item: #1 of 171 id: cord-000083-3p81yr4n author: None title: Poster Exhibition date: 2009-01-31 words: 113010 flesch: 51 summary: From this group of HBV patients 35 (98%) have had elevated urinal Dol excreation (45,8±5,2 g/ml vs . 3% and 47.4 respectively in HCC patients, 60.3% and 39.7 in LC patients, 55% and 40 in CHB patients, 55% and 40 in ACLF patients. keywords: activity; acute; adefovir; adv; afp; age; aim; aims; alt; alt levels; analysis; anti; assay; associated; b virus; background; baseline; blood; cancer; carcinoma; cases; cells; chb patients; china; chronic hcv; chronic hepatitis; clinical; combination; conclusion; control; control group; copies; correlation; data; days; development; diagnosis; difference; dna levels; dose; drug; effect; efficacy; end; etv; expression; factors; fibrosis; follow; gene; genotype; group; group b; hbeag; hbv dna; hbv genotype; hbv infection; hcc cell; hcc patients; hcv; hepatic; hepatitis b; hepatitis patients; hepatocellular; hospital; ifn; increase; infected; lamivudine; levels; liver; liver biopsy; liver cirrhosis; liver disease; load; low; male; markers; mean; median; medical; methods; model; months; mrna; mutation; nafld; negative; non; p<0.05; patients; patients chronic; pcr; positive; prevalence; protein; rate; ratio; rats; recurrence; related; resistance; respectively; response; results; rfa; risk; rna; role; samples; score; seroconversion; serum alt; serum hbv; significant; specific; study; study group; subjects; survival; svr; therapy; time; total; treatment; treatment group; tumor; university; virus; weeks; years cache: cord-000083-3p81yr4n.txt plain text: cord-000083-3p81yr4n.txt item: #2 of 171 id: cord-000843-e1bn79ui author: None title: ECR 2011 Book of Abstracts - A - Postgraduate Educational Programme date: 2011-03-01 words: 91300 flesch: 40 summary: Both conditions are easily discernible with CT imaging. CT perfusion imaging is a quantitative technique that employs rapid sequences of CT images after bolus administration of intravenous contrast material to measure a range of physiological processes related to the microvasculature of tissues. keywords: acute; approach; assessment; benign; bone; brain; breast imaging; cancer; cardiac; cases; cause; changes; chest; children; complications; conditions; contrast; ct imaging; data; detection; development; diagnosis; differential; diffusion; disease; dose; evaluation; examination; field; findings; follow; functional; images; imaging; imaging features; imaging findings; imaging methods; imaging modality; imaging protocols; imaging techniques; information; knowledge; learning; lecture; lesions; liver; lung; management; mass; medical; modalities; mr imaging; mri; need; new; non; objectives; patients; pelvic; perfusion; perfusion imaging; pet; post; potential; practice; presentation; primary; procedures; pulmonary; quality; radiation; radiological; radiologist; radiology; resolution; resonance imaging; response; results; review; risk; role; screening; sensitivity; sequences; signal; staging; studies; surgery; system; therapy; time; tissue; treatment; tumour; ultrasound; use; vascular; years cache: cord-000843-e1bn79ui.txt plain text: cord-000843-e1bn79ui.txt item: #3 of 171 id: cord-001221-due9tloa author: None title: ECR 2014, Part A date: 2014-02-27 words: 107894 flesch: 38 summary: On CT imaging, thermal ablation areas are well circumscribed and oval shaped. MR imaging allows earlier detection of residual liver tumour than CT imaging. keywords: ablation; acute; analysis; approach; assessment; benign; biopsy; body; bone; brain; brain imaging; breast imaging; cancer; cardiac; care; cases; changes; children; complex; complications; conditions; contrast; coronary; criteria; ct imaging; current; data; detection; development; diagnosis; differential; diffusion; disease; dose; e.g.; enhancement; evaluation; evidence; examination; fat; features; follow; functional; help; high; image; imaging; imaging biomarkers; imaging criteria; imaging features; imaging findings; imaging methods; imaging modalities; imaging techniques; importance; inflammatory; information; interventional; key; knowledge; learning; lecture; lesions; liver; lung; malignant; management; modality; mr imaging; mri; need; new; non; number; objectives; patients; perfusion imaging; pet; pitfalls; post; potential; practice; presentation; procedures; protocols; pulmonary; quality; radiation; radiologists; radiology; research; resonance imaging; response; results; risk; role; session; size; specific; staging; standard; stroke; studies; study; surgery; systems; therapy; time; tissue; treatment; tumour; tumour imaging; ultrasound; use; value; vascular; years cache: cord-001221-due9tloa.txt plain text: cord-001221-due9tloa.txt item: #4 of 171 id: cord-002514-pp06m5xk author: Venkatesan, Sudhir title: Impact of Outpatient Neuraminidase Inhibitor Treatment in Patients Infected With Influenza A(H1N1)pdm09 at High Risk of Hospitalization: An Individual Participant Data Metaanalysis date: 2017-05-15 words: 4020 flesch: 36 summary: This was confirmed in recent IPD analysis of seasonal influenza patients that reported a risk reduction of 63% in treated patients (intention-to-treat infected population) These data suggest that community patients with severe influenza should receive NAI treatment. to 2009 also suggests that NAIs given to high-risk community patients with influenza may reduce subsequent hospitalization keywords: community; data; hospitalization; influenza; nai; patients; study; treatment cache: cord-002514-pp06m5xk.txt plain text: cord-002514-pp06m5xk.txt item: #5 of 171 id: cord-003372-cpl7zf7f author: Provoost, Judith title: A retrospective study of factors associated with treatment decision for nontuberculous mycobacterial lung disease in adults without altered systemic immunity date: 2018-12-14 words: 3389 flesch: 34 summary: In the absence of systemic immunodeficiency, decision of NTM lung disease treatment must relies on a careful risk/benefit assessment, given the requirement of long-term administration of multidrug therapies supported by limited evidence. This retrospective, single center study (2013–2016, 45 months) addressed the criteria supporting treatment decision among adults with NTM lung disease without systemic immunodeficiency at our institution, with the assigned goal to harmonize the practice. keywords: aspergillus; diagnosis; disease; lung; ntm; patients; study; treatment cache: cord-003372-cpl7zf7f.txt plain text: cord-003372-cpl7zf7f.txt item: #6 of 171 id: cord-004073-k6ad4qgu author: Kabir, K. M. Ariful title: Modelling and analysing the coexistence of dual dilemmas in the proactive vaccination game and retroactive treatment game in epidemic viral dynamics date: 2019-12-04 words: 5902 flesch: 38 summary: R. Soc Information cascades in complex networks Incorporating latent constraints to enhance inference of network structure Statistical physics of vaccination Vaccination and the theory of games Can influenza epidemics be prevented by voluntary vaccination? Three-strategy and four-strategy model of vaccination game introducing an intermediate protecting measure To vaccinate or not to vaccinate: a comprehensive study of vaccination-subsidizing policies with multi-agent simulations and mean-field modeling Influence of breaking the symmetry between disease transmission and information propagation networks on stepwise decisions concerning vaccination Investigation of epidemic spreading process on multiplex networks by incorporating fatal properties Suppression of epidemic spreading process on multiplex networks via active immunization Discerning influential spreaders in complex networks by accounting the spreading heterogeneity of the nodes Coevolution of vaccination opinions and awareness affecting the spread of epidemics Virus propagation and patch distribution in multiplex networks: modeling, analysis, and optimal allocation Community detection in temporal networks via a spreading process Coupled disease-behavior dynamics on complex networks: a review Effects of stubborn decision-makers on vaccination and disease propagation in social network Effect of noise-perturbing intermediate defense measures in voluntary vaccination games Realistic decision-making processes in a vaccination game Effect of intermediate defense measures in voluntary vaccination games Which is more effective for suppressing an infectious disease: imperfect vaccination or defense against contagion? Dynamical behaviors for vaccination can suppress infectious disease-a game theoretical approach Oseltamivir-resistant influenza A viruses circulating in Japan Dilemma game structure observed in traffic flow at a 2-to-1 lane junction Dilemma game structure hidden in traffic flow at a bottleneck due to a 2 into 1 lane junction /journal/rspa Proc. Also, our model gives a clear procedure to quantify the social dilemmas, respectively, entailed by 'vaccination game' and 'treatment game'. keywords: dilemma; epidemic; game; individuals; model; social; time; treatment; vaccination cache: cord-004073-k6ad4qgu.txt plain text: cord-004073-k6ad4qgu.txt item: #7 of 171 id: cord-005105-twsy61oq author: None title: SIU 2015 Abstracts date: 2015-09-21 words: 124278 flesch: 51 summary: Th e patients were discharged from hospital aft er a median of 4.5 days (range 3 to 7). Th e patients were classifi ed into Group 1 (n=67, 60.3%) and into Group 2 (n=44, 39.7%) based on the presence of BPH. keywords: aft; age; analysis; approach; average; biopsy; bladder; bladder cancer; blood; cancer; cancer patients; carcinoma; cases; catheter; cells; clinical; complications; conclusion; control; data; day; days; defi; diagnosis; diff; disease; dysfunction; e aim; e bladder; e diff; e fi; e incidence; e mean; e median; e patient; e results; e study; e use; ects; eff; effi; ere; erectile; erence; experience; expression; factors; female; follow; function; grade; group; group patients; hospital; identifi; improvement; index; initial; injury; introduction; kidney; laparoscopic; left; level; male; management; medical; months; nephrectomy; non; number; objective; operative; outcomes; overall; pain; patients; pca; pelvic; period; positive; post; postoperative; preoperative; primary; procedure; prostate; prostate cancer; prostatectomy; prostatic; psa; radical; range; rate; recurrence; renal; results; risk; rst; score; signifi; single; size; specifi; stage; standard; stent; stone; stricture; studies; study; surgery; surgical; survival; symptoms; technique; term; th e; therapy; time; total; tract; treated; treatment; tumor; urethral; urinary; urine; voiding; volume; weeks; years cache: cord-005105-twsy61oq.txt plain text: cord-005105-twsy61oq.txt item: #8 of 171 id: cord-005814-ak5pq312 author: None title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 words: 179325 flesch: 51 summary: Leukemia inhibitory factor (LIF), a growth factor recently recognised as a polyfunctional cytokine integrated in cytokine networks was measured in unconcentrated BALF of patients from different patient groups. It is difficult to generalize on intensive care units as different patient groups are in different ICUs aud there are great changes from one hospital to another and from one country to another. keywords: activity; acute; administration; admission; adult patients; age; aim; airway; analysis; apache; application; ards patients; arf; arterial; artery; assess; average; baseline; blood; blood flow; blood pressure; blood volume; breathing; cardiac; care patients; care unit; cases; catheter; cerebral; changes; chest; children; clinical; compliance; complications; concentration; conclusions; conditions; constant; control group; control patients; copd patients; correlation; course; cpb; criteria; critical; cvp; daily; damage; data; days; death; death patients; decrease; diagnosis; difference; disease; dose; drugs; duration; dysfunction; effect; emergency; end; evaluation; exchange; factors; failure; failure patients; findings; flow; fluid; following; frequency; function; gas; gastric; general; good; group; group b; group ii; group patients; h20; head; heart; hemodynamic; hepatic; hospital; hours; hypertension; icp; icu patients; iii; ill; illness; improvement; incidence; increase; index; infection; influence; infusion; injury; intensive; introduction; intubation; lactate; left; levels; life; liver; lung; male; management; map; mean; measurements; median; medical; methods; min; minutes; mmhg; model; monitoring; mortality; mortality rate; muscle; myocardial; need; negative; new; non; normal; number; objectives; onset; operation; order; organ; outcome; output; oxygen; oxygenation; p =; p<0.05; pao2; parameters; patients; patients methods; pattern; peep; perfusion; period; phase; phi; plasma; population; position; postoperative; presence; present; pressure; pressure support; procedure; protocol; pts; pulmonary; rain; range; rate; rats; reduction; renal; resistance; respiratory; response; results; right; risk; risk patients; samples; saps; score; sepsis; septic; serum; severe; severity; shock; shock patients; signs; specific; standard; status; stay; studies; study; study group; study period; subjects; support; surgery patients; surgical; survival; survivors; syndrome; system; systemic; technique; temperature; test; therapeutic; therapy; time; tissue; total; tracheal; transplantation; trauma patients; treatment; tube; type; unit; university; use; values; variables; vascular; vein; venous; ventilation; ventricular; volume; weaning; years cache: cord-005814-ak5pq312.txt plain text: cord-005814-ak5pq312.txt item: #9 of 171 id: cord-005816-i54q5gsu author: None title: 10(th) European Congress of Trauma and Emergency Surgery: May 13–17, 2009 Antalya, Turkey date: 2009-08-06 words: 83218 flesch: 50 summary: Liberal utilization of abdominal sonography and abdominal CT scan may reduce missed acute abdomen in abdominal pain patients and appropriate radiological imaging and meticulous evaluation of the X-rays may reduce unnoticed spinal, pelvic and facial fractures in trauma patients. The e-mail noticed us, the presenting author of this abstract (Akira Endo) posted 3 or more abstract as a presenting author, however, the authors of 'Increased mortality in trauma patients with systolic hypertension' believed that Akira Endo in Department of ACCDM, TMDU, Japan surely posted this abstract only. keywords: abdomen; abdominal; acute; admission; age; aim; appendicitis; approach; area; artery; average; bleeding; blood; blunt; bone; burn; burn patients; care; cases; cause; chest; colon; complications; conclusion; control; data; days; department; diagnosis; disease; emergency; evaluation; examination; factors; female; findings; fixation; follow; fractures; general; good; group; head; healing; hospital; infection; initial; injuries; injury; introduction; knee; laparotomy; left; liver; male; management; mean; medical; methods; months; morbidity; mortality; n =; number; operation; outcome; p =; pain; patients; penetrating; perforation; period; postoperative; present; procedure; range; rate; reduction; results; right; risk; score; second; severity; stay; study; surgery; system; technique; time; tissue; total; trauma patients; treatment; type; weeks; wound; years cache: cord-005816-i54q5gsu.txt plain text: cord-005816-i54q5gsu.txt item: #10 of 171 id: cord-005881-oswgjaxz author: None title: Abstracts: 11(th) European Congress of Trauma and Emergency Surgery May 15–18, 2010 Brussels, Belgium date: 2010 words: 72013 flesch: 48 summary: The aim of this study was therefore to establish the impact of anaemia and blood transfusion on postoperative recovery of hip fracture patients. We assessed the adherence of these guidelines on the initial pre-operative management of tetanus prone open orthopaedic injuries in trauma patients admitted for surgery. keywords: acute; age; aim; analysis; approach; average; bone; care; cases; complications; conclusion; control; data; days; difference; disclosure; emergency; evaluation; failure; fixation; follow; fracture patients; fractures; good; group; head; healing; hospital; incidence; infection; injuries; injury; introduction; knee; liver; long; management; material; mean; medical; methods; months; mortality; nail; non; number; operation; operative; osteosynthesis; outcome; pain; patients; period; plate; postoperative; procedure; range; rate; reduction; relationships; repair; results; risk; score; screw; standard; stiffness; studies; study; surgery; system; technique; tibial; time; tissue; total; training; trauma patients; treatment; type; use; weeks; wound; years cache: cord-005881-oswgjaxz.txt plain text: cord-005881-oswgjaxz.txt item: #11 of 171 id: cord-005902-5zuij5i3 author: Frank, Johannes title: Necrotizing Fasciitis of the Extremities date: 2008-05-30 words: 3544 flesch: 42 summary: 1 Neutrophil extracellular traps: casting the NET over pathogenesis Invasive group A streptococcus infections Progressive necrotizing surgical infections: a unified approach The microbiology of necrotizing soft-tissue infections Predictors of mortality and limb loss in necrotizing soft tissue infections Clinical picture of the forearm after the reconstruction was performed. key: cord-005902-5zuij5i3 authors: Frank, Johannes; Barker, John H.; Marzi, Ingo title: Necrotizing Fasciitis of the Extremities date: 2008-05-30 journal: Eur J Trauma Emerg Surg DOI: 10.1007/s00068-008-8074-0 sha: doc_id: 5902 cord_uid: 5zuij5i3 Necrotizing fasciitis (NF) describes a life threatening soft tissue infection characterized by a rapid spreading infection of the subcutaneous tissue and in particular the fascia. keywords: cases; fascia; fasciitis; infections; necrotizing; skin; therapy; tissue; treatment cache: cord-005902-5zuij5i3.txt plain text: cord-005902-5zuij5i3.txt item: #12 of 171 id: cord-006229-7yoilsho author: None title: Abstracts of the 82(nd) Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) and the 18(th) Annual Meeting of the Network Clinical Pharmacology Germany (VKliPha) in cooperation with the Arbeitsgemeinschaft für Angewandte Humanpharmakologie e.V. (AGAH) date: 2016-02-06 words: 134020 flesch: 40 summary: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC) and is characterized by a metabolic shift towards enhanced aerobic glycolysis and hence, increased lactate production. Further studies will be performed to clarify whether silver ions and/or silver nanoparticles could affect the specific N-acetylation of arylamines in human cells. keywords: acid; activation; activity; addition; agents; agonist; aim; analysis; animal; anti; approach; assay; assessment; background; barrier; binding; blood; body; brain; camp; cancer; cancer cells; cardiac; cell death; cell line; cells; cgmp; changes; channels; chemical; chronic; clinical; complex; compounds; concentrations; conclusion; conditions; contrast; control; culture; current; damage; data; days; death; development; differences; different; differentiation; disease; dna; dose; drug; e.g.; effects; endothelial; enzyme; experiments; exposure; expression; factor; fibroblasts; findings; flow; fold; food; formation; fret; function; g protein; gene; germany; group; growth; health; heart; human; impact; increase; induction; inflammation; influence; inhibition; inhibitors; insulin; interaction; intracellular; kidney; levels; line; liver; loss; low; lung; mcpd; mechanisms; membrane; metabolism; metabolites; methods; mice; migration; model; mouse; mrna; nanoparticles; neurons; new; non; novel; number; oct1; order; p<0.05; parameters; pathways; patients; phosphorylation; plasma; platelet; potential; presence; present; primary; processes; products; proliferation; properties; protein; protein expression; rats; receptor; receptor activation; reduced; reduction; regulation; release; research; resistance; response; results; risk; role; samples; set; signaling; skin; small; specific; stimulation; stress; studies; study; substances; system; target; test; testing; therapy; time; tissue; total; toxicity; transcription; treatment; tumor; type; uptake; vitro; vivo; vs.; weight cache: cord-006229-7yoilsho.txt plain text: cord-006229-7yoilsho.txt item: #13 of 171 id: cord-006435-4o8uu6d5 author: Kivity, Shaye title: Evidence for the Use of Intravenous Immunoglobulins—A Review of the Literature date: 2009-07-10 words: 14153 flesch: 21 summary: Intravenous immunoglobulin treatment for Stevens-Johnson syndrome and toxic epidermal necrolysis: a prospective noncomparative study showing no benefit on mortality or progression Treatment of toxic epidermal necrolysis. An update Sarova-Pinhas I (1998) Intravenous immunoglobulin treatment in multiple sclerosis. keywords: case; disease; dose; evidence; high; immune; immunoglobulin; immunoglobulin therapy; immunoglobulin treatment; intravenous; intravenous immunoglobulin; ivig; ivig treatment; level; patients; recommendation; recommendation iia; severe; strength; syndrome; therapy; treatment; use cache: cord-006435-4o8uu6d5.txt plain text: cord-006435-4o8uu6d5.txt item: #14 of 171 id: cord-006849-vgjz74ts author: None title: 27th International Congress of the European Association for Endoscopic Surgery (EAES) Sevilla, Spain, 12–15 June 2019 date: 2019-09-13 words: 222539 flesch: 45 summary: Day after surgery patient was asymptomatic, got full oral diet. Methods: From January 2001 to March 2005 all characteristics of surgical patients with diverticular and colon adenocarcinoma colovesical fistulae were reviewed. keywords: abdominal; acute; age; aim; aims; analysis; anastomosis; anatomy; anterior; approach; artery; associated; average; background; bile; biliary; bleeding; blood; bmi; body; bowel; bypass; cancer patients; cancer surgery; cases; cholecystectomy; chronic; clinical; closure; colon; complete; complications; conclusion; control; conventional; conversion; course; data; days; defect; diagnosis; differences; disease; dissection; distal; drainage; duct; emergency surgery; endoscopic; esophageal; esophagus; evaluation; examination; experience; factors; female; fluorescence; follow; following; gastrectomy; gastric; general; good; grade; group; hepatic; hernia; history; hospital; icg; imaging; incision; intervention; intraoperative; introduction; laparoscopic; leak; learning; left; lesion; level; line; liver; loss; lymph; management; mass; mean; median; medical; mesh; methods; model; months; morbidity; mortality; need; new; node; non; normal; number; objective; open; operation; operation time; order; outcomes; p =; pain; patients; perform; period; port; position; postoperative; preoperative; present; primary; procedure; quality; rate; recurrence; reflux; repair; report; resection; results; right; risk; risk patients; robotic; safety; scan; score; short; size; sleeve; space; stage; standard; stay; step; stomach; studies; study; study group; surgeons; surgery; surgery group; surgery patients; surgical; survival; suture; symptoms; system; technique; term; time; tissue; total; training; treatment; tumor; type; use; video; wall; weight; years cache: cord-006849-vgjz74ts.txt plain text: cord-006849-vgjz74ts.txt item: #15 of 171 id: cord-007788-09t52zix author: Wallhult, Elisabeth title: Early and Acute Complications and the Principles of HSCT Nursing Care date: 2017-11-22 words: 13964 flesch: 41 summary: www.ukomic.co Guidelines for the assessment of oral mucositis in adult chemotherapy, radiotherapy and haematopoietic stem cell transplant patients Severe respiratory failure due to diffuse alveolar hemorrhage: clinical characteristics and outcome of intensive care Drug safety evaluation of defibrotide Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016 Hematopoietic cell transplantationassociated thrombotic microangiopathy: a review of pathophysiology, diagnosis, and treatment Chapter 12: Infections after HSCT. HSCT patients are particularly at risk, especially during the neutropenic period following the conditioning treatment. keywords: blood; care; cell; complications; diagnosis; disease; et al; factors; hsct; infection; need; pain; patients; risk; sepsis; signs; sos; stem; symptoms; syndrome; transplantation; treatment; vod cache: cord-007788-09t52zix.txt plain text: cord-007788-09t52zix.txt item: #16 of 171 id: cord-007798-9ht7cqhu author: Smith, Silas W. title: Drugs and pharmaceuticals: management of intoxication and antidotes date: 2010-02-25 words: 22607 flesch: 29 summary: Similarly, restricting activated charcoal (AC) administration to patients presenting to health care within the first hour post ingestion would exclude up to 90% of poisoned patients from the potential benefits of AC when administered beyond an hour [24, 33] . A small retrospective chart review found no adverse effects or allergic reactions in VPA overdose patients administered carnitine keywords: acetaminophen; acid; acute; administration; benefit; bicarbonate; calcium; cardiac; carnitine; case; channel; charcoal; concentrations; digoxin; doses; drug; effects; glucose; hours; hypoglycemia; i.v; infusion; ingestion; insulin; intoxication; leucovorin; management; methotrexate; mtx; naloxone; octreotide; oral; overdose; patients; poisoning; serum; sodium; studies; study; therapy; toxicity; treatment; use cache: cord-007798-9ht7cqhu.txt plain text: cord-007798-9ht7cqhu.txt item: #17 of 171 id: cord-009967-fyqc5bat author: Gleckman, Richard title: Cost‐Effective Antibiotic Prescribing date: 2012-01-24 words: 5939 flesch: 23 summary: In 1973, it was reported that favorable results ensued when oral antibiotic therapy was prescribed for hospitalized patients with serious infectionsz3 Fourteen patients with osteomyelitis were treated successfully with oral cephalexin after they had received a short course of parenteral cephaloridine. Therapy of osteomyelitis and suppurative arthritis High-dose dicloxacillin treatment of acute staphylococcal osteomyelitis in children Long-term follow-up of ambulatory management of osteomyelitis Success with cephalordine-cephalexin therapy Use of the serum bactericidal titer to assess the adequacy of oral antibiotic therapy in the treatment of acute hematogenous osteomyelitis Marks MI et at. keywords: antibiotic; cost; drug; home; hospital; infections; intravenous; patients; prophylaxis; therapy; treatment; use cache: cord-009967-fyqc5bat.txt plain text: cord-009967-fyqc5bat.txt item: #18 of 171 id: cord-009997-oecpqf1j author: None title: 2018 ASPHO ABSTRACTS date: 2018-03-31 words: 182444 flesch: 45 summary: Of included patients, 165 had treatment intensity of 2 (41.0%), 192 of 3 (47.8%) and 45 of 4 (11.2%). After 2 cycles of treatment patient was no longer requiring oxygen and was ambulating without assistance. keywords: acute; addition; adherence; adult patients; age; aml; aml patients; analysis; anemia; anti; average; background; baseline; biopsy; bleeding; blood; blood cell; bone; cancer; cancer patients; care; cases; cell; cell disease; center; chart; chemotherapy; childhood; children; chronic; clinical; cohort; complications; conclusion; control; count; course; cycles; data; days; death; design; development; diagnosis; differences; disease; dose; effects; efficacy; end; episodes; evaluation; events; evidence; expression; factors; failure; family; female; fever; findings; following; function; gene; grade; group; guidelines; health; hemoglobin; high; history; hospital; hsct patients; hydroxyurea; imaging; immune; impact; improvement; incidence; increase; induction; infection; initial; institution; intervention; iron; laboratory; lesions; leukemia; levels; life; literature; liver; loss; low; lymphoma; male; management; marrow; mean; median; medical; metastatic; method; months; mortality; multiple; mutations; n =; need; negative; neuroblastoma; neuroblastoma patients; neutropenia; new; non; normal; novel; number; objectives; oncology patients; outcomes; p =; pain; parents; patients; pediatric; period; platelet; population; positive; post; potential; present; presentation; primary; program; providers; range; rates; relapse; report; required; research; response; results; review; risk; risk patients; role; scd patients; scores; screening; severe; sickle; sirolimus; specific; stage; standard; states; states background; stem; studies; study; support; survival; survivors; symptoms; syndrome; term; testing; therapy; thrombocytopenia; time; total; transfusion; transplant; treatment; tumor; type; united; use; weeks; years cache: cord-009997-oecpqf1j.txt plain text: cord-009997-oecpqf1j.txt item: #19 of 171 id: cord-010078-8lkkez3n author: None title: Invited Speakers date: 2010-11-24 words: 21364 flesch: 41 summary: The SIRT1 is decreased in alveolar macrophages of smokers and COPD patients, and associated with pro-infl ammatory response through the activation of NF-κB. Understanding the complexity of infl ammatory and epigenetic regulations in chronic lung diseases may potentiate the development of novel therapies. In China, non-smokers accounted for 38.6% of COPD patients compared with 24.9% in USA and 22.9% in the UK. keywords: acute; airway; asthma; bronchitis; cancer; care; cells; chronic; copd; copd patients; cough; countries; data; diagnosis; disease; factors; function; group; health; infl; lung; new; non; patients; pleural; prevalence; pulmonary; risk; signifi; smoking; stage; studies; study; symptoms; therapy; treatment; trials; use cache: cord-010078-8lkkez3n.txt plain text: cord-010078-8lkkez3n.txt item: #20 of 171 id: cord-010570-ytv7dwr0 author: Casadevall, Arturo title: Return to the Past: The Case for Antibody-Based Therapies in Infectious Diseases date: 1995-07-17 words: 7474 flesch: 27 summary: Chemotherapy was more effective and less toxic than antibody therapy. Serum therapy reduced mortality in diphtheria, and antibody therapy continues to be used today to treat this disease keywords: antibodies; antibody; chemotherapy; human; immune; infections; intravenous; mabs; monoclonal; murine; pathogens; patients; serum; therapies; therapy; treatment; use cache: cord-010570-ytv7dwr0.txt plain text: cord-010570-ytv7dwr0.txt item: #21 of 171 id: cord-010980-sizuef1v author: None title: ECTES Abstracts 2020 date: 2020-05-11 words: 132805 flesch: 50 summary: Investigation of coagulopathies and its relevance with mortality and transfusion rates using thromboelastography in trauma patients Introduction: Inter-hospital variation in surgical intensity for trauma admissions: a multicenter cohort study L. Moore 1 , M. P. Patton 2 , I. Farhat 2 , P. A. Tardif 2 , C. Gonthier 3 , A. Belcaid 3 , F. Lauzier 2 , A. Turgeon 2 , J. Clément 2 1 Université Laval, Social and preventive medicine, québec, Canada, 2 CHU de Québec-Université-Laval, Québec, Canada, 3 Introduction: Guidelines for trauma patients are increasingly moving away from surgical management towards less invasive procedures but there is a knowledge gap on how these recommendations are influencing practice. keywords: 0.001; abdomen; abdominal; acute; admission; adult patients; age; aim; analysis; approach; average; bleeding; blood; blunt; bone; brain; cases; cause; chest; clinical; cohort; cohort study; comments; complications; conclusions; control; data; days; death; department; diagnosis; emergency; emergency surgery; factors; findings; fixation; follow; following; fractures; general; good; grade; group; head; hip; history; hospital; hospital mortality; icu; incidence; increased; injuries; injury; injury severity; introduction; investigation; iss; laparotomy; left; level; literature; male; management; material; mean; mechanism; median; medical; methods; model; months; mortality; mortality rate; neck; need; non; number; open; operative; outcomes; p =; pain; patients c; patients introduction; pelvic; period; plate; polytrauma patients; population; postoperative; pressure; primary; procedure; progressions; range; rate; reduction; results; review; right; risk; scan; score; screw; severity; shock; stay; studies; study; study introduction; surgeons; surgery; surgery patients; survival; system; technique; test; therapy; time; tissue; total; transfusion; trauma care; trauma center; trauma patients; trauma registry; trauma surgery; trauma team; treatment; type; university; use; vascular; wound; years cache: cord-010980-sizuef1v.txt plain text: cord-010980-sizuef1v.txt item: #22 of 171 id: cord-011712-fyrbe8tw author: Venkatesan, Sudhir title: Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection date: 2020-02-01 words: 4625 flesch: 33 summary: Additionally, where data were available, we defined 3 further exposure variables: NAI treatment (at any time) versus no NAI treatment, early NAI treatment (initiated within ≤2 days after symptom onset) versus no NAI treatment, and early NAI treatment versus later treatment (initiated >2 days after symptom onset). In addition, we performed secondary analyses for the following exposures: NAI treatment (at any time) versus no NAI treatment, early NAI treatment (≤48 hours after symptom onset) versus later NAI treatment (>48 hours after symptom onset), and early NAI treatment versus no NAI treatment, adjusting for propensity score, in-hospital antibiotic treatment, and corticosteroid treatment. keywords: data; days; hospital; influenza; los; nai; nai treatment; onset; patients; treatment cache: cord-011712-fyrbe8tw.txt plain text: cord-011712-fyrbe8tw.txt item: #23 of 171 id: cord-011773-vboa8xn9 author: Richards, J. A. title: Coronamolars? date: 2020-06-26 words: 653 flesch: 39 summary: https://doi.org/10.1038/s41415-020-1802-5 Dental education Sir, the last 18 months of DCT in Oral and Maxillofacial Surgery have highlighted challenges and complications presented by facial aesthetic treatments. I am unaware of any dental schools teaching facial aesthetic treatments including dermal fillers as part of the undergraduate course. keywords: dentists; training; treatments cache: cord-011773-vboa8xn9.txt plain text: cord-011773-vboa8xn9.txt item: #24 of 171 id: cord-012038-psqmqpff author: Erdem, Guliz title: Decreasing the Duration of Discharge Antibiotic Treatment Following Inpatient Skin and Soft Tissue Abscess Drainage date: 2020-02-15 words: 3135 flesch: 36 summary: We aimed to decrease the duration of discharge antibiotic treatment to less than 5 days following inpatient incision and drainage of uncomplicated abscesses. The primary goal was to decrease the duration of discharge antibiotic treatment following inpatient I&D of skin and soft tissue abscesses by discharging patients with uncomplicated abscesses after 5 or fewer days of antibiotics. keywords: abscesses; antibiotic; days; discharge; patients; skin; treatment cache: cord-012038-psqmqpff.txt plain text: cord-012038-psqmqpff.txt item: #25 of 171 id: cord-012866-p3mb7r0v author: Luo, Yan title: Predicting the treatment response of certolizumab for individual adult patients with rheumatoid arthritis: protocol for an individual participant data meta-analysis date: 2020-06-12 words: 5250 flesch: 41 summary: Previous treatment response prediction models for RA were mainly based on observational studies [7] [8] For stage 1, generally there are two types of risk models. keywords: arthritis; data; ipd; meta; model; patients; risk; stage; study; treatment cache: cord-012866-p3mb7r0v.txt plain text: cord-012866-p3mb7r0v.txt item: #26 of 171 id: cord-013830-qfvceu65 author: Ang, Juan Lyn title: A systematic review of real-world evidence of the management of macular oedema secondary to branch retinal vein occlusion date: 2020-04-20 words: 9892 flesch: 40 summary: Natural history of branch retinal vein occlusion: an evidence-based systematic review Argon laser photocoagulation for macular edema in branch vein occlusion Changes of aqueous vascular endothelial growth factor and interleukin-6 after intravitreal triamcinolone for branch retinal vein occlusion A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with standard care to treat vision loss associated with macular Edema secondary to branch retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study report 6 Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion Dexamethasone intravitreal implant in patients with macular edema related to branch or central retinal vein occlusion twelve-month study results The Royal College of Ophthalmologists. The Royal College of Ophthalmologists Ranibizumab for macular edema following branch retinal vein occlusion: six-month primary end point results of a phase III study Sustained benefits from ranibizumab for macular edema following branch retinal vein occlusion: 12-month outcomes of a phase III study Ranibizumab for macular edema due to retinal vein occlusions: long-term follow-up in the HORIZON trial Long-term outcomes in patients with retinal vein occlusion treated with ranibizumab: the RETAIN study Individualized stabilization criteria-driven ranibizumab versus laser in branch keywords: arms; bevacizumab; branch; edema; intravitreal; occlusion; outcomes; patients; secondary; studies; study; treatment; vein; world cache: cord-013830-qfvceu65.txt plain text: cord-013830-qfvceu65.txt item: #27 of 171 id: cord-015334-8p124rwp author: None title: ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts date: 2008-06-11 words: 51170 flesch: 47 summary: The main off-label indications were prevention of hemorrhagic risk of antiplatelet agent (23%), hemoglobin decrease(16%), anticoagulant co-prescription(13%), steroids co-prescription(6%). A rinse volume of 10 ml improved significantly the transit of Mopral Ò , Ogast Ò and Ogastoro Ò (+4.8%, keywords: administration; age; analysis; background; blood; care; cases; community; conclusions; control; criteria; data; days; department; design; disease; dosage; dose; drug; effects; errors; group; guidelines; health; hospital; information; interventions; level; management; mean; measures; medical; medication; months; new; non; number; nurses; objective; oral; order; outcome; outcome measures; pain; patients; period; pharmaceutical; pharmacists; pharmacy; physicians; practice; prescriptions; problems; quality; questionnaire; recommendations; results; risk; safety; setting; studies; study; therapy; time; total; treatment; use; years cache: cord-015334-8p124rwp.txt plain text: cord-015334-8p124rwp.txt item: #28 of 171 id: cord-015368-a0qz4tb9 author: None title: 48th Annual Meeting of the Austrian Society of Surgery, Graz, June 7–9, 2007 date: 2007 words: 86712 flesch: 48 summary: In an unselected cohort of surgical patients those presenting with infection prior to surgery and those undergoing abdominal surgery are at highest risk of death from infection. After resection patients should have long term follow up. keywords: acute; age; aim; analysis; aortic; approach; artery; average; background; blood; breast; bypass; cancer; cancer patients; carcinoma; cardiac; cases; cell; chemotherapy; children; colon; colorectal; complications; conclusions; control; data; days; department; der; diagnosis; die; disease; endoscopic; esophageal; experience; expression; female; findings; follow; following; function; gastric; grade; graft; group; heart; hernia; high; hospital; iii; incidence; increase; infection; injuries; laparoscopic; left; lesions; levels; liver; male; management; mean; median; medical; methods; min; months; morbidity; mortality; n ¼; nerve; non; number; operation; outcome; p ¼; pain; patients; period; postoperative; preoperative; present; procedure; quality; range; rate; repair; resection; results; right; risk; skin; stage; standard; stay; study; surgery; surgical; survival; symptoms; system; technique; term; therapy; time; tissue; total; trauma; treatment; tumor; type; valve; vs.; weight; years cache: cord-015368-a0qz4tb9.txt plain text: cord-015368-a0qz4tb9.txt item: #29 of 171 id: cord-015369-72cjogxz author: None title: 50th Annual Meeting of the Austrian Society of Surgery. Vienna, June 18–20, 2009. Guest Editors: Albert Tuchmann, Erhard Schwanzer, Benedikt Walzel date: 2009 words: 71211 flesch: 45 summary: eröffneten Aortenbogen in die Aorta deszendens vorgeschoben, anschließend wird mit der Dacron Hälfte der Prothese der Aortenbogen und die distale Aorta aszendens ersetzt. Das postoperative Kontroll-und Stimulationsschema beträgt 9 Monate, in denen die Aussprossung der Axone in monatlichen Abständen evaluiert wird. keywords: abteilung; acute; age; aim; allen; als; analyse; analysis; anastomosis; aorta; aortic; approach; artery; auch; auf; auf eine; aufgrund; aus; background; behandlung; bei der; bei einer; beiden; beim; betrug; biopsy; bis; blood; bmi; body; breast; bypass; cancer; cancer patients; carcinoma; cardiac; cases; cells; chemotherapy; children; chirurgische; cle; clinical; closure; colon; complications; conclusions; control; das; dass; data; days; death; dem; department; der; der behandlung; der gruppe; der operation; des; diagnosis; die; dieser; disease; donor; durch; durchgeführt; effect; eine; endoscopic; erfolgte; ergebnisse; es zu; esophageal; esophagus; experience; expression; failure; fall; female; findings; fistula; fixation; follow; formation; function; fällen; für; für die; gastric; gerd patients; graft; group; grundlagen; gruppe; hand; healing; heart; hernia; hospital; iii; incidence; infection; invasive; ist; ist der; ist die; ist eine; jahren; jedoch; kam; kann; kein; komplikationen; konnte; können; laparoscopic; left; length; levels; life; liver; loss; management; mean; median; mesh; metastases; methodik; methods; min; mit; mit der; mit einer; mittels; model; monaten; months; morbidity; mortality; n ¼; nach; nach der; new; nicht; node; non; number; nur; oder; ohne; open; operation; outcome; p ¼; pain; patienten; patienten mit; patients; period; perioperative; pgd; placement; porcine; positive; postoperative; present; primary; procedure; protein; pulmonary; quality; rahmen; rahmen der; range; rate; recurrence; reflux; removal; repair; report; resection; response; results; right; risk; schlussfolgerungen; score; serum; sich; sich der; sich die; sind; skin; sowie; stage; standard; stay; stent; studie; study; surgery; survival; symptoms; system; technik; technique; term; therapie; therapie der; therapy; thoracic; time; tissue; total; transplantation; treatment; tumor; type; und; und bei; und der; und die; und eine; und mit; unserer; unter; use; v.a.c; valve; von; von der; vor; vs.; wall; war; waren; weeks; wegen; weight; werden; werden die; werden und; wird; wound; wurde; wurde der; wurde eine; während; years; zeigte; zu einer; zum; zur; zwischen; über cache: cord-015369-72cjogxz.txt plain text: cord-015369-72cjogxz.txt item: #30 of 171 id: cord-016280-d47e3art author: Friedberg, Joseph S. title: Pleura: Anatomy, Physiology, and Disorders date: 2008 words: 14507 flesch: 42 summary: Baltimore: Lippincott Williams and Wilkins Solitary fibrous tumor of the pleura The role of Alimta in the treatment of malignant pleural mesothelioma: an overview of preclinical and clinical trials Malignant mesothelioma-the UK experience Malignant pleural mesothelioma New developments about the association of SV40 with human mesothelioma Multimodality management of malignant pleural mesothelioma Gene expression profiles predict survival and progression of pleural mesothelioma Chemotherapy for malignant pleural mesothelioma: past results and recent developments Chemotherapy for malignant pleural mesothelioma: past results and recent developments Phase IT trial of pleural photodynamic therapy and surgery for patients with non-smallcell lung cancer with pleural spread Recursive partitioning analysis of 1999 Radiation Therapy Oncology Group (RTOG) patients with locally-advanced non-small-cell lung cancer (LA-NSCLC): identification of five groups with different survival Prognostic value of pleural effusion in patients with non-small cell lung cancer Revisions in the International System for Staging Lung Cancer Indications for pleurectomy in malignant effusion Neoadjuvant chemotherapy and operations in the treatment of lung cancer with pleural effusion Malignant pleural effusion in non-small cell lung cancer-time for a stage revision Multimodality treatment programs for malignant pleural mesothelioma using highdose hemithorax irradiation Extrapleural pneumonectomy for lung cancer with carcinomatous pleuritis Prognosis of resected non-small cell lung cancer patients with carcinomatous pleuritis of minimal disease Implications of staging in lung cancer Intraoperative intrapleural hypotonic cisplatin treatment for carcinomatous pleuritis Pleuropneumonectomy and postoperative adjuvant chemotherapy for carcinomatous pleuritis in primary lung cancer: a case report of long-term survival Comparison of pleuropneumonectomy and limited surgery for lung cancer with pleural dissemination Phase IT trial of pleural photodynamic therapy and surgery for patients with non-smallcell lung cancer with pleural spread Gray's Anatomy Minimal Access Surgery in Oncology Chemical pleurodesis for malignant pleural effusion Comparison of thoracic drainage vs. immediate or delayed needle aspiration Treatment of pneumothoraces utilizing small caliber chest tubes The performance of four pleural drainage systems in an animal model of bronchopleural fistula Focal reexpansion pulmonary edema after drainage of large pleural effusions: clinical evidence suggesting hypoxic injury to the lung as the cause of edema Reexpansion pulmonary edema Complications in Cardiothoracic Surgery Smoking and the increased risk of contracting spontaneous pneumothorax Treatment of spontaneous pneumothorax: a more aggressive approach? Management of spontaneous pneumothorax Secondary spontaneous pneumothorax Significance of iatrogenic pneumothoraces Pulmonary Diseases and Disorders Pleural effusions: the diagnostic separation of transudates and exudates Focal reexpansion pulmonary edema after drainage of large pleural effusions: clinical evidence suggesting hypoxic injury to the lung as the cause of edema Transudative effusions Hepatic hydrothorax Outcome analysis of cirrhotic patients undergoing chest tube placement Recurrent pleural effusion complication liver cirrhosis Cytologically proved malignant pleural effusions: distribution of transudates and exudates Management of malignancyassociated pleural effusion: current and future treatment strategies Efficacy of short term versus long term tube thoracostomy drainage before tetracycline pleurodesis in the treatment of malignant pleural effusions Distribution of talc suspension during treatment of malignant pleural effusion with talc pleurodesis Pleurodesis for malignant pleural effusions (Cochrane Review) Outpatient management of malignant pleural effusion by a chronic indwelling catheter Survival and talc pleurodesis in metastatic pleural carcinoma, revisited. keywords: air; cancer; cavity; chest; chest tube; disease; drainage; effusion; fluid; lung; patient; pleura; pleurodesis; pneumothorax; pressure; pulmonary; space; surgery; treatment; tube cache: cord-016280-d47e3art.txt plain text: cord-016280-d47e3art.txt item: #31 of 171 id: cord-016283-b6yywn9f author: Hasan, Ashfaq title: Clinical Aspects and Principles of Management of Tuberculosis date: 2019-08-07 words: 6934 flesch: 41 summary: Disseminated TB Disseminated TB should always raise suspicion for an accompanying immune deficiency such as HIV disease. In a recent study done on TB patients requiring ICU admission, mortality was 72.5% (Tatar et al. 2018 ). keywords: agents; children; diagnosis; disease; drug; hiv; mdr; patients; resistance; rifampicin; therapy; treatment; tuberculosis cache: cord-016283-b6yywn9f.txt plain text: cord-016283-b6yywn9f.txt item: #32 of 171 id: cord-016290-l592k753 author: Finke, Jürgen title: Hematology and Hemostasis date: 2008 words: 11733 flesch: 25 summary: Increased serum levels of hematopoietic growth factors: G-CSF (granulocyte colony-stimulating factor), TPO (thrombopoietin), M-CSF, and erythropoietin; SCF (stem cell factor) not increased • Myelodysplasia with hypoplastic bone marrow (7 Chap. In patients with clinically relevant recurrent infections, G-CSF may be used as long-term treatment • Use of other hematopoietic growth factors in clinical studies: GM-CSF, IL-3, stem cell factor (SCF) • keywords: acid; anemia; bleeding; blood; bone; cases; cell; chap; chronic; coagulation; count; days; deficiency; disease; factor; hemolysis; hemolytic; heparin; iron; normal; patients; platelet; protein; risk; thrombocytopenia; treatment; vitamin; vwf cache: cord-016290-l592k753.txt plain text: cord-016290-l592k753.txt item: #33 of 171 id: cord-016559-tqd7m2i1 author: Zheng, Yi title: Application in Medicine Systems date: 2014-10-28 words: 19358 flesch: 48 summary: Xing [8] reported the application of CDI in the treatment of 120 patients (treatment group: 80 patients, control group: 40 patients) with coronary heart disease and angina pectoris and blood stasis based on temporal rhythm. The results showed that there were 2 cases with a clinical cure, 8 cases with marked effect, 10 cases with improvement, 7 cases without effect, and the total effective rate was 91 % in treatment group. keywords: blood; cases; cdi; compound danshen; control group; danshen; danshen injection; danshen treatment; day; days; disease; drip; effect; function; groups; heart; injection; patients; rate; results; total; treatment group cache: cord-016559-tqd7m2i1.txt plain text: cord-016559-tqd7m2i1.txt item: #34 of 171 id: cord-016855-hqs94hfa author: Simpson, William M. title: Pesticides date: 2006 words: 4762 flesch: 45 summary: Treatment of paraquat ingestion is aimed at several points along the toxicity pathway-removing toxin from the GI tract, increasing excretion from the blood, and preventing pulmonary damage with anti-inflammatory agents. Renal and hepatic dysfunction may occur with large ingestions. keywords: decontamination; exposure; herbicides; hours; ingestion; poisoning; produce; skin; symptoms; toxicity; treatment cache: cord-016855-hqs94hfa.txt plain text: cord-016855-hqs94hfa.txt item: #35 of 171 id: cord-016960-xhzvp35g author: Berencsi, György title: Fetal and Neonatal Illnesses Caused or Influenced by Maternal Transplacental IgG and/or Therapeutic Antibodies Applied During Pregnancy date: 2012-03-08 words: 17740 flesch: 31 summary: Experimental systemic lupus erythemetosus could be induced in mice using immunisation with anti-idiotype antibodies (Ab2) specific to the anti-DNA-specific monoclonal antibodies (Mendlovic et al. 1989) . MELIMMUNE: anti-idiotype antibody that mimic the high molecular weight chondroitin sulfate proteoglycan antigen of melanoma cells (Pride et al. 1998; Murray et al. 2004; keywords: activity; anti; antibodies; antibody; antigen; arthritis; associated; blood; cancer; cells; development; disease; et al; factor; growth; human; idiotype; igg; immune; infection; inflammatory; infliximab; lupus; monoclonal; mothers; necrosis; neonatal; nieri; nieri et; patients; pregnancy; receptor; rheumatoid; risk; sle; specific; study; syndrome; therapy; tnf; treatment; tumor; virus; women cache: cord-016960-xhzvp35g.txt plain text: cord-016960-xhzvp35g.txt item: #36 of 171 id: cord-017142-vx3rgs4r author: Nair, Ranjit title: What the Intensivists Need to Know About Critically Ill Myeloma Patients date: 2019-07-09 words: 9346 flesch: 29 summary: In: Decision making in medicine A pilot randomised comparison of dexamethasone 96 mg vs 16 mg per day for malignant spinal-cord compression treated by radiotherapy: TROG 01.05 Superdex study Plasmablastic morphologyan independent prognostic factor with clinical and laboratory correlates: Eastern Cooperative Oncology Group (ECOG) myeloma trial E9486 report by the ECOG Myeloma Laboratory Group Light-chain cardiac amyloidosis: strategies to promote early diagnosis and cardiac response Outcome and incidence of appropriate implantable cardioverterdefibrillator therapy in patients with cardiac amyloidosis Hyperviscosity in plasma cell dyscrasias Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma Renal thrombotic microangiopathy and podocytopathy associated with the use of carfilzomib in a patient with multiple myeloma Bortezomib and heart failure: case-report and review of the French Pharmacovigilance database Risk of early mortality in patients with newly diagnosed multiple myeloma Multiple intraparenchymal brain plasmacytomas with spontaneous intratumoral hemorrhage Treatment of acute renal failure secondary to multiple myeloma with chemotherapy and extended high cut-off hemodialysis The pathogenesis and diagnosis of acute kidney injury in multiple myeloma Early reduction of serum-free light chains associates with renal recovery in myeloma kidney Immunosuppression and infection in multiple myeloma Discrimination of metastatic from acute osteoporotic compression spinal fractures with MR imaging Diffuse pulmonary parenchymal involvement in multiple myeloma: antemortem diagnosis Nonspecific interstitial pneumonitis after bortezomib and thalidomide treatment in a multiple myeloma patient Multiple myeloma with myelomatous pleural effusion: a case report and review of the literature Plasmapheresis in the treatment of renal failure associated with multiple myeloma Review of 1027 patients with newly diagnosed multiple myeloma Salmon calcitonin in the acute management of hypercalcemia Vertebral compression fractures in multiple myeloma Distribution and appearance at MR imaging Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer Narrative review: furosemide for hypercalcemia: an unproven yet common practice Use of abdominal fat tissue aspirate in the diagnosis of systemic amyloidosis Acute tubular necrosis in a patient with myeloma treated with carfilzomib Implantable cardioverter defibrillators in patients with cardiac amyloidosis A 2011 updated systematic review and clinical practice guideline for the management of malignant extradural spinal cord compression Multiple myeloma causing interstitial pulmonary infiltrates and softtissue plasmacytoma Myeloma in patients younger than age 50 years presents with more favorable features and shows better survival: an analysis of 10 549 patients from the International Myeloma Working Group Central nervous system involvement in multiple myeloma patients in the era of novel therapies (P07.005) Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: a pooled analysis of two randomized, controlled clinical trials Effectiveness of radiation therapy without surgery in metastatic spinal cord compression: final results from a prospective trial Multiple myeloma invasion of the central nervous system Proliferative activity of myeloma cells determined by Ki-67 antibody: biological and clinical significance Acute respiratory distress syndrome due to pulmonary involvement by neoplastic plasma cells in multiple myeloma Hyperviscosity syndrome in plasma cell dyscrasias Acute pancreatitis secondary to hypercalcemia of multiple myeloma Effect of plasmapheresis on hyperviscosity-related retinopathy and retinal hemodynamics in patients with Waldenstrom's macroglobulinemia Cardiac amyloidosis and its new clinical phenotype: heart failure with preserved ejection fraction Corticosteroids as adjunctive therapy for diffuse alveolar hemorrhage associated with bone marrow transplantation Acute tachypnea during mechanical ventilation in a 62-year-old man with multiple myeloma involving the spinal cord Optimizing the management of patients with spinal myeloma disease Risk factors for early death in patients undergoing treatment for multiple myeloma Prophylactic low-dose aspirin is effective antithrombotic therapy for combination treatments of thalidomide or lenalidomide in myeloma Is elevated plasma B-natriuretic peptide in amyloidosis simply a function of the presence of heart failure? Infections in patients with multiple myeloma in the era of high-dose therapy and novel agents Unexpected cardiotoxicity in haematological bortezomib treated patients Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgenindependent prostate cancer Cerebral infarction in IgG multiple myeloma with hyperviscosity Meningeal and cerebral involvement in multiple myeloma patients Randomized phase II trial comparing different doses of the bisphosphonate ibandronate in the treatment of hypercalcemia of malignancy Efficacy and safety of ibandronate in the treatment of hypercalcemia of malignancy: a randomized multicentric comparison to pamidronate Continued survival gains in recent years among critically ill myeloma patients Acute respiratory distress syndrome with pulmonary calcification in two patients with B cell malignancies Immunodeficiency and immunotherapy in multiple myeloma Is surgery required in the management of spinal cord compression in myeloma patients? Despite having increased life expectancy now, the majority of MM patients ultimately develop resistant subclones, leading to disease progression and disease-related complications. keywords: acute; amyloidosis; bortezomib; cardiac; diagnosis; disease; failure; hypercalcemia; involvement; light; myeloma; patients; renal; risk; symptoms; syndrome; therapy; treatment cache: cord-017142-vx3rgs4r.txt plain text: cord-017142-vx3rgs4r.txt item: #37 of 171 id: cord-017393-kx8kmdej author: Herbers, Alexandra title: Acute Myelogenous Leukemia and Febrile Neutropenia date: 2009-08-31 words: 13297 flesch: 27 summary: A review of 55 cases Cytosine arabinoside as a major risk factor for Streptococcus viridans septicemia following bone marrow transplantation: a 5-year prospective study Bacteremia due to viridans streptococci in neutropenic patients: a review Mucosal barrier injury: biology, pathology, clinical counterparts and consequences of intensive treatment for haematological malignancy: an overview Clostridium septicum sepsis and neutropenic enterocolitis in a patient treated with intensive chemotherapy for acute myeloid leukemia Clostridium septicum septicemia with identical metastatic myonecroses in a granulocytopenic patient Incidence and significance of Clostridium difficile in hospitalized cancer patients Clostridium difficile in haematological malignancy Epidemiology and prevention of Clostridium difficile infection in a leukemia unit The epidemiology of Clostridium difficile with use of a typing scheme: nosocomial acquisition and cross-infection among immunocompromised patients Clostridium difficile infection in patients with neutropenia Toxoplasmosis of the central nervous system Hyperinfection syndrome with strongyloidiasis New b-lactams: new problems for the internist Bacteremia due to Stenotrophomonas (Xanthomonas) maltophilia: a prospective multicenter study of 91 episodes Opportunistic mycoses in the immunocompromised host: experience at a cancer center and review Cutaneous lesions in disseminated candidiasis mimicking ecthyma gangrenosum Pseudomonas bacteremia: retrospective analysis of 410 episodes Intradermal bullous dermatitis due candidiasis in an immunocompromised patient Atypical bullous pyoderma gangrenosum associated with myeloid malignancies Sweet's syndrome and malignancy Concomitant illness in patients treated for Hodgkin's disease Disseminated varicella at autopsy in children with cancer Varicella zoster virus infections: biology, natural history, treatment and prevention Ultrasound screening for internal jugular vein thrombosis aids the detection of central venous catheter-related infections in patients with haemato-oncological diseases: a prospective observational study Periodontal infections in patients with acute nonlymphocytic leukemia: prevalence of acute exacerbations Oral infections and fever in immunocompromised patients with haematologic malignancies Anaerobic bacteremia in a cancer center Infections with herpes simplex viruses Respiratory disease in the immunosuppressed patient Potential sites of infection that develop in febrile neutropenic patients Pneumocystis carinii pneumonia in cancer patients Successful intermittent chemoprophylaxis for Pneumocystis carinii pneumonitis Respiratory syncytial virus pneumonia in hospitalized adult patients with leukemia Community respiratory virus infections among hospitalized adult bone marrow transplant recipients Pseudomonas septicemia: incidence, epidemiology, prevention and therapy in patients with advanced cancer Epidemiology and outcome of Pseudomonas aeruginosa bacteremia, with special emphasis in the influence of antibiotic treatment. A European Organization for Research and treatment of Cancer-International Antimicrobial Therapy Group Study of secondary infections in febrile, neutropenic patients with cancer Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia Empiric antifungal therapy in febrile neutropenic patients International conference for the development of a consensus on the management and prevention of severe candidal infections Micafungin Invasive Candidiasis Working Group et al (2007) Micafungin versus liposomal amphotericin B for candidaemia and invasive candidosis: a phase III randomised double-blind trial Voriconazole versus a regimen of amphotericin B followed by fluconazole for candidaemia in non-neutropenic patients: a randomised non-inferiority trial Echinocandins -first-choice or first-line therapy for invasive candidiasis? Detection of circulating candida enolase by immunoassay in patients with cancer and invasive candidiasis Sandwich enzyme-linked immunosorbent assay compared with Pastorex latex agglutination test for diagnosing invasive aspergillosis in immunocompromised patients Fungal infections in recipients of hematopoietic stem cell transplants: results of the SEIFEM B-2004 study -Sorveglianza Epidemiologica Infezioni Fungine nelle Empatie Maligne Clinical evaluation and reproducibility of the Pastorex Aspergillus antigen latex agglutination test for diagnosing invasive aspergillosis Galactomannan and computed tomography-based preemptive antifungal therapy in neutropenic patients at risk of invasive fungal infection: a prospective feasibility study Between over-and undertreatment of invasive fungal disease Presumptive treatment strategy for aspergillosis in allogeneic haematopoietic stem cell transplant recipients Imaging findings in acute invasive pulmonary aspergillosis: clinical significance of the halo sign Invasive pulmonary aspergillosis in acute leukemia: characteristics findings on CT, the CT halo sign, and the role of CT in early diagnosis Improved management of invasive pulmonary Aspergillosis in neutropenic patients using early thoracic computed tomographic scan and surgery Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients Zygomycosis in a tertiarycare cancer center in the era of Aspergillus-active antifungal therapy: a casecontrol observational study of 27 recent cases Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia AmBiLoad keywords: acute; agents; antibiotic; antifungal; cancer; cases; fever; gram; infection; leukemia; negative; neutropenic; patients; pulmonary; regimen; results; risk; therapy; treatment; use cache: cord-017393-kx8kmdej.txt plain text: cord-017393-kx8kmdej.txt item: #38 of 171 id: cord-017702-v46ye328 author: Ganguly, Nirmal Kumar title: Pharmacogenomics and Personalized Medicine for Infectious Diseases date: 2013-06-11 words: 16571 flesch: 34 summary: From the several RNAi screenings in human and in fruit fl y cells, only 300 host factors were validated from about 10,000 and 20,000 targets identifi ed in the initial screen (Agaisse et al. 2005 ; Brass et al. 2008 ; Konig et al. 2008 ; Krishnan et al. 2008 ; Zhou et al. 2008 ) . It has been observed in the case of measles vaccination that only 10 % of the population was seronegative and clustered in family (Poland 1999a , b ; Poland et al. 1999c ). keywords: acetylators; activity; discovery; disease; drug; enzymes; et al; gene; genome; hepatotoxicity; hla; host; human; infection; isoniazid; leishmaniasis; major; malaria; nat2; pathogen; patients; polymorphism; population; protein; resistance; response; risk; slow; studies; study; susceptibility; technologies; treatment; tuberculosis cache: cord-017702-v46ye328.txt plain text: cord-017702-v46ye328.txt item: #39 of 171 id: cord-018239-n7axd9bq author: Rusoke-Dierich, Olaf title: Travel Medicine date: 2018-03-13 words: 8534 flesch: 57 summary: If diarrhoea contains blood or mucus in combination of high fever for more than 2 days, more thorough assessment is required. Severe cases show high fever, neck stiffness, photophobia, headache, disorientation, coma, convulsions, spastic paralysis or death. keywords: blood; countries; days; diagnosis; disease; fever; incubation; infections; malaria; phase; risk; symptoms; treatment; vaccination; weeks; years cache: cord-018239-n7axd9bq.txt plain text: cord-018239-n7axd9bq.txt item: #40 of 171 id: cord-018557-iuu38yes author: Mainous, Arch G. title: Upper Respiratory Infections and Acute Bronchitis date: 2009-09-10 words: 7113 flesch: 39 summary: A meta-analysis Diagnosis and antibiotic treatment of acute otitis media: Report from International Primary Care Network Diagnosis and management of acute otitis media Trends in doctor consultations, antibiotic prescription and specialist referrals for otitis media in children Trends in otitis media treatment and relapse National trends in emergency department antibiotic prescribing in children with acute otitis media Otitis media in children: To treat or not to treat? Wait-and-see prescription for the treatment of acute otitis media: A randomized controlled trial Management of acute otitis media by primary care physicians: Historically, acute otitis media has been one of the most common pediatric conditions seen in primary care. keywords: acute; antibiotics; bronchitis; children; group; media; otitis; patients; pharyngitis; sinusitis; treatment cache: cord-018557-iuu38yes.txt plain text: cord-018557-iuu38yes.txt item: #41 of 171 id: cord-018620-3kqx8arn author: Rueda, Mario title: Hepatic Failure date: 2016-10-09 words: 13815 flesch: 42 summary: Besides parkinsonian movements and tremors, Kayser-Fleischer rings, psychiatric alterations, and renal problems, Wilson's disease will present with liver disease: cirrhosis, chronic failure without cirrhosis, and acute liver failure. Epidemiology of acute liver failure East meets west: acute liver failure in the global village The electroencephalograph in liver disease Low myo-inositol and high glutamine levels in brain are associated with neuropsychological deterioration after induced hyperammonemia Interorgan ammonia, glutamate, and glutamine trafficking in pigs with acute liver failure Branched-chain amino acids in liver diseases An interaction between benzodiazepines and neuroactive steroids at GABA A receptors in cultured hippocampal neurons Liver function, cerebral blood flow autoregulation, and hepatic encephalopathy in fulminant hepatic failure Difficult management problems in fulminant hepatic failure Incidence and pathophysiology of pulmonary edema in fulminant hepatic failure Pulmonary vascular complications of liver disease Hepatopulmonary syndrome: role of nitric oxide and clinical aspects Hepatorenal syndrome: pathophysiology and management Hepatorenal syndrome: a dreaded complication of end-stage liver disease Coagulopathy in liver diseases Mechanisms of water and sodium retention in cirrhosis and the pathogenesis of ascites Acute liver failure Acute liver failure Risk factors and outcomes of acute kidney injury in patients with acute liver failure Diagnosis and treatment of acute renal failure in patients with cirrhosis Lactic acidosis: recognition, kinetics, and associated prognosis Lactic acidosis Too much lactate or too little liver? Intensive care management of acute liver failure Patients with acute on chronic liver failure display sepsis-like immune paralysis Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess Effects of antimicrobial prophylaxis and blood stream infections in patients with acute liver failure: a retrospective cohort study The systemic inflammatory response syndrome in acute liver failure Infection and the progression of hepatic encephalopathy in acute liver failure Jaundice in older children and adolescents Update on the treatment of the pruritus of cholestasis Acute liver failure Medical palliation of the jaundiced patient with pruritus Acute hepatitis C AASLD position paper : the management of acute liver failure : update Propofol to control intracranial pressure in fulminant hepatic failure Management of fulminant hepatic failure in the USA: results from a survey of 14 liver transplant programs The safety and value of extradural intracranial pressure monitors in fulminant hepatic failure The American experience with transplantation for acute liver failure Ammoniainduced brain edema and intracranial hypertension in rats after portacaval anastomosis Complications of intracranial pressure monitoring in fulminant hepatic failure Cerebral and cardiovascular responses to changes in head elevation in patients with intracranial hypertension Lactulose therapy in acute liver failure Efficacy of L-ornithine L-aspartate in acute liver failure: a double-blind, randomized. keywords: acetaminophen; acute; alf; ascites; bleeding; changes; cirrhosis; cld; disease; encephalopathy; failure; hepatic; hepatitis; infection; liver; liver failure; management; patients; results; serum; system; therapy; transplantation; treatment cache: cord-018620-3kqx8arn.txt plain text: cord-018620-3kqx8arn.txt item: #42 of 171 id: cord-019347-tj3ye1mx author: None title: ABSTRACT BOOK date: 2010-02-19 words: 108161 flesch: 50 summary: in allergic patients and 250 and 500 ug. In allergic patients after histamine threshold challenge mean decrease was for FEV1 19, 2% and for FEV1/VC 17, 3%. keywords: age; airway; allergen; allergic; allergy; allergy asthma; analysis; anti; antibody; asthma; asthma control; asthma diagnosis; asthma patients; asthma symptoms; atopic; background; baseline; blood; care; case; cd4; cells; chest; children; chronic; conclusion; control; daily; data; day; days; deficiency; desensitization; diagnosis; disease; dose; drug; effect; efficacy; evaluation; exposure; female; following; food; function; group; histamine; history; hours; ics; ige; igg; immune; improvement; increase; infections; inflammatory; introduction; levels; life; low; lung; male; mean; medical; medication; methods; minutes; months; nasal; negative; new; non; normal; number; objective; ova; patients; period; persistent; placebo; pollen; population; positive; prednisone; prevalence; prick; primary; production; pulmonary; quality; rate; reactions; recurrent; report; response; results; rhinitis; rhinitis patients; risk; serum; severity; significant; skin; specific; spray; studies; study; subjects; symptoms; syndrome; testing; tests; therapy; time; total; treatment; urticaria; use; visits; weeks; wheezing; years cache: cord-019347-tj3ye1mx.txt plain text: cord-019347-tj3ye1mx.txt item: #43 of 171 id: cord-021453-vf8xbaug author: Dysko, Robert C. title: Biology and Diseases of Dogs date: 2007-09-02 words: 42005 flesch: 46 summary: Preventing laboratory animals from contacting ticks is the primary means to avoid monocytic ehrlichiosis in research dogs. For this reason, medical treatment of heartworm disease is not usually attempted in research dogs. keywords: acute; adult; age; animals; areas; beagles; bitch; blood; body; canine; canis; cases; catheter; cause; cells; complications; control; days; diagnosis; differential; disease; dogs; epizootiology; et al; etiology; findings; heartworm; host; hypothyroidism; infection; laboratory; lesions; months; pathogenesis; prevention; puppies; research; result; setting; signs; skin; stage; studies; study; systemic; therapy; tick; time; tissue; transmission; treatment; tumors; use; veterinary; weeks; weight; wound cache: cord-021453-vf8xbaug.txt plain text: cord-021453-vf8xbaug.txt item: #44 of 171 id: cord-021527-1etvgoxc author: Ellis, Christine title: Ferrets date: 2009-05-15 words: 22603 flesch: 52 summary: If complete obstruction is present ferrets often appear lethargic and anorexic, and may not demonstrate obvious signs of dysuria. Other ferrets may develop nonpersistent, self-limiting disease and fully recover. keywords: administer; age; anemia; animal; blood; body; bone; cats; cause; cbc; chapter; cysts; days; diagnosis; disease; examination; ferrets; gland; gland disease; insulinoma; key; marrow; needle; perform; point; serum; signs; surgery; therapy; treatment; use; weeks cache: cord-021527-1etvgoxc.txt plain text: cord-021527-1etvgoxc.txt item: #45 of 171 id: cord-021555-rrverrsj author: Delano, Margaret L. title: Biology and Diseases of Ruminants: Sheep, Goats, and Cattle date: 2007-09-02 words: 71795 flesch: 48 summary: In less severe outbreaks or individual animal disease, definitive diagnosis may never be made. Therefore, they should be housed in groups or at least within eyesight and hearing of other animals. keywords: abortion; acute; addition; adult; age; animals; areas; blood; body; bovine; breeding; breeds; calves; cases; cattle; cause; cells; chronic; colostrum; condition; control; copper; cows; dairy; days; death; diagnosis; diarrhea; differential; disease; edema; environment; epizootiology; etiology; ewes; feces; feed; fever; findings; flock; form; gastrointestinal; goats; herd; host; immunity; infection; kids; lambs; lesions; levels; liver; loss; management; mastitis; milk; months; mortality; necropsy; organism; pathogenesis; period; pregnancy; prevention; production; research; result; rumen; ruminants; sheep; signs; skin; species; states; time; tissues; tract; transmission; treatment; type; united; vaccination; vaccine; viral; virus; water; weeks; weight; young cache: cord-021555-rrverrsj.txt plain text: cord-021555-rrverrsj.txt item: #46 of 171 id: cord-021713-e0hzcag6 author: None title: Ribavirin date: 2015-10-21 words: 10946 flesch: 34 summary: A randomized double-blind study A controlled trial of aerosolized ribavirin in infants receiving mechanical ventilation for severe respiratory syncytial virus infection Adverse effects and other safety aspects of the hepatitis C antivirals Iatrogenic hyperpigmentation in chronically infected hepatitis C patients treated with pegylated interferon and ribavirin Anecdotes that provide definitive evidence Severe autoimmune hemolytic anemia complicated with liver decompensation and invasive aspergillosis in a patient with chronic hepatitis C during treatment with peg-interferon-a and ribavirin Pneumonitis as a consequence of (peg)interferon-ribavirin combination therapy for hepatitis C: a review of the literature Development of ocular myasthenia during pegylated interferon and ribavirin treatment for chronic hepatitis C Pleural effusion associated with pegylated interferon alpha and ribavirin treatment for chronic hepatitis C Pegylated interferon and ribavirin therapy for hepatitis C causing cataract Pegylated IFN-alpha2b plus ribavirin as therapy for chronic hepatitis C in HIV-infected patients Hepatitis C virus RNA kinetics during the initial 12 weeks treatment with pegylated interferon-alpha 2a and ribavirin according to virological response Alpha interferon and ribavirin combination therapy of chronic hepatitis D HIV/hepatitis C virus-coinfected virologic responders to pegylated interferon and ribavirin therapy more frequently incur interferon-related adverse events than nonresponders do Should living donor liver transplantation be offered to patients with hepatitis C virus cirrhosis? The effect and safety of the treatment of recurrent hepatitis C infection after orthotopic liver transplantation with pegylated interferon a2b and ribavirin Side effects of the therapy with peginterferon and ribavirin in chronic hepatitis C: a small audit Does interferon and ribavirin combination therapy increase the rate of treatment response in children with hepatitis C? Effects of adding ribavirin to interferon to treat chronic hepatitis C infection: a systematic review and meta-analysis of randomized trials Treatment of hepatitis C virus-related systemic vasculitis PEGylated interferon alfa-2b and ribavirin treatment in patients with hepatitis C virus-related systemic vasculitis Chronic cough associated with interferon/ribavirin therapy for hepatitis C Dyspnoea in patients with chronic hepatitis C treated with pegylated interferon and ribavirin Bronchial casts attributed to the use of pegylated interferon and ribavirin Expectoration of large bronchial casts secondary to the treatment of chronic hepatitis C with pegylated interferon and ribavirin Severe migraine headaches are caused by ribavirin but not by interferon alpha-2B in combination therapy for chronic hepatitis C Progressive multifocal leukoencephalopathy as a complication of hepatitis C virus treatment in an HIVnegative patient Recovery after L-DOPA treatment in peginterferon and ribavirin induced parkinsonism Bell's palsy associated with chronic HCV infection before and during peginterferon alfa and ribavirin therapy Seizures during pegylated interferon and ribavirin therapy for chronic hepatitis C: observations from the WIN-R trial Trombosis venosa retiniana asociada a peginterferó n alfa 2b má s ribavirina en un paciente con hepatitis C cró nica Incidence and risk factors of retinopathy in Egyptian patients with chronic hepatitis C virus treated with pegylated interferon plus ribavirin Retinopatía asociada a interferó n pegilado y ribavirina en pacientes con hepatitis C Retinopathy associated with pegylated interferon and ribavirin causing permanent visual impairment in a patient with chronic hepatitis C Branch retinal artery occlusion and central retinal vein occlusion associated with pegylated interferon plus ribavirin combination therapy for chronic hepatitis C Serous retinal detachments complicating interferon-alpha and ribavirin treatment in patients with hepatitis C Vogt-Koyanagi-Harada disease occurring during pegylated interferon-alpha2b and ribavirin combination therapy for chronic hepatitis C Anterior ischemic optic neuropathy in a patient with hepatitis C treated with interferon-alpha and ribavirin Retinopathy associated with pegylated interferon and ribavirin treatment for chronic hepatitis C Interferonalpha-2b/ribavirin-induced vestibulocochlear toxicity with dysautonomia in a chronic hepatitis C patient Reversible sudden sensorineural hearing loss during chronic hepatitis C treatment with pegylated interferon/ ribavirin Pegylated interferon/ribavirin-associated sudden hearing loss in a patient with chronic hepatitis C in Brazil keywords: alfa; anemia; chronic; chronic hepatitis; combination; hepatitis; infection; interferon; months; patients; peginterferon; ribavirin; therapy; treatment; virus; weeks; year cache: cord-021713-e0hzcag6.txt plain text: cord-021713-e0hzcag6.txt item: #47 of 171 id: cord-021770-zn7na974 author: Slifka, Mark K. title: Passive Immunization date: 2017-07-17 words: 12151 flesch: 13 summary: Euro Surveill Emergence of new forms of totally drug-resistant tuberculosis bacilli: super extensively drug-resistant tuberculosis or totally drug-resistant strains in iran Serum therapy for tuberculosis revisited: reappraisal of the role of antibody-mediated immunity against Mycobacterium tuberculosis The treatment of tuberculosis by injections of immunized blood serum The antitoxic and bactericidal properties of the serum of horses treated with Koch's new tuberculin A further report on the use of anti-phthisic serum T.R. (Fisch) in tuberculosis Malignant lymphomas in transplantation patients Effect of cytomegalovirus prophylaxis with immunoglobulin or with antiviral drugs on post-transplant non-Hodgkin lymphoma: a multicentre retrospective analysis Pharmacokinetics of viral antibodies after administration of intravenous immunoglobulin in patients with chronic lymphocytic leukaemia or multiple myeloma Passive immunization with the anti-HIV-1 human monoclonal antibody (hMAb) 4E10 and the hMAb combination 4E10/2F5/2G12 Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies Adjunctive passive immunotherapy in human immunodeficiency virus type 1-infected individuals treated with antiviral therapy during acute and early infection Antibodies in HIV-1 vaccine development and therapy Structural insights on the role of antibodies in HIV-1 vaccine and therapy Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117 Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter-and intracontinental transmission events Recurrent challenges for clinicians: emergence of methicillin-resistant Staphylococcus aureus, vancomycin resistance, and current treatment options Current and future treatment options for infections caused by multidrugresistant gram-negative pathogens A novel investigational Fc-modified humanized monoclonal antibody, motavizumab-YTE, has an extended half-life in healthy adults Monoclonal antibody therapies against anthrax Raxibacumab for the treatment of inhalational anthrax The serum treatment of anthrax septicaemia The local and general serum treatment of cutaneous anthrax Protection against botulinum toxins provided by passive immunization with botulinum human immune globulin: evaluation using an inhalation model Botulinum neurotoxin neutralizing activity of immune globulin (IG) purified from clinical volunteers vaccinated with recombinant botulinum vaccine (rBV A/B) Antibody protection against botulinum neurotoxin intoxication in mice Equine antitoxin use and other factors that predict outcome in type A foodborne botulism Human botulism immune globulin for the treatment of infant botulism Early antitoxin treatment in wound botulism results in better outcome Infant botulism: a 30-year experience spanning the introduction of botulism immune globulin intravenous in the intensive care unit at Childrens Hospital Los Angeles Identification of a human monoclonal antibody to replace equine diphtheria antitoxin for treatment of diphtheria intoxication The therapeutic effect of homologous and heterologous antitoxins in experimental diphtheria and tetanus Importance of intravenous injection of diphtheria antiserum The recent epidemic of diphtheria in the Johns Hopkins hospital and medical school: General procedures adopted Use of diphtheria antitoxin in the treatment and prevention of diphtheria Diphtheritic polyneuropathy: a clinical study and comparison with Guillain-Barre syndrome Mice are actively immunized after passive monoclonal antibody prophylaxis and ricin toxin challenge Conformation-dependent highaffinity potent ricin-neutralizing monoclonal antibodies Characteristics of toxin-neutralization by anti-tetanus human monoclonal antibodies directed against the three functional domains Although neutralization escape mutants are a valid concern when using monoclonal antibody therapy, 38,39 this has not yet been a major problem during clinical use of palivizumab for respiratory syncytial virus (RSV). keywords: antibodies; antibody; clinical; days; disease; human; immune; immunity; immunization; immunoglobulin; immunotherapy; infection; mice; monoclonal; monoclonal antibodies; passive; patients; protection; serum; specific; study; therapy; treatment; use; vaccine; virus cache: cord-021770-zn7na974.txt plain text: cord-021770-zn7na974.txt item: #48 of 171 id: cord-022237-qxya4cs3 author: Bryant, Everett title: Biology and Diseases of Birds date: 2013-11-17 words: 13401 flesch: 58 summary: Chickens, turkeys, and other birds require the six major nu trients: carbohydrates for energy, fats for energy and essential fatty acids, protein for meat and egg production, minerals for bones and shells, vitamins for chemical catalysts, and water. Poultry and other birds are easily startled. keywords: age; birds; chickens; chicks; deficiency; diagnosis; disease; egg; epizootiology; etiology; feed; findings; lesions; mortality; necropsy; prevention; research; signs; transmission; treatment; turkeys; virus; vitamin; weeks cache: cord-022237-qxya4cs3.txt plain text: cord-022237-qxya4cs3.txt item: #49 of 171 id: cord-022292-msz4au4b author: Gershan, William M. title: Cough date: 2009-05-15 words: 13127 flesch: 45 summary: False-negative results of sweat tests can be seen in CF children presenting with edema or hypoproteinemia and in samples from children with an inadequate sweat rate. Similarly, pansinusitis is nearly universal among CF patients but is quite uncommon in other children. keywords: airway; aspiration; asthma; blood; bronchoscopy; cases; cause; chest; child; children; cough; diagnosis; disease; infants; infection; lung; patients; pneumonia; pulmonary; table; treatment cache: cord-022292-msz4au4b.txt plain text: cord-022292-msz4au4b.txt item: #50 of 171 id: cord-022404-cz3ruqxx author: Scott, Danny W. title: Dermatoses of Pet Rodents, Rabbits, and Ferrets date: 2009-05-15 words: 15524 flesch: 47 summary: 11, 17 Not surprisingly, S. aureus is a common opportunist and cause of skin infections in these species. Bacterial skin infections are uncommon in the ferret and are usually caused by S. aureus or Streptococcus spp. keywords: alopecia; animals; areas; deficiency; dermatitis; diagnosis; disease; erythema; ferrets; fig; gland; guinea; hair; head; infection; ivermectin; lesions; mice; mites; neck; pigs; pruritus; rabbits; rats; skin; tail; treatment cache: cord-022404-cz3ruqxx.txt plain text: cord-022404-cz3ruqxx.txt item: #51 of 171 id: cord-022448-ungitgh9 author: Sergueef, Nicette title: Clinical Conditions date: 2009-05-15 words: 77360 flesch: 48 summary: The male-to-female ratio for affected children is 2.5 : 1. 32, 33 Clubfoot deformity presents with different components: hindfoot equinus (inability to dorsifl ex), hindfoot varus and metatarsus adductus. 17 Pharyngeal collapse is involved and it is proposed that airway muscle dysfunction 19 or anatomic alterations predispose to that collapse. keywords: age; airway; area; associated; asthma; base; birth; body; bone; breathing; cavity; cervical; child; children; cranial; development; dysfunction; fi bers; fi rst; growth; head; infants; inferior; infl; lacrimal; lateral; life; mandible; middle; months; motion; mouth; muscles; nasal; nerve; palate; pattern; pharynx; portion; position; posterior; present; process; refl; relationship; respiratory; result; rotation; scoliosis; sinuses; sphenoid; spine; structures; sucking; superior; surface; swallowing; system; teeth; thoracic; tongue; treatment; years cache: cord-022448-ungitgh9.txt plain text: cord-022448-ungitgh9.txt item: #52 of 171 id: cord-022467-j2trahab author: Loo, May title: Select Populations: Children date: 2009-05-15 words: 19091 flesch: 37 summary: Relationship between breast-feeding duration and acute respiratory infections in infants Cognitive training in ADHD children: less to it than meets the eye Hyperactive children treated with stimulants: is cognitive training a useful adjunct? Efficacy and safety of a fixed-combination homeopathic therapy for sinusitis Clinical assessment of acupuncture in asthma therapy: discussion paper Committee on Drugs: Guidelines for the ethical conduct of studies to evaluate drugs in pediatric populations Committee on Children with Disabilities: Counseling families who choose complementary and alternative medicine for their child with chronic illness or disability Measles-mumps-rubella immunisation, autism, and inflammatory bowel disease: update Evaluation of massage with essential oils on childhood atopic eczema Respiratory syncytial virus vaccines for otitis media The use of alternative therapies by children with asthma: a brief report Use of complementary and alternative medicine in the treatment of asthma Use of complementary treatment by those hospitalised with acute illness Some nontraditional (unconventional and/or innovative) psychosocial treatments for children and adolescents: critique and proposed screening principles Hypnotherapy in the treatment of bronchial asthma International study of asthma and allergies in childhood (ISAAC): rationale and methods Asthma mortality and hospitalization among children and young adults: United States Cranio-sacral therapy and the treatment of common childhood conditions A comparison of active and simulated chiropractic manipulation as adjunctive treatment for childhood asthma Hypnosis and self-hypnosis in the management of nocturnal enuresis: a comparative study with imipramine therapy Spirituality, religion, and pediatrics: intersecting worlds of healing Acupuncture and micro-massage in the treatment of idiopathic nocturnal enuresis Treatment of incontinent boys with non-obstructive disease Academic medicine and complementary medicine differ from each other in reasoning and evaluation but not in goals Alternative and controversial treatments for attention-deficit/hyperactivity disorder Parent acceptability and feasibility of ADHD interventions: assessment, correlates, and predictive validity Management of acute and chronic otitis media in pediatric practice Evaluation of rhesus rotavirus monovalent and tetravalent reassortant vaccines in U.S. children Traditional acupuncture increases the content of beta-endorphin in immune cells and influences mitogen induced proliferation A double-blind placebo-controlled study of desipramine in the treatment of ADD. I. General trends and demographic groups Relationship of infant feeding to recurrent wheezing at age 6 years Current treatment of allergic rhinitis and sinusitis 302 cases of enuresis treated with acupuncture Treatment of acne with ear acupuncture-a clinical observation of 80 cases 14 cases of child bronchial asthma treated by auricular plaster and meridian instrument Acupuncture of guanyuan (Ren 4) and Baihui (Du 20) in the treatment of 500 cases of enuresis Effect of acupuncture on bronchial asthma Acupuncture treatment of chronic rhinitis in 75 cases Immediate antiasthmatic effect of acupuncture in 192 cases of bronchial asthma Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases Clinical and experimental study on yifei jianshen mixture in preventing and treating infantile repetitive respiratory infection Clinical investigation on massage for prevention and treatment of recurrent respiratory tract infection in children Pneumococcal conjugate vaccine for young children Prevention of asthma morbidity: recent advances keywords: acupuncture; acupuncture treatment; acute; age; alternative; asthma; breast; cam; childhood; children; chiropractic; chronic; diarrhea; disease; efficacy; enuresis; group; homeopathic; infants; medicine; months; otitis; patients; pediatric; studies; study; symptoms; therapy; treatment; trial; use; years cache: cord-022467-j2trahab.txt plain text: cord-022467-j2trahab.txt item: #53 of 171 id: cord-022520-ebj51v9o author: Marini, Robert P. title: Biology and Diseases of Ferrets date: 2007-09-02 words: 19517 flesch: 43 summary: Paper presented at the 90th Meeting of the American Veterinary Medical Association Salmonella infections in mink and ferrets The experimental transmission of a virus causing hypergammagloblinemia in mink: sources and modes in infection Meningeal cryptococcosis and congestive cardiomyopathy in a ferret The Biomedical Use of Ferrets in Research The Universities Federation for Animal Welfare Handbook on the Care and Management of Laboratory Animals Endocrine factors in hematological changes seen in dogs and ferrets given estrogens Cryptosporidiosis in the dog and cat Dematologic diseases Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery A Practitioner's Guide to Rabbits and Ferrets Recurrent Mycobacterium bovis infection following a ferret bite Cell mediated immunity in ferrets: delayed dermal hypersensitivity, lymphocyte transformation, and macrophage migration inhibitory factor production Experimental transmission of Aleutian disease with urine Enteric coccidial infections Heartworm infections Treatment of proliferative colitis in ferrets Current Veterinary Therapy 11 Haematological and serum chemistry profiles of ferrets (Mustela putorius furo) Biology and Diseases of the Ferret Cutaneous lymphoma in a ferret (Mustela putoriusfuro) The pathogenesis, pathology, and diagnosis of the disease in experimentally infected ferrets The Clinical Chemistry of Laboratory Animals Derivation of gnotobiotic ferrets: perinatal diet and hand-rearing requirements Lack of detectable blood groups in domestic ferrets: implications for transfusion Distribution of technetium 99m-labeled red blood cells during isoflurane anesthesia in ferrets Ranitidine-bismuth citrate and clarithromycin, alone or in combination, for eradication of Helicobacter mustelae infection in ferrets The effect of isoflurane on hematologic variables in ferrets The Biomedical Use of Ferrets in Research Congenital malformations and variations in reproductive performance in the ferret: effects of maternal age, color, and parity Dirofilariasis in a ferret Dirofilariasis in a ferret Use of the ferret in cardiovascular research Current Therapy in Theriogenology Soft tissue surgery Demodiciasis in ferrets (Mustela putorius furo) keywords: age; animals; associated; cases; cause; cell; chronic; control; days; diagnosis; diarrhea; disease; estrus; et al; ferrets; findings; fox; fox et; gastric; helicobacter; infection; jills; kits; lesions; mink; mustelae; necropsy; research; signs; skin; species; transmission; treatment; use; virus; weeks; weight cache: cord-022520-ebj51v9o.txt plain text: cord-022520-ebj51v9o.txt item: #54 of 171 id: cord-022526-j9kg00qf author: Jones, Samuel L. title: Disorders of the Gastrointestinal System date: 2009-05-18 words: 108877 flesch: 36 summary: Abdominal radiographs are reserved for smaller horses and ponies. In addition, one may detect mineral opacity within the colon on abdominal radiographs, particularly in foals, ponies, and small horses. keywords: absorption; acid; activity; acute; addition; administration; adult horses; bacteria; blood; body; bowel; cases; cause; cells; chronic; colic; colitis; colon; colonic; concentration; damage; diagnosis; diarrhea; disease; distention; effects; endothelial; endotoxemia; endotoxin; epithelium; equine; esophageal; esophagus; examination; factors; flow; fluid; foals; gastric; gastrointestinal; horses; hours; human; ileus; impaction; increase; infection; inflammation; inflammatory; injury; intestine; ischemia; lesions; lipopolysaccharide; loss; mediators; motility; mucosal; neutrophils; normal; obstruction; pain; patients; peritoneal; peritonitis; plasma; production; products; protein; proximal; rectal; release; response; result; role; salmonella; secretion; serum; signs; specific; squamous; study; surgery; therapy; tissue; tract; treatment; ulceration; vascular; wall cache: cord-022526-j9kg00qf.txt plain text: cord-022526-j9kg00qf.txt item: #55 of 171 id: cord-022555-a7ie82fs author: None title: Digestive System, Liver, and Abdominal Cavity date: 2011-12-05 words: 66503 flesch: 46 summary: The worm is transmitted to other cats that ingest the vomitus of an infected cat. Other cats should not be allowed to ingest infected vomit. keywords: acute; anorexia; bile; biopsy; blood; bodies; body; bowel; cases; cats; cause; cell; chronic; days; diagnosis; diarrhea; disease; dogs; esophageal; esophagus; examination; fecal; feces; feline; figure; findings; fluid; food; gastric; gastrointestinal; hepatic; hours; humans; infection; inflammation; inflammatory; lipidosis; liver; liver disease; loss; lymphoma; neoplasia; obstruction; pancreatic; pancreatitis; parasite; present; result; samples; serum; signs; specific; study; therapy; time; tissue; tract; treatment; vomiting; weeks; weight cache: cord-022555-a7ie82fs.txt plain text: cord-022555-a7ie82fs.txt item: #56 of 171 id: cord-022582-2e9i3m4b author: Potsic, William P. title: Otolaryngologic Disorders date: 2012-03-21 words: 16061 flesch: 47 summary: Children who are born deaf and are younger than the age of 3 years, as well as children who have already developed communication skills, language, and speech before losing their hearing, derive the greatest benefit from cochlear implants. The sound has to traverse the ear canal, tympanic membrane, and middle ear. keywords: acute; airway; bone; canal; cases; children; diagnosis; ear; hearing; infection; larynx; loss; mass; membrane; middle; nasal; neck; nerve; nose; obstruction; patients; posterior; symptoms; tissue; treatment; tube cache: cord-022582-2e9i3m4b.txt plain text: cord-022582-2e9i3m4b.txt item: #57 of 171 id: cord-022650-phsr10jp author: None title: Abstracts TPS date: 2018-08-14 words: 119916 flesch: 51 summary: Method: Postal questionnaires were distributed to an unselected group of asthma patients (n = 190). NHR was reported in 71% of asthma patients and 22% in non-asthmatic controls (P < 0.0001), with changes in temperature being the most important inducer of nasal symptoms (74% of asthmatics), followed by strong odours (62%) and cigarette smoke (61%). keywords: adults; age; aim; allergen; allergies; allergy; analysis; anaphylaxis; angioedema; anti; ara; asthma; asthma control; asthma patients; asthma symptoms; asthmatic; atopic; background; blood; case; cells; challenge; children; chronic; clinic; concentration; conclusion; control; control group; correlation; cross; data; days; dermatitis; diagnosis; differences; disease; dose; drug; dust; effect; efficacy; egg; episodes; exposure; extracts; factors; food; food allergy; grass; group; hae; high; history; hospital; hours; house; ige; ige levels; igg; immunotherapy; improvement; increase; levels; life; low; male; mean; median; medical; medication; method; milk; minutes; mite; months; nasal; non; number; p 1; p =; patients; peanut; period; pollen; pollen allergy; population; positive; present; prevalence; prick; protein; questionnaire; rate; reaction; reactivity; reduction; report; respiratory; response; results; rhinitis; rhinitis patients; risk; scit; score; sensitization; serum; severity; sige; skin; skin prick; slit; specific; spt; studies; study; subjects; symptoms; syndrome; test; testing; time; total; treatment; type; urticaria; use; weeks; years cache: cord-022650-phsr10jp.txt plain text: cord-022650-phsr10jp.txt item: #58 of 171 id: cord-022653-qa1uph35 author: None title: Poster Discussion Session PDS date: 2017-08-30 words: 58403 flesch: 49 summary: Out of all maxillary sinuses (n=72) from study patients, 62 (86.11%) were opacified, and only these sinuses were included in further analyses. We studied three groups of subjects: peach allergic patients who received Prup3-enriched-SLIT for 1 year, peach allergic patients non treated, and healthy controls who tolerated peach. keywords: age; aim; allergen; allergic; allergy; analysis; anaphylaxis; anti; associated; asthma; asthma patients; atopic; blood; cases; cells; changes; children; conclusions; control; correlation; data; diagnosis; differences; disease; dose; drug; effect; exposure; expression; food; food allergy; group; hdm; healthy; history; ige; ige levels; immune; immunotherapy; increase; inflammation; introduction; levels; low; mean; methods; mice; milk; months; nasal; non; number; objectives; patients; period; pollen; production; protein; reactions; reactivity; response; results; rhinitis; risk; samples; score; sensitization; serum; skin; slit; specific; studies; study; subjects; symptoms; test; therapy; time; total; treatment; use; years cache: cord-022653-qa1uph35.txt plain text: cord-022653-qa1uph35.txt item: #59 of 171 id: cord-022940-atbjwpo5 author: None title: Poster Sessions date: 2016-09-07 words: 241687 flesch: 44 summary: Among used cancer cell lines, ERICD was highly expressed and ARID3A had lower expression in U-2OS (osteosarcoma), A-172 (glioblastoma) and A549 (lung cancer). Clear cell renal cell cancer (ccRCC) with metastases has pour prognosis: 5-year survival is about 9%. keywords: a549 cells; acid; activation; activities; activity; activity levels; acute; addition; administration; affinity; agents; aim; albumin; allele; alterations; alternative; amino; analysis; analysis results; animals; ankara; anti; antibodies; antibody; anticancer; antioxidant; apoptosis; applications; approach; assay; association; bacteria; beta; binding; biology; blood; body; bone; brain; breast cancer; cancer cells; cancer group; cancer patients; cancer stem; cancer treatment; cancers; cause; cell cycle; cell death; cell growth; cell lines; cell proliferation; cell survival; cell viability; changes; characterization; chemical; cholesterol; chronic; clinical; coli; colorectal; combination; comparison; complex; complexes; compounds; concentrations; conclusion; conditions; content; control cells; control group; control study; controls; correlation; culture; curcumin; current; cytotoxic; damage; data; day; days; decrease; department; detection; determination; development; diabetes; differences; differentiation; discussion; disease; dna; domain; dose; drug; effects; elevated; elisa; energy; enzyme; enzyme activity; ethanol; experimental; expression analysis; expression levels; expressions; extract; factor; faculty; family; fat; findings; flow; fluorescence; fold; food; formation; free; function; gene expression; genes; genetic; genome; genotype; glucose; glutathione; group; growth; gsh; health; hours; human; immune; increase; inflammation; inflammatory; inhibition; inhibitors; injury; institute; insulin; interaction; intracellular; introduction; invasion; investigation; ischemia; kinase; laboratory; lead; levels; light; like; lipid; liver; low; lung; male; manner; markers; mass; materials; matrix; mcf-7; mda; mda levels; mean; mechanisms; medical; medicine; medium; membrane; metabolism; methods; methylation; mice; microscopy; migration; mirnas; mitochondrial; model; modified; molecular; molecules; mrna; muscle; mutant; mutations; n =; nanoparticles; negative; non; normal; novel; number; obese; obesity; oil; order; oxidative; oxygen; p =; p-02.08.5; parameters; pathway; patients; pcr; peptide; phase; plant; plasma; play; point; polymorphisms; population; potential; presence; present; process; processes; production; products; profile; progression; promoter; properties; prostate; prostate cancer; protective; protein; protein expression; protein levels; purpose; radical; range; rate; rats; reaction; receptor; recombinant; region; regulation; related; relationship; research; resistance; response; results; risk; role; samples; science; scientific; screening; sequence; serum; serum levels; signaling; site; size; sod; species; specific; stability; stage; status; stem cells; strain; stress; structure; studies; study; study group; subjects; surface; survival; synthesis; system; target; technique; temperature; test; tested; therapeutic; therapy; time; tissue; tnf; total; transcription; treatment; treatment group; tumor; tumor cells; turkey; type; university; use; values; vitamin; vitro; water; weight; western; wild; women; work; years cache: cord-022940-atbjwpo5.txt plain text: cord-022940-atbjwpo5.txt item: #60 of 171 id: cord-023095-4dannjjm author: None title: Research Abstract Program of the 2011 ACVIM Forum Denver, Colorado, June 15–18, 2011 date: 2011-05-03 words: 134382 flesch: 49 summary: Mminimum HR, mean HR and the HRV variables (7 and 10) differing between dog groups, also consistently decreased with increasing MR, LA/Ao and the proximal isovelocity surface area in CKCS. The apparently normal levels of hexosaminidase A activity in affected dog samples may be a result of b subunit overexpression. keywords: abnormalities; acid; acth; activity; administration; adult; age; aim; analysis; animals; assay; association; available; baseline; blood; blood samples; body; breed dogs; breeds; canine; cardiac; cases; cats; cell; changes; chf; chronic; clinical; cobalamin; compare; concentrations; control dogs; controls; correlation; cortisol; creatinine; data; days; decrease; detection; diagnosis; diet; difference; disease; dna; dogs; dose; drug; duration; effects; elisa; equine; evidence; examination; expression; failure; fecal; feline; findings; foals; following; food; function; gastrointestinal; gene; glucose; group; heart; horses; hours; human; increase; infection; insulin; isolates; levels; mean; median; medical; minutes; model; months; negative; non; number; observed; outcome; p o; parameters; patients; pcr; period; plasma; platelet; post; potential; presence; present; prevalence; protein; pulmonary; purpose; range; rate; reference; resistance; response; results; risk; role; samples; serum; serum concentrations; serum samples; severity; significance; signs; species; specific; spinal; spp; standard; studies; study; survival; test; therapy; time; tissue; total; treatment; type; urinary; urine; uroliths; use; values; veterinary; weeks; weight; years cache: cord-023095-4dannjjm.txt plain text: cord-023095-4dannjjm.txt item: #61 of 171 id: cord-023165-f6o6owg3 author: NAVARRE, CHRISTINE B. title: Diseases of the Gastrointestinal System date: 2009-05-21 words: 24580 flesch: 53 summary: Unlike in other small animals, contrast techniques are not practical for characterizing small intestinal problems in sheep and goats because the rumen dilutes and slows passage of the contrast media. Using EDTA tubes made for small animals or shaking excess EDTA out of large tubes resolves this problem. keywords: animals; bloat; cases; cattle; cause; chronic; clinician; condition; control; days; diagnosis; diarrhea; disease; feces; feed; fluid; goats; infection; kids; lambs; liver; parasites; prevention; resistance; rumen; ruminants; sheep; signs; suture; treatment cache: cord-023165-f6o6owg3.txt plain text: cord-023165-f6o6owg3.txt item: #62 of 171 id: cord-023168-cd7adns8 author: Thachil, Jecko title: Haematological Diseases in the Tropics date: 2013-10-21 words: 30246 flesch: 37 summary: WHD/3 Information sheet for clinicians Development and evaluation of a new paediatric blood transfusion protocol for Africa Electrocardiographic ST-segment changes during acute, severe isovolemic hemodilution in humans Use of clinical judgement to guide administration of blood transfusions in Malawi Giving tranexamic acid to reduce surgical bleeding in sub-Saharan Africa: an economic evaluation Autologous transfusion techniques: a systematic review of their efficacy Intraoperative autologous blood management Artificial O2 carriers: status in 2005 Red blood cell transfusions in acute paediatrics Survival and haematological recovery of children with severe malaria transfused in accordance to WHO guidelines in Kilifi Intermittent preventive therapy for malaria with monthly artemether-lumefantrine for the post-discharge management of severe anaemia in children aged 4-59 months in southern Malawi: a multicentre, randomised, placebocontrolled trial Bacterial contamination of pediatric whole blood transfusions in a Kenyan hospital Bacterial contamination of blood and blood components in three major blood transfusion centres in Accra, Ghana Access the complete references online at www.expertconsult.com Causes and outcomes of the acute chest syndrome in sickle cell disease The acute chest syndrome in sickle cell disease: incidence and risk factors Acute chest syndrome in sickle-cell disease Bronchoalveolar lavage in adult sickle cell patients with acute chest syndrome: value for diagnostic assessment of fat embolism Secretory phospholipase A(2) predicts impending acute chest syndrome in sickle cell disease Serum C-reactive protein parallels secretory phospholipase A2 in sickle cell disease patients with vasoocclusive crisis or acute chest syndrome Cerebrovascular accidents in sickle cell disease: rates and risk factors Pathophysiology and treatment of stroke in sicklecell disease: Present and future Lesion burden and cognitive morbidity in children with sickle cell disease Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography Silent infarction as a risk factor for overt stroke in children with sickle cell anemia: A report from the Cooperative Study of Sickle Cell Disease Nocturnal hypoxaemia and central-nervoussystem events in sickle-cell disease Natural history of blood pressure in sickle cell disease: Risks for stroke and death associated with relative hypertension in sickle cell anemia Prophylaxis with oral penicillin in children with sickle cell anemia. keywords: acute; anaemia; bleeding; blood; blood transfusion; bone; cause; cell; cell disease; children; chronic; complications; countries; deficiency; diagnosis; disease; factor; folate; g6pd; haemoglobin; haemolysis; hiv; individuals; infections; iron; iron deficiency; levels; lymphoma; major; malaria; management; marrow; patients; platelet; prevalence; risk; scd; syndrome; thalassaemia; therapy; thrombocytopenia; transfusion; treatment; vitamin; years cache: cord-023168-cd7adns8.txt plain text: cord-023168-cd7adns8.txt item: #63 of 171 id: cord-023528-z9rc0ubj author: Wilkins, Pamela A. title: Disorders of Foals date: 2009-05-18 words: 42606 flesch: 40 summary: A syndrome of bronchointerstitial pneumonia and acute respiratory distress has been described in older foals and appears to be a distinct entity from acute respiratory distress syndrome in neonatal foals in association with sepsis. One can use these measurements and the ultrasonographic appearance of the internal umbilical structures from clinically normal foals as references to diagnose abnormalities of the umbilical structures in neonatal foals. keywords: abnormalities; acute; administration; age; author; birth; blood; care; cases; cell; concentration; days; deformities; diagnosis; diarrhea; disease; effects; equine; failure; fetal; fetus; fluid; foals; function; gastric; horses; hours; human; hypoxia; infants; infection; injury; intravenous; joint; limb; mares; neonatal; neonate; newborn; oxygen; patients; pneumonia; rate; renal; result; risk; sepsis; signs; specific; therapy; treatment; use; ventilation cache: cord-023528-z9rc0ubj.txt plain text: cord-023528-z9rc0ubj.txt item: #64 of 171 id: cord-024893-pd67o7l8 author: Li, Lanjuan title: Translation: Expert Consensus on the Application of Artificial Liver Blood Purification System in the Treatment of Severe and Critical COVID-19: National Clinical Research Center for Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases date: 2020-04-17 words: 1338 flesch: 26 summary: Led by Academician Lanjuan Li, based on the experience of treating patients across the country, integrating the opinions of experts from all over the country, the center summarized and formulated the consensus including the basic principles, treatment indications, relative contraindications, mode selection, monitoring indicators, and efficacy evaluation of artificial liver, which provides reference for treatment of severe COVID-19 patients. 10 Patients should receive ALSS treatment if they meet criteria (1) & (2), or only (3). keywords: covid-19; patients; plasma; treatment cache: cord-024893-pd67o7l8.txt plain text: cord-024893-pd67o7l8.txt item: #65 of 171 id: cord-026031-hnf5vayd author: Ford, Richard B. title: Emergency Care date: 2009-05-21 words: 112481 flesch: 42 summary: animal patients. The normal CVP for small animal patients is 0 to 5 cm H 2 O. Values less than zero are associated with absolute or relative hypovolemia. keywords: abnormalities; acute; administer; administration; airway; animal; bandage; blood; blood pressure; body; cardiac; care; cases; catheter; cats; cause; charcoal; control; crystalloid; damage; days; decrease; diagnosis; disease; dogs; dose; drugs; dysrhythmias; edema; effects; effusion; emergency; emesis; examination; exposure; failure; fluid; following; function; gastrointestinal; heart; hemorrhage; hours; infection; ingestion; injury; intravenous; kg iv; kg po; lavage; loss; management; minutes; monitor; needle; normal; obstruction; occurs; oxygen; pain; patient; perform; perfusion; place; plasma; presence; present; pressure; pulmonary; radiographs; rate; renal; result; risk; saline; secondary; seizures; serum; shock; signs; skin; sodium; solution; supplemental; therapy; thoracic; time; tissue; toxicity; trauma; treatment; tube; urine; volume; vomiting; water; wound cache: cord-026031-hnf5vayd.txt plain text: cord-026031-hnf5vayd.txt item: #66 of 171 id: cord-027860-s97hdhh6 author: Zeimet, Anthony title: Infectious Diseases date: 2020-06-22 words: 28951 flesch: 42 summary: Management of such patients should be coordinated with an infectious diseases specialist, who also should manage drug-resistant TB treatment. Single positive blood culture for Coxiella burnetii or anti-phase 1 IgG antibody titer >1:800 Echocardiogram positive for IE (TEE recommended for patients with prosthetic valves, rated at least possible IE by clinical criteria, or complicated IE [paravalvular abscess]; TTE as first test in other patients) defined as follows: oscillating intracardiac mass on valve or supporting structures, in the path of regurgitant jets, or on implanted material in the absence of an alternative anatomic explanation; or abscess; or new partial dehiscence of prosthetic valve; new valvular regurgitation (worsening or changing or preexisting murmur not sufficient) Predisposition, predisposing heart condition, or IDU Fever, temperature >38° C Vascular phenomena, major arterial emboli, septic pulmonary infarcts, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhages, and Janeway's lesions Immunologic phenomena: glomerulonephritis, Osler's nodes, Roth's spots, and rheumatoid factor Microbiologic evidence: positive blood culture but does not meet a major criterion as noted above * or serological evidence of active infection with organism consistent with IE Echocardiographic minor criteria eliminated Echocardiography should be performed in all patients with suspected infective endocarditis (Baddour et al., 2005) keywords: acute; adults; antibiotics; bacterial; bite; blood; cause; children; chronic; culture; daily; days; diagnosis; diarrhea; discharge; disease; endocarditis; fever; gram; hepatitis; infection; influenza; lesions; months; negative; pain; patients; present; risk; skin; sor; symptoms; testing; therapy; treatment; use; vaccine; virus; weeks; women; wounds cache: cord-027860-s97hdhh6.txt plain text: cord-027860-s97hdhh6.txt item: #67 of 171 id: cord-029150-e242o2ml author: Du, Jiang title: Expert consensus on the prevention and treatment of substance use and addictive behaviour-related disorders during the COVID-19 pandemic date: 2020-07-08 words: 4258 flesch: 28 summary: The treatment of comorbid physical and mental illnesses often requires the deployment of alternative addiction treatments. In addition, certain circumstances will make treatment of such patients difficult, including isolation management, fear of being infected when going out to take medication, conscious avoidance of treatment and complications of the medication process under pandemic conditions. keywords: addiction; covid-19; mental; pandemic; patients; problems; risk; substance; treatment; use cache: cord-029150-e242o2ml.txt plain text: cord-029150-e242o2ml.txt item: #68 of 171 id: cord-031978-l6nlrv9h author: Chauvenet, Alienor title: Panel sampling in health research date: 2020-09-16 words: 1435 flesch: 39 summary: First, to reach a sufficient number of participants in randomised clinical trials, international consortia should be established to enable recruitment within a reasonable timeframe. A target protocol describes the ideal, but unachievable randomised clinical trial. keywords: health; medication; treatment; trials cache: cord-031978-l6nlrv9h.txt plain text: cord-031978-l6nlrv9h.txt item: #69 of 171 id: cord-034340-3ksfpaf7 author: None title: Proceedings of the 26th European Paediatric Rheumatology Congress: part 2: Virtual. 23 - 26 September 2020 date: 2020-10-28 words: 35133 flesch: 46 summary: Results: Of the 35 metabolites measured, 23 were significantly lower in JIA patients before the Etanercept treatment compared to the healthy control group. Urine metabolite ratios reflecting CYP21 and 11β-HSD2 enzymatic activity indicate that these two enzyme activities were lower in JIA patients. keywords: activity; adalimumab; age; anti; antibodies; arthritis; cases; children; cohort; conclusion; criteria; data; diagnosis; disease; fever; group; high; inflammation; introduction; involvement; jia; jia patients; joint; juvenile; laboratory; levels; methods; months; mtx; negative; objectives; onset; pain; patients; pediatric; positive; present; pts; report; response; results; rheumatology; sjia; study; symptoms; syndrome; systemic; therapy; treatment; uveitis; years cache: cord-034340-3ksfpaf7.txt plain text: cord-034340-3ksfpaf7.txt item: #70 of 171 id: cord-102145-bi8jyz6r author: Wilson, Audrey E title: Spatial heterogeneity in resources alters selective dynamics in Drosophila melanogaster date: 2020-09-05 words: 5932 flesch: 33 summary: Across the six mutation types, there was no consistent overall pattern in purging rate between the NT, UCT, and SCT environmental treatments. We found that allele purging dynamics depended on spatial environment, however the patterns of purging rates between the environments differed across distinct deleterious mutations. keywords: environments; males; mating; mutant; mutations; purging; selection; treatment cache: cord-102145-bi8jyz6r.txt plain text: cord-102145-bi8jyz6r.txt item: #71 of 171 id: cord-104431-3rblzyry author: Hill, Andrew title: Minimum costs to manufacture new treatments for COVID-19 date: 2020-04-30 words: 5534 flesch: 54 summary: For consistency, we selected a single data source per country to be used for all searches of drug prices within that country, based on the organisation of data and perceived reliability. The minimum costs of drug production can be estimated by calculating the cost of active pharmaceutical ingredients (aPi), which is combined with costs of excipients, formulation, packaging and a profit margin, to estimate the price of 'final finished product' (FFP) -the drug ready for use. keywords: api; cost; countries; course; covid-19; day; drugs; list; prices; production; treatment; trials cache: cord-104431-3rblzyry.txt plain text: cord-104431-3rblzyry.txt item: #72 of 171 id: cord-193947-vcm3v0ix author: Pollmann, Michael title: Causal Inference for Spatial Treatments date: 2020-10-31 words: 27980 flesch: 42 summary: They have an attractive quasi-experimental interpretation and are valid by design if the choice of treatment location is as good as random within a set of plausible candidate locations. Instead, I recommend estimators that are formally valid under the quasi-experimental variation in treatment location sometimes used to informally justify the assumptions of the difference-in-differences approach. keywords: assumption; average; candidate locations; candidate treatment; control; data; distance; grocery; individuals; number; outcomes; paper; region; ring; store; treatment assignment; treatment effects; treatment locations; treatments; variance; â � cache: cord-193947-vcm3v0ix.txt plain text: cord-193947-vcm3v0ix.txt item: #73 of 171 id: cord-252984-79jzkdu2 author: Bickman, Leonard title: Improving Mental Health Services: A 50-Year Journey from Randomized Experiments to Artificial Intelligence and Precision Mental Health date: 2020-07-26 words: 35544 flesch: 44 summary: Confidentiality and trust are key issues in mental health treatment. I was trained as a social psychologist and was a graduate student of Stanley Milgram (of the famous obedience experiments), so I was curious about the research on the relationship between technological virtual agents and humans beyond the context of mental health treatment. keywords: analysis; approach; authors; bickman; care; causal; children; clinical; clinicians; data; depression; effectiveness; et al; evidence; feedback; health; health services; human; interventions; issue; learning; machine; medicine; mental; meta; need; new; outcomes; paper; potential; precision; problems; psychiatry; rcts; research; review; services research; social; studies; study; system; therapy; time; treatment; use cache: cord-252984-79jzkdu2.txt plain text: cord-252984-79jzkdu2.txt item: #74 of 171 id: cord-255460-r5p5helx author: Aggarwal, Sadhna title: Drug repurposing for breast cancer therapy: Old weapon for new battle date: 2019-09-21 words: 7359 flesch: 38 summary: The widely used SERMs that have been repositioned as breast cancer drugs are tamoxifen (1977), toremifene (1997) and raloxifene (2007) . Drug companies that expand the repositioning in similar therapeutic areas, such as reusing ovarian cancer drug as breast cancer drug, had success rate of 67% in comparison to 33% success rate when explored in different area keywords: breast; breast cancer; cancer; combination; development; drug; effects; hormone; new; patients; phase; receptor; repositioning; repurposing; therapy; treatment; trial; women cache: cord-255460-r5p5helx.txt plain text: cord-255460-r5p5helx.txt item: #75 of 171 id: cord-255781-55zrmgxq author: Bergman, Scott J. title: Interferons as Therapeutic Agents for Infectious Diseases date: 2011-12-31 words: 6417 flesch: 37 summary: 39 Loss of viral DNA and antibody formation are successful outcomes associated with IFN treatment. 25, 38, 43 However, in 2009 several major studies were published associating a singlenucleotide polymorphism (SNP) just upstream from interleukin-28B gene (IL28B) with IFN response in patients with HCV genotype 1. keywords: chronic; effects; hcv; hepatitis; ifn; infection; interferon; patients; response; therapy; treatment; use; virus cache: cord-255781-55zrmgxq.txt plain text: cord-255781-55zrmgxq.txt item: #76 of 171 id: cord-261221-9qlndtuo author: Kim, Hwan Soo title: Efficacy of glucocorticoids for the treatment of macrolide refractory mycoplasma pneumonia in children: meta-analysis of randomized controlled trials date: 2019-12-18 words: 3360 flesch: 34 summary: Eval Anal Drug-Use Hosp China Clinical analysis of the effects of methylprednisolone on the treatment of refractory mycoplasma pneumoniae pneumonia in children To observe the curative effect of small dose of glucocorticoid combined with Pulmicort inhalation in the treatment of refractory mycoplasma pneumonia Hormone refractory mycoplasma pneumonia lavage cytokines Intravenous methylprednisolone combined with azithromycin in treatment of children with refractory mycoplasma pneumonia and influence on relevant laboratory parameters Clinical effect of methylprednisolone pluse therapy in treatment of refractory mycoplasma pneumoniae in children Clinical effect of methylprednisolone combined with azithromycin sequential therapy in treating children with mycoplasma pneumonia and the impact on serum levels CRP and sTREM-1 Clinical analysis of methylprednisolone in the treatment of children refractory mycoplasma pneumoniae pneumonia Analysis of the effect of combined use of methylprednisolone and azithromycin on refractory mycoplasma pneumonia in children Effect of small doses of methylprednisolone treatment of children with refractory mycoplasma Effects of methylprednisolone or immunoglobulin when added to standard treatment with intravenous azithromycin for refractory mycoplasma pneumoniae pneumonia in children Epidemiology and clinical features of mycoplasma pneumoniae infection in children Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial Mycoplasma pneumoniae and its role as a human pathogen Role of interleukin-18 and T-helper type 1 cytokines in the development of mycoplasma pneumoniae pneumonia in adults Cytoadherence-dependent induction of inflammatory responses by mycoplasma pneumoniae Comparison of the clinical manifestations of severe acute respiratory syndrome and mycoplasma pneumoniae pneumonia Macrolide-resistant mycoplasma pneumoniae: its role in respiratory infection Methylprednisolone pulse therapy for refractory mycoplasma pneumoniae pneumonia in children These variable treatment protocols are due to the lack of guidelines for glucocorticoids treatment in severe MRMP to date [7, 46] . keywords: children; glucocorticoids; mycoplasma; pneumonia; refractory; studies; treatment cache: cord-261221-9qlndtuo.txt plain text: cord-261221-9qlndtuo.txt item: #77 of 171 id: cord-261671-1pvg3apl author: Titov, Nickolai title: User characteristics and outcomes from a national digital mental health service: an observational study of registrants of the Australian MindSpot Clinic date: 2020-10-19 words: 6135 flesch: 44 summary: Review of the evidence from four countries Barriers to mental health treatment: results from the National Comorbidity Survey Replication Advantages and limitations of internetbased interventions for common mental disorders From research to practice: ten lessons in delivering digital mental health services Transparency about the outcomes of mental health services (IAPT approach): an analysis of public data The first 30 months of the MindSpot Clinic: evaluation of a national e-mental health service against project objectives Australian Government Department of Health and Ageing MindSpot Clinic: an accessible, efficient and effective online treatment service for anxiety and depression Rapid report: early demand, profiles and concerns of mental health users during the coronavirus (COVID-19) pandemic A comparison of Indigenous and non-Indigenous users of MindSpot: an Australian digital mental health service A comparison of the characteristics and treatment outcomes of migrant and Australian-born users of a national digital mental health service The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies Mental health triage policy Procedures for risk management and a review of crisis referrals from the MindSpot Clinic, a national service for the remote assessment and treatment of anxiety and depression Transdiagnostic versus disorder-specific and clinician-guided versus self-guided internet-delivered treatment for generalized anxiety disorder and comorbid disorders: a randomized controlled trial Disorder-specific versus transdiagnostic and clinician-guided versus self-guided treatment for major depressive disorder and comorbid anxiety disorders: a randomised controlled trial Internet-delivered treatment for older adults with anxiety and depression: implementation of the Wellbeing Plus Course in routine clinical care and comparison with research trial outcomes Internet-delivered treatment for young adults with anxiety and depression: evaluation in routine clinical care and comparison with research trial outcomes The PHQ-9: validity of a brief depression severity measure A brief measure for assessing generalised anxiety disorder: the GAD-7 Anxiety disorders in primary care: prevalence, impairment, comorbidity, and detection Short screening scales to monitor population prevalences and trends in non-specific psychological distress Primary mental health care minimum data set. Interest is growing in digital and telehealth delivery of mental health services, but data are scarce on outcomes in routine care. keywords: anxiety; assessment; care; clinic; data; health; mindspot; patients; people; services; symptoms; treatment cache: cord-261671-1pvg3apl.txt plain text: cord-261671-1pvg3apl.txt item: #78 of 171 id: cord-262115-kdeynhzq author: Opgenorth, Julie title: Colostrum supplementation with n-3 fatty acids alters plasma polyunsaturated fatty acids and inflammatory mediators in newborn calves date: 2020-10-09 words: 7524 flesch: 50 summary: The ALA significantly differed in concentration among CON and FF treatment calves during the first week of life (24, 46, 73, and 140 nM, respectively; P < 0.001) as well. The supplement for treatment calves was then added to 2.8 L of colostrum, but control calves did not receive any supplement. keywords: acid; calves; colostrum; concentrations; fish; flaxseed; n-3; oil; plasma; treatments cache: cord-262115-kdeynhzq.txt plain text: cord-262115-kdeynhzq.txt item: #79 of 171 id: cord-262339-e2ayh108 author: Bohner, Lauren title: 2019-nCoV: Measures Adopted at the Departments of Oral Surgery and Radiology during the Period of an Uncontrolled Transmission Increase date: 2020-06-08 words: 1674 flesch: 52 summary: Emergency treatments of infected patients should be performed, when possible, in an isolated dental office. When treating infected patients, the use of a special mask, FFP-2 or FFP-3, is strongly recommended [7] [8] [9] . keywords: measures; ncov; patients; use cache: cord-262339-e2ayh108.txt plain text: cord-262339-e2ayh108.txt item: #80 of 171 id: cord-262551-hxhlhb5m author: van der Gronde, Toon title: Toward a New Model of Understanding, Preventing, and Treating Adolescent Depression Focusing on Exhaustion and Stress date: 2020-05-06 words: 5761 flesch: 34 summary: Psychedelic drugs in the treatment of anxiety, depression and addiction Serotonergic hallucinogens in the treatment of anxiety and depression in patients suffering from a life-threatening disease: A systematic review Antidepressive, anxiolytic, and antiaddictive effects of ayahuasca, psilocybin and lysergic acid diethylamide (LSD): a systematic review of clinical trials published in the last 25 years Psilocybin for treatment-resistant depression: fMRImeasured brain mechanisms Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study Plasma brain derived neurotrophic factor (BDNF) and response to ketamine in treatment-resistant depression Antidepressant actions of ketamine: from molecular mechanisms to clinical practice Ketamine and nitrous oxide: The evolution of NMDA receptor antagonists as antidepressant agents Esketamine for treatment resistant depression: a trick of smoke and mirrors? Understanding, Preventing, and Treating Adolescent Depression Frontiers in Psychiatry | www Therapeutic effect of increased openness: Investigating mechanism of action in MDMA-assisted psychotherapy IL-6 and depression: A systematic review and meta-analysis of longitudinal studies Inflammatory biomarkers and depression Toward a revised evolutionary adaptationist analysis of depression: the social navigation hypothesis Cognitive bias modification for anxiety: current evidence and future directions From Hans Selye's discovery of biological stress to the identification of corticotropin-releasing factor signaling pathways: implication in stress-related functional bowel diseases What does the legacy of Hans Selye and Franz Alexander mean today? In later years, reduced adult neurogenesis and changes in structural and functional neuronal plasticity have been linked to the onset and treatment opportunities of major depression (10, 11) . keywords: adolescents; behavior; coping; depression; disorder; exhaustion; mood; patients; review; stress; symptoms; treatment cache: cord-262551-hxhlhb5m.txt plain text: cord-262551-hxhlhb5m.txt item: #81 of 171 id: cord-263189-5ukn2xbr author: Di Girolamo, Nicola title: Medical and Surgical Emergencies in Ferrets date: 2016-04-28 words: 4798 flesch: 36 summary: Vestibular syndrome due to a choroid plexus papilloma in a ferret Diagnostic exercise: ataxia and incoordination in ferrets Immune-mediated pure red cell aplasia in a domestic ferret Aplastic anemia associated with estrus in pet ferrets Bone marrow hypoplasia associated with estrus in ferrets Hyperadrenocorticism associated with adrenocortical tumor or nodular hyperplasia of the adrenal gland in ferrets: 50 cases (1987-1991) Signs of estrus in an ovariectomized ferret Spontaneous thecoma in a spayed pet ferret (Mustela putorius furo) with alopecia and swollen vulva Remission of estrus-associated anemia following ovariohysterectomy and multiple blood transfusions in a ferret Diseases of the genitourinary system Lack of detectable blood groups in domestic ferrets: implications for transfusion Transfusion medicine in exotic pets Assessment of a blood preservation protocol for use in ferrets before transfusion Correlation between age at neutering and age at onset of hyperadrenocorticism in ferrets Optimal dose of human chorionic gonadotropin for inducing ovulation in the ferret The use of a slow release GnRH-agonist implant in female ferrets in season for oestrus suppression Comparison of 4.7-mg deslorelin implants and surgery for the treatment of adrenocortical disease in ferrets Ultrasonographic visualization of the adrenal glands of healthy ferrets and ferrets with hyperadrenocorticism Toxicology of ferrets Copper toxicosis in sibling ferrets Veterinary toxicology: basic and clinical principles Ibuprofen ingestion in ferrets: 43 cases Rodenticides and avicides: anticoagulant rodenticides Coagulation values in normal ferrets (Mustela putorius furo) using selected methods and reagents Gastrointestinal foreign body in ferrets: 25 cases (1986-1990) key: cord-263189-5ukn2xbr authors: Di Girolamo, Nicola; Selleri, Paolo title: Medical and Surgical Emergencies in Ferrets date: 2016-04-28 journal: Vet Clin North Am Exot Anim Pract DOI: 10.1016/j.cvex.2016.01.006 sha: doc_id: 263189 cord_uid: 5ukn2xbr In the last few years, significant improvement in diagnosis and treatment of ferret emergencies has occurred. keywords: blood; cases; diagnosis; disease; disorders; ferrets; fig; furo; mustela; putorius; treatment cache: cord-263189-5ukn2xbr.txt plain text: cord-263189-5ukn2xbr.txt item: #82 of 171 id: cord-265848-afkeuwup author: None title: Chapter 2 Emergency Management of Poisoning date: 2007-12-31 words: 27431 flesch: 34 summary: small bowel obstruction secondary to amitriptyline overdose therapy Rectal ulcer with massive hemorrhage due to activated charcoal treatment in oral organophosphate poisoning Intestinal pseudo-obstruction following the use of enteral charcoal and sorbitol and mechanical ventilation with papaveretum sedation for theophylline poisoning Charcoal stercolith with intestinal perforation in a patient treated for amitriptyline ingestion Treatment with activated charcoal complicated by gastrointestinal obstruction requiring surgery Multiple doseactivated charcoal as a cause of acute appendicitis Small-bowel obstruction secondary to activated charcoal and adhesions Position statement: cathartics. In referred patients who have already been hospitalized elsewhere, ventricular arrhythmia may be due to hyperkalemia because renal failure may have ensued; in such patients, IV sodium bicarbonate, glucose/insulin, and, if necessary, calcium chloride administration may be warranted. keywords: acid; acute; administration; agents; blood; burns; calcium; case; charcoal; clearance; decontamination; dialysis; drug; effects; efficacy; elimination; extracorporeal; failure; gastrointestinal; glycol; hemodialysis; ingestion; intoxication; intubation; management; mdac; overdose; patient; peritoneal; poisoning; pressure; removal; skin; study; theophylline; therapy; toxicity; treatment; use; water cache: cord-265848-afkeuwup.txt plain text: cord-265848-afkeuwup.txt item: #83 of 171 id: cord-266147-s8rxzm0t author: Burnouf, Thierry title: Modern Plasma Fractionation date: 2007-03-28 words: 8837 flesch: 35 summary: An updated list of the major therapeutic applications of plasma protein products can be found elsewhere. Modern plasma product production technology remains largely based on the ethanol fractionation process, but much has evolved in the last few years to improve product purity, to enhance the recovery of immunoglobulin G, and to isolate new plasma proteins, such as α1-protease inhibitor, von Willebrand factor, and protein C. Because of the human origin of the starting material and the pooling of 10 000 to 50 000 donations required for industrial processing, the major risk associated to plasma products is the transmission of blood-borne infectious agents. keywords: blood; chromatography; factor; fractionation; fviii; heat; igg; inactivation; plasma; process; production; products; protein; removal; safety; steps; treatment; viruses cache: cord-266147-s8rxzm0t.txt plain text: cord-266147-s8rxzm0t.txt item: #84 of 171 id: cord-268168-yzvag38x author: Scolnick, Barbara title: Remission from Chronic Anorexia Nervosa With Ketogenic Diet and Ketamine: Case Report date: 2020-07-30 words: 4655 flesch: 48 summary: Ketones are produced in the liver whenever fat metabolism increases over carbohydrate metabolism; such as fasting, post-exercise, neonatal period, and KG diet, as well as during pathological states such as starvation or uncontrolled diabetes mellitus (9) . KG diets for AN have been roundly dismissed by eating disorder experts, and with the exception of an early study in 1998, ketamine has not been reported as effective in AN. keywords: anorexia; diet; infusions; ketamine; ketogenic; nervosa; patient; treatment; weight cache: cord-268168-yzvag38x.txt plain text: cord-268168-yzvag38x.txt item: #85 of 171 id: cord-269031-sz8ieltb author: Solé, G title: Guidance for the care of neuromuscular patients during the COVID-19 pandemic outbreak from the French Rare Health Care for Neuromuscular Diseases Network date: 2020-04-20 words: 5750 flesch: 33 summary: key: cord-269031-sz8ieltb authors: Solé, G; Salort-Campana, E; Pereon, Y; Stojkovic, T; Wahbi, K; Cintas, P; Adams, D; Laforet, P; Tiffreau, V; Desguerre, I; Pisella, LI; Molon, A; Attarian, S title: Guidance for the care of neuromuscular patients during the COVID-19 pandemic outbreak from the French Rare Health Care for Neuromuscular Diseases Network date: 2020-04-20 journal: Rev Neurol (Paris) DOI: 10.1016/j.neurol.2020.04.004 sha: doc_id: 269031 cord_uid: sz8ieltb Abstract In France, the epidemic phase of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in February 2020 and resulted in the implementation of emergency measures and a degradation in the organization of neuromuscular reference centers. The French Rare Health Care for Neuromuscular Diseases Network (FILNEMUS) also announced guidance in an attempt to homogenize the management of neuromuscular patients in this context to limit the contamination of extremely fragile patients while avoiding the loss of survival chance linked to the interruption of essential treatment or follow-up. keywords: care; context; covid-19; diseases; emergency; gravis; health; months; myasthenia; patients; risk; therapy; treatment cache: cord-269031-sz8ieltb.txt plain text: cord-269031-sz8ieltb.txt item: #86 of 171 id: cord-269776-hj1s3ipp author: Agostoni, Angelo title: Hereditary and acquired angioedema: Problems and progress: Proceedings of the third C1 esterase inhibitor deficiency workshop and beyond date: 2004-09-11 words: 50588 flesch: 41 summary: The plasma kallikrein-kinin system counterbalances the renin-angiotensin system The physiologic basis of assembly and activation of the plasma kallikrein/kinin system Mechanism of enhanced kinin release from high molecular weight kininogen by plasma kallikrein after its exposure to plasmin Detection of active kallikrein in induced blister fluids of hereditary angioedema patients Dose-dependent effects of postmenopausal estrogen and progestin on antithrombin III and factor XII Increased euglobulin fibrinolytic potential in women on oral contraceptives low in oestrogen-levels of extrinsic and intrinsic plasminogen activators, prekallikrein, factor XII, and C1-inactivator Molecular basis of estrogen regulation of Hageman factor XII gene expression Contact factors in plasma from women on oral contraception-significance of factor XI for the measured activity of factor XII Biochemical and molecular pharmacology of kinin receptors Transcription factor nuclear factor kappaB regulates the inducible expression of the human B1 receptor gene in inflammation Receptors for kinins: from classical pharmacology to molecular biology Mechanisms regulating the expression, self-maintenance, and signaling-function of the bradykinin B2 and B1 receptors Regulation of bradykinin B2-receptor expression by oestrogen Coexistence of hereditary angioedema and Turner's syndrome Hereditary angioedema precipitated by estrogen replacement therapy in a menopausal woman Recurrent episodes of skin angioedema and severe attacks of abdominal pain induced by oral contraceptives or hormone replacement therapy Recurrent angioedema: familial and oestrogen-induced Angioedema and oral contraception Recurrent angioedema associated with hypogonadism or anti-androgen therapy Estrogen induction and contact phase activation of human factor XII Enhanced expression of factor XII (Hageman factor) in isolated livers of estrogenand prolactin-treated rats The influence of estrogen and prolactin on Hageman factor (factor XII) titer in ovariectomized and hypophysectomized rats Differential regulation of kininogen gene expression by estrogen and progesterone in vivo The effect of oestrogen dose and progestogen type on haemostatic changes in women taking low dose oral contraceptives Effects of a very low-estrogen oral contraceptive on clotting factors, carbohydrate metabolism and plasma lipids and lipoproteins Contact activation factors in plasma from women using oral contraceptives-increased levels of factor XII, kinin-free high molecular weight kininogen and acetone-activated kallikrein Estrogen-associated thromboembolism Contact factor mediated fibrinolysis is increased by the combined oral contraceptive pill Prospective randomized study of effects of unopposed estrogen replacement therapy on markers of coagulation and inflammation in postmenopausal women Positive impact of hormone replacement therapy on the fibrinolytic system: a long-term randomized controlled study in healthy postmenopausal women Postmenopausal hormone replacement therapy increases coagulation activity and fibrinolysis Effect of long-term hormone replacement therapy on angiotensin-converting enzyme activity and bradykinin in postmenopausal women with essential hypertension and normotensive postmenopausal women Estrogen regulation of angiotensin-converting enzyme mRNA Sex hormones in hereditary angioneurotic oedema The complete drug reference Bethesda: American Society of Health-System Pharmacists DRUGDEXÒ system Hereditary angioedema and oral contraception Effects of methylamine and heparin on a rapid chromogenic assay of C1-esterase inhibitor in plasma Effect of time, temperature and additives on a functional assay of C1 inhibitor Effects of estrogen replacement therapy on the renin-angiotensin system in postmenopausal women Management and diagnostic guidelines for urticaria and angio-oedema Hereditary angioneurotic oedema in three families: symptomatic heterogeneity, complement analysis and therapeutic trials Hereditary angioneurotic oedema in Finland: clinical, immunological and genealogical studies Hereditary angioedema due to deficit of C1 esterase inhibitor Hereditary angioneurotic edema: a clinical survey C1-INH defect as an example of deficiency disease Hereditary angioedema: danazol therapy in a 5-year-old child Hereditary angioneurotic oedema: current management in pregnancy A multicentre evaluation of the diagnostic efficiency of serological investigations for C1 inhibitor deficiency Inherited and acquired deficiencies of C1 esterase inhibitor in humans C3 is activated in hereditary angioedema, and C1/C1-inhibitor complexes rise during physical stress in untreated patients Contact system in healthy term newborns: reference values in cord blood Application of a monoclonal antibody against a neoepitope on activated C4 in an ELISA for the quantification of complement activation via the classical pathway C1 inhibitor and diagnosis of hereditary angioedema in newborns Complement components in 100 newborns and their mothers determined by electroimmunoassay Angioedema: a review on the acquired, allergic or non-allergic, and the hereditary forms Serum complement levels in infancy: age related changes Influence of age and sex on serum complement components in children Development of the human coagulation system in the full-term infant Plasma protease inhibitors in premature infants: influence of gestational age, postnatal age, and health status Serum complement profiles in infants and children Misdiagnosis of hereditary angio-oedema type 1 and type 2 Acute consumption of C1 inhibitor in a patient with acquired C1-inhibitor deficiency syndrome Normal complement C4 values do not exclude hereditary angioedema Hereditary angioneurotic oedema Treatment of hereditary angioedema with a vapor-heated C1 inhibitor concentrate Replacement therapy in hereditary angioedema: successful treatment of acute episodes of angioedema with partly purified C1 inhibitor C1 INH concentrate in the therapy of hereditary angioedema C1-esterase inhibitor transfusions in patients with hereditary angioedema Replacement therapy in hereditary angioedema: successful treatment of two patients with fresh frozen plasma C1-inhibitor deficiency and angioedema Treatment of hereditary angioedema Letter: anaphylactic reaction to aprotinin DX-88 and HAE: a developmental perspective The synthetic Kunitz domain protein DX-88 to treat angioedema in patients with hereditary angioedema Role of kinins in seasonal allergic rhinitis: icatibant, a bradykinin B2 receptor antagonist, abolishes the hyperresponsiveness and nasal eosinophilia induced by antigen Efficacy and tolerability of Icatibant (Hoe 140) in patients with moderately severe chronic bronchial asthma Jerini announces positive phase II study results with Icatibant for the treatment of Hereditary Angioedema A phase I study of recombinant human C1-INH in asymptomatic patients with hereditary angioedema-HAE Pharming features clinical results of C1 inhibitor at investigator meeting [press release Treatment of hereditary angioedema with danazol: reversal of clinical and biochemical abnormalities Morphologic evaluation of the liver in hereditary angioedema patients on long-term treatment with androgen derivatives Side effects of long-term prophylaxis with attenuated androgens in hereditary angioedema: comparison of treated and untreated patients The long-term safety of danazol in women with hereditary angioedema Long-term treatment of hereditary angioedema with attenuated androgens: a survey of a 13-year experience Danazol therapy: an unusual aetiology of hepatocellular carcinoma Hepatocellular adenomas in patients taking danazol for hereditary angio-oedema Danazol-induced hepatocellular adenoma in patients with hereditary angio-oedema A case of hereditary angioneurotic oedema, successfully treated with epsilonaminocaproic acid: studies on C'1 esterase inhibitor, C'1 activation, plasminogen level and histamine metabolism Long-term prophylaxis with C1-inhibitor (C1 INH) concentrate in patients with recurrent angioedema caused by hereditary and acquired C1-inhibitor deficiency Pharmacokinetic parameters of C1-inhibitor concentrate in 40 patients with hereditary angio-oedema (HAE)-a prospective study Acute airway obstruction following tooth extraction in hereditary angioedema Oral manifestations and dental management of patients with hereditary angioedema Hereditary angioedema: report of case Prophylactic use of epsilon aminocaproic acid for oral surgery in a patient with hereditary angioneurotic edema Tranexamic acid: preoperative prophylactic therapy for patients with hereditary angioneurotic edema Intravenous tranexamic acid in the management of hereditary angio-oedema Potentially fatal hereditary angioedema: a review and case report The efficacy of short-term danazol prophylaxis in hereditary angioedema patients undergoing maxillofacial and dental procedures Successful off-pump coronary artery bypass graft surgery in a patient with hereditary angioedema Preoperative prophylaxis for C1 esterase-inhibitor deficiency in patients undergoing oral surgery: a report of three cases Hereditary angioedema: uncomplicated maxillofacial surgery using short-term C1 inhibitor replacement therapy C1-esterase inhibitor concentrate prevents upper airway obstruction in hereditary angio-oedema Acquired angioedema as the presenting feature of lymphoproliferative disorders of mature B-lymphocytes Spontaneous regression of acquired C1 esterase inhibitor deficiency associated with splenic marginal zone lymphoma presenting with recurrent angio-oedema Acquired angioedema associated with rectal carcinoma and its response to danazol therapy: acquired angioedema treated with danazol Activation of the contact system and fibrinolysis in autoimmune acquired angioedema: a rationale for prophylactic use of tranexamic acid Angioneurotic edema with acquired C1-inhibitor deficiency and autoantibody to C1-inhibitor: response to plasmapheresis and cytotoxic therapy Purity, activity, and virus safety of a pasteurized antithrombin concentrate A factor VIII concentrate, highly purified and heated in solution Virus-safe plasma proteins: elimination of viruses of risk by the manufacturing procedure Inactivation of hepatitis A virus by pasteurization and elimination of picornaviruses during manufacture of factor VIII concentrate Absence of anti-human immunodeficiency virus types 1 and 2 seroconversion after the treatment of hemophilia A or von Willebrand's disease with pasteurized factor VIII concentrate Absence of hepatitis after treatment with a pasteurized factor VIII concentrate in patients with hemophilia and no previous transfusions Effectiveness of alternative treatments for reducing potential viral contaminants from plasma-derived products Inactivation of parvovirus B19 during pasteurization of human serum albumin A novel coronavirus associated with severe acute respiratory syndrome Virus safety of pasteurized clotting factor concentrates: an eleven year follow up Hepatitis C and pasteurized C1-inhibitor concentrate Prospective virus safety follow-up after therapy with a pasteurized C1-inhibitor concentrate Prophylactic treatment with pasteurised C1 inhibitor in herditary angioedema (HAE)-a prospective 32 months follow up Prospective follow up of clinical manifestation and therapy in children with hereditary angioedema (HAE) High-titer screening PCR: a successful strategy for reducing the parvovirus B19 load in plasma pools for fractionation Prospective audit of adverse reactions occurring in 459 primary antibody-deficient patients receiving intravenous immunoglobulin State of care for hemophilia in pediatric patients Hereditary angioedema Treatment of acute attacks of hereditary angioedema with C1-inhibitor concentrate Clinical studies of sudden upper airway obstruction in patients with hereditary angioedema due to C1 esterase inhibitor deficiency Proteolytic inactivation of plasma C1-inhibitor in sepsis Expression of active human C1 inhibitor serpin domain in Escherichia coli N-and O-glycans of recombinant human C1 Inhibitor expressed in the milk of transgenic rabbits Production of complex human glycoproteins in yeast Recombinant human C1-inhibitor produced in Pichia pastoris has the same inhibitory capacity as plasma C1-inhibitor Recombinant human C1-inhibitor produced in Pichia pastoris has the same inhibitory capacity as plasma C1-inhibitor Recombinant C1 inhibitor P5/P3 variants display resistance to catalytic inactivation by stimulated neutrophils The effect of danazol in the treatment of chronic cystic mastitis Danazol-induced pseudomenopause in the management of endometriosis Effects of danazol on pulsatile gonadotropin patterns and on serum estradiol levels in normally cycling women Cortical and trabecular bone mineral content in women with endometriosis: effect of gonadotropin-releasing hormone agonist and danazol A comparison of the skeletal effects of goserelin and danazol in premenopausal women with endometriosis Evidence of similar increases in bone turnover during nafarelin and danazol use in women with endometriosis Amino acids mutated in HAE patients are depicted in yellow ball-and-stick. keywords: aae; ace; activation; activity; acute; angioedema; angioedema attacks; attacks; bradykinin; c1 esterase; c1 inhibitor; c1nh; case; complement; concentrations; danazol; data; diagnosis; disease; effects; estrogen; factor; functional; gene; hae; hae attacks; hae patients; hae type; hereditary; human c1; inh; inh concentrate; inh concentrations; inh deficiency; inh function; inhibitor deficiency; kallikrein; life; mutations; normal; patients; plasma; plasma c1; prophylaxis; protein; results; studies; study; symptoms; system; term; therapy; treatment; type; use; women; xii cache: cord-269776-hj1s3ipp.txt plain text: cord-269776-hj1s3ipp.txt item: #87 of 171 id: cord-269975-1ebmq7t8 author: Duplantier, Allen J. title: Combating biothreat pathogens: ongoing efforts for countermeasure development and unique challenges date: 2020-05-27 words: 12977 flesch: 23 summary: infection Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430 BioCryst Pharmaceuticals BioCryst announces study results for BCX4430 in a non-human primate model of Ebola Virus infection BioCryst Pharmaceuticals BioCryst announces positive study results for BCX4430 delayed treatment of Ebola virus infection in a non-human primate model Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model Intracellular conversion and in vivo dose response of favipiravir (T-705) in rodents infected with Ebola virus Synthesis of [(18)F] favipiravir and biodistribution in C3H/HeN mice as assessed by positron emission tomography Efficacy of favipiravir (T-705) in nonhuman primates infected with Ebola virus or Marburg virus Post-exposure efficacy of oral T-705 (Favipiravir) against inhalational Ebola virus infection in a mouse model Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection Singledose pharmacokinetic study of clomiphene citrate isomers in anovular patients with polycystic ovary disease A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity Categorization and prioritization of drugs for consideration for testing or use in patients infected with Ebola Addressing therapeutic options for Ebola virus infection in current and future outbreaks A rapid screening assay identifies monotherapy with interferon-ss and combination therapies with nucleoside analogs as effective inhibitors of Ebola virus Evaluation of immune globulin and recombinant interferon-alpha2b for treatment of experimental Ebola virus infections Interferon-beta therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-ofconcept study Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates Discovery and early development of AVI-7537 and AVI-7288 for the treatment of Ebola virus and Marburg virus infections Advanced antisense therapies for postexposure protection against lethal filovirus infections A single phosphorodiamidate morpholino oligomer targeting VP24 protects rhesus monkeys against lethal Ebola virus infection A potent Lassa virus antiviral targets an arenavirus virulence determinant Favipiravir (T-705), a novel viral RNA polymerase inhibitor Lassa virus infection of rhesus monkeys: pathogenesis and treatment with ribavirin Usefulness of monitoring ribavirin plasma concentrations to improve treatment response in patients with chronic hepatitis C Stampidine prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by Lassa virus Zidampidine, an aryl phosphate derivative of AZT: in vivo pharmacokinetics, metabolism, toxicity, and anti-viral efficacy against hemorrhagic fever caused by Lassa virus Use of favipiravir to treat Lassa virus infection in macaques GuthrieW.I.P. Organization, N4-hydroxycytidine and derivatives and anti-viral uses related thereto Efficacy of a ML336 derivative against Venezuelan and eastern equine encephalitis viruses Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Monoclonal and cocktail antibody therapies approved by the Food and Drug Administration for countering anthrax and under development for treatment of Ebola virus infection are discussed. keywords: agents; animal; antibodies; antibody; biothreat; burkholderia; cell; combination; development; disease; drug; ebola; efficacy; fever; host; human; infection; inhibitors; model; pathogens; protein; pseudomallei; replication; resistance; screening; studies; target; therapy; treatment; virus; viruses cache: cord-269975-1ebmq7t8.txt plain text: cord-269975-1ebmq7t8.txt item: #88 of 171 id: cord-271436-h1xuhm1c author: Schleider, Jessica L. title: Retiring, Rethinking, and Reconstructing the Norm of Once-Weekly Psychotherapy date: 2020-09-28 words: 2488 flesch: 28 summary: However, repositioning evidencebased weekly therapy as one of many treatment options, and improving the availability of additional, diverse evidencebased service types, may strengthen the accessibility, flexibility, and potentially the effectiveness of mental health treatment overall. Treatment utilization patterns suggest that many clients cannot consistently access or complete weekly treatment involving months-long commitments; likewise, it is unrealistic to think this model would be preferable to individuals seeking high-quality care. keywords: evidence; health; therapy; treatment; weekly cache: cord-271436-h1xuhm1c.txt plain text: cord-271436-h1xuhm1c.txt item: #89 of 171 id: cord-274121-3w6kc0c9 author: Ramiro, Sofia title: Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study date: 2020-07-20 words: 5784 flesch: 43 summary: Control patients with COVID-19-associated CSS (same definition) were retrospectively sampled from the pool of patients (n=350) admitted between 7 March and 31 March, and matched one to one to treated patients on sex and age. control patients with coVid-19-associated css (same definition) were retrospectively sampled from the pool of patients (n=350) admitted between 7 march and 31 march, and matched one to one to treated patients on sex and age. keywords: care; control; covid-19; css; fees; group; hospital; mortality; patients; study; treatment; ventilation cache: cord-274121-3w6kc0c9.txt plain text: cord-274121-3w6kc0c9.txt item: #90 of 171 id: cord-275427-00bwhaga author: Aydogdu, Ugur title: The determination of treatment effect of chitosan oligosaccharide in lambs with experimentally cryptosporidiosis date: 2019-11-30 words: 5219 flesch: 50 summary: While all the lambs in the positive control group had oocyst excretion at the level of +1 on the 14th and 21st days, this level was found to be lower in treatment groups compared to the positive control group. key: cord-275427-00bwhaga authors: Aydogdu, Ugur; Coskun, Alparslan; Atas, Ahmet Duran; Basbug, Onur; Agaoglu, Zahid Tevfik title: The determination of treatment effect of chitosan oligosaccharide in lambs with experimentally cryptosporidiosis date: 2019-11-30 journal: Small Ruminant Research DOI: 10.1016/j.smallrumres.2019.09.021 sha: doc_id: 275427 cord_uid: 00bwhaga Abstract keywords: chitosan; cryptosporidiosis; day; days; group; lambs; treatment cache: cord-275427-00bwhaga.txt plain text: cord-275427-00bwhaga.txt item: #91 of 171 id: cord-275828-c6d6nk7x author: Mikasa, Keiichi title: JAID/JSC Guidelines for the Treatment of Respiratory Infectious Diseases: The Japanese Association for Infectious Diseases/Japanese Society of Chemotherapy – The JAID/JSC Guide to Clinical Management of Infectious Disease/Guideline-preparing Committee Respiratory Infectious Disease WG date: 2016-07-31 words: 39699 flesch: 37 summary: In the treatment of hospital-acquired pneumonia, the duration of antimicrobial therapy generally tends to be longer than required for the following reasons: opacity on chest X-ray often remains for reasons other than pneumonia even after the start of antimicrobial drug treatment; and there may be a large number of latent nonpneumonia (or non-infectious-disease) factors that may cause increase in body temperature or CRP level in inpatients (Table 5 GNR b ), the expression of intrinsic antimicrobial-drugresistance genes encoded in chromosome genes is induced during antimicrobial drug treatment, a phenomenon which is basically rarely seen in E. coli, Klebsiella spp., H. influenzae, and M. catarrhalis (Table 5 GNR a ) ( Table 5) keywords: administration; aspiration pneumonia; bacteria; cases; children; clinical; combination; community; day; days; diagnosis; disease; dose; drip; drug; drug therapy; guidelines; hospital; infection; japan; management; microorganisms; oral; patients; period; pneumonia; pulmonary; risk; severe; society; spp; study; susceptibility; symptoms; therapy; times; treatment; tuberculosis; type cache: cord-275828-c6d6nk7x.txt plain text: cord-275828-c6d6nk7x.txt item: #92 of 171 id: cord-279294-ruqednj6 author: Lin, Dong D. title: Chemotherapy Treatment Modifications During the COVID-19 Outbreak at a Community Cancer Center in New York City date: 2020-08-14 words: 3236 flesch: 37 summary: Oncologists had to consider the benefits of continuing or initiating cancer treatment, with many of these being myelosuppressive or immunosuppressive in nature, or both, against the risk of patients contracting the virus and developing severe complications. Medical oncology communities have developed treatment modifications to balance the risk of contracting the virus with the benefit of improving cancer-related outcomes. keywords: cancer; covid-19; disease; modifications; patients; providers; treatment cache: cord-279294-ruqednj6.txt plain text: cord-279294-ruqednj6.txt item: #93 of 171 id: cord-280111-6hiuzkvz author: Maspero, Cinzia title: Available Technologies, Applications and Benefits of Teleorthodontics. A Literature Review and Possible Applications during the COVID-19 Pandemic date: 2020-06-17 words: 6917 flesch: 41 summary: Indeed, an application for smartphones that allows remote monitoring of orthodontic patients using an algorithm of artificial intelligence, has recently been developed. The Italian Society of Orthodontics (SIDO) has recently published the recommended guidelines on the management of orthodontic patients during the COVID-19 outbreak. keywords: management; monitoring; office; patients; review; studies; study; teleassistance; teleorthodontics; time; treatment; visits cache: cord-280111-6hiuzkvz.txt plain text: cord-280111-6hiuzkvz.txt item: #94 of 171 id: cord-281561-r10y2sgb author: Tiwari, Nidhi title: Novel β-Coronavirus (SARS-CoV-2): Current and Future Aspects of Pharmacological Treatments date: 2020-08-27 words: 6887 flesch: 34 summary: The drugs at present used in COVID-19 patients and ongoing clinical trials focusing on drug repurposing of various therapeutic classes of drug e.g. antiviral, anti-inflammatory and/or immunomodulatory drugs along with adjuvant/supportive care. From this review, our aim is to provide a basic overview about currently available drugsand drugs under clinical trial for COVID-19 patients. keywords: coronavirus; cov-2; covid-19; disease; drug; efficacy; et al; infection; novel; patients; safety; sars; studies; study; treatment cache: cord-281561-r10y2sgb.txt plain text: cord-281561-r10y2sgb.txt item: #95 of 171 id: cord-282147-oq30pax6 author: Morris, Chad D. title: Nicotine and Opioids: a Call for Co-treatment as the Standard of Care date: 2020-06-03 words: 6614 flesch: 36 summary: 102, 103 The infrequency of appropriate referrals and evidence-based treatments point to the necessity of interdisciplinary healthcare teams as physicians are less responsive than other providers (e.g., nurse practitioners and physicians' assistants) to systemic efforts to increase tobacco cessation treatment. Key substance use and mental health indicators in the United States: results from the 2016 National Survey on Drug Use and Health Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration Benefits of and barriers to providing smoking treatment in methadone clinics: findings from a national study The health consequences of smoking: 50 years of progress. keywords: addiction; care; cessation; dependence; drug; health; nicotine; opioid; pain; patients; smoking; substance; tobacco; treatment; use cache: cord-282147-oq30pax6.txt plain text: cord-282147-oq30pax6.txt item: #96 of 171 id: cord-282446-01lu7sce author: Stokholm, Jakob title: Azithromycin for episodes with asthma-like symptoms in young children aged 1–3 years: a randomised, double-blind, placebo-controlled trial date: 2015-12-17 words: 5313 flesch: 42 summary: Figure 3 shows the reduction of episode duration after azithromycin treatment as a function of episode duration before treatment (less than or more than the median value of 6 days). This fi nding could point towards an anti-infl ammatory eff ect as the primary mediator of our fi ndings and also explain why fi ndings from previous RCTs 38, 39 have failed to show treatment eff ects of non-anti-infl ammatory antibiotics in acute exacerbations of childhood asthma. keywords: asthma; azithromycin; children; duration; ect; eff; episodes; lung; symptoms; treatment cache: cord-282446-01lu7sce.txt plain text: cord-282446-01lu7sce.txt item: #97 of 171 id: cord-283287-073r80s7 author: Farhoudian, Ali title: COVID-19 and Substance Use Disorders: Recommendations to a Comprehensive Healthcare Response. An International Society of Addiction Medicine Practice and Policy Interest Group Position Paper date: 2020-04-12 words: 8137 flesch: 34 summary: Additionally PWUDs live in crowded locations and so screening and early identification of COVID-19 patients are important to break the cycle of transmission. The Lancet Chronic cocaine abuse and dilated cardiomyopathy Prize-based contingency management for the treatment of substance abusers: A meta-analysis Voluntary versus prescribed termination of methadone maintenance Opioid substitution treatment planning in a disaster context: Perspectives from emergency management and health professionals in Aotearoa/New Zealand Forensic medicine and toxicology: Drug addiction Management of the opiate abstinence syndrome Opioid substitution treatment planning in a disaster context: Perspectives from emergency management and health professionals in Aotearoa/New Zealand Efavirenz treatment and falsepositive results in benzodiazepine screening tests Understanding links among opioid use, overdose, and suicide At least 44 dead from drinking toxic alcohol in Iran after coronavirus cure rumor Community engagement-the harms of drug prohibition: Ongoing resistance in Vancouver's Downtown Eastside Prevalence and risk factors for unrecognized obstructive lung disease among urban drug users Relapse and relapse prevention Determinants of influenza vaccination in hard-to-reach urban populations A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-March Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study Kidney impairment is associated with in-hospital death of COVID-19 patients. keywords: addiction; buprenorphine; care; coronavirus; covid-19; drug; et al; health; infection; management; methadone; opioid; patients; people; pwud; risk; services; stress; transmission; treatment; use cache: cord-283287-073r80s7.txt plain text: cord-283287-073r80s7.txt item: #98 of 171 id: cord-285898-rtqkvf63 author: Padberg, Stephanie title: Anti-infective Agents date: 2014-09-29 words: 24011 flesch: 39 summary: Results of a population-based Hungarian case-control study A case-control teratological study of spiramycin, roxithromycin, oleandomycin and josamycin A teratological study of lincosamides A population-based case-control teratologic study of oral oxytetracycline treatment during pregnancy A teratological study of aminoglycoside antibiotic treatment during pregnancy A population-based case-control teratologic study of oral chloramphenicol treatment during pregnancy Augmentin treatment during pregnancy and the prevalence of congenital abnormalities: a population-based case-control teratologic study Use of cephalosporins during pregnancy and in the presence of congenital abnormalities: a population-based, case-control study The teratogenic risk of trimethoprim-sulfonamides: a population based case-control study Nitrofurantoin and congenital abnormalities A population-based case-control study of the safety of oral anti-tuberculosis drug treatment during pregnancy A population-based case-control teratological study of vaginal econazole treatment during pregnancy A population-based case-control teratological study of oral nystatin treatment during pregnancy A case-control teratological study of vaginal natamycin treatment during pregnancy Preterm birth reduction after clotrimazole treatment during pregnancy Population-based case-control teratologic study of topical miconazole A population-based case-control study of oral griseofulvin treatment during pregnancy Tolnaftate spray treatment during pregnancy Effect of mebendazole therapy during pregnancy on birth outcome Periconceptional exposure to efavirenz and neural tube defects First-trimester itraconazole exposure and pregnancy outcome: a prospective cohort study of women contacting teratology information services in Italy Use of amphotericin B during pregnancy: case report and review The safety of the combination artesunate and pyrimethamine-sulfadoxine given during pregnancy Birth outcome of 1886 pregnancies after exposure to phenoxymethylpenicillin in utero The effects of telbivudine in late pregnancy to prevent intrauterine transmission of the hepatitis B virus: a systematic review and meta-analysis Pregnancy outcome after gestational exposure to mebendazole: a prospective controlled cohort study Pregnancy outcome after gestational exposure to metronidazole: a prospective controlled cohort study Genotoxicity and carcinogenicity of metronidazole Association between maternal fever and psychological/behavior outcomes: a hypothesis Safety of oseltamivir in pregnancy: a review of preclinical and clinical data Postmarketing surveillance of medications and pregnancy outcomes: clarithromycin and birth malformations Treatment of multidrug-resistant tuberculosis during pregnancy: long-term follow-up of 6 children with intrauterine exposure to second-line agents Increased risk of severe infant anemia after exposure to maternal HAART Pregnancy outcome following maternal use of zanamivir or oseltamivir during the 2009 influenza A/H1N1 pandemic: a national prospective surveillance study Europeans Guidelines for treatment of HIVinfected adults in Europe Hyperthermia and birth defects A retrospective review of ampicillin-sulbactam and amoxicillin + clavulanate vs cefazolin/cephalexin and erythromycin in the setting of preterm premature rupture of membranes: maternal and neonatal outcomes A prospective controlled multicentre study of clarithromycin in pregnancy Effect of quinine therapy on plasma glucose and plasma insulin levels in pregnant women infected with Plasmodium falciparum malaria in Gezira state Cryptococcal pneumonia complicating pregnancy Exposure to antiretroviral therapy in utero or early life: the health of uninfected children born to HIV-infected women Fosfomycin versus other antibiotics for the treatment of cystitis: a meta-analysis of randomized controlled trials Hematologic effects of maternal antiretroviral therapy and transmission prophylaxis in HIV-1-exposed uninfected newborn infants Birth defects in a national cohort of pregnant women with HIV infection in Italy Pharmacokinetics and safety of single-dose tenofovir disoproxil fumarate and emtricitabine in HIV-1-infected pregnant women and their infants Safety of efavirenz in the first trimester of pregnancy: an updated systematic review and meta-analysis Safety of efavirenz in first-trimester of pregnancy: a systematic review and meta-analysis of outcomes from observational cohorts Myelomeningocele in a child with intrauterine exposure to efavirenz Successful use of darunavir, etravirine, enfuvirtide and tenofovir/emtricitabine in pregnant woman with multiclass HIV resistance Maternal exposure to prescription and non-prescription pharmaceuticals or drugs of abuse and risk of craniosynostosis Pregnancy and infant outcomes among HIV-infected women taking long-term ART with and without tenofovir in the DART trial Placental transfer and pharmacokinetics of lopinavir and other protease inhibitors in combination with nevirapine at delivery Acyclovir pregnancy registry and valacyclovir pregnancy registry: Interim report for 1 Exposure to nitrofurantoin during the first trimester of pregnancy and the risk for major malformations Quinolone arthropathy -acute toxicity to immature articular cartilage Edwards: discoverer of maternal hyperthermia as a human teratogen Pharmacokinetics of sulfadoxinepyrimethamine in HIV-infected and uninfected pregnant women in Western Kenya Pharmacokinetics of oseltamivir according to trimester of pregnancy Maternal and neonatal outcomes after antepartum treatment of influenza with antiviral medications Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial Inadvertent exposure of pregnant women to ivermectin and albendazole during mass drug administration for lymphatic filariasis Lack of risk of adverse birth outcomes after deworming in pregnant women A prospective and open-label study for the efficacy and safety of telbivudine in pregnancy for the prevention of perinatal transmission of hepatitis B virus infection Lack of tumors in infants with perinatal HIV-1 exposure and fetal/neonatal exposure to zidovudine Review of beta-lactam antibiotics in pregnancy. ORACLE Collaborative Group Antifungal therapy during pregnancy Is gentamicin ototoxic to the fetus? Short-acting sulfonamides near term and neonatal jaundice Failure of metronidazole to prevent preterm delivery among pregnant women with asymptomatic Trichomonas vaginalis infection Prevalence of congenital anomalies in infants with in utero exposure to antiretrovirals No association between griseofulvin and conjoined twinning Drug rash with eosinophilia and systemic symptoms syndrome and renal toxicity with a nevirapine-containing regimen in a pregnant patient with human immunodeficiency virus Investigation of metronidazole use during pregnancy and adverse birth outcomes Use of antiretroviral therapy in pregnant HIVinfected women and the risk of premature delivery: a meta-analysis Transplacental passage of vancomycin in noninfected term pregnant women Serum erythromycin levels in pregnancy Birth outcome following maternal use of fluoroquinolones Perinatal antiretroviral treatment and hematopoiesis in HIV-uninfected infants Chloroquine pharmacokinetics in pregnant and nonpregnant women with vivax malaria Multidrug-resistant tuberculosis in pregnancy: case report and review of the literature Drug hepatotoxicity in pregnancy Increased risk of low birthweight and small for gestational age infants among women with tuberculosis Maternal exposure to amoxicillin and the risk of oral clefts Safety of macrolides during pregnancy Association of high-dose bifonazole administration during early pregnancy and severe limb reduction defects in the newborn Safety of telbivudine treatment for chronic hepatitis B for the entire pregnancy Pregnancy outcome following gestational exposure to fluoroquinolones: a multicenter prospective controlled study Prenatal exposure to fluconazole: an identifiable dysmorphic phenotype Erythromycin use during pregnancy in relation to pyloric stenosis Congenital defects among children born to women under supervision or treatment for pulmonary tuberculosis Successful use of dapsone in refractory pregnancy-associated idiopathic thrombocytopenic purpura Maternal and infant use of erythromycin and other macrolide antibiotics as risk factors for infantile hypertrophic pyloric stenosis First trimester use of macrolides and risk of major malformations {OTIS Abstract} Case report: nucleoside analogue-induced lactic acidosis in the third trimester of pregnancy Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1 Assessment of infant development during an 18-month follow-up after treatment of infections in pregnant women with cefuroxime axetil Safety of artemether-lumefantrine in pregnant women with malaria: results of a prospective cohort study in Zambia Safety and efficacy of fosamprenavir in human immunodeficiency virus-infected pregnant women Transplacental passage of protease inhibitors at delivery Prospective assessment of pregnancy outcomes after first-trimester exposure to fluconazole A systematic review of the impact of malaria prevention in pregnancy on low birth weight and maternal anemia Hepatotoxicity of erythromycin estolate during pregnancy Preliminary data on exposure to mebendazole during pregnancy {Abstract} A randomized comparison of artesunate-atovaquoneproguanil versus quinine in treatment for uncomplicated falciparum malaria during pregnancy Randomized comparison of mefloquine-artesunate versus quinine in the treatment of multidrug-resistant falciparum malaria in pregnancy Artemisinin antimalarials in pregnancy: a prospective treatment study of 539 episodes of multidrug-resistant Plasmodium falciparum The pharmacokinetics of atovaquone and proguanil in pregnant women with acute falciparum malaria A randomised controlled trial of artemetherlumefantrine versus artesunate for uncomplicated plasmodium falciparum treatment in pregnancy The effects of quinine and chloroquine antimalarial treatments in the first trimester of pregnancy High neonatal concentrations of raltegravir following transplacental transfer in HIV-1 positive pregnant women Treatment of vulvovaginal candidiasis in pregnancy. keywords: animal; birth; case; combination; data; defects; e.g.; effects; evidence; exposure; fetus; hiv; infections; malaria; malformations; population; pregnancy; pregnancy registry; recommendation; registry; risk; safety; second; studies; study; teratogenic; therapy; treatment; trimester; trimester exposure; use; women cache: cord-285898-rtqkvf63.txt plain text: cord-285898-rtqkvf63.txt item: #99 of 171 id: cord-288935-uwpkb6lm author: Cavaliere, Giulia title: Non-essential treatment? Sub-fertility in the time of COVID-19 (and beyond) date: 2020-08-31 words: 2020 flesch: 39 summary: Considering then the unprecedented health and economic crises that our societies are facing, and the burdens and costs associated with fertility treatment, one could conclude that this pandemic -and the consequent suspension of fertility treatments -might represent an opportunity to re-think the social value of genetic relatedness and fertility treatments. The Observer Haslanger, S. 2012 Resisting reality: Social construction and social critique How coronavirus is impacting cancer services in the UK On having an own child: Reproductive technologies and the cultural construction of childhood Marital stability and repartnering: Infertility-related stress trajectories of unsuccessful fertility treatment Infertility and moral luck: The politics of women blaming themselves for infertility Should fertility treatment be state funded American Society for Reproductive Medicine urges suspension of fertility treatments because of coronavirus Delay in IVF treatment up to 180 days does not affect pregnancy outcomes in women with diminished ovarian reserve What is the value of three-parent IVF keywords: fertility; norms; patients; treatments cache: cord-288935-uwpkb6lm.txt plain text: cord-288935-uwpkb6lm.txt item: #100 of 171 id: cord-289457-06gwrpu0 author: Berth, Sarah H. title: Secondary Causes of Myositis date: 2020-10-06 words: 3815 flesch: 25 summary: A randomized controlled phase II trial is underway examining tocilizumab treatment of myositis patients (ClinicalTrials.gov identifier: NCT02043548). A multicenter cooperative study Prostate cancer underlying acute, definitive dermatomyositis: successful treatment with radical perineal prostatectomy Cancerassociated myositis: clinical features and prognostic signs Sporadic inclusion body myositis: pilot study on the effects of a home exercise program on muscle function, histopathology and inflammatory reaction Improvement in aerobic capacity after an exercise program in sporadic inclusion body myositis Exercise in inflammatory myopathies, including inclusion body myositis Safety and efficacy of strength training in patients with sporadic inclusion body myositis Improvement in health and possible reduction in disease activity using endurance exercise in patients with established polymyositis and dermatomyositis: a multicenter randomized controlled trial with a 1-year open extension followup Benefits of intensive resistance training in patients with chronic polymyositis or dermatomyositis Community exercise is feasible for neuromuscular diseases and can improve aerobic capacity Rituximab in the treatment of inflammatory myopathies: a review Rituximab therapy for myopathy associated with anti-signal recognition particle antibodies: a case series Longitudinal course of disease in a large cohort of myositis patients with autoantibodies recognizing the signal recognition particle Rituximab in the treatment of refractory adult and juvenile dermatomyositis and adult polymyositis: a randomized, placebophase trial Although this study did not meet its primary endpoint, 83% patients with refractory dermatomyositis or polymyositis met definition of improvement Abatacept as a successful therapy for myositis-a case-based review Abatacept for severe immune checkpoint inhibitor-associated myocarditis Abatacept in the treatment of adult dermatomyositis and polymyositis: a randomised, phase IIb treatment delayed-start trial JAK inhibitor improves type I interferon induced damage: proof of concept in dermatomyositis Tofacitinib citrate for refractory cutaneous dermatomyositis: an alternative treatment A case of refractory dermatomyositis responsive to tofacitinib. keywords: body; dermatomyositis; disease; inclusion; myositis; patients; polymyositis; study; treatment cache: cord-289457-06gwrpu0.txt plain text: cord-289457-06gwrpu0.txt item: #101 of 171 id: cord-291417-p49ukyhx author: Mikulska, Malgorzata title: Tocilizumab and steroid treatment in patients with COVID-19 pneumonia date: 2020-08-20 words: 4449 flesch: 38 summary: Indeed, some real life experiences in COVID-19 patients showed that the use of antiinflammatory treatments might be beneficial [12] . The OW-weighted Cox proportional hazard regression model was used to calculate the adjusted hazard-ratio (HR OW ) of tocilizumab/methylprednisolone/SOC vs SOC patients. keywords: covid-19; days; failure; methylprednisolone; patients; pneumonia; soc; tocilizumab; treatment cache: cord-291417-p49ukyhx.txt plain text: cord-291417-p49ukyhx.txt item: #102 of 171 id: cord-291697-wpnq9wc0 author: Riechelmann, Rachel P title: Evidence-based recommendations for gastrointestinal cancers during the COVID-19 pandemic by the Brazilian Gastrointestinal Tumours Group date: 2020-05-22 words: 5873 flesch: 39 summary: A meta-analysis Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as firstline treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study Capecitabine and oxaliplatin for advanced esophagogastric cancer Capecitabine plus oxaliplatin compared with fluorouracil and folinic acid as adjuvant therapy for stage III colon cancer ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach A six-weekly (Q6W) dosing schedule for pembrolizumab based on an exposure-response (E-R) evaluation using modeling and simulation American College of Surgeons COVID-19: guidance for triage of non-emergent surgical procedures Staging investigations for oesophageal cancer: a meta-analysis Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a r Lancet Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial Optimal timing for postsurgical adjuvant therapy in patients with gastric cancer: a propensity score matching study Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer Cochrane database Syst Rev 8 CD010511 Pembrolizumab versus chemotherapy as second-line therapy for advanced esophageal cancer: phase III KEYNOTE-181 study Clinical Oncology COVID-19 Provider & Practice Information Centers for Disease Control and Prevention Interim Infection Prevention and Control Recommendations for Patients with Suspected or Confirmed Coronavirus Disease Individual patient data meta-analysis of the value of microsatellite instability as a biomarker in gastric cancer PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and managemen Neoadjuvant herapy followed by resection versus upfront resection for resectable pancreatic cancer: a propensity score matched analysis Preoperative chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: results of the Dutch Randomized Phase III PREOPANC Total neoadjuvant therapy with FOLFIRINOX followed by individualized chemoradiotherapy for borderline resectable pancreatic adenocarcinoma: a phase 2 clinical trial FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine FOLFIRINOX until progression, FOLFIRINOX with maintenance treatment, or sequential treatment with gemcitabine and FOLFIRI.3 for first-line treatment of metastatic pancreatic cancer: a randomized phase II trial (PRODIGE 35-PANOPTIMOX) Randomized, multicenter, phase II rial of gemcitabine and cisplatin with or without veliparib in patients with pancreas adenocarcinoma and a germline BRCA/PALB2 mutation Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer American Association of Transplantation 2019-nCoV (Coronavirus): FAQs for Organ Donation and Transplantation Utility of positron emission tomography-computed tomography scan in detecting residual hepatocellular carcinoma post treatment: Series of case reports IMbrave150: a randomized phase III study of 1L atezolizumab plus bevacizumab vs sorafenib in locally advanced or metastatic hepatocellular carcinoma Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial Sorafenib in advanced hepatocellular carcinoma Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): a randomised, multicentre, open-label, phase 2 study Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled Safety and efficacy of sorafenib in patients with Child-Pugh B advanced hepatocellular carcinoma Guidelines for the management of neuroendocrine tumours by the Brazilian gastrointestinal tumour group Ecancermedicalscience 11 716 Sunitinib malate for the treatment of pancreatic neuroendocrine tumors A randomized study of temozolomide or temozolomide and capecitabine in patients with advanced pancreatic neuroendocrine tumors: a trial of the ECOG-ACRIN Cancer Research Group (E2211) Opportunist and serious infections in patients with neuroendocrine tumours treated with everolimus: a multicenter study of real world patients International expert consensus statement regarding radiotherapy treatment options for rectal cancer during the COVID 19 pandemic Effect of adding mFOLFOX6 after neoadjuvant chemoradiation in locally advanced rectal cancer: a multicentre, phase 2 trial Randomized phase II trial of chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: CAO/ARO/AIO-12 Long-course oxaliplatin-based preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for cT4 or fixed cT3 rectal cancer: results of a randomized phase III study Total neoadjuvant therapy with short course radiation compared to concurrent chemoradiation in rectal cancer Achieving a complete clinical response after neoadjuvant chemoradiation that does not require surgical resection: it may take longer than you think! However, few data on the outcomes of cancer patients infected by SARS CoV-2 exist. keywords: cancer; chemotherapy; clinical; covid-19; disease; eor; metastatic; neoadjuvant; patients; phase; recommendations; surgery; treatment; tumours cache: cord-291697-wpnq9wc0.txt plain text: cord-291697-wpnq9wc0.txt item: #103 of 171 id: cord-292454-xa80078x author: Nazari, Nabi title: Transdiagnostic treatment of emotional disorders in people with multiple sclerosis: randomized controlled trial date: 2020-10-31 words: 5581 flesch: 36 summary: These results are the same that previous RCT, applying unified protocol in emotional disorders samples that have found changes in neuroticism/negative affect after unified protocol intervention [55] . Therapist guide therapist guide The unified protocol for transdiagnostic treatment of Emotional Disorders compared with diagnosisspecific protocols for anxiety disorders: a randomized clinical trial Applications of the unified protocol for transdiagnostic treatment of emotional disorders Efficacy of the unified protocol for the treatment of emotional disorders in the Spanish public mental health system using a group format: study protocol for a multicenter, randomized, non-inferiority controlled trial A systematic review and meta-analysis of the Unified Protocol as a transdiagnostic emotion regulation based intervention A unified, transdiagnostic treatment for adolescents with chronic pain and comorbid anxiety and depression The unified protocol for transdiagnostic treatment of emotional disorders American Psychiatric Association. keywords: anxiety; depression; disorders; emotion; group; protocol; pwms; regulation; sclerosis; study; treatment cache: cord-292454-xa80078x.txt plain text: cord-292454-xa80078x.txt item: #104 of 171 id: cord-293151-g3758oes author: Nemzek, Jean A. title: Biology and Diseases of Dogs date: 2015-07-10 words: 30311 flesch: 42 summary: Dogs have well developed olfactory glands, vision, and auditory and tactile senses that allow them to gain environmental cues and information from other dogs and humans (Field and Jackson, 2006; Joint Working Group on Refinement, 2004) . For example, from 3 to 8 weeks of age, puppies are most capable of learning about how to interact with other dogs. keywords: addition; age; animal; area; beagles; bitch; blood; body; canine; cases; catheter; cause; cell; chronic; complications; condition; control; days; diagnosis; disease; dogs; et al; etiology; ferguson; gland; helicobacter; hypothyroidism; infection; laboratory; lesions; lymphoma; mast; months; obesity; prevention; research; result; signs; skin; spp; stage; studies; study; systemic; therapy; time; tissue; transmission; treatment; tumors; use; weeks; weight; wound cache: cord-293151-g3758oes.txt plain text: cord-293151-g3758oes.txt item: #105 of 171 id: cord-294593-mh1uh1b3 author: Boloori, Alireza title: Misalignment of Stakeholder Incentives in the Opioid Crisis date: 2020-10-16 words: 6459 flesch: 31 summary: A cost-standardized enhanced recovery pathway for mastectomy decreases length of stay Evaluation of the fentanyl patch-for-patch program in Ontario Implementation of a pharmacy consult to reduce co-prescribing of opioids and benzodiazepines in a veteran population Quality measures to reduce opioid use after common soft tissue hand and wrist procedures Evaluation of machine-learning algorithms for predicting opioid overdose risk among medicare beneficiaries with opioid prescriptions The effect of a federal controlled substance act schedule change on hydrocodone combination products claims in a Medicaid population State legal restrictions and prescription-opioid use among disabled adults Goals of chronic pain management: Do patients and primary care physicians agree and does it matter? Patient-clinician communication about pain: A conceptual model and narrative review Methadone and buprenorphine for the management of opioid dependence: A systematic review and economic evaluation Exploring the concepts of abstinence and recovery through the experiences of long-term opiate substitution clients An observation of lower rates of drug use over time in community syringe exchangers Integrating screening, brief intervention, and referral to treatment (SBIRT) into clinical practice settings: A brief review Use of drug treatment services among adults with opioid use disorder: Rates, patterns, and correlates Integrating buprenorphine treatment into office-based practice: A qualitative study Policy pathways to address provider workforce barriers to buprenorphine treatment How Much Does Opioid Treatment Cost Risk factors for discontinuation of buprenorphine treatment for opioid use disorders in a multi-state sample of Medicaid enrollees Characteristics and prescribing practices of clinicians recently waivered to prescribe buprenorphine for the treatment of opioid use disorder Motivations for non-prescribed buprenorphine use in a time of treatment expansion The role of patient payment method in premature discharge from methadone maintenance treatment Acceptability of naloxone dispensing among pharmacists Gohns, A. Barriers to, and incentives for, the transfer of opioid-dependent people on methadone maintenance treatment from secondary care to primary health care Hospital nurses' attitudes toward patients with a history of illicit drug use Empowerment and pathologization: A case study in Norwegian mental health and substance abuse services Assessing service and treatment needs and barriers of youth who use illicit and non-medical prescription drugs in Northern Ontario Adoption of evidence-based clinical innovations: The case of buprenorphine use by opioid treatment programs Delivering opioid maintenance treatment in rural and remote settings Addressing Workforce Needs for Medication Treatment of Opioid Use Disorder Expanding the Use of Medications to Treat Individuals with Substance Use Disorders Federal Resources for Rural Communities to Help Address Substance Use Disorder and Opioid Misuse CVS Health Expands Efforts to Educate Patients about Naloxone Implementation of the hub and spoke model for opioid use disorders in California: Rationale, design and anticipated impact Participation in a hospital incentive program for follow-up treatment for opioid use disorder Help is on the way: Medicare coverage of opioid treatment programs Effects of global payment and accountable care on medication treatment for alcohol and opioid use disorders Behavioral contingencies improve counseling attendance in an adaptive treatment model Comparing adaptive stepped care and monetary-based voucher interventions for opioid dependence Effects of lower-cost incentives on stimulant abstinence in methadone maintenance treatment: A National Drug Abuse Treatment Clinical Trials Network study The cost-effectiveness of prize-based and voucher-based contingency management in a population of cocaine-or opioid-dependent outpatients Community opioid treatment perspectives on contingency management: Perceived feasibility, effectiveness, and transportability of social and financial incentives Adding an internet-delivered treatment to an efficacious treatment package for opioid dependence Effects of incentives for naltrexone adherence on opiate abstinence in heroin-dependent adults A financial incentive program to improve appointment attendance at a safety-net hospital-based primary care hepatitis C treatment program Effects of time-based administration of abstinence reinforcement targeting opiate and cocaine use I's on the prize: A systematic review of individual differences in Contingency Management treatment response Application of a discrete choice experiment approach to support the design of a hepatitis C testing service in primary care Acceptability and willingness to pay for contingency management interventions among parents of young adults with problematic opioid use Factors contributing to the rise of buprenorphine misuse Diversion of methadone and buprenorphine from opioid substitution treatment: Patients who regularly sell or share their medication Contingency management in cocaine abusers: A dose-effect comparison of goods-based versus cash-based incentives Counselor attitudes toward the use of motivational incentives in addiction treatment Improving substance abuse treatment enrollment in community syringe exchangers Improving treatment enrollment and re-enrollment rates of syringe exchangers: 12-month outcomes A mobile technology platform integrating motivational coaching, adherence monitoring, and electronic pill dispensing for enhancing buprenorphine/naloxone adherence during opioid use disorder treatment: A pilot study Acceptability and feasibility of a mobile health application for video directly observed therapy of buprenorphine for opioid use disorders in an office-based setting Development of an integrated digital health intervention to promote engagement in and adherence to medication for opioid use disorder Health status of employed and unemployed methadone patients Maintenance of reinforcement to address the chronic nature of drug addiction A community-based trial of vocational problem-solving to increase employment among methadone patients Combining stepped-care approaches with behavioral reinforcement to motivate employment in opioid-dependent outpatients A therapeutic workplace for the long-term treatment of drug addiction and unemployment: Eight-year outcomes of a social business intervention Employment-based reinforcement of adherence to an FDA approved extended release formulation of naltrexone in opioid-dependent adults: A randomized controlled trial Financial incentives promote engagement in employment services for unemployed adults in treatment for opioid use disorder Health benefits in 2019: key: cord-294593-mh1uh1b3 authors: Boloori, Alireza; Arnetz, Bengt B.; Viens, Frederi; Maiti, Taps; Arnetz, Judith E. title: Misalignment of Stakeholder Incentives in the Opioid Crisis date: 2020-10-16 journal: keywords: care; health; incentives; management; opioid; oud; pain; patients; prescribing; providers; review; sud; treatment; use cache: cord-294593-mh1uh1b3.txt plain text: cord-294593-mh1uh1b3.txt item: #106 of 171 id: cord-294624-d71za6hi author: Kapepula, Paulin M. title: Artemisia Spp. Derivatives for COVID-19 Treatment: Anecdotal Use, Political Hype, Treatment Potential, Challenges, and Road Map to Randomized Clinical Trials date: 2020-07-23 words: 2140 flesch: 34 summary: As the world desperately searches for new treatments to reduce rates of severe morbidity and mortality from COVID-19, the promotion of new drug discovery building on extracts from traditional medicinal plants should be encouraged. extracts for COVID-19 treatment in low-income countries has led to exaggerated and unproven claims of its efficacy in the absence of a scientific basis or results from clinical trials. keywords: annua; artemisia; artemisinin; compounds; covid-19; treatment cache: cord-294624-d71za6hi.txt plain text: cord-294624-d71za6hi.txt item: #107 of 171 id: cord-295445-f4p00yaw author: Wang, Hao title: Differential removal of human pathogenic viruses from sewage by conventional and ozone treatments date: 2018-02-01 words: 6892 flesch: 40 summary: Water Sa Evaluation of positively charged alumina nanofibre cartridge filters for the primary concentration of noroviruses, adenoviruses and male-specific coliphages from seawater Diarrhea and enteric emerging viruses in HIVinfected patients Detection of pathogenic viruses in sewage provided early warnings of hepatitis A virus and norovirus outbreaks Diversity of environmental single-stranded DNA phages revealed by PCR amplification of the partial major capsid protein New method using a positively charged microporous filter and ultrafiltration for concentration of viruses from tap water Mechanism of ozone inactivation of bacteriophage f2 Application of ozone for enhancing the microbiological safety and quality of foods: a review Disinfection of wastewater with peracetic acid: a review Environmental persistence and transfer of enteric viruses Mucosal and cutaneous human papillomaviruses detected in raw sewages Previously unknown evolutionary groups dominate the ssDNA gokushoviruses in oxic and anoxic waters of a coastal marine environment Quantitative RT-PCR for the enumeration of noroviruses (Norwalk-like viruses) in water and sewage Profile and fate of bacterial pathogens in sewage treatment plants revealed by high-Throughput metagenomic approach Presence of noroviruses and other enteric viruses in sewage and surface waters in The Netherlands Pathogenic enteric viruses and microbial indicators during secondary treatment of municipal wastewater Tracing of norovirus outbreak strains in mussels collected near sewage effluents Diversity of viruses associated with acute gastroenteritis in children hospitalized with diarrhea in Ho Chi Minh City, Vietnam Disinfection and oxidation of sewage effluent water using ozone and UV technologies Removal of viruses, parasitic protozoa and microbial indicators in conventional and membrane processes in a wastewater pilot plant Removal of noro-and enteroviruses, Giardia cysts, Cryptosporidium oocysts, and fecal indicators at four secondary wastewater treatment plants in Sweden Removal of noro-and enteroviruses Giardia cysts, Cryptosporidium oocysts, and fecal indicators at four secondary wastewater treatment plants in Sweden Visualizing phylogenetic trees using TreeView Effect of disinfection of drinking-Water with ozone or chlorine dioxide on survival of cryptosporidium-parvum oocysts Acute diarrhea in West African children: diverse enteric viruses and a novel parvovirus genus The fecal virome of South and Central American children with diarrhea includes small circular DNA viral genomes of unknown origin Wastewater disinfection with ozone -process control and operating results Uses of Ozone in Drinking Water Treatment Standard and new faecal indicators and pathogens in sewage treatment plants, microbiological parameters for improving the control of reclaimed water Reproducible (1)H NMRbased metabolomic responses in fish exposed to different sewage effluents in two separate studies Science and technology for water purification in the coming decades Tyrrell et al., 1995) , but knowledge regarding its effect for reducing human enteric viruses is relatively scarce. keywords: adenovirus; et al; human; min; ozone; pcr; samples; sewage; treatment; viruses; wastewater; water cache: cord-295445-f4p00yaw.txt plain text: cord-295445-f4p00yaw.txt item: #108 of 171 id: cord-296881-2g81sjnl author: Nabil, Ahmed title: Current coronavirus (SARS-CoV-2) epidemiological, diagnostic and therapeutic approaches: An updated review until June 2020 date: 2020-07-20 words: 4818 flesch: 30 summary: COVID-19 patients observed to have a dysfunction in the renin-angiotensin system (RAS). MSCs transplantation improved the outcome of COVID-19 patients. keywords: acute; cases; cells; coronavirus; cov-2; covid-19; disease; effects; infection; patients; potential; sars; treatment cache: cord-296881-2g81sjnl.txt plain text: cord-296881-2g81sjnl.txt item: #109 of 171 id: cord-297289-4kudq4h7 author: Hahn, Austin M. title: Risk reduction through family therapy (RRFT): Protocol of a randomized controlled efficacy trial of an integrative treatment for co-occurring substance use problems and posttraumatic stress disorder symptoms in adolescents who have experienced interpersonal violence and other traumatic events date: 2020-04-25 words: 6124 flesch: 33 summary: The hopelessness scale for children: psychometric properties with normal and emotionally disturbed adolescents Depression and attributions in children and adolescents: a meta-analytic review Longitudinal Data Analysis Integrated exposure-based therapy for cooccurring posttraumatic stress disorder and substance dependence: a randomized controlled trial Psychological interventions for post-traumatic stress disorder and comorbid substance use disorder: a systematic review and meta-analysis Rapid relapse generally follows treatment for substance use disorders among adolescents An overview of controlled studies of adolescent substance abuse treatment The Cannabis youth treatment (CYT) study: Main findings from two randomized trials Effects of comorbidity on treatment processes and outcomes among adolescents in drug treatment programs Efficacy of outpatient aftercare for adolescents with alcohol use disorders: a randomized controlled study A comprehensive and comparative review of adolescent substance abuse treatment outcome Adolescent Substance Abuse: Evidence-Based Approaches to Prevention and Treatment A comparison of exposure therapy, stress inoculation training, and their combination for reducing posttraumatic stress disorder in female assault victims Clinician perspectives on treating adolescents with co-occurring post-traumatic stress disorder, substance use, and other problems The safety and efficacy of exposure-based risk reduction through family therapy (RRFT) for co-occurring substance use problems and PTSD among adolescents: a randomized controlled trial Adolescent substance use following a deadly U.S. tornado outbreak: a population-based study of 2,000 families Third, the Stage II trial affords a unique opportunity to pursue mechanisms of action research, which can direct improvements to treatment models and inform important next steps in this line of research. keywords: abuse; adolescents; condition; family; ptsd; risk; rrft; study; substance; sup; therapy; treatment; use; youth cache: cord-297289-4kudq4h7.txt plain text: cord-297289-4kudq4h7.txt item: #110 of 171 id: cord-299926-jx1ws18b author: Gong, Yuan title: Effects of methylprednisolone use on viral genomic nucleic acid negative conversion and CT imaging lesion absorption in COVID‐19 patients under 50 years old date: 2020-05-22 words: 2123 flesch: 39 summary: With 931 persons becoming infected and the increasing number of COVID-19 patients, the medical resources of the Yichang Third People's Hospital were in short supply. A retrospective comparison study was performed on COVID-19 patients under 50 years old who were admitted between 30 January and 20 February 2020. keywords: corticosteroids; covid-19; group; methylprednisolone; patients; treatment cache: cord-299926-jx1ws18b.txt plain text: cord-299926-jx1ws18b.txt item: #111 of 171 id: cord-301370-nie7n6b5 author: Day, M.A. title: A randomized trial to examine the mechanisms of cognitive, behavioral and mindfulness-based psychosocial treatments for chronic pain: Study protocol date: 2020-04-14 words: 5589 flesch: 33 summary: The sessions will be conducted by a postdoctoral psychology fellow or licensed psychologist (the clinician) with at least two years of clinical experience, including experience working within the context of chronic pain treatment. Although some prior research has used EMA or actigraphy to evaluate treatment outcomes, e.g.,71,72 to the best of our knowledge, this study will be the first to utilize both actigraphy and EMA during pain treatment and during the critical month following administration of treatment to evaluate mechanisms. keywords: changes; condition; effects; mechanisms; mindfulness; outcome; pain; participants; study; therapy; treatment; variables cache: cord-301370-nie7n6b5.txt plain text: cord-301370-nie7n6b5.txt item: #112 of 171 id: cord-302215-sqrbj5r4 author: Vanden Eynde, Jean Jacques title: COVID-19: An Update about the Discovery Clinical Trial date: 2020-05-14 words: 3343 flesch: 44 summary: [2] , for a potential treatment, we analyzed the evolution of the number of clinical trials on April 8, April 28, and May 4. Comparison with clinical trials reported in the Chinese Clinical Trial Registry keywords: combination; covid-19; hydroxychloroquine; patients; remdesivir; treatment; trial cache: cord-302215-sqrbj5r4.txt plain text: cord-302215-sqrbj5r4.txt item: #113 of 171 id: cord-303661-etb19d6y author: Shin, Hyoung-Shik title: Empirical Treatment and Prevention of COVID-19 date: 2020-06-22 words: 4022 flesch: 38 summary: Tenofovir disoproxil fumarate/ emtricitabine (TDF/FTC), which has been prescribed for HIV-infected or hepatitis B virusinfected patients for a long time can be used safely as a short-term medicine for COVID-19 patients. Risk-adapted treatment strategy For COVID-19 patients Cytokine release syndrome in COVID-19 patients, a new scenario for an old concern: the fragile balance between infections and autoimmunity A review of unfractionated heparin and its monitoring Nebulized heparin is associated with fewer days of mechanical ventilation in critically ill patients: a randomized controlled trial Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics Teicoplanin: an alternative drug for the treatment of COVID-19? keywords: coronavirus; cov-2; covid-19; hypersensitivity; immunity; patients; pneumonia; sars; symptoms; treatment; virus cache: cord-303661-etb19d6y.txt plain text: cord-303661-etb19d6y.txt item: #114 of 171 id: cord-303816-c4z9ys3q author: Xu, YuShuang title: Diagnostic methods and drug therapies in patients with ischemic colitis date: 2020-09-16 words: 5057 flesch: 37 summary: Ischemic colitis (IC) is the most prevalent ischemic injury of thegastrointestinal tract. PubMed and Cochrane Library were searched toretrieve all published studies reporting the diagnostic methods and drugtherapies in patients with ischemic colitis. keywords: acute; colitis; colon; diagnosis; disease; drug; ischemic; patients; risk; studies; treatment cache: cord-303816-c4z9ys3q.txt plain text: cord-303816-c4z9ys3q.txt item: #115 of 171 id: cord-304479-uxp1kg86 author: Goodarzi, Pedram title: Coronavirus disease 2019 (COVID-19): Immunological approaches and emerging pharmacologic treatments date: 2020-08-08 words: 8115 flesch: 35 summary: Furthermore, there are some open clinical trials for the therapeutic assessment of methylprednisolone on COVID-19 patients [57] . [58] , shows that at least six different published studies on the effect of corticosteroids on COVID-19 patients. keywords: antiviral; cells; convalescent; coronavirus; cov-2; covid-19; disease; human; infection; patients; plasma; pneumonia; remdesivir; sars; study; therapy; treatment cache: cord-304479-uxp1kg86.txt plain text: cord-304479-uxp1kg86.txt item: #116 of 171 id: cord-305582-3hmsknon author: Li, Lei title: Therapeutic strategies for critically ill patients with COVID-19 date: 2020-04-20 words: 6194 flesch: 35 summary: Available drug options that come from the clinical experience of treating SARS, MERS and other previous influenza virus have been used for the treatment of COVID-19 patients. Considering the high incidence of bacterial infection for critically ill patients with COVID-19, it is essential to test the kinetics of procalcitonin (PCT) and C-reaction protein (CRP) in COVID-19 patients for timely diagnosis and intervention of bacterial infection. keywords: 2019; acute; antiviral; coronavirus; covid-19; infection; influenza; ncov; patients; sars; syndrome; therapy; treatment; ventilation cache: cord-305582-3hmsknon.txt plain text: cord-305582-3hmsknon.txt item: #117 of 171 id: cord-306266-8qdrshz3 author: Scully, Crispian title: Respiratory medicine date: 2014-06-25 words: 13246 flesch: 40 summary: Respiratory infections must also be eradicated; sputum should first be sent for culture and sensitivity, but antimicrobials such as amoxicillin should be started without await ing results. Immunocompromised persons (e.g. those with human immunode ficiency virus/acquired immune deficiency syndrome [HIV/AIDS] and transplant recipients) and people with bronchiectasis or cystic fibrosis are also susceptible to respiratory infections by a range of opportun istic microbes. keywords: asthma; blood; cases; cause; chest; copd; cough; diagnosis; disease; drugs; dyspnoea; infection; influenza; lung; obstruction; oxygen; patients; people; pneumonia; pulmonary; result; risk; sputum; symptoms; syndrome; table; therapy; treatment; tuberculosis cache: cord-306266-8qdrshz3.txt plain text: cord-306266-8qdrshz3.txt item: #118 of 171 id: cord-306600-cxz8hf9q author: Matarazzo, Laura title: Therapeutic Synergy Between Antibiotics and Pulmonary Toll-Like Receptor 5 Stimulation in Antibiotic-Sensitive or -Resistant Pneumonia date: 2019-04-09 words: 6572 flesch: 28 summary: Flagellin treatment alone decreased bacterial counts in the lungs by 5.6-fold, whereas AMX treatments decreased bacterial counts by 3.7-fold (for a dose of 100 µg) and 74.6-fold (for a dose of 350 µg). These results show a significant therapeutic advantage for the combination treatment, relative to standalone AMX or flagellin treatments ( Figure 4B) . keywords: amx; antibiotic; bacteria; cells; combination; figure; flagellin; infection; influenza; lung; mice; resistance; treatment cache: cord-306600-cxz8hf9q.txt plain text: cord-306600-cxz8hf9q.txt item: #119 of 171 id: cord-308169-a0ft6wdy author: Custovic, A. title: EAACI position statement on asthma exacerbations and severe asthma date: 2013-11-06 words: 7718 flesch: 30 summary: Recent joint modelling of longitudinal observations on wheezing from parental reports and medical records identified a novel phenotype of persistent troublesome wheeze with high rates of severe asthma exacerbations and healthcare utilization (24) . A decline in lung function has also been associated with severe asthma exacerbations in adult asthma (4) . keywords: airway; asthma; care; childhood; children; clinical; control; disease; exacerbations; lung; need; patients; risk; studies; study; treatment cache: cord-308169-a0ft6wdy.txt plain text: cord-308169-a0ft6wdy.txt item: #120 of 171 id: cord-309424-sfyagtl6 author: von Euler, H title: Cell proliferation and apoptosis in rat mammary cancer after electrochemical treatment (EChT) date: 2004-04-30 words: 4772 flesch: 46 summary: Moreover, nine positive controls (tumour cells inoculated and electrodes inserted but no electric treatment; three rats for each time period) and three negative controls; one for each time period (as for pos controls but only RPMI 1640 injected) were included in the study, making the total number of rats 36. Chart showing the cumulative incidence of tumour cells in S-phase from the border of destruction and out towards 'normal' tumour tissue. keywords: anode; apoptosis; cell; destruction; echt; mammary; min; proliferation; rats; tissue; treatment; tumour cache: cord-309424-sfyagtl6.txt plain text: cord-309424-sfyagtl6.txt item: #121 of 171 id: cord-312125-j9l6l3dx author: Pau, Alice K. title: Convalescent Plasma for the Treatment of COVID-19: Perspectives of the National Institutes of Health COVID-19 Treatment Guidelines Panel date: 2020-09-25 words: 1800 flesch: 42 summary: Given the lack of data from properly powered RCTs, and the need to inform regulatory decision making regarding continued access to convalescent plasma, both the FDA and the Mayo Clinic performed retrospective, indirect evaluations of efficacy by using EAP data, hypothesizing that patients who received plasma units with higher titers of neutralizing antibodies would have better clinical outcomes. Ann Intern Med DOI: 10.7326/m20-6448 sha: doc_id: 312125 cord_uid: j9l6l3dx In the United States, the efficacy and safety of convalescent plasma for treating coronavirus disease 2019 (COVID-19) is currently being tested in randomized placebo-controlled clinical trials. keywords: convalescent; covid-19; patients; plasma; treatment cache: cord-312125-j9l6l3dx.txt plain text: cord-312125-j9l6l3dx.txt item: #122 of 171 id: cord-313294-ffgo56gl author: Bertsimas, D. title: Personalized Prescription of ACEI/ARBs for Hypertensive COVID-19 Patients date: 2020-11-04 words: 7317 flesch: 41 summary: Pharmacologic treatments for coronavirus disease 2019 (covid-19): a review A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer Estimation and inference of heterogeneous treatment effects using random forests Good or bad: application of raas inhibitors in covid-19 patients with cardiovascular comorbidities Remdesivir in adults with severe covid-19: a randomised, double-blind, placebo-controlled, multicentre trial WHO (2020) The derivation cohort is comprised of data from 2,842 hypertensive patients from HOPE registry's hospitals in Spain and from HM Hospitals, also in Spain is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint Match treated and untreated populations based on clinical features and other treatments. keywords: acei; arbs; covid-19; data; models; morbidity; mortality; patients; preprint; prescription; rate; risk; treatment cache: cord-313294-ffgo56gl.txt plain text: cord-313294-ffgo56gl.txt item: #123 of 171 id: cord-313684-61hkogdh author: Samaddar, Arghadip title: Pathophysiology and Potential Therapeutic Candidates for COVID-19: A Poorly Understood Arena date: 2020-09-17 words: 11716 flesch: 34 summary: There are currently four ongoing clinical trials of umifenovir for COVID-19 treatment: one in comparison with the basic treatment 6 , and the other three comparing the effects in combination with oseltamivir 7 , lopinavir/ ritonavir 8 , and carrimycin. Currently, there are no clinically proven antiviral drugs or biologics for the treatment of COVID-19 patients. keywords: acute; antiviral; cells; combination; coronavirus; cov-2; covid-19; covid-19 patients; disease; et al; host; immune; infection; mers; patients; protein; receptors; response; rna; sars; therapy; treatment; trial; viral; virus cache: cord-313684-61hkogdh.txt plain text: cord-313684-61hkogdh.txt item: #124 of 171 id: cord-313894-stgx36h5 author: Ürün, Yüksel title: Survey of the Impact of COVID-19 on Oncologists’ Decision Making in Cancer date: 2020-08-05 words: 4287 flesch: 40 summary: The impact of COVID-19 outbreak on uro-oncological practice across Europe: Which burden of activity are we facing ahead? Risks from deferring treatment for genitourinary cancers: A collaborative review to aid triage and management during the COVID-19 pandemic Case fatality rate of cancer patients with COVID-19 in a New York hospital system The experience of treating patients with cancer during the COVID-19 pandemic in China TERAVOLT (Thoracic cancERs international coVid 19 cOLlaboraTion): First results of a global collaboration to address the impact of COVID-19 in patients with thoracic malignancies Managing patients with cancer during the COVID-19 pandemic: Frontline experience from Wuhan Patients with cancer appear more vulnerable to SARS-COV-2: A multicenter study during the COVID-19 outbreak Clinical characteristics of COVID-19-infected cancer patients: A retrospective case study in three hospitals within Wuhan, China Outcome of cancer patients infected with COVID-19, including toxicity of cancer treatments SARS-CoV-2 transmission in patients with cancer at a tertiary care hospital in Wuhan, China Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Caring for patients with cancer in the COVID-19 era European Association of Urology Guidelines Office Rapid Reaction Group: An organisation-wide collaborative effort to adapt the European Association of Urology Guidelines recommendations to the coronavirus disease 2019 era Advice regarding systemic therapy in patients with urological cancers during the COVID-19 pandemic Considerations in the triage of urologic surgeries during the COVID-19 pandemic The shifting landscape of genitourinary oncology during the COVID-19 pandemic and how Italian oncologists reacted: Results from a national survey How to guarantee the best of care to patients with cancer during the COVID-19 epidemic: The Italian experience Oncology practice during the COVID-19 pandemic The COVID-19 and Cancer Consortium (CCC19): A collaborative effort to understand the effects of COVID-19 on patients with cancer Impact of the COVID-19 pandemic on the symptomatic diagnosis of cancer: The view from primary care Lessons from a pooled meta-analysis Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: A population-based study (N = 4532) Impact of anti-androgenic therapies on COVID-19: An observational study in male population from a COVID-19 regional centre of Lombardy (Italy) Treatment of the immune-related adverse effects of immune checkpoint inhibitors: A review Determinants of severity in cancer patients with COVID-19 illness Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients Ethics and resource scarcity: ASCO recommendations for the oncology community during the COVID19 pandemic Crowdsourcing a crisis response for COVID-19 in oncology keywords: cancer; covid-19; oncologists; pandemic; participants; patients; risk; survey; treatment cache: cord-313894-stgx36h5.txt plain text: cord-313894-stgx36h5.txt item: #125 of 171 id: cord-314932-edf9xjwr author: Yan, Junqiang title: Research Progress of Drug Treatment in Novel Coronavirus Pneumonia date: 2020-05-13 words: 2989 flesch: 33 summary: In addition to being controlled through effective isolation, we need a rapid response from the healthcare and biotechnology industries to accelerate drug treatment research. By reviewing the currently available literature published at home and abroad, we summarize the current research progress of drug treatment during the epidemic period. keywords: coronavirus; interferon; ncov; novel; pneumonia; research; studies; treatment cache: cord-314932-edf9xjwr.txt plain text: cord-314932-edf9xjwr.txt item: #126 of 171 id: cord-315453-mbv8vb2r author: Jean, Shio-Shin title: Old and re-purposed drugs for the treatment of COVID-19 date: 2020-06-01 words: 3470 flesch: 32 summary: This article summarizes old drugs that could be potentially re-purposed for COVID-19 treatment. It was recommended for COVID-19 treatment by the National Health Commission and State Administration of Traditional Chinese Medicine in the 7th edition of their report, 'Novel Coronavirus Pneumonia Diagnosis and Treatment Plan' keywords: clinical; coronavirus; covid-19; drugs; efficacy; hydroxychloroquine; patients; sars; treatment cache: cord-315453-mbv8vb2r.txt plain text: cord-315453-mbv8vb2r.txt item: #127 of 171 id: cord-315730-fzgxuak7 author: Penman, Sophie L. title: Safety perspectives on presently considered drugs for the treatment of COVID‐19 date: 2020-07-17 words: 12087 flesch: 30 summary: As such, it is likely that many of the AEs observed in the Ebola study will translate to COVID-19 patients treated with remdesivir. However, a recent study found that only 4.1 % of COVID-19 patients receiving remdesivir treatment suffered serious (grade 3 or 4) transaminase elevations, with there being no significant difference between the remdesivir-and placebo-treated groups (Beigel et al., 2020) . keywords: anakinra; arthritis; baricitinib; coronavirus; cov-2; covid-19; covid-19 patients; disease; dose; drug; et al; hydroxychloroquine; ifn; infection; liver; patients; potential; remdesivir; rheumatoid; risk; safety; sars; study; tocilizumab; treatment; trial; use cache: cord-315730-fzgxuak7.txt plain text: cord-315730-fzgxuak7.txt item: #128 of 171 id: cord-316117-o29773cz author: Menzella, Francesco title: Pharmacologicaltreatment of COVID-19: lights and shadows date: 2020-05-19 words: 4471 flesch: 38 summary: Specifically, a cytokine profile resembling MAS has been noted in COVID-19 patients, with increased interleukin (IL)-1β, IL-2, IL-6, IL-17, IL-8, tumor necrosis factor, and C-C motif chemokine ligand 2. 12 Current recommendations for the treatment of COVID-19 severe cases consist of using existing, approved therapies with proven safety profiles to address the immediate need to reduce the rising mortality. Fighting viruses with antibiotics: an overlooked path Teicoplanin potently blocks the cell entry of 2019-nCoV Coagulopathy and antiphospholipid antibodies in patients with Covid-19 Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy Renin-angiotensin system blockers and the COVID-19 pandemic: at present there is no evidence to abandon renin-angiotensin system blockers Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension Preliminary identification of potential vaccine targets for the COVID-19 coronavirus (SARS-CoV-2) based on SARS-CoV immunological studies A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease Lack of peripheral memory B cell responses in recovered patients with severe acute respiratory syndrome: a six-year follow-up study Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection A sequence homology and bioinformatic approach can predict candidate targets for immune responses to SARS-CoV-2 Johnson Announces a Lead Vaccine Candidate for COVID-19 Department of Health & Human Services; and Commitment to Supply One Billion Vaccines Worldwide for Emergency Pandemic Use Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice Optimization of the production process and characterization of the yeast-expressed SARS-CoV recombinant receptor-binding domain (RBD219-N1), a SARS vaccine candidate Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate. keywords: coronavirus; cov-2; covid-19; drugs; efficacy; infection; patients; pneumonia; remdesivir; sars; syndrome; treatment cache: cord-316117-o29773cz.txt plain text: cord-316117-o29773cz.txt item: #129 of 171 id: cord-316370-t802kjpk author: Szperka, Christina L. title: Migraine Care in the Era of COVID‐19: Clinical Pearls and Plea to Insurers date: 2020-04-03 words: 4043 flesch: 41 summary: A randomized clinical trial Eptinezumab for prevention of chronic migraine: A randomized phase 2b clinical trial Eptinezumab in episodic migraine: A randomized, double-blind, placebo-controlled study (PROMISE-1) Prophylactic treatment of migraine with angiotensin converting enzyme inhibitor (lisinopril): Randomised, placebo controlled, crossover study Prophylactic treatment of migraine with an angiotensin II receptor blocker: A randomized controlled trial ACE and ARB agents in the prophylactic therapy of migraine-how effective are they? Efficacy of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the preventative treatment of episodic migraine in adults Efficacy of lisinopril in migraine prophylaxis -An open label study HFSA/ACC/ AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID-19 Randomised clinical trial comparing melatonin 3 mg, amitriptyline 25 mg and placebo for migraine prevention Use of melatonin versus valproic acid in prophylaxis of migraine patients: A double-blind randomized clinical trial. Further, given that nearly 1/5 of households in the United States reported a layoff or reduction in work hours related to coronavirus by March 14, 2020, 3 it is imperative that insurance providers minimize or eliminate copays for migraine medications. keywords: acute; care; covid-19; days; headache; migraine; patients; treatment; trial cache: cord-316370-t802kjpk.txt plain text: cord-316370-t802kjpk.txt item: #130 of 171 id: cord-317246-8c7d5ynz author: Cagetti, Maria Grazia title: Could SARS‐CoV‐2 burst the use of Non‐Invasive and Minimally Invasive treatments in paediatric dentistry? date: 2020-08-03 words: 2134 flesch: 40 summary: Non-operative caries treatment is mostly recommended for decayed primary teeth, but may represent a suitable alternative also for permanent teeth of children with dental anxiety or disabilities, who offer insufficient collaboration for the traditional restorative treatment. In addition to caries treatment, the minimally invasive treatment especially ART technique has proven to be an effective approach to preserving first permanent molars affected by severe form of MIH. keywords: caries; children; cov-2; dental; sars; treatment cache: cord-317246-8c7d5ynz.txt plain text: cord-317246-8c7d5ynz.txt item: #131 of 171 id: cord-317344-wznzmssz author: Iannitti, T. title: Therapeutical use of probiotic formulations in clinical practice date: 2010-06-23 words: 24555 flesch: 38 summary: The study showed the following results: one hundred subjects completed the study (48 in the probiotic combination group and 52 in the placebo group); the probiotic combination was not superior to the placebo in relieving symptoms of IBS (42.6% versus 42.3% improvement); the decrease of abdominal pain between the first and the fourth week of treatment was significantly higher in probiotic treated patients (À41.9 versus À24.2%, P ¼ 0.048). Sixty six patients (88%) were symptom-free after the 24th month of treatment: 11 of group M1, 8 of group M2, 15 of group LM1, 12 of group LM2 and 20 in group L. Four patients (5.33%) suspended the treatment during the follow-up: all experienced recurrence of symptoms (100%), and two of them developed diverticulitis (50%). keywords: activity; administration; authors; bacteria; bowel; cells; colon; daily; day; days; diarrhea; disease; effect; et al; group; ibs; lactobacillus; microbiota; p ¼; pain; patients; placebo; placebo group; probiotic; pylori; rhamnosus; strains; study; symptoms; therapy; treatment; trial; use; weeks cache: cord-317344-wznzmssz.txt plain text: cord-317344-wznzmssz.txt item: #132 of 171 id: cord-317538-i6amqpmt author: Krawczyk, Noa title: Lessons from COVID 19: Are we finally ready to make opioid treatment accessible? date: 2020-07-06 words: 955 flesch: 35 summary: key: cord-317538-i6amqpmt authors: Krawczyk, Noa; Fingerhood, Michael I.; Agus, Deborah title: Lessons from COVID 19: Are we finally ready to make opioid treatment accessible? date: 2020-07-06 journal: J Subst Abuse Treat DOI: 10.1016/j.jsat.2020.108074 sha: doc_id: 317538 cord_uid: i6amqpmt nan J o u r n a l P r e Existing models for services both in the U.S. and other countries exemplify the potential for offering opioid treatment through more accessible mechanisms (Krawczyk, Buresh, Gordon, Blue, et al, 2019; keywords: covid-19; health; opioid; treatment cache: cord-317538-i6amqpmt.txt plain text: cord-317538-i6amqpmt.txt item: #133 of 171 id: cord-318005-cxjnczwv author: Ormerod, A.D. title: Molluscum contagiosum effectively treated with a topical acidified nitrite, nitric oxide liberating cream date: 2001-12-24 words: 1711 flesch: 46 summary: We found a 75% cure rate in the active treatment group and 21% cure with control treatment (P = 0·01). Cure was significantly greater with NO treatment after 30 patients completed therapy, with 75% cure in the active treatment group and 21% cure with control treatment ( Table 2 ) (x 2 with Yates' correction P = 0´01, Fisher's exact test P , 0´01), and the mean time to cure^SD was 1´83^0´91 months. keywords: contagiosum; molluscum; patients; treatment cache: cord-318005-cxjnczwv.txt plain text: cord-318005-cxjnczwv.txt item: #134 of 171 id: cord-318797-iswxlbhb author: Bastier, P L title: Treatment of sleep apnea by ENT specialists during the COVID-19 pandemic date: 2020-05-11 words: 1577 flesch: 40 summary: Teleconsultation monitoring is advised for all modes of treatment, facilitated by service provider and/or manufacturer websites for CPAP treatment. According to those, CPAP treatment should be limited to severe forms of OSAS in the current context of COVID-19 pandemic. keywords: covid-19; cpap; pandemic; treatment cache: cord-318797-iswxlbhb.txt plain text: cord-318797-iswxlbhb.txt item: #135 of 171 id: cord-320548-oigyut2k author: Zumla, Alimuddin title: Emerging novel and antimicrobial-resistant respiratory tract infections: new drug development and therapeutic options date: 2014-09-01 words: 8128 flesch: 22 summary: A antibodies Antiviral combinations for severe infl uenza infections: a review Triple combination of amantadine, ribavirin, and oseltamivir is highly active and synergistic against drug resistant infl uenza virus strains in vitro Effi cacy of oseltamivirzanamivir combination compared to each monotherapy for seasonal infl uenza: a randomized placebo-controlled trial Triple-combination antiviral drug for pandemic H1N1 infl uenza virus infection in critically ill patients on mechanical ventilation Adjuvant treatment with a mammalian target of rapamycin inhibitor, sirolimus, and steroids improves outcomes in patients with severe H1N1 pneumonia and acute respiratory failure Anti-malaria drug chloroquine is highly eff ective in treating avian infl uenza A H5N1 virus infection in an animal model Eff ectiveness of chloroquine against infl uenza Chloroquine for infl uenza prevention: a randomised, double-blind, placebo controlled trial International Severe Acute Respiratory and Emerging Infections Consortium Treatment of MERS-CoV: information for clinicians. Romark announces clinical trial results for new infl uenza drug presented at IDSA meeting Eff ect of nitazoxanide in adults and adolescents with acute uncomplicated infl uenza: a double-blind, randomised, placebo-controlled, phase 2b/3 trial Adjunctive therapies and immunomodulatory agents in the management of severe infl uenza The eff ectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral aetiology: a systematic review and exploratory meta-analysis Convalescent plasma treatment reduced mortality in patients with severe pandemic infl uenza A (H1N1) 2009 virus infection Hyperimmune IV immunoglobulin treatment: a multicenter double-blind randomized controlled trial for patients with severe 2009 infl uenza A(H1N1) infection An in vivo human-plasmablast enrichment technique allows rapid identifi cation of therapeutic infl uenza keywords: antiviral; cells; clinical; drug; eff; infections; infl; infl uenza; oseltamivir; patients; resistance; respiratory; therapy; treatment; trial; tuberculosis; uenza; use; viral; virus cache: cord-320548-oigyut2k.txt plain text: cord-320548-oigyut2k.txt item: #136 of 171 id: cord-322279-6ffnejwj author: Kwon, Seungwon title: Could herbal medicine (Soshihotang) be a new treatment option for COVID-19?: A Narrative Review date: 2020-07-17 words: 4612 flesch: 41 summary: Based on this guideline, herbal medicine treatment has been used in more than 50% of confirmed patients with COVID-19 in J o u r n a l P r e -p r o o The search keywords included SSHT, constituents of SSHT, and antiviral effect. keywords: covid-19; disease; effect; hepatitis; liver; medicine; patients; ssht; symptoms; treatment; virus cache: cord-322279-6ffnejwj.txt plain text: cord-322279-6ffnejwj.txt item: #137 of 171 id: cord-322859-rtzf9dvp author: Kirkby, Charles title: Response to: low dose radiation therapy for COVID-19 pneumonia a double-edged sword date: 2020-05-07 words: 382 flesch: 37 summary: Even in the case of much higher palliative RT doses, consensus statements in the community suggest such treatments may proceed; concerns about population mixing and equipment sterilization notwithstanding. And while the interplay between radiation dose and viral activity is certainly complex, at the < 100 cGy doses proposed, it is unlikely that radiation-induced immunosuppression will have a significant impact on overall disease progression. keywords: covid-19; radiation cache: cord-322859-rtzf9dvp.txt plain text: cord-322859-rtzf9dvp.txt item: #138 of 171 id: cord-322980-rembksdr author: Talwar, Shivangi title: Ayurveda and Allopathic Therapeutic Strategies in Coronavirus Pandemic Treatment 2020 date: 2020-10-22 words: 4546 flesch: 42 summary: Therefore, Arsenicum album may be considered as a suitable remedy for COVID-19 treatment. This short review summarizes the role of allopathic and Ayurveda in coronavirus infections. keywords: ayurveda; coronavirus; covid-19; disease; homeopathy; infection; novel; pandemic; patients; review; sars; syndrome; treatment cache: cord-322980-rembksdr.txt plain text: cord-322980-rembksdr.txt item: #139 of 171 id: cord-323683-9h9mld6x author: Butler, M. title: Virus Removal by Disinfection of Effluents date: 2013-11-17 words: 6655 flesch: 39 summary: It is well known that at least a hundred different types of enteric viruses (Table 1 ) may be found in human faeces (Melnick, Gerba and Wallis, 1978) , of which at least some could be expected to be in final effluents. It'is also possible that certain viruses excreted with the urine could also be present (Utz, 1974) but in general, it is likely that the frequency and pathogenic potential of enteric viruses will be influenced by geographic, seasonal,as well as socioeconomic factors. keywords: acid; chlorine; disinfectant; disinfection; effluent; enteric; treatment; viruses; water cache: cord-323683-9h9mld6x.txt plain text: cord-323683-9h9mld6x.txt item: #140 of 171 id: cord-323940-ubazgvov author: Cafiero, Concetta title: Pharmacogenomics and Pharmacogenetics: In Silico Prediction of Drug Effects in Treatments for Novel Coronavirus SARS-CoV2 Disease date: 2020-10-13 words: 7372 flesch: 26 summary: • PharmGKB website provides a diverse array of PGx information, from annotations of the primary literature to guidelines for adjusting drug treatment based on genetic information. To our knowledge, although a considerable number of ADR episodes in Covid-19 patients have to date been described in the literature, there has been no pharmacogenetic study attempting to correlate the clinical outcomes of drug treatment with gene variants. keywords: coronavirus; cov2; covid-19; disease; drug; effects; efficacy; infection; patients; pharmacogenetic; response; sars; studies; study; therapy; toxicity; treatment; use; variants cache: cord-323940-ubazgvov.txt plain text: cord-323940-ubazgvov.txt item: #141 of 171 id: cord-324091-nljd2ok1 author: Gordon, Jennifer L. title: The psychological impact of fertility treatment suspensions during the COVID-19 pandemic date: 2020-09-18 words: 4515 flesch: 42 summary: Participants completed a battery of questionnaires assessing depressive symptoms, perceived mental health impact, and change in quality of life related to treatment suspensions. Neither age, years of education, annual income, nor the number of children a woman had were correlated with either change in quality of life or perceived mental health impact (p >.05). keywords: health; impact; infertility; life; quality; suspensions; treatment cache: cord-324091-nljd2ok1.txt plain text: cord-324091-nljd2ok1.txt item: #142 of 171 id: cord-325970-ivtunxrd author: Yerramilli, Divya title: Palliative Radiotherapy for Oncologic Emergencies in the setting of COVID-19: Approaches to Balancing Risks and Benefits date: 2020-04-08 words: 2726 flesch: 21 summary: Symptom monitoring with patient-reported outcomes during routine cancer treatment: a randomized controlled trial A predictive model for survival in metastatic cancer patients attending an outpatient palliative radiotherapy clinic Predicting life expectancy in patients with metastatic cancer receiving palliative radiotherapy: the TEACHH model Refining the TEACHH Model: Towards Improved Clinical Utility in the Modern Era How to Protect Yourself COVID-19) Ultra-rapid high dose irradiation schedules for the palliation of brain metastases: Final results of the first two studies by the radiation therapy oncology group A new scoring system to predicting the survival of patients treated with whole-brain radiotherapy for brain metastases Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: a randomized, double-blind, placebo-controlled trial Dexamethasone and supportive care with or without whole brain radiotherapy in treating patients with non-small cell lung cancer with brain metastases unsuitable for resection or stereotactic radiotherapy (QUARTZ): results from a phase 3, non-inferiority, randomised trial. Recent data from China and Italy have demonstrated that cancer patients have a higher risk of contracting the virus, as well as a higher case-fatality rate (9) (10) (11) (12) . keywords: cancer; palliative; patients; radiation; radiotherapy; treatment cache: cord-325970-ivtunxrd.txt plain text: cord-325970-ivtunxrd.txt item: #143 of 171 id: cord-326864-i1r3bv4p author: Hon, Kam Lun title: Coronavirus disease 2019 (COVID-19): latest developments in potential treatments date: 2020-06-29 words: 6276 flesch: 37 summary: A pneumonia outbreak associated with a new coronavirus of probable bat origin Clinical features of patients infected with 2019 novel coronavirus in Wuhan Pathological findings of COVID-19 associated with acute respiratory distress syndrome The clinical pathology of severe acute respiratory syndrome (SARS): a report from China Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of middle east respiratory syndrome coronavirus infection in the United Arab Emirates Severe acute respiratory syndrome vs. The Middle East respiratory syndrome Severe acute respiratory syndrome: SARS or not SARS Typical or atypical pneumonia and severe acute respiratory symptoms in PICU Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission Q&A: similarities and differences -COVID-19 and influenza Report of the WHO-China Joint Mission on Coronavirus Disease Solidarity clinical trial for COVID-19 treatments A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version) Intensive care management of coronavirus disease 2019 (COVID-19 ): challenges and recommendations Compassionate use of remdesivir for patients with severe covid-19 COVID-19 treatment: a review of early and emerging options Remdesivir as a possible therapeutic option for the COVID-19 Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial NIH clinical trial shows remdesivir accelerates recovery from advanced COVID-19 Gilead announces results from phase 3 trial of investigational antiviral remdesivir in patients with severe COVID-19 Study to evaluate the safety and antiviral activity of remdesivir (GS-5734 TM ) in participants with moderate coronavirus disease (COVID-19) compared to standard of care treatment Study to evaluate the safety and antiviral activity of remdesivir (GS-5734 TM ) in participants with severe coronavirus disease (COVID-19 Adaptive COVID-19 treatment trial Multi-centre, adaptive, randomized trial of the safety and efficacy of treatments of COVID-19 in hospitalized adults A trial of lopinavir-ritonavir in adults hospitalized with severe covid-19 Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro Lopinavir/ritonavir, ribavirin and IFN-beta combination for nCoV treatment Multicenter clinical study on the efficacy and safety of Xiyanping injection in the treatment of new coronavirus infection pneumonia (General and Severe An investigation into beneficial effects of interferon beta 1a, compared to interferon beta 1b and the base therapeutic regiment in moderate to severe COVID-19: a randomized clinical trial (DIC) Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: a multicentre retrospective matched cohort study Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial Novel coronavirus treatment with ribavirin: groundwork for an evaluation concerning COVID-19 SARS: systematic review of treatment effects Clinical features and short-term outcomes of 144 patients with SARS in the Greater Toronto area Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin National Health Commission & State Administration of Traditional Chinese Medicine. [34] [35] Therapeutics for COVID-19 The majority of COVID-19 patients, especially children, are either asymptomatic or have mild symptoms, and will likely recover by managing their own symptoms without the need for hospitalisation. keywords: clinical; coronavirus; cov-2; covid-19; disease; lopinavir; mers; patients; ritonavir; sars; syndrome; treatment; trial; use cache: cord-326864-i1r3bv4p.txt plain text: cord-326864-i1r3bv4p.txt item: #144 of 171 id: cord-327865-xxov2x33 author: Cisneros, B.J. title: Safe Sanitation in Low Economic Development Areas date: 2011-01-24 words: 30262 flesch: 48 summary: Unfortunately, even when treated, municipal discharges introduce used water containing used compounds, some of which are pollutants, to water bodies. Recently, some researchers have suggested (Asano, 2009) to use the term 'dispersion' instead of 'disposal' in order to change the perception of getting rid of used water, but this term has to an extent the connotation of wanting to dilute a problem. keywords: areas; conditions; content; control; cost; countries; development; eggs; environment; excreta; facilities; health; helminth; human; income; jiménez; management; need; people; plants; population; process; quality; reuse; sanitation; sewers; sludge; soil; systems; toilets; treatment; wastewater; wastewater treatment; water; water reuse; world cache: cord-327865-xxov2x33.txt plain text: cord-327865-xxov2x33.txt item: #145 of 171 id: cord-331487-jh34klbg author: Sivapalan, Pradeesh title: Proactive Prophylaxis With Azithromycin and HydroxyChloroquine in Hospitalised Patients With COVID-19 (ProPAC-COVID): A structured summary of a study protocol for a randomised controlled trial date: 2020-06-10 words: 6407 flesch: 42 summary: The length of hospitalisation is observed to be relatively long, 10-15 days (3) , which in itself is a problem as hospitals can quickly reach the maximum capacity for hospitalisation and the proportion of patients who become critically ill have, based on the observations reported so far, had a mortality rate of> 60% (4), and overall mortality for admitted patients in China with COVID-19 infection is apparently unusually high for viral respiratory tract infections with an estimate of 25% (2). Annual monitoring after 5 years of treatment is recommended, however in risk patients initially annual control, see also Chloroquine derivatives (inflammatory rheumatic diseases), side effects. keywords: azithromycin; consent; covid-19; data; days; group; hydroxychloroquine; information; intervention; medication; patients; project; study; treatment; trial cache: cord-331487-jh34klbg.txt plain text: cord-331487-jh34klbg.txt item: #146 of 171 id: cord-333730-qsx0m68e author: Tsai, Y. C. title: Oral disease-modifying antirheumatic drugs and immunosuppressants with antiviral potential, including SARS-CoV-2 infection: a review date: 2020-09-03 words: 4934 flesch: 26 summary: The Swiss HIV cohort study The HYDILE trial: efficacy and tolerance of a quadruple combination of reverse transcriptase inhibitors versus the same regimen plus hydroxyurea or hydroxyurea and interleukin-2 in HIV-infected patients failing protease inhibitorbased combinations Activity, safety, and immunological effects of hydroxyurea added to didanosine in antiretroviral-naive and experienced HIV type 1-infected subjects: a randomized, placebo-controlled trial, ACTG 307 A randomized trial to investigate the recycling of stavudine and didanosine with and without hydroxyurea in salvage therapy (RESTART) Hydroxyurea as an inhibitor of hepatitis C virus RNA replication Hydroxyurea suppresses HCV replication in humans: a phase I trial of oral hydroxyurea in chronic hepatitis C patients Amazing results with hydroxyurea therapy in chronic hepatitis B: a preliminary report Reactivation of hepatitis B virus during treatment with hydroxyurea in an elderly patient with essential thrombocythemia Reversible inhibition of herpes simplex virus replication by hydroxyurea Hydroxyurea enhances the activity of acyclovir and cidofovir against herpes simplex virus type 1 resistant strains harboring mutations in the thymidine kinase and/or the DNA polymerase genes Hydroxyurea inhibits parvovirus B19 replication in erythroid progenitor cells Original research: parvovirus B19 infection in children with sickle cell disease in the hydroxyurea era A novel action of minocycline inhibition of human immunodeficiency virus type 1 infection in microglia Neuroprotective and anti-human immunodeficiency virus activity of minocycline Minocycline treatment for HIV-associated 20 journals.sagepub.com/home/tab cognitive impairment: results from a randomized trial Randomized trial of minocycline in the treatment of HIV-associated cognitive impairment Minocycline neuroprotects, reduces microglial activation, inhibits caspase 3 induction, and viral replication following Japanese encephalitis Minocycline differentially modulates viral infection and persistence in an experimental model of Japanese encephalitis Minocycline trial in Japanese encephalitis: a double blind, randomized placebo study Role of oral minocycline in acute encephalitis syndrome in India: a randomized controlled trial Drug repurposing of minocycline against dengue virus infection Antibiotic minocycline prevents respiratory syncytial virus infection Antiinflammatory and antiviral effects of minocycline in enterovirus 71 infections Transcriptomic characterization of the novel avian-origin influenza A (H7N9) virus: specific host response and responses intermediate between avian (H5N1 and H7N7) and human (H3N2) viruses and implications for treatment options Minocycline inhibits West Nile virus replication and apoptosis in human neuronal cells Minocycline delays disease onset and mortality in reovirus encephalitis Therapy with minocycline aggravates experimental rabies in mice Effects of mycophenolic acid on human immunodeficiency virus infection in vitro and in vivo Mycophenolic mofetil, an alternative antiviral and immunomodulator for the highly pathogenic avian influenza H5N1 virus infection Broadspectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Inhibition of herpes simplex virus type 1 by the experimental immunosuppressive agent leflunomide Successful treatment of acyclovirresistant herpes simplex virus type 2 proctitis with leflunomide in an HIV-infected man Leflunomide in the treatment of a pseudotumoral genital herpes simplex virus infection in an HIV patient Inhibition of HIV replication by A77 1726, the active metabolite of leflunomide, in combination with pyrimidine nucleoside reverse transcriptase inhibitors Anti-HIV-1 activity of leflunomide: a comparison with mycophenolic acid and hydroxyurea Ther Adv Musculoskelet Dis DOI: 10.1177/1759720x20947296 sha: doc_id: 333730 cord_uid: qsx0m68e There have been several episodes of viral infection evolving into epidemics in recent decades, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the latest example. keywords: activity; covid-19; disease; hiv; hydroxyurea; infection; leflunomide; minocycline; patients; replication; sars; treatment; trial; virus cache: cord-333730-qsx0m68e.txt plain text: cord-333730-qsx0m68e.txt item: #147 of 171 id: cord-334867-ohw0chbg author: Ma, Hui title: Hospital biosecurity capacitation: Analysis and recommendations from the prevention and control of COVID-19 date: 2020-05-27 words: 3671 flesch: 20 summary: Infectious Disease Information Enlightenment of SARS, Ebola, and influenza A H1N1 on COVID-19 epidemic New progress in biosecurity medical treatment and clinical diagnosis and treatment of major infectious diseases Biosecurity discipline construction and capacity development in China Speed up the development of biosecurity science and technology in China with capacity building at the core Thoughts on the countermeasures of turning the emergency treatment stage into the continuous prevention and control stage at epidemic peak Suggestions on the reform of China's public health prevention system in COVID-19 epidemic Study on collaborative management of emergency supply chain of COVID-19 epidemic Study on dynamics of interregional collaborative allocation of emergency supplies for major infectious diseases Investigation on the core emergency capabilities of among medical staff in major infectious diseases Emergency research agenda for COVID-19: strategies for transmission and non-drug relief Analysis of the functional positioning of Chinese public health professionals under the new situation Thoughts and suggestions on modernization of disease prevention and control system Risk communication and community engagement (RCCE) readiness and response to the 2019 COVID-19 (2019-nCoV) interim guidance v2 Regional joint prevention and control of major diseases Not applicable Data sharing not applicable to this article as no datasets were generated or analyzed during the current study. This study examined the primary issues, including an absence of hospital emergency system, inadequate management and control of nosocomial infection, limited hospital laboratory capacity, and poor hospital admission capacity. keywords: biosecurity; control; covid-19; disease; emergency; epidemic; hospitals; infection; prevention; treatment cache: cord-334867-ohw0chbg.txt plain text: cord-334867-ohw0chbg.txt item: #148 of 171 id: cord-334881-x9nxxled author: Di Lorenzo, Giuseppe title: COVID 19 therapies and anti-cancer drugs: A systematic review of recent literature date: 2020-05-21 words: 3254 flesch: 35 summary: key: cord-334881-x9nxxled authors: Di Lorenzo, Giuseppe; Di Trolio, Rossella; Kozlakidis, Zisis; Busto, Giuseppina; Ingenito, Concetta; Buonerba, Luciana; Ferrara, Claudia; Libroia, Annamaria; Ragone, Gianluca; Ioio, Concetta dello; Savastano, Beatrice; Polverino, Mario; De Falco, Ferdinando; Iaccarino, Simona; Leo, Emilio title: COVID 19 therapies and anti-cancer drugs: A systematic review of recent literature date: 2020-05-21 journal: Crit Rev Oncol Hematol DOI: 10.1016/j.critrevonc.2020.102991 sha: doc_id: 334881 cord_uid: x9nxxled BACKGROUND: It is reasonable to think that cancer patients undergoing chemotherapy, targeted therapy or immunotherapy could have a more aggressive course if positive for Coronavirus disease CoV-2 (COVID- 19). Thus, during this COVID-19 crisis, cancer patients are regarded as a highly vulnerable group. keywords: cancer; coronavirus; covid-19; disease; drugs; patients; study; therapy; treatment cache: cord-334881-x9nxxled.txt plain text: cord-334881-x9nxxled.txt item: #149 of 171 id: cord-336462-7dltsav4 author: Trovik, Linn Hereide title: Hemophagocytic lymphohistiocytosis and miliary tuberculosis in a previously healthy individual: a case report date: 2020-11-11 words: 4241 flesch: 33 summary: Choose BMC Treatment outcomes and prognostic factors in adult patients with secondary hemophagocytic lymphohistiocytosis not associated with malignancy A consensus review on malignancy-associated hemophagocytic lymphohistiocytosis in adults COVID-19: consider cytokine storm syndromes and immunosuppression High serum ferritin concentration in an AIDS patient with miliary tuberculosis Immune thrombocytopenia secondary to tuberculosis: a case and review of literature Tuberculosis-associated hemophagocytic lymphohistiocytosis with initial presentation of fever of unknown origin in a general hospital: an analysis of 8 clinical cases HLH associated with disseminated tuberculosis Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study Etoposide selectively ablates activated T cells to control the immunoregulatory disorder hemophagocytic lymphohistiocytosis Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations However, these findings could not exclude TB infection. keywords: bone; diseases; failure; hlh; infection; lymphohistiocytosis; miliary; patient; treatment; tuberculosis cache: cord-336462-7dltsav4.txt plain text: cord-336462-7dltsav4.txt item: #150 of 171 id: cord-336554-n8n5ii5k author: Singh, Thakur Uttam title: Drug repurposing approach to fight COVID-19 date: 2020-09-05 words: 13068 flesch: 39 summary: Further, darunavir has been used (600 mg tablet every 12 h) along with other anti-viral drugs and supportive therapy in the clinical management of COVID-19 patients presented with a range of MEWS from less than 3 to more than 4 in Italy [33] . Hydroxychloroquine phosphate (400 mg tablet every 12 h as a loading dose followed 200 mg tablet every 12 h for 10 days) or chloroquine phosphate (250 mg of two tablet every 12 h for 10 days) along with other anti-viral drugs and supportive therapy have been used in the clinical management of COVID-19 patients presented with a range of MEWS from less than 3 to more than 4 in Italy keywords: antiviral; arbidol; clinical; coronavirus; cov2; covid-19; disease; dose; drug; effects; hydroxychloroquine; infection; inhibitors; interferon; lopinavir; patients; protease; remdesivir; ribavirin; ritonavir; sars; study; therapy; tocilizumab; treatment; trial; use cache: cord-336554-n8n5ii5k.txt plain text: cord-336554-n8n5ii5k.txt item: #151 of 171 id: cord-336563-hwemigk7 author: Bhimraj, Adarsh title: Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 date: 2020-04-27 words: 8317 flesch: 36 summary: A Randomized Control Trial (THDMS-COVID19) High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection Compassionate Use of Remdesivir for Patients with Severe COVID-19 SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor Vascular and upper gastrointestinal effects of nonsteroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials Non-steroidal anti-inflammatory drug induced acute kidney injury in the community dwelling general population and people with chronic kidney disease: systematic review and meta-analysis Nonsteroidal antiinflammatory drugs may affect the presentation and course of community-acquired pneumonia Risks Related to the Use of Non-Steroidal Anti-Inflammatory Drugs in Community-Acquired Pneumonia in Adult and Pediatric Patients Efficacy of Addition of Naproxen in the Treatment of Critically Ill Patients Hospitalized for COVID-19 Infection (ENACOVID) HFSA/ACC/AHA statement addresses concerns re: using RAAS antagonists in COVID-19 Treating COVID-19-Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics Editorial Concern-Possible Reporting of the Same Patients With COVID-19 in Different Reports Steroid therapy and the risk of osteonecrosis in SARS patients: a dose-response meta-analysis The Ebola clinical trials: a precedent for research ethics in disasters Clinical research ethics for critically ill patients: a pandemic proposal Early observational research and registries during the 2009-2010 influenza A pandemic Choosing outcomes for clinical trials: a pragmatic perspective In an open label treatment trial, lopinavir-ritonavir with ribavirin reduced the mortality and requirement of intensive care support of hospitalized SARS patients compared with historical control keywords: clinical; covid-19; disease; evidence; guideline; outcomes; panel; patients; recommendations; risk; sars; studies; treatment; trials; use cache: cord-336563-hwemigk7.txt plain text: cord-336563-hwemigk7.txt item: #152 of 171 id: cord-336614-u6alc6rs author: Pérez-Belmonte, Luis M. title: Differences between Clinical Protocols for the Treatment of Coronavirus Disease 2019 (COVID-19) in Andalusia, Spain date: 2020-09-19 words: 4741 flesch: 31 summary: The clinical presentation of the novel COVID-19 may vary from mild cases with fever, fatigue, and cough to moderate-severe cases involving pneumonia and multiorgan failure [10] , and several factors may predispose COVID-19 patients to adverse outcomes. The potential harm, such as delayed viral clearance, increased risk of secondary infection, and hyperglycemia episodes, have led to caution in their routine use in COVID-19 patients unless the patient had other conditions for which these are indicated keywords: covid-19; heparin; hospital; hydroxychloroquine; lopinavir; patients; pneumonia; protocols; treatment cache: cord-336614-u6alc6rs.txt plain text: cord-336614-u6alc6rs.txt item: #153 of 171 id: cord-339614-28s205p8 author: Dover, Jeffrey S. title: A Path to Resume Aesthetic Care: Executive Summary of Project AesCert Guidance Supplement—Practical Considerations for Aesthetic Medicine Professionals Supporting Clinic Preparedness in Response to the SARS-CoV-2 Outbreak date: 2020-05-01 words: 12539 flesch: 32 summary: Depending on the nature, duration and overall extent of the individual's activity in the office, including interactions with other patients, employees and others, the practice may need to consider further prophylactic measures up to and including temporary office closure, in order to minimize further exposure, ensure adequate site remediation, and assess the risk of further transmission. For all these reasons, consider limiting all such AGPs to one or more designated treatment rooms with appropriate air handling, containment and evacuation systems, in order to avoid exposing other treatment rooms or office areas. keywords: care; contact; covid-19; exposure; face; guidance; health; mask; office; patient; ppe; practice; procedures; risk; room; safety; staff; time; treatment; treatment room; use cache: cord-339614-28s205p8.txt plain text: cord-339614-28s205p8.txt item: #154 of 171 id: cord-342096-pijvvo2i author: Peivandi, S. title: Evaluation of attitude among infertile couples about continuing assisted reproductive technologies therapy during novel coronavirus outbreak date: 2020-09-03 words: 3789 flesch: 45 summary: Therefore, it is suspected that SARS-CoV-2 could be transmitted through sexual secretions (7) , and such concerns about infectious diseases can affect the process of continuing infertility treatment in infertile couples (11, 12) . Also, it has been reported that some viral infectious diseases such as Zika can cause abnormalities and microcephaly in the fetus (26) , which has influenced the attitude and decision of infertile couples to continue infertility treatment with ART (26, 27) . keywords: couples; covid-19; infertility; license; preprint; study; treatment cache: cord-342096-pijvvo2i.txt plain text: cord-342096-pijvvo2i.txt item: #155 of 171 id: cord-342128-x6z4nvt3 author: Ben-Arye, Eran title: Feasibility of an online integrative oncology treatment program during COVID-19 date: 2020-11-12 words: 1427 flesch: 34 summary: During the study period, patients continuing oncology treatment at the study centers were encouraged to participate in online treatments, as either an alternative or an 'add-on' to their current IO regimen. Nevertheless, the findings of the present study are encouraging, and suggest that online IO treatments are feasible and can be provided to patients, once challenges facing the ability to provide equitable and effective access to care are met. keywords: online; patients; treatment cache: cord-342128-x6z4nvt3.txt plain text: cord-342128-x6z4nvt3.txt item: #156 of 171 id: cord-342303-ddulfe06 author: Ismael, Julia title: Multidisciplinary approach to COVID-19 and cancer: consensus from scientific societies in Argentina date: 2020-05-13 words: 7129 flesch: 39 summary: Cancer patients are a very special population in this setting since they are more susceptible to viral infections than the general population. To review the evidence available in order to create a multi-institutional position from the perspective of scientific societies in Argentina involved in the management of cancer patients. keywords: cancer; cancer patients; care; cases; covid-19; health; infection; palliative; pandemic; panel; patients; recommendations; risk; therapy; treatment cache: cord-342303-ddulfe06.txt plain text: cord-342303-ddulfe06.txt item: #157 of 171 id: cord-342588-berrojmq author: Burri, Christian title: Sleeping Sickness at the Crossroads date: 2020-04-08 words: 5882 flesch: 42 summary: The need for a lumbar puncture was, for over 50 years, a characteristic of HAT treatment, a source of patient distress, stigma and technical limitation of treatment. The changes and significant impact on funding were later summarized in the landmark publication the new landscape of neglected disease drug development [12] . keywords: african; control; development; disease; drug; elimination; gambiense; hat; patients; sickness; treatment; trypanosomiasis cache: cord-342588-berrojmq.txt plain text: cord-342588-berrojmq.txt item: #158 of 171 id: cord-346607-1mewok8l author: Oesterle, Tyler S. title: Substance Use Disorders and Telehealth in the COVID-19 Pandemic Era: A New Outlook date: 2020-10-21 words: 4952 flesch: 40 summary: Many longitudinal outcome studies have allowed researchers to look at which aspects of SUD treatment patient have deemed most helpful to their recovery. A number of studies have shown group based treatment by videoconference, both support groups and treatment groups, including those targeting tobacco, alcohol and opioid use disorders have been shown to provide safe intervention, high patient satisfaction and appear to have similar outcomes to in person treatments. keywords: alcohol; care; covid-19; group; health; interventions; patients; sud; telehealth; treatment; use cache: cord-346607-1mewok8l.txt plain text: cord-346607-1mewok8l.txt item: #159 of 171 id: cord-346611-jyktuvyy author: Manski, C. F. title: How Should Clinicians Interpret Imprecise Trials Assessing Drugs for COVID-19 Patients? date: 2020-06-05 words: 8172 flesch: 52 summary: The mean welfare of patients treated according to statistical treatment rule δ over repeated realizations of the trial is is the expected (across potential samples) fraction of persons who will be assigned to treatment t. Application of statistical treatment rule δ in state of nature s leads to an expected loss (regret) equal to The near-optimality (maximum regret) of statistical treatment rule δ is the maximum value of (A1) over all feasible states of nature: First, we consider statistical treatment rules based on hypothesis tests for univariate outcomes y. Denote keywords: care; license; optimality; outcomes; patient; preprint; standard; treatment; trial cache: cord-346611-jyktuvyy.txt plain text: cord-346611-jyktuvyy.txt item: #160 of 171 id: cord-346715-r6a5vxl0 author: Liu, Haizhou title: Hexavalent chromium in drinking water: Chemistry, challenges and future outlook on Sn(II)- and photocatalyst-based treatment date: 2020-08-10 words: 4580 flesch: 35 summary: The challenges to overcome for a full-scale application in drinking water treatment include operational complexity, high chemical dosage requirement and secondary waste generation. Despite the unresolved issues, these nanomaterial based Cr(VI) treatment technologies are promising next-generation technologies for Cr(VI) removal in drinking water treatment. keywords: chromium; cr(iii; cr(vi; distribution; drinking; reductive; systems; treatment; water cache: cord-346715-r6a5vxl0.txt plain text: cord-346715-r6a5vxl0.txt item: #161 of 171 id: cord-349366-4gny9xkx author: Scanderbeg, Daniel J. title: Development, implementation, and associated challenges of a new HDR brachytherapy program date: 2020-09-17 words: 5132 flesch: 37 summary: brachytherapy is NOT optional Three-fraction accelerated partial breast irradiation (APBI) delivered with brachytherapy applicators is feasible and safe: first results from the TRIUMPH-T trial Predictors of quality of care and survival in a three-state cohort of locally advanced cervical cancer patients and development of a predictive model to identify women at risk of incomplete treatment National Cancer Institute. Many organizations, such as the IAEA, AAPM, AS-TRO, ESTRO, and Radiating Hope offer live training programs, whereas there are many other organizations that have begun to offer online distance education, such as Rayos Contra Cancer (https://www.rayoscontracancer.org/ ), and vendors offer user training on new equipment. keywords: applicator; brachytherapy; cancer; dose; equipment; hdr; planning; program; quality; radiation; training; treatment cache: cord-349366-4gny9xkx.txt plain text: cord-349366-4gny9xkx.txt item: #162 of 171 id: cord-349990-i3jslrae author: Visca, Dina title: Management of chronic refractory cough in adults date: 2020-09-19 words: 5981 flesch: 39 summary: The global epidemiology of chronic cough in adults: a systematic review and meta-analysis The impact of chronic cough: a cross-sectional European survey Chronic cough in adults Expert opinion on the cough hypersensitivity syndrome in respiratory medicine Chronic cough Chronic cough as a neuropathic disorder Voice and upper airway symptoms in people with chronic cough and paradoxical vocal fold movement Manometric evidence for a phonation-induced UES contractile reflex Speech pathology for chronic cough: a new approach Nonpharmacological interventions for refractory chronic cough patients: systematic review Efficacy of speech pathology management for chronic cough: a randomised placebo controlled trial of treatment efficacy Physiotherapy, and speech and language therapy intervention for patients with refractory chronic cough: a multicentre randomised control trial Over the past decade, international guidelines have been developed to help physicians in clinical practice to diagnose, assess the severity of, and manage cough -particularly chronic cough keywords: chronic; cough; gabapentin; management; patients; placebo; refractory; speech; study; treatment cache: cord-349990-i3jslrae.txt plain text: cord-349990-i3jslrae.txt item: #163 of 171 id: cord-350024-whne0l19 author: Anderson, Victoria L. title: Choosing the Right Antibiotic in Ambulatory Care date: 2006-11-28 words: 4737 flesch: 48 summary: Pediatric: neonates, uncircumcised boys, and children with functionally or anatomically abnormal urinary tracts are susceptible to urinary tract infections. Painful scrotal swelling that is often unilateral and can be associated with trauma, urinary tract infection, and STDs. keywords: acute; antibiotics; bacterial; day; days; diagnosis; disease; follow; hours; organisms; symptoms; treatment cache: cord-350024-whne0l19.txt plain text: cord-350024-whne0l19.txt item: #164 of 171 id: cord-350571-6tapkjb6 author: None title: 45th ESCP-NSF international symposium on clinical pharmacy: clinical pharmacy tackling inequalities and access to health care. Oslo, Norway, 5–7 October 2016 date: 2017-01-10 words: 106086 flesch: 45 summary: Clinical pharmacists have a role to evaluate and optimize the appropriateness and effectiveness of patient's medications. DTSIs interventions (treatment group) consist in: motivational interview, sharing and delivery of printed, explanatory material in the patient's native language, reconciliation of patients medications at hospital admission and at discharge; identification of potential risks due to drug-drug interactions; monitoring of compliance to drug therapy, and finally detection of adverse drug reactions (ADRs) occurring in the course of care. keywords: abstract; adherence; administration; admission; age; aim; analysis; antibiotics; assessment; associated; average; background; cancer; care; cases; clinical; community; conclusion; control; criteria; data; day; days; department; design; discharge; discrepancies; disease; dispensing; dosage; dose; drug; effects; following; general; group; guidelines; health; home; hospital; hospital pharmacy; impact; increase; information; interactions; interventions; knowledge; level; main; management; mean; measures; median; medical; medication; medication adherence; medication reconciliation; medicines; method; monitoring; months; n =; non; number; nurses; objective; oral; order; outcome; outcome measures; patients; period; pharmaceutical; pharmacists; pharmacy; physicians; potential; practice; prescribed; prescription; problems; process; projects; quality; research; results; review; risk; risk patients; role; safety; score; service; setting; study; survey; team; therapy; time; total; treatment; type; university; use; years cache: cord-350571-6tapkjb6.txt plain text: cord-350571-6tapkjb6.txt item: #165 of 171 id: cord-350578-wyz5jyjh author: Bai, Li title: Chinese experts’ consensus on the Internet of Things-aided diagnosis and treatment of coronavirus disease 2019 (COVID-19) date: 2020-12-31 words: 5459 flesch: 38 summary: To avoid misdiagnosis, suspected patients should be isolated and monitored for 14 days. nCapp intelligent assisted treatment and management for patients suspected of COVID-19 nCapp automatically generates prompt diagnosis according to the national guidelines, and patients who meet the criteria are suggested to be reported or transferred to the designated hospitals. keywords: cloud; coronavirus; covid-19; data; diagnosis; ncapp; online; patients; pneumonia; technology; treatment cache: cord-350578-wyz5jyjh.txt plain text: cord-350578-wyz5jyjh.txt item: #166 of 171 id: cord-351510-8m4930bc author: Aquino, Yves S J title: Hydroxychloroquine and COVID-19: critiquing the impact of disease public profile on policy and clinical decision-making date: 2020-07-09 words: 5068 flesch: 42 summary: As various expert panels and bodies have highlighted the threat to the HCQ supply for lupus patients generated by HCQ use in the treatment of COVID-19, 8 media reports of unusual prescribing patterns on the part of healthcare providers have emerged. key: cord-351510-8m4930bc authors: Aquino, Yves S J; Cabrera, Nicolo title: Hydroxychloroquine and COVID-19: critiquing the impact of disease public profile on policy and clinical decision-making date: 2020-07-09 journal: J Med Ethics DOI: 10.1136/medethics-2020-106306 sha: doc_id: 351510 cord_uid: 8m4930bc The controversy surrounding the use of hydroxychloroquine (HCQ), an antimalarial drug, for COVID-19 has raised numerous ethical and policy problems. keywords: case; consent; covid-19; disease; evidence; hcq; label; patients; profile; treatment; use cache: cord-351510-8m4930bc.txt plain text: cord-351510-8m4930bc.txt item: #167 of 171 id: cord-351555-hsgsuor2 author: Constantinou, Constantina title: Developing a holistic contingency plan: Challenges and dilemmas for cancer patients during the COVID‐19 date: 2020-07-20 words: 7598 flesch: 41 summary: key: cord-351555-hsgsuor2 authors: Constantinou, Constantina; Kolokotroni, Ourania; Mosquera, Maria‐Cecilia; Heraclides, Alexandros; Demetriou, Christiana; Karayiannis, Peter; Quattrocchi, Annalisa; Charalambous, Andreas title: Developing a holistic contingency plan: Challenges and dilemmas for cancer patients during the COVID‐19 date: 2020-07-20 journal: Cancer Med DOI: 10.1002/cam4.3271 sha: doc_id: 351555 cord_uid: hsgsuor2 During the first quarter of 2020 the world is experiencing a pandemic of Severe Acute Respiratory Syndrome‑Coronavirus‑2 (SARS‑CoV‑2), a novel beta coronavirus that is responsible for the 2019 novel coronavirus disease (COVID‐19). The COVID‐19 pandemic revealed that healthcare systems around the world were not prepared to deal with either the direct effects of the pandemic or with the indirect effects that are imposed on the health of patients with chronic disorders such as cancer patients. keywords: addition; cancer; cancer patients; care; coronavirus; covid-19; disease; healthcare; management; pandemic; patients; risk; sars; treatment cache: cord-351555-hsgsuor2.txt plain text: cord-351555-hsgsuor2.txt item: #168 of 171 id: cord-351594-8gp9mjen author: Garwood, Tyler J. title: Removal of chronic Mycoplasma ovipneumoniae carrier ewes eliminates pneumonia in a bighorn sheep population date: 2020-03-05 words: 5039 flesch: 42 summary: Synthesis and Applications: These results support the hypothesis that Mo is a primary causative agent of persistent or recurrent respiratory disease in bighorn sheep populations and can be maintained by a few chronic carriers. We found that pneumonia can be maintained in bighorn sheep populations by a few individuals chronically carrying Mo. After removing these individuals, we detected no deaths attributable to pneumonia and 76% of lambs survived to 6 months of age, similar to other healthy populations in our study region (37.5%-90%; Parr et al., 2018; Zimmerman, 2008) . keywords: bighorn; carriers; chronic; control; mortality; pneumonia; population; sheep; strain; treatment cache: cord-351594-8gp9mjen.txt plain text: cord-351594-8gp9mjen.txt item: #169 of 171 id: cord-353013-7cx0gnum author: DENG, Pengbo title: Bronchial Fistula: Rare Complication of Treatment with Anlotinib date: 2020-10-20 words: 4364 flesch: 51 summary: We aim to report 3 cases of rare complication of anlotinib-bronchial fistula (BF) during the treatment of lung cancer patients and summarize the possible causes. BPF is more common in lung cancer patients after surgery, directly caused by lung cancer invasion is rarely reported which usually combined with infection [15] . keywords: anlotinib; cancer; cell; fistula; line; lung; patients; treatment; tumor cache: cord-353013-7cx0gnum.txt plain text: cord-353013-7cx0gnum.txt item: #170 of 171 id: cord-353671-xjpzhsup author: Sgouros, George title: Radiopharmaceutical therapy in cancer: clinical advances and challenges date: 2020-07-29 words: 15007 flesch: 27 summary: xxxx Estimation of clinical trial success rates and related parameters Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials Targeted radionuclide therapy in combined-modality regimens Radioactive drugs emerge from the shadows to storm the market Radiosynovectomy in the therapeutic management of arthritis Local Treatment of Inflammatory Joint Diseases: Benefits and Risks Quantitative analyses of normal tissue effects in the clinic (QUANTEC): an introduction to the scientific issues The radiobiology of conventional radiotherapy and its application to radionuclide therapy Methodology to incorporate biologically effective dose and equivalent uniform dose in patient-specific 3-dimensional dosimetry for non Radiobiological aspects of low-dose rates in radioimmunotherapy Radiobiological treatment of RPT Radioimmunotherapy with alpha-emitting nuclides Radionuclide selection and model absorbed dose calculations for radiolabeled tumor associated antibodies Therapeutic applications of Auger and alpha emitting radionuclides Relationships between tumor size and curability for uniformly targeted therapy with beta-emitting radionuclides Therapeutic advantages of Auger electron-over beta-emitting radiometals or radioiodine when conjugated to internalizing antibodies Radionuclide therapy with iodine-125 and other Auger-electron-emitting radionuclides: experimental models and clinical applications Biophysical Aspects of Auger Processes Radiolabeled nucleoside analogs in cancer diagnosis and therapy Auger radiopharmaceutical therapy targeting prostate-specific membrane antigen Pilot clinical trial of 5-[ 125 I]iodo-2'-deoxyuridine in the treatment of colorectal cancer metastatic to the liver Pharmacokinetics and dosimetry of iodine-125-IUdR in the treatment of colorectal cancer metastatic to liver Mathematical model of 5-[ 125 I] iodo-2'-deoxyuridine treatment: continuous infusion regimens for hepatic metastases First human treatment of resistant neoplastic meningitis by intrathecal administration of MTX plus 125 IUdR Therapeutic efficacy and dose-limiting toxicity of Auger-electron vs. beta emitters in radioimmunotherapy with internalizing antibodies: evaluation of 125 I-vs. 131 I-labeled CO17-1A in a human colorectal cancer model Auger electrons for cancer therapy -a review Metal complexes of bleomycin: evaluation of [Rh-105]-bleomycin for use in targeted radiotherapy Therapeutic efficacy of a 188 Re-labeled alpha-melanocyte-stimulating hormone peptide analog in murine and human melanoma-bearing mouse models Comparison between three promising ß-emitting radionuclides 47 Sc and 161 Tb, with emphasis on doses delivered to minimal residual disease Application of the linear-quadratic model to radioimmunotherapy: further support for the advantage of longer-lived radionuclides A model of the peritoneal cavity for use in internal dosimetry Why are investors not interested in my radiotracer? Prospects for imaging and therapy Review of therapeutic applications of radiolabeled functional nanomaterials Antibody-targeted liposomes in cancer therapy and imaging Radioembolization for the treatment of primary and metastatic liver cancers Arming antibodies: prospects and challenges for immunoconjugates Minibody: a novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-C H 3) which exhibits rapid, high-level targeting of xenografts Tumor localization of anti-CEA single-chain Fvs: improved targeting by non-covalent dimers Single-chain Fv-streptavidin substantially improved therapeutic index in multistep targeting directed at disialoganglioside GD2 Pretargeting of renal cell carcinoma: improved tumor targeting with a bivalent chelate Molecular advances in pretargeting radioimunotherapy with bispecific antibodies Bispecific antibody pretargeting PET (ImmunoPET) with an I-124-labeled haptenpeptide Treatment of cancer of the thyroid postoperatively with suppressive thyroid medication, radioactive iodine, and thyroid-stimulating hormone Studies in iodine metabolism of the thyroid gland in situ by the use of radio-iodine in normal subjects and in patients with various types of goiter Relation of radioiodine dosimetry to results and complications in treatment of metastatic thyroid cancer Relation between effective radiation dose and outcome of radioiodine therapy for thyroid cancer Radioactive iodine isotopes Radiopharmaceuticals for Therapy -2016 Radioactive iodine as an indicator in thyroid physiology -Iodine collection by normal and hyperplastic thyroids in rabbits Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer Biologic and clinical perspectives on thyroid cancer Internal radiotherapy using 32 P colloid or microsphere for refractory solid tumors Radium-223 mechanism of action: implications for use in treatment combinations Dose-dependent growth delay of breast cancer xenografts in the bone marrow of mice treated with 223 Ra: the role of bystander effects and their potential for therapy Decreased fracture rate by mandating bone-protecting agents in the EORTC 1333/PEACE III trial comparing enzalutamide and Ra223 versus enzalutamide alone: an interim safety analysis ERA 223: a phase 3 trial of radium-223 dichloride (Ra-223) in combination with abiraterone acetate (abiraterone) and prednisone in the treatment of asymptomatic or mildly symptomatic chemotherapy-naïve patients (pts) with bone predominant metastatic castration-resistant prostate cancer (mCRPC) Higher risk of fragility fractures in prostate cancer patients treated with combined radium-223 and abiraterone: prednisone may be the culprit Overview of samarium Sm 153 lexidronam in the treatment of painful metastatic bone disease Current Advances in Osteosarcoma Samarium-153-ethylene diamine tetramethylene phosphonate, a beta-emitting bone-targeted radiopharmaceutical, useful for patients with osteoblastic bone metastases Sm-EDTMP on calcium hydroxyapatite Samarium-153-EDTMP biodistribution and dosimetry estimation Bone-targeting radiopharmaceuticals for the treatment of prostate cancer with bone metastases Preclinical evaluation of Sm-153-DOTMP as a therapeutic bone-seeking radiopharmaceutical A preclinical investigation of the saturation and dosimetry of 153 Sm-DOTMP as a bone-seeking radiopharmaceutical I-131-mIBG therapy in neuroblastoma: established role and prospective applications keywords: 131; agents; alpha; antibodies; antibody; bone; cancer; cells; delivery; dose; dosimetry; efficacy; imaging; metastatic; particle; patients; phase; prostate; psma; radiation; radionuclide; rpt; study; targeted; targeting; therapeutic; therapy; treatment; trial; tumour cache: cord-353671-xjpzhsup.txt plain text: cord-353671-xjpzhsup.txt item: #171 of 171 id: cord-354824-7fdcu2f0 author: Wu, Renyi title: An Update on Current Therapeutic Drugs Treating COVID-19 date: 2020-05-11 words: 9676 flesch: 38 summary: Chinese Clinical Trial Registry Why tocilizumab could be an effective treatment for severe COVID-19? Evaluation of the efficacy and safety of sarilumab in hospitalized patients with COVID-19 Overview of the IL-1 family in innate inflammation and acquired immunity Personalised immunotherapy for SARS-CoV-2 (COVID-19) associated with organ dysfunction Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Clinical characteristics of coronavirus disease 2019 in China Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus Genetic associations between genes in the renin-angiotensinaldosterone system and renal disease: a systematic review and meta-analysis Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensinconverting enzyme 2 A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury FDA advises patients on use of non-steroidal anti-inflammatory drugs (NSAIDs) for COVID-19 Peroxisome proliferatoractivated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells Treating viral exacerbations of chronic obstructive pulmonary disease: insights from a mouse model of cigarette smoke and H1N1 influenza infection Indomethacin has a potent antiviral activity against SARS coronavirus Colchicine-update on mechanisms of action and therapeutic uses Colchicine and the heart: pushing the envelope Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-coronavirus infection An AlphaScreen®-based assay for high-throughput screening for specific inhibitors of nuclear import Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug The broad spectrum antiviral ivermectin targets the host nuclear transport importin alpha/beta1 heterodimer The FDAapproved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro A screen of the NIH clinical collection small molecule library identifies potential anti-coronavirus drugs Nitazoxanide, a new drug candidate for the treatment of Middle East respiratory syndrome coronavirus Meta-analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment? Antibody-mediated regulation of cellular immunity and the inflammatory response Serum therapy revisited: animal models of infection and development of passive antibody therapy Fcmediated antibody effector functions during respiratory syncytial virus infection and disease A role for Fc function in therapeutic monoclonal antibody-mediated protection against Ebola virus A serological survey on neutralizing antibody titer of SARS convalescent sera Use of convalescent plasma therapy in SARS patients in Hong Kong Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: a single centre experience Deployment of convalescent plasma for the prevention and treatment of COVID-19 Treatment of 5 critically ill patients with COVID-19 with convalescent plasma Effectiveness of convalescent plasma therapy in severe COVID-19 patients Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 receptor binding domain The potential of low molecular weight heparin to mitigate cytokine storm in severe COVID-19 patients: a retrospective clinical study Redeploying plant defences Chinese herbal medicines for the treatment of type a H1N1 influenza: a systematic review of randomized controlled trials Clinical outcomes of influenza-like illness treated with Chinese herbal medicine: an observational study Herbal medicine and pattern identification for treating COVID-19: a rapid review of guidelines Traditional Chinese medicine in the treatment of patients infected with 2019-new coronavirus (SARS-CoV-2): a review and perspective Investigating mechanism of Qingfei Dayuan granules for treatment of COVID-19 based on network pharmacology and molecular docking Study on screening potential traditional Chinese medicines against 2019-nCoV based on Mpro and PLP Chinese herbal medicine for severe acute respiratory syndrome: a systematic review and metaanalysis Traditional Chinese herbal medicine as a source of molecules with antiviral activity Can Chinese medicine be used for prevention of corona virus disease 2019 (COVID-19)? Evolving research and clinical data regarding the virologic SARS-CoV-2 suggest a potential list of repurposed drugs with appropriate pharmacological effects and therapeutic efficacies in treating COVID-19 patients. keywords: activity; antiviral; azithromycin; cells; clinical; coronavirus; cov-2; covid-19; disease; drugs; hydroxychloroquine; infection; influenza; lung; patients; rna; sars; study; syndrome; treatment; trial; viral cache: cord-354824-7fdcu2f0.txt plain text: cord-354824-7fdcu2f0.txt