item: #1 of 153 id: cord-000324-to4g9he9 author: Spentzas, Thomas title: Ketamine inhibits tumor necrosis factor secretion by RAW264.7 murine macrophages stimulated with antibiotic-exposed strains of community-associated, methicillin-resistant Staphylococcus aureus date: 2011-01-25 words: 5305 flesch: 31 summary: In response to vancomycinexposed MW2, pre-incubation with ketamine reduced macrophage TNF secretion by approximately 29% (p < 0.05), i.e., from 33,085 ± 867 pg/mL to 23,347 ± 862 pg/mL. Pre-incubation with ketamine led to a similar reduction (25%; p < 0.05) in macrophage TNF secretion response after stimulation with vancomycinexposed LAC (from 28,365 ± 735 pg/mL to 21,432 ± 736 pg/mL). The NMDA inhibitors, MK-801 and APV, also suppressed macrophage TNF secretion after stimulation with either of the antibiotic-exposed CA-MRSA isolates, and the effect was not additive or synergistic with ketamine. keywords: daptomycin; ketamine; macrophage; mrsa; mw2; nmda; response; secretion; tnf; vancomycin cache: cord-000324-to4g9he9.txt plain text: cord-000324-to4g9he9.txt item: #2 of 153 id: cord-001039-qocuprwb author: Hayasaka, Daisuke title: TNF-α Acts as an Immunoregulator in the Mouse Brain by Reducing the Incidence of Severe Disease Following Japanese Encephalitis Virus Infection date: 2013-08-05 words: 8611 flesch: 46 summary: Stocks of JEV JaOArS982 and JaTH160 viruses were obtained from cell culture medium of baby hamster kidney (BHK) cells infected with viruses previously prepared in suckling mouse brains [49] . Fields virology Past, present, and future of Japanese encephalitis Natural Japanese encephalitis virus infection among humans in west and east Japan shows the need to continue a vaccination program Overview: Japanese encephalitis New initiatives for the control of Japanese encephalitis by vaccination: minutes of a WHO/CVI meeting Immunobiology of Japanese Encephalitis Virus Proinflammatory cytokines and chemokines in humans with Japanese encephalitis Correlation of tumor necrosis factor levels in the serum and cerebrospinal fluid with clinical outcome in Japanese encephalitis patients Flavivirus encephalitis: pathological aspects of mouse and other animal models A preliminary neuropathological study of Japanese encephalitis in humans and a mouse model Comparative study of mouse brains infected with Japanese encephalitis virus by intracerebral or intraperitoneal inoculation West Nile virus encephalitis: sequential histopathological and immunological events in a murine model of infection Pathogenesis of neurotropic arbovirus infections Flaviviruses. keywords: days; disease; encephalitis; figure; il-10; infected; infection; jaoars982; levels; mice; tnf; virus cache: cord-001039-qocuprwb.txt plain text: cord-001039-qocuprwb.txt item: #3 of 153 id: cord-001293-dfaxj3bv author: Cavaillon, Jean-Marc title: Is boosting the immune system in sepsis appropriate? date: 2014-03-24 words: 6247 flesch: 27 summary: The clinical observations used to argue that immunosuppression occurs in sepsis patients surviving the initial inflammatory cascade These are all organisms of normal virulence that cause nosocomial infections in sepsis patients because of the selection pressure of potent antibiotics and the presence of biofilm affected/colonized intravascular and urinary catheters. keywords: apoptosis; cells; cytokine; expression; immune; infection; mice; model; murine; patients; production; response; sepsis; tnf cache: cord-001293-dfaxj3bv.txt plain text: cord-001293-dfaxj3bv.txt item: #4 of 153 id: cord-002079-jne14jqf author: MacParland, Sonya A. title: Lipopolysaccharide and Tumor Necrosis Factor Alpha Inhibit Interferon Signaling in Hepatocytes by Increasing Ubiquitin-Like Protease 18 (USP18) Expression date: 2016-05-27 words: 7212 flesch: 38 summary: We suspect that whereas increased TNF-␣ does contribute to USP18 expression, there are other stimuli, for example, LPS and perhaps the recently described interferon-lambda 4 (56) , that also modulate hepatic USP18 expression. Hepatic ischemia/reperfusion injury led to an induction of USP18 expression in liver tissue and promotion of lymphocytic choriomeningitis replication. keywords: cells; expression; hepatic; hepatocytes; ifn-; infection; liver; lps; signaling; tnf-; usp18 cache: cord-002079-jne14jqf.txt plain text: cord-002079-jne14jqf.txt item: #5 of 153 id: cord-002119-kl431ev6 author: Garcia, Elisa title: Cytokine and Growth Factor Activation In Vivo and In Vitro after Spinal Cord Injury date: 2016-06-23 words: 13465 flesch: 36 summary: Current and future surgery strategies for spinal cord injuries Secondary injury mechanisms in traumatic spinal cord injury: a nugget of this multiply cascade Sensorimotor rehabilitation: at the crossroads of basic and clinical Translating mechanisms of neuroprotection, regeneration, and repair to treatment of spinal cord injury Degenerative and regenerative mechanisms governing spinal cord injury Molecular insights of the injured lesions of rat spinal cords: inflammation, apoptosis, and cell survival IL-1 gene deletion protects oligodendrocytes after spinal cord injury through upregulation of the survival factor Tox3 Neuroinflammation: a common pathway in CNS diseases as mediated at the blood-brain barrier Microarray analysis of expression of cell death-associated genes in rat spinal cord cells exposed to cyclic tensile stresses in vitro Cytokines and chemokines at the crossroads of neuroinflammation, neurodegeneration, and neuropathic pain Growth Factors Are Essential for Nervous System Development and Function Role of growth factors on periodontal repair Role of the TLR4 pathway in blood-spinal cord barrier dysfunction during the bimodal stage after ischemia/reperfusion injury in rats Effects of peripheral inflammation on the bloodspinal cord barrier The blood-spinal cord barrier: morphology and clinical implications The role of hemorrhage following spinal-cord injury Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury Blood-spinal cord barrier permeability in experimental spinal cord injury: dynamic contrast-enhanced MRI Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing Distribution and time course of protein extravasation in the rat spinal cord after contusive injury Cytokine transport across the injured blood-spinal cord barrier The dual role of tumor necrosis factor-alpha in the pathophysiology of spinal cord injury Receptor-mediated transport of LIF across blood-spinal cord barrier is upregulated after spinal cord injury Potent pro-inflammatory actions of leukemia inhibitory factor in the spinal cord of the adult mouse Leukemia inhibitory factor arrests oligodendrocyte death and demyelination in spinal cord injury Effects of MK801 on evoked potentials, spinal cord blood flow and cord edema in acute spinal cord injury in rats Pathophysiology of blood-spinal cord barrier in traumatic injury and repair Src family kinase inhibitor PP1 improves motor function by reducing edema after spinal cord contusion in rats Role of hypoxia-induced VEGF in blood-spinal cord barrier disruption in chronic spinal cord injury Alterations in tissue Mg ++ , Na + and spinal cord edema following impact trauma in rats Potassium and calcium changes in injured spinal cords Role of L-and N-type calcium channels in the pathophysiology of traumatic spinal cord white matter injury Radiopacity of intracerebral hemorrhage correlates with perihemorrhagic edema Selective vasopressin-1a receptor antagonist prevents brain edema, reduces astrocytic cell swelling and GFAP, V1aR and AQP4 expression after focal traumatic brain injury The neurobiology of glia in the context of water and ion homeostasis Involvement of aquaporin 4 in astrocyte function and neuropsychiatric disorders Aquaporin and brain diseases Regulators of synaptic transmission: roles in the pathogenesis and treatment of epilepsy Differential regulation of synaptic transmission by pre-and postsynaptic SK channels in the spinal locomotor network The N-type voltage-gated calcium channel: when a neuron reads a map Smallconductance Ca 2+ -activated K + channel type 2 (SK2) modulates hippocampal learning, memory, and synaptic plasticity Calcium signalling: dynamics, homeostasis and remodelling Local calcium signaling in neurons Remyelination after spinal cord injury: is it a target for repair? Calcium signalling in lymphocyte activation and disease Molecular mechanisms of calcium-dependent excitotoxicity Cellular defenses against excitotoxic insults Physiological and pathological functions of P2X7 receptor in the spinal cord Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury A reassessment of P2X7 receptor inhibition as a neuroprotective strategy in rat models of contusion injury Glutamate receptors in the mammalian central nervous system Glutamate transporters/ keywords: activation; cells; cord; cord injury; cytokines; expression; factor; glutamate; growth; il-1; injury; macrophages; microglia; molecules; receptor; response; role; sci; spinal; spinal cord; tnf cache: cord-002119-kl431ev6.txt plain text: cord-002119-kl431ev6.txt item: #6 of 153 id: cord-002209-xs6qigg4 author: Kıray, Hülya title: The multifaceted role of astrocytes in regulating myelination date: 2016-09-17 words: 7514 flesch: 15 summary: Attempts have also been made to define the astrocyte phenotype in more detail along this continuum (Liberto et al., 2004) . It is suggested that the increase in IL-1β levels at early stages of CNS pathology stimulates the induction of CNTF mRNA and protein in astrocytes (Stöckli et al., 1991; Guthrie et al., 1997; Dallner et al., 2002; Liberto et al., 2004) , a phenomenon which appears to be important for remyelination (Herx et al., 2000) . keywords: astrocytes; brain; cells; cns; cntf; cytokines; disease; et al; expression; factor; growth; injury; mice; myelination; oligodendrocyte; survival; tnf cache: cord-002209-xs6qigg4.txt plain text: cord-002209-xs6qigg4.txt item: #7 of 153 id: cord-002326-3qb1ym4w author: Yang, Runkuan title: Ethyl pyruvate is a novel anti-inflammatory agent to treat multiple inflammatory organ injuries date: 2016-12-03 words: 7637 flesch: 31 summary: EP treatment [EP source in this review was all from Sigma-Aldrich unless otherwise noted. SAP associated BT was reduced by 90% following EP treatment [6] breaking the link between BT and MODS. keywords: acute; brain; ethyl; hepatic; hmgb1; injury; liver; pyruvate; sap; treatment cache: cord-002326-3qb1ym4w.txt plain text: cord-002326-3qb1ym4w.txt item: #8 of 153 id: cord-003013-h8txbd3p author: Kim, Sena title: Differential Regulation of Toll-Like Receptor-Mediated Cytokine Production by Unfolded Protein Response date: 2018-04-24 words: 3730 flesch: 28 summary: Given that ER stress can restore cytokine production under endotoxin tolerance, it may be helpful to use ER stress induction to increase the cytokine production in the immune-depressed state. Studies have demonstrated that various metabolic syndromes are associated with chronic metabolic inflammation and impairment of ER function and established a link between inflammatory responses through the TLR signaling and ER stress response [12] keywords: activation; cytokine; gsk-3β; production; response; reticulum; signaling; stress; tlr cache: cord-003013-h8txbd3p.txt plain text: cord-003013-h8txbd3p.txt item: #9 of 153 id: cord-003686-1pfk4qve author: Kaneko, Naoe title: The role of interleukin-1 in general pathology date: 2019-06-06 words: 9513 flesch: 32 summary: Activated IL-1 is incapable of functioning until recognized by cell surface receptors. Gevokizumab is an anti-IL-1β monoclonal antibody, IgG2, which improved glucose control and β-cell function in a diet-induced-obesity mouse model [163] and in the presence of IL-1β-driven inflammatory diseases [164] . keywords: activation; anakinra; anti; canakinumab; cancer; cells; disease; human; il-1; inflammasome; inflammation; interleukin-1; nlrp3; patients; protein; receptor; response; study; syndrome; treatment; tumor cache: cord-003686-1pfk4qve.txt plain text: cord-003686-1pfk4qve.txt item: #10 of 153 id: cord-004879-pgyzluwp author: None title: Programmed cell death date: 1994 words: 81833 flesch: 47 summary: 8cl-2(z is a mitochondrial or perinuclear-associated oncoprotein that prolongs the life span of a variety of cell types by interfering with programmed cell death. Single and repetitive uptake and release of CPZ were measured in each cell type after individual exposure or exposure in any combination of cell types: In 2 hour competitive uptake studies fibreblasts reached 1.7 and 2.6 times the concentrations of C6-and ROC-cells, :respectively. keywords: acid; activation; activity; addition; adult; amino; analysis; animals; antibodies; binding; brain; calcium; cdna; cell lines; cells; changes; cloned; complex; concentrations; conditions; contrast; control; cultures; current; data; days; decrease; development; different; differentiation; dna; domain; early; effects; end; enzyme; epithelial; experiments; expression; extracts; factor; family; fold; form; formation; function; fusion; gene; gene expression; growth; homology; hormone; human; increase; induction; infected; inhibition; institut; interaction; intracellular; kda; kinase; levels; major; mammalian; mechanisms; medium; membrane; mice; molecular; mouse; mrna; muscle; mutant; nerve; neuronal; neurons; new; non; nuclear; nucleus; number; order; pathway; phosphorylation; play; positive; potential; presence; present; process; production; promoter; properties; protein; protein expression; rat; rate; rats; reaction; receptor; recombinant; recombination; region; regulation; release; replication; response; results; rna; role; sequence; signal; sites; species; specific; stage; stimulation; structure; studies; study; subunit; surface; synthesis; system; t cells; target; terminal; time; tissue; tnf; transcription; treatment; tumor; type; university; virus; vitro; vivo; yeast cache: cord-004879-pgyzluwp.txt plain text: cord-004879-pgyzluwp.txt item: #11 of 153 id: cord-004919-d7tilk8v author: Baker, Rahaf title: Macrophage activation syndrome in a patient with axial spondyloarthritis on adalimumab date: 2018-12-07 words: 1873 flesch: 37 summary: To the Editor: Macrophage activation syndrome (MAS) is a rare and potentially fatal condition characterized by excessive activation and uncontrolled proliferation of T lymphocytes and macrophages, leading to overwhelming systemic inflammation and cytokine release. These medications have been successful in treating some refractory cases of MAS, but their use may also rarely induce or aggravate autoimmune diseases, or trigger MAS in the setting of infection [1] . keywords: activation; macrophage; mas; patient; syndrome cache: cord-004919-d7tilk8v.txt plain text: cord-004919-d7tilk8v.txt item: #12 of 153 id: cord-005664-n4xv247l author: Plötz, Frans B. title: Mechanical ventilation alters the immune response in children without lung pathology date: 2002-01-15 words: 3295 flesch: 37 summary: The major finding of the present study is that exposing infants with normal lung function to 2 h of volatile anesthetics, mechanical ventilation, and cardiac catheterization is associated with remarkable changes in immune responses. key: cord-005664-n4xv247l authors: Plötz, Frans B.; Vreugdenhil, Harriet A.; Slutsky, Arthur S.; Zijlstra, Jitske; Heijnen, Cobi J.; van Vught, Hans title: Mechanical ventilation alters the immune response in children without lung pathology date: 2002-01-15 journal: Intensive Care Med DOI: 10.1007/s00134-002-1216-7 sha: doc_id: 5664 cord_uid: n4xv247l Objective: keywords: blood; lung; proinflammatory; response; tnf; ventilation cache: cord-005664-n4xv247l.txt plain text: cord-005664-n4xv247l.txt item: #13 of 153 id: cord-005814-ak5pq312 author: None title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 words: 179325 flesch: 51 summary: Leukemia inhibitory factor (LIF), a growth factor recently recognised as a polyfunctional cytokine integrated in cytokine networks was measured in unconcentrated BALF of patients from different patient groups. It is difficult to generalize on intensive care units as different patient groups are in different ICUs aud there are great changes from one hospital to another and from one country to another. keywords: activity; acute; administration; admission; adult patients; age; aim; airway; analysis; apache; application; ards patients; arf; arterial; artery; assess; average; baseline; blood; blood flow; blood pressure; blood volume; breathing; cardiac; care patients; care unit; cases; catheter; cerebral; changes; chest; children; clinical; compliance; complications; concentration; conclusions; conditions; constant; control group; control patients; copd patients; correlation; course; cpb; criteria; critical; cvp; daily; damage; data; days; death; death patients; decrease; diagnosis; difference; disease; dose; drugs; duration; dysfunction; effect; emergency; end; evaluation; exchange; factors; failure; failure patients; findings; flow; fluid; following; frequency; function; gas; gastric; general; good; group; group b; group ii; group patients; h20; head; heart; hemodynamic; hepatic; hospital; hours; hypertension; icp; icu patients; iii; ill; illness; improvement; incidence; increase; index; infection; influence; infusion; injury; intensive; introduction; intubation; lactate; left; levels; life; liver; lung; male; management; map; mean; measurements; median; medical; methods; min; minutes; mmhg; model; monitoring; mortality; mortality rate; muscle; myocardial; need; negative; new; non; normal; number; objectives; onset; operation; order; organ; outcome; output; oxygen; oxygenation; p =; p<0.05; pao2; parameters; patients; patients methods; pattern; peep; perfusion; period; phase; phi; plasma; population; position; postoperative; presence; present; pressure; pressure support; procedure; protocol; pts; pulmonary; rain; range; rate; rats; reduction; renal; resistance; respiratory; response; results; right; risk; risk patients; samples; saps; score; sepsis; septic; serum; severe; severity; shock; shock patients; signs; specific; standard; status; stay; studies; study; study group; study period; subjects; support; surgery patients; surgical; survival; survivors; syndrome; system; systemic; technique; temperature; test; therapeutic; therapy; time; tissue; total; tracheal; transplantation; trauma patients; treatment; tube; type; unit; university; use; values; variables; vascular; vein; venous; ventilation; ventricular; volume; weaning; years cache: cord-005814-ak5pq312.txt plain text: cord-005814-ak5pq312.txt item: #14 of 153 id: cord-005872-w1x1i0im author: Volk, T. title: Endothelium function in sepsis date: 2000 words: 8880 flesch: 21 summary: Endothelial cells lack CD14 receptors and LPS effects on endothelial cells generally require the presence of CD14 in the serum. Molecular analysis of a novel bidirectional pathway Two distinct phospholipases C of Listeria monocytogenes induce ceramide generation, nuclear factor-kappa acivation, and E-selectin expression in human endothelial cells Internalin B is essential for adhesion and mediates the invasion of Listeria monocytogenes into human endothelial cells Activation of human endothelial cells by viable or heat-killed gram-negative bacteria requires soluble CD14 Interaction of Neisseria maningitidis with the components of the blood-brain barrier correlates with an increased expression of PilC The Ndomain of the human CD66a adhesion molecule is a target for Opa proteins of Neisseria meningitidis and Neisseria gonorrhoeae Human microvascular endothelial tissue culture cell model for studying pathogenesis of Brazilian purpuric fever Pseudomonas aeruginosa selective adherence to and entry into human endothelial cells Endothelial function in sepsis 193 Cincomitant endosome-phagosome fusion and lysis of endosomal membranes account for Pseudomonas aeruginosa survival in human endothelial cells Endothelial cell GlcNAc beta 1-4GlcNAc epitopes for outer membrane protein A enhance traversal of Escherichia coli across the blood-brain barrier Escherichia coli invasion of brain microvascular endothelial cells in vitro and in vivo: molecular cloning and characterization of invasion gene ibe10 Characterization of a strain of Chlamydia pneumoniae isolated from a coronary atheroma by analysis of the omp1 gene and biological activity in human endothelial cells Chlamydia species infect human vascular endothelial cells and induce procoagulant activity Signal Transduction Pathways Activated in Endothelial Cells Following Infection with Chlamydia pneumoniae Bartonella (Rochalimaea) quintana endocarditis in three homeless men Bartonella quintana invades and multiplies within endothelial cells in vitro and in vivo and forms intracellular blebs Interaction of Bartonella henselae with endothelial cells results in bacterial aggregation on the cell surface and the subsequent engulfment and internalisation of the bacterial aggregate by a unique structure, the invasome NF-kappa B-dependent inhibition of apoptosis is essential for host cellsurvival during Rickettsia rickettsii infection Rickettsia conorii infection enhances vascular cell adhesion molecule-1-and intercellular adhesion molecule-1-dependent mononuclear cell adherence to endothelial cells IL-6 and IL-8 production from cultured human endothelial cells stimulated by infect on with Rickettsia conorii via a cell-associated IL-1 alpha-dependent pathway The role of CD14 in signaling mediated by outer membrane lipoproteins of Borrelia burgdorferi Integrins alpha(v)beta3 and alpha5beta1 mediate attachment of lyme disease spirochetes to human cells Different classes of proteoglycans contribute to the attachment of Borrelia burgdorferi to cultured endothelial and brain cells Borrelia burgdorferi upregulates the adhesion molecules E-selectin, P-selectin, ICAM-1 and VCAM-1 on mouse endothelioma cells in vitro Characterization of Plasmodium falciparum-infected erythrocyte and P-selectin interaction under flow conditions Intercellular adhesion molecule-1 and CD36 synergize to mediate adherence of Plasmodium falciparum-infected erythrocytes to cultured human microvascular endothelial cells PECAM-1/CD31, an endothelial receptor for binding Plasmodium falciparum-infected erythrocytes Candida albicans stimulates cytokine production and leukocyte adhesion molecule expression by endothelial cells Secreted aspartyl proteinases and interactions of Candida albicans with human endothelial cells Dengue virus infection of human endothelial cells leads to chemokine production, complement activation, and apoptosis Adhesion molecule expression and lymphocyte adhesion to cerebral endothelium: effects of measles virus and herpes simplex 1 virus Measles virus induction of human endothelial cell tissue factor procoagulant activity in vitro Effects of viral activation of the vessel wall on inflammation and thrombosis Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta3 integrins Ebola virus inhibits induction of genes by double-stranded RNA in endothelial cells Human endothelial cell activation and mediator release in response to the bacterial exotoxins Escherichia coli hemolysin and staphylococcal alpha-toxin Infection by verocytotoxin-producing Escherichia coli Alpha toxin from Clostridium perfringens induces proinflammatory changes in endothelial cells Brain capillary endothelial cells express MBEC1, a protein that is related to the Clostridium perfringens enterotoxin receptors Phospholipase C and perfringolysin O from Clostridium perfringens upregulate endothelial cellleukocyte adherence molecule 1 and intercellular leukocyte adherence molecule 1 expression and induce interleukin-8 synthesis in cultured human umbilical vein endothelial cells Glucosylation of small GTP-binding Rho proteins disrupts endothelial barrier function Pasteurella multocida toxin increases endothelial permeability via Rho kinase and myosin light chain phosphatase Evidence for a structural motif in toxins and interleukin-2 that may be responsible for binding to endothelial cells and initiating vascular leak syndrome The listerial exotoxins listeriolysin and phosphatidylinositol-specific phospholipase C synergize to elicit endothelial cell phosphoinositide metabolism Lipoteichoic acid-induced neutrophil adhesion via E-selectin to human umbilical vein endothelial cells (HUVECs) Endothelial and epithelial cells do not respond to complexes of peptidoglycan with soluble CD14 but are activated indirectly by peptidoglycan-induced tumor necrosis factor-alpha and interleukin-1 from monocytes Cytokines and endothelial cell biology Cytokine regulation of endothelial cell function: from molecular level to he bedside Pseudomonas siderophore pyochelin enhances neutrophil-mediated endothelial cell injury Superoxide dismutase-dependent, catalase-sensitive peroxides in human endothelial cells infected by Rickettsia rickettsii Superoxide release from interleukin-1B-stimulated human vascular cells: in situ electrochemical measuremeut Lipopolysaccharide enhances oxidative modification of low density lipoprotein by copper ions, endothelial and smooth muscle cells E-selectin expression in human endothelial cells by TNF-alpha-induced oxidant generation and NF-kappaB activation Superoxide responses of endothelial cells to C5a and TNF-alpha: divergent signal transduction pathways Lactosylceramide mediates tumor necrosis factor-alpha induced intercellular adhesion molecule-1 (ICAM-1) expression and the adhesion of neutrophil in human umbilical vein endothelial cells Effect of antioxidants on lipopolysaccharide-stimulated induction of mangano superoxide dismutase mRNA in bovine pulmonary artery endothelial cells Ambient but not incremental oxidant generation effects intercellular adhesion molecule 1 induction by tumour necrosis factor alpha in endothelium ICAM-1 and VCAM-1 expression induced by TNF-alpha are inhibited by a glutathione peroxidase mimic Glutathione peroxidase mimics prevent TNFalpha-and neutrophilinduced endothelial alterations Pore-forming bacterial toxins potently induce release of nitric oxide in porcine endothelial cells Cytokine-induced, nitric oxide-dependent, intracellular antirickettsial activity of mouse endothelial cells Endothelial cells are activated by cytokine treatment to kill an intravascular parasite, Schistosoma mansoni, through the production of nitric oxide Escherichia coli endotoxin inhibits agonistmediated cytosolic Ca2 + mobilization and nitric oxide biosynthesis in cultured endothelial cells Expressional control of the constitutive isoforms of nitric oxide synthase (NOS I and NOS III) Inducible nitric oxide: an autoregulatory feedback inhibitor of vascular inflammation Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide Nitric oxide donor prevents hydrogen peroxide-mediated endothelial cell injury Nitric oxide attenuates hydrogen peroxide-mediated injury to porcine pulmonary artery endothelial cells Protective effects of tetrahydrobiopterin against nitric oxide-induced endothelial cell death Endothelial damage induced by nitric oxide: synergism with reactive oxygen species Hydroxyl radical formation resulting from the interaction of nitric oxide and hydrogen peroxide Halliwell B van d V. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothelial cells Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation Lipopolysaccharide induces the antiapoptotic molecules, A1 and A20, in microvascular endothelial cells Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases Oxidant-sensitive and phosphorylation-dependent activation of NF-kappa B and AP-1 in endothelial cells Endothelial activation by hydrogen peroxide. keywords: activation; adhesion; alpha; cells; endothelial; expression; factor; function; human; infection; lps; microvascular; nitric; oxide; patients; permeability; production; relaxation; selectin; sepsis; shock; tnf cache: cord-005872-w1x1i0im.txt plain text: cord-005872-w1x1i0im.txt item: #15 of 153 id: cord-005983-2ascbu62 author: Eigler, A. title: Suppression der Synthese des Tumornekrosefaktors date: 2001 words: 2389 flesch: 32 summary: [21] von TNF während der Gabe von Anti-CD3-Antikörpern schwächt deren Nebenwirkungen ab. Eine Vielzahl körpereigener Mediatoren und exogener Wirkstoffe wurden identifiziert, die die Synthese von TNF in therapeutischen Dosierungen hemmen. keywords: bei; camp; der; des; die; eine; factor; hemmung; human; mit; necrosis; rolipram; synthese; tnf; tumor; und; von; werden; wurde; zur cache: cord-005983-2ascbu62.txt plain text: cord-005983-2ascbu62.txt item: #16 of 153 id: cord-006230-xta38e7j author: None title: Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e.V. date: 2012-02-22 words: 136000 flesch: 40 summary: In in-vitro studies on rat and canine mast cells and human mast cell leukemia cells HMC1.2 BZ at micromolar concentrations inhibited mediator release which appeared to be related to an inhibition of the intracellular cAMP pathway. Previous work showed that mouse cells lacking the immediate-early gene c-fos are hypersensitive to ultraviolet (UVC) light. keywords: acid; activation; activity; acute; addition; adducts; agonist; aim; analysis; animals; anti; apoptosis; approach; assay; assessment; binding; blood; brain; calcium; camp; cancer; cancer cells; cardiac; cell line; cells; cellular; cgmp; changes; channels; chronic; clinical; complex; compounds; concentration; conclusion; conditions; contrast; control; current; damage; data; days; death; decrease; deficient; development; differences; differentiation; disease; dna; dose; drug; e.g.; effects; endothelial; enzyme; evidence; experiments; exposure; expression; factor; failure; family; fibroblasts; findings; fold; food; formation; function; für; g protein; gene; gene expression; germany; glucose; growth; health; heart; human; hypertrophy; increase; induction; inflammation; inhibition; inhibitors; institut; insulin; interaction; intracellular; kidney; kinase; leads; levels; like; line; liver; loss; low; lung; macrophages; mechanisms; membrane; methods; mice; model; mouse; mrna; muscle cells; mutations; nanoparticles; ndpk; non; novel; number; pain; pathway; patients; pcr; pharmakologie; phosphorylation; plasma; potential; presence; present; pressure; primary; processes; production; products; proliferation; promoter; properties; protein; protein expression; pulmonary; rats; receptor; reduced; regulation; release; response; results; risk; rkip; role; ros; samples; selective; signaling; site; skin; smooth; specific; stimulation; stress; studies; study; substances; subunits; synthesis; system; t cells; target; test; tested; therapy; time; tissue; toxicity; toxikologie; toxin; transcription; transport; treatment; tumor; tumor cells; type; universität; uptake; values; vascular; vitro; vivo; water cache: cord-006230-xta38e7j.txt plain text: cord-006230-xta38e7j.txt item: #17 of 153 id: cord-006444-eq56zhtd author: None title: Abstracts of oral presentations and posters date: 1993 words: 40759 flesch: 49 summary: The shortened NTT was also reflected by a decreased proportion of marrow cells in the post mitotic pool (metas, bands and PMNs) and apparently lengthened blood The application of r-canine G-CSF enhanced the recovery of granulocytes but led to graft failure in dogs receiving a low number of marrow cells. keywords: activity; administration; blood; bone; cells; chemotherapy; clinical; colony; combination; control; csf; cytokines; days; disease; dose; effects; expression; factor; group; growth; human; ifn; il-2; il-3; il-6; increase; levels; marrow; median; neutropenia; non; normal; number; patients; phase; production; proliferation; protein; pts; response; results; rhg; role; serum; stem; stimulation; studies; study; tnf; treatment; tumor; vitro cache: cord-006444-eq56zhtd.txt plain text: cord-006444-eq56zhtd.txt item: #18 of 153 id: cord-006518-al94gxjw author: Calder, Philip C. title: n−3 Fatty acids, inflammation, and immunity— Relevance to postsurgical and critically III patients date: 2004 words: 10067 flesch: 25 summary: Fish oil did not decrease bacterial translocation across the gut, and so the authors concluded that fish oil must have improved bacterial killing. Comparison Between Young and Older Women The Effect on Human Tumor Necrosis Factor a and Fatty Acids from Vegetable Oil or Fish Oil Prostaglandin E2 Production and T-Cell Function After Fish-Oil Supplementation: Response to Antioxidant Co-supplementation Effects of Dietary Enrichment with Eicosapentaenoic Acid and Docosahexaenoic Acid on In Vitro Neutrophil and Monocyte Leukotriene Generation and Neutrophil Function Dietary ω-3 Polyunsaturated Fatty Acids Inhibit Phosphoinositide Formation and Chemotaxis in Neutrophils n-3 Fatty Acids and Cysteinyl-Leukotriene Formation in Humans in vitro, ex vivo and in vivo Manipulation of Platelet Aggregation by Prostaglandins and Their Fatty Acid Precursors: Pharmacological Basis for a Therapeutic Approach Interaction Between Peroxidase and Cyclooxygenase Activities in Prostaglandin-Endoperoxide Synthase Eicosapentaenoic Acid Inhibits Prostaglandin D2 Generation by Inhibiting Cyclo-oxygenase-2 in Cultured Human Mast Cells Effects of Exogenous Arachidonic, Eicosapentaenoic, and Docosahexaenoic Acids on the Generation of 5-Lipoxygenase Pathway Products by Ionophore-Activated Human Neutrophils Effect of Docosahexaenoic Acid (DHA) on Arachidonic Acid Metabolism and Platelet Function Docosahexaenoic Acid is a Strong Inhibitor of Prostaglandin but Not Leukotriene Biosynthesis N-3 Fatty Acids Specifically Modulate Catabolic Factors Involved in Articular Cartilage Degradation Pathologic Indicators of Degradation and Inflammation in Human Osteoarthritic Cartilage are Abrogated by Exposure to N-3 Fatty Acids Fatty Acid Substrate Specificities of Human Prostaglandin-Endoperoxide H Synthase-1 and -2 Structure of Eicosapentaenoic and Linoleic Acids in the Cyclooxygenase Site of Prostaglandin Endoperoxidase H Synthase-1 Separation and Quantification of PGE3 Following Derivatization with Panacyl Bromide by High Pressure Liquid Chromatography with Fluorometric Detection Human Neutrophil Chemotactic and Degranulating Activities of Leukotriene B5 (LTB5) Derived from Eicosapentaenoic Acid Characterization and Biologic Properties of 5,12-Dihydroxy Derivatives of Eicosapentaenoic Acid, Including Leukotriene-B5 and the Double Lipoxygenase Product Synthesis of 4-Series and 5-Series Leukotrienes in the Lung Microvasculature Challenged with Escherichia coli Hemolysin: Critical Dependence on Exogenous Free Fatty Acid Supply Impact of Arachidonic Acid Versus Eicosapentaenoic Acid on Exotoxin-Induced Lung Vascular Leakage-Relation to 4-Series Versus 5-Series Leukotriene Generation Alteration of n-3 Fatty Acid Composition in Lung Tissue After Short-Term Infusion of Fish Oil Emulsion Attenuates Inflammatory Vascular Reaction Anti-Inflammatory Lipid Signals Generated From Dietary n-3 Fatty Acids via Cyclooxygenase-2 and Transcellular Processing: keywords: acid; cells; chain; effects; expression; fatty; fish; human; n-3; oil; patients; production; response; sepsis; studies; tnf cache: cord-006518-al94gxjw.txt plain text: cord-006518-al94gxjw.txt item: #19 of 153 id: cord-006610-me8rhkcg author: Nör, Jacques E. title: Role of endothelial cell survival and death signals in angiogenesis date: 1999 words: 9996 flesch: 28 summary: Another study has identi®ed the activation of the phosphatidylcholine-speci®c phospholipase C and production of diacylglycerol (DAG) as essential components of integrin mediated survival signals in endothelial cells [183] . Exposure of human endothelial cells to gamma interferon (IFN-gamma) was shown to inhibit the a V b 3 -mediated survival pathway and to induce endothelial cell apoptosis in vitro When this positive`survival' signal is eliminated endothelial cells become more responsive to inhibitors of angiogenesis leading to endothelial cell apoptosis, vessel disassembly, and tumor regression ( Figure 4 ). keywords: angiogenesis; apoptosis; cell; cell apoptosis; cell survival; death; endothelial; expression; factor; growth; growth factor; role; survival; tnf; tumor; vascular; vegf; vitro cache: cord-006610-me8rhkcg.txt plain text: cord-006610-me8rhkcg.txt item: #20 of 153 id: cord-006770-m5wqk6rh author: Rook, Graham A. W. title: Evaluation of TNF as antiviral, antibacterial and antiparasitic agent date: 1991 words: 4567 flesch: 41 summary: Moreover, the free virus is able to trigger TNF release from uninfected monocytes by cross-linking membrane CD4 This has given rise to suggestions for the treatment of Gram-negative shock, severe malaria, etc., with regimes aimed at reducing TNF levels, either directly by antibodies or inhibitors, or indirectly by vaccine-induced immunity against the triggering molecules [24] . keywords: cells; effect; factor; human; infection; mice; necrosis; tnf; tumour; virus cache: cord-006770-m5wqk6rh.txt plain text: cord-006770-m5wqk6rh.txt item: #21 of 153 id: cord-006828-i88on326 author: None title: Abstracts DGRh-Kongress 2013 date: 2013-09-15 words: 30854 flesch: 47 summary: Es zeigen sich keine signifikanten Unterschiede in der Krankheitsaktivität der beiden Gruppen (vor Einleitung der ADA-Therapie nach DMARD-und nach anti-TNF-Versagen). key: cord-006828-i88on326 authors: nan title: Abstracts DGRh-Kongress 2013 date: 2013-09-15 journal: Z Rheumatol DOI: 10.1007/s00393-013-1255-1 sha: doc_id: 6828 cord_uid: i88on326 nan im Namen der DGRh, der DGORh und der GKJR begrüßen wir Sie ganz herzlich zu unserem diesjährigen Kongress Visualisierung therapeutischer Effekte von Vasodilatantien beim sekundären Raynaud-Syndrom mittels fluoreszenzoptischer Bildgebung DI.14 Stellenwert der Gelenksonographie bezüglich Diagnose, Behandlung und Therapiekontrolle der Bursitis intermetatarsalis -einer häufig übersehenen Differenzialdiagnose. keywords: abatacept; active; activity; adiponectin; als; analysis; anti; antibodies; arthritis; auch; auf; b cells; background; baseline; bei; bei der; blood; bone; cd4; cells; changes; conclusion; das; das28; data; days; den; der; des; die; disease; dose; effects; eine; elisa; expression; für; human; hypoxia; ifn; igg; il-6; immune; inflammation; ist; joint; levels; lupus; marrow; methods; mice; mit; monocytes; months; mri; mtx; nach; new; non; patienten; patients; plasma; plasma cells; positive; production; progression; ra patients; receptor; remission; response; results; rheumatoid; role; serum; sich; sle; sle patients; sowie; stimulation; study; synovial; t cells; therapie; therapy; time; tnf; treatment; und; von; week; werden; wurde; years; zur cache: cord-006828-i88on326.txt plain text: cord-006828-i88on326.txt item: #22 of 153 id: cord-007613-g4s0v8ra author: Rimstad, Espen title: Cloning, expression and characterization of biologically active feline tumour necrosis factor-α date: 2000-03-10 words: 4671 flesch: 47 summary: Polyclonal rabbit anti-murine TNF-a (Genzyme, Cambridge, MA) and monoclonal anti-human TNF-a (Biosource International, Camarillo, CA) were used. Three primers, making up two pairs P 1 /P3 and P2/P3, were constructed from a previously published sequence of feline TNF-a (McGraw et al., 1990) : keywords: cats; cells; expression; factor; feline; gst; human; necrosis; protein; rftnf; tnf cache: cord-007613-g4s0v8ra.txt plain text: cord-007613-g4s0v8ra.txt item: #23 of 153 id: cord-007621-rapinodd author: Vidovic, Maria title: Induction and regulation of class II major histocompatibility complex mRNA expression in astrocytes by interferon-γ and tumor necrosis factor-α date: 2002-11-13 words: 6691 flesch: 45 summary: Furthermore, astrocyte class II mRNA expression was inhibited when cycloheximide (CHX) was added together with IFN-γ or IFN-γ/TNF-α, and when CHX was added up to 4 h after treatment with IFN-γ or IFN-γ/TNF-α. These results indicate that astrocyte class II mRNA expression is mediated by newly synthesized proteins induced by IFN-γ and/or IFN-γ/TNF-α. keywords: astrocytes; cells; class; class ii; et al; expression; ifn; mhc; mrna; tnf cache: cord-007621-rapinodd.txt plain text: cord-007621-rapinodd.txt item: #24 of 153 id: cord-007858-1ijxilpb author: Xu, G.L. title: Attenuation of acute lung injury in mice by oxymatrine is associated with inhibition of phosphorylated p38 mitogen-activated protein kinase date: 2005-04-08 words: 4057 flesch: 48 summary: In the present study, our data revealed that serum TNF-␣ level was higher in oleic acid group than that in control group. Representative photomicrographs showing: epithelial cell swelling (endoplasmic reticulum dilation and mitochondria swelling) (B), the existence of red blood cells (C) and inflammatory cells (D) in alveolar spaces were observed in oleic acid group. keywords: acid; ali; group; injury; kinase; lung; oleic; oxymatrine; p38 cache: cord-007858-1ijxilpb.txt plain text: cord-007858-1ijxilpb.txt item: #25 of 153 id: cord-009326-dvhkk405 author: Lee, Jae Min title: Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation date: 2020-03-14 words: 6468 flesch: 47 summary: A previous study has demonstrated that pro-inflammatory gene expression is elevated in adipose tissue in the early onset of obesity, but in other tissues, such as liver and skeletal muscle, there is no differences in the expression of inflammatory gene expressions [3] . Trends Endocrino AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis Singh, I. 5-Aminoimidazole-4-Carboxamide Ribonucleoside: A Novel Immunomodulator with Therapeutic Efficacy in Experimental Autoimmune Encephalomyelitis AMPK Agonists Ameliorate Sodium and Fluid Transport and Inflammation in Cystic Fibrosis Airway Epithelial Cells Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1 AMP-Activated Protein Kinase α1 Protects Against Diet-Induced Insulin Resistance and Obesity Antityrosinase and antioxidant effects of ent-kaurane diterpenes from leaves of Broussonetia papyrifera Antioxidant lignans from the fruits of Broussonetia papyrifera Comparison with various parts of Broussonetia papyrifera as to the antinociceptive and anti-inflammatory activities in rodents Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki Kazinol B from Broussonetia kazinoki improves insulin sensitivity via Akt and AMPK activation in 3T3-L1 adipocytes Anti-inflammatory flavonoids from root bark of Broussonetia papyrifera in LPS-stimulated RAW264.7 cells Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors Polyphenols from Broussonetia papyrifera displaying potent alpha-glucosidase inhibition Inflammation, stress, and diabetes Five New Diprenylated Flavonols from the Leaves of Broussonetia kazinoki keywords: adipocytes; adipose; ampk; expression; figure; inflammation; phosphorylation; pre; tissue; tnf cache: cord-009326-dvhkk405.txt plain text: cord-009326-dvhkk405.txt item: #26 of 153 id: cord-013183-t25gecuw author: Beloumi, Dhekra title: Inflammatory Correlated Response in Two Lines of Rabbit Selected Divergently for Litter Size Environmental Variability date: 2020-09-01 words: 3578 flesch: 44 summary: The high line had also higher concentrations of bilirubin, cholesterol, gamma-glutamyl transferase (GGT) and alkaline phosphatase (ALP) compared to the low line (difference between lines were +0.08 µmol/L, +0.14 µmol/L, +0.35 U/L and +2.4 U/L, respectively). Marginal posterior distributions of the differences between lines were computed with the program Rabbit, developed by the Institute for Animal Science and Technology (Valencia, Spain). keywords: concentration; diseases; inflammation; line; litter; rabbits; response; selection; size cache: cord-013183-t25gecuw.txt plain text: cord-013183-t25gecuw.txt item: #27 of 153 id: cord-013366-sbdtpsz6 author: Ramírez-Pérez, Sergio title: Downregulation of Inflammatory Cytokine Release from IL-1β and LPS-Stimulated PBMC Orchestrated by ST2825, a MyD88 Dimerisation Inhibitor date: 2020-09-21 words: 5782 flesch: 37 summary: The interleukin (IL)-1 cytokine family-Balance between agonists and antagonists in inflammatory diseases Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway Peptide-mediated interference of TIR domain dimerisation in MyD88 inhibits interleukin-1-dependent activation of NF-{kappa}B IRAK1 and TRAF6 knockdown in human chondrocytes inhibits interleukin-1-induced matrix metalloproteinase-13 gene expression and promoter activity by impairing MAP kinase activation Disrupting myddosome assembly in diffuse large B-cell lymphoma cells using the MYD88 dimerisation inhibitor ST2825 Neuron-specific effects of interleukin-1β are mediated by a novel isoform of the IL-1 receptor accessory protein A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1 The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade Interleukin-1 family cytokines and mast cells: Activation and inhibition CAR-T cell therapy causes inflammation by IL-1 which activates inflammatory cytokine mast cells: Anti-inflammatory role of IL-37 Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): Anti-inflammatory strategies This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution The authors declare no conflict of interest. The IL-1β activity implicates binding between this cytokine and the IL-1R type I (IL-1RI), this binding triggers the interaction of Toll-IL-1-receptor (TIR) domains followed by MyD88 recruitment and downstream signalling cascades, which converge in the activation of several transcription factors and pro-inflammatory cytokine production [2, 6] . keywords: activation; cytokines; il-1β; lps; myd88; pbmc; production; signalling; st2825 cache: cord-013366-sbdtpsz6.txt plain text: cord-013366-sbdtpsz6.txt item: #28 of 153 id: cord-013803-d1sbfibq author: Abu El-Asrar, Ahmed M. title: Soluble cytokine receptor levels in aqueous humour of patients with specific autoimmune uveitic entities: sCD30 is a biomarker of granulomatous uveitis date: 2019-12-05 words: 4691 flesch: 38 summary: key: cord-013803-d1sbfibq authors: Abu El-Asrar, Ahmed M.; Berghmans, Nele; Al-Obeidan, Saleh A.; Gikandi, Priscilla W.; Opdenakker, Ghislain; Van Damme, Jo; Struyf, Sofie title: Soluble cytokine receptor levels in aqueous humour of patients with specific autoimmune uveitic entities: sCD30 is a biomarker of granulomatous uveitis date: 2019-12-05 journal: Eye (Lond) DOI: 10.1038/s41433-019-0693-7 sha: doc_id: 13803 cord_uid: d1sbfibq PURPOSE: Soluble cytokine receptors are potential biomarkers for immune activation and have a promising potential as immunotherapeutic agents. keywords: cytokine; disease; levels; patients; receptors; soluble; tnf; uveitis cache: cord-013803-d1sbfibq.txt plain text: cord-013803-d1sbfibq.txt item: #29 of 153 id: cord-015021-pol2qm74 author: None title: Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date: 1994 words: 162543 flesch: 45 summary: Ever since we know the role of endotoxins in the pathophysiology of sepsis, antibodies against the S-and R-LPS have also been detected in sepsis patients. In sepsis patients, the CD]4+/CD16+ cells can become a major population with more than 50% of all monocytes in 3 of 18 patients and with more than 500 cells/mm 3 in 4 of 18 cases. keywords: acid; activation; activity; acute; addition; adhesion; administration; aim; analysis; animals; anti; antibodies; antibody; ards; arterial; bacteria; binding; blood; blood cells; blood levels; blood samples; body; burn; capacity; cardiac; cause; cd14; cells; cellular; challenge; changes; circulating; clinical; clp; complement; complications; concentrations; conclusion; conditions; contrast; control; control group; control patients; correlation; course; csf; cultured; cytokine levels; cytokine production; cytokines; damage; data; days; death; decrease; development; differences; disease; dose; dysfunction; effect; elevated; elisa; endothelial; endotoxin; endotoxin levels; evidence; experimental; expression; factor; failure; flow; following; formation; function; gene; gram; group; growth; gut; hepatic; high; host; hours; hrs; human; il-1; il-6; il-6 levels; il-8; ill; immune; increased; induction; infection; inflammation; inflammatory; infusion; inhibitor; injury; ischemia; leukocytes; levels; lipid; liver; lps; lung; lymphocytes; macrophages; mean; mechanisms; mediators; membrane; methods; mice; model; mof; molecules; monoclonal; monocytes; mortality; multiple; necrosis; negative; neutrophils; new; non; normal; number; operation; organ; organ failure; organ injury; outcome; oxygen; p<0.05; parameters; patients; period; peritoneal; phase; placebo; plasma; plasma levels; plasma tnf; play; pmn; positive; post; postoperative; potential; presence; present; pressure; process; production; protein; pulmonary; rate; rats; receptor; reduced; related; release; reperfusion; response; results; risk; role; saline; samples; score; sepsis; sepsis patients; septic; serum; serum levels; severity; sham; shock; sirs; soluble; specific; state; stimulation; studies; study; surface; surgery; survival; syndrome; synthesis; system; systemic; t cells; test; therapeutic; therapy; time; tissue; tnf; tnf levels; tnf production; tnf release; total; trauma patients; treated; treatment; tumor; type; use; values; vascular; vitro; vivo; wound cache: cord-015021-pol2qm74.txt plain text: cord-015021-pol2qm74.txt item: #30 of 153 id: cord-015147-h0o0yqv8 author: None title: Oral Communications and Posters date: 2014-09-12 words: 73903 flesch: 39 summary: After 3 months of exposures, inflammatory cells in bronchoalveolar lavage fluid were increased in both the HCR-and LCR-smokeexposed(SE) animals compared to air-exposed controls (p<0.001); however there was a 2-3-fold increase in the number of neutrophils and lymphocytes in the LCR-over the HCR-SE group (p<0.001).Histopathology revealed there was greater inflammation and lung damage present in the LCR-versus HCR-SE group (p<0.05). This causes the symptoms of the early phase of AI and the onset of the late phase characterized by the penetration in the inflamed tissue of inflammatory cells, notably the eosinophils. keywords: activation; activity; acute; addition; adhesion; administration; aim; alpha; analysis; animals; anti; antibodies; antibody; arthritis; associated; beta; binding; blood; bone; cancer; cartilage; cells; chronic; complex; conditions; control; cox-2; cytokines; data; day; days; development; disease; dose; effect; expression; factor; function; gene; group; hours; human; il-1b; il-6; immune; increase; induction; inflammation; inflammatory; inhibited; inhibition; inhibitors; injection; injury; joint; kinase; leukocyte; levels; lps; lung; macrophages; mechanisms; mediators; methods; mice; mif; model; molecular; molecules; monocytes; mouse; mrna; neutrophils; new; novel; number; p38; pathways; patients; pcr; plasma; potential; presence; present; production; protein; rats; receptor; reduced; regulation; release; research; response; results; rheumatoid; role; selective; serum; signaling; skin; specific; stimulation; studies; study; synthesis; system; t cells; therapeutic; time; tissue; tnf; tnfa; treatment; tumor; type; university; vitro; vivo cache: cord-015147-h0o0yqv8.txt plain text: cord-015147-h0o0yqv8.txt item: #31 of 153 id: cord-015394-uj7fe5y6 author: None title: Scientific Abstracts date: 2008-12-23 words: 242809 flesch: 48 summary: The highest level of -tubulin acetylation (2.5-fold) was observed with Vinblastine at 10-fold IC 50 after 48 h. Exposure to Microtubule interacting agents and TSA resulted in increased cell surface expression of Ep-CAM in a time and dose dependent manner. Finally, we elucidated a link between the RA and TGF-pathways by assessing the impact of RA treatment of TGF-3 expression, demonstrating that TGF-3 template decreased to levels comparable to myometrial cell expression (0.84±0.12 fold). keywords: acid; activation; activity; addition; administration; adult; aea; age; aim; analysis; animals; anova; anti; antibodies; antibody; apoptosis; arteries; artery; assay; associated; association; background; baseline; binding; birth; blood; blood cells; blot; bmi; body; brain; cancer; cancer cells; cases; cells; center; cervix; cesarean; changes; clinical; collagen; concentrations; conclusions; conditions; contractions; contrast; contribute; control; control cells; control group; correlation; cortisol; crf; culture; cycle; cytokines; data; day; days; decidua; decrease; delivery; design; development; differences; differentiation; disease; dna; dose; effect; elisa; endometriosis; endometrium; endothelial; eoc cells; epithelial; estradiol; estrogen; evidence; explants; exposure; expression; expression levels; factor; fat; female; fetal; fetuses; findings; flow; fluid; fold; following; free; function; gene; gestation; glucose; gnrh; group; growth; gynecology; hcg; high; hormone; hospital; hours; human; hypertension; hypothesis; hypoxia; il-6; il-8; immune; immunohistochemistry; implantation; increase; induction; infection; inflammation; inhibitor; insulin; introduction; invasion; iugr; ivf; kinase; labor; leptin; levels; lps; male; maternal; mean; mechanisms; media; medical; medicine; medium; membranes; menstrual; methods; mice; min; model; mouse; mrna expression; mrna levels; muscle cells; myometrial; n=6; neonatal; new; non; normal; novel; nuclear; number; obesity; objective; obstetrics; offspring; onset; oocytes; outcome; ovarian; oxygen; p<0.001; p<0.05; pathway; patients; pattern; pcos; pcr; period; phase; phosphorylation; placental; placental cells; plasma; play; population; positive; post; potential; preeclampsia; pregnancies; pregnancy; pregnant; presence; present; pressure; preterm; primary; production; progesterone; proliferation; protein expression; protein levels; proteins; range; rate; rats; receptor; receptor expression; reduced; regulation; relative; release; reproductive; response; restriction; results; risk; role; samples; secretion; sections; serum; sheep; signaling; smooth; specific; staining; stress; studies; study; study group; subjects; syndrome; system; t cells; term; test; time; tissue; tnf; total; treatment; trimester; trophoblast cells; tumor; type; university; usa; uterine; uterus; vascular; vegf; vehicle; vitro; vivo; weeks; weight; western; women; years cache: cord-015394-uj7fe5y6.txt plain text: cord-015394-uj7fe5y6.txt item: #32 of 153 id: cord-015910-d9gxew91 author: Grimble, Robert F. title: The Interaction Between Nutrition and Inflammatory Stress Throughout the Life Cycle date: 2005 words: 15218 flesch: 33 summary: The effect of aging on glucocorticoid sensitivity of pro-inflammatory cytokine production was examined in elderly men, testosterone-treated elderly men, and young controls. There is now a large body of evidence suggesting that the decline in ovarian function with menopause is associated with spontaneous increases in pro-inflammatory cytokine production. keywords: body; cell; concentrations; cytokine; diabetes; disease; effect; et al; factor; gene; gsh; human; il-6; inflammation; influence; insulin; men; necrosis; patients; plasma; production; protein; response; stress; studies; study; subjects; tnf cache: cord-015910-d9gxew91.txt plain text: cord-015910-d9gxew91.txt item: #33 of 153 id: cord-016168-3hyb9stq author: None title: Pathogenesis of Fever date: 2009 words: 4069 flesch: 42 summary: key: cord-016168-3hyb9stq authors: nan title: Pathogenesis of Fever date: 2009 journal: Clinical Manual of Fever in Children DOI: 10.1007/978-3-540-78598-9_3 sha: doc_id: 16168 cord_uid: 3hyb9stq #x203A; Although infection is the most common cause of fever, fever is also a common finding in hypersensitivity reaction, autoimmune diseases, and malignancy. This steroid is thought to be responsible for fever in a few patients with adrenogenital syndrome and fevers of unknown origin. keywords: body; cells; cytokines; fever; heat; il-1; production; response; temperature cache: cord-016168-3hyb9stq.txt plain text: cord-016168-3hyb9stq.txt item: #34 of 153 id: cord-016523-pznw2ciu author: Fouqué, Amélie title: The CD95/CD95L Signaling Pathway: A Role in Carcinogenesis date: 2014-08-29 words: 8822 flesch: 26 summary: Fas cell death signaling Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling The role of receptor internalization in CD95 signaling CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) beta2, and prevents deathinducing signaling complex formation The CD95 signaling pathway: to not die and fl RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury Identifi cation of RIP1 kinase as a specifi c cellular target of necrostatins The roles of FADD in extrinsic apoptosis and necroptosis Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis Cleavage of RIP3 inactivates its caspaseindependent apoptosis pathway by removal of kinase domain Caspase 8 inhibits programmed necrosis by processing CYLD Programmed cell death: apoptosis meets necrosis Fas involvement in cytotoxicity mediated by human NK cells Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain? CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape The Fas counterattack: Fasmediated T cell killing by colon cancer cells expressing Fas ligand Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infi ltration but does not confer immune privilege upon islet allografts Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction Regulation of the proinfl ammatory effects of Fas ligand (CD95L) Cancer immunosurveillance, immunoediting and infl ammation: independent or interdependent processes? Dominant-negative Fas mutation is reversed by down-expression of c-FLIP CD95 promotes tumour growth With respect to CD95 signal, Tschopp et al. showed that FADD and RIP1 participate in the implementation of a non-apoptotic signaling pathway, which leads to a necrotic morphology without chromatin condensation and with loss of plasma membrane integrity [ 41 ] . keywords: apoptosis; caspase-8; cd95; cells; complex; death; disc; fadd; fas; formation; ligand; pathway; protein; receptor; signaling; signals; tnf; tumor; type cache: cord-016523-pznw2ciu.txt plain text: cord-016523-pznw2ciu.txt item: #35 of 153 id: cord-016960-xhzvp35g author: Berencsi, György title: Fetal and Neonatal Illnesses Caused or Influenced by Maternal Transplacental IgG and/or Therapeutic Antibodies Applied During Pregnancy date: 2012-03-08 words: 17740 flesch: 31 summary: Experimental systemic lupus erythemetosus could be induced in mice using immunisation with anti-idiotype antibodies (Ab2) specific to the anti-DNA-specific monoclonal antibodies (Mendlovic et al. 1989) . MELIMMUNE: anti-idiotype antibody that mimic the high molecular weight chondroitin sulfate proteoglycan antigen of melanoma cells (Pride et al. 1998; Murray et al. 2004; keywords: activity; anti; antibodies; antibody; antigen; arthritis; associated; blood; cancer; cells; development; disease; et al; factor; growth; human; idiotype; igg; immune; infection; inflammatory; infliximab; lupus; monoclonal; mothers; necrosis; neonatal; nieri; nieri et; patients; pregnancy; receptor; rheumatoid; risk; sle; specific; study; syndrome; therapy; tnf; treatment; tumor; virus; women cache: cord-016960-xhzvp35g.txt plain text: cord-016960-xhzvp35g.txt item: #36 of 153 id: cord-017309-pt27efu1 author: Gupta, G. S. title: Selectins and Associated Adhesion Proteins in Inflammatory disorders date: 2012-03-20 words: 25465 flesch: 31 summary: Effect of extracellular pH Genomic rearrangements on VCAM1, SELE, APEG1and AIF1 loci in atherosclerosis Lp95, a novel leptospiral protein that binds extracellular matrix components and activates E-selectin on endothelial cells Genetic polymorphisms in cytokine and adhesion molecule genes in coronary artery disease E-selectin regulates gene expression in metastatic colorectal carcinoma cells and enhances HMGB1 release Regulation of gene expression by a-tocopherol E-selectin, and P-selectin expressions in papillary thyroid carcinomas and their correlation with prognostic parameters A novel antiinflammatory role for andrographolide in asthma via inhibition of the nuclear factor-kB pathway Platelet P-selectin and GPIIb/IIIa expression after liver transplantation and resection Selectin inhibitors: a patent review The involvement of the sLe-a selectin ligand in the extravasation of human colorectal carcinoma cells Quantitative real-time RT-PCR analysis of inflammatory gene expression associated with ischemia-reperfusion brain injury Plasma indices of endothelial and platelet activation in Rheumatoid Disease: relationship to cardiovascular co-morbidity Soluble intercellular adhesion molecule-1 and E-selectin in patients with asthma exacerbation Selectins and monocyte chemotactic peptide as the markers of atherosclerosis activity Soluble adhesion molecules in pediatric rheumatic diseases Impact of prolonged cyclooxygenase-2 inhibition on inflammatory markers and endothelial function in patients with ischemic heart disease and raised Creactive protein: a randomized placebo-controlled study Antimetastatic activities of modified heparins: selectin inhibition by heparin attenuates metastasis Sulfated hexasaccharides attenuate metastasis by inhibition of P-selectin and heparanase TNF-a blockade induces a reversible but transient effect on endothelial dysfunction in patients with long-standing severe rheumatoid arthritis Transcriptional arrest of the human E-selectin gene Expression of E-selectin and its transcripts during intestinal ischemia-reperfusion injury in pigs The antitumor activity of an anti-CD54 antibody in SCID mice xenografted with human breast, prostate, non-small cell lung, and pancreatic tumor cell lines Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress Invasive amebiasis: A microcirculatory disorder? P-selectin knockout mice have improved outcomes with both warm ischemia and small bowel transplantation Soluble E-selectin in children and adolescents with type 1 diabetes Blocking E-selectin inhibits ischaemiareperfusion-induced neutrophil recruitment to the murine testis Increased platelet CD63 and Pselectin expression persist in atherosclerotic ischemic stroke Receptor tyrosine kinase EphA2 mediates thrombin-induced upregulation of ICAM-1 in endothelial cells in vitro Increased plasma levels of soluble P-selectin in rheumatic mitral stenosis The common variants of E-selectin gene in Graves' disease Aspergillus fumigatus stimulates leukocyte adhesion molecules and cytokine production by endothelial cells in vitro and during invasive pulmonary disease Pathogenic aspects of pulmonary complications in acute pancreatitis patients Effect of rosiglitazone treatment on circulating vascular and inflammatory markers in insulin-resistant subjects Changes in Pselectin expression on cardiac microvessels in blood-perfused rat hearts subjected to ischemia-reperfusion Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells Successful treatment of rheumatoid arthritis is associated with a reduction in serum sEselectin and thrombomodulin level Cytoadherence characteristics to endothelial receptors ICAM-1 and CD36 of Plasmodium falciparum populations from severe and uncomplicated malaria cases P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice Circulating E-selectin and tumor necrosis factor-alpha in extraarticular involvement and joint disease activity in rheumatoid arthritis Protein biochip array of adhesion molecule expression in peripheral blood of patients with nasal polyposis Serum P-selectin, soluble vascular cell adhesion molecule-I (s-VCAM-I) and soluble intercellular adhesion molecule-I (s-ICAM-I) levels in bladder carcinoma patients with different stages Autoantibodies and other serological markers in rheumatoid arthritis: predictors of disease activity? Phenyl methimazole inhibits TNF-a-induced VCAM-1 expression in an IFN regulatory factor-1-dependent manner and reduces monocytic cell adhesion to endothelial cells Changes in endogenous cytokines, adhesion molecules and platelets during cytokine-induced tumor necrosis Evaluation of sE-Selectin and sICAM-1 as parameters for renal function ICAM1 R241 is not associated with celiac disease in the Spanish population Comparative study of adhesion molecule expression in nodular lesions of Behçet syndrome and other forms of panniculitis Evidence of increased inflammation and microcirculatory abnormalities in patients with type 1 diabetes and their role in microvascular complications Circulating levels of soluble adhesion molecules in patients with ANCA-associated vasculitis Plasma cytokine and P-selectin levels in advanced malignancy: prognostic value and impact of low-molecular weight heparin administration Circulating adhesion molecules and purine nucleotides during kidney allograft reperfusion P-selectin-targeting of the fibrin selective thrombolytic Desmodus rotundus salivary plasminogen activator alpha1 E-and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab-an Eastern Cooperative Oncology Group Study Does colorectal cancer clinical advancement affect adhesion molecules (sP-selectin, sE-selectin and ICAM-1) concentration? Soluble P-selectin concentration in patients with colorectal cancer Serum levels of soluble E-selectin are associated with the clinical course of metastatic disease in patients with liver metastases from breast cancer Markers for endothelial activation during open heart surgery Cell adhesion molecules-update Expression of selected adhesion molecules in dermatitis herpetiformis and bullous pemphigoid Differential induction of mRNA for ICAM-1 and selectins in hepatocytes, Kupffer cells and endothelial cells during endotoxemia Serum concentrations of sICAM-1, sE-, sP-and sL-selectins in patients with Schistosoma mansoni infection and association with disease severity Biochemical markers of endothelial activation in primary hyperparathyroidism Markers of low-grade inflammation and soluble cell adhesion molecules in Chinese patients with coronary artery disease Association of Leu125Val polymorphism of platelet endothelial cell adhesion molecule-1 (PECAM-1) gene & soluble level of PECAM-1 with coronary artery disease in Asian Indians Selectins in the HIT syndrome: pathophysiologic role and therapeutic modulation Disruption of Pselectin signaling modulates cell trafficking and results in improved outcomes after mouse warm intestinal ischemia and reperfusion injury CD62 blockade with P-Selectin glycoprotein ligand-immunoglobulin fusion protein reduces ischemia-reperfusion injury after rat intestinal transplantation Independent pathways of P-selectin and complement-mediated renal ischemia/reperfusion injury IFN-g inhibits double-stranded RNAinduced E-selectin expression in human endothelial cells Candidate gene analysis of selectin cluster in patients with multiple sclerosis Enhanced expression of E-selectin on the vascular endothelium of peripheral nerve in critically ill patients with neuromuscular disorders A high frequency African coding polymorphism in the N-terminal domain of ICAM-1 predisposing to cerebral malaria in Kenya ICAM-1-dependent pathways regulate colonic eosinophilic inflammation Role of inflammation in diabetic nephropathy Circulating endothelial cells and rheumatoid arthritis: relationship with plasma markers of endothelial damage/dysfunction Variation in the ICAM1 gene is not associated with severe malaria phenotypes Interactions of the gastrotropic bacterium Helicobacter pylori with the leukocyteendothelium adhesion molecules, the selectins-A preliminary report Transforming growth factor-beta inhibits E-selectin expression on human endothelial cells P-Selectin-mediated acute inflammation can be blocked by chemically modified heparin, RO-heparin Selectin blockade plus therapy with low-dose sirolimus and cyclosporin A prevent brain death-induced renal allograft dysfunction Microvascular endothelial cells from E-selectin-deficient mice form tubes in vitro Ser128Arg gene polymorphism for E-selectin and severity of atherosclerotic arterial disease Retinoic acid inhibits the regulated expression of vascular cell adhesion molecule-1 by cultured dermal microvascular endothelial cells Leukocyte and endothelial cell adhesion molecules in inflammation focusing on inflammatory heart disease Putative outer membrane proteins of Leptospira interrogans stimulate human umbilical vein endothelial cells (HUVECS) and express during infection Expression of adhesion molecules in lungs of mice infected with Paracoccidioides brasiliensis conidia Circulating P-,L-and E-selectins in pseudoxanthoma elasticum patients Selectins and selectin ligands in extravasation of cancer cells and organ selectivity of metastasis Angiotensin receptor blockade decreases markers of vascular inflammation Implication of adhesion molecules in inflammation of the common bile duct in patients with secondary cholangitis due to biliary obstruction Serum levels of intercellular adhesion molecule ICAM-1 and E-selectin in advanced stage non-small cell lung cancer E-selectin genetic variation as a susceptibility factor for ischemic stroke E-selectin gene induction by ionizing radiation is independent of cytokine induction Nuclear factor kappaB dominant negative genetic constructs inhibit X-ray induction of cell adhesion molecules in the vascular endothelium Strategies to reduce oxidative stress in cardiovascular disease Variant isoforms of CD44 are P-and L-selectin ligands on colon carcinoma cells Soluble cell adhesion molecules in gingival crevicular fluid in periodontal health and disease E-selectin gene S128R polymorphism is associated with poor prognosis in patients with stage II or III colorectal cancer Role of adhesion molecules in the induction of restenosis after angioplasty in the lower limb The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction Tumor necrosis factor-alpha upregulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways In vivo imaging of cutaneous T-cell lymphoma migration to the skin Injury of the blood brain barrier and up-regulation of ICAM-1 in polymicrobial sepsis Expression of chemokines and adhesion molecules in human coronary artery endothelial cells infected with Chlamydia (Chlamydophila) pneumoniae Pravastatin limits radiation-induced vascular dysfunction in the skin Thrombosis and atherosclerosis Endothelial microparticles as markers of endothelial dysfunction E-selectin and Lselectin polymorphisms in patients with periodontitis Endothelial activation and systemic inflammation in obese asthmatic children Bosentan regulates the expression of adhesion molecules on circulating T cells and serum soluble adhesion molecules in systemic sclerosisassociated pulmonary arterial hypertension Significance of endothelial molecular markers in the evaluation of the severity of acute pancreatitis Serum levels of P-selectin in men with high-functioning autism The various effects of four H1-antagonists on serum substance P levels in patients with atopic dermatitis Immunohistochemistry, glycosylation and immunosuppression of glycodelin in human ovarian cancer The role of the platelet in the pathogenesis of atherothrombosis Differential metastasis inhibition by clinically relevant levels of heparins-correlation with selectin inhibition, not antithrombotic activity Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. keywords: acid; activation; activity; adhesion; adhesion molecules; atherosclerosis; blood; cancer; cell adhesion; cells; chronic; disease; effect; endothelial; et al; expression; factor; gene; heparin; icam-1; increase; inflammation; inhibition; injury; interactions; leukocyte; levels; ligand; liver; markers; metastasis; mice; molecules; patients; plasma; platelet; polymorphism; protein; risk; role; selectin; serum; sle; surface; tnf; tumor; type; vascular cache: cord-017309-pt27efu1.txt plain text: cord-017309-pt27efu1.txt item: #37 of 153 id: cord-017470-sjk7a34u author: Arlati, Sergio title: Pathophysiology of Acute Illness and Injury date: 2018-06-14 words: 16318 flesch: 30 summary: The endothelium is a key factor for production of remote organ damage as it exerts potent chemo-attracting effects on inflammatory cells, allows for leukocyte trafficking into tissues and organs, and promotes further inflammation by cytokines release. Induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55 Inflammatory cytokines and cell response in surgery Cox G IL6 is an anti-inflammatory cytokine required for controlling local or systemic acute inflammatory responses Procalcitonin as a diagnostic marker and IL-6 as a prognostic marker for sepsis Interleukin-6 levels act as a diagnostic marker for infection and a prognostic marker in patients with organ dysfunction in the intensive care unit Interleukin 6 is a useful marker for early prediction of the severity of acute pancreatitis Chemokine signaling in inflammation Complement activation in injured patients occurs immediately and is dependent on the severity of the trauma The role of the complement system in traumatic brain injury Femur fracture induces site-specific changes in T-cells immunity Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement Innate autoimmunity Natural antibodies, autoantibodies and complement activation in tissue injury Role of biological modifiers regulating the immune response after trauma The role of neuroinflammation in traumatic brain injury Evidence for a role of kallikrein-kinin system in patients with shock after blunt trauma Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases Platelets: bridging hemostasis, inflammation and immunity Coagulation abnormalities in acute lung injury and sepsis Priming for enhanced alveolar fibrin deposition after hemorrhagic shock: role for tumor necrosis factor New treatment strategies for disseminated intravascular coagulation based on current understanding of the pathophysiology Systemic inflammation and disseminated intravascular coagulation in early stage of ALI and ARDS: role of neutrophil and endothelial activation Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinases keywords: activation; acute; apoptosis; blood; cells; coagulation; cytokines; damage; dysfunction; endothelial; factor; immune; inflammation; inflammatory; injury; macrophages; monocytes; organ; patients; production; response; role; sepsis; shock; sirs; system; tissue; trauma; type cache: cord-017470-sjk7a34u.txt plain text: cord-017470-sjk7a34u.txt item: #38 of 153 id: cord-017520-r786yd6i author: Huber-Lang, Markus title: Inflammatory Changes and Coagulopathy in Multiply Injured Patients date: 2015-05-14 words: 7048 flesch: 31 summary: The STOP the bleeding campaign Blood coagulation as an intrinsic pathway for proinflammation: a mini review A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways Coagulation abnormalities in acute lung injury and sepsis Tissue factor mediates inflammation Factor VII-activating protease is activated in multiple trauma patients and generates anaphylatoxin C5a Theories of blood coagulation Protein S: a conduit between anticoagulation and inflammation Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial Early complementopathy after multiple injuries in humans Circulating complement proteins in multiple trauma patients-correlation with injury severity, development of sepsis, and outcome Complement activation in injured patients occurs immediately and is dependent on the severity of the trauma The complement system in trauma-related and ischemic tissue damage: a brief review Early expression changes of complement regulatory proteins and C5A receptor (CD88) on leukocytes after multiple injury in humans Complement: more than a 'guard' against invading pathogens? Evidence for a role of kallikrein-P6nin system in patients with shock after blunt trauma Formation of bradykinin: a major contributor to the innate inflammatory response Molecular intercommunication between the complement and coagulation systems Is interleukin 6 an early marker of injury severity following major trauma in humans? In trauma patients, PCT has been proposed as a practical biomarker for predicting posttraumatic complications such as severe SIRS, sepsis, and MODS keywords: activation; blood; cells; complement; cytokines; factor; immune; inflammatory; injury; neutrophils; organ; patients; response; system; tissue; trauma cache: cord-017520-r786yd6i.txt plain text: cord-017520-r786yd6i.txt item: #39 of 153 id: cord-017639-wtc8bml5 author: El-Radhi, A. Sahib title: Pathogenesis of Fever date: 2019-01-02 words: 5145 flesch: 43 summary: key: cord-017639-wtc8bml5 authors: El-Radhi, A. Sahib title: Pathogenesis of Fever date: 2019-01-02 journal: Clinical Manual of Fever in Children DOI: 10.1007/978-3-319-92336-9_3 sha: doc_id: 17639 cord_uid: wtc8bml5 The generation of fever involves the following steps: numerous substances from outside the body, exogenous pyrogens, initiate the fever cycle. The induction of fever results in inhibition of bacterial growth, increased bactericidal effects of neutrophils, production of acute-phase protein synthesis and other physiological changes such as anorexia and somnolence. keywords: body; cells; cytokines; fever; heat; il-1; macrophages; production; pyrogens; response; temperature cache: cord-017639-wtc8bml5.txt plain text: cord-017639-wtc8bml5.txt item: #40 of 153 id: cord-017640-i8h48ny6 author: Fouqué, Amélie title: The CD95/CD95L Signaling Pathway: A Role in Carcinogenesis date: 2020-01-03 words: 8860 flesch: 32 summary: Sequence identity with the Fas antigen Ceramide-mediated clustering is required for CD95-DISC formation S-glutathionylation uncouples eNOS and regulates its cellular and vascular function S-nitrosylation of the death receptor fas promotes fas ligand-mediated apoptosis in cancer cells Palmitoylation is required for efficient Fas cell death signaling Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling The role of receptor internalization in CD95 signaling CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) beta2, and prevents death-inducing signaling complex formation The CD95 signaling pathway: to not die and fly RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury Identification of RIP1 kinase as a specific cellular target of necrostatins The roles of FADD in extrinsic apoptosis and necroptosis Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain Caspase 8 inhibits programmed necrosis by processing CYLD Programmed cell death: apoptosis meets necrosis Fas involvement in cytotoxicity mediated by human NK cells Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain? CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape The Fas counterattack: Fasmediated T cell killing by colon cancer cells expressing Fas ligand Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction Regulation of the proinflammatory effects of Fas ligand (CD95L) Cancer immunosurveillance, immunoediting and inflammation: independent or interdependent processes? Dominant-negative Fas mutation is reversed by down-expression of c-FLIP CD95 promotes tumour growth The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway CD95-mediated cell signaling in cancer: mutations and post-translational modulations Monoclonal antibody-mediated tumor regression by induction of apoptosis Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family Involvement of Fas ligand and Fasmediated pathway in the cytotoxicity of human natural killer cells Fas ligand-induced apoptosis as a mechanism of immune privilege A role for CD95 ligand in preventing graft rejection Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn Autoimmunity in mice bearing lprcg: a novel mutant gene Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand The many roles of FAS receptor signaling in the immune system Structure of the human APO-1 gene NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain The Fas-FADD death domain complex structure unravels signalling by receptor clustering Solution NMR investigation of the CD95/FADD homotypic death domain complex suggests lack of engagement of the CD95 C terminus The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations Homotypic FADD interactions through a conserved RXDLL motif are required for death receptor-induced apoptosis Inhibition of death receptor signals by cellular FLIP Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis Two CD95 (APO-1/Fas) signaling pathways Two CD95 tumor classes with different sensitivities to antitumor drugs CD95 engagement mediates actin-independent and -dependent apoptotic signals Signal transduction mediated by bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis XIAP discriminates between type I and type II FAS-induced apoptosis The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases X-linked IAP is a direct inhibitor of cell-death proteases IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases keywords: apoptosis; caspase-8; cd95; cells; complex; death; fadd; fas; formation; ligand; pathway; protein; receptor; signaling; signals; tnf; tumor; type cache: cord-017640-i8h48ny6.txt plain text: cord-017640-i8h48ny6.txt item: #41 of 153 id: cord-018764-02l423mk author: Clark, Ian A. title: The molecular basis of paediatric malarial disease date: 2007 words: 10015 flesch: 31 summary: Severe falciparum malaria is an acute systemic disease that can affect multiple organs, including those in which few parasites are found. Metabolic acidosis, often associated with hyperlactataemia, has been described in African children with severe falciparum malaria [111, 112] . keywords: acidosis; blood; cell; cerebral; children; cytokines; disease; factor; falciparum; human; infection; lactate; malaria; patients; plasmodium; sepsis; tnf cache: cord-018764-02l423mk.txt plain text: cord-018764-02l423mk.txt item: #42 of 153 id: cord-020643-0yzkqykg author: Müller-Werdan, U. title: Schock date: 2006 words: 30700 flesch: 35 summary: 6.6.4 Traumatischer Schock -419 6.6.5 Anaphylaktischer Schock -419 Die Reduktion der effektiven Gewebeperfusion kann dabei hervorgerufen werden durch eine Abnahme der Herzleistung, durch Störungen der Makro-und Mikrozirkulation mit verminderter Perfusion, durch eine kritische Abnahme des Blutvolumens, eine Beeinträchtigung der O 2 -Aufnahme in der Lunge und der O 2 -Abgabe Noch ausstehend ist der Nachweis der klinischen Wirksamkeit einer Antioxidanzientherapie (Mullan u. McCloskey 2002) , der in zahlreichen Studien für folgende Substanzen nicht erbracht werden konnte: Superoxiddismutase, Katalase, Glutathionperoxidase, Ascorbinsäure, Glutathion, Harnsäure, α-Tocopherol, Karotinoide, der Xanthinoxidasehemmer Allopurinol, Lazaroide, Pyruvat (Fink 2003) , der Hemmung der Komplementaktivierung (Ciurana u. Hack 2002) , von PARP-Inhibitoren (Szabó u. Liaudet 2002; Liaudet et al. 2001 ) oder der Inhibition der MAP-Kinasen (Tulleken et al. 2001 ). keywords: abb; aber; abnahme; abschn; acute; adrenalin; aktivierung; akuten; allerdings; als; anaphylaxie; anstieg; apache; auch; auf; auf der; auf eine; aufgrund; auftreten; aus; bedeutung; behandlung; bei; bei der; bei einem; bei patienten; bei sepsis; beim; bereits; bis; bisher; blutdruck; blutung; bzw; cardiac; care; coronary; dabei; dafür; damit; dann; das; dass; defi; dem; der; des; die; diese; dobutamin; durch; durch die; durch eine; dysfunktion; eine; einsatz; einsatz von; endotoxin; erforderlich; erhöht; ersten; et al; etwa; failure; falle; führen; führt; für; für den; gabe; gabe von; haben; herz; herzindex; herzinfarkt; herzinsuffi; häufi; iabp; infarction; infl; infolge; innerhalb; inotrope; insbesondere; intensivpatienten; ist; ist bei; ist der; ist die; ist eine; jedoch; kann; kann die; kardiogenen; katecholamine; kgkg; klinische; kommen; kommt; konnte; kranken; kreislauf; kritisch; können; letalität; lässt; lösungen; mediatoren; medicine; mehr; min; mit; mit der; mit einer; mittels; mods; muss; myokarddepression; müller; nach; ndet; neben; nicht; noch; nur; oder; ohne; outcome; patienten; patienten mit; patients; pci; positiv; prognose; protein; reaktionen; reanimation; regel; registry; resuscitation; scheint; schock; schock ist; schockformen; schwerer; score; sehr; sein; selten; sepsis; sepsispatienten; septic; septischen; sich; sie; sind; sogar; sollte; sondern; sowie; sowohl; spezifi; stadium; stickoxid; studie; störungen; substanzen; systemischen; tabelle; tage; therapie; tnf; trauma; treatment; trial; trotz; und; und bei; und der; und eine; unter; ursache; vasopressin; ventricular; vergleich; volumensubstitution; von; von der; vor; weitere; weniger; werden; werden kann; wie; wird; wirkung; während; zienz; zu einer; zum; zur; zytokine; über cache: cord-020643-0yzkqykg.txt plain text: cord-020643-0yzkqykg.txt item: #43 of 153 id: cord-020757-q4ivezyq author: Saikumar, Pothana title: Apoptosis and Cell Death: Relevance to Lung date: 2010-05-21 words: 7428 flesch: 33 summary: Cell death has become an area of intense interest and investigation in science and medicine because of the recognition that cell death, in general, and apoptosis, in par-ticular, are important features of many biologic processes. As time has progressed, however, apoptotic cell death has been shown to occur in many cell types under a variety of physiologic and pathologic conditions. keywords: activation; apoptosis; caspase-8; caspases; cell; cell death; death; factor; fas; infl; lung; membrane; protein; receptor; role; tnf cache: cord-020757-q4ivezyq.txt plain text: cord-020757-q4ivezyq.txt item: #44 of 153 id: cord-021266-afs9eb40 author: El Gendy, Fady M. title: The role of Tumor necrosis factor alpha −308 G>A promoter polymorphism in pediatric community acquired pneumonia date: 2020-02-10 words: 3760 flesch: 44 summary: Our main finding was that the frequency of AG genotype and that of the AA+AG genotypes were significantly lower among CAP patients compared with controls and logistic regression analysis indicated a significant negative association of genotypes with CAP. It should be pointed out that, to the best of our knowledge, our current study is the first to evaluate the role of −308 G>A polymorphism in pediatric CAP patients, but a relevant study of 120 very low birth weight mechanically ventilated infants found that the incidence of nosocomial pneumonia was not significantly different between infants with GG genotype and those having AA/AG keywords: association; cap; patients; pneumonia; polymorphism; severity; study; tnf cache: cord-021266-afs9eb40.txt plain text: cord-021266-afs9eb40.txt item: #45 of 153 id: cord-022353-q2k2krnm author: W. Quimby, Fred title: Clinical Chemistry of the Laboratory Mouse date: 2007-09-02 words: 30268 flesch: 42 summary: Although we hope all readers of this chapter will benefit from this section on assays and instruments, the primary purpose of this chapter is to briefly introduce the reader to areas where methods in clinical chemistry are changing and provide sources of information for services, reagents (including test kits), and instrumentation, specifically for testing biomarkers (including traditional analytes) in mouse serum, plasma, or urine. Growth in the number of reagents capable of quantitating analytes in mouse serum is illustrated in Table 6 -2. keywords: acid; activity; addition; age; analytes; assays; atherosclerosis; binding; biomarkers; blood; cells; chemistry; chemokines; cholesterol; complement; corticosterone; development; disease; effects; elisa; enzyme; et al; expression; factor; function; gene; glucose; growth; hdl; hepatic; hormone; human; insulin; kits; ldl; levels; liver; metabolism; mice; mouse; murine; muscle; new; plasma; production; protein; quimby; receptor; response; role; secretion; serum; strains; surface; tissue; total; transgenic; type cache: cord-022353-q2k2krnm.txt plain text: cord-022353-q2k2krnm.txt item: #46 of 153 id: cord-022526-j9kg00qf author: Jones, Samuel L. title: Disorders of the Gastrointestinal System date: 2009-05-18 words: 108877 flesch: 36 summary: Abdominal radiographs are reserved for smaller horses and ponies. In addition, one may detect mineral opacity within the colon on abdominal radiographs, particularly in foals, ponies, and small horses. keywords: absorption; acid; activity; acute; addition; administration; adult horses; bacteria; blood; body; bowel; cases; cause; cells; chronic; colic; colitis; colon; colonic; concentration; damage; diagnosis; diarrhea; disease; distention; effects; endothelial; endotoxemia; endotoxin; epithelium; equine; esophageal; esophagus; examination; factors; flow; fluid; foals; gastric; gastrointestinal; horses; hours; human; ileus; impaction; increase; infection; inflammation; inflammatory; injury; intestine; ischemia; lesions; lipopolysaccharide; loss; mediators; motility; mucosal; neutrophils; normal; obstruction; pain; patients; peritoneal; peritonitis; plasma; production; products; protein; proximal; rectal; release; response; result; role; salmonella; secretion; serum; signs; specific; squamous; study; surgery; therapy; tissue; tract; treatment; ulceration; vascular; wall cache: cord-022526-j9kg00qf.txt plain text: cord-022526-j9kg00qf.txt item: #47 of 153 id: cord-022631-s4n24xij author: Jonsson, M. V. title: Germinal Centres in Primary Sjögren's Syndrome Indicate a Certain Clinical Immunological Phenotype date: 2008-06-28 words: 16926 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-022631-s4n24xij.txt plain text: cord-022631-s4n24xij.txt item: #48 of 153 id: cord-022888-dnsdg04n author: None title: Poster Sessions date: 2009-08-19 words: 189173 flesch: 41 summary: Our aim is to describe how B cell lymphoma cells respond to TGF-b compared to normal peripheral B cells, to create an overview of the different signaling pathways involved, and to characterize the mechanisms behind the loss of sensitivity to TGF-b. Methods: Proliferation assays were performed on 11 different B-cell lymphoma cell lines and normal peripheral B cells to screen for TGF-b-induced effects. Using a CD3 and CD28 activation model system -TLR4 presence on CD4+ cells is found in mouse T cells, human T cells and Jurkat cell lines. keywords: + cells; ability; absence; activity; addition; analysis; antibodies; antibody; antigen; apoptosis; apoptotic; assay; associated; autoimmune; b cells; b t; binding; blood; bone; c mice; cancer cells; capacity; cd4; cd8 +; cd8 cells; cd8 t; cell activation; cell activity; cell culture; cell cycle; cell death; cell development; cell differentiation; cell epitopes; cell function; cell level; cell lines; cell membrane; cell population; cell proliferation; cell receptor; cell responses; cell subsets; cell surface; cell tolerance; cell types; cells cells; changes; chronic; class; clinical; colitis; complex; conclusion; contrast; control; control cells; cross; ctl; cytokine; cytokine production; cytometry; cytotoxic t; data; day; days; dcs; deficient; delta t; dendritic; disease; dna; early; effector cells; effector t; effects; elisa; expansion; experiments; expression; expression levels; factor; family; findings; flow; following; formation; function; gamma; gd cells; gd t; gene; gene expression; group; high; hiv; hla; host; human; ifn; ifng; igg; il-10; il-2; il-4; il-6; immune; immunity; increase; independent; induction; infected; infection; inflammation; inflammatory; inhibition; inkt; interaction; intracellular; levels; lps; macrophages; major; marrow cells; mast cells; mechanisms; membrane; memory t; methods; mhc; mice; model; molecules; monocytes; mouse; mouse t; mrna; murine; negative; neutrophils; new; nkt cells; non; normal; novel; number; objectives; pathway; patients; pcr; peptide; peripheral; plasma cells; play; positive; potential; presence; presentation; primary; production; promoter; protein; protein expression; receptors; regulation; regulatory; release; results; role; secretion; serum; signaling; skin; sle; specific; spleen; stem cells; stimulation; studies; study; surface expression; system; t cells; t em; t h; t helper; t lymphocytes; target cells; tcr; test; th1 cells; time; tissue; tlr; tnf; tolerance; transcription; treatment; tumor cells; type; university; vaccination; vaccine; vg9vd2 t; virus; vitro; vivo; work cache: cord-022888-dnsdg04n.txt plain text: cord-022888-dnsdg04n.txt item: #49 of 153 id: cord-022940-atbjwpo5 author: None title: Poster Sessions date: 2016-09-07 words: 241687 flesch: 44 summary: Among used cancer cell lines, ERICD was highly expressed and ARID3A had lower expression in U-2OS (osteosarcoma), A-172 (glioblastoma) and A549 (lung cancer). Clear cell renal cell cancer (ccRCC) with metastases has pour prognosis: 5-year survival is about 9%. keywords: a549 cells; acid; activation; activities; activity; activity levels; acute; addition; administration; affinity; agents; aim; albumin; allele; alterations; alternative; amino; analysis; analysis results; animals; ankara; anti; antibodies; antibody; anticancer; antioxidant; apoptosis; applications; approach; assay; association; bacteria; beta; binding; biology; blood; body; bone; brain; breast cancer; cancer cells; cancer group; cancer patients; cancer stem; cancer treatment; cancers; cause; cell cycle; cell death; cell growth; cell lines; cell proliferation; cell survival; cell viability; changes; characterization; chemical; cholesterol; chronic; clinical; coli; colorectal; combination; comparison; complex; complexes; compounds; concentrations; conclusion; conditions; content; control cells; control group; control study; controls; correlation; culture; curcumin; current; cytotoxic; damage; data; day; days; decrease; department; detection; determination; development; diabetes; differences; differentiation; discussion; disease; dna; domain; dose; drug; effects; elevated; elisa; energy; enzyme; enzyme activity; ethanol; experimental; expression analysis; expression levels; expressions; extract; factor; faculty; family; fat; findings; flow; fluorescence; fold; food; formation; free; function; gene expression; genes; genetic; genome; genotype; glucose; glutathione; group; growth; gsh; health; hours; human; immune; increase; inflammation; inflammatory; inhibition; inhibitors; injury; institute; insulin; interaction; intracellular; introduction; invasion; investigation; ischemia; kinase; laboratory; lead; levels; light; like; lipid; liver; low; lung; male; manner; markers; mass; materials; matrix; mcf-7; mda; mda levels; mean; mechanisms; medical; medicine; medium; membrane; metabolism; methods; methylation; mice; microscopy; migration; mirnas; mitochondrial; model; modified; molecular; molecules; mrna; muscle; mutant; mutations; n =; nanoparticles; negative; non; normal; novel; number; obese; obesity; oil; order; oxidative; oxygen; p =; p-02.08.5; parameters; pathway; patients; pcr; peptide; phase; plant; plasma; play; point; polymorphisms; population; potential; presence; present; process; processes; production; products; profile; progression; promoter; properties; prostate; prostate cancer; protective; protein; protein expression; protein levels; purpose; radical; range; rate; rats; reaction; receptor; recombinant; region; regulation; related; relationship; research; resistance; response; results; risk; role; samples; science; scientific; screening; sequence; serum; serum levels; signaling; site; size; sod; species; specific; stability; stage; status; stem cells; strain; stress; structure; studies; study; study group; subjects; surface; survival; synthesis; system; target; technique; temperature; test; tested; therapeutic; therapy; time; tissue; tnf; total; transcription; treatment; treatment group; tumor; tumor cells; turkey; type; university; use; values; vitamin; vitro; water; weight; western; wild; women; work; years cache: cord-022940-atbjwpo5.txt plain text: cord-022940-atbjwpo5.txt item: #50 of 153 id: cord-023372-ft8cp9op author: Rahman, Q. K. title: The Immunomodulatory Effect of Heat Shock Protein 70: Immunization with a DNA Construct Based on the Malarial Antigen Fused with a Fragment of HSP 70 Primes for a Th‐1 Type of Response date: 2008-06-28 words: 16884 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; mice; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023372-ft8cp9op.txt plain text: cord-023372-ft8cp9op.txt item: #51 of 153 id: cord-023373-6wh1kb3p author: Melchjorsen, J. title: Differential Requirements for Toll‐Like Receptor Signalling for Induction of Chemokine Expression by Herpes Simplex Virus and Sendai Virus date: 2008-06-28 words: 16861 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; molecules; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type; virus cache: cord-023373-6wh1kb3p.txt plain text: cord-023373-6wh1kb3p.txt item: #52 of 153 id: cord-023374-87ob1exq author: Sukhija, S. title: Levels, Complement Activity and Polymorphisms of Mannan‐Binding Lectin in Patients of Bronchial Asthma with Allergic Rhinitis date: 2008-06-28 words: 16911 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023374-87ob1exq.txt plain text: cord-023374-87ob1exq.txt item: #53 of 153 id: cord-023375-x4p187u7 author: Alitalo, A. title: Lysine‐Dependent Binding of OspE to the C‐terminus of Factor H Mediates Complement Resistance in Borrelia burgdorferi date: 2008-06-28 words: 17080 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; ospe; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023375-x4p187u7.txt plain text: cord-023375-x4p187u7.txt item: #54 of 153 id: cord-023387-tyeh14wz author: Hvas, C. L. title: Probiotic Bacteria Induce Regulatory Cytokine Production via Dendritic Cells date: 2008-06-28 words: 16914 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; expression; factor; human; ifn; lactobacillus; levels; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023387-tyeh14wz.txt plain text: cord-023387-tyeh14wz.txt item: #55 of 153 id: cord-023388-btbf6wkg author: Hoffmann, H. J. title: Decrease in Fine T‐cell Subset ratio MT2/MT1 During Steroid Reduction of Asthmatic Patients date: 2008-06-28 words: 16939 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023388-btbf6wkg.txt plain text: cord-023388-btbf6wkg.txt item: #56 of 153 id: cord-023389-ilrp8vb7 author: Wefer, J. title: Protective DNA Vaccination Against MOG(91‐108)‐Induced Experimental Autoimmune Encephalomyelitis Involves Induction of IFNβ date: 2008-06-28 words: 16866 flesch: 43 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; dna; expression; factor; human; ifn; levels; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023389-ilrp8vb7.txt plain text: cord-023389-ilrp8vb7.txt item: #57 of 153 id: cord-023390-5hcgdlmt author: Bhuvanath, S. title: Inflammatory Cytokine Modulation of Cancer Cell Proliferation date: 2008-06-28 words: 16839 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokines; data; expression; factor; human; ifn; levels; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023390-5hcgdlmt.txt plain text: cord-023390-5hcgdlmt.txt item: #58 of 153 id: cord-023391-bq5w3jk9 author: Utermöhlen, O. title: Delayed Elimination of the LCM Virus from Acid Sphingomyelinase‐Deficient Mice due to Reduced Expansion of Virus‐Specific CD8(+) T Lymphocytes date: 2008-06-28 words: 16877 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; expression; factor; human; ifn; levels; mbl; mice; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023391-bq5w3jk9.txt plain text: cord-023391-bq5w3jk9.txt item: #59 of 153 id: cord-023392-axd0901z author: Hansen, T. K. title: Association between Mannose‐Binding Lectin and Vascular Complications in Type 1 Diabetes date: 2008-06-28 words: 16965 flesch: 43 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023392-axd0901z.txt plain text: cord-023392-axd0901z.txt item: #60 of 153 id: cord-023393-8nye3nc8 author: Krarup, A. title: Mannan‐Binding Lectin, L‐Ficolin and H‐Ficolin Selectively Binds to Different Bacteria date: 2008-06-28 words: 16840 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023393-8nye3nc8.txt plain text: cord-023393-8nye3nc8.txt item: #61 of 153 id: cord-023394-ptfjxpo6 author: Isa, A. title: Mapping of the Ex Vivo Cellular Immune Response Against the Complete Human Parvovirus B19 Genome During Acute Infection date: 2008-06-28 words: 16925 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023394-ptfjxpo6.txt plain text: cord-023394-ptfjxpo6.txt item: #62 of 153 id: cord-023402-8qfmo6rq author: Reinholdt, J. title: Pneumococcal IgA1 Protease Activity Interferes with Opsonophagocytosis of Streptococcus Pneumoniae Mediated by Serotype‐Specific Human Monoclonal IgA1 Antibodies date: 2008-06-28 words: 17031 flesch: 43 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibodies; antibody; bacteria; binding; blood; cells; complement; cytokine; expression; factor; human; ifn; iga1; levels; mbl; patients; production; protease; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023402-8qfmo6rq.txt plain text: cord-023402-8qfmo6rq.txt item: #63 of 153 id: cord-023403-jzdrvfvr author: Ahlfors, E. title: Proliferation of Cells in the Oral Mucosa, the Ear Skin and the Regional Lymph Nodes in Mice Sensitized and Elicited with a Hapten date: 2008-06-28 words: 16946 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. Scand J Immunol DOI: 10.1111/j.0300-9475.2004.01423ac.x sha: doc_id: 23403 cord_uid: jzdrvfvr During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; mice; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023403-jzdrvfvr.txt plain text: cord-023403-jzdrvfvr.txt item: #64 of 153 id: cord-023407-s85g7g0x author: Huang, Y.‐M. title: Anti‐Inflammatory Liver X Receptors and Related Molecules in Multiple Sclerosis Patients from Sardinia and Sweden date: 2008-06-28 words: 17096 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; antibody; bacteria; binding; blood; cells; complement; cytokine; expression; factor; human; ifn; levels; mbl; molecules; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023407-s85g7g0x.txt plain text: cord-023407-s85g7g0x.txt item: #65 of 153 id: cord-023410-eblcf902 author: Kollgaard, T. M. title: Clonally Expanded CD8(+) T cells in Allogeneic Bone Marrow Transplantation date: 2008-06-28 words: 16936 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; patients; presence; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023410-eblcf902.txt plain text: cord-023410-eblcf902.txt item: #66 of 153 id: cord-023411-iszb5qlk author: Astrinidou‐Vakaloudi, A. title: Presence of Helicobacter pylori Antibodies in Haemodialysis Patients date: 2008-06-28 words: 16900 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibodies; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023411-iszb5qlk.txt plain text: cord-023411-iszb5qlk.txt item: #67 of 153 id: cord-023414-xxw5kptr author: Chistensen, H. R. title: Characterization of a Large Panel of Lactic Acid Bacteria Derived from the Human Gut for their Capacity to Polarize Dendritic Cell date: 2008-06-28 words: 16935 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; lactobacillus; levels; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023414-xxw5kptr.txt plain text: cord-023414-xxw5kptr.txt item: #68 of 153 id: cord-023415-hhvmsn5b author: Karlsson, H. title: Pattern of Cytokine Responses to Gram‐Positive and Gram‐Negative Commensal Bacteria is Profoundly Changed when Monocytes Differentiate into Dendritic Cells date: 2008-06-28 words: 16930 flesch: 43 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; dcs; expression; factor; human; ifn; levels; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023415-hhvmsn5b.txt plain text: cord-023415-hhvmsn5b.txt item: #69 of 153 id: cord-023417-by18aczt author: Vilhelmsson, M. title: The Malassezia sympodialis Allergen Mala s 11 with Sequence Similarity to Manganese Superoxide Dismutase Induces Maturation and Production of Inflammatory Cytokines in Human Dendritic Cells date: 2008-06-28 words: 16952 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokines; data; expression; factor; human; ifn; levels; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023417-by18aczt.txt plain text: cord-023417-by18aczt.txt item: #70 of 153 id: cord-023419-lnmc6vv5 author: Steinhauer, C. title: High‐Throughput Proteomics on Antibody‐based Microarrays: the Importance of Probe and Surface Design date: 2008-06-28 words: 16905 flesch: 43 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023419-lnmc6vv5.txt plain text: cord-023419-lnmc6vv5.txt item: #71 of 153 id: cord-023421-1d1gf7az author: Sønder, S. U. S. title: Monitoring Patients Treated with Type 1 Interferons: Antiviral versus MxA Induction Assays date: 2008-06-28 words: 16886 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; patients; presence; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023421-1d1gf7az.txt plain text: cord-023421-1d1gf7az.txt item: #72 of 153 id: cord-023425-3sjsogvq author: Røntved, C. M. title: Do High and Low Tumour Necrosis Factor‐α Responders Exist in Dairy Cows? date: 2008-06-28 words: 16906 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023425-3sjsogvq.txt plain text: cord-023425-3sjsogvq.txt item: #73 of 153 id: cord-023429-x52gbklw author: Ruseva, M. title: Mannan‐Binding Lectin Inhibits Humoural Responses date: 2008-06-28 words: 16901 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; mice; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023429-x52gbklw.txt plain text: cord-023429-x52gbklw.txt item: #74 of 153 id: cord-023430-5zuewjv2 author: Nilkaeo, A. title: Interleukin‐18 Inhibition of Oral Carcinoma Cell Proliferation date: 2008-06-28 words: 16928 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; mice; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023430-5zuewjv2.txt plain text: cord-023430-5zuewjv2.txt item: #75 of 153 id: cord-023431-zjyrhlxn author: Sigmundsdóttir, H. title: Differential Effects of Interleukin‐12 and Interleukin‐10 on Superantigen‐Induced Expression of Cutaneous Lymphocyte‐Associated Antigen and αEβ7 Integrin (CD103) by CD8(+) T cells date: 2008-06-28 words: 16888 flesch: 43 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023431-zjyrhlxn.txt plain text: cord-023431-zjyrhlxn.txt item: #76 of 153 id: cord-023433-d1b7qvhs author: Siassi, M. title: Expression of Human Collectins in Colorectal Carcinoma date: 2008-06-28 words: 16927 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023433-d1b7qvhs.txt plain text: cord-023433-d1b7qvhs.txt item: #77 of 153 id: cord-023438-g0k0vvdc author: Krog, J. title: The Effects of Hyperbaric Exposure on Human Peripheral Blood Mononuclear Cells, with Special Emphasis on Natural Killer Cell Cytotoxicity and Subsets date: 2008-06-28 words: 16901 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023438-g0k0vvdc.txt plain text: cord-023438-g0k0vvdc.txt item: #78 of 153 id: cord-023439-r04y1j22 author: Hedegaard, C. J. title: The Role of Immune Complexes Consisting of Myelin Basic Protein (MBP), Anti‐MBP Antibodies and Complement in Promoting CD4(+) T‐cell Responses to MBP in Health and Multiple Sclerosis date: 2008-06-28 words: 16953 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibodies; antibody; bacteria; binding; blood; cells; complement; cytokine; expression; factor; human; ifn; levels; mbl; patients; presence; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023439-r04y1j22.txt plain text: cord-023439-r04y1j22.txt item: #79 of 153 id: cord-023441-q83y12sk author: Draborg, H. title: Recominant Expression and Immunological Characterization of House Dust Mite Allergen Der P 1 date: 2008-06-28 words: 16926 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023441-q83y12sk.txt plain text: cord-023441-q83y12sk.txt item: #80 of 153 id: cord-023443-pvz7dll9 author: None title: Abstracts for the Scandinavian Society for Immunology 35th Annual Meeting and 20th Summer School date: 2004-06-02 words: 16664 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; data; expression; factor; human; ifn; levels; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type cache: cord-023443-pvz7dll9.txt plain text: cord-023443-pvz7dll9.txt item: #81 of 153 id: cord-023445-c4tqioz1 author: Lauridsen, C. title: Supplementation of Vitamin C to Weaner Diets Increases IgM Concentration and Improves the Biological Activity of Vitamin E in Alveolar Macrophages date: 2008-06-28 words: 16968 flesch: 44 summary: Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment. During contact sensitivity reaction, immune cells proliferate. keywords: activation; activity; antibody; bacteria; binding; blood; cancer; cells; complement; cytokine; expression; factor; human; ifn; levels; macrophages; mbl; patients; production; protein; response; results; role; stimulation; study; t cells; tnf; tumour; type; vitamin cache: cord-023445-c4tqioz1.txt plain text: cord-023445-c4tqioz1.txt item: #82 of 153 id: cord-023928-9a1w174h author: Thomas, Neal J. title: Genetic Predisposition to Critical Illness in the Pediatric Intensive Care Unit date: 2011-12-16 words: 12261 flesch: 40 summary: It is unlikely as there are no reports of associations between surfactant protein gene polymorphisms and outcomes from pulmonary disease. As will be discussed below, genetic variations that infl uence the activity or level of the protein in several of these candidate genes have been examined in gene association studies in patients with ALI. keywords: adults; ali; coding; disease; expression; gene; infl; levels; polymorphisms; protein; response; risk; sepsis; studies; uence; variations cache: cord-023928-9a1w174h.txt plain text: cord-023928-9a1w174h.txt item: #83 of 153 id: cord-023935-o2ffxgnn author: Lorts, Angela title: Sepsis date: 2011-12-16 words: 11116 flesch: 34 summary: More recently, a polymorphism within the CD14 promoter gene (C to T transition at base pair -159) was identifi ed with a particular genotype over-represented among septic shock patients compared to healthy controls. It is believed that genetic differences among hosts are at least in part responsible for this variability in sepsis responses. keywords: ammatory; blood; children; il-1; infl; lps; mortality; oxygen; patients; pressure; protein; receptor; response; sepsis; shock; studies; tnf; uid; volume cache: cord-023935-o2ffxgnn.txt plain text: cord-023935-o2ffxgnn.txt item: #84 of 153 id: cord-023950-nv0pbbu2 author: Schnyder, Bruno title: Dual Role of Th17 Cytokines, IL-17A,F, and IL-22 in Allergic Asthma date: 2012-07-19 words: 4459 flesch: 34 summary: IL-17RC receptor complex Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 Divergent pro-and anti inflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain Interleukin-17 is a negative regulator of established allergic asthma Role of IL-23 and Th17 cells in airway inflammation in asthma Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides Neutrophilic airway inflammation and IL-17 Activation of peripheral Th17 lymphocytes in patients with asthma Th17 immunity in patients with allergic asthma Interleukin-22 is a negative regulator of the allergic response The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A Resolution of allergic airway inflammation and airway hyperreactivity is mediated by IL-17-producing {gamma}{delta}T cells Regulation of inflammatory responses by IL-17F Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis Requirement of IL-17 receptor signaling in radiation-resistant cells in the joint for full progression of destructive synovitis Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1 IL-22 increases the innate immunity of tissues Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine IL-10-treated dendritic cells IL-10-treated dendritic cells decrease airway hyperresponsiveness and airway inflammation in mice IL-22 is produced by innate lymphoid cells and limits inflammation in allergic airway disease IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T (H)-17 cell-mediated pathology IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages Interleukin 17 modulates the immune response to vaccinia virus infection Enhancement of acute phase and inhibition of chronic phase of experimental autoimmune neuritis in Lewis rats by intranasal administration of recombinant mouse interleukin 17: potential immunoregulatory role IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts Constitutive and inflammatory mediator-regulated fractalkine expression in human ocular tissues and cultured cells IL-17 suppresses TNFalpha-induced CCL27 production through induction of COX-2 in human keratinocytes IL-17 reduces TNF-induced Rantes and VCAM-1 expression Functional assay for human CD4 + CD25+ Treg cells reveals an age-dependent loss of suppressive activity Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia Specificity of regulatory CD4 + CD25+ T cells for self-T cell receptor determinants TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3 Hydrodynamicbased delivery of an interleukin-22-Ig fusion gene ameliorates experimental autoimmune myocarditis in rats IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia Dual effects of p38 MAPK on TNF-dependent bronchoconstriction and TNF-independent neutrophil recruitment in lipopolysaccharide-induced acute respiratory distress syndrome Chemokines and their receptors as potential targets for the treatment of asthma Neutrophils and immunity: challenges and opportunities Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma Interleukin-22: a potential immunomodulatory molecule in the lung Requirement for IL-13 independently of IL-4 in experimental asthma Anti-interleukin-4 therapy Immunologic basis of antigen-induced airway hyperresponsiveness T-cell-derived interleukin-17 regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of the p38 mitogen-activated protein kinase cascade: role of distal sequences in the 3 0 -untranslated region of COX-2 mRNA Stimulus-specific induction of a novel nuclear factor-kappaB regulator, IkappaB-zeta, via Toll/Interleukin-1 receptor is mediated by mRNA stabilization Eosinophil recruitment to the lung in a murine model of allergic inflammation. The role of T cells, chemokines and adhesion receptors Inhibition of airway inflammation by aminoterminally modified RANTES/CC chemokine ligand 5 analogues is not mediated through CCR3 Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice Endogenous and exogenous IL-6 inhibit aeroallergen-induced Th2 inflammation Enhanced airway inflammation and decreased subepithelial fibrosis in interleukin 6-deficient mice following chronic exposure to aerosolized antigen Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3 Anti-IgE efficacy in murine asthma models is dependent on the method of allergen sensitization I kappaB-beta regulates the persistent response in a biphasic activation of NF-kappa B IkappaBbeta, but not IkappaBalpha, functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cells STAT3 links IL-22signaling in intestinal epithelial cells to mucosal wound healing Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells The aryl hydrocarbon receptor links T(H)17-cell-mediated autoimmunity to environmental toxins Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9 IL-17 and IL-22: siblings, not twins Interleukin-17 regulation: an attractive therapeutic approach for asthma Update in the mechanisms of allergen-specific immunotherapy IL-22 and TNF-a represent a key cytokine combination for epidermal integrity during infection with Candida albicans The role of interleukin-17 in the Helicobacter pylori induced infection and immunity Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3 IL-22 mediates mucosal host defense against gram-negative bacterial pneumonia ) keywords: cells; il-17a; il-22; inflammation; lung; production; response; role; th2; tnf cache: cord-023950-nv0pbbu2.txt plain text: cord-023950-nv0pbbu2.txt item: #85 of 153 id: cord-034340-3ksfpaf7 author: None title: Proceedings of the 26th European Paediatric Rheumatology Congress: part 2: Virtual. 23 - 26 September 2020 date: 2020-10-28 words: 35133 flesch: 46 summary: Results: Of the 35 metabolites measured, 23 were significantly lower in JIA patients before the Etanercept treatment compared to the healthy control group. Urine metabolite ratios reflecting CYP21 and 11β-HSD2 enzymatic activity indicate that these two enzyme activities were lower in JIA patients. keywords: activity; adalimumab; age; anti; antibodies; arthritis; cases; children; cohort; conclusion; criteria; data; diagnosis; disease; fever; group; high; inflammation; introduction; involvement; jia; jia patients; joint; juvenile; laboratory; levels; methods; months; mtx; negative; objectives; onset; pain; patients; pediatric; positive; present; pts; report; response; results; rheumatology; sjia; study; symptoms; syndrome; systemic; therapy; treatment; uveitis; years cache: cord-034340-3ksfpaf7.txt plain text: cord-034340-3ksfpaf7.txt item: #86 of 153 id: cord-103625-p55ew8w7 author: Ramana, Chilakamarti V. title: Regulation of early growth response-1 (Egr-1) gene expression by Stat1-independent type I interferon signaling and respiratory viruses date: 2020-08-14 words: 3333 flesch: 34 summary: A shortlist of Egr-1 regulated genes was generated from the TRUUST transcription factor database and published studies in different cell types and under different stimuli (20) (21) (22) 46) . Interrogation of multiple microarray datasets revealed that respiratory viruses including coronaviruses regulated Egr-1 expression in human lung cell lines. keywords: cell; expression; gene; ifn; interferon; lung; response cache: cord-103625-p55ew8w7.txt plain text: cord-103625-p55ew8w7.txt item: #87 of 153 id: cord-252725-e3pazjdi author: Khalil, Ayman title: The upshot of Polyphenolic compounds on immunity amid COVID-19 pandemic and other emerging communicable diseases: An appraisal date: 2020-10-15 words: 8801 flesch: 31 summary: Polydatin has numerous benefits which is widely reported including anti-inflammatory effect in chronic lung diseases, anti-oxidative, anti-platelet aggregative, anti-fibrosis, anti-cancer, benefits for neurological diseases and anxiolytic effects [207, 208] . Anti-asthmatic activity of luteolin was also reported in experimental mice [93] . keywords: acid; activities; activity; anti; antioxidant; compounds; covid-19; diseases; effects; fig; human; infection; inflammation; influenza; lung; respiratory; sars; virus; vitro cache: cord-252725-e3pazjdi.txt plain text: cord-252725-e3pazjdi.txt item: #88 of 153 id: cord-256837-100ir651 author: Smith, Steven B. title: Identification of Common Biological Pathways and Drug Targets Across Multiple Respiratory Viruses Based on Human Host Gene Expression Analysis date: 2012-03-14 words: 8455 flesch: 33 summary: In particular, resistance to different classes of antiviral drugs is becoming more clinically prevalent in respiratory virus infections as seen with RSV and FLU treated with the antiviral drugs palivizumab [7] , and oseltamivir Therefore, more study is needed specifically on the role of caspase and tubulin in host response to respiratory virus infection. keywords: analysis; cells; comparison; datasets; drug; expression; factor; figure; gene; group; host; human; infection; parkin; pathways; protein; response; signaling; table; treatment; viruses cache: cord-256837-100ir651.txt plain text: cord-256837-100ir651.txt item: #89 of 153 id: cord-256838-8rzibpbl author: Eng, Yi Shin title: Unraveling the Molecular Mechanism of Traditional Chinese Medicine: Formulas Against Acute Airway Viral Infections as Examples date: 2019-09-27 words: 9254 flesch: 34 summary: From the viewpoint of pathophysiology, TCM formulas used to manage airway viral infections need to have antiviral activity against such viruses listed above, and/or to induce antiviral cytokines, and/or anti-inflammatory effect, and/or to relieve symptoms commonly presented in airway infections ( Figure 1 ). The ABC Clinical Guide to Herbs Trends in alternative medicine use in the United States, 1990-1997: Results of a follow-up national survey Trends in the use of complementary health approaches among adults: United States Complementary and alternative medicine use among adults and children: United States Current state of phytotherapy in Germany Glycyrrhizic acid inhibits virus growth and inactivates virus particles Antiviral effect of cimicifugin from Cimicifuga foetida against human respiratory syncytial virus Pterodontic Acid Isolated from Laggera pterodonta Inhibits Viral Replication and Inflammation Induced by Influenza A Virus A possible mechanism of interstitial pneumonia during interferon therapy with sho-saiko-to A case of acute eosinophilic pneumonia due to Sho-saiko-to Autoimmune hepatitis with drug-induced pneumonia due to Sho-saiko-to Two cases of pneumonia caused by Sho-saiko-to Acute lymphoblastic leukemia complicated by type C hepatitis during treatment and further by acute interstitial pneumonia due to sho-saiko-to in 7-year-old An autopsy case of interstitial pneumonia probably induced by Sho-saiko-to A case of interstitial pneumonia with chronic hepatitis C following interferon-alfa and sho-saiko-to therapy A comparative study on anticoagulant activities of three Chinese herbal medicines from the genus Panax and anticoagulant activities of ginsenosides Rg1 and Rg2 Brief communication: American ginseng reduces warfarin's effect in healthy patients: A randomized Thrombosis of a prosthetic aortic valve disclosing a hazardous interaction between warfarin and a commercial ginseng product Ginseng and vaginal bleeding Ginseng face cream and unexplained vaginal bleeding Interaction between warfarin and Panax ginseng in ischemic stroke patients Systems biology: Metabonomics Potential role of metabolomics apporoaches in the area of traditional Chinese medicine: As pillars of the bridge between Chinese and Western medicine Application of metabolomics on diagnosis and treatment of patients with psoriasis in traditional Chinese medicine Biomarkers of primary dysmenorrhea and herbal formula intervention: An exploratory metabonomics study of blood plasma and urine Plasma metabolic profiling of normal and dysmenorrhea syndrome rats and the effects of Xiang-Fu-Si-Wu Decoction intervention Adulterants in Asian patent medicines Heavy metal content of ayurvedic herbal medicine products Arsenic and mercury intoxication due to Indian ethnic remedies Lead, mercury, and arsenic in US-and Indian-manufactured Ayurvedic medicines sold via the Internet Risk factors for adverse drug events among nursing home residents Role of Intestinal Microbiota in Baicalin-Induced Drug Interaction and Its Pharmacokinetics Inhibitory Effects of Baicalin on the Expression and Activity of CYP3A Induce the Pharmacokinetic Changes of Midazolam in Rats Herb-drug interactions between Scutellariae Radix and mefenamic acid: Simultaneous investigation of pharmacokinetics, anti-inflammatory effect and gastric damage in rats The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1 Baicalin in radical scavenging and its synergistic effect with beta-carotene in antilipoxidation Studies on the competitive binding of cleviprex and flavonoids to plasma protein by multi-spectroscopic methods: A prediction of food-drug interaction Spectroscopic investigation on the food components-drug interaction: The influence of flavonoids on the affinity of nifedipine to human serum albumin The increased binding affinity of curcumin with human serum albumin in the presence of rutin and baicalin: A potential for drug delivery system Interaction of baicalin with berberine for glucose uptake in 3T3-L1 adipocytes and HepG2 hepatocytes Could the gut microbiota reconcile the oral bioavailability conundrum of traditional herbs? keywords: activities; activity; anti; drug; effects; formulas; herbal; herbs; influenza; interactions; mechanisms; medicine; molecules; patients; tang; tcm; use; virus cache: cord-256838-8rzibpbl.txt plain text: cord-256838-8rzibpbl.txt item: #90 of 153 id: cord-259367-2e998to9 author: Jacques, Alexandre title: Macrophage interleukin-6 and tumour necrosis factor-α are induced by coronavirus fixation to Toll-like receptor 2/heparan sulphate receptors but not carcinoembryonic cell adhesion antigen 1a date: 2009-09-01 words: 6476 flesch: 40 summary: Results indicated that the production of IL-6 and TNF-a was not induced in Tlr2 )/) peritoneal macrophages infected with L2-MHV3 compared with C57BL/6 infected cells (P < 0Á001 for both cytokines) (Fig. 4a,b) . However, it has been reported that incubation of dendritic cells with a specific CEACAM1a mAb (AgB10) promotes the release of various chemokines and cytokines, such as macrophage inflammatory protein (MIP)-1a, MIP-2, IL-6 and IL-12, and increases the expression of the costimulatory molecules CD40, CD54, CD80 and CD86 on these cells. keywords: c57bl/6; ceacam1a; cells; cytokines; il-6; macrophages; mhv3; mice; peritoneal; production; tlr2; tnf cache: cord-259367-2e998to9.txt plain text: cord-259367-2e998to9.txt item: #91 of 153 id: cord-259586-kep2dgaw author: Van Reeth, Kristien title: In vivo studies on cytokine involvement during acute viral respiratory disease of swine: troublesome but rewarding date: 2002-09-10 words: 4197 flesch: 43 summary: This is the reason why most studies have only demonstrated associations between lung cytokines and other parameters, without proving a true cause±effect relationship. This raises questions about the importance of macrophages relative to other lung cells in virus±LPS induced cytokine responses. keywords: cytokines; disease; il-1; il-6; lung; tnf; virus cache: cord-259586-kep2dgaw.txt plain text: cord-259586-kep2dgaw.txt item: #92 of 153 id: cord-262511-96xp1v0r author: Khabar, Khalid S. A. title: Rapid transit in the immune cells: the role of mRNA turnover regulation date: 2007-03-30 words: 6568 flesch: 35 summary: As cities cope with the rapid entry of people by using rapid transit systems, post-transcriptional control of immune system helps in rapid activation of immune cells by mechanisms that involve rapid translocation of mRNA stabilization proteins such as HuR to effector cellular compartments and/or temporal inactivation, e.g., by phosphorylation or proteolysis of RNA decay proteins such as TTP or KSRP. With the coordinated kinetics model, stabilizing RNA-binding proteins such as HuR can occur initially following immune cell activation, allowing rapid and early response of cytokine production. keywords: activation; cell; expression; hur; mrna; p38; protein; regulation; response; stabilization; tnf-; transcriptional; ttp cache: cord-262511-96xp1v0r.txt plain text: cord-262511-96xp1v0r.txt item: #93 of 153 id: cord-267270-r17z4d8x author: Kipar, A. title: Age-related dynamics of constitutive cytokine transcription levels of feline monocytes date: 2005-01-18 words: 2697 flesch: 44 summary: key: cord-267270-r17z4d8x authors: Kipar, A.; Baptiste, K.; Meli, M.L.; Barth, A.; Knietsch, M.; Reinacher, M.; Lutz, H. title: Age-related dynamics of constitutive cytokine transcription levels of feline monocytes date: 2005-01-18 journal: Exp Gerontol DOI: 10.1016/j.exger.2004.12.007 sha: doc_id: 267270 cord_uid: r17z4d8x Monocytes/macrophages are central mediators of inflammation and immunity and therefore of major interest in the study of immunosenescence. However, in order to characterize the effect of age, feline monocyte functions were examined for changes in cytokine transcription levels in early stages of immunosenescence. keywords: age; et al; transcription cache: cord-267270-r17z4d8x.txt plain text: cord-267270-r17z4d8x.txt item: #94 of 153 id: cord-269986-jdcw59r2 author: Regan, Andrew D. title: Activation of p38 MAPK by feline infectious peritonitis virus regulates pro-inflammatory cytokine production in primary blood-derived feline mononuclear cells date: 2009-02-05 words: 5535 flesch: 38 summary: To investigate whether TNFalpha production in FIPV-infected PFBM cells is regulated by p38 MAPK activation, PFBM cells were treated with 10 μM of either SB 203580, SC 409 or 0.1% DMSO for 2 h before inoculating with FIPV-1146 or FIPV-DF2 at an MOI of 100. To determine whether or not FIPVinduced p38 MAPK activation was specific to a single animal, PFBM cells were individually prepared from six additional SPF cats (07PGP2, 07PGV4, 07PGV5, 07FGR2, 07FGV6, 07FJM5). keywords: activation; alpha; cells; feline; fipv; mapk; p38; pfbm; production; tnf cache: cord-269986-jdcw59r2.txt plain text: cord-269986-jdcw59r2.txt item: #95 of 153 id: cord-270414-gh9agf4x author: Fischer, Y. title: Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis date: 2011-10-12 words: 4583 flesch: 50 summary: Cats also received low molecular weight heparin (dalteparid sodium) to minimize the risk of a disseminated intravascular coagulation (DIC), which is often observed in cats with FIP. key: cord-270414-gh9agf4x authors: Fischer, Y.; Ritz, S.; Weber, K.; Sauter‐Louis, C.; Hartmann, K. title: Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis date: 2011-10-12 journal: J Vet Intern Med DOI: 10.1111/j.1939-1676.2011.00806.x sha: doc_id: keywords: cats; days; feline; fip; peritonitis; ppf; study; survival; time; treatment cache: cord-270414-gh9agf4x.txt plain text: cord-270414-gh9agf4x.txt item: #96 of 153 id: cord-271114-hv3gwvdi author: Allam, Gamal title: Neonatal infections in Saudi Arabia: Association with cytokine gene polymorphisms date: 2015-04-22 words: 5568 flesch: 45 summary: Cent Eur J Immunol DOI: 10.5114/ceji.2015.50836 sha: doc_id: 271114 cord_uid: hv3gwvdi In recent years, many studies have reported potential associations between cytokine gene polymorphisms and the development, course, and outcome of sepsis, often with apparently conflicting results. Regarding IL-1β gene polymorphisms, previous studies indicate that SNPs of IL-1β may be associated with a poor prognosis from sepsis keywords: association; eos; gene; genotype; ifn; il-1β; il-6; sepsis; tnf cache: cord-271114-hv3gwvdi.txt plain text: cord-271114-hv3gwvdi.txt item: #97 of 153 id: cord-271812-ldwb05xn author: Prasad, Ananda S. title: Discovery of Human Zinc Deficiency: Its Impact on Human Health and Disease(1)(2)(3) date: 2013-03-01 words: 12241 flesch: 46 summary: Zinc deficiency is also correlated with the risk of respiratory tract infections, but the benefit of supplementation appears to be limited to more severe episodes and in populations with a high incidence of zinc deficiency (57) . The major factor contributing to zinc deficiency is high phytate-containing cereal protein intake in the developing world, and nearly 2 billion subjects may be zinc deficient. keywords: cell; cold; copper; deficiency; diabetes; disease; group; growth; human; insulin; levels; patients; placebo; plasma; protein; subjects; supplementation; zinc; zinc deficiency; zinc supplementation cache: cord-271812-ldwb05xn.txt plain text: cord-271812-ldwb05xn.txt item: #98 of 153 id: cord-272237-gnno6elo author: Wang, Ziran title: A Wearable and Deformable Graphene-Based Affinity Nanosensor for Monitoring of Cytokines in Biofluids date: 2020-07-31 words: 4475 flesch: 47 summary: To date, efforts have been made to use GFET biosensors in wearable applications due to the high mechanical flexibility of graphene [15] [16] To date, efforts have been made to use GFET biosensors in wearable applications due to the high mechanical flexibility of graphene [15] [16] keywords: artificial; biosensor; detection; graphene; tears; tnf cache: cord-272237-gnno6elo.txt plain text: cord-272237-gnno6elo.txt item: #99 of 153 id: cord-272695-wmzq4lkh author: Ahmed, Ahmed A. title: TNF-α − 308 G/A and IFN-γ + 874 A/T gene polymorphisms in Saudi patients with cutaneous leishmaniasis date: 2020-05-13 words: 3820 flesch: 48 summary: This study was undertaken to test the association of TNF-α − 308 and IFN-γ + 874 gene polymorphisms with the susceptibility of Leishmania (L) species among CL patients in central region of Saudi Arabia. Furthermore, an association of TNF-αor IFN-γ with the increase of tissue damage or ulceration was also reported in CL patients [8] . keywords: ifn; patients; saudi; tnf cache: cord-272695-wmzq4lkh.txt plain text: cord-272695-wmzq4lkh.txt item: #100 of 153 id: cord-275413-e2rhioty author: Rowland, Raymond R.R. title: The interaction between PRRSV and the late gestation pig fetus date: 2010-09-09 words: 6192 flesch: 42 summary: The IHC staining procedure included two sets of negative controls: tissue thin sections from non-infected fetuses and from infected fetuses stained with only secondary antibody. This scenario as a cause of severe interstitial pnuemonia in the PRRSV-infected newborn requires further investigation, but has obvious implications in the etiology of postnatal pulmonary complications following virus infections of the fetus. keywords: cells; fetuses; ifn-; infection; lymph; pcr; porcine; prrsv; syndrome; virus cache: cord-275413-e2rhioty.txt plain text: cord-275413-e2rhioty.txt item: #101 of 153 id: cord-275730-650sjwyy author: Gogoi, Himanshu title: The Age of Cyclic Dinucleotide Vaccine Adjuvants date: 2020-08-13 words: 8383 flesch: 45 summary: In addition to DCs, tumor cells themselves are induced to contribute to the production of IFN-β Type I IFNs then activate the NK cell to kill tumor cells keywords: cdg; cdn; cdns; cells; cgamp; ifns; lung; mice; mucosal; production; responses; sting; tumor; type; vaccine; vivo cache: cord-275730-650sjwyy.txt plain text: cord-275730-650sjwyy.txt item: #102 of 153 id: cord-276564-o21ncldx author: Miller, R. title: COVID-19: NAD(+) deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity date: 2020-06-29 words: 3232 flesch: 31 summary: (39) COVID-19 replication and SIRT1 SIRT1 not only controls and modifies the inflammatory response, but along with the Sirtuin family (SIRT1-7) is also a primary defence against DNA and RNA viral pathogens. COVID-19: NAD + deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity We hypothesize that reduced Nicotinamide Adenine Dinucleotide (NAD + ) levels with consequent deficient activity of the NAD + dependent molecule SIRT1, which modulates cytokine production, may be the factor that predisposes the aged, obese, type 2 diabetics and other vulnerable groups to an increased mortality. keywords: covid-19; disease; mortality; nad; sirt1; stress; tnf cache: cord-276564-o21ncldx.txt plain text: cord-276564-o21ncldx.txt item: #103 of 153 id: cord-278339-6ddsj014 author: Gianfrancesco, Milena title: Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry date: 2020-05-29 words: 5391 flesch: 34 summary: Age, sex, smoking status, rheumatic disease diagnosis, comorbidities and rheumatic disease medications taken immediately prior to infection were analysed. key: cord-278339-6ddsj014 authors: Gianfrancesco, Milena; Hyrich, Kimme L; Al-Adely, Sarah; Carmona, Loreto; Danila, Maria I; Gossec, Laure; Izadi, Zara; Jacobsohn, Lindsay; Katz, Patricia; Lawson-Tovey, Saskia; Mateus, Elsa F; Rush, Stephanie; Schmajuk, Gabriela; Simard, Julia; Strangfeld, Anja; Trupin, Laura; Wysham, Katherine D; Bhana, Suleman; Costello, Wendy; Grainger, Rebecca; Hausmann, Jonathan S; Liew, Jean W; Sirotich, Emily; Sufka, Paul; Wallace, Zachary S; Yazdany, Jinoos; Machado, Pedro M; Robinson, Philip C title: Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry date: 2020-05-29 journal: keywords: anti; cases; covid-19; data; disease; fees; hospitalisation; inhibitors; patients; registry; use cache: cord-278339-6ddsj014.txt plain text: cord-278339-6ddsj014.txt item: #104 of 153 id: cord-279498-ez3yq7xi author: Suzumura, Akio title: Immune Response in the Brain: Glial Response and Cytokine Production date: 2008-12-31 words: 5324 flesch: 42 summary: I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effect on antigen presentation MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: Induction of Ia antigen expression by gamma-interferon Immunohistochemical analysis of the rat central nervous system during experimental allergic encephalomyelitis, with special reference to Ia positive cells with dendritic morphology An immunoelectron microscopical study of class II major hsitocompatibility complex during chronic relapsing experimental allergic encephalomyelitis in Biozzi AB/H mice Microglial involvement in autoimmune inflammation of the central and peripheral nervous system Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motoneuron injury Induction of MHC class II antigen expression on murine microglia by interleukin-3 Rat microglial interleukin-3 In situ hybridization histochemistry localization of interleukin-3 mRNA in mouse brain Production of granulocyte/macrophage colony stimulating factor by cultured astrocytes Effects of colony stimulating factors on isolated microglia Morphological transformation of microglia in vitro Transforming growth factor beta suppresses activation and proliferation of microglia in vitro IL-4 induces proliferation and activation of microglia but suppressed their induction of class II major histocompatibility complex antigen expression Production of interleukin-10 by mouse glial cells in culture Macrophage-, and astrocyte-derived transforming growth factor beta as a mediator of central nervous system dysfunction in acquired immunodeficiency syndrome Differential expression of transforming growth factor beta1,2, and 3 by glioblastoma cells, astrocytes, and microglia Expression of cytokine receptors in cultured neuronal and glial cells Corona virus infection induces H-2 antigen expression on oligodendrocytes and astrocytes Viral particles induce Ia antigen expression on astrocytes Interleukin-1 of the central nervous system is produced by ameboid microglia On the cellular source and function of interleukin-6 produced in the central nervous system in viral diseases Production of tumor necrosis factor alpha by microglia and astrocytes in culture TNFa induces IL-6 production by astrocytes but not by microglia Production of interleukin-5 by mouse astrocytes and microglia in culture Production of interleukin-12 and the expression of its receptors by murine microglia IFNs are critical regulators of IL-1 receptor antagonist and IL-1 expression in human microglia Murine microglial cells produce and respond to interleukin-18 Production of interferon-g by microglia Production of IL-27 and IL-12 family cytokines by microglia and their subpopulations Cytokine network in the central nervous system and its roles in growth and differentiation of glial and neuronal cells Induction of functional IL-2 receptor in mouse microglia Proliferation of astroglia and oligodendroglia in response to human T cell-derived factors Cytokines, chemokines, and cytokine receptors in human microglia IL-12 production by central nervous system microglia is inhibited by astrocytes African trypanosomes activate human fetal brain cells to proliferation and IFN-g production IFN-a production by antigen presenting cells: Mechanisms emerge Astrocytes present myelin basic protein to encephalitogenic T-cell lines Expression of Ia molecules by astrocytes during acute experimental allergic encephalomyelitis in the Lewis rat Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo Antigen presentation and tumor cytotoxicity by interferon-gamma-treated microglial cells Immune regulation by brain cells in the central nervous system; microglia but not astrocytes present myelin basic protein to encephalitogenic T-cells under in vivo-mimicking conditions Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting The costimulatory molecule B7 is expressed in human microglia in culture and multiple sclerosis acute lesions T-cell costimulatory molecules B71 (CD80) and B7-2 (CD86) are expressed in human microglia but not in astrocytes in culture Analysis of B7-1 and B7-2 costimulatory ligands in cultured mouse microglia: Upregulation by interferon-gamma and lipopolysaccharide and downregulation by interleukin-10, prostaglandin E2 and cyclic AMP-elevating agents Antigen-specific damage to brain vascular endothelial cells mediated by encephalitogenic and nonencephalitogenic CD4 T cell lines in vitro Antigen presentation by brain microvessel smooth muscle and endothelium Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro Cultures of astrocytes and microglia express interleukin 18 Caspase-1 expression in multiple sclerosis plaques and cultured glial cells CCR5(+) and CXCR3(+) Glial cells have also been shown to produce various cytokines and chemokines. keywords: antigen; astrocytes; cells; class; cytokines; expression; mhc; microglia; production; tnf cache: cord-279498-ez3yq7xi.txt plain text: cord-279498-ez3yq7xi.txt item: #105 of 153 id: cord-280599-7ixpqd5n author: OPENSHAW, P J M title: What does the peripheral blood tell you in SARS? date: 2004-04-01 words: 1227 flesch: 42 summary: Possibly, the best we can expect is that finding some combination of cytokine levels might allow earlier diagnosis; in the case of SARS, its differentiation from community acquired pneumonia, influenza or other causes of fever which require quite different approaches to patient management. So, what can we expect to learn by profiling cytokine production or levels in blood samples from patients with inflammatory diseases? keywords: cytokine; patients; tnf cache: cord-280599-7ixpqd5n.txt plain text: cord-280599-7ixpqd5n.txt item: #106 of 153 id: cord-282242-5tkhjiwl author: Gómez-Laguna, J. title: Cytokine Expression by Macrophages in the Lung of Pigs Infected with the Porcine Reproductive and Respiratory Syndrome Virus date: 2009-08-19 words: 3817 flesch: 43 summary: key: cord-282242-5tkhjiwl authors: Gómez-Laguna, J.; Salguero, F.J.; Barranco, I.; Pallarés, F.J.; Rodríguez-Gómez, I.M.; Bernabé, A.; Carrasco, L. title: Cytokine Expression by Macrophages in the Lung of Pigs Infected with the Porcine Reproductive and Respiratory Syndrome Virus date: 2009-08-19 journal: J Comp Pathol DOI: 10.1016/j.jcpa.2009.07.004 sha: doc_id: 282242 cord_uid: 5tkhjiwl Porcine reproductive and respiratory syndrome (PRRS) is caused by a virus that predominantly replicates in alveolar macrophages. All of these cytokines were expressed mainly by septal macrophages with weaker expression by alveolar macrophages, lymphocytes and neutrophils. keywords: cytokines; expression; ifn; il-10; lung; macrophages; prrsv; tnf cache: cord-282242-5tkhjiwl.txt plain text: cord-282242-5tkhjiwl.txt item: #107 of 153 id: cord-283246-dj7teo89 author: Otsuka, Ryo title: Macrophage activation syndrome and COVID-19 date: 2020-08-06 words: 3233 flesch: 34 summary: Thus, serum levels of these cytokines are often at a high level in MAS patients [5] . In this context, cytokines highly produced in MAS patients are potential candidates, and some clinical reports provided promising results by cytokine-targeting therapy. keywords: activation; covid-19; il-6; macrophage; mas; patients; syndrome; tnf; treatment cache: cord-283246-dj7teo89.txt plain text: cord-283246-dj7teo89.txt item: #108 of 153 id: cord-291076-p350i54m author: Wang, Renxi title: The role of C5a in acute lung injury induced by highly pathogenic viral infections date: 2015-05-06 words: 5804 flesch: 34 summary: The complement-activated product C5a is a strong chemoattractant and is involved in the recruitment of inflammatory cells such as neutrophils, eosinophils, monocytes, and T lymphocytes, in activation of phagocytic cells and release of granulebased enzymes and generation of oxidants. In lung fibroses, inflammatory cells produce a significantly greater amount of ROS. keywords: acute; ali; c5a; cells; complement; cytokines; h5n1; infection; influenza; injury; lung; role; virus cache: cord-291076-p350i54m.txt plain text: cord-291076-p350i54m.txt item: #109 of 153 id: cord-295523-5pv7kw6i author: Picchianti Diamanti, Andrea title: Cytokine Release Syndrome in COVID-19 Patients, A New Scenario for an Old Concern: The Fragile Balance between Infections and Autoimmunity date: 2020-05-08 words: 7916 flesch: 31 summary: SARS patients with a more severe disease displayed higher serum levels of pro-inflammatory cytokines (IFN-γ, IL-1, IL-6) and chemokines (including IL-8) Indeed, in CRS patients, infections principally involve the respiratory tract. keywords: activation; anti; arthritis; cells; cov-2; covid-19; crs; cytokine; disease; il-6; infection; patients; response; sars; syndrome; tnf; treatment cache: cord-295523-5pv7kw6i.txt plain text: cord-295523-5pv7kw6i.txt item: #110 of 153 id: cord-295683-eoxxal8v author: Gong, R. title: Hepatocyte growth factor suppresses acute renal inflammation by inhibition of endothelial E-selectin date: 2006-04-01 words: 4491 flesch: 35 summary: 10 Both E-and P-selectins are expressed by endothelial cells; L-selectin is found only on leukocytes. These data suggest that the PI3K-Akt pathway mediates HGF's suppression of E-selectin in endothelial cells. keywords: adhesion; akt; cells; endothelial; expression; gsk3b; hgf; inflammation; pi3k; selectin; tnf cache: cord-295683-eoxxal8v.txt plain text: cord-295683-eoxxal8v.txt item: #111 of 153 id: cord-295745-iw3ftw3h author: Gershoni, Jonathan M title: Molecular decoys: antidotes, therapeutics and immunomodulators date: 2008-11-18 words: 5555 flesch: 37 summary: Soluble decoy receptors are not always antagonistic to their ligands as is illustrated by soluble IL-6 receptor (sIL-6R). Decoy receptor 3 (DcR3) keywords: anti; binding; cancer; cell; decoys; factor; inflammation; membrane; receptors; soluble; tnf; toxin; treatment; type; virus cache: cord-295745-iw3ftw3h.txt plain text: cord-295745-iw3ftw3h.txt item: #112 of 153 id: cord-297128-s5c9h4lm author: Hong, Joung-Woo title: Anti-inflammatory activity of cinnamon water extract in vivo and in vitro LPS-induced models date: 2012-11-28 words: 3863 flesch: 47 summary: In vivo LPS injection CWE (20, 100 or 500 mg/kg of body weight) was given to mice via oral gavage for 6 days. Twenty microliters of each fraction or total CWE in 1.58 ml of water was incubated with 100 μl of FC reagent (Sigma) for 5 min at room temperature. keywords: cinnamon; cwe; fraction; iκbα; lps; macrophages; tnf; water cache: cord-297128-s5c9h4lm.txt plain text: cord-297128-s5c9h4lm.txt item: #113 of 153 id: cord-297857-ybqj8z1r author: Petagna, L. title: Pathophysiology of Crohn’s disease inflammation and recurrence date: 2020-11-07 words: 6664 flesch: 31 summary: Regional ileitis Medical management of postoperative recurrence in Crohn's disease Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial Immunopathology of inflammatory bowel disease Chemokines in inflammatory bowel disease Intestinal inflammation: a complex interplay of immune and nonimmune cell interactions Interleukin-21 sustains inflammatory signals that contribute to sporadic colon tumorigenesis Ischemic preconditioning protects intestine from prolonged ischemia Immunopathogenesis of IBD: current state of the art IL-15 positively regulates IL-21 production in celiac disease mucosa Interleukin-34 sustains pro-tumorigenic signals in colon cancer tissue Inflammatory bowel disease position statement of the Italian Society of Colorectal Surgery (SICCR): Crohn's disease Interleukin-25 production is differently regulated by TNF-α and TGF-β1 in the human gut TNF-alpha producing innate lymphoid cells (ILCs) are increased in active celiac disease and contribute to promote intestinal atrophy in mice Targeting immune cell circuits and trafficking in inflammatory bowel disease Plasma cells in the mucosa of patients with inflammatory bowel disease produce granzyme B and possess cytotoxic activities Genome and pan-genome analysis to classify emerging bacteria Identification of city specific important bacterial signature for the MetaSUB CAMDA challenge microbiome data Integration of molecular features with clinical information for predicting outcomes for neuroblastoma patients Unraveling bacterial fingerprints of city subways from microbiome 16S gene profiles Antibiotic resistance and metabolic profiles as functional biomarkers that accurately predict the geographic origin of city metagenomics samples Application of machine learning techniques for creating urban microbial fingerprints Assessment of urban microbiome assemblies with the help of targeted in silico gold standards Darwinian selection of host and bacteria supports emergence of Lamarckian-like adaptation of the system as a whole P314 C-reactive protein is associated with depression and anxiety in patients with inflammatory bowel disease ECCO guidelines on therapeutics in Crohn's disease: medical treatment Impact of surgery on quality of life in Crohn's disease: short-and mid-term followup Systematic review with network meta-analysis: comparative efficacy and safety of budesonide and mesalazine (mesalamine) for Crohn's disease Antibiotic therapy in inflammatory bowel disease: a systematic review and meta-analysis Comparative effectiveness of Mesalamine, sulfasalazine, corticosteroids, and budesonide for the induction of remission in Crohnʼs disease Recomendaciones del Grupo Español de Trabajo en Enfermedad de Crohn y colitis Ulcerosa (GETECCU) sobre el uso de tiopurinas en la enfermedad inflamatoria intestinal The safety and tolerability of methotrexate for treating patients with Crohnʼs disease Systematic review with network meta-analysis: the efficacy of anti-TNF agents for the treatment of Crohn's disease Vedolizumab for the treatment of Crohn's disease Ustekinumab in the management of Crohn's disease: expert opinion Evolution of surgery for Crohnʼs disease An appraisal of the long-term results of surgical treatment of regional ileitis Carcinoma complicating Crohn's disease Cancer in Crohn's disease after diversionary surgery Multi-omics integration for neuroblastoma clinical endpoint prediction Effect of resection margins on the recurrence of Crohn's disease in the small bowel Recurrent Crohn's disease and resection margins: bigger is not better Stricture-plasty for tubercular strictures of the gastro-intestinal tract Minimal surgery for chronic obstruction in patients with extensive or universal Crohn's disease Inflammatory bowel disease position statement of the Italian Society of Colorectal Surgery (SICCR): ulcerative colitis A comprehensive review of Strictureplasty techniques in Crohn's disease: types, indications, comparisons, and safety Two surgical procedures for strictures at Finney Strictureplasty for small bowel Crohn's disease How I do it: side-to-side Isoperistaltic Strictureplasty for extensive Crohn's disease Postoperative change of mucosal inflammation at Strictureplasty segment in Crohn's disease: cytokine production and endoscopic and histologic findings Sideto-side Isoperistaltic Strictureplasty in extensive Crohn's disease Modified side-to-side Isoperistaltic Strictureplasty over the Ileocaecal valve: an alternative to Ileocaecal resection in extensive terminal Ileal Crohn's disease Michelassi II Strictureplasty for Crohnʼs disease Gastrointestinal cancer surgery and enhanced recovery after surgery (ERAS) during COVID-19 outbreak Minimal open access Ileocolic resection in complicated Crohn's disease of the terminal ileum Comparative study of laparoscopic vs open gastrectomy in gastric cancer management Inflammatory bowel disease (IBD) position statement of the Italian Society of Colorectal Surgery (SICCR): general principles of IBD management Surgery for inflammatory bowel disease in the era of laparoscopy Laparoscopic versus open Ileo-colonic resection in Crohn's disease: shortand long-term results from a prospective longitudinal study Pathogenesis of postoperative recurrence in Crohn's disease Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum Predictability of the postoperative course of Crohn's disease Ambulatory management of perianal Crohn's disease during the COVID-19 pandemic Early post-operative endoscopic recurrence in Crohn's disease patients: data from an Italian group for the study of inflammatory bowel disease (IG-IBD) study on a large prospective multicenter cohort Recomendaciones del Grupo Español de Trabajo en Enfermedad de Crohn y colitis Ulcerosa (GETECCU) Patients can develop one or more of these disease behavior and they often tend to evolve from inflammatory to penetrating or stricturing disease [25] . keywords: anastomosis; bowel; cells; crohn; disease; end; fat; immune; inflammation; mesentery; patients; recurrence; resection; role; surgery cache: cord-297857-ybqj8z1r.txt plain text: cord-297857-ybqj8z1r.txt item: #114 of 153 id: cord-300991-ipy24zxp author: Khan, Amira Sayed title: Obesity and COVID-19: Oro-Naso-Sensory Perception date: 2020-07-08 words: 5986 flesch: 41 summary: There is no direct report available on the loss of these chemical senses in obese COVID-19 patients. Epidemiological data confirm that there is an increased rate of pneumonia and RTI in COVID-19 obese patients [12] . keywords: cells; cov-2; covid-19; infection; inflammation; loss; obese; obesity; olfactory; patients; sars; taste; tnf cache: cord-300991-ipy24zxp.txt plain text: cord-300991-ipy24zxp.txt item: #115 of 153 id: cord-301102-jbjysyqm author: Priestnall, Simon L. title: Quantification of mRNA encoding cytokines and chemokines and assessment of ciliary function in canine tracheal epithelium during infection with canine respiratory coronavirus (CRCoV) date: 2009-01-15 words: 6031 flesch: 40 summary: The development of an accurate method for the quantification of CRCoV in tissue samples enabled nucleocapsid gene RNA to be quantified in cDNA from canine tracheal cultures inoculated with CRCoV. The mean CRCoV nucleocapsid gene copy number within tracheal cultures from different dogs at 24-96 h post-inoculation was determined (Fig. 4) . Production of plasmid standards for real-time quantitative RT-PCR The following cytokines were selected for mRNA quantification in canine tracheal cultures; TNF-a, IL-6 and IL-8. keywords: canine; cells; crcov; cultures; cytokine; inoculation; levels; mrna; respiratory; tracheal cache: cord-301102-jbjysyqm.txt plain text: cord-301102-jbjysyqm.txt item: #116 of 153 id: cord-301946-erzh30mt author: Kwak-Kim, Joanne title: COVID-19 and immunomodulation treatment for women with reproductive failures date: 2020-06-12 words: 5611 flesch: 27 summary: Gonzalez et al. 2018 , Liu et al. 2018 . It is a calcineurin inhibitor that suppresses the production of IL-2 and thus, inhibits the development and proliferation of T cells (Kay et al. 1989 ). keywords: cells; coronavirus; covid-19; et al; immune; infection; patients; pregnancy; sars; tnf; treatment; women cache: cord-301946-erzh30mt.txt plain text: cord-301946-erzh30mt.txt item: #117 of 153 id: cord-302258-derq9b27 author: Zhang, Hui title: Effects of ubiquitin-proteasome inhibitor on the expression levels of TNF-α and TGF-β1 in mice with viral myocarditis date: 2019-08-14 words: 3457 flesch: 47 summary: After sectioning, the pathological changes of mouse myocardial tissues were observed under light microscope (Olympus Corp.) and the pathological score of the myocardial tissues was evaluated. Correlation between mouse myocardial histopathologic scores and expression of protein of TNF-α and TGF-β1 in myocardial tissues, as well as the expression of TNF-α and TGF-β1 in myocardial tissue in VMC mice was analyzed. keywords: group; mice; tgf; tissues; tnf; vmc cache: cord-302258-derq9b27.txt plain text: cord-302258-derq9b27.txt item: #118 of 153 id: cord-306577-gq6fss5l author: Hsueh, Wei title: Neonatal Necrotizing Enterocolitis: Clinical Considerations and Pathogenetic Concepts date: 2002-11-11 words: 8425 flesch: 37 summary: Intestinal PAF concentrations were elevated (270 Ϯ 80 pg/g) in animals stressed with asphyxia, formula feeding, and bacterial inoculation compared with age-matched, healthy, maternally fed controls (70 Ϯ 50 pg/g, P Ͻ 0.05). Injection of PAF induces intestinal necrosis, and PAF antagonists prevent the bowel injury induced by bacterial endotoxin, hypoxia, or challenge with tumor necrosis factor-a (TNF) plus endotoxin in adult rats. keywords: bowel; enterocolitis; factor; injury; intestine; lps; nec; necrosis; necrotizing; neonatal; paf; platelet; rat; role; tnf cache: cord-306577-gq6fss5l.txt plain text: cord-306577-gq6fss5l.txt item: #119 of 153 id: cord-306983-6w2fvtfy author: Wang, Siye title: Influenza Virus—Cytokine-Protease Cycle in the Pathogenesis of Vascular Hyperpermeability in Severe Influenza date: 2010-10-01 words: 3817 flesch: 34 summary: A possible activator of the viral fusion glycoprotein Activation of influenza A viruses by trypsin treatment Trypsin action on the growth of Sendai virus in tissue culture cells: structural difference of Sendai viruses grown in eggs and tissue culture cells Identification of biological activity of paramyxovirus glycoprotein: activation of cell fusion, hemolysis and infectivity by proteolytic cleavage of an inactive precursor protein of Sendai virus The molecular of influenza virus pathogenicity Proteases essential for human influenza virus entry into cells and their inhibitors as potential therapeutic agents Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses Human matrix metalloproteinase-9: activation by limited trypsin treatment and generation of monoclonal antibodies specific for the activated form Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis Basement membrane and matrix metalloproteinases in monocrotaline-induced liver injury Neuropathogenesis of influenza virus infection in mice Persistence of viral RNA in the brain of offspring to mice infected with influenza A/WSN/33 virus during pregnancy Treatment with inhibitors of the NF-kB pathway improves whole body tension development in the mdx mouse These findings suggest that cytokines upregulate trypsin in vascular endothelial cells and that secreted trypsin plays an (original magnification, ϫ200) . keywords: brain; cells; cytokines; figure; human; infection; influenza; tnf; trypsin; vascular; virus cache: cord-306983-6w2fvtfy.txt plain text: cord-306983-6w2fvtfy.txt item: #120 of 153 id: cord-307813-elom30nx author: Yip, Tsz-Fung title: Advancements in Host-Based Interventions for Influenza Treatment date: 2018-07-10 words: 15110 flesch: 27 summary: Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency Disease-promoting effects of type I interferons in viral, bacterial, and coinfections Protection from lethal influenza virus challenge by oral type 1 interferon Low-dose oral interferon alpha as prophylaxis against viral respiratory illness: a double-blind, parallel controlled trial during an influenza pandemic year IFNlambda is a potent anti-influenza therapeutic without the inflammatory side effects of IFNalpha treatment Pathogenic potential of interferon alphabeta in acute influenza infection The superiority of IFN-lambda as a therapeutic candidate to control acute influenza viral lung infection Type I interferon induction during influenza virus infection increases susceptibility to secondary Streptococcus pneumoniae infection by negative regulation of gammadelta T cells Interferon-lambda mediates non-redundant front-line antiviral protection against influenza virus infection without compromising host fitness RIG-I activation protects and rescues from lethal influenza virus infection and bacterial superinfection Antiviral effect of a selective COX-2 inhibitor on H5N1 infection in vitro Avian influenza A H7N9 virus induces severe pneumonia in mice without prior adaptation and responds to a combination of zanamivir and COX-2 inhibitor Role of cyclooxygenase-2 in H5N1 viral pathogenesis and the potential use of its inhibitors Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages Modified Jiu Wei Qiang Huo decoction improves dysfunctional metabolomics in influenza A pneumoniainfected mice Pattern recognition receptors and inflammation Cutting edge: There is an urgent need to search for alternative targets to treat influenza virus infections, including non-viral targets such as host cellular factors; which are promising as viruses rely on the host machinery for replication. keywords: addition; antiviral; cells; complex; drug; export; host; human; iav; immune; infected; infection; influenza; inhibitor; lung; membrane; mice; nuclear; production; protein; replication; role; treatment; type; viral; virus; viruses; vitro; vrnp cache: cord-307813-elom30nx.txt plain text: cord-307813-elom30nx.txt item: #121 of 153 id: cord-308008-s2t11l3h author: Limonta, Daniel title: Apoptotic mediators in patients with severe and non‐severe dengue from Brazil date: 2013-10-29 words: 6079 flesch: 44 summary: Multicentre prospective study on dengue classification in four South-east Asian and three Latin American countries Survivin and IAP proteins in cell-death mechanisms Differential proinflammatory and angiogenesis-specific cytokine production in human pulmonary endothelial cells, HPMEC-ST1.6R infected with dengue-2 and dengue-3 virus Different innate signatures induced in human monocyte-derived dendritic cells by wild-type dengue 3 virus, attenuated but reactogenic dengue 3 vaccine virus, or attenuated nonreactogenic dengue 1-4 vaccine virus strains Serotype-specific differences in clinical manifestations of dengue Usefulness and applicability of the revised dengue case classification by disease: Multi-centre study in 18 countries Gene expression profiling of dengue infected human primary cells identifies secreted mediators in vivo The global distribution and burden of dengue Pathological survivin expression links viral infections with pathogenesis of erosive rheumatoid arthritis Survivin -31C/G polymorphism and gastric cancer risk in a Brazilian population Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity Detection of circulant tumor necrosis factor-alpha, soluble tumor necrosis factor p75 and interferon-gamma in Brazilian patients with dengue fever and dengue hemorrhagic fever Proinflammatory factors present in sera from patients with acute dengue infection induce activation and apoptosis of human microvascular endothelial cells: Possible role of TNF-alpha in endothelial cell damage in dengue Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage Expression of TNF-related apoptosis-inducing ligand (TRAIL) in megakaryocytes and platelets Mechanisms of HIV-associated lymphocyte apoptosis Regulation of inflammatory chemokine receptors on blood T cells associated to the circulating versus liver chemokines in dengue fever TNF-alpha-308A allele, a possible severity risk factor of hemorrhagic manifestation in dengue fever patients Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death Dengue virus activates membrane TRAIL relocalization and IFN-alpha production by human plasmacytoid dendritic cells in vitro and in vivo Dengue: A continuing global threat Proinflammatory response during Ebola virus infection of primate models: Possible involvement of the tumor necrosis factor receptor superfamily The early whole-blood transcriptional signature of dengue virus and features associated with progression to dengue shock syndrome in Vietnamese children and young adults Serum levels of tumor necrosis factor-alpha (TNFalpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta) in dengue-infected patients Cell death Liver histopathology and biological correlates in five cases of fatal dengue fever in Vietnamese children Isolation of a Singh's Aedes albopictus cell clone sensitive to Dengue and Chikungunya viruses Characteristics of dengue virus-infected peripheral blood mononuclear cell death that correlates with the severity of illness Association of intracellular T(H)1-T(H)2 balance in CD4þ T-cells and MIP-1alpha in CD8þ T-cells with disease severity in adults with dengue Antibody-dependent enhancement of dengue virus growth in human monocytes as a risk factor for dengue hemorrhagic fever TRAIL receptor I (DR4) polymorphisms C626G und A638C are associated with an increased risk for hepatocellular carcinoma (HCC) in HCV-infected patients Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction Plasma levels of tumour necrosis factor alpha and transforming growth factor beta-1 in children with dengue 2 virus infection in French Polynesia Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells Increment of interleukin 6, tumour necrosis factor alpha, nitric oxide, C-reactive protein and apoptosis in dengue Therefore, plasma levels of the three proapoptotic mediators Fas ligand (FasL), tumor necrosis factor‐α (TNF‐α), and TNF‐related apoptosis‐inducing ligand (TRAIL) were measured in dengue patients. keywords: apoptosis; cells; dengue; et al; levels; patients; signs; study; survivin; tnf; trail; virus; warning cache: cord-308008-s2t11l3h.txt plain text: cord-308008-s2t11l3h.txt item: #122 of 153 id: cord-308433-vrkdtrfz author: Roberts, Ceri A. title: TNF Blockade Maintains an IL-10(+) Phenotype in Human Effector CD4(+) and CD8(+) T Cells date: 2017-02-15 words: 7323 flesch: 41 summary: TNF blockade also regulated IL-10 expression in CD4 + T cells upon antigenic stimulation. It was shown both cross-sectionally and longitudinally that inflammatory arthritis patients on TNFi therapy have an increased frequency of peripheral blood (PB) IL-10 + CD4 + T cells. keywords: anti; blockade; cd4; cells; expression; frequencies; il-10; t cells; tnf cache: cord-308433-vrkdtrfz.txt plain text: cord-308433-vrkdtrfz.txt item: #123 of 153 id: cord-309171-kgc7lgjp author: Dolinger, Michael T. title: Pediatric Crohn's Disease and Multisystem Inflammatory Syndrome in Children (MIS-C) and COVID-19 Treated with Infliximab date: 2020-05-21 words: 1278 flesch: 40 summary: Management of Patients with Crohn's Disease and Ulcerative Colitis During the COVID-19 Pandemic: Results of an International Meeting Chemokine and cytokine levels in inflammatory bowel disease patients Increased production of tumour necrosis factor-alpha interleukin 1-beta, and interleukin 6 by morphologically normal intestinal biopsies from patients with Crohn's disease Clinical and immunological features of severe and moderate coronavirus disease 2019 Tocilizumab, an anti-IL6 receptor antibody, to treat COVID-19 related respiratory failure: a case report Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed but not TNF Antagonists, are Associated with Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases: Results from an International Registry Inflammatory disease overlap possibly contributed to cytokine storm and MIS-C. Cytokine storm has been found to be a major cause of morbidity in patients with severe COVID-19 infection. keywords: covid-19; disease; tnf cache: cord-309171-kgc7lgjp.txt plain text: cord-309171-kgc7lgjp.txt item: #124 of 153 id: cord-309619-glb2y82u author: Domingo, Pere title: The four horsemen of a viral Apocalypse: The pathogenesis of SARS-CoV-2 infection (COVID-19) date: 2020-07-29 words: 9372 flesch: 35 summary: Front Immunol 2020 Relationships among lymphocyte subsets, cytokines, and the pulmonary inflammation index in coronavirus (COVID-19) infected patients Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice Adaptive immune cells temper initial innate responses Clinical characteristics of coronavirus disease 2019 in China Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients Middle east respiratory syndrome coronavirus (MERS-CoV): infection, immunological response, and vaccine development Bcl-xL inhibits T-cell apoptosis induced by expression of SARS coronavirus E protein in the absence of growth factors SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion Cell pyroptosis, a potential pathogenic mechanism of 2019-nCoV Infection (2020) Severe acute respiratory syndrome coronavirus Viroporin 3a activates the NLRP3 inflammasome Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals The potential danger of suboptimal antibody responses in COVID-19 The ACE2/Angiotensin-(1-7)/MAS axis of the renin-angiotensin system: focus on angiotensin Kidneys and fluids in pressure regulation. COVID-19 patients have high serum levels of inflammatory cytokines, including interleukin (IL)-2, IL-7, IL-10, granulocyte-colony stimulating factor (G-CSF), interferon gamma-induced protein (IP)-10, monocyte chemoattractant protein (MCP)-1, macrophage SARS-CoV-2 infects primarily type II pneumocytes through binding to the ACE2 receptor. keywords: ace2; acute; angiotensin; cells; converting; coronavirus; cov-2; covid-19; disease; expression; immune; infection; inflammatory; lung; patients; protein; receptor; response; role; sars; syndrome cache: cord-309619-glb2y82u.txt plain text: cord-309619-glb2y82u.txt item: #125 of 153 id: cord-310942-191m0e65 author: Boga, Jose Antonio title: Beneficial actions of melatonin in the management of viral infections: a new use for this “molecular handyman”? date: 2012-04-18 words: 7229 flesch: 26 summary: A second mechanism is the triggering of effector functions of cellular components of the innate immune system, such as granulocytes, natural killer cells (NK) and natural killer T cells (NKT cells), macrophages, and dendritic cells, which are normally rapidly recruited and/or activated at the site of virus infection, causing a local inflammation [125] . Transactions of the The biological properties of interleukin-1 Resistance of interleukin-1 beta-deficient mice to fatal Sindbis virus encephalitis Thermal and behavioural effects of lipopolysaccharide and influenza in interleukin-1 beta deficient mice Vaccinia and cowpox viruses encode a novel secreted interleukin-1-binding protein Arachidonic acid lipoxygenation may mediate interleukin-1 stimulation of nerve growth factor secretion in astroglial cultures Modulation by tumor necrosis factor-a of human astroglial cell production of granulocyte-macrophage colony stimulating factor (G-CSF) Cytokine-regulated adhesion between encephalitogenic T lymphocytes and cerebrovascular endothelial cells A novel role for melatonin: regulation of the expression of cell adhesion molecules in the rat hippocampus and cortex Recognition of doublestranded RNA and activation of NF-jB by Toll-like receptor 3 Identification of NF-kappaB-dependent gene networks in respiratory syncytial virusinfected cells Melatonin decreases TLR3-mediated inflammatory factor expression via inhibition of NFkappa B activation in respiratory syncytial virus-infected RAW264.7 macrophages Role of virus-induced apoptosis in a host defense mechanism against virus infection Enter the kill zone: initiation of death signaling during virus entry Melatonin and cell death: differential actions on apoptosis in normal and cancer cells Melatonin prevents capacitation and apoptotic-like changes in ram spermatozoa and increases fertility Melatonin leucocyte apoptosis induced by intracellular calcium overload: relation with its antioxidant actions Melatonin promotes puromycin-induced apoptosis with activation of caspase-3 and 5 1 -adenosine monophosphate-activated kinase-alpha in human leukemia HL-60 cells Programmed cell death in the pathogenesis of rabbit hemorrhagic disease Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus Autophagy during common bacterial and viral infections of children Varicella-zoster virus infection induces autophagy in both cultured cells and human skin vesicles Autophagy proteins promote hepatitis C virus replication Structural and functional analysis of virus factories purified from Rabbit vesivirus-infected Vero cells Remodeling the endoplasmic reticulum by poliovirus infection and by individual viral proteins: an autophagy-like origin for virus-induced vesicles Melatonin modulates autophagy through a redox-mediated action in female Syrian hamster Harderian gland controlling cell types and gland activity Regression of herpes viral infection symptoms using melatonin and SB-73: comparison with Pineal melatonin: cell biology of its synthesis and of its physiological interactions Melatonin: a multitasking molecule A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease Melatonin as a therapeutic tool in ophthalmology: implications for glaucoma and uveitis Drug-mediated ototoxicity and tinnitus: alleviation with melatonin Matrix metalloproteinases in health and disease: regulation by melatonin The authors have no competing interest. keywords: antioxidant; cells; damage; disease; effects; expression; factor; human; infection; melatonin; mice; nitric; oxidative; oxide; production; role; treatment; virus cache: cord-310942-191m0e65.txt plain text: cord-310942-191m0e65.txt item: #126 of 153 id: cord-313227-6zwkfzab author: Scala, Stefania title: Fighting the Host Reaction to SARS-COv-2 in Critically Ill Patients: The Possible Contribution of Off-Label Drugs date: 2020-05-27 words: 3882 flesch: 26 summary: Med Hypotheses Pioglitazone, a peroxisome proliferator-activated receptor gamma ligand, suppresses bleomycin-induced acute lung injury and fibrosis CXCR4 knockdown prevents inflammatory cytokine expression in macrophages by suppressing activation of MAPK and NF-kappaB signaling pathways CXCR4 inhibitor attenuates ovalbumin-induced airway inflammation and hyperresponsiveness by inhibiting Th17 and Tc17 cell immune response Plerixafor enables safe, rapid, efficient mobilization of hematopoietic stem cells in sickle cell disease patients after exchange transfusion Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection COVID-19 infection in a patient with multiple sclerosis treated with fingolimod Benefitrisk profile of sphingosine-1-phosphate receptor modulators in relapsing and secondary progressive multiple sclerosis The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. CXCR4-mediated inflammatory responses is based on the efficient chemotaxis function of inflammatory cells, such as neutrophils, lymphocytes, and monocytes (66) . keywords: cells; coronavirus; covid-19; cytokines; immune; infection; lung; macrophages; patients; sars; tnf; virus cache: cord-313227-6zwkfzab.txt plain text: cord-313227-6zwkfzab.txt item: #127 of 153 id: cord-316904-g7dli0a8 author: Chang, Hernan R. title: Role of cytokines in AIDS wasting date: 1998-12-31 words: 8304 flesch: 31 summary: However, subsequent studies failed to show high-serum TNF levels in most AIDS patients, and no correlation appeared to exist between serum TNF levels and the magnitude of weight loss in AIDS patients. In AIDS patients with anorexia and weight loss, conversion of thyroxine to T3 is decreased (euthyroid sick syndrome) as well as the levels of insulin-like growth factor-I (IGF-I), whereas in stable HIV patients T3 levels are normal. keywords: aids; body; cytokines; effects; factor; hiv; il-1; infection; levels; muscle; patients; role; tnf; wasting; weight cache: cord-316904-g7dli0a8.txt plain text: cord-316904-g7dli0a8.txt item: #128 of 153 id: cord-317628-1inxq7t5 author: Cuccarese, Michael F. title: Functional immune mapping with deep-learning enabled phenomics applied to immunomodulatory and COVID-19 drug discovery date: 2020-08-14 words: 9597 flesch: 35 summary: However, the immune system is vastly complex and dependent on cell type and context; reliably intervening in such a highly interdependent process is a formidable drug discovery challenge. Taken together these findings suggest that SARS-CoV-2 entry protease inhibitor activity varies across cell type and species; however, remdesivir and GS-441524 show strong rescue of the viral phenoprint in all cell types tested. keywords: cells; compounds; covid-19; cytokine; data; disease; dose; fig; image; immune; infection; inhibitors; perturbation; phenoprint; response; sars; screening; stimuli; storm; tgf; tnf; type cache: cord-317628-1inxq7t5.txt plain text: cord-317628-1inxq7t5.txt item: #129 of 153 id: cord-319121-et957lfl author: Mifflin, Lauren title: Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target date: 2020-07-15 words: 12659 flesch: 20 summary: The pseudokinase MLKL and the kinase RIPK3 have distinct roles in autoimmune disease caused by loss of death-receptor-induced apoptosis RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis Cutting edge: RIPK1 kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo Cutting edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPINdeficient mice This paper demonstrates RIPK1 activation in human RA and psoriasis samples by pS166 immunochemistry, efficacy of a RIPK1 inhibitor in animal disease models of IBD, RA and skin inflammation, and effect of RIPK1 inhibitor for pancreatic cancer metastases RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome Cutting edge: RIPK1 kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation TAB2 and TAB3 activate the NF-κB pathway through binding to polyubiquitin chains Holding RIPK1 on the ubiquitin leash in TNFR1 signaling ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC Ubiquitin-mediated regulation of RIPK1 kinase activity independent of IKK and MK2 A20-a bipartite ubiquitin editing enzyme with immunoregulatory potential Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1 2020) (ref. 41), this paper reports the discovery of a dominant autoinflammatory human disease caused by non-cleavable RIPK1 Activity of caspase-8 determines plasticity between cell death pathways Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis RIPK1 can mediate apoptosis in addition to necroptosis during embryonic development NF-κB pathway in autoinflammatory diseases: dysregulation of protein modifications by ubiquitin defines a new category of autoinflammatory diseases Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease Haploinsufficiency of A20 impairs protein-protein interactome and leads into caspase-8-dependent enhancement of NLRP3 inflammasome activation Analysis of 17 autoimmune diseaseassociated variants in type 1 diabetes identifies 6q23/ TNFAIP3 as a susceptibility locus Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells Keratinocyte expression of A20/ TNFAIP3 controls skin inflammation associated with atopic dermatitis and psoriasis Regulation and function of IKK and IKK-related kinases Specific recognition of linear ubiquitin chains by NEMO is important for NF-κB activation Infliximab therapy for inflammatory colitis in an infant with NEMO deficiency NEMO/IKKγ-deficient mice model incontinentia pigmenti Female mice heterozygous for IKKγ/ NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling NEMO prevents RIP kinase 1-mediated epithelial cell death and chronic intestinal inflammation by NF-κ-dependent and -independent functions OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin The deubiquitinase OTULIN is an essential negative regulator of inflammation and autoimmunity Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease OTULIN limits cell death and inflammation by deubiquitinating LUBAC OTULIN deficiency in ORAS causes cell type-specific LUBAC degradation, dysregulated TNF signalling and cell death Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia Second case of HOIP deficiency expands clinical features and defines inflammatory transcriptome regulated by LUBAC Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency Cell death and inflammation -a vital but dangerous liaison A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice Linear ubiquitination prevents inflammation and regulates immune signalling RIP1 kinase activity is critical for skin inflammation but not for viral propagation Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease Epidemiology of inflammatory bowel disease in a German twin cohort: results of a nationwide study Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death A20 prevents inflammasomedependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain A20 controls intestinal homeostasis through cell-specific activities Crohn disease: a current perspective on genetics, autophagy and immunity Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3 Distinct kinase and scaffold functions of RIPK1 RIPK1 is a 76-kDa protein with an amino-terminal (N-terminal) kinase domain, a carboxy-terminal (C-terminal) death domain and an intermediate domain with a RHIM (receptor-interacting protein homotypic interacting motif) that can bind to other NF-κB (Nuclear factor κ light chain enhancer of activated B cells). keywords: a20; activation; activity; cell; complex; death; disease; domain; human; inflammation; inflammatory; inhibition; inhibitors; kinase; mice; mutations; necroptosis; nemo; patients; protein; receptor; ripk1; tnf cache: cord-319121-et957lfl.txt plain text: cord-319121-et957lfl.txt item: #130 of 153 id: cord-322250-7kjakuyw author: He, Jia title: Anemoside B4 protects against Klebsiella pneumoniae- and influenza virus FM1-induced pneumonia via the TLR4/Myd88 signaling pathway in mice date: 2020-07-02 words: 4924 flesch: 41 summary: The counts of neutrophil (NEU) and white blood cell (WBC), the level of myeloperoxidase (MPO), and the release of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 increased by KP or FM1 infection, which were reversed by anemoside B4. Next, we investigated the effect of anemoside B4 on pro-inflammatory cytokines in vivo. keywords: anemoside; anemoside b4; fm1; group; il-6; influenza; lung; mice; pneumonia; tlr4; tnf; virus cache: cord-322250-7kjakuyw.txt plain text: cord-322250-7kjakuyw.txt item: #131 of 153 id: cord-323553-bukm9m9q author: Song, Woo-Jin title: Canine adipose tissue-derived mesenchymal stem cells pre-treated with TNF-alpha enhance immunomodulatory effects in inflammatory bowel disease in mice date: 2019-08-31 words: 4255 flesch: 41 summary: Pharmacokinetics and clinical efficacy of cyclosporine treatment of dogs with steroid-refractory inflammatory bowel disease Exploring the role of soluble factors associated with immune regulatory properties of mesenchymal stem cells Intraperitoneally infused human mesenchymal stem cells form aggregates with mouse immune cells and attach to peritoneal organs TNF-α and IL-1β-activated human mesenchymal stromal cells increase airway epithelial wound healing in vitro via activation of the epidermal growth factor receptor Inflammatory bowel disease in the dog: differences and similarities with humans Immunomodulatory effects of soluble factors secreted by feline adipose tissuederived mesenchymal stem cells Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses Canine inflammatory bowel disease: retrospective analysis of diagnosis and outcome in 80 cases Protein-losing enteropathies in dogs Pretreatment with IL-1β enhances the efficacy of MSC transplantation in DSS-induced colitis Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis Tumor necrosis factor-α-activated human adipose tissue-derived mesenchymal stem cells accelerate cutaneous wound healing through paracrine mechanisms Anti-inflammatory effects of mesenchymal stem cells: novel concept for future therapies Soluble factors-mediated immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells Human Umbilical Cord Blood Mesenchymal Stem Cells Reduce Colitis in Mice by Activating NOD2 Signaling to COX2 Human umbilical cord blood mesenchymal stem cell-derived PGE2 and TGF-β1 alleviate atopic dermatitis by reducing mast cell degranulation Canine adipose tissue-derived mesenchymal stem cells ameliorate severe acute pancreatitis by regulating T cells in rats Clinical trial of human umbilical cord blood-derived stem cells for the treatment of moderate-to-severe atopic dermatitis: phase I/IIa studies Mesenchymal stem cells and their therapeutic applications in inflammatory bowel disease The Commensal Bacterium Faecalibacterium prausnitzii Is Protective in DNBS-induced Chronic Moderate and Severe Colitis Models Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages Angiogenic and anti-inflammatory properties of mesenchymal stem cells from cord blood: soluble factors and extracellular vesicles for cell regeneration DNBS/TNBS Colitis Models: Mesenchymal stem cells (MSCs), which release immunomodulatory factors such as tumor necrosis factor-α (TNF-α)-induced gene/protein 6 (TSG-6) and prostaglandin E2 (PGE2), have been suggested as an alternative therapeutic option for IBD treatment in veterinary medicine. keywords: cat; cells; colitis; mice; mscs; stem; tnf cache: cord-323553-bukm9m9q.txt plain text: cord-323553-bukm9m9q.txt item: #132 of 153 id: cord-324949-sqy03dks author: Poe, Francis L. title: N-Acetylcysteine: a potential therapeutic agent for SARS-CoV-2 date: 2020-05-30 words: 3488 flesch: 44 summary: In patients with HIV, oral NAC increased both whole blood glutathione levels and lymphocyte count (CD4+ and CD8+) In a randomized clinical trial, oral NAC demonstrated decreases in TNF-ɑ and no adverse reactions at 1200 mg daily, however there were no changes in computed tomography scores between those treated with NAC and the control group keywords: cell; coronavirus; cov-2; covid-19; glutathione; nac; sars; tnf cache: cord-324949-sqy03dks.txt plain text: cord-324949-sqy03dks.txt item: #133 of 153 id: cord-330549-ppuqvafd author: Christophi, George P. title: Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype date: 2009-04-27 words: 9901 flesch: 32 summary: Moreover, IP-10 was induced to significantly higher levels in MS macrophages compared to normal subject macrophages ( Figure 6C) . Moreover, when macrophages were exposed to M2-inducing cytokine IL-4, MS macrophages expressed more arginase I than normal subject macrophages. keywords: activation; cells; expression; figure; genes; levels; macrophages; ms patients; patients; protein; sclerosis; shp-1; stat6; subjects; tnf cache: cord-330549-ppuqvafd.txt plain text: cord-330549-ppuqvafd.txt item: #134 of 153 id: cord-332071-bqvn3ceq author: Lee, Jeong Seok title: Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19 date: 2020-07-10 words: 7122 flesch: 46 summary: Based on the distribution of UMI counts, the cluster 'Uncategorized 1' was featured by relatively high UMIs per cell compared to other clusters and presence of higher expression of multiple cell type marker genes. These results indicate that, in COVID-19, peripheral blood immune cells may be influenced by common inflammatory mediators regardless of cell type. keywords: analysis; cell; cluster; covid-19; disease; fig; genes; ifn; influenza; monocytes; patients; response; tnf; type cache: cord-332071-bqvn3ceq.txt plain text: cord-332071-bqvn3ceq.txt item: #135 of 153 id: cord-333650-4towah1t author: Malmo, Jostein title: Cytokine Profiles in Human Metapneumovirus Infected Children: Identification of Genes Involved in the Antiviral Response and Pathogenesis date: 2016-05-12 words: 4668 flesch: 43 summary: Further, the expression of IL-6 ( Fig 4C) was not increased at mRNA level in any of the groups with hMPV infected children. The lack of IFN-γ detection in NPAs from hMPV infected children has also recently been reported elsewhere [31] . keywords: children; expression; hmpv; ifn; infection; mrna; patients; severity cache: cord-333650-4towah1t.txt plain text: cord-333650-4towah1t.txt item: #136 of 153 id: cord-335185-3qi29i6n author: Hendry, Bruce M. title: Hypothesis: Pentoxifylline is a potential cytokine modulator therapeutic in COVID‐19 patients date: 2020-07-26 words: 2474 flesch: 32 summary: a model of old drugs for new horizons Protective effects of pentoxifylline in pulmonary inflammation are adenosine receptor A2A dependent Inhibition of cytokine release from alveolar macrophages in pulmonary sarcoidosis by pentoxifylline: comparison with dexamethasone Pentoxifylline attenuates nitrogen mustard-induced acute lung injury, oxidative stress and inflammation Pentoxifylline suppresses renal tumour necrosis factor-alpha and ameliorates experimental crescentic glomerulonephritis in rats Pentoxifylline in prevention of radiation-induced lung toxicity in patients with breast and lung cancer: a double-blind randomized trial The inhibition of pro-inflammatory cytokines with pentoxifylline in the cardiopulmunary bypass lung Prednisolone or pentoxifylline for alcoholic hepatitis Pentoxifylline inhibits TNF-alpha production from human alveolar macrophages Bird Flu), inflammation and anti-inflammatory/analgesic drugs Necrosis factor-α signaling in macrophages Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans Influenza leaves a trail to pulmonary oedema Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in COVID-19 Repositioning of pentoxifylline as an immunomodulator and regulator of the renin-angiotensin system in the treatment of COVID-19 Inhibitors of the reninangiotensin-aldosterone system and Covid-19 Immunomodulatory properties of pentoxifylline are mediated via adenosine-dependent pathways Focusing on adenosine receptors as a potential targeted therapy in human diseases SARS-CoV-2 infection and overactivation of Nlrp3 inflammasome as a trigger of cytokine storm and risk factor for damage of hematopoietic stem cells Hypercoagulation and antithrombotic treatment in coronavirus 2019: a new challenge 14 One of the largest scale clinical trials of pentoxifylline anti-inflammatory effects within the last decade, was the STOPAH trial. keywords: alpha; covid-19; cytokine; lung; patients; pentoxifylline; tnf cache: cord-335185-3qi29i6n.txt plain text: cord-335185-3qi29i6n.txt item: #137 of 153 id: cord-336432-tu00gffr author: Wang, Zhiyu title: Small molecule therapeutics for COVID-19: repurposing of inhaled furosemide date: 2020-07-07 words: 6618 flesch: 40 summary: We investigated if furosemide inhibits the production of pro-inflammatory cytokines (M1) or promotes the secretion of anti-inflammatory cytokines (M2) using various macrophage cell lines including RAW264.7, THP-1 and SIM-A9. In this study, a library of small molecules endogenous to the human body was assembled, subjected to in silico molecular docking simulations and a focused in vitro screen to identify anti-pro-inflammatory activity via interleukin inhibition. keywords: acid; cells; covid-19; cytokines; docking; furosemide; haa; il-6; ligand; lps; pro; protein; tnf cache: cord-336432-tu00gffr.txt plain text: cord-336432-tu00gffr.txt item: #138 of 153 id: cord-336510-qzm9wgde author: Ellermann-Eriksen, Svend title: Macrophages and cytokines in the early defence against herpes simplex virus date: 2005-08-03 words: 20078 flesch: 41 summary: During HSV infection macrophages are activated and possess an increased antiviral potential Occurrence in an adult with pemphigus vulgaris Herpes simplex virus infections Acute hepatitis due to Herpes simplex virus in an adult Disseminated herpes simplex in pregnancy: two cases and a review Herpesvirus hominis type 2 meningoencephalitis following renal transplantation The acquisition of herpes simplex virus during pregnancy Neonatal herpes simplex virus infection in relation to asymptomatic maternal infection at the time of labor Herpes simplex virus infections of women and their offspring: implications for a developed society Neonatal herpes simplex virus infections: is there a role for immunoglobulin in disease prevention and therapy? Type-specific antibody to Herpes Simplex Virus type 2(HSV-2) glycoprotein G in pregnant women, infants exposed to maternal HSV-2 infection at delivery, and infants with Neonatal Herpes Low risk of herpes simplex virus infections in neonates exposed to the virus at the time of vaginal delivery to mothers with recurrent genital herpes simplex virus infections Neonatal herpes simplex infection Safety and efficacy of highdose intravenous acyclovir in the management of neonatal herpes simplex virus infections Natural history of neonatal herpes simplex virus infections in the acyclovir era Advances in the treatment of neonatal herpes simplex infections HSV-2 replication sites, monocyte and lymphocytic cell infection and virion phagocytosis by neutrophils, in vesicular lesions on penile skin. keywords: activation; activity; antiviral; cells; effect; factor; herpes; hsv; hsv infection; ifn; il-12; induction; infection; interferon; macrophages; mechanisms; mice; production; replication; response; simplex; system; tnf; type; virus; virus type cache: cord-336510-qzm9wgde.txt plain text: cord-336510-qzm9wgde.txt item: #139 of 153 id: cord-337414-8ndkjs1i author: Burgmaier, Gruscha title: Association of Increased Bcl‐2 Expression with Rescue from Tumor Necrosis Factor‐α‐Induced Cell Death in the Oligodendrocyte Cell Line OLN‐93 date: 2008-07-29 words: 3879 flesch: 42 summary: Flupirtine significantly reduced the spontaneous cell death rate already at low concentrations of 1 M. TNF-␣-induced apoptosis was also prevented by flupirtine; however, higher concentrations of flupirtine were required to rescue OLN cells from cell death (Figs. 1b and c and 5). It is, however, not yet clear whether oligodendrocytes die via apoptosis or necrosis, which are different mechanisms of cell death (Selmaj et al., 1991; Lucchinetti et al., 1996) . keywords: apoptosis; cells; death; flupirtine; oligodendrocytes; oln; protein; tnf- cache: cord-337414-8ndkjs1i.txt plain text: cord-337414-8ndkjs1i.txt item: #140 of 153 id: cord-339272-trd6rkxw author: Chen, Na title: Prime-O-glucosylcimifugin attenuates lipopolysaccharide-induced acute lung injury in mice date: 2013-04-24 words: 4323 flesch: 40 summary: Seven hours after LPS administration, the BALF was collected to evaluate the total cell counts and the number of inflammatory cells in BALF, such as macrophages and neutrophils. In the LPS group, the lungs were significantly damaged with inflammatory cell infiltration, alveolar wall thickening and interstitial edema. keywords: acute; cells; glucosylcimifugin; il-6; injury; lps; lung; mice; prime; tnf cache: cord-339272-trd6rkxw.txt plain text: cord-339272-trd6rkxw.txt item: #141 of 153 id: cord-340741-bhxm4zua author: Nayak, Tapas Kumar title: P38 and JNK Mitogen-Activated Protein Kinases Interact With Chikungunya Virus Non-structural Protein-2 and Regulate TNF Induction During Viral Infection in Macrophages date: 2019-04-12 words: 8048 flesch: 38 summary: A strong polar interaction was predicted between Thr-180 (within the phosphorylation lip) of p38 and Gln-273 of nsP2, whereas, no such polar interaction was predicted for the phosphorylation lip of JNK which indicates the differential roles of p-p38 and p-JNK during CHIKV infection in the host macrophages. Hence, this information might shed light in rationale-based drug designing strategies toward a possible control measure of CHIKV infection in future. keywords: activation; cells; chikungunya; chikv; host; infected; infection; jnk; macrophages; nsp2; p38; phosphorylation; protein; tnf; virus cache: cord-340741-bhxm4zua.txt plain text: cord-340741-bhxm4zua.txt item: #142 of 153 id: cord-341667-ayl71jpc author: Van Reeth, Kristien title: Bronchoalveolar Interferon-α, Tumor Necrosis Factor-α, Interleukin-1, and Inflammation during Acute Influenza in Pigs: A Possible Model for Humans? date: 1998-04-17 words: 1971 flesch: 44 summary: Levels of the three cytokines were significantly higher 18 -24 h after inoculation than at 48 -72 h after inoculation (P õ Clinical responses, influenza virus titers, BAL cell numbers, percentage of neutrophils, and cytokine titers of individual pigs .016 for all three cytokines). Evidence for a role of TNF-a and IL-1 in influenza virus right lung was lavaged with 60 mL of PBS. keywords: influenza; pigs; tnf; virus cache: cord-341667-ayl71jpc.txt plain text: cord-341667-ayl71jpc.txt item: #143 of 153 id: cord-344204-qq2vqzc2 author: Hariharan, Apurva title: The Role and Therapeutic Potential of NF-kappa-B Pathway in Severe COVID-19 Patients date: 2020-11-07 words: 5660 flesch: 33 summary: The data from epidemiological studies revealed sex-specific differences in the incidence and mortality in COVID-19 patients, where the mortality rate of men is more than female. The possible reason for this cytokine storm in COVID-19 patients might be the elevated level of anti-viral inflammatory cytokines (IL-10, IL-6, IL-2, IFN-γ and TNF-α) which were attenuated and diversified in SARS and MERS infections, respectively . keywords: activation; coronavirus; covid-19; cytokine; et al; pathway; patients; sars; storm; tnf cache: cord-344204-qq2vqzc2.txt plain text: cord-344204-qq2vqzc2.txt item: #144 of 153 id: cord-346669-7n75m669 author: Wang, Shixin title: Roles of TNF-α gene polymorphisms in the occurrence and progress of SARS-Cov infection: A case-control study date: 2008-02-29 words: 3816 flesch: 45 summary: Cured SARS patients with interstitial lung fibrosis were diagnosed by respiratory experts according to CT results following the standard proposal for therapy and diagnosis of SARS patients issued by Chinese Ministry of Health in 2004 After discharging from hospital, interstitial lung fibrosis was observed in SARS patients. keywords: fibrosis; gene; head; lung; necrosis; patients; polymorphisms; sars; tnf cache: cord-346669-7n75m669.txt plain text: cord-346669-7n75m669.txt item: #145 of 153 id: cord-347298-7kqrl3rv author: Hedger, M.P. title: Immunology of the Testis and Male Reproductive Tract date: 2010-07-12 words: 21190 flesch: 40 summary: Tung et al. 1981) . In many seasonally breeding species, annual regression of the bloodtestis barrier occurs without inducing overt inflammation or autoimmunity (Pelletier 1986; Tung et al. 1981) . keywords: activation; activin; activity; cells; cytokines; epithelium; et al; expression; function; germ; ifn; il1; immune; immunity; inflammation; leydig; macrophages; male; molecules; production; proteins; rat; receptor; responses; role; sertoli; sertoli cells; studies; system; t cells; testicular; testis; tnf; tract; type cache: cord-347298-7kqrl3rv.txt plain text: cord-347298-7kqrl3rv.txt item: #146 of 153 id: cord-348391-xytmq2f2 author: Wyganowska-Swiatkowska, Marzena title: Influence of Herbal Medicines on HMGB1 Release, SARS-CoV-2 Viral Attachment, Acute Respiratory Failure, and Sepsis. A Literature Review date: 2020-06-30 words: 8109 flesch: 34 summary: All of the identified herbal extracts and flavonoids exert suppression of HMGB1 activity. All of the identified herbal extracts and flavonoids exert suppression of HMGB1 activity. keywords: activity; cell; effect; expression; extract; hmgb1; human; infection; inhibition; lung; mice; protein; release; sars; sepsis; tnf; viral; virus cache: cord-348391-xytmq2f2.txt plain text: cord-348391-xytmq2f2.txt item: #147 of 153 id: cord-348855-lnltoj1n author: Iannaccone, Giulia title: Weathering the Cytokine Storm in COVID-19: Therapeutic Implications date: 2020-06-29 words: 4681 flesch: 28 summary: For these reasons, the WHO does not recommend routine administration of CS in COVID-19 patients outside of clinical trials; their adjunctive use may be indicated on an individual basis or unless indicated for other conditions, such as chronic obstructive pulmonary disease, asthma, and septic shock [23] . Moreover, in 2 small retrospective studies of COVID-19 patients in China suffering from severe lung injury it was observed that the use of this agent could provide significant clinical improvement without important side effects [38, 39] . keywords: coronavirus; covid-19; cytokine; disease; infection; patients; response; sars; syndrome; therapy; treatment; use cache: cord-348855-lnltoj1n.txt plain text: cord-348855-lnltoj1n.txt item: #148 of 153 id: cord-351310-6p42b144 author: Bohr, Adam title: Treatment of acute lung inflammation by pulmonary delivery of anti-TNF-α siRNA with PAMAM dendrimers in a murine model date: 2020-08-13 words: 4349 flesch: 45 summary: Mechanistic profiling of the release kinetics of siRNA from lipidoidpolymer hybrid nanoparticles in vitro and in vivo after pulmonary administration Overcoming the challenges of siRNA delivery: nanoparticle strategies Nanoscale particles for lung delivery of siRNA Knocking down barriers: advances in siRNA delivery Rational design of cationic lipids for siRNA delivery Current progress in gene delivery technology based on chemical methods and nano-carriers Non-viral methods for siRNA delivery Dendrimers and hyperbranched polymers Nanomaterials based on phosphorus dendrimers Anti-Inflammatory Effect of Anti-TNF-α SiRNA Cationic Phosphorus Dendrimer Nanocomplexes Administered Intranasally in a Murine Acute Lung Injury Model Dendrimers for siRNA delivery Delivering siRNA with Dendrimers: In Vivo Applications Poly (amidoamine)(PAMAM) dendrimer mediated delivery of drug and pDNA/siRNA for cancer therapy Chitosan/siRNA Nanoparticle-mediated TNF-α Knockdown in Peritoneal Macrophages for Antiinflammatory Treatment in a Murine Arthritis Model Comparison of Polymeric siRNA Nanocarriers in a Murine LPS-Activated Macrophage Cell Line: Gene Silencing, Toxicity and Off-Target Gene Expression IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger Local stimulation of alpha7 cholinergic receptors inhibits LPS-induced TNF-alpha release in the mouse lung Van Der Poll, the LPS-Induced Lung Inflammation In Vivo 1 Elucidating the molecular mechanism of PAMAM-siRNA dendriplex self-assembly: Effect of dendrimer charge density Polyamidoamine dendrimers with a modified pentaerythritol core having high efficiency and low cytotoxicity as gene carriers Overcoming the innate immune response to small interfering RNA, Hum Chemical modification of siRNAs to improve serum stability without loss of efficacy Effect of the Route of Administration and PEGylation of Poly(amidoamine) Dendrimers on Their Systemic and Lung Cellular Biodistribution Polyamidoamine dendrimers can improve the pulmonary absorption of insulin and calcitonin in rats PAMAM dendrimers as nano carriers to investigate inflammatory responses induced by pulmonary exposure of PCB metabolites in Sprague-Dawley rats Nasal lipopolysaccharide challenge and cytokine measurement reflects innate mucosal immune responsiveness A prominent role for airway epithelial NF-κB activation in lipopolysaccharide-induced airway inflammation Acute Lung Injury: Prevention May Be the Best Medicine Living with chronic obstructive pulmonary disease: a survey of patients' knowledge and attitudes In vivo tumor targeting via nanoparticle-mediated therapeutic siRNA coupled to inflammatory response in lung cancer mouse models In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight Lipid envelope-type nanoparticle incorporating a multifunctional peptide for systemic siRNA delivery to the pulmonary endothelium Anti-TNFα therapy in inflammatory lung diseases Elucidating the role of surface chemistry on cationic phosphorus dendrimer-siRNA complexation The authors would like to thank the Danish Council for Independent Research The PAMAM dendrimer-siRNA complexes (dendriplexes) displayed strong siRNA condensation and high cellular uptake in macrophages compared with non-complexed siRNA. keywords: cells; delivery; dendrimers; dendriplexes; inflammation; lps; lung; pamam; sirna; studies; tnf cache: cord-351310-6p42b144.txt plain text: cord-351310-6p42b144.txt item: #149 of 153 id: cord-351387-i0zamkpd author: Witte, Katrin title: The Pelargonium sidoides Extract EPs 7630 Drives the Innate Immune Defense by Activating Selected MAP Kinase Pathways in Human Monocytes date: 2015-09-25 words: 4380 flesch: 42 summary: However, the effects of Pelargonium sidoides and a special extract prepared from its roots (EPs 7630) on human immune cells are not fully understood. Therefore, the focus of our current study was to unravel the possible influence of EPs 7630 on human immune cells. keywords: cells; cytokine; eps; human; pbmcs; pelargonium; production; sidoides; tnf cache: cord-351387-i0zamkpd.txt plain text: cord-351387-i0zamkpd.txt item: #150 of 153 id: cord-353887-f4yd7guj author: Tang, Yujun title: Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies date: 2020-07-10 words: 8554 flesch: 36 summary: medRxiv Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis Tocilizumab, an anti-IL6 receptor antibody, to treat Covid-19-related respiratory failure: a case report First case of COVID-19 in a patient with multiple myeloma successfully treated with tocilizumab A case of novel coronavirus disease 19 in a chronic hemodialysis patient presenting with gastroenteritis and developing severe pulmonary disease Dramatic improvement after Tocilizumab of a severe COVID-19 in a child with sickle cell disease and acute chest syndrome Tocilizumab treatment in COVID-19: a single center experience Effective treatment of severe COVID-19 patients with tocilizumab Pilot prospective open, single-arm multicentre study on off-label use of tocilizumab in severe patients with COVID-19 Use of tocilizumab for COVID-19 infection-induced cytokine release syndrome: a cautionary case report EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update Safety of synthetic and biological DMARDs: a systematic literature review informing the 2019 update of the EULAR recommendations for the management of rheumatoid arthritis Negative regulation of nuclear factor-kappaB activation and function by glucocorticoids Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: evidence for post-transcriptional regulation Kelley's Textbook of Rheumatology E-Book The effect of corticosteroid treatment on patients with coronavirus infection: a systematic review and meta-analysis Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province Corticosteroid treatment of patients with coronavirus disease 2019 ( Besides, corticosteroids, programmed cell death protein (PD)-1/PD-L1 checkpoint inhibition, cytokine-adsorption devices, intravenous immunoglobulin, and antimalarial agents could be potentially useful and reliable approaches to counteract cytokine storm in COVID-19 patients. keywords: activation; artemisinin; artesunate; cells; coronavirus; covid-19; cytokines; disease; il-6; infection; inflammatory; levels; macrophages; patients; sars; storm; study; syndrome; treatment cache: cord-353887-f4yd7guj.txt plain text: cord-353887-f4yd7guj.txt item: #151 of 153 id: cord-354492-6r6qs4pp author: Messina, Giovanni title: Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work date: 2020-04-28 words: 6885 flesch: 32 summary: An interesting study reported that systemic adiponectin concentrations in humans fall during the acute phase of lung infection: particularly, during the early phase, the pro-inflammatory state is generated by the high systemic TNF-α and IL-6 concentrations, with the subsequent inhibition of adiponectin production. As previously described, other dietary constituents can be used to improve the patients' outcomes during lung infection, regulating the inflammatory response. keywords: acute; adiponectin; covid-19; il-6; infection; inflammation; levels; lung; patients; response; role; tnf; ω-3 cache: cord-354492-6r6qs4pp.txt plain text: cord-354492-6r6qs4pp.txt item: #152 of 153 id: cord-354765-abayh871 author: Graham, R. S. title: Calming the Cytokine Storm - Splenic Ultrasound for Treating Inflammatory Disorders and Potentially COVID-19 date: 2020-07-17 words: 8854 flesch: 35 summary: In healthy individuals, a single three-minute administration of splenic ultrasound stimulation significantly inhibits whole blood TNF production upon ex vivo exposure to endotoxin compared to sham controls. Further supporting the human results, we also demonstrated that splenic ultrasound stimulation in a rodent model achieves a reduction across a number of proinflammatory cytokines beyond TNF, including IL-6, IFNγ, IL-1β, IL-1α, and IL-12 in splenic lysates (Fig. S1 ), which is consistent with previous reports using implanted vagus nerve stimulators (18, 44) . keywords: blood; cell; covid-19; cytokine; fig; genes; lps; monocytes; pathway; patients; response; spleen; stimulation; study; subjects; tnf; treatment; ultrasound cache: cord-354765-abayh871.txt plain text: cord-354765-abayh871.txt item: #153 of 153 id: cord-355847-1ru15s5a author: Convertino, Irma title: Exploring pharmacological approaches for managing cytokine storm associated with pneumonia and acute respiratory distress syndrome in COVID-19 patients date: 2020-06-11 words: 2944 flesch: 35 summary: Several drugs, endowed with modulating activity on cytokine pathways, including anti-IL-6, anti-TNF, and Janus kinase (JAK) inhibitors, currently approved for the treatment of immune-mediated inflammatory diseases, have been suggested or could be yet taken into account for experimental use in COVID-19 patients with ARDS and/or pneumonia ( Fig. 1 ). Moreover, a multicenter randomized clinical trial in COVID-19 patients with ARDS, treated with tocilizumab at a dose of 4~8 mg/kg once, and an additional same dose when fever persists within 24 h after the first administration, has been approved in China [16] . keywords: anti; ards; covid-19; il-6; iqr; patients; tnf cache: cord-355847-1ru15s5a.txt plain text: cord-355847-1ru15s5a.txt