item: #1 of 115 id: cord-000402-unr44dvp author: Yoo, Hyun Jung title: Gene Expression Profile during Chondrogenesis in Human Bone Marrow derived Mesenchymal Stem Cells using a cDNA Microarray date: 2011-06-20 words: 3189 flesch: 37 summary: The role of peroxiredoxin-1 in cell differentiation and proliferation suggests that it has a possible role in growth and development. HSF-2 plays an important role in FGF-2 stimulated osteoclast formation, and HSF-2 deficiency was found to modulate gene expression in stromal/ preosteoblast cells and affect osteoclastogenesis in the bone microenvironment (18) . keywords: bone; cells; chondrogenesis; differentiation; expression; genes; human; microarray; mscs cache: cord-000402-unr44dvp.txt plain text: cord-000402-unr44dvp.txt item: #2 of 115 id: cord-000698-v9k7vpi8 author: St. Leger, Judy title: West Nile Virus Infection in Killer Whale, Texas, USA, 2007 date: 2011-08-17 words: 1408 flesch: 43 summary: Among marine mammals, WNV infection has been reported in a harbor seal (Phoca vitulina) (1) . We describe WNV infection in a killer whale (Orcinus orca) and seroprevalence in conspecifi c cohort and noncohort groups. keywords: animals; killer; microarray; usa; wnv cache: cord-000698-v9k7vpi8.txt plain text: cord-000698-v9k7vpi8.txt item: #3 of 115 id: cord-001117-llb4f74a author: Ji, Wen-Jie title: Spironolactone Attenuates Bleomycin-Induced Pulmonary Injury Partially via Modulating Mononuclear Phagocyte Phenotype Switching in Circulating and Alveolar Compartments date: 2013-11-19 words: 4983 flesch: 28 summary: In addition, recent studies demonstrated that lung alveolar macrophages are established prior to birth and maintains themselves subsequently during adulthood independent of replenishment from circulating monocyte input in steady state Second, we did not observed significant changes in lung interstitial macrophages by spironolactone. keywords: alveolar; analysis; bleomycin; cells; fibrosis; inflammation; injury; lung; macrophages; monocytes; mouse; spironolactone; tissue cache: cord-001117-llb4f74a.txt plain text: cord-001117-llb4f74a.txt item: #4 of 115 id: cord-001383-hww0watl author: Li, Wenchao title: Self-Assembly and Release of Peste des Petits Ruminants Virus-Like Particles in an Insect Cell-Baculovirus System and Their Immunogenicity in Mice and Goats date: 2014-08-12 words: 6565 flesch: 41 summary: No N protein-specific antibodies were found in goats vaccinated with PPRV H or PPRV F VLPs; in contrast, seroconversion to N protein was detected in goats vaccinated with the PPRV Nig 75/1 attenuated virus (data not shown). To date, the assembly and release of PPRV VLPs have not been well characterized, and their immunogenicity remains unknown. keywords: baculovirus; cells; expression; goats; h vlps; insect; mice; particles; pprv; protein; ruminants; virus; vlps cache: cord-001383-hww0watl.txt plain text: cord-001383-hww0watl.txt item: #5 of 115 id: cord-001521-l36f1gp7 author: None title: Oral and Poster Manuscripts date: 2011-04-08 words: 183853 flesch: 46 summary: The concept that swine are a mixing-vessel for the reassortment of influenza viruses and for the emergence of pandemic influenza viruses has been re-enforced by the emergence of the recent pandemic. This study was supported by Contract HHSN266200700005C from the National Institute of Allergy and Infectious Diseases, National Institutes of Pigs have been considered as hypothetical 'mixing vessels' facilitating the genesis of pandemic influenza viruses. keywords: age; analysis; animals; antibodies; antibody; antiviral; assay; associated; avian; b viruses; b ⁄; balb ⁄; binding; c virus; c ⁄; cases; cells; challenge; children; control; cross; culture; data; days; detection; disease; dk ⁄; dose; effect; ferrets; figure; following; gene; group; h1n1 influenza; h1n1 pandemic; h1n1 virus; h5n1 infection; h5n1 viruses; h9n2; health; high; hong; hours; human h1n1; human influenza; humans; immunity; infected; infections; influenza antigenic; influenza c; influenza epidemic; influenza infection; influenza influenza; influenza neuraminidase; influenza outbreaks; influenza pandemic; influenza patients; influenza research; influenza samples; influenza season; influenza strains; influenza surveillance; influenza transmission; influenza vaccination; influenza vaccine; influenza virus; isolates; kong ⁄; laboratory; laiv; lg ⁄; like; low; lung; mallard ⁄; mdck; method; mg ⁄; mice; model; mutation; nasal; new; non; novel; number; observed; origin influenza; oseltamivir; patients; pcr; period; pigs; population; positive; post; potential; potsdam ⁄; protection; protein; public; rate; research; resistance; respiratory; response; results; risk; rna; samples; school; seasonal; sensitivity; sequence; serum; severe; specific; specimens; studies; study; subjects; subtype influenza; sw ⁄; swine influenza; swine viruses; system; t ⁄; table; test; time; treatment; type virus; vaccines; values; virus gene; virus infection; virus isolation; virus ns1; virus replication; virus strains; virus titers; virus transmission; virus vaccine; virus ⁄; viruses; wave; years; ⁄ brisbane; ⁄ california; ⁄ genoa; ⁄ h1n1; ⁄ h3n2; ⁄ h5n1; ⁄ hk; ⁄ hok; ⁄ lee; ⁄ leningrad; ⁄ ml; ⁄ netherlands; ⁄ ns1; ⁄ panama; ⁄ pr8; ⁄ vietnam cache: cord-001521-l36f1gp7.txt plain text: cord-001521-l36f1gp7.txt item: #6 of 115 id: cord-002757-upwe0cpj author: Sullivan, Kathleen E. title: Emerging Infections and Pertinent Infections Related to Travel for Patients with Primary Immunodeficiencies date: 2017-08-07 words: 24227 flesch: 37 summary: Importantly, after a novel PIDD has been described, subsequent reports often reveal a wider variation in associated infections and cellular findings, often without clear genotype-phenotype correlations [320] [321] Human infection, called Cat Scratch Disease, is assumed to involve inoculation of Bartonella-infected flea feces into the skin during a cat scratch. keywords: associated; azole; bartonella; cases; cause; cell; children; chronic; clinical; cns; countries; days; deficiency; dengue; diagnosis; disease; epidemiology; fever; hiv; human; immune; immunodeficiency; immunoglobulin; individuals; infection; influenza; mandrillaris; patients; pcr; pidd; primary; resistance; review; risk; skin; species; susceptibility; symptoms; syndrome; therapy; tick; transmission; treatment; vaccination; vaccine; virus cache: cord-002757-upwe0cpj.txt plain text: cord-002757-upwe0cpj.txt item: #7 of 115 id: cord-003256-8plv9q8b author: Zhou, Xiaoqin title: Review of global sanitation development date: 2018-11-17 words: 10367 flesch: 37 summary: We used bibliometric analysis and word cluster analysis to evaluate sanitation research from 1992 to 2016 based on the Science Citation Index EXPANDED (SCI-EXPANDED) and Social Sciences Citation Index (SSCI) databases. Publication patterns We identified 18,449 publications related to sanitation research in the SCI-Expanded and SSCI databases between 1900 and 2016, and we found a continual growth trend, as shown in Fig. 1 . keywords: analysis; articles; composting; countries; et al; excreta; human; keywords; level; number; recovery; research; sanitation; social; technologies; toilet; urine; usa; water cache: cord-003256-8plv9q8b.txt plain text: cord-003256-8plv9q8b.txt item: #8 of 115 id: cord-003334-ion97n4b author: De Silva Senapathi, Upasama title: The In Ovo Delivery of CpG Oligonucleotides Protects against Infectious Bronchitis with the Recruitment of Immune Cells into the Respiratory Tract of Chickens date: 2018-11-15 words: 5831 flesch: 47 summary: Additionally, the authors saw a significant reduction in the IBV nuclear (N) gene mRNA expression in various embryonic tissues pre-treated with CpG ODNs, compared with the control, highlighting the value of CpG ODN treatment in IBV control. Thus, our objectives were to determine the protective effect of the in ovo delivery of CpG ODNs at ED 18 against IBV infection encountered post-hatch and, then, to investigate the mechanisms of protection. keywords: birds; cells; control; cpg; dpi; ibv; infected; odn; odns; ovo; pre cache: cord-003334-ion97n4b.txt plain text: cord-003334-ion97n4b.txt item: #9 of 115 id: cord-003738-el0wyu74 author: Zhang, Qingxiu title: The interleukin-4/PPARγ signaling axis promotes oligodendrocyte differentiation and remyelination after brain injury date: 2019-06-21 words: 10524 flesch: 45 summary: The percentages of IL-4Rα + O4 + cells were higher in the ipsilateral ischemic hemisphere (Fig 1C and 1D) , suggesting a potential direct effect of IL-4 on white matter cells. Frequency histograms revealed much greater reduction of axon diameters in the MCAO + vehicle group compared to the MCAO + IL-4 and sham groups, suggesting higher axonal degeneration in stroke mice without IL-4 treatment (Fig 5B) . keywords: brain; cells; data; differentiation; fig; il-4; ischemic; matter; mbp; mcao; mice; microglia; oligodendrocyte; opc; opcs; pparγ; remyelination; stroke; treatment; usa; white cache: cord-003738-el0wyu74.txt plain text: cord-003738-el0wyu74.txt item: #10 of 115 id: cord-003841-7uaj9hmx author: Desmonts de Lamache, D. title: Immuno-modulating properties of Tulathromycin in porcine monocyte-derived macrophages infected with porcine reproductive and respiratory syndrome virus date: 2019-08-23 words: 8002 flesch: 34 summary: Treatment with tulathromycin (1mg/mL) significantly reduced PRRSV cell necrosis at 12 hours (Fig 9) . However, due to its high antigenic variability and poorly understood immunopathogenesis, there is currently no effective vaccine or treatment to control PRRSV infection. keywords: anti; cells; effects; fig; infection; l929; macrophages; mdms; monocyte; porcine; production; prrsv; syndrome; tulathromycin; usa; virus cache: cord-003841-7uaj9hmx.txt plain text: cord-003841-7uaj9hmx.txt item: #11 of 115 id: cord-003898-y6zpvw84 author: Tan, Kai Sen title: RNA Sequencing of H3N2 Influenza Virus-Infected Human Nasal Epithelial Cells from Multiple Subjects Reveals Molecular Pathways Associated with Tissue Injury and Complications date: 2019-08-27 words: 7697 flesch: 39 summary: Hence, production of factors such as STAT1 [28] by the hNECs is also crucial in ensuring appropriate regulation of IFNγ-mediated expression of influenza response genes to modulate inflammation and to minimize damage. At later time points, the number of gene expression changes increased substantially, with upregulation of 704 and 1080 genes, and downregulation of 217 and 758 genes at 24 and 48 hpi, respectively. keywords: analysis; cells; changes; epithelium; expression; genes; hnecs; hpi; infection; influenza; nasal; responses; rnaseq; time; virus cache: cord-003898-y6zpvw84.txt plain text: cord-003898-y6zpvw84.txt item: #12 of 115 id: cord-006771-n1w56x2m author: Liu, Chien-Ying title: Apoptotic neutrophils undergoing secondary necrosis induce human lung epithelial cell detachment date: 2003-10-17 words: 4673 flesch: 27 summary: key: cord-006771-n1w56x2m authors: Liu, Chien-Ying; Liu, Yun-Hen; Lin, Shu-Min; Yu, Chih-Ten; Wang, Chun-Hua; Lin, Horng-Chyuan; Lin, Chien-Huang; Kuo, Han-Pin title: Apoptotic neutrophils undergoing secondary necrosis induce human lung epithelial cell detachment date: 2003-10-17 journal: J Biomed Sci DOI: 10.1007/bf02256327 sha: doc_id: 6771 cord_uid: n1w56x2m Clearance of apoptotic neutrophils by alveolar macrophages plays an important role in the resolution phase of lung inflammation. Granulocytes and mononuclear leukocytes on discontinuous density gradients of Ficoll-Hypaque Previous uptake of apoptotic neutrophils or ligation of integrin receptors downmodulates the ability of macrophages to ingest apoptotic neutrophils Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF A receptor for phosphatidylserine-specific clearance of apoptotic cells Activation of MMP-9 by neutrophil elastase in an in vivo model of acute lung injury Apoptotic hepatocytes become insoluble in detergents and chaotropic agents as a result of transglutaminase action A comparison of alpha 1-proteinase inhibitor me-thoxysuccinyI-Ala-Ala-Pro-Val-chloromethylketone and specific beta-lactam inhibitors in an acute model of human polymorphonuclear leukocyte elastase-induced tung hemorrhage in the hamster Dransfield I. Molecular characterization of the surface of apoptotic neutrophils: Implications for functional downregulation and recognition by phagocytes Granulocyte apoptosis and its role in the resolution and control of lung inflammation Impaired alveolar macrophage function in smoke inhalation injury Neutrophil adherence to lung epithelial cells induce interleukin-8 release Differential patterns of apoptosis in resolving and nonresolving bacterial pneumonia Caspase-mediated proteolysis and activation of protein kinase Cdelta plays a central role in neutrophil apoptosis Constitutive apoptosis in human neutrophils requires synergy between calpains and the proteasome downstream of caspases Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis Lipopolysaccharide enhances substance Pmediated neutrophil adherence to epithelial cells and cytokine release Endogenous nitric oxide inhibits neutrophil adherence to lung epithelial cells to modulate interleukin-8 release Degradation of type IV (basement membrane) collagen by a proteinase isolated from human polymorphonuclear leukocyte granules Neutrophil apoptosis in the acute respiratory distress syndrome Effects of Pseudomonas aeruginosa rhamnolipids on human monocyte-derived macrophages Inhibition of macrophage phagocytosis by Pseudomonas aeruginosa rhamnolipids in vitro and in vivo In vivo suppression of immune complex-induced alveolitis by secretory leukopmteinase inhibitor and tissue inhibitor of metalloproteinases 2 Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial ceil line Direct cytotoxicity of polymorphonuclear leukocyte granule proteins to human lung-derived cells and endothelial cells The cell biology ofleukocyte-mediated proteolysis Mechanisms of neutrophil damage to human alveolar extracellular matrix: The role of serine and metalloproteases Alveolar macrophages of children suffering from recurrent infections of respiratory tract are less efficient in eliminating apoptotic neutrophils CD18 adhesion blockade decreases bacterial clearance and neutrophil recruitment after intrapulmonary E. coli, but not after S. aureu~ Effects of cystic fibrosis airway secretions on rat lung: Role of neutrophil elastase Proinflammatory cytokines potentiate thrombospondin-mediated phagocytosis of neutrophils undergoing apoptosis Cathepsin G activates protease-activated receptor-4 in human platelets Vitronectin receptor-mediated phagocytosis of ceils undergoing apoptosis Glomerular mesangial cells and inflammatory macrophages ingest neutrophils undergoing apoptosis Phagocytosis of aged human neutrophils by macrophages is mediated by a novel 'charge-sensitive' recognition mechanism Macrophage phagocytosis of aging neutrophils in inflammation. keywords: a549; annexin; apoptosis; cells; detachment; elastase; fig; human; lung; medium; neutrophils; usa cache: cord-006771-n1w56x2m.txt plain text: cord-006771-n1w56x2m.txt item: #13 of 115 id: cord-006876-v2m5l5wz author: None title: Neurocritical Care Society 14(th) Annual Meeting date: 2016-08-11 words: 59827 flesch: 46 summary: However, the trend was not uniform -48% patients had no correlation between rSO2 and CPP, 29% showed a positive correlation and 23% showed a negative correlation. Major reasons for satisfaction included: physician response to emergencies, physician -nurse communication, and patient outcome. keywords: acute; admission; analysis; arrest; asah; associated; baseline; blood; brain; brain injury; cardiac; care; care patients; care unit; case; center; cerebral; cohort; complications; data; days; death; developed; discharge; dose; duration; eeg; following; gcs; group; hemorrhage; hospital; hours; ich; ich patients; icp; icu; impact; injury; intensive; intracranial; management; mean; median; medical; model; monitoring; months; mortality; neurocritical; neurological; new; non; onset; outcome; patients; pcc; post; pressure; primary; rate; results; review; sah; sah patients; score; seizures; status; studies; study; subarachnoid; tbi; therapy; time; total; treated; treatment; unit; use; years cache: cord-006876-v2m5l5wz.txt plain text: cord-006876-v2m5l5wz.txt item: #14 of 115 id: cord-007383-5yb3dxse author: Kang, Jun-Gu title: Vaccination with single plasmid DNA encoding IL-12 and antigens of severe fever with thrombocytopenia syndrome virus elicits complete protection in IFNAR knockout mice date: 2020-03-20 words: 5381 flesch: 42 summary: We examined whether it could provide protective immunity against lethal SFTSV infection in IFNAR KO mice. Vaccination of pSFTSV-IL12 provided complete protection of IFNAR KO mice upon lethal SFTSV challenge, whereas immunization with pSFTSV elicits only partial protection, indicating that antigen-specific cellular immune responses enhanced by co-expression of IL-12 could play a significant role in protection against lethal SFTSV infection. keywords: antigen; cells; dna; fig; infection; lethal; mice; protection; protein; sftsv; usa; vaccine cache: cord-007383-5yb3dxse.txt plain text: cord-007383-5yb3dxse.txt item: #15 of 115 id: cord-007425-l9c1x7tb author: Klomp, Richard W. title: CDC’s Multiple Approaches to Safeguard the Health, Safety, and Resilience of Ebola Responders date: 2019-12-10 words: 4220 flesch: 39 summary: The CDC added this new screening to pre-deployment safety and resilience briefings, classroom resilience training, and post-deployment outreach initiatives that have been a part of CDC deployments since 2005. Several years ago, CDC resilience experts conducted an environmental scan to see what other federal agencies did to protect workers placed in inhospitable or potentially dangerous environments. keywords: cdc; deployers; deployment; field; health; individuals; ramp; resilience; safety; team; training cache: cord-007425-l9c1x7tb.txt plain text: cord-007425-l9c1x7tb.txt item: #16 of 115 id: cord-008764-j9qmw4zy author: None title: Chapter 1 The need for chemotherapy and prophylaxis against viral diseases date: 2008-05-29 words: 6405 flesch: 43 summary: Problems Easy Accessible Incidence with vaccine diagnosis virus enzyme aAlthough not included in the six target diseases, there is a relationship between this programme and the prevention and control of diseases such as yellow fever, hepatitis, rubella and mumps. It briefly mentions clinical diseases and syndromes such as influenza, respiratory tract infections, hepatitis, and arbovirus infections resulting from virus infections. keywords: cost; countries; diseases; herpes; infections; influenza; measles; rubella; usa; vaccines; viruses cache: cord-008764-j9qmw4zy.txt plain text: cord-008764-j9qmw4zy.txt item: #17 of 115 id: cord-009439-wvlczk62 author: Park, Hyun-Jun title: The essential role of fructose-1,6-bisphosphatase 2 enzyme in thermal homeostasis upon cold stress date: 2020-03-16 words: 6207 flesch: 42 summary: However, with primary cultured myoblasts from the WT and Fbp2 KO mouse muscles, cellular oxygen consumption rates were significantly decreased in KO mouse myoblasts (Fig. 4g) , which was consistent with the decreased whole-body V O2 and V CO2 rates in the indirect calorimetry study (Fig. 1h, j) . To address the mechanism underlying the reduced glycogen content in KO mouse muscle, we next tested whether Fbp2 plays a role in intramuscular glyconeogenesis. keywords: body; cold; fbp2; fbp2 ko; fig; glucose; glycogen; glyconeogenesis; ko mice; metabolism; mice; muscle; usa cache: cord-009439-wvlczk62.txt plain text: cord-009439-wvlczk62.txt item: #18 of 115 id: cord-012826-72mz834w author: Xu, Zhen-dong title: Propofol affects mouse embryonic fibroblast survival and proliferation in vitro via ATG5- and calcium-dependent regulation of autophagy date: 2019-10-23 words: 4798 flesch: 43 summary: Propofol at clinical concentrations (10 µM) significantly induces the release of more Ca 2+ from the ER into the cytosol in ATG5 −/− cells than in WT cells via the activation of inositol-1,4,5-trisphosphate receptor (InsP 3 R) and/or ryanodine receptor (RyR) calcium channels, favoring cell survival and proliferation The role of autophagy during the early neonatal starvation period Atg5 is essential for the development and survival of innate lymphocytes Involvement of autophagy in NK cell development and function Atg5 and Bak play important roles in the crosstalk between apoptosis and autophagy induced by influx of extracellular calcium Calcium homeostasis and ER stress in control of autophagy in cancer cells Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB *P < 0.05, **P < 0.01, or ***P < 0.001, respectively General anesthetics and autophagy ZD Xu et al. (200 µM) decreased the total cell numbers more significantly in ATG5 −/− cells than in WT cells (Fig. 2a-c) . keywords: atg5; autophagy; cells; concentrations; effects; propofol; survival; −/− cache: cord-012826-72mz834w.txt plain text: cord-012826-72mz834w.txt item: #19 of 115 id: cord-012909-o6t2srim author: Chaudhari, Jayeshbhai title: Host Transcriptional Response to Persistent Infection with a Live-Attenuated Porcine Reproductive and Respiratory Syndrome Virus Strain date: 2020-07-28 words: 9329 flesch: 38 summary: A portion of freshly isolated PBMCs were used for measurement of T cell responses while the rest of PBMCs were cryopreserved for future analysis. Briefly two replicates of 250,000 PBMCs or ILN cells freshly collected from each pig were plated into two wells of a 96-well plate with PVDF membrane that were coated with anti-porcine IFN-γ antibody. keywords: activation; apoptosis; cells; con90; expression; figure; genes; ifn; iln; infection; pigs; porcine; prrsv; rna; study; syndrome; tissue; usa; viral; virus cache: cord-012909-o6t2srim.txt plain text: cord-012909-o6t2srim.txt item: #20 of 115 id: cord-013178-li1x1m25 author: Hung, Ling-Chu title: The Monoclonal Antibody Recognized the Open Reading Frame Protein in Porcine Circovirus Type 2-Infected Peripheral Blood Mononuclear Cells date: 2020-08-29 words: 9845 flesch: 55 summary: This study found non-vaccinated suckers had the highest of PCV2 proteins in blood at one week of age. The data show that 3–5% of PBMCs were positive for ORF3 protein or p53 protein. keywords: anti; capsid; circovirus; figure; igg; mab; orf3; orf3 protein; p53; pbmcs; pcv2; peptide; porcine; protein; study; type cache: cord-013178-li1x1m25.txt plain text: cord-013178-li1x1m25.txt item: #21 of 115 id: cord-013325-8lds7nti author: Ecker, Jeffrey W. title: High-Yield Expression and Purification of Recombinant Influenza Virus Proteins from Stably-Transfected Mammalian Cell Lines date: 2020-08-21 words: 9423 flesch: 36 summary: Immunohorizons Beta 2-microglobulin-deficient mice can be protected against influenza A infection by vaccination with vaccinia-influenza recombinants expressing hemagglutinin and neuraminidase Defining B cell immunodominance to viruses Recombinant hemagglutinin influenza vaccine provides broader spectrum protection Towards a universal influenza vaccine: Different approaches for one goal Prospects and Challenges in the Development of Universal Influenza Vaccines Production of Therapeutic Enzymes by Lentivirus Transgenesis Recombinant protein production from stable mammalian cell lines and pools Recombinant protein vaccines produced in insect cells Non-conventional expression systems for the production of vaccine proteins and immunotherapeutic molecules. HA and NA recombinant proteins were also expressed through the generation of stable transfected cells ( Figure 2 ). keywords: activity; binding; cells; expression; figure; fisher; h1n1; influenza; lines; production; proteins; recombinant; rha; scientific; thermo; usa; vaccine; virus cache: cord-013325-8lds7nti.txt plain text: cord-013325-8lds7nti.txt item: #22 of 115 id: cord-013601-y8pc4qfc author: Zhou, Bo-ya title: Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization date: 2020-04-23 words: 6163 flesch: 42 summary: Sorafenib, a potent TKI targeting VEGFR2 and PDGFRβ, has been shown to effectively inhibit keloid cell proliferation, migration, invasion, and collagen production [5] . It has been shown that the keloid mechanism involves multiple signaling pathways, such as VEGF, PDGF, FGF, and TGF-β, but there has been no report on a drug that could target more than three growth factors among the studies on drugs targeting keloid cell behavior [5, 14, 15] . keywords: assay; cell; drug; fibroblasts; fig; growth; keloid; kfs; migration; nintedanib; proliferation; protein; signaling; treatment cache: cord-013601-y8pc4qfc.txt plain text: cord-013601-y8pc4qfc.txt item: #23 of 115 id: cord-015391-zf3bx8i7 author: None title: President’s Plenary Session date: 2012-12-30 words: 384 flesch: 40 summary: Poster Session III -Douglas Pavilion S-089 Infl ammation Provoking a Cytokine Response and Disrupting the Epithelial Barrier Is Mitigated with Dexamethasone: A Possible Mechanism of Premature Cervical Remodeling and Preterm Birth Immune Adaptations of Pregnancy as Risk Factors of Gestational UTI Appropriate for Gestational Age-Preterm Neonates Born to Mothers with Moderate, but Not Mild or Severe, Intensity of Histologic Chorioamnionitis, Funisitis, and Intraamniotic Infl ammation without Microbial Invasion of Amniotic Cavity Have a Lower Rate of RDS. Than, Edgar Hernandez-Andrade, Zeynep Alpay Savasan, Adi L Tarca, Gaurav Bhatti, Zhong Dong, and Sonia S Hassan. keywords: ammation; infl; usa cache: cord-015391-zf3bx8i7.txt plain text: cord-015391-zf3bx8i7.txt item: #24 of 115 id: cord-015394-uj7fe5y6 author: None title: Scientific Abstracts date: 2008-12-23 words: 242809 flesch: 48 summary: The highest level of -tubulin acetylation (2.5-fold) was observed with Vinblastine at 10-fold IC 50 after 48 h. Exposure to Microtubule interacting agents and TSA resulted in increased cell surface expression of Ep-CAM in a time and dose dependent manner. Finally, we elucidated a link between the RA and TGF-pathways by assessing the impact of RA treatment of TGF-3 expression, demonstrating that TGF-3 template decreased to levels comparable to myometrial cell expression (0.84±0.12 fold). keywords: acid; activation; activity; addition; administration; adult; aea; age; aim; analysis; animals; anova; anti; antibodies; antibody; apoptosis; arteries; artery; assay; associated; association; background; baseline; binding; birth; blood; blood cells; blot; bmi; body; brain; cancer; cancer cells; cases; cells; center; cervix; cesarean; changes; clinical; collagen; concentrations; conclusions; conditions; contractions; contrast; contribute; control; control cells; control group; correlation; cortisol; crf; culture; cycle; cytokines; data; day; days; decidua; decrease; delivery; design; development; differences; differentiation; disease; dna; dose; effect; elisa; endometriosis; endometrium; endothelial; eoc cells; epithelial; estradiol; estrogen; evidence; explants; exposure; expression; expression levels; factor; fat; female; fetal; fetuses; findings; flow; fluid; fold; following; free; function; gene; gestation; glucose; gnrh; group; growth; gynecology; hcg; high; hormone; hospital; hours; human; hypertension; hypothesis; hypoxia; il-6; il-8; immune; immunohistochemistry; implantation; increase; induction; infection; inflammation; inhibitor; insulin; introduction; invasion; iugr; ivf; kinase; labor; leptin; levels; lps; male; maternal; mean; mechanisms; media; medical; medicine; medium; membranes; menstrual; methods; mice; min; model; mouse; mrna expression; mrna levels; muscle cells; myometrial; n=6; neonatal; new; non; normal; novel; nuclear; number; obesity; objective; obstetrics; offspring; onset; oocytes; outcome; ovarian; oxygen; p<0.001; p<0.05; pathway; patients; pattern; pcos; pcr; period; phase; phosphorylation; placental; placental cells; plasma; play; population; positive; post; potential; preeclampsia; pregnancies; pregnancy; pregnant; presence; present; pressure; preterm; primary; production; progesterone; proliferation; protein expression; protein levels; proteins; range; rate; rats; receptor; receptor expression; reduced; regulation; relative; release; reproductive; response; restriction; results; risk; role; samples; secretion; sections; serum; sheep; signaling; smooth; specific; staining; stress; studies; study; study group; subjects; syndrome; system; t cells; term; test; time; tissue; tnf; total; treatment; trimester; trophoblast cells; tumor; type; university; usa; uterine; uterus; vascular; vegf; vehicle; vitro; vivo; weeks; weight; western; women; years cache: cord-015394-uj7fe5y6.txt plain text: cord-015394-uj7fe5y6.txt item: #25 of 115 id: cord-018839-yfaji9cv author: Kim, Yong-kyun title: Disaster Theory date: 2017-07-11 words: 17979 flesch: 33 summary: In late 1970, more than 100 federal organizations related to civil engineering and defense had fragmented responsibilities for hazard mitigation and disaster response, resulting in no coordinating organization taking the full responsibility for the entire phase of disaster management. The plan incorporates all aspects of disaster management in any given area, and it guides the roles and responsibilities of all related agencies for disaster response, depending on the size and complexity of a disaster. keywords: accident; act; agencies; agency; crisis; damage; disaster; disaster management; disaster prevention; disaster response; disaster risk; emergency; emergency management; federal; fire; government; korea; level; management system; national; organizations; plan; public; risk; risk management; safety; state; support; system; theory cache: cord-018839-yfaji9cv.txt plain text: cord-018839-yfaji9cv.txt item: #26 of 115 id: cord-019032-vdiaexbw author: Kshetri, Nir title: China date: 2020 words: 19007 flesch: 63 summary: Mainland China's busiest port in 2012 was Ningbo-Zhoushan (handling 744Á0m. tonnes of cargo), followed by Shanghai (637Á4m. tonnes), Tianjin (477Á0 tonnes), Guangzhou (Canton) (435Á2m. tonnes) and Qingdao (406Á9m. tonnes). Population of largest cities in 2010: Shanghai, 20Á22m.; Beijing (Peking), 16Á45m.; Shenzhen, 10Á36m.; Guangzhou (Canton), 9Á70m.; Tianjin, 9Á29m.; Dongguan, 7Á27m.; Wuhan, 6Á84m.; Foshan, 6Á77m.; Chengdu, 6Á32m.; Chongqing, 6Á26m.; Nanjing, 5Á83m.; Shenyang, 5Á72m.; Xian, 5Á21m.; Hangzhou, 5Á16m.; Haerbin, 4Á60m.; Suzhou, 4Á08m.; Dalian, 3Á90m.; Zhengzhou, 3Á68m.; Shantou, 3Á64m.; Jinan, 3Á53m.; Qingdao, 3Á52m.; Changchun, 3Á41m.; Kunming, 3Á28m.; Changsha, 3Á19m.; Taiyuan, 3Á15m.; Xiamen, 3Á12m.; Hefei, 3Á10m.; Urumqi (Wulumuqi), 2Á85m.; Fuzhou, 2Á82m.; Shijiazhuang, 2Á77m.; Wuxi, 2Á76m.; Zhongshan, 2Á74m.; Wenzhou, 2Á69m.; Nanning, 2Á66m.; Ningbo, 2Á58m.; Guiyang, 2Á52m.; Lanzhou, 2Á44m.; Zibo, 2Á26m.; Changzhou, 2Á26m.; Nanchang, 2Á22m.; Xuzhou, 2Á21m.; Tangshan, 2Á13m. China has 56 ethnic groups. keywords: china; chinese; council; country; economic; economy; exports; foreign; gdp; government; growth; hong; hong kong; international; jan; july; kong; mainland; march; national; new; number; party; people; population; president; production; state; taiwan; tonnes; total; trade; usa; world; year; yuan cache: cord-019032-vdiaexbw.txt plain text: cord-019032-vdiaexbw.txt item: #27 of 115 id: cord-020010-q58x6xb0 author: None title: 19th ICAR Abstracts: date: 2006-03-13 words: 46881 flesch: 40 summary: Although anti-inflammatory agents are not very active in vitro, it is thought that they might be efficacious in reducing any deleterious inflammatory response associated with virus infections such as SARS infections in humans. Although only BTCRB and BDCRB were inhibitors of the ATPase activity, two other compounds, dBDCRB and Cl4RB, inhibited virus replication in a plaque-reduction assay, thus indicating that those have a different mode of action. keywords: acid; action; activity; agents; animals; antiviral; assay; cdv; cells; combination; compounds; concentrations; containing; control; culture; days; department; derivatives; development; disease; dna; dose; drug; effect; efficacy; gene; hcv; hiv; human; infection; influenza; influenza virus; inhibited; inhibition; inhibitors; institute; mice; model; molecular; mutations; new; novel; nucleoside; polymerase; potent; potential; presence; present; properties; protein; reduction; replication; research; resistance; results; rna; specific; strain; structure; studies; study; synthesis; system; target; tested; therapeutic; therapy; treatment; type; university; usa; virus; virus infection; virus replication; viruses; vitro; vivo cache: cord-020010-q58x6xb0.txt plain text: cord-020010-q58x6xb0.txt item: #28 of 115 id: cord-023049-fio7cjj5 author: None title: 2017 Peripheral Nerve Society Meeting July 8–12, 2017 Sitges, Barcelona, Spain date: 2017-06-22 words: 145714 flesch: 46 summary: We compared the median SNAP with radial SNAP measured antidromically at digit 1 in GBS patients whose nerve conduction study showed the sural-sparing pattern. The aim of the present investigation is to summarize the current knowledge on sweating disturbances in GBS patients. keywords: 1,2; activity; acute; addition; age; aim; amyloid; analysis; anti; antibodies; antibody; associated; axonal; axons; barré; baseline; biopsy; blood; cases; cause; cells; center; changes; charcot; children; chronic; cidp patients; cmt patients; cmt1a; cohort; conduction study; control patients; controls; course; criteria; data; days; degeneration; demyelinating; department; development; diabetic; diagnosis; differences; disability; disease; dominant; dose; effect; examination; expression; f 1; family; findings; following; foot; france; function; g 1; gbs patients; gene; group; guillain; healthy; hospital; human; igg; impairment; improvement; increase; inflammatory; injury; institute; intravenous; involvement; ivig; j 1; k 1; levels; limbs; loss; mag; marie; mean; measures; median; medical; medicine; mice; model; months; motor; motor nerve; mouse; mri; muscle; mutations; ncs; negative; nerve; nerve conduction; nerve fibers; nerve injury; nerve regeneration; neurological; neurology; neurons; neuropathies; neuropathy; new; nf155; non; normal; novel; number; onset; outcome; pain; participants; patients; phenotype; placebo; pmp22; polyneuropathy; positive; potential; present; progression; protein; range; reduced; report; respectively; response; results; risk; role; scale; schwann; score; sensory; sequencing; serum; severe; severity; skin; strength; studies; study; subjects; sural; symptoms; syndrome; system; test; testing; therapeutic; therapy; time; tissue; tooth; total; treatment; ttr; type; ulnar; university; upper; usa; variants; weakness; weeks; y 1; years cache: cord-023049-fio7cjj5.txt plain text: cord-023049-fio7cjj5.txt item: #29 of 115 id: cord-023211-kt5gt26t author: None title: Poster Session Abstracts date: 2007-08-29 words: 221712 flesch: 48 summary: Understanding how its modulation modifies transepithelial transport and inflammation in CF versus non CF cells should give new therapeutic clues to reduce exaggerated inflammation and improve fluid secretion in CF patients. This finding indicates that CFTR potentiators have a wide efficacy on many class III mutants and therefore may represent a promising therapeutic strategy for a significant number of CF patients. keywords: acid; addition; adult cf; adult patients; adults; aeruginosa; age; aim; airway; airway cells; amiloride; analysis; antibiotic; asl; assay; atp; background; bacterial; baseline; binding; biofilm; blood; bmi; cells; cf airways; cf care; cf center; cf clinic; cf foundation; cf gene; cf group; cf lung; cf mouse; cf nbs; cf patients; cf research; cf sputum; cff; cfrd; cftr; cftr activation; cftr activity; cftr cells; cftr channel; cftr chloride; cftr expression; cftr function; cftr gene; cftr inhibitor; cftr mice; cftr mutations; cftr promoter; cftr protein; cftr trafficking; changes; channel; children; chronic; clearance; clinical; concentrations; conclusion; conditions; contrast; control; cultures; current; cystic; daily; data; day; days; decline; decreased; dependent; diabetes; differences; disease; dna; domain; dose; drug; effect; enac; epithelial; exacerbation; experiments; exposure; expressing; f508del; factors; family; fev1; fibrosis patients; findings; fold; forskolin; functional; genes; glands; group; growth; health; hospital; hours; human; human cf; il-8; improvement; increase; individuals; infants; infection; inflammation; inflammatory; information; inhibited; inhibition; isolates; levels; life; low; lung cells; lung disease; lung function; lungs; mean; measure; mechanism; median; medical; membrane; methods; mice; model; months; mrsa; mucus; mutant; nasal; nbd1; neutrophil; new; non; normal; novel; number; observed; order; pancreatic; parents; pathway; patients age; pcr; pediatric; period; plasma; population; positive; post; potential; presence; present; production; proteins; pseudomonas; pulmonary; quality; range; rate; regulation; research; respiratory; response; results; risk; role; samples; scores; screening; secretion; sensitive; serum; specific; status; stimulation; strains; studies; study; study patients; subjects; support; surface; symptoms; system; test; testing; therapeutic; therapies; therapy; time; tobramycin; total; transport; treatment; type cftr; university; usa; use; values; vitamin; vitro; vivo; volume; weight; wt cells; wt cftr; years; ∆f508 cftr cache: cord-023211-kt5gt26t.txt plain text: cord-023211-kt5gt26t.txt item: #30 of 115 id: cord-023442-4vzwc2d2 author: None title: Proceedings of SCANNING 94/SEEMS 94 Charleston, South Carolina, USA date: 2006-12-05 words: 55600 flesch: 45 summary: Applications include both thin-film and bulk x-ray microanalysis and examples of contrast in backscattered electron images obtained in the SEM. The effects of adjusting the Wehnelt-to-tip distance vary for different electron microscope systems. keywords: addition; analysis; associated; atomic; backscattered; carlo; cells; chemical; comparison; composition; conditions; confocal; contrast; cross; crystal; data; detection; detector; developed; development; distribution; drying; effects; electron; electron beam; electron microscopy; energy; field; fig; figure; form; formation; glass; image; imaging; laser; light; lines; material; measurement; method; microscope; milk; model; monte; new; number; particles; pattern; phase; point; preparation; probe; process; program; ray; region; resolution; results; sample; scanning; scattering; sections; sem; signal; silicon; simulation; size; specific; specimen; structures; studies; study; substrate; supplement; surface; system; techniques; temperature; time; tissue; transmission electron; type; use; vol; water; work cache: cord-023442-4vzwc2d2.txt plain text: cord-023442-4vzwc2d2.txt item: #31 of 115 id: cord-023837-kenstpja author: None title: China date: 2019 words: 17769 flesch: 62 summary: Mainland China's busiest port in 2012 was Ningbo-Zhoushan (handling 744·0m. tonnes of cargo), followed by Shanghai (637·4m. tonnes), Tianjin (477·0 tonnes), Guangzhou (Canton) (435·2m. tonnes) and Qingdao (406·9m. tonnes). Mandarin in one form or another is spoken by 885m. people in China, or around 70% of the population of mainland China. keywords: china; chinese; economic; economy; foreign; gdp; government; growth; hong; hong kong; international; jan; july; kong; mainland; national; number; party; people; population; power; production; rate; republic; schools; state; taiwan; tonnes; total; usa; world; year; yuan cache: cord-023837-kenstpja.txt plain text: cord-023837-kenstpja.txt item: #32 of 115 id: cord-024047-wg7hew1b author: Lennox, Angela M. title: Equipment for Exotic Mammal and Reptile Diagnostics and Surgery date: 2006-06-29 words: 2014 flesch: 40 summary: Maintenance of core body heat during surgery is critical, especially in smaller exotic patients. Blood losses acceptable in larger species are rapidly fatal in small exotic patients. keywords: blood; endoscopy; equipment; mammals; medicine; patients cache: cord-024047-wg7hew1b.txt plain text: cord-024047-wg7hew1b.txt item: #33 of 115 id: cord-025009-01hsn3us author: Poitiers, Niclas Frederic title: Institutionelle Aspekte einer neuen Handelsordnung date: 2020-05-20 words: 1956 flesch: 51 summary: Daher wird die Bereitschaft dieser Länder, eine Koalition mit der EU gegen die Interessen der USA einzugehen, nur sehr begrenzt sein. Insbesondere die Level Playing Field-Klauseln werden von den Vertragspartnern der EU teilweise als Bevormundung und Protektionismus wahrgenommen. keywords: als; auch; china; dass; den; der; des; die; eine; für; ist; mit; nicht; sich; und; usa; von; werden; wto cache: cord-025009-01hsn3us.txt plain text: cord-025009-01hsn3us.txt item: #34 of 115 id: cord-025010-3k17eyqx author: Diekmann, Berend title: Globale Handelsordnung — mit den oder ohne die USA? date: 2020-05-20 words: 1719 flesch: 46 summary: Damit gerät allerdings auch der originäre Anspruch der Welthandelsordnung ins Wanken: die Nicht-Diskriminierung auf Basis der Gegenseitigkeit. Vor dem Handelskonfl ikt mit China importierten die USA Medizinprodukte im Wert von ca China war unter anderem Hauptlieferant für Schutzausrüstung, die EU lieferte in erster Linie medizinisches Gerät wie z. B. Computertomografen oder Patientenmonitore. keywords: als; auch; auf; china; das; den; der; des; die; ein; ist; mit; nicht; sich; sie; und; usa; von; wto cache: cord-025010-3k17eyqx.txt plain text: cord-025010-3k17eyqx.txt item: #35 of 115 id: cord-026579-k3w8h961 author: Carr, Paul R. title: Shooting Yourself First in the Foot, then in the Head: Normative Democracy Is Suffocating, and then the Coronavirus Came to Light date: 2020-06-10 words: 8712 flesch: 41 summary: I highlight three central arguments: (1) Social media, and, consequently, citizen engagement are becoming a significant filter that can potentially re-imagine the political, economic, and social worlds, which increasingly bleed over to how we might develop and engage with ‘democracy’; to this end, I introduce a brief case study on the nefarious interpretation of the killing of Jamal Khashoggi in 2018 to underscore the tension points in normative democracy; (2) Capitalism, or neoliberalism, needs to be more fully exposed, interrogated, and confronted if ‘normative, representative, hegemonic, electoral democracy’ is to be re-considered, re-imagined, and re-invented; the perpetuation of social inequalities lays bare the frailty of normative democratic institutions; (3) Covid-19 has exposed the fault lines and fissures of normative democracy, illustrating here the ‘common sense’ ways that power imbalances are sustained, which leaves little room for social solidarity; I present herein the case of the economic/labor dynamic in Quebec during the coronavirus. Social media is an exemplary feature of this new environment and can help us draw out the fundamental question if greater media, communication, and online involvement can lead to more robust, critical democratic forms of citizen participation. keywords: care; carr; case; covid-19; democracy; education; engagement; health; issues; media; movements; news; pandemic; people; time; usa; world cache: cord-026579-k3w8h961.txt plain text: cord-026579-k3w8h961.txt item: #36 of 115 id: cord-028341-93e30n3n author: Bünte, Claudia title: China und die Wirtschaft: Der Riese erwacht nicht, er ist längst auf der Überholspur date: 2020-06-26 words: 8854 flesch: 58 summary: Um die Innovationskraft verstehen und richtig einordnen zu können, die gerade bei KI von China ausgeht und weiter ausgehen wird, zeigt dieses Kapitel, wie sich China im Um die Innovationskraft verstehen und richtig einordnen zu können, die gerade bei KI von China ausgeht und weiter ausgehen wird, zeigt dieses Kapitel, wie sich China im keywords: 2017; aber; als; auch; auf; aus; bei; bereits; bis; china; chinesischen; das; dass; daten; dem; den; der; des; die; diese; ein; einer; entwicklung; für; global; haben; hat; hier; innen; ist; jahren; land; man; mehr; mit; nach; nicht; noch; nur; oder; plan; sehr; sein; sich; sie; sind; soll; und; unternehmen; usa; von; vor; war; weiter; welt; wenn; werden; westen; wie; wird; world; zeigt; zum; zur; über cache: cord-028341-93e30n3n.txt plain text: cord-028341-93e30n3n.txt item: #37 of 115 id: cord-029201-hkq7wti5 author: Haukkala, Hiski title: Nonpolar Europe? Examining the causes and drivers behind the decline of ordering agents in Europe date: 2020-07-15 words: 8077 flesch: 48 summary: Taking its cue from IR debates about the effects of polarity on international order, the article develops conceptual tools and an analytical narrative concerning Europe during the post-Cold War era. Taking its cue from International Relations (IR) debates about the effects of polarity (the number of Great Powers) on the evolution of international order (for a chronological lineage, see Waltz 1979; Kegley and Raymond 1994; keywords: europe; european; international; nonpolarity; order; ordering; politics; power; role; russia; usa; world cache: cord-029201-hkq7wti5.txt plain text: cord-029201-hkq7wti5.txt item: #38 of 115 id: cord-031907-ilhr3iu5 author: None title: ISEV2020 Abstract Book date: 2020-07-15 words: 201435 flesch: 40 summary: Normal pancreas cells (hTERT-HPNE and HPDE-H6c7) were co-cultured with cancer cell EVs for 24-48 hours. Before EV isolation cells were kept for 24 h either under normoxia or hypoxia (1% oxygen). keywords: ability; activation; activity; ad evs; addition; aim; analysis; analysis methods; anti; approach; assay; associated; bacterial evs; biological; biomarkers; blood; blood cells; blood evs; blot; bone; brain; breast; breast cancer; cancer cells; cancer evs; cancer introduction; cancer patients; cd63; cd81; cd9; cell communication; cell culture; cell evs; cell exosomes; cell function; cell lines; cell proliferation; cell surface; cell types; cells; cells introduction; changes; characterization; chromatography; composition; concentration; conclusion; conditions; content; control; control evs; cultured; current; cytometry; data; delivery; density; detection; development; diagnosis; differential; disease; distribution; dna; drug; effect; electron; endothelial; enrichment; epithelial; ev analysis; ev cargo; ev evs; ev isolation; ev markers; ev numbers; ev preparations; ev production; ev protein; ev release; ev research; ev rna; ev samples; ev subpopulations; ev surface; ev treatment; ev uptake; evs; exclusion; exosomal; exosomes; experiments; expression; expression analysis; extracellular; factors; findings; flow; fluorescent; fluorescent evs; fold; formation; fractions; free; function; funding; gene; group; growth; host cells; human; human evs; imaging; immune; increase; inflammation; inflammatory; introduction; isolated; isolation methods; key; large; levels; lipid; lung; macrophages; mass; mechanisms; media; medium; membrane; membrane vesicles; mesenchymal; metastasis; methods; mice; microscopy; migration; milk evs; mirna; model; molecular; molecules; mouse; msc evs; mscs; nanoparticle; national; neuronal; neurons; new; non; normal; novel; nta; number; particles; pathway; patients; plasma evs; plasma samples; platelet; platform; play; positive; positive evs; post; potential; presence; present; primary; process; production; profile; profiling; progression; proliferation; properties; prostate; prostate cancer; protein; protein cargo; protein expression; protein markers; proteomic; purification; purity; range; recipient cells; research; resistance; response; results; rna; rnas; role; samples; sec; secretion; sequencing; serum; sevs; signalling; single; size; small evs; specific; specific evs; spectrometry; stem cells; stromal cells; studies; study; summary; surface; system; target cells; targets; tau; techniques; tested; therapeutic; therapy; time; tissue; total; total evs; tracking; transfer; transmission; treatment; tumour cells; ultracentrifugation; university; uptake; urinary evs; urine; usa; usa introduction; use; vesicles; vesicles introduction; vitro; vivo; work cache: cord-031907-ilhr3iu5.txt plain text: cord-031907-ilhr3iu5.txt item: #39 of 115 id: cord-033146-2v1kuq50 author: Boylan, Brandon M. title: US–China Relations: Nationalism, the Trade War, and COVID-19 date: 2020-10-04 words: 7902 flesch: 44 summary: Trump Accuses China of 'Raping' US with Unfair Trade Policy China Falling Further behind US Trade Deal Energy Targets, Even as Crude Oil Imports Soar to Record Volumes Chinese Nationalism Under Xi Jinping Revisited The Scandal of Trump's China Policy. The United States in Historical and Comparative Perspective American Exceptionalism: A Double-edged Sword Trump Imposes Tariffs on Solar Panels and Washing Machines in First Major Trade Action The Thucydides Trap as an Alternative Explanation for the US-China Trade War Trump Administration Cracks Down on Giant Chinese Tech Firm, Escalating Clash with Beijing: The President Also Signed an Executive Order to Protect U.S. Networks from Foreign Espionage, a Move That Appears to Target China The Surprisingly Swift Decline of US Manufacturing Employment Neo-internationalism and China's Diplomacy Trump Proclamation Bars Entry of Certain Chinese Students. keywords: administration; china; chinese; energy; foreign; global; leaders; nationalism; oil; political; president; relations; state; support; trade; trade war; trump; usa; war cache: cord-033146-2v1kuq50.txt plain text: cord-033146-2v1kuq50.txt item: #40 of 115 id: cord-033974-0rzi7x22 author: Boyd, Rhea W title: In the 2020 US election, we can choose a just future date: 2020-10-19 words: 1428 flesch: 59 summary: But while the founding fathers anchored their fledgling democracy in inequality, the expansion of US democracy owes its fragile progress to many forebearers, chief among them are the Indigenous, the formerly enslaved, and women. key: cord-033974-0rzi7x22 authors: Boyd, Rhea W; Krieger, Nancy; Jones, Camara Phyllis title: In the 2020 US election, we can choose a just future date: 2020-10-19 journal: Lancet DOI: 10.1016/s0140-6736(20)32140-1 sha: doc_id: 33974 cord_uid: 0rzi7x22 nan When US voters go to the polls (what few are left) or attempt to mail our ballots (with what remains of the US postal service) in the 2020 election, we are not simply choosing between two parties or posturing about partisan politics. keywords: administration; covid-19; democracy; health; people cache: cord-033974-0rzi7x22.txt plain text: cord-033974-0rzi7x22.txt item: #41 of 115 id: cord-034165-kf6a8hix author: Mendenhall, Emily title: The COVID-19 syndemic is not global: context matters date: 2020-10-22 words: 456 flesch: 50 summary: Recognising contexts are different matters a great deal. These synergistic failures have caused more death and devastation than many other contexts. keywords: contexts; covid-19 cache: cord-034165-kf6a8hix.txt plain text: cord-034165-kf6a8hix.txt item: #42 of 115 id: cord-034191-qqb2knmo author: Alayi, Tchilabalo D. title: Tandem Mass Tag-Based Serum Proteome Profiling for Biomarker Discovery in Young Duchenne Muscular Dystrophy Boys date: 2020-10-06 words: 8978 flesch: 41 summary: Finally, the last group of serum protein biomarkers that were found significantly decreased in young DMD patients relative to age-matched controls are also novel to this study, which include proteins involved in cell signaling such as leukosialin (SPN), macrophage receptor MARCO (MARCO), vitronectin (VTN), galectin-3-binding protein (LGALS3BP), and ProSAAS (PCSK1N). In the past few years, affinity-based serum proteome profiling methods such as SomaScan aptamer-based technology and antibody bead array have contributed to the discovery of a large number of serum protein biomarkers in DMD. 8, 14, 16 keywords: analysis; biomarkers; controls; data; depletion; dmd; dmd patients; figure; mass; muscle; muscular; patients; proteins; samples; serum; study; tmt; total; young cache: cord-034191-qqb2knmo.txt plain text: cord-034191-qqb2knmo.txt item: #43 of 115 id: cord-035181-l1heb3or author: Nagarajan, Kiran Koushik title: Prevalence of US-trained International Medical Graduates (IMG) physicians awaiting permanent residency: a quantitative analysis date: 2020-10-29 words: 2387 flesch: 45 summary: The robust clinical and research experience offered during residency and fellowship training attracts thousands of foreign physicians to the USA each year. There are personal circumstances which may alter our estimate, such as dual foreign physician households (only one family immigrant petition would be required), foreign physicians married to US citizens, foreign physicians who accepted a residency position outside of the NRMP match, and US-trained foreign physicians who may no longer be in practice (left the US, became disabled, or deceased). keywords: data; medical; physicians; residency cache: cord-035181-l1heb3or.txt plain text: cord-035181-l1heb3or.txt item: #44 of 115 id: cord-035277-napw1pxe author: Paul, Swarna Kamal title: A Multivariate Spatiotemporal Model of COVID-19 Epidemic Using Ensemble of ConvLSTM Networks date: 2020-11-11 words: 2797 flesch: 58 summary: KL divergence at pixel level is calculated for total infection cases at the end of prediction period to measure the dissimilarity of distribution of predicted infection cases with respect to actual. MAPE is also calculated at country level with respect to total predicted infection cases across the region during the prediction period. keywords: cases; infection; model; pixel; spread; training cache: cord-035277-napw1pxe.txt plain text: cord-035277-napw1pxe.txt item: #45 of 115 id: cord-248932-i1v2lyd2 author: Madraki, Golshan title: Characterizing and Comparing COVID-19 Misinformation Across Languages, Countries and Platforms date: 2020-10-13 words: 6831 flesch: 44 summary: We show how examining social media misinformation from the perspective of one country, one language, or one platform, misses important and more holistic aspects of the pandemic. Given that politics was the largest root of misinformation across all three languages in this dataset, all societies are extremely vulnerable to government misinformation. keywords: china; chinese; covid-19; english; farsi; government; iran; languages; media; misinformation; platforms; roots; usa cache: cord-248932-i1v2lyd2.txt plain text: cord-248932-i1v2lyd2.txt item: #46 of 115 id: cord-253609-vi2fb43t author: Gopinathannair, Rakesh title: COVID-19 and cardiac arrhythmias: a global perspective on arrhythmia characteristics and management strategies date: 2020-06-03 words: 3204 flesch: 41 summary: Large prospective studies to better define arrhythmic manifestations as well as the safety of treatment strategies in COVID-19 patients are warranted. A variety of supraventricular and ventricular arrhythmias were reported in COVID-19 patients. keywords: azm; covid-19; hcq; patients; respondents; survey; usa cache: cord-253609-vi2fb43t.txt plain text: cord-253609-vi2fb43t.txt item: #47 of 115 id: cord-254874-ug0ler5e author: Ramos-Rincón, José M. title: A snapshot of pneumonia research activity and collaboration patterns (2001–2015): a global bibliometric analysis date: 2019-09-05 words: 6275 flesch: 35 summary: [8, 9] , and finally, the increase in scientific production could be related to scientific development and international dissemination of scientific research in the WoS databases. For now at least, the countries that have traditionally occupied the mainstream of scientific research still maintain their hegemony [48] . keywords: analysis; collaboration; countries; documents; journals; mesh; pneumonia; production; publications; research; study; table cache: cord-254874-ug0ler5e.txt plain text: cord-254874-ug0ler5e.txt item: #48 of 115 id: cord-256888-tdx12ccj author: Bradley, Benjamin T title: Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series date: 2020-07-16 words: 5010 flesch: 42 summary: Patient 3 and patient 9 also had microthrombi in the trachea, although in patient 3 this was qualified by chronic tracheostomy. We hypothesise that there was a subclinical period during which lung injury was occurring in COVID-19 patients with organising diffuse alveolar disease who died in the week after symptom onset. keywords: cov-2; covid-19; diffuse; disease; findings; infection; injury; lung; particles; patients; sars cache: cord-256888-tdx12ccj.txt plain text: cord-256888-tdx12ccj.txt item: #49 of 115 id: cord-257167-rz4r5sj7 author: None title: Abstracts for the 29th Annual Meeting of the Japan Neuroscience Society (Neuroscience2006) date: 2006-12-31 words: 241480 flesch: 43 summary: Inst., Kyoto Univ., Inuyama, Japan GABAergic cells in the cerebral cortex are divided into subgroups: parvalbumin (PV)-, somatostatin (SOM)-, calretinin (CR)-, and calbindin-containing types. In the present study, we therefore investigated the synthesis of sex steroids and corticosteroids in the hippocampus of adult male rats, by monitoring the metabolism of tritiated steroids with HPLC system. PS2A-G125 GABA depolarizes GnRH neurons isolated from adult GnRH-EGFP transgenic rats Chengzhu Yin, Nobuyuki Tanaka, Masakatsu Kato, Yasuo Sakuma Nippon Medical School, Department of physiology, Tokyo, Japan GnRH neurons are essential in the reproductive neuroendocrine system. keywords: 1,2; 100; acid; action; activation; activities; activity; addition; administration; adult; age; amplitude; amygdala; analysis; animals; antagonist; application; area; astrocytes; auditory; axons; bdnf; behavioral; binding; biology; body; brain; brain activity; brain development; brain function; brain research; brain science; bsi; ca1; calcium; camkii; cells; cellular; center; central; cerebellar; cerebral; changes; channel; chiba; cns; cognitive; complex; condition; contrast; control; correlation; cortex; cortex neurons; cortical; crest; cultured; current; data; days; death; decrease; dendrites; dendritic; department; dept; development; difference; differentiation; direction; disease; disorders; distribution; div; division; domain; dopamine; dopaminergic; dorsal; dynamics; effect; estrogen; evoked; excitatory; experiments; exposure; expression; eye; factors; family; fibers; field; findings; firing; fmri; following; formation; fos; frequency; function; funds; gaba; gabaergic; gene; gene expression; gfp; glutamate; gnrh neurons; graduate; granule; group; growth; gyrus; hand; health; high; hippocampal neurons; hippocampus; hiroshi; human; imaging; increase; individual; induced; induction; inhibition; inhibitory; injection; injury; inputs; institute; interaction; interneurons; intracellular; involvement; japan; japan brain; japan neural; japan neurons; japan science; jst; kakenhi; kinase; kyoto; kyoto university; lab; laboratory; layer; learning; left; level; life; like; localization; loss; ltd; ltp; male; manner; mechanisms; med; medical; medicine; membrane; memory; method; mice; microglia; migration; model; molecular; molecules; monkeys; motion; motor; motor neurons; mouse; mouse brain; movement; mrna; multiple; muscle; mutant; nagoya; national; nerve; nervous; network; neural; neurite; neuronal; neurons; neuroscience; new; nmda; non; novel; nuclei; nucleus; number; olfactory; onset; order; osaka; osaka university; pain; pathway; patients; pattern; period; phase; phosphorylation; physiology; plasticity; play; postnatal; postsynaptic; potential; prefrontal; presence; present; presynaptic; primary; process; processes; processing; progenitor cells; projection neurons; proliferation; properties; protein; ps2p; ps3a; ps3p; purkinje cells; pyramidal; rat brain; rate; rats; receptor; recorded; recording; reduced; region; regulation; relationship; release; report; required; research; research funds; research institute; response; results; reward; right; riken; role; saitama; school; sciences; second; selective; sensory; signaling; signals; site; size; slices; social; specific; spike; spinal; spines; state; stem cells; stimulation; stimuli; stimulus; stress; structure; studies; study; subjects; surface; synapses; synaptic; system; target; task; technology; temporal; term; terminals; test; time; tohoku; tokyo; tokyo university; transcription; transgenic; transmission; treatment; tsukuba; type; university; university graduate; university school; usa; visual; vitro; vivo; voltage; weeks; wild; zone cache: cord-257167-rz4r5sj7.txt plain text: cord-257167-rz4r5sj7.txt item: #50 of 115 id: cord-257190-iesysf3l author: Eshaghi, Majid title: Purification of the extra-cellular domain of Nipah virus glycoprotein produced in Escherichia coli and possible application in diagnosis date: 2005-03-30 words: 2909 flesch: 41 summary: Furthermore, the advantages of using a prokaryotic host to produce recombinant G protein would be considerable due to the ease of scale-up, and the low costs involved in growing bacteria. The aim was to determine the variability of negative and positive sera using ELISA based on recombinant G protein. keywords: niv; protein; recombinant; usa; virus cache: cord-257190-iesysf3l.txt plain text: cord-257190-iesysf3l.txt item: #51 of 115 id: cord-258468-52gej3co author: Marcekova, Zuzana title: Heterologous expression of full-length capsid protein of porcine circovirus 2 in Escherichia coli and its potential use for detection of antibodies date: 2009-08-05 words: 7015 flesch: 41 summary: The open reading frame encoding Cap protein was amplified using PCR from genomic DNA of PCV 2 (L14181 isolate) and the 707 bp long DNA fragment was cloned into pET28b expression vector (Fig. 1B) . In order to eliminate the cluster of rare codons from the 5 end of the cap gene, the expression vector encoding a truncated variant of Cap protein ( Cap-His), which was lacking the first 16 amino acid residues, was constructed (Fig. 1B) . keywords: cap; cap protein; capsid; cells; circovirus; coli; et al; expression; fig; gene; pcv; porcine; protein cache: cord-258468-52gej3co.txt plain text: cord-258468-52gej3co.txt item: #52 of 115 id: cord-260618-k0y0fz7k author: Belli, Simone title: Coronavirus mapping in scientific publications: When science advances rapidly and collectively, is access to this knowledge open to society? date: 2020-07-01 words: 9647 flesch: 45 summary: If we put the number of documents provided in relation to the total number of links generated with other countries, we see proportionally higher values than in the sample for 2001-2020, going from an average of 0.96 links generated by documents in the total period to 1.16 links for the 20 countries with the largest contribution of documents to the sample for each period. Other countries that offer a low proportion of links throughout the whole period show a slight rise in 2019-2020, such as South Korea that goes from 0.34 to 0.54 links per document and 25.81% to 29.41% of documents fruit of international collaboration, or Brazil that goes from 0.38 to 0.43 links per document and 31.79% to 34.78% of international documents. keywords: articles; china; collaboration; countries; documents; links; number; organizations; period; publications; research cache: cord-260618-k0y0fz7k.txt plain text: cord-260618-k0y0fz7k.txt item: #53 of 115 id: cord-260653-5qwtvm9x author: Chikhlikar, Priya title: DNA Encoding an HIV-1 Gag/Human Lysosome-Associated Membrane Protein-1 Chimera Elicits a Broad Cellular and Humoral Immune Response in Rhesus Macaques date: 2006-12-27 words: 6151 flesch: 45 summary: The longevity of the immunological memory of B cells and CD8 + cells is also increased in animals immunized with LAMP/chimeras. The larger fraction of CD8 + T cells expressing IFN-c (.20%) following inoculation with recombinant vaccinia virus encoding Gag, in comparison with the proportion of tetramer positive cells, is attributed to the massive in vivo expansion of Gag-activated CD8 + T cells reactive against several other Gag MHC I epitopes, besides the immunodominant H-2Kd-AMQMLKETI peptide-tetramer epitope complex. keywords: antigen; cd8; cells; dna; gag; human; lamp; macaques; responses; usa cache: cord-260653-5qwtvm9x.txt plain text: cord-260653-5qwtvm9x.txt item: #54 of 115 id: cord-262169-5x2oop1g author: Alola, Andrew Adewale title: The nCOVID-19 and financial stress in the USA: health is wealth date: 2020-10-08 words: 3188 flesch: 39 summary: By employing the empirical Markov switching regression approach and the compliments of cointegration techniques, the study establishes a two-state (stable and distressing) financial stress situation resulting from the effects of COVID-19 daily deaths, COVID-19 daily recovery, and the USA’ economic policy uncertainty. Similar to the impact of COVID-19 daily deaths on the Americans' financial stress, the degree of uncertainty in the country's economic policy is a significant determinant of financial stress. keywords: covid-19; daily; deaths; financial; pandemic; stress; usa cache: cord-262169-5x2oop1g.txt plain text: cord-262169-5x2oop1g.txt item: #55 of 115 id: cord-263453-7v4y02j6 author: Nishiura, Hiroshi title: Early Epidemiological Assessment of the Virulence of Emerging Infectious Diseases: A Case Study of an Influenza Pandemic date: 2009-08-31 words: 5352 flesch: 48 summary: doi:10.1371/journal.pone.0006852.g003 Figure 6 shows the time course of biased cCFR estimates in the USA and Canada based on the reporting date of confirmed cases and deaths to the World Health Organization. We first examine the approach by analyzing an outbreak of severe acute respiratory syndrome in Hong Kong (2003) with known unbiased cCFR estimate, and then investigate published epidemiological datasets of novel swine-origin influenza A (H1N1) virus infection in the USA and Canada (2009). keywords: cases; ccfr; deaths; estimate; onset; time cache: cord-263453-7v4y02j6.txt plain text: cord-263453-7v4y02j6.txt item: #56 of 115 id: cord-267168-qjktnnn6 author: Wille, Michelle title: Evolutionary genetics of canine respiratory coronavirus and recent introduction into Swedish dogs date: 2020-03-20 words: 6280 flesch: 45 summary: A small number of isolates have also been sequenced and characterized (An et al., 2010a; Erles et al., 2003 Erles et al., , 2007 Jeoung et al., 2014; Yachi and Mochizuki, 2006 infections in a number of avian and mammalian species. For the first approach, PCR reactions targeting the S, Membrane (M) and Hemagglutinin-esterase (HE) genes were carried out using previously published primers (An et al., 2010a; Erles et al., 2007) (Table A2 ) using KAPA2G Robust HotStart ReadyMix PCR Kit (KAPA Biosystems, Roche Sequencing, Pleasanton, CA, USA). keywords: bcov; canine; coronavirus; crcov; dogs; et al; fig; gene; recombination; respiratory; sequencing; sweden; swedish; usa; viruses cache: cord-267168-qjktnnn6.txt plain text: cord-267168-qjktnnn6.txt item: #57 of 115 id: cord-270143-muxrxvyo author: Markotter, Wanda title: Paramyxo- and Coronaviruses in Rwandan Bats date: 2019-07-02 words: 4903 flesch: 43 summary: Host gene sequences were subsequently compared to bat sequences available in the public domain (on the NCBI GenBank and BOLD databases), results were interpreted and compared with the respective morphological field identifications. In addition to morphological identification of bat species, we also did molecular confirmation of species identities, contributing to the known genetic database available for African bat species. keywords: africa; assay; bats; coronaviruses; host; paramyxoviruses; rna; rwanda; samples; sequences; species; usa; viruses cache: cord-270143-muxrxvyo.txt plain text: cord-270143-muxrxvyo.txt item: #58 of 115 id: cord-270425-1ughypnx author: Louis-Jean, James title: Coronavirus (COVID-19) and Racial Disparities: a Perspective Analysis date: 2020-10-06 words: 3738 flesch: 46 summary: Many African Americans infected with syphilis were promised treatment from the Public Health Department. Program Limitations in the use of race in the study of disease causation Seeking causal explanations in social epidemiology Socio-ecological stress, suppressed hostility, skin color, and black-white male blood pressure: Detroit Preliminary estimates of the prevalence of selected underlying health conditions among patients with Coronavirus Disease 2019 -United States Vital signs: racial disparities in age-specific mortality among blacks or African Americans -United States At the dark end of the street: black women, rape, and resistance-a new history of the civil rights movement from Rosa parks to the rise of black power From slavery to freedom: a history of African Americans Who is Homeless? keywords: african; americans; communities; covid-19; health; healthcare; pandemic; usa; virus cache: cord-270425-1ughypnx.txt plain text: cord-270425-1ughypnx.txt item: #59 of 115 id: cord-270556-lyrgwxit author: Winnicka, Beata title: CD13 is dispensable for normal hematopoiesis and myeloid cell functions in the mouse date: 2010-04-29 words: 8870 flesch: 37 summary: As CD13 has been implicated in numerous myeloid cell functions, we wished to assess the function of CD13 null cells in these aspects. Although overall adhesion of CD13 null cells was slightly lower than WT to untreated or control monolayers, treatment of the endothelial monolayer with cross-linking anti-mCD13 antibodies significantly increased the adhesion of WT but not CD13 null macrophages (Fig. keywords: adhesion; aminopeptidase; analysis; animals; anti; cd13; cells; control; endothelial; expression; fig; function; human; macrophages; mice; myeloid; peritoneal; phagocytosis; protein; usa cache: cord-270556-lyrgwxit.txt plain text: cord-270556-lyrgwxit.txt item: #60 of 115 id: cord-271176-wdc4p4bc author: González-Scarano, Francisco title: Infectious etiology in multiple sclerosis: the debate continues date: 1999-12-01 words: 2315 flesch: 32 summary: Although there were calls from conference 'break-out' sessions for better stratification of MS patients in epidemiological studies, the consensus of studies pointing in the direction of an environmental cause, as well as the evidence from the oligoclonal immune responses, convinced the majority of delegates that MS is likely to be caused or triggered by an infectious agent. Subramamiam Sriram (Vanderbilt Stallworth Rehabilitation Hospital, Memphis, TN, USA) presented data indicating that the CSF of 97% of MS patients (compared with 18% of patients with other neurological diseases) contains genomic material from the bacterium Chlamydia pneumoniae, as shown by PCR amplification. keywords: cns; disease; infection; patients; tuberculosis; usa cache: cord-271176-wdc4p4bc.txt plain text: cord-271176-wdc4p4bc.txt item: #61 of 115 id: cord-272497-ww9o1kjr author: Al-Anzi, Bader S. title: An Overview of the World Current and Future Assessment of Novel COVID-19 Trajectory, Impact, and Potential Preventive Strategies at Healthcare Settings date: 2020-09-25 words: 8899 flesch: 55 summary: For example, the total predicted total COVID-19 infected cases for Brazil, India, and USA by 15 August is expected to be around 6,000,000, 3,259,917, and 5,800,000 with the number of deaths expected to be equal to 200,000, 60,000, and 1,600,000, respectively. For example, the total predicted total COVID-19 infected cases for Brazil, India, and USA by 15 August is expected to be around 6,000,000, 3,259,917, and 5,800,000 with the number of deaths expected to be equal to 200,000, 60,000, and 1,600,000, respectively. keywords: cases; countries; covid-19; group; interval; model; stage; total; world cache: cord-272497-ww9o1kjr.txt plain text: cord-272497-ww9o1kjr.txt item: #62 of 115 id: cord-273199-xmq502gm author: Cherednik, I. title: A surprising formula for the spread of Covid-19 under aggressive management date: 2020-05-02 words: 5044 flesch: 61 summary: The reality now is the power-type growth of total number of infections U (t) after a possible short period of exponential growth, Covid-19 included. For Covid-19, c is around 2, which results in the quadratic growth of total number of infections after a short period of its exponential growth. keywords: growth; infections; measures; number; preprint cache: cord-273199-xmq502gm.txt plain text: cord-273199-xmq502gm.txt item: #63 of 115 id: cord-273557-t7t8qqkl author: Boumans, Dorine title: Expected effects of the US tax reform on other countries: global and local survey evidence date: 2020-08-11 words: 6832 flesch: 54 summary: Non-US market reactions to US tax reform A preliminary assessment of the Tax Cuts and Jobs Act of 2017 Forecasting GDP all over the world using leading indicators based on comprehensive survey data Issues in international corporate taxation Tax reform made me do it! Taxes paid abroad were credited against US tax. keywords: countries; effects; firms; impact; investment; profits; reform; survey; tax; tcja; usa cache: cord-273557-t7t8qqkl.txt plain text: cord-273557-t7t8qqkl.txt item: #64 of 115 id: cord-273833-yf8kt84e author: Mejia, Rojelio title: Global COVID-19 Efforts as the Platform to Achieving the Sustainable Development Goals date: 2020-08-20 words: 2546 flesch: 45 summary: To be successful and achieve the global goals including the control of pandemics such as the one seen from the COVID-19, we must rely on strong leadership leading to impactful public policies and global collaborations, including global COVID-19 vaccinations, and potentially linking them to programs for childhood and adult vaccinations and programs for malaria, tuberculosis, HIV/AIDS, and neglected tropical disease treatments. Major US cities had high levels of COVID-19 infections and a higher prevalence in those living below the poverty line [28] . keywords: areas; coronavirus; covid-19; disease; health; populations; poverty cache: cord-273833-yf8kt84e.txt plain text: cord-273833-yf8kt84e.txt item: #65 of 115 id: cord-275210-baqaqsli author: DREESEN, DAVID W. title: Animal Vaccines date: 2007-09-05 words: 5277 flesch: 41 summary: In his quest for a means to prevent rabies in humans, Louis Pasteur initiated research into animal rabies vaccine in France in the early 1880s (Bunn, 1991) . The WHO's World Survey of Rabies reported that there are at least 23 countries or territories that reported producing animal rabies vaccines during 1999. keywords: animals; cats; dogs; rabies; strain; usa; use; vaccination; vaccines; virus cache: cord-275210-baqaqsli.txt plain text: cord-275210-baqaqsli.txt item: #66 of 115 id: cord-275604-5u4kikov author: Feehan, Amy K. title: Seroprevalence of SARS-CoV-2 and Infection Fatality Ratio, Orleans and Jefferson Parishes, Louisiana, USA, May 2020 date: 2020-11-17 words: 1421 flesch: 46 summary: Our study found the overall SARS-CoV-2 exposure rate in this area to be 7.8% and confirmed a recent report of overrepresentation of Black persons with COVID-19 in the New Orleans area (5) . Study participants for whom either or both tests were positive were considered to be infected with SARS-CoV-2. keywords: infection; participants; persons; sars; seroprevalence cache: cord-275604-5u4kikov.txt plain text: cord-275604-5u4kikov.txt item: #67 of 115 id: cord-275787-5s442sy2 author: Banerjee, Arinjay title: Generation and Characterization of Eptesicus fuscus (Big brown bat) kidney cell lines immortalized using the Myotis polyomavirus large T-antigen date: 2016-09-14 words: 5831 flesch: 50 summary: Establishing bat cell lines enable researchers to study relevant virus-host interactions in a system that more closely resembles the reservoir host. Interferon response in terms of interferon beta transcript upregulation by bat cell lines, mostly cell lines from fruit bats, has been demonstrated before (Hagmaier et al., 2007; Crameri et al., 2009; Biesold et al., 2011; Virtue et al., 2011) . keywords: antigen; bat; bats; beta; cells; clones; cov; interferon; line; pcr; replication; usa; viruses cache: cord-275787-5s442sy2.txt plain text: cord-275787-5s442sy2.txt item: #68 of 115 id: cord-280807-0g1uo0rd author: Tomani, Jean Claude Didelot title: The Inhibition of NLRP3 Inflammasome and IL-6 Production by Hibiscus noldeae Baker f. Derived Constituents Provides a Link to Its Anti-Inflammatory Therapeutic Potentials date: 2020-10-14 words: 8146 flesch: 43 summary: Overall, our work does provide the very first scientific based evidence for Hibiscus noldeae anti-inflammatory effects and widespread use by traditional healers in Rwanda for a variety of ailments. Several studies have reported the role of different inflammatory cells and mediators in the pathogenesis of asthma where the volume and nature of involved inflammatory mediators determine the severity and exacerbations of the disease. keywords: activation; asthma; caspase-1; cell; fractions; il-1β; il-6; inflammasome; nlrp3; noldeae; production; usa cache: cord-280807-0g1uo0rd.txt plain text: cord-280807-0g1uo0rd.txt item: #69 of 115 id: cord-281395-qxu41hta author: Rogers, M. A. M. title: Haemovigilance of reactions associated with red blood cell transfusion: comparison across 17 Countries date: 2015-12-21 words: 3316 flesch: 38 summary: AHRQ Publication No. 13(14)-EHC084-EF Transfusion-associated circulatory overload in orthopedic surgery patients: a multi-institutional study An analysis of blood management in patients having a total hip or knee arthroplasty Transfusion-related acute lung injury and pulmonary edema in critically ill patients: a retrospective study Incidence and transfusion risk factors for transfusion-associated circulatory overload among medical intensive care unit patients Hemotherapy bedside biovigilance involving vital sign values and characteristics of patients with suspected transfusion reactions associated with fluid challenges: can some cases of transfusion-associated circulatory overload have proinflammatory aspects? Characterizing the epidemiology of perioperative transfusion-associated circulatory overload Transfusion-associated circulatory overload (TACO) and potential risk factors among the inpatient US elderly as recorded in Medicare administrative databases during Reduction of febrile but not allergic reactions to RBCs and platelets after conversion to universal prestorage leukoreduction Premedication with acetaminophen or diphenhydramine for transfusion with leucoreduced blood products in children A prospective, randomized, doubleblind controlled trial of acetaminophen and diphenhydramine pretransfusion medication versus placebo for the prevention of transfusion reactions Febrile transfusion reaction: what blood component should be given next? Both Ireland and the USA tended to have delayed haemolytic transfusion reactions at a greater frequency than other countries, although the confidence intervals for Ireland were wide indicating fewer RBC units due to a smaller population. keywords: blood; haemovigilance; rates; rbc; reactions; transfusion; units; usa cache: cord-281395-qxu41hta.txt plain text: cord-281395-qxu41hta.txt item: #70 of 115 id: cord-281713-3iu8qx7n author: Ronquillo, Jay G title: Using informatics to guide public health policy during the COVID-19 pandemic in the USA date: 2020-07-13 words: 1989 flesch: 38 summary: However, effective public health solutions for COVID-19 and future pandemics will require access to interoperable public health data at all levels. Trends in cases and deaths adjusted for state populations and resource estimates are visualized in Figure 1 . keywords: cases; covid-19; data; deaths; health; pandemic cache: cord-281713-3iu8qx7n.txt plain text: cord-281713-3iu8qx7n.txt item: #71 of 115 id: cord-282466-r2sjv9ih author: Antas, Marta title: Current Status of Porcine Epidemic Diarrhoea (PED) in European Pigs date: 2019-10-24 words: 3325 flesch: 48 summary: Porcine epidemic diarrhea virus: an emerging and re-emerging epizootic swine virus Pathogenesis comparison between the United States porcine epidemic diarrhoea virus prototype and S-INDEL-variant strains in conventional neonatal piglets Isolation and characterization of porcine epidemic diarrhea viruses associated with the 2013 disease outbreak among swine in the United States Scientific opinion on porcine epidemic diarrhea and emerging porcine deltacoronavirus Coronaviruses: an overview of their replication and pathogenesis Porcine epidemic diarrhea virus in North America Neutralizing antibodies against porcine epidemic diarrhea virus block virus attachment and internalization Evolutionary and genotypic analyses of global porcine epidemic diarrhea virus strains Immunohistochemical detection of porcine epidemic diarrhoea virus compared to other methods Porcine epidemic diarrhea in Europe: indetail analyses of disease dynamics and molecular epidemiology Origin, evolution, and genotyping of emergent porcine epidemic diarrhea virus strains in the United States Genomic and evolutionary inferences between American and global strains of porcine epidemic diarrhea virus Aminopeptidase-Nindependent entry of porcine epidemic diarrhea virus into Vero or porcine small intestine epithelial cells Immunogenicity and protective efficacy of recombinant S1 domain of the porcine epidemic diarrhea virus spike protein Porcine epidemic diarrhea virus infection: etiology, epidemiology, pathogenesis, and immunoprophylaxis Multiplex real-time RT-PCR for the simultaneous detection and quantification of transmissible gastroenteritis virus and porcine epidemic diarrhea virus Porcine epidemic diarrhea virus: an emerging and reemerging epizootic swine virus Porcine epidemic diarrhea virus: current insights Epidemic of diarrhoea caused by porcine epidemic diarrhoea virus in Italy Emerging and reemerging diseases in Asia and the Pacific with special emphasis on porcine epidemic diarrhoea Porcine epidemic diarrhea (PED) in Europe and strategies to control outbreaks Porcine epidemic diarrhea: a retrospect from Europe and matters of debate Variations in the detection of anti-PEDV antibodies in serum samples using three diagnostic testsshort communication Diagnostic notes update on porcine epidemic diarrhea Full-length genome sequences of porcine epidemic diarrhoea virus strain CV777; use of NGS to analyse genomic and sub-genomic RNAs Coronaviruses. in: Diseases of swine Characterizing the rapid spread of porcine epidemic diarrhea virus (PEDV) through an animal food manufacturing facility Porcine epidemic diarrhea virus: a comprehensive review of molecular epidemiology, diagnosis and vaccines Quercetin 7-rhamnoside reduces porcine epidemic diarrhea virus replication via independent pathway of viral induced reactive oxygen species Investigation of three outbreaks of porcine epidemic diarrhea in Germany in 2016 demonstrates age dependent differences in the development of humoral immune response A retrospective study detects a novel variant of porcine epidemic diarrhea virus in England in archived material from the year Factors associated with farm-level infection of porcine epidemic diarrhea during the early phase of the epidemic in Japan in Discovery of seven novel mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus Porcine epidemic diarrhea virus variants with high pathogenicity Evolutionary insights into the ecology of coronaviruses Distinct characteristics and complex evolution of PEDV strains Molecular characteristics of the spike gene of porcine epidemic diarrhoea virus strains in Eastern China in 2016 keywords: diarrhea; epidemic; pedv; pigs; porcine; strains; usa; virus cache: cord-282466-r2sjv9ih.txt plain text: cord-282466-r2sjv9ih.txt item: #72 of 115 id: cord-284113-qboon2uv author: Zheljazkov, Valtcho D. title: Industrial, CBD, and Wild Hemp: How Different Are Their Essential Oil Profile and Antimicrobial Activity? date: 2020-10-12 words: 7536 flesch: 54 summary: Some previous reports identified a different number of EO constituents in hemp EO (e.g., 55 EO constituents, with myrcene, α-pinene, and β-pinene as the main monoterpenes, and β-caryophyllene as the main sesquiterpene) However, due to the depressed markets and expensive feminized seed (US$1/seed), there is now significant interest in hemp EO from industrial hemp cultivars and even from wild hemp. keywords: breeding; cannabis; caryophyllene; cbd; concentration; constituents; cultivars; hemp; hemp eo; lines; wild; wild hemp cache: cord-284113-qboon2uv.txt plain text: cord-284113-qboon2uv.txt item: #73 of 115 id: cord-285505-8norumv6 author: Vere Hodge, R. Anthony title: Meeting report: 27th International conference on antiviral research, in Raleigh, NC, USA date: 2014-09-16 words: 10298 flesch: 57 summary: These are followed by brief summaries of the keynote addresses and the three mini-symposia on 'Hepatitis B virus', 'Research Triangle Park' and 'Challenges in HIV infection, treatment and prevention'. Although this patient continues to have no sign of HIV infection, this is hardly a viable treatment option for most HIV-infected patients. keywords: activity; antiviral; cells; dna; drug; hbv; hiv; infection; nucleotide; phase; polymerase; prodrug; replication; research; rna; studies; tdf; therapy; treatment; trial; usa; virus cache: cord-285505-8norumv6.txt plain text: cord-285505-8norumv6.txt item: #74 of 115 id: cord-287647-0nyquokt author: Nemoto, Manabu title: The First Detection of Equine Coronavirus in Adult Horses and Foals in Ireland date: 2019-10-14 words: 2717 flesch: 54 summary: The much higher incidence of ECoV positive Thoroughbred foals identified in Kentucky compared to similar populations internationally suggests an increased susceptibility to ECoV infection in that population. Thus, an investigation of ECoV in Ireland is pertinent not only to increase awareness nationally of the epidemiology of the virus and promote discussion on its clinical importance, but also to inform the industry globally of the health status of Irish horses. keywords: coronavirus; ecov; equine; gene; horses; samples cache: cord-287647-0nyquokt.txt plain text: cord-287647-0nyquokt.txt item: #75 of 115 id: cord-287807-4aee9wbu author: Kennedy, J. L. title: Complete Genome Sequence of a Novel WU Polyomavirus Isolate from Arkansas, USA, Associated with Acute Respiratory Infection date: 2017-01-12 words: 914 flesch: 41 summary: Cloning of a human parvovirus by molecular screening of respiratory tract samples Identification of a novel polyomavirus from patients with acute respiratory tract infections A taxonomy update for the family Polyomaviridae Whole-genome characterization and genotyping of global WU polyomavirus strains Reactivation and mutation of newly discovered WU, KI, and Merkel cell carcinoma polyomaviruses in immunosuppressed individuals Presence of the newly discovered human polyomaviruses KI and WU in Australian patients with acute respiratory tract infection Acquisition of human polyomaviruses in the first 18 months of life WU polyomavirus infection in children Discovery and identification of WU polyomavirus in children from Zhejing region Complete genome sequence of a novel human WU polyomavirus isolate associated with acute respiratory infection Genome analysis of the new human polyomaviruses WU polyomavirus (WUPyV): a recently detected virus causing respiratory disease? key: cord-287807-4aee9wbu authors: Kennedy, J. L.; Denson, J. L.; Schwalm, K. S.; Stoner, A. N.; Kincaid, J. C.; Abramo, T. J.; Thompson, T. M.; Ulloa, E. M.; Burchiel, S. W.; Dinwiddie, D. L. title: Complete Genome Sequence of a Novel WU Polyomavirus Isolate from Arkansas, USA, Associated with Acute Respiratory Infection date: 2017-01-12 journal: keywords: genome; isolate; polyomavirus cache: cord-287807-4aee9wbu.txt plain text: cord-287807-4aee9wbu.txt item: #76 of 115 id: cord-290837-8g7zfeb7 author: Wanandy, Troy title: Pharmaceutical and preclinical evaluation of Advax adjuvant as a dose-sparing strategy for ant venom immunotherapy date: 2019-08-05 words: 6091 flesch: 40 summary: In the current study, we performed stability study of low-dose JJA VIT with and without Advax adjuvant, pre-packaged in plastic syringes thereby confirming that the JJA VIT and Advax components were compatible with each other, and minimal aggregation of delta inulin microparticles was observed in the period studied. Low-dose JJAV formulated with Advax adjuvant induced significantly higher JJAV-specific IgG than a 5-fold higher dose of JJAV alone, consistent with a powerful allergen-sparing effect. keywords: adjuvant; advax; dose; jjav; samples; specific; stability; study; venom; vit cache: cord-290837-8g7zfeb7.txt plain text: cord-290837-8g7zfeb7.txt item: #77 of 115 id: cord-292231-vxaqizkj author: Bouquet, Jerome title: Microbial burden and viral exacerbations in a longitudinal multicenter COPD cohort date: 2020-03-30 words: 5753 flesch: 31 summary: These findings are interesting because they mirror another study showing the partitioning of COPD exacerbation samples into 3 cytokine profile clusters [3] with associations to specific ratios of Proteobacteria, Firmicutes and Bacteroidetes that highlighted the heterogeneity of exacerbation profiles in COPD patients. Prevotella, Streptococcus and Veillonella represented the majority of the microbiota in samples collected at stable states, Haemophilus and Moraxella were predominant in acute exacerbation samples, and Pseudomonas was prevalent in exacerbation follow-up samples (Fig. 2b ). keywords: copd; disease; diversity; exacerbation; fig; infections; lung; microbiota; patients; samples; study; usa cache: cord-292231-vxaqizkj.txt plain text: cord-292231-vxaqizkj.txt item: #78 of 115 id: cord-292643-n6xp5mlz author: Hall, Richard J. title: Evaluation of rapid and simple techniques for the enrichment of viruses prior to metagenomic virus discovery date: 2013-09-13 words: 4829 flesch: 35 summary: The application of virus discovery methods using metagenomics has been considered for routine use in diagnostic and reference laboratories to aid in the diagnosis of human (Svraka et al., 2010) and animal disease (Belak et al., 2013) . This finding supports the use of the 3-step procedure for virus enrichment, and similar 3-step procedures have previously been employed in published virus metagenomic studies (Table 1) . keywords: dna; enrichment; human; methods; pcr; rna; sample; step; treatment; usa; viruses cache: cord-292643-n6xp5mlz.txt plain text: cord-292643-n6xp5mlz.txt item: #79 of 115 id: cord-293747-ds8rhbkv author: Lani, Rafidah title: Antiviral activity of silymarin against chikungunya virus date: 2015-06-16 words: 5091 flesch: 46 summary: This data also indicates that silymarin can interfere with CHIKV RNA replication by affecting the viral replicase system. This finding is consistent with that from previous assay and confirms that silymarin suppresses CHIKV RNA replication and does it in dose-dependent manner. keywords: activity; antiviral; assay; cells; chikungunya; chikv; replication; rna; silymarin; usa; virus cache: cord-293747-ds8rhbkv.txt plain text: cord-293747-ds8rhbkv.txt item: #80 of 115 id: cord-295445-f4p00yaw author: Wang, Hao title: Differential removal of human pathogenic viruses from sewage by conventional and ozone treatments date: 2018-02-01 words: 6892 flesch: 40 summary: Water Sa Evaluation of positively charged alumina nanofibre cartridge filters for the primary concentration of noroviruses, adenoviruses and male-specific coliphages from seawater Diarrhea and enteric emerging viruses in HIVinfected patients Detection of pathogenic viruses in sewage provided early warnings of hepatitis A virus and norovirus outbreaks Diversity of environmental single-stranded DNA phages revealed by PCR amplification of the partial major capsid protein New method using a positively charged microporous filter and ultrafiltration for concentration of viruses from tap water Mechanism of ozone inactivation of bacteriophage f2 Application of ozone for enhancing the microbiological safety and quality of foods: a review Disinfection of wastewater with peracetic acid: a review Environmental persistence and transfer of enteric viruses Mucosal and cutaneous human papillomaviruses detected in raw sewages Previously unknown evolutionary groups dominate the ssDNA gokushoviruses in oxic and anoxic waters of a coastal marine environment Quantitative RT-PCR for the enumeration of noroviruses (Norwalk-like viruses) in water and sewage Profile and fate of bacterial pathogens in sewage treatment plants revealed by high-Throughput metagenomic approach Presence of noroviruses and other enteric viruses in sewage and surface waters in The Netherlands Pathogenic enteric viruses and microbial indicators during secondary treatment of municipal wastewater Tracing of norovirus outbreak strains in mussels collected near sewage effluents Diversity of viruses associated with acute gastroenteritis in children hospitalized with diarrhea in Ho Chi Minh City, Vietnam Disinfection and oxidation of sewage effluent water using ozone and UV technologies Removal of viruses, parasitic protozoa and microbial indicators in conventional and membrane processes in a wastewater pilot plant Removal of noro-and enteroviruses, Giardia cysts, Cryptosporidium oocysts, and fecal indicators at four secondary wastewater treatment plants in Sweden Removal of noro-and enteroviruses Giardia cysts, Cryptosporidium oocysts, and fecal indicators at four secondary wastewater treatment plants in Sweden Visualizing phylogenetic trees using TreeView Effect of disinfection of drinking-Water with ozone or chlorine dioxide on survival of cryptosporidium-parvum oocysts Acute diarrhea in West African children: diverse enteric viruses and a novel parvovirus genus The fecal virome of South and Central American children with diarrhea includes small circular DNA viral genomes of unknown origin Wastewater disinfection with ozone -process control and operating results Uses of Ozone in Drinking Water Treatment Standard and new faecal indicators and pathogens in sewage treatment plants, microbiological parameters for improving the control of reclaimed water Reproducible (1)H NMRbased metabolomic responses in fish exposed to different sewage effluents in two separate studies Science and technology for water purification in the coming decades Tyrrell et al., 1995) , but knowledge regarding its effect for reducing human enteric viruses is relatively scarce. keywords: adenovirus; et al; human; min; ozone; pcr; samples; sewage; treatment; viruses; wastewater; water cache: cord-295445-f4p00yaw.txt plain text: cord-295445-f4p00yaw.txt item: #81 of 115 id: cord-295661-v3q1spmm author: Resende, Talita Pilar title: Evaluation of mouse enteroids as a model for Lawsonia intracellularis infection date: 2019-07-19 words: 5464 flesch: 26 summary: To determine whether L. intracellularis infection induces changes in the proliferation and differentiation of enteroid epithelial cells, as observed in the swine intestine, we evaluated expression of Ki-67, Sox9 and Muc2 in enteroids harvested at 1, 3 and 7 dpi relative to expression in enteroids at 0 dpi. B L. intracellularis antigen is associated with cell debris (arrow heads) and in close proximity to enteroid cells (black arrows), ×200. keywords: antigen; cells; culture; dpi; enteroids; infected; infection; intracellularis; lawsonia; mouse; proliferation; usa cache: cord-295661-v3q1spmm.txt plain text: cord-295661-v3q1spmm.txt item: #82 of 115 id: cord-297332-rzf0cw1x author: Wang, Qidi title: Immunodominant SARS Coronavirus Epitopes in Humans Elicited both Enhancing and Neutralizing Effects on Infection in Non-human Primates date: 2016-04-11 words: 8711 flesch: 49 summary: Coronavirus: Insight into the Humoral Immunity of SARS Screening and identification of linear B-cell epitopes and entry-blocking peptide of severe acute respiratory syndrome (SARS)-associated coronavirus using synthetic overlapping peptide library Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2 Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2 Characterization of the heptad repeat regions, HR1 and HR2, and design of a fusion core structure model of the spike protein from severe acute respiratory syndrome (SARS) coronavirus Crystal structure of severe acute respiratory syndrome coronavirus spike protein fusion core Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins Antibodydependent infection of human macrophages by severe acute respiratory syndrome coronavirus Anti-Severe Acute Respiratory Syndrome Coronavirus Spike Antibodies Trigger Infection of Human Immune Cells via a pH-and Cysteine Protease-Independent FcγR Pathwa Synthesis of proteins by native chemical ligation Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection Generation of High-Affinity Antibody against T Cell-Dependent Antigen in the Ganp Gene-Transgenic Mouse A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication Real-time biospecific interaction analysis using surface plasmon resonance and sensor chip technology Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system Author Contributions ∥ W.Q.D., Z.L.F., and K.K. equally contributed to this work. Using antibodies from SARS patients, we identified and characterized SARS-CoV B-cell peptide epitopes with disparate functions. keywords: ade; antibodies; antibody; cells; coronavirus; cov; dpi; enhancement; figure; group; human; infection; lung; macaques; min; peptide; protein; sars; virus cache: cord-297332-rzf0cw1x.txt plain text: cord-297332-rzf0cw1x.txt item: #83 of 115 id: cord-300904-folzz3nu author: Uzuner, Gizem title: Tourist arrivals in four major economies: another side of economic policy uncertainty and fear date: 2020-05-26 words: 3198 flesch: 41 summary: Evidence from selected small island states Examining the causal impacts of tourism, globalization, economic growth and carbon emissions in tourism island territories: bootstrap panel Granger causality analysis Economic policy uncertainty and tourism: evidence from the heterogeneous panel The dynamics of tourism-refugeeism on house prices in Cyprus and Malta Agricultural land usage and tourism impact on renewable energy consumption among coastline Mediterranean countries Impact of corruption and insurgency on tourism performance: a case of a developing country Modeling tourism and fear nexus in G4 countries Measuring economic policy uncertainty Terrorism and tourism demand: a case study of Lebanon, Turkey and Israel The Lagrange multiplier test and its applications to model specification in econometrics National and international tourism booming Migration fear, uncertainty, and macroeconomic dynamics (No Sentiment, mood and outbound tourism demand Testing for Granger causality in heterogeneous mixed panels Testing the role of tourism and human capital development in economic growth. Empirical results show that migration-related fear is linked with EPU, tourism arrivals, and real income. keywords: causality; countries; fear; migration; tourism; uncertainty cache: cord-300904-folzz3nu.txt plain text: cord-300904-folzz3nu.txt item: #84 of 115 id: cord-301745-cuatqy1u author: Wei, Maryann title: Social Distancing and Lockdown – An Introvert’s Paradise? An Empirical Investigation on the Association Between Introversion and the Psychological Impact of COVID19-Related Circumstantial Changes date: 2020-09-17 words: 4310 flesch: 32 summary: On that grounds that introverts prefer less stimulating environments (Myers, 1962; Cattell, 1965; Eysenck, 1967; Hathaway, 1982; McCrae and Costa, 1999) , the assumption that introverts experience the psychological impact of COVID19related circumstantial changes less severely than extraverts seems plausible. Although increased amounts of time alone should in theory be welcome by introverts, these findings raise questions on whether introverts necessarily have an advantage over their extraverted counterparts in adapting to COVID19related circumstantial changes. keywords: changes; circumstantial; covid19; introversion; loneliness; usa cache: cord-301745-cuatqy1u.txt plain text: cord-301745-cuatqy1u.txt item: #85 of 115 id: cord-303165-ikepr2p2 author: Tulchinsky, Theodore H. title: Expanding the Concept of Public Health date: 2014-10-10 words: 33923 flesch: 39 summary: In 1920, C. E. A. Winslow, professor of public health at Yale University, defined public health as follows: Public health is the Science and Art of (1) preventing disease, (2) prolonging life, and (3) Winslow's far-reaching definition remains a valid framework but is unfulfilled when clinical medicine and public health have financing and management barriers between them. The evolution of concepts of public health will have to address these new challenges of population health. keywords: action; approach; century; community health; conditions; control; countries; development; disease; environment; factors; groups; health; health care; health insurance; health issues; health promotion; health services; health status; health systems; individual; life; management; medical; mortality; national; needs; new; people; policy; population; population health; prevention; primary; programs; public; quality; resources; risk; social; world cache: cord-303165-ikepr2p2.txt plain text: cord-303165-ikepr2p2.txt item: #86 of 115 id: cord-304492-ntme8w6i author: None title: Speaking up against inequity and racism date: 2020-06-16 words: 1425 flesch: 46 summary: Among other efforts by the American Association for Cancer Research, the 2020 by 2020 initiative aims to address cancer disparities in the African-American population by collecting genomic and clinical data from 2020 African-American patients with cancer. Nat Cancer DOI: 10.1038/s43018-020-0091-x sha: doc_id: 304492 cord_uid: ntme8w6i Inequalities are prevalent across the spectrum of cancer research and patient care, with destructive repercussions for people and society. keywords: cancer; health; population; research cache: cord-304492-ntme8w6i.txt plain text: cord-304492-ntme8w6i.txt item: #87 of 115 id: cord-305303-82n96ukr author: Shapira, Assaf title: Removal of Hepatitis C Virus-Infected Cells by a Zymogenized Bacterial Toxin date: 2012-02-16 words: 10191 flesch: 37 summary: These zymoxins showed a higher level of cytotoxicity when applied to NS3 expressing cells or to HCV infected cells, demonstrating a potential therapeutic window. To evaluate the potential of the NS3-cleavable MazF based zymoxin in eradication of NS3 expressing cells, three 96 well plates were seeded with Tet-inducible full NS3-4A, Tet-NS3/activated MazF or Tet-NS3/uncleavable MazF cells and were supplemented with 3 fold serial dilutions of tetracycline starting with 1000 ng/ ml. keywords: cells; encoding; hcv; infected; mazf; mazf cells; mcherry; ns3; peptide; protease; protein; tet; toxin; uncleavable; uncleavable mazf; virus; zymoxin cache: cord-305303-82n96ukr.txt plain text: cord-305303-82n96ukr.txt item: #88 of 115 id: cord-305858-gp1u4kh7 author: Song, Xiang title: High expression of angiotensin-converting enzyme-2 (ACE2) on tissue macrophages that may be targeted by virus SARS-CoV-2 in COVID-19 patients date: 2020-07-19 words: 4909 flesch: 42 summary: The data suggests that SARS-CoV-2 virus may not directly attack blood immune cells lacking the ACE2 expression. To better understand the pathogenesis of COVID-19 and build up the host anti-viral immunity, we examined the levels of ACE2 expression on different types of immune cells including tissue macrophages. keywords: ace2; blood; cells; cov-2; covid-19; expression; figure; human; macrophages; sars; tissue; usa cache: cord-305858-gp1u4kh7.txt plain text: cord-305858-gp1u4kh7.txt item: #89 of 115 id: cord-308328-wfiqbu3m author: Upadhyay, Ranjit Kumar title: Age-group-targeted testing for COVID-19 as a new prevention strategy date: 2020-09-01 words: 4794 flesch: 53 summary: Recently, some new approaches about age structure population models have been proposed in [9, 10] . We observe a common trend in infected age groups across all three countries, in that the young-and middleaged groups (between 10 and 40 years of age) have the largest numbers of infected people, relative to the initial susceptible population size of that age group. keywords: age; contact; disease; india; infection; lockdown; model; population cache: cord-308328-wfiqbu3m.txt plain text: cord-308328-wfiqbu3m.txt item: #90 of 115 id: cord-309379-ml75kvl5 author: Kanger, Laur title: Emergence, consolidation and dominance of meta-regimes: Exploring the historical evolution of mass production (1765–1972) from the deep transitions perspective date: 2020-09-09 words: 13232 flesch: 38 summary: shortage, road and rail networks, population growth, big corporations, rise of engineering, cultural values) set the stage for the emergence of mass production 1908-1919 Rules/regimes: alignment of various rules into mass production regime in the mobility system (Ford, USA) Meta-rules/meta-regimes: early experiments with mass production in food and defence systems (tractors, artillery shells), including some initial setbacks (submarine patrol boats) However, our analysis also revealed specific channels of early diffusion: 1) mass production was more likely to move from one location to another when the underlying systems were similar, e.g. the early adoption of US techniques by French car producers; 2) mass production was more likely to move from one system to another in a given location, e.g. an early extension of mass production to the food system in USA; 3) in different systems mass production was first more likely to be applied to similar technologies, e.g. the use of mechanized vehicles in the American food system preceding the standardization of tomatoes. keywords: american; case; dynamics; e.g.; ford; framework; mass; mass production; meta; new; phase; production; regime; rules; social; socio; systems; transitions; usa; use; war cache: cord-309379-ml75kvl5.txt plain text: cord-309379-ml75kvl5.txt item: #91 of 115 id: cord-309488-8guapzke author: Dodd, R. title: Other emerging viral pathogens date: 2006-08-15 words: 4368 flesch: 45 summary: Rabies virus infection is not thought to result in viraemia and it was considered likely that the transmission resulted from infection of, and via the sympathetic innervation of the transplanted organs. After the recognition of TTV, the search for hepatitis viruses continued, and Primi and colleagues keywords: blood; disease; hepatitis; infection; transfusion; transmission; virus; viruses cache: cord-309488-8guapzke.txt plain text: cord-309488-8guapzke.txt item: #92 of 115 id: cord-311214-eqwxkwqa author: Kumar, Roshan title: Comparative Genomic Analysis of Rapidly Evolving SARS-CoV-2 Viruses Reveal Mosaic Pattern of Phylogeographical Distribution date: 2020-04-16 words: 2731 flesch: 54 summary: 132 To determine the evolutionary pressure on viral proteins, dN/dS values were calculated for 9 134 ORFs of all strains. [36] and IntAct [37] for predicting their interaction against host proteins. keywords: cov-2; figure; isolates; proteins; sars; strains; usa cache: cord-311214-eqwxkwqa.txt plain text: cord-311214-eqwxkwqa.txt item: #93 of 115 id: cord-313821-5f5b107l author: Poelman, Randy title: The emergence of enterovirus D68 in a Dutch University Medical Center and the necessity for routinely screening for respiratory viruses date: 2014-11-15 words: 3040 flesch: 52 summary: key: cord-313821-5f5b107l authors: Poelman, Randy; Schölvinck, Elisabeth H.; Borger, Renze; Niesters, Hubert G.M.; van Leer-Buter, Coretta title: The emergence of enterovirus D68 in a Dutch University Medical Center and the necessity for routinely screening for respiratory viruses date: 2014-11-15 journal: J Clin Virol DOI: 10.1016/j.jcv.2014.11.011 sha: doc_id: 313821 cord_uid: 5f5b107l BACKGROUND: Since August 2014, an increase in infections caused by enterovirus D68 (EV-D68) was reported in the USA and Canada, for the most part in children presenting with severe respiratory symptoms. Since August 2014, an increase in infections caused by enterovirus D68 (EV-D68) has been reported in the USA and Canada. keywords: children; d68; enterovirus; hospital; infections; samples cache: cord-313821-5f5b107l.txt plain text: cord-313821-5f5b107l.txt item: #94 of 115 id: cord-316430-idjkqcee author: Costa, Kauê M. title: Short-term scholar visas are essential for science date: 2020-10-16 words: 895 flesch: 41 summary: Though temporary, the enacted suspensions may lead to a long-term disruption of scientific research in the US, much of which is crucial for public health and technological advancement. There are legitimate issues regarding the exploitation of short-term work visas and their recipients that should be addressed specifically, and while J-1 research scholars (the category encompassing most US postdoctoral researchers) are currently exempt from the proclamation, many scientists will still be affected. keywords: research; scientists; work cache: cord-316430-idjkqcee.txt plain text: cord-316430-idjkqcee.txt item: #95 of 115 id: cord-317583-jhulvfev author: Blanchflower, David G. title: Is happiness U-shaped everywhere? Age and subjective well-being in 145 countries date: 2020-09-09 words: 12067 flesch: 64 summary: These answers seem to be similar using happiness or life satisfaction data. Finally, I re-estimate the well-being equation and replace the age and age squared term with a complete set of single year of age variables which I then plot in a series of figures. keywords: age; controls; countries; country; data; evidence; happiness; life; minimum; satisfaction; shape; step; table; variables cache: cord-317583-jhulvfev.txt plain text: cord-317583-jhulvfev.txt item: #96 of 115 id: cord-318282-ocgfgx9r author: Boyce, John M title: Meticillin-resistant Staphylococcus aureus date: 2005-10-31 words: 8590 flesch: 41 summary: Despite the absence of extensive data, reports of recent percentages of up to 70% of nosocomial MRSA infections confirm the urgent need for an effective antimicrobial usage policy for our country. The main principles are promotion of hand disinfection, identification of MRSA risk patients (carriers and contacts of known MRSA cases), rapid microbiological identification of MRSA, contact isolation of MRSA cases, and treatment of MRSA infections. keywords: aureus; care; community; control; health; hospital; infections; methicillin; mrsa; patients; resistance; screening; staphylococcus; strains; surveillance; vancomycin cache: cord-318282-ocgfgx9r.txt plain text: cord-318282-ocgfgx9r.txt item: #97 of 115 id: cord-319884-d8n0aokl author: Natesan, Mohan title: Protein Microarrays and Biomarkers of Infectious Disease date: 2010-12-16 words: 7097 flesch: 31 summary: Drug Des Protein-protein interactions and selection: Array-based techniques for screening disease-associated biomarkers in predictive/early diagnosis Defining the humoral immune response to infectious agents using high-density protein microarrays Design of high-density antibody microarrays for disease proteomics: Key technological issues Extensive antibody cross-reactivity among infectious gram-negative bacteria revealed by proteome microarray analysis Analysis of the human immune response to vacccina by use of novel protein microarray suggests that antibodies recognize less than 10% of the total viral proteome Applications of protein microarrays for biomarker discovery Protein microarrays: High-throughput tools for proteomics Advances and perspectives in aptamer arrays Affibody molecules in protein capture microarrays: Evaluation of multidomain ligands and different detection formats Use of a single-chain antibody library for ovarian cancer biomarker discovery Reversephase protein microarrays: Application to biomarker discovery and translational medicine Development of reverse phase protein microarrays for clinical applications and patient-tailored therapy Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front Analysis of signaling pathways in 90 cancer cell lines by protein lysate array Reverse-phase protein lysate microarrays for cell signaling analysis Multiplex approaches in protein microarray technology Printing proteins as microarrays for high-throughput function determination Self-assembling protein microarrays Global analysis of protein activities using proteome chips Proteome-wide analysis of the serological response to vaccinia and smallpox Antibody profiling by proteome microarray reveals the immunogenicity of the attenuated smallpox vaccine modified vaccinia virus ankara is comparable to that of Dryvax A Burkholderia pseudomallei protein microarray reveals serodiagnostic and cross-reactive antigens Protein microarray for profiling antibody responses to Yersinia pestis live vaccine Serologic survey of the sentinel animals for plague surveillance and screening for complementary diagnostic markers to F1 antigen by protein microarray Antibody profiling in plague patients by protein microarray From protein microarrays to diagnostic antigen discovery: A study of the pathogen Francisella tularensis Immunodominant Francisella tularensis antigens identified using proteome microarray Candidate antigens for Q fever serodiagnosis revealed by immunoscreening of a Coxiella burnetii protein microarray Large scale immune profiling of infected humans and goats reveals differential recognition of Brucella melitensis antigens A genome-wide proteome array reveals a limited set of immunogens in natural infections of humans and white-footed mice with Borrelia burgdorferi Genome-wide study of Pseudomonas aeruginosa outer membrane protein immunogenicity using self-assembling protein microarrays Bacterial protein microarrays for identification of new potential diagnostic markers for Neisseria meningitidis infections Analysis of phagosomal proteomes: From latex-bead to bacterial phagosomes Anthrax infection inhibits the AKT signaling involved in the E-cadherin-mediated adhesion of lung epithelial cells Capturing host-pathogen interactions by protein microarrays: Identification of novel streptococcal proteins binding to human fibronectin, fibrinogen, and C4BP Profiling the humoral immune response to infection by using proteome microarrays: high-throughput vaccine and diagnostic antigen discovery Identification of humoral immune responses in protein microarrays using DNA microarray data analysis techniques Single step generation of protein arrays from DNA by cell-free expression and in situ immobilisation (PISA method) Distinct formats of protein microarrays have been developed for different applications, including abundance-based and function-based methods. keywords: analysis; antibodies; antibody; antigens; binding; detection; human; infection; interactions; methods; microarrays; protein; proteome; responses; study; use; vaccinia; virus cache: cord-319884-d8n0aokl.txt plain text: cord-319884-d8n0aokl.txt item: #98 of 115 id: cord-321346-epsp3bbm author: Luppa, Peter B. title: Point-of-care testing (POCT): Current techniques and future perspectives date: 2011-03-21 words: 4896 flesch: 46 summary: In the past few years, the market for POCT systems grew yearly by more than 10%, but this rapid growth has been slightly dampened since 2007. Type 5 -Continuous measurement with POCT systems. keywords: analysis; blood; care; detection; laboratory; patient; poct; results; sample; systems; testing; time; usa; use cache: cord-321346-epsp3bbm.txt plain text: cord-321346-epsp3bbm.txt item: #99 of 115 id: cord-321800-0h28pg3b author: Klingelhöfer, Doris title: Coronavirus: An insight into global research until outbreak of COVID-19 and its implications for the future date: 2020-09-23 words: 6123 flesch: 51 summary: During this period, the affected nations seem to have created an awareness of the importance of SARS research and the international interest in CoV research that responds to it. The financing of CoV research is also picking up speed. keywords: articles; cases; countries; cov; mers; number; publication; research; sars cache: cord-321800-0h28pg3b.txt plain text: cord-321800-0h28pg3b.txt item: #100 of 115 id: cord-325484-bd6ba0cp author: Johnstone, Phil title: World wars and the age of oil: Exploring directionality in deep energy transitions date: 2020-09-04 words: 13107 flesch: 46 summary: Building on the DT framework and the recognition of the key rule of maintaining abundant and constant supply during world wars [27] , we build on diverse literatures to build an interpretive account of how the exceptional demand pressures of total war influenced dynamics in multiple sociotechnical systems and the relevance these changes had for oil transitions. First, we look at events in the First World War in the UK and USA and identify broad trends and geopolitical developments before discussing illustrative examples of relevant developments related to energy, food, and mobility for considering oil transitions. keywords: age; analysis; coal; demand; developments; energy; energy transitions; europe; focus; framework; industry; oil; oil transitions; role; systems; transitions; usa; war ii; wars; world war cache: cord-325484-bd6ba0cp.txt plain text: cord-325484-bd6ba0cp.txt item: #101 of 115 id: cord-326189-41t2sshy author: García-Colón, Ismael title: The COVID-19 spring and the expendability of guestworkers date: 2020-07-29 words: 3528 flesch: 42 summary: Meanwhile, in the USA, the Trump Administration is increasing the rhetoric of nativism and pandemic to implement aggressive immigration bans that affect other industries and arguing that these policies benefit US workers by reducing job competition from immigrants. If the supply of local workers available to work under the wage and conditions set forth by growers and government officials was insufficient, the US Department of Labor certified the use of guestworkers. keywords: covid-19; employers; farmworkers; government; guestworkers; labor; usa; workers; working cache: cord-326189-41t2sshy.txt plain text: cord-326189-41t2sshy.txt item: #102 of 115 id: cord-328865-ekgqdjlk author: Anand, Shuchi title: Prevalence of SARS-CoV-2 antibodies in a large nationwide sample of patients on dialysis in the USA: a cross-sectional study date: 2020-09-25 words: 5654 flesch: 36 summary: We also harnessed population data on SARS-CoV-2 cases and deaths and percentage testing positive using nasal swab testing to assess how seroprevalence estimates correlated with other epidemiological measures of COVID-19 incidence. To our knowledge, we provide the first nationally representative estimate of SARS-CoV-2 seroprevalence in the US dialysis and US adult population, and estimates for differences in seroprevalence by neighbourhood race and ethnicity, poverty, population density, and mobility restriction. keywords: cov-2; covid-19; data; dialysis; level; patients; people; population; race; sars; seroprevalence; testing cache: cord-328865-ekgqdjlk.txt plain text: cord-328865-ekgqdjlk.txt item: #103 of 115 id: cord-331354-ungzlp6b author: Mimkes, J. title: Test-adjusted results of mortality for Covid-19 in Germany, USA, UK date: 2020-11-04 words: 1555 flesch: 68 summary: In a pandemic, two time series are generally reported: the time series of daily infections (I k), and the time series for daily deaths (D k), as provided by the Johns-Hopkins-University (JHU) in USA and the Robert-Koch-Institute (RKI) in Germany. The series of daily registered new infections (I k) and the series of daily deaths (D k) are given in figs. keywords: deaths; preprint cache: cord-331354-ungzlp6b.txt plain text: cord-331354-ungzlp6b.txt item: #104 of 115 id: cord-333599-hl11ln2r author: Tulchinsky, Theodore H. title: Planning and Managing Health Systems date: 2014-10-10 words: 19702 flesch: 36 summary: Lobbying on the part of professional or lay groups for particular interests they wish to promote is part of the process of policy formulation and has an important role in the planning and management of health care systems. Many of the components that are available in health care systems exist, while others that remain to be developed are discussed. keywords: approach; change; community; countries; development; goals; health; health care; health systems; hospital; human; individual; management; national; needs; new; objectives; organization; people; planning; policy; population; program; public; quality; resources; services; systems; theory; work; workers cache: cord-333599-hl11ln2r.txt plain text: cord-333599-hl11ln2r.txt item: #105 of 115 id: cord-336012-8klkojpo author: Harilal, Divinlal title: SARS-CoV-2 Whole Genome Amplification and Sequencing for Effective Population-Based Surveillance and Control of Viral Transmission date: 2020-06-18 words: 3042 flesch: 36 summary: Results We show a significant improvement in whole genome sequencing data quality and viral detection using amplicon-based target enrichment of SARS-CoV-2. Even with higher throughput sequencing (NovaSeq SP flowcell), shotgun sequencing requires an allocation of 1TB of data for ~250 sequenced samples. keywords: cost; cov-2; data; genome; sars; sequencing; table; usa; virus cache: cord-336012-8klkojpo.txt plain text: cord-336012-8klkojpo.txt item: #106 of 115 id: cord-342242-cynpob7b author: Godakova, Svetlana A. title: Camelid VHHs Fused to Human Fc Fragments Provide Long Term Protection Against Botulinum Neurotoxin A in Mice date: 2019-08-07 words: 7535 flesch: 48 summary: A light chain from a macaque immune library Role of homologous Fc fragment in the potency and efficacy of anti-botulinum antibody preparations Monoclonal antibodies to type A, B, E and F botulinum neurotoxins Selection and identification of single domain antibody fragments from camel heavy-chain antibodies Basics of antibody phage display technology Multi-subunit proteins on the surface of filamentous phage: Methodologies for displaying antibody (Fab) heavy and light chains Botulinum Toxoid Vaccine for Workers at Risk for Occupational Exposure to Botulinum Toxins Clostridium botulinum-International Programme on Chemical Safety-Bacteria; World Health Organization Current strategies for designing antidotes against botulinum neurotoxins Neutralizing antibodies of botulinum neurotoxin serotype A screened from a fully synthetic human antibody phage display library The European AntibotABE Framework Program and its update: Development of innovative botulinum antibodies Hammers, R. Naturally-occurring antibodies devoid of light-chains Properties, production, and applications of camelid single-domain antibody fragments Single domain antibodies: Promising experimental and therapeutic tools in infection and immunity Nanobodies: Natural single-domain antibodies Single-Domain Antibodies as therapeutics against human viral diseases Development of antiricin single domain antibodies toward detection and therapeutic reagents Genetic passive immunization with adenoviral vector expressing chimeric nanobody-Fc molecules as therapy for genital infection caused by Mycoplasma hominis Increasing the potency of neutralizing single-domain antibodies by functionalization with a CD11b/CD18 binding domain Selection of nanobodies that block the enzymatic and cytotoxic activities of the binary Clostridium difficile toxin Camelid single-domain antibodies (VHHs) against Crotoxin: A basis for developing modular building blocks for the enhancement of treatment or diagnosis of crotalic envenoming Structural basis for the specific neutralization of Stx2a with a camelid single domain antibody fragment A single-domain llama antibody potently inhibits the enzymatic activity of botulinum neurotoxin by binding to the non-catalytic α-exosite binding region Botulinum neurotoxins and botulism: A novel therapeutic approach Camelid single-domain antibodies: Historical perspective and future outlook Current approaches and future perspectives for nanobodies in stroke diagnostic and therapy Fusion of hIgG1-Fc to 111In-anti-amyloid single domain antibody fragment VHH-pa2H prolongs blood residential time in APP/PS1 mice but does not increase brain uptake Prolonged prophylactic protection from botulism with a single adenovirus treatment promoting serum expression of a VHH-based antitoxin protein Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin Beyond binding: Antibody effector functions in infectious diseases Botulinum neurotoxins: Biology, pharmacology, and toxicology The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity Human IgG subclass cross-species reactivity to mouse and cynomolgus monkey Fcγ receptors Differential tumor-targeting abilities of three single-domain antibody formats Characterization of neutralizing antibodies and identification of neutralizing epitope mimics on the Clostridium botulinum neurotoxin type A Potent neutralization of botulinum neurotoxin by recombinant oligoclonal antibody Characterization of botulinum neurotoxin type A neutralizing monoclonal antibodies and influence of their half-lives on therapeutic activity Characterization of the monoclonal antibody response to botulinum neurotoxin type A in the complexed and uncomplexed forms Development of germline-humanized antibodies neutralizing botulinum neurotoxin A and B Llama-derived single-domain antibodies for the detection of botulinum A neurotoxin Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases Antigen recognition by single-domain antibodies: Structural latitudes and constraints Single-domain antibodies and their formatting to combat viral infections Engineered antibody fragments and the rise of single domains Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection A novel nanobody targeting middle east respiratory syndrome coronavirus (MERS-CoV) receptor-binding domain has potent cross-neutralizing activity and protective efficacy against MERS-CoV Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21 Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin Neutralization of Clostridium difficile toxin B with VHH-Fc fusions targeting the delivery and CROPs domains Efficient serum clearance of botulinum neurotoxin achieved using a pool of small antitoxin binding agents Development of neutralizing scFv-Fc against botulinum neurotoxin keywords: antibodies; antibody; b11; bont; botulinum; clones; domain; dtt; mice; neurotoxin; toxin; usa; vhhs cache: cord-342242-cynpob7b.txt plain text: cord-342242-cynpob7b.txt item: #107 of 115 id: cord-343740-vcys2q2t author: Kawachi, Ichiro title: COVID-19 and the ‘rediscovery’ of health inequities date: 2020-09-24 words: 2376 flesch: 47 summary: When future historians look back on the dismal performance of unequal societies during the Covid-19 pandemic, they will conclude that their leaders were too slow to implement public health measures, and too hasty in loosening them. Likewise, health inequalities have been evident since the beginning of public record keeping-q.v. keywords: covid-19; health; infection; pandemic; people; usa; work cache: cord-343740-vcys2q2t.txt plain text: cord-343740-vcys2q2t.txt item: #108 of 115 id: cord-345430-yowyy5nr author: Balzano, Francesca title: Behavioral Changes in Stem-Cell Potency by HepG2-Exhausted Medium date: 2020-08-12 words: 5498 flesch: 47 summary: In particular, stem cells from Wharton jelly (WJ-MSCs) represent a valuable model of these multipotent cells, and can be easily obtained without ethical issues [2, 3] . [47] , considered as a reference gene, while the gene levels of stem cells were expressed as fold-change (2−∆∆Ct) relative to the gene levels observed when stem cells reached 80% confluence before starting treatment. keywords: cells; control; expression; figure; gapdh; hepg2; medium; mscs; myc; sirt1; stem; usa cache: cord-345430-yowyy5nr.txt plain text: cord-345430-yowyy5nr.txt item: #109 of 115 id: cord-345524-vre54bq9 author: Groneberg, David A. title: Needlestick injuries: a density-equalizing mapping and socioeconomic analysis of the global research date: 2020-05-05 words: 4165 flesch: 47 summary: Since there are no data existing on the international architecture of NSI research available, the present study used the NewQIS project platform (Groneberg-Kloft et al. 2009a) to construct the first picture of global NSI research strategies. Albeit NSI research activity is generally increasing, the growth is asymmetrical from a global viewpoint. keywords: analysis; articles; countries; country; global; health; nsi; research cache: cord-345524-vre54bq9.txt plain text: cord-345524-vre54bq9.txt item: #110 of 115 id: cord-346185-qmu1mrmx author: Velásquez, Ricardo Manuel Arias title: Forecast and evaluation of COVID-19 spreading in USA with Reduced-space Gaussian process regression date: 2020-05-22 words: 1125 flesch: 46 summary: key: cord-346185-qmu1mrmx authors: Velásquez, Ricardo Manuel Arias; Lara, Jennifer Vanessa Mejia title: Forecast and evaluation of COVID-19 spreading in USA with Reduced-space Gaussian process regression date: 2020-05-22 journal: Chaos Solitons Fractals DOI: 10.1016/j.chaos.2020.109924 sha: doc_id: 346185 cord_uid: qmu1mrmx In this report, we analyze historical and forecast infections for COVID-19 death based on Reduced-Space Gaussian Process Regression associated to chaotic Dynamical Systems with information obtained in 82 days with continuous learning, day by day, from January 21(th), 2020 to April 12(th). Late on January, USA confirmed the first patient with COVID-19, who had recently traveled to China, however, an evaluation of states in USA have demonstrated a fatality rate in China (4%) is lower than New York (4.56%), but lower than Michigan (5.69%). keywords: covid-19; process; usa cache: cord-346185-qmu1mrmx.txt plain text: cord-346185-qmu1mrmx.txt item: #111 of 115 id: cord-347053-m5m4zgfy author: Pharo, Elizabeth A. title: Host–Pathogen Responses to Pandemic Influenza H1N1pdm09 in a Human Respiratory Airway Model date: 2020-06-24 words: 9497 flesch: 40 summary: The interaction between respiratory pathogens and mucus Muc5b is required for airway defence The frontline defence of the lung Clinical aspects and cytokine response in severe H1N1 influenza A virus infection Influenza H5N1 and H1N1 virus replication and innate immune responses in bronchial epithelial cells are influenced by the state of differentiation Intensive cytokine induction in pandemic H1N1 influenza virus infection accompanied by robust production of IL-10 and IL-6 Influenza virus damages the alveolar barrier by disrupting epithelial cell tight junctions Cytokine responses in patients with mild or severe influenza A(H1N1)pdm09 Inflammatory responses in influenza A virus infection The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts Genenames.org: The HGNC and VGNC resources in 2019 Rhinovirus-induced barrier dysfunction in polarized airway epithelial cells is mediated by NADPH oxidase 1 Innate immune recognition in infectious and noninfectious diseases of the lung Innate immunity in the lung: How epithelial cells fight against respiratory pathogens Collectins and cationic antimicrobial peptides of the respiratory epithelia Structure and function of the polymeric mucins in airways mucus Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway A review of inflammatory mechanism in airway diseases Respiratory epithelial cells as master communicators during viral infections Airway epithelial differentiation and mucociliary clearance Identification and functions of pattern-recognition receptors Pattern recognition receptors and inflammation Toll-like receptors and their crosstalk with other innate receptors in infection and immunity Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses Influenza virus activation of the interferon system The innate immune function of airway epithelial cells in inflammatory lung disease Respiratory epithelial cells in innate immunity to influenza virus infection A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape Interferon-stimulated genes: A complex web of host defenses Induction and evasion of type I interferon responses by influenza viruses Interferon-stimulated genes: What do they all do? Delayed clearance of viral load and marked cytokine activation in severe cases of pandemic H1N1 2009 influenza virus infection Cytokine and chemokine profiles in lung tissues from fatal cases of 2009 pandemic influenza A (H1N1): Role of the host immune response in pathogenesis Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza Integrated analysis of microRNA-mRNA expression in A549 cells infected with influenza A viruses (IAVs) from different host species IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications Synergistic up-regulation of CXCL10 by virus and IFN gamma in human airway epithelial cells Innate immune response to H3N2 and H1N1 influenza virus infection in a human lung organ culture model Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infection Modulating the innate immune response to influenza A virus: Influenza A viruses damage apical junctional complexes and alter the cell cytoskeleton and morphology of airway epithelial cells [34, 35, 83] . keywords: airway; cells; epithelium; expression; figure; h1n1pdm09; human; iav; infection; influenza; mock; pandemic; poly(i; response; teer; virus; vitro; wdnhbe cache: cord-347053-m5m4zgfy.txt plain text: cord-347053-m5m4zgfy.txt item: #112 of 115 id: cord-350379-6l55soxu author: Lee, Jenny J. title: Scientific globalism during a global crisis: research collaboration and open access publications on COVID-19 date: 2020-07-24 words: 6228 flesch: 33 summary: It may be for this reason that less-resourced countries are more likely to be involved in international research collaboration than independent research (Pouris & Ho, 2016; Iglic, Doreian, Kronegger, & Ferligoj, 2017) . Toward a model of collaboration propensity The geopolitics of academic science Unseen workers in the academic factory: perceptions of neo-racism among international postdocs in the US and UK A bibliometric analysis of COVID-19 research activity: A call for increased output Open access archiving: the fast track to building research capacity in developing countries Humanity wins: our fight to unlock 32,544 COVID-19 articles for the world New approach to the visualization of international scientific collaboration Bibliometric analysis of severe acute respiratory syndrome-related research in the beginning stage Evolution and convergence of the patterns of international scientific collaboration Coronavirus Drives the U.S. and China Deeper Into Global Power Struggle Bibliometric analysis of global scientific research on coronavirus (COVID-19) keywords: access; articles; china; collaboration; countries; country; covid-19; covid-192020; publications; research; science; study cache: cord-350379-6l55soxu.txt plain text: cord-350379-6l55soxu.txt item: #113 of 115 id: cord-350956-ytcwt9qk author: Smith, K. M. title: Summarizing US Wildlife Trade with an Eye Toward Assessing the Risk of Infectious Disease Introduction date: 2017-02-07 words: 5507 flesch: 44 summary: Most regulatory oversight of wildlife trade is aimed at conservation, rather than prevention of disease introduction. Wildlife trade is one of the largest and most complex commerce exchanges in the world. keywords: animals; data; imports; majority; products; shipments; species; trade; usa; usfws; wildlife cache: cord-350956-ytcwt9qk.txt plain text: cord-350956-ytcwt9qk.txt item: #114 of 115 id: cord-351666-q7dqsl7n author: Milani, Fabio title: COVID-19 outbreak, social response, and early economic effects: a global VAR analysis of cross-country interdependencies date: 2020-08-19 words: 9184 flesch: 50 summary: Social distancing responses to domestic and global health shocks are heterogeneous; however, they almost always exhibit delays and sluggish adjustments. Gupta and et al. (2020) find that social distancing responses do not necessarily correspond to policies mandated by State and local governments. keywords: cases; coronavirus; countries; country; covid-19; data; distancing; global; mobility; perceptions; responses; risk; unemployment; variables cache: cord-351666-q7dqsl7n.txt plain text: cord-351666-q7dqsl7n.txt item: #115 of 115 id: cord-352824-sbsg39ix author: Zhan, Choujun title: General Model for COVID-19 Spreading with Consideration of Intercity Migration, Insufficient Testing and Active Intervention: Application to Study of Pandemic Progression in Japan and USA date: 2020-03-30 words: 6640 flesch: 48 summary: j I j,0 : initial number of infected individuals in region j E j,0 : initial number of individuals in region j C j,0 : initial number of confirmed infected individuals in region j The model integrates intercity travel data to track the movement of exposed and infected individuals among cities, and allows different levels of active intervention to be considered so that realistic prediction of the number of infected individuals can be performed. keywords: cases; individuals; intervention; model; number; population cache: cord-352824-sbsg39ix.txt plain text: cord-352824-sbsg39ix.txt