# bib

id: cord-023855-3ta5lhnw
author: Decaro, Nicola
title: Alphacoronavirus(‡): Coronaviridae
date: 2011
extension: .txt
mime: text/plain
words: 206
sentence: 12
flesch: 44
cache: cache/cord-023855-3ta5lhnw.txt
txt: txt/cord-023855-3ta5lhnw.txt
summary:
  Recombinant TGEV shows that S protein determines enteropathogenicity and virulence Sanchez et al (1999) 1975 ICTV approves Coronaviridae family with one genus, Coronavirus Tyrrell et al (1975 Tyrrell et al ( ) 1980 Demonstration that antibodies to feline enteric coronavirus enhance feline infectious peritonitis Pedersen and Boyle (1980) 1989 Alternative model for transcription (TGEV): discontinuous transcription during


id: cord-004729-nmkilkcx
author: Reynolds, D. J.
date: 1979
extension: .txt
mime: text/plain
words: 2000
sentence: 81
flesch: 44
cache: cache/cord-004729-nmkilkcx.txt
txt: txt/cord-004729-nmkilkcx.txt
title:
  Virus isolation and serum antibody responses after infection of cats with transmissible gastroenteritis virus

summary:
  The medium was changed after 24 hours and 4 days later any viral eytopathic effect was recorded, the medium was removed and passaged in fresh APT/2 cultures and the eoverslips were stained to demonstrate virM antigen by indirect immunofluorescence, using paired sera from a gnotobiotic piglet before and after TGEV infection, followed by FITCconjugated rabbit anti-swine globulin (Nordic Immunological Laboratories, London). This evidence has been used to suggest that an antigenic relationship exists between TGEV and F I P virus.


id: cord-265224-mwgccr4a
author: Delmas, Bernard
title: Aminopeptidase N is a major receptor for the enteropathogenic coronavirus TGEV
date: 1992
extension: .txt
mime: text/plain
words: 2110
sentence: 81
flesch: 43
cache: cache/cord-265224-mwgccr4a.txt
txt: txt/cord-265224-mwgccr4a.txt
summary:
  Aminopeptidase N is a major receptor for the enteropathogenic coronavirus TGEV date: 1992 journal: Nature DOI: 10.1038/357417a0 sha: doc_id: 265224 cord_uid: mwgccr4a CORONAVIRUSES, like many animal viruses, are characterized by a restricted host range and tissue tropism(1). Aminopeptidase N is a major receptor for the enteropathogenic coronavirus TGEV acts as a receptor.


id: cord-257974-kllqjn68
author: Woods, Roger D.
date: 1988
extension: .txt
mime: text/plain
words: 2335
sentence: 86
flesch: 44
cache: cache/cord-257974-kllqjn68.txt
txt: txt/cord-257974-kllqjn68.txt
title:
  Cultivation techniques for animal coronaviruses: Emphasis on feline infectious peritonitis virus, canine coronavirus, transmissible gastroenteritis virus, and porcine hemagglutinating encephalomyelitis virus

summary:
  The complete nucleotide sequence of the three major structural proteins of TGEV has been determined on cDNA clones of attenuated virus grown in ST cell culture (15,17,18,32L 9O Isolation of transmissible enteritis agent of turkeys in avian embryos Propagation of hemagglutinating encephalomyelitis virus in porcine cell culture. Basic studies on these viruses have been limited because of their fastidious growth in cell culture (14) .


id: cord-018865-melttpiq
author: Yu, Tian-fei
date: 2012
extension: .txt
mime: text/plain
words: 2194
sentence: 88
flesch: 46
cache: cache/cord-018865-melttpiq.txt
txt: txt/cord-018865-melttpiq.txt
title:
  Express Transmissible Gastroenteritis Virus Spike Gene B and C Antigen Sites in Multiple Expression Systems

summary:
  Although site B is conformation dependent, MAbs specific for this site can bind TGEV spike protein by immunoblotting providing that the samples were not treated with 2-mercaptoethanol. It is recognized by MAbs in Western blot analysis after treatment of the virus with 2.5% SDS and 5% 2-mercaptoethanol; It is represented by synthetic nonapeptides derived from TGEV spike protein [9] ; It is present in recombinant products expressed in bacteria, which do not reconstitute the native spike protein [10] ; and it is formed in the absence of glycosylation [8] .


id: cord-263489-i4tkdgy4
author: Suo, Siqingaowa
date: 2015-05-27
extension: .txt
mime: text/plain
words: 2222
sentence: 107
flesch: 61
cache: cache/cord-263489-i4tkdgy4.txt
txt: txt/cord-263489-i4tkdgy4.txt
title:
  Phage display for identifying peptides that bind the spike protein of transmissible gastroenteritis virus and possess diagnostic potential

summary:
  Herein, we use similar technology and advance previous work by using the rS-AD as an immobilizing target to select phages from a peptide display library, with diagnostic potential for TGEV. key: cord-263489-i4tkdgy4 authors: Suo, Siqingaowa; Wang, Xue; Zarlenga, Dante; Bu, Ri-e; Ren, Yudong; Ren, Xiaofeng title: Phage display for identifying peptides that bind the spike protein of transmissible gastroenteritis virus and possess diagnostic potential date: 2015-05-27 journal: Virus Genes DOI: 10.1007/s11262-015-1208-7 sha: doc_id: 263489 cord_uid: i4tkdgy4 The spike (S) protein of porcine transmissible gastroenteritis virus (TGEV) is located within the viral envelope and is the only structural protein that possesses epitopes capable of inducing virus-neutralizing antibodies.


id: cord-255653-0bj5eh5d
author: Pensaert, M. B.
date: 1981
extension: .txt
mime: text/plain
words: 2522
sentence: 127
flesch: 47
cache: cache/cord-255653-0bj5eh5d.txt
txt: txt/cord-255653-0bj5eh5d.txt
title:
  An immunoelectron microscopic and immunofluorescent study on the antigenic relationship between the coronavirus-like agent, CV 777, and several coronaviruses

summary:
  CVLA did not show cross reactivity with infectious bronchitis virus, transmissible gastroenteritis virus (TGEV), canine coronavirus (CCV) hemagglutinating encephalomyelitis virus (HEV), neonatal calf diarrhea coronavirus (NCDCV) or feline infectious peritonitis virus (FIPV). The CVLA was shown by serologic cross protection studies to differ from the two knowm porcine coronaviruses, transmissible gastroenteritis virus (TGEV) and hemagglntinating encephalomyelitis virus (HEV) (4, 14) .


id: cord-280183-fxhkfjl6
author: Have, P.
date: 1992-04-30
extension: .txt
mime: text/plain
words: 2688
sentence: 113
flesch: 51
cache: cache/cord-280183-fxhkfjl6.txt
txt: txt/cord-280183-fxhkfjl6.txt
title:
  Coronavirus infection in mink (Mustela vision). Serological evidence of infection with a coronavirus related to transmissible gastroenteritis virus and porcine epidemic diarrhea virus

summary:
  fxhkfjl6 Abstract Antibodies to a transmissible gastroenteritis virus (TGEV)-related coronavirus have been demonstrated in mink sera by indirect immunofluorescence, peroxidase-linked antibody assays and immunoblotting. Four groups of mink sera were selected for evaluation of MCV antibodies: A, 71 mink sera were obtained during 1990 from the Danish Fur Breeders Association as part of routine sampling for plasmacytosis testing (Aleutian disease, ADV).


id: cord-273712-r2akpce8
author: Wang, Jingjing
date: 2016-02-19
extension: .txt
mime: text/plain
words: 2590
sentence: 112
flesch: 49
cache: cache/cord-273712-r2akpce8.txt
txt: txt/cord-273712-r2akpce8.txt
title:
  Comparison of lentiviruses pseudotyped with S proteins from coronaviruses and cell tropisms of porcine coronaviruses

summary:
  Infection of lentiviruses pseudotyped shows that S proteins from different CoVs have varied abilities to mediate pseudotyped virus infection in different cell types from different tissues. key: cord-273712-r2akpce8 authors: Wang, Jingjing; Deng, Feng; Ye, Gang; Dong, Wanyu; Zheng, Anjun; He, Qigai; Peng, Guiqing title: Comparison of lentiviruses pseudotyped with S proteins from coronaviruses and cell tropisms of porcine coronaviruses date: 2016-02-19 journal:


id: cord-014697-aea67d8f
author: Escribano, J.M.
title: Immunogenicity of a recombinant coronavirus spike glycoprotein expressed in transgenic plants
date: 2000
extension: .txt
mime: text/plain
words: 2805
sentence: 99
flesch: 32
cache: cache/cord-014697-aea67d8f.txt
txt: txt/cord-014697-aea67d8f.txt
summary:
  Here we review data we obtained on the immunological response elicited by two recombinant versions of the glycoprotein S from the swine transmissible gastroenteritis coronavirus (TGEV) expressed in transgenic plants. From the above results, we conclude that transgenic plants expressing glycoprotein S polypeptides may be potentially used as a source of recombinant antigen for vaccine production.


id: cord-260208-fvdq0yes
author: Wang, Jinfeng
date: 2018-03-14
extension: .txt
mime: text/plain
words: 2707
sentence: 85
flesch: 44
cache: cache/cord-260208-fvdq0yes.txt
txt: txt/cord-260208-fvdq0yes.txt
title:
  Rapid detection of transmissible gastroenteritis virus in swine small intestine samples using real-time reverse transcription recombinase polymerase amplification

summary:
  Recently, RT-LAMP assays have been developed for TGEV detection (Chen et al., 2010; Li and Ren, 2011) . It is especially important for TGEV detection in under-equipped laboratories and in the field.


id: cord-007461-v3tff2gk
author: Nguyen, T.D.
date: 2002-11-12
extension: .txt
mime: text/plain
words: 2921
sentence: 116
flesch: 52
cache: cache/cord-007461-v3tff2gk.txt
txt: txt/cord-007461-v3tff2gk.txt
title:
  Transmissible gastroenteritis (TGE) of swine: In vitro virus attachment and effects of polyanions and polycations

summary:
  The effect of polycations and polyanions on virus attachment was also examined. Differences in susceptibility to TGEV infection, indicated by plaque formation, between the ST and RPD cells and effects of temperature on virus attachment were studied by incubating virus inoculum with the cells for 30 min at either 4 or 37°C.


id: cord-263025-mmdeyph3
author: Paton, D. J.
date: 1990
extension: .txt
mime: text/plain
words: 3024
sentence: 139
flesch: 57
cache: cache/cord-263025-mmdeyph3.txt
txt: txt/cord-263025-mmdeyph3.txt
title:
  Sows infected in pregnancy with porcine respiratory coronavirus show no evidence of protecting their sucking piglets against transmissible gastroenteritis

summary:
  The three litters born to TGEV inoculated sows which had seroconverted had lower values than any of the six litters born to uninoculated sows or any of the seven litters born to PRCV inoculated sows in respect of proportion of piglets scouring, percentage piglet diarrhoea days and average worst clinical score. An attempt was also made to quantify the duration of diarrhoea for each litter by calculating the percentage of piglet days on which diarrhoea was observed from 0 to 10 days post-challenge (percentage piglet diarrhoea days).


id: cord-001591-4ic2in3i
author: Hu, Xiaoliang
date: 2015-03-21
extension: .txt
mime: text/plain
words: 2899
sentence: 117
flesch: 53
cache: cache/cord-001591-4ic2in3i.txt
txt: txt/cord-001591-4ic2in3i.txt
title:
  Molecular characterization and phylogenetic analysis of transmissible gastroenteritis virus HX strain isolated from China

summary:
  Phylogenetic analysis of the complete S gene showed that TGEV strains could be divided into two groups ( Figure 3) . By comparing the S gene and protein with those of other TGEV strains, we have gained a further understanding of the genetic structure, diversity, and evolution of the TGEV-HX strain.


id: cord-015742-nt44jcjm
author: Garwes, D.J.
title: Antigenicity of structural components from porcine transmissible gastroenteritis virus
date: 2002-11-13
extension: .txt
mime: text/plain
words: 3605
sentence: 133
flesch: 37
cache: cache/cord-015742-nt44jcjm.txt
txt: txt/cord-015742-nt44jcjm.txt
summary:
  Neutralising antibody was demonstrated in serum and colostrum from animals that received whole virus or preparations of surface projections whereas subviral particles failed to stimulate neutralising antibody formation. In contrast, infection of sows with live whole virus resulted in neutralising antibody of the IgG, IgM and IgA classes.


id: cord-275635-d50bxe7c
author: Yuan, Xiaomin
date: 2015-07-31
extension: .txt
mime: text/plain
words: 3999
sentence: 164
flesch: 49
cache: cache/cord-275635-d50bxe7c.txt
txt: txt/cord-275635-d50bxe7c.txt
title:
  Efficacy and immunogenicity of recombinant swinepox virus expressing the A epitope of the TGEV S protein

summary:
  Domains in the peplomer glycoprotein Bacterial expression of antigenic sites A and D in the spike protein of transmissible gastroenteritis virus and evaluation of their inhibitory effects on viral infection Evaluation on the efficacy and immunogenicity of recombinant DNA plasmids expressing spike genes from porcine transmissible gastroenteritis virus and porcine epidemic diarrhea virus Construction, safety and immunogenicity analysis of attenuated Salmonella typhimurium harbouring TGEV DNA vaccine Localization of antigenic sites of the E2 glycoprotein of transmissible gastroenteritis coronavirus Expression of swine transmissible gastroenteritis virus envelope antigens on the surface of infected cells: epitopes externally exposed Clinical evaluation of transmissible gastroenteritis virus vaccines and vaccination procedures for inducing lactogenic immunity in sows A monoclonal antibody against transmissible gastroenteritis virus generated via immunization of a DNA plasmid bearing TGEV S1 gene 25 years and counting: Centers for Disease Control and Prevention identifies opportunities and challenges for diabetes prevention and control Development of a recombinant vaccinia-rabies vaccine for oral vaccination of foxes against rabies Recombinant fowlpox virus inducing protective immunity in non-avian species Recombinant swinepox virus expressing betagalactosidase: investigation of viral host range and gene expression levels in cell culture Construction of recombinant swinepox viruses and expression of the classical swine fever virus E2 protein Replication and expression of a swinepox virus vector delivering feline leukemia virus Gag and Env to cell lines of swine and feline origin Feline B7.1 and B7.2 proteins produced from swinepox virus vectors are natively processed and biologically active: potential for use as nonchemical adjuvants First insights into the protective effects of a recombinant swinepox virus expressing truncated MRP of Streptococcus suis type 2 in mice Immune responses and protection efficacy of a recombinant swinepox virus expressing HA1 against swine H3N2 influenza virus in mice and pigs A novel vaccine against Streptococcus equi ssp. key: cord-275635-d50bxe7c authors: Yuan, Xiaomin; Lin, Huixing; Fan, Hongjie title: Efficacy and immunogenicity of recombinant swinepox virus expressing the A epitope of the TGEV S protein date: 2015-07-31 journal: Vaccine DOI: 10.1016/j.vaccine.2015.06.057 sha: doc_id: 275635 cord_uid: d50bxe7c


id: cord-271815-yr1dq258
author: Hulkower, Rachel L.
title: Inactivation of surrogate coronaviruses on hard surfaces by health care germicides
date: 2011-06-30
extension: .txt
mime: text/plain
words: 4205
sentence: 175
flesch: 42
cache: cache/cord-271815-yr1dq258.txt
txt: txt/cord-271815-yr1dq258.txt
summary:
  These findings are consistent with previous studies of coronavirus disinfection, but this study provides more precise estimates of inactivation on surfaces than have been previously observed with other human coronaviruses, such as 229E. Some previous studies of chemical disinfection of 229E have been limited by cytotoxicity problems that limited the ability to measure infectious virus reduction. 7 Data from surrogate coronaviruses suggest that these viruses can survive for long periods on hard surfaces, potentially posing a continued risk of infection if health care surfaces are not adequately disinfected.


id: cord-255238-adpn5fb9
author: Pan, Yongfei
title: Discovery of a novel swine enteric alphacoronavirus (SeACoV) in southern China
date: 2017-09-28
extension: .txt
mime: text/plain
words: 4524
sentence: 159
flesch: 47
cache: cache/cord-255238-adpn5fb9.txt
txt: txt/cord-255238-adpn5fb9.txt
summary:
  Structure homology-modeling of SeACoV S glycoprotein was performed by the SWISS-MODEL server (https://www.swissmodel.expasy.org/). The entire SeACoV S protein had 86.4% aa identical with S of the HKU2/GD430 strain, but there was only a 67.4% identity in the extreme NTD of the S protein (S-NTD) between SeACoV and HKU2.


id: cord-260843-c97kctjz
author: Dai, Lei
date: 2016-11-16
extension: .txt
mime: text/plain
words: 4651
sentence: 192
flesch: 40
cache: cache/cord-260843-c97kctjz.txt
txt: txt/cord-260843-c97kctjz.txt
title:
  Transmissible Gastroenteritis Virus Infection Enhances SGLT1 and GLUT2 Expression to Increase Glucose Uptake

summary:
  EGFR has been reported to increased glucose uptake which is critical for the cell [10] , we found the EGFR and p-EGFR both promote glucose uptake in IPEC-J2 cells during TGEV infection. In this study, we therefore sought to evaluate the effects of TGEV infection on glucose uptake and SGLT1 and GLUT2 expression.


id: cord-018078-clxzp1ph
author: Weber, Olaf
title: Coronavirus infections in veterinary medicine
date: 2005
extension: .txt
mime: text/plain
words: 4436
sentence: 226
flesch: 39
cache: cache/cord-018078-clxzp1ph.txt
txt: txt/cord-018078-clxzp1ph.txt
summary:
  As for other coronavirus infections, only a virological examination, mainly based on serological techniques, can lead to the appropriate diagnosis. key: cord-018078-clxzp1ph authors: Weber, Olaf; Schmidt, Axel title: Coronavirus infections in veterinary medicine date: 2005 journal: Coronaviruses with Special Emphasis on First Insights Concerning SARS DOI: 10.1007/3-7643-7339-3_2 sha: doc_id: 18078 cord_uid: clxzp1ph nan tion is high frequency RNA recombination [4] .


id: cord-004755-rmnjs1t6
author: Welch, Siao-Kun Wan
date: 1988
extension: .txt
mime: text/plain
words: 4988
sentence: 228
flesch: 52
cache: cache/cord-004755-rmnjs1t6.txt
txt: txt/cord-004755-rmnjs1t6.txt
title:
  Monoclonal antibodies to a virulent strain of transmissible gastroenteritis virus: comparison of reactivity with virulent and attenuated virus

summary:
  [22] reported that their E 1-specific TGEV MAbs had VN activity only in the presence of 2 to 8 hemolytic units/ml of swine complement. Biochemical and biophysical differences among field isolates and cell cultureattenuated TGEV have been reported [4, 7] , but serologic differences were not identified [13, 14] .


id: cord-001843-ceatyj3o
author: Huang, Yong
title: Ultrasensitive Detection of RNA and DNA Viruses Simultaneously Using Duplex UNDP-PCR Assay
date: 2015-11-06
extension: .txt
mime: text/plain
words: 5196
sentence: 185
flesch: 45
cache: cache/cord-001843-ceatyj3o.txt
txt: txt/cord-001843-ceatyj3o.txt
summary:
  The sensitivity, specificity, and reproducibility of the UNDP-PCR assay for TGEV TGEV genomic RNA was extracted using RNA Kit and reverse transcribed to synthesize cDNA. Therefore, a UNDP-PCR method for RNA virus TGEV needs to be established first.


id: cord-263165-bv4dh9eu
author: Möstl, Karin
title: Coronaviridae, pathogenetic and clinical aspects: An update
date: 1990-12-31
extension: .txt
mime: text/plain
words: 4907
sentence: 287
flesch: 43
cache: cache/cord-263165-bv4dh9eu.txt
txt: txt/cord-263165-bv4dh9eu.txt
summary:
  Special attention is paid to coronavirus infections of domestic cattle and pets, whereas avian, murine, rat and human coronaviruses are summarized briefly. ges Characterization of the virus of Sialodacryoadenitis of rats: a member of the coronavirus group An apparently new respiratory disease of baby chicks Electron microscopy of coronavirus-like particles characteristic of turkey bluecomb disease Seroepidemiologic studies of coronavirus infection in adults and children Coronavirus particles in faeces from patients with gastroenteritis Enteric coronaviruses in primates Coronavirus and gastroenteritis in foals Isolation of coronavirus-like agent from horses suffering from acute equine diarrhoea syndrome


id: cord-002177-yyfgl9x5
author: Guo, Jinyue
title: TGEV infection up-regulates FcRn expression via activation of NF-κB signaling
date: 2016-08-24
extension: .txt
mime: text/plain
words: 5229
sentence: 211
flesch: 44
cache: cache/cord-002177-yyfgl9x5.txt
txt: txt/cord-002177-yyfgl9x5.txt
summary:
  Our studies showed that pFcRn expression can be triggered by TGEV infection, through NF-κ B signal activation. Furthermore, pFcRn expression induced by TGEV infection was strongly reduced by the NF-κ B-specific inhibitor BAY 11-7082 in IPEC-J2 cells (Fig. 3) .


id: cord-016178-2ix6c0he
author: Rajan, V.
title: An Oral Vaccine for TGEV Immunization of Pigs
date: 2014-05-28
extension: .txt
mime: text/plain
words: 6058
sentence: 216
flesch: 39
cache: cache/cord-016178-2ix6c0he.txt
txt: txt/cord-016178-2ix6c0he.txt
summary:
  Is the bronchus-associated lymphoid tissue (BALT) an integral structure of the lung in normal mammals, including humans? Antigenic modules in the N-terminal S1 region of the transmissible gastroenteritis virus spike protein Porcine coronaviruses Challenges in therapeutic glycoprotein production A continuous epitope from transmissible gastroenteritis virus S protein fused to E. coli heat-labile toxin B subunit expressed by attenuated Salmonella induces serum and secretory immunity Plant-based vaccines: unique advantages Expression, characterization, and biologic activity of recombinant human lactoferrin in rice Immunogenicity of the S protein of transmissible gastroenteritis virus expressed in baculovirus Immunogenicity of porcine transmissible gastroenteritis virus spike protein expressed in plants Development of oral vaccine in plants against transmissible gastroenteritis virus of swine Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice Oral tolerance: immune mechanisms and treatment of autoimmune diseases Oral tolerance A cysteine protease from maize isolated in a complex with cystatin Pregnant gilts received the following treatments: group A (oral corn vaccine on days À35 to À29 and À14 to À8), group B (oral corn vaccine on days À35 to À33 and À14 to À12), group C (oral corn vaccine on days À35 and À14), group D (oral corn placebo on days À14 to À8), group E (intramuscular live vaccine on days À35 and À14), and group F (oral corn vaccine on days À14 to À8), where the À sign represents days before farrowing.


id: cord-265312-yfjme53q
author: Magtoto, Ronaldo
date: 2019-03-13
extension: .txt
mime: text/plain
words: 6127
sentence: 209
flesch: 38
cache: cache/cord-265312-yfjme53q.txt
txt: txt/cord-265312-yfjme53q.txt
title:
  Evaluation of the Serologic Cross-Reactivity between Transmissible Gastroenteritis Coronavirus and Porcine Respiratory Coronavirus Using Commercial Blocking Enzyme-Linked Immunosorbent Assay Kits

summary:
  Moreover, the detection of TGEV antibodies, particularly in reproductive animals, can assist in diagnosis and control of the disease. Specimens primarily used for TGEV virus detection include feces and intestinal contents, and those for PRCV detection include nasal swabs or lung homogenates.


id: cord-253041-ts2aiykg
author: Ding, Li
date: 2014-03-07
extension: .txt
mime: text/plain
words: 3632
sentence: 146
flesch: 45
cache: cache/cord-253041-ts2aiykg.txt
txt: txt/cord-253041-ts2aiykg.txt
title:
  TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling

summary:
  However, whether TGEV N protein could affect cell division and cell apoptosis and the associated molecular mechanisms are not clear. In this study, we have investigated the effects of TGEV N protein on cell growth, cell cycle progression and cell apoptosis, as well as the mechanism that TGEV N protein causes the cell cycle arrest and apoptosis.


id: cord-010045-eqzs01au
author: Britton, P.
date: 2006-10-27
extension: .txt
mime: text/plain
words: 6194
sentence: 240
flesch: 49
cache: cache/cord-010045-eqzs01au.txt
txt: txt/cord-010045-eqzs01au.txt
title:
  Sequence of the nucleoprotein gene from a virulent British field isolate of transmissible gastroenteritis virus and its expression in Saccharomyces cerevisiae

summary:
  The nucleoprotein gene was expressed in yeast cells under the control of two types of yeast promoters: the constitutive PGK promoter, and the inducible GAL1 promoter. Yeast cells containing recombinant plasmids, with the nucleoprotein gene in the correct orientation, produced a polypeptide of M, 47000, identical to the viral product, that reacted with a specific monoclonal antibody.


id: cord-257116-6td3efjw
author: Zhou, Yanrong
date: 2017-08-09
extension: .txt
mime: text/plain
words: 5540
sentence: 195
flesch: 39
cache: cache/cord-257116-6td3efjw.txt
txt: txt/cord-257116-6td3efjw.txt
title:
  Cellular RNA Helicase DDX1 Is Involved in Transmissible Gastroenteritis Virus nsp14-Induced Interferon-Beta Production

summary:
  For each immunoprecipitation, 500 µg of cell lysate protein was incubated with 2 µg of indicated antibody and 25 µl of protein A/G-agarose (Beyotime) overnight at 4°C. MAb against TGEV N protein was prepared by our laboratory.


id: cord-003976-05tf6oqa
author: Wang, Kai
date: 2019-11-06
extension: .txt
mime: text/plain
words: 6977
sentence: 228
flesch: 47
cache: cache/cord-003976-05tf6oqa.txt
txt: txt/cord-003976-05tf6oqa.txt
title:
  Anti-TGEV Miller Strain Infection Effect of Lactobacillus plantarum Supernatant Based on the JAK-STAT1 Signaling Pathway

summary:
  The results in Figure 6 show that the amount of p-STAT1 (red fluorescence) in the nuclei of TGEV infected cells treated with Lp-1s at different time points was significantly higher than that in the nuclei of cells in TGEV infected group. As expected, the protein levels of ZAP, PKR, p-PKR (Figures 8A-D) at 24, and 48 hpi in the Lp-1s group were significantly higher than those in negative control group and TGEV group (ZAP, * P < 0.05 and PKR, *


id: cord-285812-l7dpv6nx
author: O’TOOLE, D.
title: Pathogenicity of experimental infection with ‘pneumotropic’ porcine coronavirus
date: 1989-07-31
extension: .txt
mime: text/plain
words: 3074
sentence: 139
flesch: 42
cache: cache/cord-285812-l7dpv6nx.txt
txt: txt/cord-285812-l7dpv6nx.txt
summary:
  The uninoculated, control piglets remained seronegative throughout the study period. Owing to its similarity to TGEV, the changes In r-ev-infected piglets were compared with those in piglets foIlowing TGEV infection.


id: cord-002019-wtnf340p
author: Chen, Xiaojuan
date: 2016-04-15
extension: .txt
mime: text/plain
words: 7249
sentence: 259
flesch: 42
cache: cache/cord-002019-wtnf340p.txt
txt: txt/cord-002019-wtnf340p.txt
title:
  Retinoic acid facilitates inactivated transmissible gastroenteritis virus induction of CD8(+) T-cell migration to the porcine gut

summary:
  To better understand whether RA could directly imprint gut-homing-specific receptors on porcine T cells, unactivated T cells were directly treated with or without RA in vitro, and then the homing receptors β 7 integrin and CCR9 were detected with flow cytometry. To determine whether RA in the vaccine could recruit DCs to the small intestine, we isolated intestinal cells from piglets and determined the DC numbers in the lamina propria by flow cytometry.


id: cord-254735-8reu45yz
author: Reguera, Juan
date: 2012-08-02
extension: .txt
mime: text/plain
words: 8111
sentence: 336
flesch: 54
cache: cache/cord-254735-8reu45yz.txt
txt: txt/cord-254735-8reu45yz.txt
title:
  Structural Bases of Coronavirus Attachment to Host Aminopeptidase N and Its Inhibition by Neutralizing Antibodies

summary:
  To confirm the contribution of the PRCV or TGEV RBD bbarrel tip in pAPN receptor recognition, we analyzed binding of wild type and mutant TGEV RBD proteins to cell surfaceexpressed pAPN ( Figure 4A ). pAPN protein was run through a Superdex 200 16/60 column (GE Healthcare) with HEPESsaline buffer pH 7.5.


id: cord-007491-yxz69nil
author: Weingartl, H.M.
date: 2002-11-13
extension: .txt
mime: text/plain
words: 3250
sentence: 104
flesch: 43
cache: cache/cord-007491-yxz69nil.txt
txt: txt/cord-007491-yxz69nil.txt
title:
  Binding of porcine transmissible gastroenteritis virus by enterocytes from newborn and weaned piglets

summary:
  Aminopeptidase N is a major receptor for the enteropathogenic coronavirus TGEV Studies of transmissible gastroenteritis virus receptors on swine testicle cells Plasma membranes from rat intestinal epithelial cells at different stages of maturation I. Preparation and characterization of plasma membrane subfractions originating from crypt cells and from villous cells Studies on transmissible gastroenteritis of swine II. Extent and dynamics of the epithelial response to virus invasion in transmissible gastroenteritis of piglets Interaction of viruses with cell surface receptors Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses Electron microscopy of intestinal epithelial cells of piglets infected with a transmissible gastroenteritis virus Intestinal epithelial cell surface membrane glycoprotein synthesis I.


id: cord-295967-mmgb7cxo
author: To, L. T.
date: 1992-12-31
extension: .txt
mime: text/plain
words: 3340
sentence: 105
flesch: 40
cache: cache/cord-295967-mmgb7cxo.txt
txt: txt/cord-295967-mmgb7cxo.txt
title:
  Transmissible gastroenteritis coronavirus: surface antigens induced by virulent and attenuated strains

summary:
  With this approach, we tried to find markers which would enable the differentiation of HP attenuated strains and LP virulent strains with regard to antigen expression on infected cell surface. For all 3 mutant viruses used, surface virus antigen quantity was significantly lower with the RP.D cells than with the ST cells.


id: cord-309433-wm0k13qh
author: Paton, D. J.
date: 1991-08-31
extension: .txt
mime: text/plain
words: 1038
sentence: 41
flesch: 49
cache: cache/cord-309433-wm0k13qh.txt
txt: txt/cord-309433-wm0k13qh.txt
title:
  An ELISA for the detection of serum antibodies to both transmissible gastroenteritis virus and porcine respiratory coronavirus

summary:
  ELISA antigens prepared by detergent treatment (octyl-b D-glucopyranoside : Aldrich) of LLCPKI cells, infected with the Purdue strain of TGEV or mock-infected, were coated onto alternate wells of flexible polystyrene ELISA plates (Falcon) with 0 Despite the good qualitative agreement between ELISA and VNT, no significant correlation was detected (coefficient=0 .072) between ELISA values and VNT titres for positive sera .


id: cord-269867-k10siwur
author: Méchin, Marie-Claire
date: 1996-12-31
extension: .txt
mime: text/plain
words: 4162
sentence: 121
flesch: 42
cache: cache/cord-269867-k10siwur.txt
txt: txt/cord-269867-k10siwur.txt
title:
  The major subunit ClpG of Escherichia coli CS31A fibrillae as an expression vector for different combinations of two TGEV coronavirus epitopes

summary:
  The ClpG exposure vector system described here provides a number of insertion sites and therefore a variety of flanking aa sequences for the expression of TGEV epitopes. Twelve sites within ClpG were selected for insertion of TGEV peptides (Fig. 1) .


id: cord-287590-jjft3den
author: Rodák, L.
date: 2005-05-05
extension: .txt
mime: text/plain
words: 3719
sentence: 153
flesch: 44
cache: cache/cord-287590-jjft3den.txt
txt: txt/cord-287590-jjft3den.txt
title:
  Use of Monoclonal Antibodies in Blocking ELISA Detection of Transmissible Gastroenteritis Virus in Faeces of Piglets

summary:
  Indirect ELISA TGEV antibodies in tested sera, in culture media of hybridomas and in purified mAbTGEV preparations were assayed using the indirect ELISA method. The relationship between incidence of TGEV gastroenteritis and the spread of porcine respiratory coronavirus infection in pig farms is discussed.


id: cord-287266-sd5izamc
author: Song, Zhenhui
date: 2019-04-30
extension: .txt
mime: text/plain
words: 4419
sentence: 173
flesch: 47
cache: cache/cord-287266-sd5izamc.txt
txt: txt/cord-287266-sd5izamc.txt
title:
  EIF4A2 interacts with the membrane protein of transmissible gastroenteritis coronavirus and plays a role in virus replication

summary:
  After blotting with 5% BSA (bovine serum albumin, BBI), the cells were incubated with TGEV M protein (1:100) mAb and rabbit pAb to EIF4A2 (1:50) overnight at 4°C. In addition, the gene of M protein is highly conserved and encoded a decisive protein for viral proliferation (ZHENHUI Song et al., 2015) .


id: cord-257136-zpeh8pmc
author: Huang, Xin
date: 2019-04-26
extension: .txt
mime: text/plain
words: 3980
sentence: 149
flesch: 46
cache: cache/cord-257136-zpeh8pmc.txt
txt: txt/cord-257136-zpeh8pmc.txt
title:
  A TaqMan-probe-based multiplex real-time RT-qPCR for simultaneous detection of porcine enteric coronaviruses

summary:
  To develop a simple, rapid, accurate, and high-throughput detection method for diagnosis and differential diagnosis on swine enteric coronaviruses, specific primers and probes were designed based on the highly conserved regions of transmissible gastroenteritis virus (TGEV) N, porcine epidemic diarrhea virus (PEDV) M, porcine deltacoronavirus (PDCoV) M, and porcine enteric alphacoronavirus (PEAV) N genes respectively. This well-established multiplex real-time RT-qPCR assay provided a rapid, efficient, specific, and sensitive tool for detection of swine enteric coronaviruses.


id: cord-269720-o81j3d1j
author: Page, Kevin W.
date: 1990
extension: .txt
mime: text/plain
words: 3559
sentence: 125
flesch: 51
cache: cache/cord-269720-o81j3d1j.txt
txt: txt/cord-269720-o81j3d1j.txt
title:
  Sequence analysis of the leader RNA of two porcine coronaviruses: Transmissible gastroenteritis virus and porcine respiratory coronavirus

summary:
  An oligonucleotide, oligo 58, was synthesised that was complementary to the 5' end of the TGEV and PRCV leader RNA sequences (Fig. 1) . In this paper we describe the elucidation of the leader RNA sequences from the porcine coronaviruses TGEV and PRCV, the first leader sequence to be described from the TGEV serogroup of coronaviruses.


id: cord-282344-o1rkx2z4
author: Kim, Seung Won
title: Effects of humidity and other factors on the generation and sampling of a coronavirus aerosol
date: 2007-07-25
extension: .txt
mime: text/plain
words: 5083
sentence: 205
flesch: 47
cache: cache/cord-282344-o1rkx2z4.txt
txt: txt/cord-282344-o1rkx2z4.txt
summary:
  Aerosolization efficiencies were also higher at lower RH, and BioSamplers collected airborne TGEV viruses at a significantly higher efficiency than AGI-30 samplers at 30 and 50% RH. To measure the degree to which the nebulizers generated airborne viruses that could be sampled and remain viable, aerosolization efficiency, g A , was calculated in the same way as Adams et al. (1982) : in which N a is the total number of viruses recovered from airborne sampling and N n is the total number of viruses aerosolized from the nebulizer during a test.


id: cord-292019-rfu0bkag
author: Gómez, N.
date: 1998-09-30
extension: .txt
mime: text/plain
words: 3601
sentence: 116
flesch: 35
cache: cache/cord-292019-rfu0bkag.txt
txt: txt/cord-292019-rfu0bkag.txt
title:
  Expression of Immunogenic Glycoprotein S Polypeptides from Transmissible Gastroenteritis Coronavirus in Transgenic Plants

summary:
  key: cord-292019-rfu0bkag authors: Gómez, N.; Carrillo, C.; Salinas, J.; Parra, F.; Borca, M. V.; Escribano, J. M. title: Expression of Immunogenic Glycoprotein S Polypeptides from Transmissible Gastroenteritis Coronavirus in Transgenic Plants date: 1998-09-30 journal: Virology DOI: 10.1006/viro.1998.9315 sha: doc_id: 292019 cord_uid: rfu0bkag Abstract The use of transgenic plants as vaccine production systems was described recently. We report on the immunological response elicited by two recombinant versions of the glycoprotein S from the swine-transmissible gastroenteritis coronavirus (TGEV) expressed in transgenic plants.


id: cord-256316-1odgm6hm
author: Godet, Murielle
title: TGEV corona virus ORF4 encodes a membrane protein that is incorporated into virions
date: 1992-06-30
extension: .txt
mime: text/plain
words: 5452
sentence: 197
flesch: 41
cache: cache/cord-256316-1odgm6hm.txt
txt: txt/cord-256316-1odgm6hm.txt
summary:
  Three days before fusion, the mice were boosted both intraperitoneally and subcutaneously with ORF4 protein purified from 4 X 10' infected cells by 15% SDS-PAGE. ORF4 product is a membrane-associated protein Indirect immunofluorescence assays were performed to determine the subcellular location of ORF4 protein.


id: cord-290640-kh2t0kfz
author: O'Connor, Jennifer Black
title: Downstream Ribosomal Entry for Translation of Coronavirus TGEV Gene 3b
date: 2000-03-30
extension: .txt
mime: text/plain
words: 6002
sentence: 173
flesch: 42
cache: cache/cord-290640-kh2t0kfz.txt
txt: txt/cord-290640-kh2t0kfz.txt
summary:
  These results, therefore, are not fully consistent with the leaky scanning model for ORF 3b Translation of ORF 3b is not blocked by the upstream insertion of an 884-nt-long sequence containing three sequential ORFs To test for an internal entry of ribosomes onto ORF 3b, pORF3a-3b-4 was modified to psCATORF3a-3b-4 by the placement of an 884-nt-long sequence containing three sequential ORFs upstream of ORF 3a (Fig. 1C ) and the products of translation were quantitated. In the case of TGEV ORF 3b shunting reported here, a requirement for an upstream structure seems unlikely, since shunting took place in the presence of foreign sequence (psCATORF3a-3b-4) as well as (relatively) native sequence (pORF3a-3b-4) at the 5Ј terminus.


id: cord-315780-uhi66unn
author: Paton, David
date: 1997-07-31
extension: .txt
mime: text/plain
words: 2908
sentence: 103
flesch: 45
cache: cache/cord-315780-uhi66unn.txt
txt: txt/cord-315780-uhi66unn.txt
title:
  Detection of transmissible gastroenteritis virus by RT-PCR and differentiation from porcine respiratory coronavirus

summary:
  A comparative examination using CF, PLA and NPLA assays The multiplication of transmissible gastroenteritis viruses in several cell lines originated from porcine kidney and effects of trypsin on the growth of the viruses Molecular differentiation of transmissible gastroenteritis virus and porcine respiratory coronavirus strains Classical transmissible gastroenteritis returns Porcine respiratory coronavirus: molecular features and virus-host interactions Pathogenicity of experimental infection with pneumotropic porcine coronavirus Transmissible gastroenteritis Diagnosis of transmissible gastroenteritis in pigs by means of immunofluorescence Isolation of a porcine respiratory, non-enteric coronavirus related to transmissible gastroenteritis Development of a detection system for woody plants based on PCR analysis of immobilized virions Transmissible gastroenteritis coronavirus, but not the related porcine respiratory coronavirus, has a sialic acid (N-glycolylneuramic acid) binding activity In situ hybridization technique for the detection of swine enteric and respiratory coronaviruses, transmissible gastroenteritis virus (TGEV) and porcine respiratory coronavirus (PRCV), in formalin-fixed paraffin-embedded tissues Region-specific initiation of mouse mammary tumour virus RNA synthesis by endogenous RNA polymerase II in preparations of cell nuclei The sensitivity of the RT-PCR for virus detection in culture fluids was compared with cell culture virus isolation.


id: cord-269094-6aka052v
author: Ortego, Javier
date: 2007-11-25
extension: .txt
mime: text/plain
words: 6067
sentence: 188
flesch: 38
cache: cache/cord-269094-6aka052v.txt
txt: txt/cord-269094-6aka052v.txt
title:
  Absence of E protein arrests transmissible gastroenteritis coronavirus maturation in the secretory pathway

summary:
  Studies of the rTGEV-ΔE subcellular localization by confocal and immunoelectron microscopy in infected E(−) cells showed that in the absence of E protein virus trafficking was arrested in the intermediate compartment. key: cord-269094-6aka052v authors: Ortego, Javier; Ceriani, Juan E.; Patiño, Cristina; Plana, Juan; Enjuanes, Luis title: Absence of E protein arrests transmissible gastroenteritis coronavirus maturation in the secretory pathway date: 2007-11-25 journal: Virology DOI: 10.1016/j.virol.2007.05.032 sha: doc_id: 269094 cord_uid: 6aka052v A recombinant transmissible gastroenteritis coronavirus (rTGEV) in which E gene was deleted (rTGEV-ΔE) has been engineered.


id: cord-270586-ohs8z91m
author: Ballesteros, M. L.
date: 1997-01-20
extension: .txt
mime: text/plain
words: 6050
sentence: 236
flesch: 48
cache: cache/cord-270586-ohs8z91m.txt
txt: txt/cord-270586-ohs8z91m.txt
title:
  Two Amino Acid Changes at the N-Terminus of Transmissible Gastroenteritis Coronavirus Spike Protein Result in the Loss of Enteric Tropism

summary:
  Sá nchez et al., 1990) using optimum amounts of virus Viruses were grown in swine testis (ST) cells (McClur-(0.5 mg of protein per well). Initial attempts to isolate TGEV recombinant viruses The calculated data indicate that the frequency of recomusing selective pressure with neutralizing MAbs specific binant isolation at the 5 of the S gene was 3.7-fold higher for a single epitope lead to the isolation of neutralization than that of Group 2 recombinants.


id: cord-283378-brdtsi65
author: Maragkoudakis, Petros A.
date: 2010-07-31
extension: .txt
mime: text/plain
words: 5030
sentence: 150
flesch: 37
cache: cache/cord-283378-brdtsi65.txt
txt: txt/cord-283378-brdtsi65.txt
title:
  Lactic acid bacteria efficiently protect human and animal intestinal epithelial and immune cells from enteric virus infection

summary:
  Very few attempts have been made only recently to study the impact and potential benefit of probiotic strains on animal cell lines. A variable increase (of up to 50%) on the release of NO(−) and H(2)O(2) (ROS) was obtained when LAB strains were co-incubated with the cell lines, but the results were found to be LAB strain and cell line specific, apart from a small number of strains which were able to induce strong ROS release in more than one cell line.


id: cord-309446-j0suk34b
author: Wesley, Ronald D.
date: 1993-12-31
extension: .txt
mime: text/plain
words: 2755
sentence: 121
flesch: 54
cache: cache/cord-309446-j0suk34b.txt
txt: txt/cord-309446-j0suk34b.txt
title:
  Immunization of pregnant gilts with PRCV induces lactogenic immunity for protection of nursing piglets from challenge with TGEV

summary:
  Of the six protected gilts, five had lower VN titers in the 10day milk samples than in the colostral samples, and the VN titer of gilt # 6 TABLE 5 Serological response of PRCV vaccinated gilts to TGEV challenge of their litter DISCUSSION Our results indicate that experimental vaccination of seronegative, naive gilts with PRCV induces lactogenic immunity against TGE. On average, litters of control gilts lost weight more rapidly than those of PRCV-vaccinated gilts; however, only differences in the day 1 PC weights were significant at the 95% confidence level (P= 0.04).


id: cord-296033-5zyoddl7
author: Hu, Xiaoliang
date: 2017-10-23
extension: .txt
mime: text/plain
words: 3385
sentence: 146
flesch: 43
cache: cache/cord-296033-5zyoddl7.txt
txt: txt/cord-296033-5zyoddl7.txt
title:
  Transmissible Gastroenteritis Virus Papain-Like Protease 1 Antagonizes Production of Interferon-β through Its Deubiquitinase Activity

summary:
  However, very little is known about whether TGEV PL1 can antagonize host innate immune response. Here, we presented evidence that TGEV PL1 encoded by the replicase gene could suppress the IFN-β expression and inhibit the nuclear translocation of interferon regulatory factor 3 (IRF3).


id: cord-293945-gyb9mjb5
author: Chai, Weidong
date: 2012-11-28
extension: .txt
mime: text/plain
words: 4313
sentence: 162
flesch: 37
cache: cache/cord-293945-gyb9mjb5.txt
txt: txt/cord-293945-gyb9mjb5.txt
title:
  Antiviral effects of a probiotic Enterococcus faecium strain against transmissible gastroenteritis coronavirus

summary:
  To assess the potential prophylactic or therapeutic effect of the probiotic bacteria E. faecium on TGEV infection, increasing concentrations of probiotic E. faecium bacteria were added to ST cells before, concomitantly with, or after TGEV infection for a short period of time, and cell viability as well as virus titers in the culture medium were quantitatively assessed later after long-term incubation. We have studied the protective effects of the probiotic Enterococcus faecium NCIMB 10415 (E. faecium), which is approved as a feed additive in the European Union, against TGEV infection.


id: cord-299189-59d4aojh
author: Zou, Hao
date: 2013-07-02
extension: .txt
mime: text/plain
words: 4571
sentence: 178
flesch: 46
cache: cache/cord-299189-59d4aojh.txt
txt: txt/cord-299189-59d4aojh.txt
title:
  Transmissible gastroenteritis virus: Identification of M protein-binding peptide ligands with antiviral and diagnostic potential

summary:
  In the current study, three TGEV M-binding phage and the concomitant peptides were identified from a phage display library. key: cord-299189-59d4aojh authors: Zou, Hao; Zarlenga, Dante S.; Sestak, Karol; Suo, Siqingaowa; Ren, Xiaofeng title: Transmissible gastroenteritis virus: Identification of M protein-binding peptide ligands with antiviral and diagnostic potential date: 2013-07-02 journal:


id: cord-288058-oilurica
author: Cui, Tingting
date: 2020-04-05
extension: .txt
mime: text/plain
words: 7089
sentence: 286
flesch: 49
cache: cache/cord-288058-oilurica.txt
txt: txt/cord-288058-oilurica.txt
title:
  Role of Porcine Aminopeptidase N and Sialic Acids in Porcine Coronavirus Infections in Primary Porcine Enterocytes

summary:
  PEDV and TGEV Miller showed a higher infectivity in APN positive cells than in APN negative cells. For CV777 Vero adapted strain, 0.040 ± 0.002% of APN positive cells and 0.020 ± 0.006% of APN negative cells were infected.


id: cord-322238-8iwljdoi
author: Chen, Qin
date: 2010-08-29
extension: .txt
mime: text/plain
words: 1714
sentence: 69
flesch: 44
cache: cache/cord-322238-8iwljdoi.txt
txt: txt/cord-322238-8iwljdoi.txt
title:
  Detection of swine transmissible gastroenteritis coronavirus using loop-mediated isothermal amplification

summary:
  The sensitivity of LAMP was demonstrated by comparing with PCR tests using serial dilutions (10 -1 to 10 -7 ) of TGEV RNA samples as template. Five other pig viruses were used to confirm the specificity of the LAMP for TGEV detection.


id: cord-274424-juj71nc5
author: Pulford, David J.
date: 1991-06-30
extension: .txt
mime: text/plain
words: 4928
sentence: 165
flesch: 41
cache: cache/cord-274424-juj71nc5.txt
txt: txt/cord-274424-juj71nc5.txt
title:
  Intracellular processing of the porcine coronavirus transmissible gastroenteritis virus spike protein expressed by recombinant vaccinia virus

summary:
  TGEV S protein steadily became Endo H resistant with time such that after a 4-hr chase virtually all S protein had been modified in the Golgi. The acquisition of Endo H resistance was significantly retarded for recombinant S protein compared to S protein expressed during a TGEV infection.


id: cord-287602-vda01gj6
author: Jin, Yu-Bei
date: 2018-07-18
extension: .txt
mime: text/plain
words: 6505
sentence: 200
flesch: 41
cache: cache/cord-287602-vda01gj6.txt
txt: txt/cord-287602-vda01gj6.txt
title:
  Immune responses induced by recombinant Lactobacillus plantarum expressing the spike protein derived from transmissible gastroenteritis virus in piglets

summary:
  In previous reports, this vaccine strategy offered a variety of benefits in that the constructed L. plantarum expression of protein-fused DCpep could activate mucosal DCs, B cells, and T cells to induce the immunological response and could regulate inflammatory responses that took place in a mucosal microenvironment (Steinman and Idoyaga 2010) . Another reasonable explanation is that DCpep may also be recognized by B cells which some B cells also have antigenpresenting function, which subsequently presented the antigens to T cells with APC function.


id: cord-275780-76v61ktj
author: Wu, Aimin
date: 2020-01-20
extension: .txt
mime: text/plain
words: 6497
sentence: 278
flesch: 47
cache: cache/cord-275780-76v61ktj.txt
txt: txt/cord-275780-76v61ktj.txt
title:
  Transmissible gastroenteritis virus targets Paneth cells to inhibit the self-renewal and differentiation of Lgr5 intestinal stem cells via Notch signaling

summary:
  One of the central mechanisms to maintain intestinal barrier function is through activating crypt cells (Paneth cells and intestinal stem cells, ISCs) 5 . The role of Hes genes in intestinal development, homeostasis and tumor formation Dll1-and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny Replacement of lost Lgr5-positive stem cells through plasticity of their enterocyte-lineage daughters Impaired Wnt/beta-catenin pathway leads to dysfunction of intestinal regeneration during necrotizing enterocolitis Robust cre-mediated recombination in small intestinal stem cells utilizing the olfm4 locus Stem cells and the impact of ROS signaling TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling The canonical Notch signaling pathway: unfolding the activation mechanism Intact function of Lgr5 receptorexpressing intestinal stem cells in the absence of Paneth cells Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells Tales from the crypt: new insights into intestinal stem cells Wnt ligands secreted by subepithelial mesenchymal cells are essential for the survival of intestinal stem cells and gut homeostasis Transmissible gastroenteritis of swine: virus-intestinal cell interactions.


id: cord-291192-wm2eyaam
author: Becares, Martina
title: Antigenic structures stably expressed by recombinant TGEV-derived vectors
date: 2014-08-09
extension: .txt
mime: text/plain
words: 9561
sentence: 337
flesch: 39
cache: cache/cord-291192-wm2eyaam.txt
txt: txt/cord-291192-wm2eyaam.txt
summary:
  Altogether, these results indicated that expression of PRRSV M protein in rTGEV was fully stable. Expression of small domains of PRRSV GP5 protein using rTGEV PRRSV M protein is a potent inducer of T-cell proliferation in piglets infected with PRRSV, and may also play a role in protection (Bautista et al., 1999; Jeong et al., 2010) .


id: cord-309693-f2htekhz
author: Yu, Meiling
date: 2017-09-25
extension: .txt
mime: text/plain
words: 6011
sentence: 182
flesch: 38
cache: cache/cord-309693-f2htekhz.txt
txt: txt/cord-309693-f2htekhz.txt
title:
  Immunogenicity of eGFP-Marked Recombinant Lactobacillus casei against Transmissible Gastroenteritis Virus and Porcine Epidemic Diarrhea Virus

summary:
  The proliferation of spleen lymphocytes upon stimulation with purified COE or 6D proteins was analyzed by an MTT assay. The The proliferation of spleen lymphocytes upon stimulation with purified COE or 6D proteins was analyzed by an MTT assay.


id: cord-293458-jb7u9xn6
author: Gerdts, Volker
title: Vaccines for porcine epidemic diarrhea virus and other swine coronaviruses
date: 2016-12-02
extension: .txt
mime: text/plain
words: 5584
sentence: 219
flesch: 43
cache: cache/cord-293458-jb7u9xn6.txt
txt: txt/cord-293458-jb7u9xn6.txt
summary:
  Induction of antigen-specific systemic and mucosal immune responses by feeding animals transgenic plants expressing the antigen Efficacy of an inactivated genotype 2b porcine epidemic diarrhea virus vaccine in neonatal piglets Colostral antibodymediated and cell-mediated immunity contributes to innate and antigenspecific immunity in piglets Mechanisms of coronavirus cell entry mediated by the viral spike protein Development of a Novel Vaccine for Porcine Epidemic Diarrhea Virus Passive immunity in transmissible gastroenteritis of swine: immunoglobulin characteristics of antibodies in milk after inoculating virus by different routes Immunology of transmissible gastroenteritis Antibody responses in serum, colostrum, and milk of swine after infection or vaccination with transmissible gastroenteritis virus Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity New insights into the dual recruitment of IgA+ B cells in the developing mammary gland Identification of the epitope region capable of inducing neutralizing antibodies against the porcine epidemic diarrhea virus T cell-mediated immune response to respiratory coronaviruses Strategies for design and application of enteric viral vaccines p161, a murine membrane protein expressed on mast cells and some macrophages, is mouse CD13/aminopeptidase N Protective efficacy of a replicon particle vaccine in both naïve and previously exposed gilts against porcine epidemic diarrhea virus Coronavirus gene 7 counteracts host defenses and modulates virus virulence Porcine epidemic diarrhea virus nucleocapsid protein antagonizes beta interferon production by sequestering the interaction between IRF3 and TBK1 Safety and antibody response of pigs to an experimental Porcine Epidemic Diarrhea Virus (PEDV) vaccine, killed virus Previous infection of sows with a mild strain of porcine epidemic diarrhea virus confers protection against infection with a severe strain Evaluation of a PED vaccine on piglet mortality and sow immunity The phenotype and activation status of T and NK cells in porcine colostrum suggest these are central/effector memory cells Antibodies and their receptors: different potential roles in mucosal defense Surface-displayed porcine epidemic diarrhea viral (PEDV) antigens on lactic acid bacteria Porcine epidemic diarrhea virus uses cell-surface heparan sulfate as an attachment factor Porcine epidemic diarrhea virus infection: etiology, epidemiology, pathogenesis and immunoprophylaxis Porcine reproductive and respiratory syndrome virus modifies innate immunity and alters disease outcome in pigs subsequently infected with porcine respiratory coronavirus: implications for respiratory viral co-infections Genetic characterization of porcine epidemic diarrhea virus in Korea from IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex Lactogenic immunity and vaccines for porcine epidemic diarrhea virus (PEDV): historical and current concepts Replication of transmissible gastroenteritis coronavirus (TGEV) in swine alveolar macrophages A common mucosal chemokine (mucosae-associated epithelial chemokine/CCL28) selectively attracts IgA plasmablasts Outbreak-related porcine epidemic diarrhea virus strains similar to US strains, South Korea Porcine epidemic diarrhea virus: an emerging and re-emerging epizootic swine virus Porcine aminopeptidase N is a functional receptor for the PEDV coronavirus High-level mucosal and systemic immune responses induced by oral administration with Lactobacillusexpressed porcine epidemic diarrhea virus (PEDV) CCL28 controls immunoglobulin (Ig)A plasma cell accumulation in the lactating mammary gland and IgA antibody transfer to the neonate Porcine epidemic diarrhea virus E protein causes endoplasmic reticulum stress and up-regulates interleukin-8 expression Porcine epidemic diarrhea virus N protein prolongs S-phase cell cycle, induces endoplasmic reticulum stress, and up-regulates interleukin-8 expression Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients Efficacy and immunogenicity of recombinant swinepox virus expressing the A epitope of the TGEV S protein Immune evasion of porcine enteric coronaviruses and viral modulation of antiviral innate signaling Identification of a conserved linear B-cell epitope in the M protein of porcine epidemic diarrhea virus Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1 Construction of a bivalent DNA vaccine co-expressing S genes of transmissible gastroenteritis virus and porcine epidemic diarrhea virus delivered by attenuated Salmonella typhimurium Mucosal and systemic isotypespecific antibody responses and protection in conventional pigs exposed to virulent or attenuated porcine epidemic diarrhoea virus


id: cord-346643-os2kyvvf
author: Wang, Li
date: 2016-11-15
extension: .txt
mime: text/plain
words: 2959
sentence: 137
flesch: 53
cache: cache/cord-346643-os2kyvvf.txt
txt: txt/cord-346643-os2kyvvf.txt
title:
  Inhibition of porcine transmissible gastroenteritis virus infection in porcine kidney cells using short hairpin RNAs targeting the membrane gene

summary:
  Non-transfected cells were used as a Virus Genes (2017) 53:226-232 227 control. The analysis of cytopathic effects demonstrated that pRNAT-2 and pRNAT-3 could protect PK-15 cells against pathological changes specifically and efficiently.


id: cord-290282-oxyzndsj
author: Ortego, Javier
date: 2003-03-30
extension: .txt
mime: text/plain
words: 4324
sentence: 150
flesch: 45
cache: cache/cord-290282-oxyzndsj.txt
txt: txt/cord-290282-oxyzndsj.txt
title:
  Transmissible gastroenteritis coronavirus gene 7 is not essential but influences in vivo virus replication and virulence

summary:
  rTGEV in which gene 7 expression was abrogated (rTGEV-Δ7) were recovered from cDNA constructs, indicating that TGEV gene 7 was a nonessential gene for virus replication. The 3Ј end of the majority of TGEV genes overlaps with the 5Ј terminus of the next gene (Enjuanes et al., 2000b) , complicating insertion of heterologous genes into the viral genome and deletion of different genes to determine whether they are essential.


id: cord-317462-nvrl0vyi
author: Song, Zhenhui
date: 2016-09-28
extension: .txt
mime: text/plain
words: 3374
sentence: 121
flesch: 46
cache: cache/cord-317462-nvrl0vyi.txt
txt: txt/cord-317462-nvrl0vyi.txt
title:
  Morphogenesis and proliferative rule of porcine transmissible gastroenteritis virus in porcine intestinal epithelial cells

summary:
  To detect whether TGEV propagated in porcine IECs cells could infect ST cells, ST cells were infected by the supernatant of IECs infected with TGEV for 24 h. A monoclonal antibody against the TGEV nucleoprotein (NP), at a 1:200 dilution, was used to detect infected cells. In this study, TGEV particles in porcine epithelial cells were observed to have a diameter ranging from 80 to 120 nm, which was consistent with previous reports.


id: cord-310467-v2wlu5eq
author: Tô, Long-Thành
date: 1992-10-02
extension: .txt
mime: text/plain
words: 4089
sentence: 125
flesch: 36
cache: cache/cord-310467-v2wlu5eq.txt
txt: txt/cord-310467-v2wlu5eq.txt
title:
  Effect of fixation on the detection of transmissible gastroenteritis coronavirus antigens by the fixed-cell immunoperoxidase technique

summary:
  The degree of antibody binding to the N determinant in cells fixed with 80% acetone after their incubation with MAb was equal to that of controls but considerably lower than that of infected cells which were fixed with 80% acetone prior to their incubation with MAb. When cell fixation occurred at 4°C, an increase in acetone concentration led to poor detection of M and S determinants although the latter could be detected in cells which were fixed with 70% or 80% acetone (Fig. 2b) .


id: cord-344558-1jgqofbr
author: Kocherhans, Rolf
title: Completion of the Porcine Epidemic Diarrhoea Coronavirus (PEDV) Genome Sequence
date: 2001
extension: .txt
mime: text/plain
words: 2841
sentence: 147
flesch: 61
cache: cache/cord-344558-1jgqofbr.txt
txt: txt/cord-344558-1jgqofbr.txt
summary:
  Later, a mixture of up to six antigenome sense primers based on PEDV specific sequences or the degenerate primers and random hexamer primer (purchased from Schmidheini AG; Balgach, Switzerland) was used for first strand cDNA synthesis. The multiple sequence alignments revealed several putative functional domains common to coronavirus sequences [23, 26] located on the deduced amino acid sequence of ORF1ab of PEDV.


id: cord-290883-r2744fb3
author: TORRES, JUAN M.
date: 1995-11-30
extension: .txt
mime: text/plain
words: 7346
sentence: 261
flesch: 45
cache: cache/cord-290883-r2744fb3.txt
txt: txt/cord-290883-r2744fb3.txt
title:
  Induction of Antibodies Protecting against Transmissible Gastroenteritis Coronavirus (TGEV) by Recombinant Adenovirus Expressing TGEV Spike Protein

summary:
  When immunofluorescence was performed with a human Ad5-specific MAb (which binds 72K protein) bright fluorescence was observed on discrete though amino acids 380 to 387 of S protein site D are areas of the nucleus, but not in the cytoplasm (results coded by recombinant Ad-TS5, this site was poorly recnot shown), in contrast to the cytoplasmic fluorescence ognized by MAb 1D.G3 specific for D site on Ad-TS5observed with TGEV-specific MAbs. Neutralization of nant Ad5 viruses expressing TGEV S gene fragments TGEV was performed by incubating serial 10-fold dilu-(Ad-TS) is summarized in Fig.


id: cord-326719-p1ma4akz
author: Enjuanes, Luis
title: Virus-based vectors for gene expression in mammalian cells: Coronavirus
date: 2003-12-31
extension: .txt
mime: text/plain
words: 5934
sentence: 269
flesch: 51
cache: cache/cord-326719-p1ma4akz.txt
txt: txt/cord-326719-p1ma4akz.txt
summary:
  The coronaviruses have been classified into three groups (1, 2 and 3) based on sequence analysis of a number of coronavirus genes [1] . key: cord-326719-p1ma4akz authors: Enjuanes, Luis; Almazán, Fernando; Ortego, Javier title: Virus-based vectors for gene expression in mammalian cells: Coronavirus date: 2003-12-31 journal: New Comprehensive Biochemistry DOI: 10.1016/s0167-7306(03)38010-x sha: doc_id: 326719 cord_uid: p1ma4akz Publisher Summary The coronavirus and the torovirus genera form the Coronaviridae family, which is closely related to the Arteriviridae family.


id: cord-304014-k62mtr9j
author: Ma, Xuelian
date: 2019-11-04
extension: .txt
mime: text/plain
words: 4482
sentence: 237
flesch: 49
cache: cache/cord-304014-k62mtr9j.txt
txt: txt/cord-304014-k62mtr9j.txt
title:
  Identification and analysis of long non-coding RNAs that are involved in inflammatory process in response to transmissible gastroenteritis virus infection

summary:
  Among them, 215 were antisense lncRNAs, 1427 long intervening/intergenic non-coding RNAs (lincRNAs), 220 other lncRNAs, 24 Promoter-associated lncRNAs, 115 sense overlapping lncRNAs, and 22 UTR lncRNAs ( Fig. Among 106 lncRNAs, 16 were antisense lncRNAs, 79 lincRNAs, 5 other lncRNAs, 2 Promoter-associated lncRNAs, 3 sense overlapping lncRNAs, and 1 UTR lncRNAs (Fig. 1d) .


id: cord-332317-wrztpeb8
author: Zhang, Xin
date: 2015-03-16
extension: .txt
mime: text/plain
words: 3986
sentence: 168
flesch: 42
cache: cache/cord-332317-wrztpeb8.txt
txt: txt/cord-332317-wrztpeb8.txt
title:
  Identification of the interaction between vimentin and nucleocapsid protein of transmissible gastroenteritis virus

summary:
  To confirm the interaction between N protein of TGEV and cellular vimentin, immunoprecipitation assay was utilized to identify whether TGEV N protein interacted with cellular vimentin in TGEVinfected ST cells. The present study thus provides protein-related information about interaction of TGEV N protein with host cell that should be useful for understanding host cell response to coronavirus pathogenesis infection and the underlying mechanism of coronavirus replication.


id: cord-315688-ba5dus2j
author: He, Lei
date: 2012-08-28
extension: .txt
mime: text/plain
words: 4322
sentence: 166
flesch: 47
cache: cache/cord-315688-ba5dus2j.txt
txt: txt/cord-315688-ba5dus2j.txt
title:
  In vitro inhibition of transmissible gastroenteritis coronavirus replication in swine testicular cells by short hairpin RNAs targeting the ORF 7 gene

summary:
  Transmissible gastroenteritis of pigs Genetic basis for the pathogenesis of transmissible gastroenteritis virus Binding of transmissible gastroenteritis coronavirus to brush border membrane sialoglycoproteins Mucosal immunisation and adjuvants: a brief overview of recent advances and challenges Increased litter survival rates, reduced clinical illness and better lactogenic immunity against TGEV in gilts that were primed as neonates with porcine respiratory coronavirus (PRCV) Cellular immune responses of pigs after primary inoculation with porcine respiratory coronavirus or transmissible gastroenteritis virus and challenge with transmissible gastroenteritis virus RNA silencing: a conserved antiviral immunity of plants and animals Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans RNA interference targeting nucleocapsid protein (C) inhibits classical swine fever virus replication in SK-6 cells Adenovirus-mediated RNA interference against foot-and-mouth disease virus infection both in vitro and in vivo In vitro inhibition of classical swine fever virus replication by siRNAs targeting Npro and NS5B genes Effective inhibition of porcine transmissible gastroenteritis virus replication in ST cells by shRNAs targeting RNA-dependent RNA polymerase gene Inhibition of porcine transmissible gastroenteritis virus (TGEV) replication in mini-pigs by shRNA Coronavirus gene 7 counteracts host defenses and modulates virus virulence Biochemical aspects of coronavirus replication and virus-host interaction Site-specific alteration of transmissible gastroenteritis virus spike protein results in markedly reduced pathogenicity Transcription regulatory sequences and mRNA expression levels in the coronavirus transmissible gastroenteritis virus Molecular cloning and phylogenetic analysis of ORF7 region of chinese isolate TH-98 from transmissible gastroenteritis virus The 9-kDa hydrophobic protein encoded at the 3' end of the porcine transmissible gastroenteritis coronavirus genome is membraneassociated Sequence analysis of the ORF 7 region of transmissible gastroenteritis viruses isolated in Korea Host cell proteins interacting with the 3' end of TGEV coronavirus genome influence virus replication Transmissible gastroenteritis coronavirus gene 7 is not essential but influences in vivo virus replication and virulence Protection of chickens after live and inactivated virus vaccination against challenge with nephropathogenic infectious bronchitis virus PA/Wolgemuth/98 Safety and efficacy of a modified-live canine coronavirus vaccine in dogs Simultaneously inhibition of HIV and HBV replication through a dual small interfering RNA expression system In vitro inhibition of CSFV replication by retroviral vector-mediated RNA interference A transgenic approach for RNA interferencebased genetic screening in mice A system for stable expression of short interfering RNAs in mammalian cells A large-scale RNAi screen in human cells identifies new components of the p53 pathway Short interfering RNA confers intracellular antiviral immunity in human cells Targeting Marek's disease virus by RNA interference delivered from a herpesvirus vaccine Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs Transmissible gastroenteritis virus induces apoptosis in swine testicular cell lines but not in intestinal enterocytes The viral nucleocapsid protein of transmissible gastroenteritis coronavirus (TGEV) is cleaved by caspase-6 and â��7 during TGEV-induced apoptosis Observation of the cytopathic effect and apoptosis, as well as a cell proliferation assay demonstrated that the three shRNAs were capable of protecting ST cells against TGEV destruction, with high specificity and efficiency.


id: cord-324098-9x18bidq
author: DING, Li
title: p53- and ROS-mediated AIF pathway involved in TGEV-induced apoptosis
date: 2018-09-25
extension: .txt
mime: text/plain
words: 2844
sentence: 129
flesch: 39
cache: cache/cord-324098-9x18bidq.txt
txt: txt/cord-324098-9x18bidq.txt
summary:
  Thus, to investigate whether AIF pathway was activated in TGEV-induced apoptosis in PK-15 cells, the protein levels of AIF in mitochondrial and nuclear fractions were measured by Western blot. These results suggest that AIF pathway might be involved in TGEV-induced apoptosis.


id: cord-312210-3x9s3g8n
author: Stoian, Ana
date: 2019-12-24
extension: .txt
mime: text/plain
words: 3454
sentence: 144
flesch: 53
cache: cache/cord-312210-3x9s3g8n.txt
txt: txt/cord-312210-3x9s3g8n.txt
title:
  The use of cells from ANPEP knockout pigs to evaluate the role of aminopeptidase N (APN) as a receptor for porcine deltacoronavirus (PDCoV)

summary:
  Together, the RT-PCR and serological results showed that ANPEP KO pigs are not resistant to infection with PDCoV. The results from this study showed no PDCoV infection of PAMs obtained from ANPEP KO pigs (see Fig. 1A ), which supports the observations of Wang et al. Porcine alveolar macrophages from ANPEP KO pigs were resistant to PDCoV and TGEV.


id: cord-339178-d6f6a5ds
author: Pensaert, M. B.
title: A new coronavirus-like particle associated with diarrhea in swine
date: 1978
extension: .txt
mime: text/plain
words: 1750
sentence: 79
flesch: 52
cache: cache/cord-339178-d6f6a5ds.txt
txt: txt/cord-339178-d6f6a5ds.txt
summary:
  Diarrhea was reproduced in experimental pigs with one of the isolates, designated CV777, which was found to be distinct from the 2 known porcine coronaviruses, transmissible gastroenteritis virus and hemagglutinating encephalomyelitis virus. Diarrhea was reproduced in experimental pigs with one of the isolates, designated CV777, which was found to be distinct from the 2 known porcine coronaviruses, transmissible gastroenteritis virus and hemagglutinating encephalomyelitis virus.


id: cord-341015-45kbggzk
author: Galán, Carmen
date: 2006
extension: .txt
mime: text/plain
words: 1158
sentence: 46
flesch: 45
cache: cache/cord-341015-45kbggzk.txt
txt: txt/cord-341015-45kbggzk.txt
title:
  Differential role of N-Terminal Polyprotein Processing in Coronavirus Genome Replication and Minigenome Amplification

summary:
  In the present study, we characterize by reverse genetics the effect of a point mutation at position 637, which mapped in the putative PLP-1 cleavage site at the p9/p87 junction, on TGEV and minigenome replication. M33L and DI-C cDNAs with point mutations at position 637 were generated by restriction fragment exchange from plasmids with the corresponding mutations.


id: cord-302503-7s9f8wje
author: Fu, Yuguang
title: Rapid and efficient detection methods of pathogenic swine enteric coronaviruses
date: 2020-05-19
extension: .txt
mime: text/plain
words: 6360
sentence: 160
flesch: 33
cache: cache/cord-302503-7s9f8wje.txt
txt: txt/cord-302503-7s9f8wje.txt
summary:
  Multiplex nested RT-PCR for the detection of porcine enteric viruses SARS-CoV and emergent coronaviruses: viral determinants of interspecies transmission Field validation of a commercial blocking ELISA to differentiate antibody to transmissible gastroenteritis virus (TGEV) and porcine respiratory coronavirus and to identify TGEV-infected swine herds Deletion screening of the Duchenne muscular dystrophy locus via multiplex DNA amplification Interspecies transmission and emergence of novel viruses: lessons from bats and birds Complete genome sequence of a variant porcine epidemic diarrhea virus strain isolated in China Full-length genome characterization of Chinese porcine deltacoronavirus strain CH/ SXD1/2015 Molecular epidemiology of porcine epidemic diarrhea virus in China Pathogenicity and pathogenesis of a United States porcine deltacoronavirus cell culture isolate in 5-day-old neonatal piglets Detection and characterization of group C rotaviruses in asymptomatic piglets in Ireland Development of a multiplex RT-PCR for the detection of major diarrhoeal viruses in pig herds in China Transmissible gastroenteritis virus infection induces NF-kappaB activation through RLR-mediated signaling Porcine deltacoronavirus in mainland China A transmissible gastroenteritis in pigs Transmissible gastroenteritis: demonstration of the virus from field specimens by means of cell culture and pig inoculation SYBR Green real-time reverse transcription-polymerase chain reaction assay for the generic detection of coronaviruses Transmissible gastroenteritis Epidemiological survey of porcine epidemic diarrhea virus in swine farms in A new bat-HKU2-like coronavirus in swine Serological evidence of infection with a coronavirus related to transmissible gastroenteritis virus and porcine epidemic diarrhea virus Establishment and application of a multiplex RT-PCR to differentiate wild-type and vaccine strains of porcine epidemic diarrhea virus Detection, sequence analysis, and antibody prevalence of porcine deltacoronavirus in Taiwan Development of a one-step RT-PCR assay for detection of pancoronaviruses (alpha-, beta-, gamma-, and delta-coronaviruses) using newly designed degenerate primers for porcine and avian`fecal samples A TaqManprobe-based multiplex real-time RT-qPCR for simultaneous detection of porcine enteric coronaviruses Porcine deltacoronavirus infection: etiology, cell culture for virus isolation and propagation, molecular epidemiology and pathogenesis Porcine epidemic diarrhea virus infection: etiology, epidemiology, pathogenesis and immunoprophylaxis Viral load quantitation of SARS-coronavirus RNA using a one-step real-time RT-PCR Development of a reverse transcription-nested polymerase chain reaction assay for differential diagnosis of transmissible gastroenteritis virus and porcine respiratory coronavirus from feces and nasal swabs of infected pigs Multiplex real-time RT-PCR for the simultaneous detection and quantification of transmissible gastroenteritis virus and porcine epidemic diarrhea virus Differential detection of transmissible gastroenteritis virus and porcine epidemic diarrhea virus by duplex RT-PCR Isolation and serial propagation of porcine epidemic diarrhea virus in cell cultures and partial characterization of the isolate Porcine respiratory coronavirus: molecular features and virus-host interactions Detection and characterization of distinct alphacoronaviruses in five different bat species in Denmark Genetic differentiation of the nucleocapsid protein of Korean isolates of porcine epidemic diarrhoea virus by RT-PCR based restriction fragment length polymorphism analysis Complete genome characterization of Korean porcine deltacoronavirus strain KOR/KNU14-04 Full-length genome sequence of porcine deltacoronavirus strain USA/IA/2014/8734 New variants of porcine epidemic diarrhea virus, China Detection and differentiation of five diarrhea related pig viruses utilizing a multiplex PCR assay A TaqMan probe-based real-time PCR to differentiate porcine epidemic diarrhea virus virulent strains from attenuated vaccine strains Reverse transcription-PCR assays for the differentiation of various US porcine epidemic diarrhea virus strains Origin, evolution, and virulence of porcine deltacoronaviruses in the United States Rapid detection, complete genome sequencing, and phylogenetic analysis of porcine deltacoronavirus A novel pancoronavirus RT-PCR assay: frequent detection of human coronavirus NL63 in children hospitalized with respiratory tract infections in Belgium The first case of porcine epidemic diarrhea in Canada Discovery of a novel swine enteric alphacoronavirus (SeACoV) in southern China Cloning and further sequence analysis of the ORF3 gene of wild-and attenuated-type porcine epidemic diarrhea viruses Detection of transmissible gastroenteritis virus by RT-PCR and differentiation from porcine respiratory coronavirus Isolation of a porcine respiratory, non-enteric coronavirus related to transmissible gastroenteritis A new coronavirus-like particle associated with diarrhea in swine Complete genome sequence of transmissible gastroenteritis coronavirus PUR46-MAD clone and evolution of the purdue virus cluster Development of reverse transcription loop-mediated isothermal amplification for rapid detection of porcine epidemic diarrhea virus Rapid detection of swine transmissible gastroenteritis virus by nested polymerase chain reaction Comparative pathogenesis of enteric viral infections of swine Isolation of porcine epidemic diarrhea virus in porcine cell cultures and experimental infection of pigs of different ages Development and optimization of a sensitive TaqMan(R) real-time PCR with synthetic homologous extrinsic control for quantitation of Human cytomegalovirus viral load Porcine epidemic diarrhoea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccines Newly emerged porcine deltacoronavirus associated with diarrhoea in swine in China: identification, prevalence and full-length genome sequence analysis Differentiation of a Vero cell adapted porcine epidemic diarrhea virus from Korean field strains by restriction fragment length polymorphism analysis of ORF 3 Emergence of porcine epidemic diarrhea virus in the United States: clinical signs, lesions, and viral genomic sequences A novel duplex TaqMan probebased real-time RT-qPCR for detecting and differentiating classical and variant porcine epidemic diarrhea viruses An immunohistochemical investigation of porcine epidemic diarrhoea Epidemiology and vaccine of porcine epidemic diarrhea virus in China: a mini-review Outbreak of porcine epidemic diarrhea in suckling piglets An outbreak of swine diarrhea of a new-type associated with coronavirus-like particles in Japan Development of a TaqMan MGB RT-PCR for the rapid detection of H3 subtype avian influenza virus circulating in China Evidence of recombinant strains of porcine epidemic diarrhea virus Solid phase immune electron microscopy for diagnosis of transmissible gastroenteritis in pigs A real-time TaqMan RT-PCR assay with an internal amplification control for rapid detection of transmissible gastroenteritis virus in swine fecal samples A pancoronavirus RT-PCR assay for detection of all known coronaviruses Reverse transcription cross-priming amplificationnucleic acid test strip for rapid detection of porcine epidemic diarrhea virus Rapid detection of transmissible gastroenteritis virus in swine small intestine samples using real-time reverse transcription recombinase polymerase amplification Detection and genetic characterization of deltacoronavirus in pigs Development and evaluation of a duplex real-time RT-PCR for detection and differentiation of virulent and variant strains of porcine epidemic diarrhea viruses from the United States Simultaneous detection of five pig viruses associated with enteric disease in pigs using EvaGreen real-time PCR combined with melting curve analysis Evidence for a porcine respiratory coronavirus, antigenically similar to transmissible gastroenteritis virus, in the United States Coronavirus genomics and bioinformatics analysis Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus Ultrasensitive detection of porcine epidemic diarrhea virus from fecal samples using functionalized nanoparticles Whole-genome analysis of porcine epidemic diarrhea virus (PEDV) from eastern China Genetic variation analysis of reemerging porcine epidemic diarrhea virus prevailing in central China from Development of a nanoparticle-assisted PCR assay for detection of porcine epidemic diarrhea virus Porcine deltacoronavirus: overview of infection dynamics, diagnostic methods, prevalence and genetic evolution Evaluation of two singleplex reverse transcription-Insulated isothermal PCR tests and a duplex real-time RT-PCR test for the detection of porcine epidemic diarrhea virus and porcine deltacoronavirus A multiplex RT-PCR assay for rapid and differential diagnosis of four porcine diarrhea associated viruses in field samples from pig farms in East China from 2010 to 2012 Development of a multiplex TaqMan probe-based real-time PCR for discrimination of variant and classical porcine epidemic diarrhea virus Development of a TaqMan-based real-time RT-PCR assay for the detection of SADS-CoV associated with severe diarrhea disease in pigs Comparison and evaluation of conventional RT-PCR, SYBR green I and TaqMan real-time RT-PCR assays for the detection of porcine epidemic diarrhea virus Development of TaqMan real-time reverse transcription-polymerase chain reaction for the detection and quantitation of porcine kobuvirus A sensitive duplex nanoparticle-assisted PCR assay for identifying porcine epidemic diarrhea virus and porcine transmissible gastroenteritis virus from clinical specimens Establishment of a nanoparticle-assisted RT-PCR assay to distinguish field strains and attenuated strains of porcine epidemic diarrhea virus Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations In October 2010, a severe PED outbreak caused by a highly virulent PEDV variant emerged in southern China with high mortality ranging from 70 to 100%; the result was devastating damage to the pig farm industry and tremendous economic losses, and later, the PEDV variant spreads to other countries, e.g., USA, Canada, and Mexico ( For the early and rapid detection of PEDV, different types of PCR methods have been developed.


id: cord-298685-qxkxjxsz
author: Pensaert, Maurice B.
title: Porcine epidemic diarrhea: A retrospect from Europe and matters of debate
date: 2016-12-02
extension: .txt
mime: text/plain
words: 5865
sentence: 201
flesch: 45
cache: cache/cord-298685-qxkxjxsz.txt
txt: txt/cord-298685-qxkxjxsz.txt
summary:
  Surveillance and control of PED coronavirus in pig in Italy Seqence determination of the nucleocapsid protein gene of the porceni epidemic diarhoea viris confirms that this virusis a coronavirus relatyed to human coronavirus 229 E and porcine transmissible gastroenteritis virus Enzyme-linked immunosorbent assay for the detection of the coronaviruslike agent and its antibodies in pigs with porcine epidemic diarrhea Prevalence of influenza-, Aujeszky, transmissible gastroenteritis and procine epizootic diarrhea virus in feeder pigs Evaluation of a blocking ELISA using monoclonal antibodies for the detection of porcine epidemic diarrhea virus and its antibodies Porcine epidemic diarrhoea: new insights into an old disease Virus-like particles associated with porcine epidemic diarrhoea Pathogenesis comparison between the United States porcine epidemic diarrhoea virus prototype and S-INDEL-variant strains in conventional neonatal piglets Experimental infection of a US spike-insertion deletion porcine epidemic diarrhea virus in conventional nursing piglets and cross-protection to the original US PEDV infection Pathology of experimental CV777 coronavirus enteritis in piglets Porcine epidemic diarrhea virus among farmed pigs Prevalence of porcine epidemic diarrhea (PED) virus in the pig population of different countries The pathogenesis of an enteric infection in pigs experimentally induced by the coronavirus-like agent CV 777 Experimental infection of pigs with a new porcine enteric coronavirus CV777 Scientific opinion on porcine epidemic diarrhea and emerging deltacoronavirus Complete genome sequence of a novel porcine epidemic diarrhea virus in south China Complete genome sequence of a porcine epidemic diarrhea S gene indel strain isolated in France Comparison of porcine epidemic diarrhoea viruses from Germany and the United States Serological evidence of infection with a coronavirus related to transmissible gastroenteritis virus and porcine epidemic diarrhea virus Genomic and evolutionary inferences between American and global strains of porcine epidemic diarrhea virus Pathology of US porcine epidemic diarrhea virus strain PC21A in gnotobiotic pigs Porcine epidemic diarrhea virus infection: etiology, epidemiology, pathogenesis and immunoprophylaxis Experimental infection of piglets with a korean strain of porcine epidemic diarrhoea virus Genome sequencing and analysis of a novelrecombinant porcine epidemic diarrhea virus strain from Henan Epidemic of diarrhoea caused by porcine epidemic diarrhoea virus in Italy Outbreak of porcine epidemic diarreha virus in Portugal Enterotoxigenic Eschirichia coli, rotavirus, porcine epidemic diarrhoea virus, adenovirus and calici-like virus in porcine postweaning diarrohea in Hungary Cell culture isolation and sequence analysis of genetically diverse US porcine epidemic diarrhea virus strains including a novel strain with a large deletion in the spike gene Letter to the editor. Pig Farm A new coronaviruslike particle associated with diarrhea in swine An immunoelectron and immunofluorescent study on the antigenic relationship between the coronavirus-like agent CV777 and several coronaviruses Porcine epidemic diarrhoea virus as a cause of persistent diarrhoea in a herd of breeding and finishing pigs Transmissible gastroenteritis and porcine epidemic diarrhoea in Britain Diagnosis and investigations on PED in northern Italy Differentiation betyween human coronaviruses NL63 and 229 E using a novel double-antibody sandwich enzyme-linked immunosorbent assay based on specific monoclonal antibodies Emergence of porcine epidemic diarrhea virus in southern Germany Emergence of porcine epidemic diarrhea virus in the United States: clinical signs, lesions, and viral genomic sequences Complete genome sequence of a porcine epidemic diarrhea virus from a novel outbreak in Belgium First case of Porcine Epidemic Diarrhea (PED) caused by a new variant of PED virus in The Netherlands Prevalence of infections with enzootic respiratory and enteric viruses in feeder pigs entering fattening units Distinct characteristics and complex evolution of PEDV strains, north America Coronavirus pathogenesis and the emerging pathogen Severe Acute Respiratory Syndrome coronavirus.


id: cord-297398-40bshqly
author: Dong, Wanyu
date: 2019-11-18
extension: .txt
mime: text/plain
words: 8655
sentence: 338
flesch: 47
cache: cache/cord-297398-40bshqly.txt
txt: txt/cord-297398-40bshqly.txt
title:
  Receptor tyrosine kinase inhibitors block proliferation of TGEV mainly through p38 mitogen-activated protein kinase pathways

summary:
  We also used another p38 inhibitor to validate its essential regulatory role in TGEV infection, and the results were consistent with those of BIRB796, which can significantly reduce TGEV replication (Fig. 5E and F) . TGEV infection induces high levels of p38 MAP kinase and JNK1 phosphorylation, both of which are required for TGEV replication.


id: cord-313126-7hrjzapj
author: Chen, Fangzhou
date: 2019-03-08
extension: .txt
mime: text/plain
words: 4470
sentence: 142
flesch: 34
cache: cache/cord-313126-7hrjzapj.txt
txt: txt/cord-313126-7hrjzapj.txt
title:
  Decline of transmissible gastroenteritis virus and its complex evolutionary relationship with porcine respiratory coronavirus in the United States

summary:
  Compared to the S gene of TGEV strains, the S gene of PRCV has 621-681 nt deletions at N-terminal, including in strains from Asia 26 . The traditional TGEV group consisted of TGEV strains isolated from the US, China, Japan, South Korea, England and Mexico.


id: cord-332358-0t4uxmj2
author: Lamphear, Barry J.
date: 2004-06-23
extension: .txt
mime: text/plain
words: 3131
sentence: 118
flesch: 41
cache: cache/cord-332358-0t4uxmj2.txt
txt: txt/cord-332358-0t4uxmj2.txt
title:
  A corn-based delivery system for animal vaccines: an oral transmissible gastroenteritis virus vaccine boosts lactogenic immunity in swine

summary:
  However, replacing subsequent injections of the modified live TGEV vaccine with oral corn vaccine boosters would clearly save considerable time and effort. Cereals are particularly well-suited expression vehicles since the expressed proteins can be stored at relatively high concentrations for extended periods of time without degradation and dry seed can be formulated into oral vaccines suitable for commercial applications.


id: cord-326349-59566vqe
author: Ding, Li
date: 2013-12-26
extension: .txt
mime: text/plain
words: 4896
sentence: 176
flesch: 51
cache: cache/cord-326349-59566vqe.txt
txt: txt/cord-326349-59566vqe.txt
title:
  Transmissible gastroenteritis virus infection induces cell cycle arrest at S and G2/M phases via p53-dependent pathway

summary:
  Since the proportion of cells in the S and G2/M phases was greater in TGEV infected cells compared to mock-infected cells, to investigate the effects of cell accumulation at S and G2/M phases on TGEV replication, synchronized cells in G2/M phase, G0/G1 phase, G1/S phase or asynchronous cells were simultaneously released from their different phase of cell cycle, and then either mock infected or infected with 0.5 MOI of TGEV, cell cycle profiles were determined by flow cytometry and TGEV gRNA and sgRNAs levels were determined by qRT-PCR at 18 h p.i. key: cord-326349-59566vqe authors: Ding, Li; Huang, Yong; Dai, Meiling; Zhao, Xiaomin; Du, Qian; Dong, Feng; Wang, Lili; Huo, RuiChao; Zhang, Wenlong; Xu, Xingang; Tong, Dewen title: Transmissible gastroenteritis virus infection induces cell cycle arrest at S and G2/M phases via p53-dependent pathway date: 2013-12-26 journal: Virus Res DOI: 10.1016/j.virusres.2013.09.036 sha: doc_id: 326349 cord_uid: 59566vqe p53 signaling pathway plays an important role in the regulation of cell cycle.


id: cord-349964-38rgcc5h
author: Pedersen, N. C.
title: Antigenic relationship of the feline infectious peritonitis virus to coronaviruses of other species
date: 1978
extension: .txt
mime: text/plain
words: 3024
sentence: 136
flesch: 47
cache: cache/cord-349964-38rgcc5h.txt
txt: txt/cord-349964-38rgcc5h.txt
summary:
  Zbl Antigenic relationship between human corona virus strain 0C 43 and hemagglutinating encephalomyelitis virus strain 67N of swine: antibody responses in human and animal sera I~ecovery in tracheal organ cultures of novel viruses from patients with respiratory disease Antigenic relationship among the coronaviruses of man and between human and animal coronaviruses Detection of eoronavirus infection of man by immunofluorescence Seroepidemiology of feline infectious peritonitis virus infections using transmissible gastroenteritis virus as antigen Rat corona virus (RCV) : a prevalent, naturally occurring pneumotropic virus of rats Serologic studies of naturally occurring feline infectious peritonitis Morphologic and physical characteristics of feline infectious peritonitis virus and its growth in autochthonous peritoneal ceil cultures Feline infectious peritonitis: something old, something new Characteristics of a coronavirus causing vomition and wasting in pigs Detection of transmissible gastroenteritis virus neutralizing antibody in cats Characterization of a calf diarrheal coronavirus Characterization of a calf diarrheal coronavirus Morphology-of transmissible gastroenteritis virus of pigs Morphogenesis of a virus in cats with experimental feline infectious peritonitis Untersuchungen fiber die Antigenverwandtschaft der Viren der Felinen infekti6ser Peritonitis und der transmissiblen Gastroenteritis des Sehweines Ultrastruetural evidence for the viral etiology of feline infectious peritonitis Received October 23, 1977 A possible antigenic relationship between feline infectious peritonitis virus (FIPV) and the transmissible gastroenteritis virus (TGEV) of swine has been recently reported (13, 19, 25) , which further supports the assumption t h a t


id: cord-341690-h8fqijk5
author: Hu, Weiwei
date: 2016-02-25
extension: .txt
mime: text/plain
words: 7551
sentence: 336
flesch: 50
cache: cache/cord-341690-h8fqijk5.txt
txt: txt/cord-341690-h8fqijk5.txt
title:
  The epidermal growth factor receptor regulates cofilin activity and promotes transmissible gastroenteritis virus entry into intestinal epithelial cells

summary:
  From 10 mpi to 60 mpi, the level of p-Akt increased in TGEV infected cells ( Figure 4A ). In contrast, the lipid rafts clustered in EGF treated or TGEV infected cells ( Figure 7A ).


id: cord-345651-admlzeu4
author: Wang, Gang
date: 2019-03-30
extension: .txt
mime: text/plain
words: 6244
sentence: 195
flesch: 40
cache: cache/cord-345651-admlzeu4.txt
txt: txt/cord-345651-admlzeu4.txt
title:
  The N-Terminal Domain of Spike Protein Is Not the Enteric Tropism Determinant for Transmissible Gastroenteritis Virus in Piglets

summary:
  The 43.5-kilodalton band of TGEV N protein ( Figure 2C ) and the marker mutation at position 4553 in the TGEV genome ( Figures 1B and 2D ) confirmed the recovery of the TGEV-GFP recombinant virus. The 43.5-kilodalton band of TGEV N protein ( Figure 2C ) and the marker mutation at position 4553 in the TGEV genome ( Figures 1B and 2D ) confirmed the recovery of the TGEV-GFP recombinant virus.


id: cord-300436-beb8k075
author: Zhang, Shuai
date: 2018-10-20
extension: .txt
mime: text/plain
words: 5728
sentence: 293
flesch: 50
cache: cache/cord-300436-beb8k075.txt
txt: txt/cord-300436-beb8k075.txt
title:
  Transferrin receptor 1 is a supplementary receptor that assists transmissible gastroenteritis virus entry into porcine intestinal epithelium

summary:
  Extracellular TfR1 interacts with TGEV S1 protein in vitro TGEV S1 protein binds to specific receptors on the membrane of susceptible cells The co-precipitation assay confirmed that the extracellular region of TfR1 interacts with TGEV S1 protein in vitro (Fig. 5b) .


id: cord-341860-a6yoz3w1
author: Zhao, Xiaomin
date: 2016-02-04
extension: .txt
mime: text/plain
words: 3288
sentence: 164
flesch: 51
cache: cache/cord-341860-a6yoz3w1.txt
txt: txt/cord-341860-a6yoz3w1.txt
title:
  miR-27b attenuates apoptosis induced by transmissible gastroenteritis virus (TGEV) infection via targeting runt-related transcription factor 1 (RUNX1)

summary:
  key: cord-341860-a6yoz3w1 authors: Zhao, Xiaomin; Song, Xiangjun; Bai, Xiaoyuan; Fei, Naijiao; Huang, Yong; Zhao, Zhimin; Du, Qian; Zhang, Hongling; Zhang, Liang; Tong, Dewen title: miR-27b attenuates apoptosis induced by transmissible gastroenteritis virus (TGEV) infection via targeting runt-related transcription factor 1 (RUNX1) date: 2016-02-04 journal: PeerJ DOI: 10.7717/peerj.1635 sha: doc_id: 341860 cord_uid: a6yoz3w1 Transmissible gastroenteritis virus (TGEV), belonging to the coronaviridae family, is the key cause of the fatal diarrhea of piglets and results in many pathological processes. Numerous experimental studies have demonstrated that miRNAs play important roles in cell apoptosis (Wilson & Doudna, 2013) .


id: cord-317496-6o2upns3
author: Pascual-Iglesias, Alejandro
date: 2019-07-25
extension: .txt
mime: text/plain
words: 7128
sentence: 310
flesch: 43
cache: cache/cord-317496-6o2upns3.txt
txt: txt/cord-317496-6o2upns3.txt
title:
  Recombinant Chimeric Transmissible Gastroenteritis Virus (TGEV)—Porcine Epidemic Diarrhea Virus (PEDV) Virus Provides Protection against Virulent PEDV

summary:
  The ELISA values of the sera were expressed as sample to positive ratio [SP-ratio = (OD of sample − OD of negative control)/(OD of positive control − OD of negative control)]. Heat-inactivated sera were incubated for 1 h at 37 • C in the presence of 100 pfus of PEDV virus in DMEM containing 5% FCS. These viruses required trypsin to efficiently infect Vero cells, and form syncytia, similarly to PEDV virus.


id: cord-339694-sp212tai
author: Jiang, Xinpeng
date: 2016-03-28
extension: .txt
mime: text/plain
words: 6830
sentence: 264
flesch: 37
cache: cache/cord-339694-sp212tai.txt
txt: txt/cord-339694-sp212tai.txt
title:
  A phase trial of the oral Lactobacillus casei vaccine polarizes Th2 cell immunity against transmissible gastroenteritis coronavirus infection

summary:
  This vaccine could induce TGEV antibody immune responses in both the humoral and mucosal immune systems. The pig model was developed to study intestinal mucosal immune responses (Ruan and Zhang 2013) .


id: cord-349800-s9w2yr08
author: Hohdatsu, T.
date: 1991
extension: .txt
mime: text/plain
words: 3080
sentence: 124
flesch: 52
cache: cache/cord-349800-s9w2yr08.txt
txt: txt/cord-349800-s9w2yr08.txt
title:
  Characterization of monoclonal antibodies against feline infectious peritonitis virus type II and antigenic relationship between feline, porcine, and canine coronaviruses

summary:
  key: cord-349800-s9w2yr08 authors: Hohdatsu, T.; Okada, S.; Koyama, H. title: Characterization of monoclonal antibodies against feline infectious peritonitis virus type II and antigenic relationship between feline, porcine, and canine coronaviruses date: 1991 journal: Arch Virol DOI: 10.1007/bf01310494 sha: doc_id: 349800 cord_uid: s9w2yr08 Seven monoclonal antibodies (MAbs) with neutralizing activity against feline infectious peritonitis virus (FIPV) strain 79-1149 (type II) were prepared. The second antigenic group consists of human respiratory coronavirus HCV-229E, transmissible gastroenteritis virus (TGEV) of swine, canine coronavirus (CCV), and feline infectious peritonitis virus (FIPV)


id: cord-337498-zp697h4k
author: Zhao, Xiaomin
date: 2017-12-07
extension: .txt
mime: text/plain
words: 4601
sentence: 217
flesch: 41
cache: cache/cord-337498-zp697h4k.txt
txt: txt/cord-337498-zp697h4k.txt
title:
  microRNA-4331 Promotes Transmissible Gastroenteritis Virus (TGEV)-induced Mitochondrial Damage Via Targeting RB1, Upregulating Interleukin-1 Receptor Accessory Protein (IL1RAP), and Activating p38 MAPK Pathway In Vitro

summary:
  IL1RAP Promotes TGEV-induced Mitochondrial Damage and Activates p38 MAPK Signaling-According proteomic analysis, overexpression of miR-4331 may lead to an increase of IL1RAP protein level. The results showed that pCI-neo-IL1RAP led to an increase IL1RAP at mRNA level (Fig. 8A ) and protein level (Fig. 8B) and siIL1RAP reduced mRNA level (Fig. 8A ) and protein level (Fig. 8B) .


id: cord-348896-a2mjj5dt
author: Abid, Nabil Ben Salem
date: 2010-12-28
extension: .txt
mime: text/plain
words: 3298
sentence: 153
flesch: 53
cache: cache/cord-348896-a2mjj5dt.txt
txt: txt/cord-348896-a2mjj5dt.txt
title:
  Molecular study of porcine transmissible gastroenteritis virus after serial animal passages revealed point mutations in S protein

summary:
  The nucleotide and the amino acid sequences of TGEV TMK22 strains were compared with the corresponding sequences of TGEV strains, available in GenBank database. Cell culture adapted TGEV TMK22 strain (the collection of microorganism strains of the Federal Governmental Institute, All-Russian Research Institute for Animal Health, FGI ARRIAH) was used in this study.


id: cord-355499-5vj3oasa
author: Song, Xiangjun
date: 2015-06-07
extension: .txt
mime: text/plain
words: 4237
sentence: 198
flesch: 47
cache: cache/cord-355499-5vj3oasa.txt
txt: txt/cord-355499-5vj3oasa.txt
title:
  Transmissible Gastroenteritis Virus (TGEV) Infection Alters the Expression of Cellular MicroRNA Species That Affect Transcription of TGEV Gene 7

summary:
  In conclusion, differentially expressed miR-4331 that is caused by TGEV infection can suppress transcription of TGEV gene 7 via targeting cellular CDCA7. Overall, we observed that TGEV infection caused the change of miRNA profile and miR-4331 suppressed transcription of TGEV gene 7 via directly targeting CDCA7.


id: cord-337645-t6py0oyw
author: Yin, Jiechao
date: 2010-10-14
extension: .txt
mime: text/plain
words: 4760
sentence: 189
flesch: 43
cache: cache/cord-337645-t6py0oyw.txt
txt: txt/cord-337645-t6py0oyw.txt
title:
  Cholesterol is important for a post-adsorption step in the entry process of transmissible gastroenteritis virus

summary:
  The role of lipid microdomains in virus biology Human coronavirus 229E binds to CD13 in rafts and enters the cell through caveolae Plasma membrane rafts play a critical role in HIV-1 assembly and release Association of human immunodeficiency virus type 1 gag with membrane does not require highly basic sequences in the nucleocapsid: use of a novel Gag multimerization assay Importance of cholesterol for infection of cells by transmissible gastroenteritis virus Cholesterol dependence of Pseudorabies Herpesvirus entry Transmissible gastroenteritis and porcine respiratory coronavirus Targeted recombination demonstrates that the spike gene of transmissible gastroenteritis coronavirus is a determinant of its enteric tropism and virulence Binding of transmissible gastroenteritis coronavirus to cell surface sialoglycoproteins Binding of transmissible gastroenteritis coronavirus to brush border membrane sialoglycoproteins Role of spike protein endodomains in regulating coronavirus entry Cholesterol, lipid rafts, and disease Lipid rafts and signal transduction How viruses enter animal cells Coronaviruses: structure and genome expression Role for influenza virus envelope cholesterol in virus entry and infection Mechanisms of transmissible gastroenteritis coronavirus neutralization Virus infection and lipid rafts Requirements for CEACAMs and cholesterol during murine coronavirus cell entry Tropism of human adenovirus type 5-based vectors in swine and their ability to protect against transmissible gastroenteritis coronavirus Immunogenicity of the S protein of transmissible gastroenteritis virus expressed in baculovirus National Natural Science Foundation of China (30700591) to J.Y. National Natural Science Foundation of China (30700590; 30972195), Though the effect of cholesterol depletion on virus infectivity cannot be explained by the lipid raft concept, it is evident that cholesterol is important for virus entry.


id: cord-329819-dpgexphf
author: Hu, Weiwei
title: Epidermal growth factor receptor is a co-factor for transmissible gastroenteritis virus entry
date: 2018-06-04
extension: .txt
mime: text/plain
words: 6789
sentence: 282
flesch: 48
cache: cache/cord-329819-dpgexphf.txt
txt: txt/cord-329819-dpgexphf.txt
summary:
  Cell membrane EGFR was analyzed by Westernblot using rabbit anti-EGFR pAb. For TGEV infected cells, TGEV particles bound with cells at 4°C.


id: cord-354904-7gq2e6f0
author: Staroverov, Sergey A.
title: Prospects for the use of spherical gold nanoparticles in immunization
date: 2018-11-06
extension: .txt
mime: text/plain
words: 5061
sentence: 226
flesch: 43
cache: cache/cord-354904-7gq2e6f0.txt
txt: txt/cord-354904-7gq2e6f0.txt
summary:
  The degradative processes observed in the animals immunized with TGEV antigen alone are evidence of weak resistance to pathogen attack. These results can be used to develop vaccines against this infection by employing TGEV antigen coupled to gold nanoparticles as a carrier.


id: cord-355991-4zu69e0y
author: Piñeyro, Pablo Enrique
date: 2018-09-24
extension: .txt
mime: text/plain
words: 3923
sentence: 186
flesch: 41
cache: cache/cord-355991-4zu69e0y.txt
txt: txt/cord-355991-4zu69e0y.txt
title:
  First retrospective studies with etiological confirmation of porcine transmissible gastroenteritis virus infection in Argentina

summary:
  The clinical diagnosis of TGEV infections in endemic regions is challenging due to the epidemiological distribution and coinfection with other enteric pathogens that mask the clinical presentation. Historically, TGEV infection has followed a seasonal pattern, becoming more prevalent during winter months perhaps due to increased viral survival in colder temperatures and with less exposure to sunlight.


id: cord-342289-zpstb7h9
author: Cui, Tingting
date: 2018-10-12
extension: .txt
mime: text/plain
words: 8383
sentence: 365
flesch: 46
cache: cache/cord-342289-zpstb7h9.txt
txt: txt/cord-342289-zpstb7h9.txt
title:
  Establishment of porcine enterocyte/myofibroblast co-cultures for the growth of porcine rota- and coronaviruses

summary:
  Epithelial cells co-cultured with myofibroblasts showed microvilli after 3 days of co-cultivation which is in accordance with the reported data that myofibroblasts not only support the growth of epithelial cells, but also stimulate the differentiation of epithelial cells 34 . The percentage of rotavirus infection in ileum epithelial cells increased to 4.8 ± 1.3% at 24 h p.i.


id: cord-346928-g1dqiki6
author: Costantini, V.
date: 2003-11-26
extension: .txt
mime: text/plain
words: 5903
sentence: 219
flesch: 51
cache: cache/cord-346928-g1dqiki6.txt
txt: txt/cord-346928-g1dqiki6.txt
title:
  Respiratory and fecal shedding of Porcine respiratory coronavirus (PRCV) in sentinel weaned pigs and sequence of the partial S-gene of the PRCV isolates

summary:
  In preliminary studies, inoculation of gnotobiotic pigs with each plaque-purified pair of the nasal and fecal PRCV isolates, revealed no clinical disease but different tropisms. In contrast TGEV strains have an intact S-gene.


id: cord-346872-k5d5793a
author: Yuan, Peng
date: 2018-09-03
extension: .txt
mime: text/plain
words: 5654
sentence: 235
flesch: 46
cache: cache/cord-346872-k5d5793a.txt
txt: txt/cord-346872-k5d5793a.txt
title:
  Three Main Inducers of Alphacoronavirus Infection of Enterocytes: Sialic Acid, Proteases, and Low pH

summary:
  Most α-CoVs use APN as cell entry receptor. TGEV and PEDV S proteins have many similarities in their secondary structure.


id: cord-302306-fudeixy2
author: Xu, Kui
date: 2020-09-02
extension: .txt
mime: text/plain
words: 9099
sentence: 327
flesch: 48
cache: cache/cord-302306-fudeixy2.txt
txt: txt/cord-302306-fudeixy2.txt
title:
  CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance

summary:
  In addition, with the exception of meat color score and iron content, no differences in the production performance, reproductive performance, or pork nutrient content were observed between DKO pigs and WT pigs. We used flow cytometry and western blotting for CD163, immunohistochemistry (IHC) and western blotting for pAPN, and confirmed that expression of both proteins was undetectable in DKO pigs but detectable in WT pigs of the same age and breed ( Figure 1E -G).


id: cord-316134-lkd2mj27
author: Sungsuwan, Suttipun
date: 2020-01-15
extension: .txt
mime: text/plain
words: 9264
sentence: 307
flesch: 41
cache: cache/cord-316134-lkd2mj27.txt
txt: txt/cord-316134-lkd2mj27.txt
title:
  Nucleocapsid proteins from other swine enteric coronaviruses differentially modulate PEDV replication

summary:
  No detectable fluorescence was observed from co-transfection with the empty pCAGGS vector, confirming the role of PEDV N protein during at least the first round of viral RNA transcription and viral protein translation (Fig. 7A ). Specifically, we asked if N proteins from TGEV or PDCoV can interact with PEDV N and possibly affect PEDV replication.


id: cord-328935-mn8r972x
author: Hodgins, Douglas C.
title: Mucosal Veterinary Vaccines: Comparative Vaccinology
date: 2015-03-13
extension: .txt
mime: text/plain
words: 16353
sentence: 541
flesch: 27
cache: cache/cord-328935-mn8r972x.txt
txt: txt/cord-328935-mn8r972x.txt
summary:
  The gnotobiotic piglet as a model for studies of disease pathogenesis and immunity to human rotaviruses Comparative studies of the pathogenesis, antibody immune responses, and homologous protection to porcine and human rotaviruses in gnotobiotic piglets Gut microbiota and probiotics in modulation of epithelium and gut-associated lymphoid tissue function Prevention of human rotavirus-induced diarrhea in gnotobiotic piglets using bovine antibody Influence of maternal antibodies on vaccine responses: inhibition of antibody but not T cell responses allows successful early prime-boost strategies in mice Canine parvovirus type 2 vaccine protects against virulent challenge with type 2c virus Boosting of secretory IgA antibody responses in man by parenteral cholera vaccination Cleavage of proteins of reproductive secretions by extracellular proteinases of Tritrichomonas foetus Differential production of proinflammatory cytokines: in vitro PRRSV and Mycoplasma hyopneumoniae co-infection model Veterinary Immunology, An Introduction Serum and intestinal isotype antibody responses and correlates of protective immunity to human rotavirus in a gnotobiotic pig model of disease Toll-like receptor 2 and 9 are expressed and functional in gut-associated lymphoid tissues of presuckling newborn swine Efficacy of a recombinant equine influenza vaccine against challenge with an American lineage H3N8 influenza virus responsible for the 2003 outbreak in the United Kingdom Efficacy of a cold-adapted, intranasal equine influenza vaccine: challenge trials Dendritic cell-targeted protein vaccines: a novel approach to induce T-cell immunity Failure of passive transfer in foals: incidence and outcome on four studs in New South Wales Protective immunity in macaques vaccinated with live attenuated, recombinant, and subunit measles vaccines in the presence of passively acquired antibodies Contribution of antibody-secreting cells induced in mucosal lymphoid tissues of pigs inoculated with respiratory or enteric strains of coronavirus to immunity against enteric coronavirus challenge Isotype-specific antibody-secreting cells to transmissible gastroenteritis virus and porcine respiratory coronavirus in gut-and bronchus-associated lymphoid tissues of suckling pigs Effects of various vaccination protocols on passive and active immunity to Pasteurella haemolytica and Haemophilus somnus in beef calves Development of an experimental inactivated PRRSV vaccine that induces virus-neutralizing antibodies Nanobodies ® : new ammunition to battle viruses Maternal antibodies against equine influenza virus in foals and their interference with vaccination Egg yolk IgY: protection against rotavirus induced diarrhea and modulatory effect on the systemic and mucosal antibody responses in newborn calves Cholera toxin improves the F4(K88)-specific immune response following oral immunization of pigs with recombinant FaeG A field trial to evaluate the efficacy of a combined rotaviruscoronavirus/Escherichia coli vaccine in dairy cattle Inactivated rotavirus vaccine induces protective immunity in gnotobiotic piglets Possible mechanisms of protection elicited by candidate rotavirus vaccines as determined with the adult mouse model Rotavirus vaccines: how they work or don't work Role of maternally derived circulating antibodies in protection of neonatal swine against porcine group Because PRRSV infection rapidly subverts the host immune responses, an effective adjuvant must overcome immunosuppression caused by vaccine virus and simultaneously potentiate virus-specific adaptive immunity.


id: cord-256444-grw5s2pf
author: Lai, Michael M.C.
title: The Molecular Biology of Coronaviruses
date: 1997-12-31
extension: .txt
mime: text/plain
words: 35274
sentence: 1243
flesch: 43
cache: cache/cord-256444-grw5s2pf.txt
txt: txt/cord-256444-grw5s2pf.txt
summary:
  This phenomenon is reminiscent of the RNA reassortment that occurs in RNA viruses with segmented RNA genomes. This structure places coronavirus in a unique position among RNA viruses because it takes on the characteristics of positive-, negative-and double-strand RNA viruses in morphology.


# ent

id: cord-263165-bv4dh9eu
sid: 260
eid: 1
type: PRODUCT
entity:
  un cas de pneumonie chez des bovins chliche beteiligung boviner coronaviren an respiratorischen krankheitsausbrfichen bei kfilbern und pathogenetisch-immunologische


id: cord-355991-4zu69e0y
sid: 159
eid: 1
type: ORG
entity:
  del virus de la diarrea epidémica porcina (pedv) en colombia detección de focos de gastroenteritis transmisible


