-19
        date: 2020-08-17
       words: 3272
      flesch: 50
     summary: It is observed that the system undergoes backward bifurcation which is a new observation for COVID-19 disease transmission model. We perform the sensitivity of model parameters with respect to the significant re-311 sponse variable and analyze different control parameters to limit COVID cases for the 312 four countries.
    keywords: lockdown; model; number; reproduction
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        item: #155 of 156
          id: cord-353965-0bb729sp
      author: Halim, Ashraf Abdel
       title: Clinical characteristics and outcome of ICU admitted MERS corona virus infected patients
        date: 2016-01-31
       words: 3655
      flesch: 42
     summary: Patients and methods This study included 32 laboratory confirmed MERS corona virus infected patients who were admitted into ICU. This study included 32 laboratory confirmed MERS corona virus patients who were admitted into ICU.
    keywords: mortality; patients; smoking; survivors
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        item: #156 of 156
          id: cord-354651-bxm9yxjm
      author: Zeng, Yawen
       title: Molecular Mechanism of Functional Ingredients in Barley to Combat Human Chronic Diseases
        date: 2020-03-30
       words: 16017
      flesch: 36
     summary: Interestingly, the types of prevention and treatment of human chronic diseases by key functional components in barley grain were in order: β-glucans (16)>polyphenols (13)>arabinoxylan (7) = tocols (7)>phytosterols (5)>resistant starch (4), but GABA (13)>flavonoids (11)>SOD (8)>K-Ca (7) = vitamins (7)>tryptophan (3) in barley grains. More than 30 functional ingredients in barley grass can combat over 20 chronic diseases, and 15 functional ingredients in barley grains may prevent 11 chronic diseases [9] .
    keywords: acid; activity; antioxidant; arabinoxylan; barley; barley grains; barley β; cells; cholesterol; content; diet; diseases; effects; extract; food; gaba; glucan; glucose; grains; grass; health; homo; hulless; hulless barley; human; ingredients; mg/100; phytosterols; polyphenols; role; sapiens; starch; total
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