        item: #1 of 68
          id: cord-004297-rm0zbgfm
      author: Hemilä, Harri
       title: Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis
        date: 2020-02-07
       words: 5045
      flesch: 51
     summary: A meta-analysis of vitamin C effect on exercise-induced bronchoconstriction found that vitamin C halved FEV 1 decline caused by exercise key: cord-004297-rm0zbgfm authors: Hemilä, Harri; Chalker, Elizabeth title: Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis date: 2020-02-07 journal: J Intensive Care DOI: 10.1186/s40560-020-0432-y sha: doc_id: 4297 cord_uid: rm0zbgfm BACKGROUND: Our recent meta-analysis indicated that vitamin C may shorten the length of ICU stay and the duration of mechanical ventilation.
    keywords: analysis; meta; patients; trials; ventilation; vitamin; vitamin c
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        item: #2 of 68
          id: cord-005428-pm7ihh9t
      author: Amrein, Karin
       title: Vitamin D deficiency 2.0: an update on the current status worldwide
        date: 2020-01-20
       words: 6968
      flesch: 34
     summary: Trends in the incidence of testing for vitamin D deficiency in primary care in the UK: a retrospective analysis of The Health Improvement Network (THIN) Vitamin D deficiency in Europe: pandemic? Association between vitamin D supplementation and mortality: systematic review and meta-analysis When not to use metaanalysis: analysing the meta-analyses on vitamin D in critical care Vitamin D and energy homeostasis: of mice and men Vitamin D supplementation and prevention of type 2 diabetes Vitamin D supplements and prevention of cancer and cardiovascular disease Why secondary analyses in vitamin d clinical trials are important and how to improve vitamin d clinical trial outcome analyses-a comment on Extra-Skeletal Effects of Vitamin D The effect of high-dose cholecalciferol on bioavailable vitamin D levels in critically ill patients: a post hoc analysis of the VITdAL-ICU trial Vitamin D status in critically ill patients: the evidence is now bioavailable! Immunomodulatory effect of vitamin D and its potential role in the prevention and treatment of type 1 diabetes mellitus-a narrative review Enhanced excretion of vitamin D binding protein in type 1 Vitamin D deficiency 2.0: an update on the current status worldwide diabetes: a role in vitamin D deficiency? Association of vitamin d with insulin resistance and β-Cell dysfunction in subjects at risk for type 2 diabetes Rationale and design of Diabetes Prevention with active Vitamin D (DPVD): a randomised, double-blind, placebocontrolled study Development of vitamin D toxicity from overcorrection of vitamin D deficiency: a review of case reports Mutations in CYP24A1 and Idiopathic Infantile Hypercalcemia Early high-dose vitamin D3 for critically Ill, vitamin D-deficient patients Effect of high-dose vitamin D3 on hospital length of stay in critically Ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial
    keywords: 25(oh)d; deficiency; diabetes; dose; levels; mortality; risk; supplementation; trial; vitamin
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        item: #3 of 68
          id: cord-006636-xgikbdns
      author: Ühlein, E.
       title: Übersicht Über neue ernährungswissenschaftliche Publikationen
        date: 1964-02-01
       words: 31083
      flesch: 47
     summary: im Liehte der mathematisehen Analyse der Bestimmungen der Fleischbcschau yon Schweinefleisch mSglieh? zur Bestimmung der Gesamtjodzahl yon
    keywords: 1963; absorption; abstr; acid; acid composition; acid metabolism; activity; amino; amino acid; analysis; arch; auf; beef; bei; bei der; bestimmung; blood; body; calcium; carbohydrate; changes; chemical; chick; children; cholesterol; comparison; composition; content; corn; cows; dairy; deficiency; den; der; des; determination; development; die; diet; digestibility; effect; egg; energy; ern; evaluation; excretion; factors; fat; fats; fatty; fed; feeding; feeds; fiber; fish; flour; food; fruit; glucose; growth; hrung; human; influence; intake; iron; lebensmittel; levels; lipids; liver; low; magnesium; malnutrition; meat; metabolism; method; milch; milk; nitrogen; nutrient; nutrition; nutritive; oil; performance; phosphorus; pigs; plant; plasma; potassium; poultry; production; products; protein; quality; r. s.; rats; relation; relationship; requirements; residues; response; s. s.; serum; sheep; sodium; storage; studies; study; temperature; tissue; und; untersuchungen; use; utilization; value; van; vitamin; water; wheat; wirkung; wiss; yon; zinc; zum; zur
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        item: #4 of 68
          id: cord-010443-4jblod8j
      author: Meduri, Gianfranco Umberto
       title: General Adaptation in Critical Illness: Glucocorticoid Receptor-alpha Master Regulator of Homeostatic Corrections
        date: 2020-04-22
       words: 18853
      flesch: 10
     summary: Timeliness of corticosteroid use in icu patients with pneumonia and ards Efficacy of corticosteroids in acute respiratory distress syn-drome: an observational study early administration of hydrocortisone replacement after the advent of septic shock: impact on survival and immune response * Early initiation of low-dose corticosteroid therapy in the management of septic shock: a retrospective observational study Glucocorticoid treatment in community-acquired pneumonia Hydrocortisone plus fludrocortisone for adults with septic shock Immune effects of corticosteroids in sepsis Vasopressin deficiency contributes to the vasodilation of septic shock Circulating vasopressin levels in septic shock Dieter ayers for the, and I. Septic shock trial, interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock The Australian-New Zealand intensive care society clinical trials, adjunctive glucocorticoid therapy in patients with septic shock Successful treatment of acute lung injury with pitavastatin in septic mice: potential role of glucocorticoid receptor expression in alveolar macrophages Influence of drug treatment on glucocorticoid receptor levels in patients with coronary heart disease Mechanistic insights into the protective impact of zinc on sepsis The protection potential of antioxidant vitamins against acute respiratory distress syndrome: a rat trial An historical review of glucocorticoid treatment in sepsis. The role and effects of glucocorticoid-induced leucine zipper in the context of inflammation resolution Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes Glucocorticoid-mediated regulation of granulocyte apoptosis and macrophage phagocytosis of apoptotic cells: implications for the resolution of inflammation Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophages Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytes Saturated-efferocytosis generates pro-resolving CD11blow macrophages: Modulation by resolvins and glucocorticoids Local amplification of glucocorticoids by 11 betahydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes Local amplification of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 and its role in the inflammatory response Glucocorticoids promote survival of anti-inflammatory macrophages via stimulation of adenosine receptor A3 Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide Ac(2-26) New lives given by cell death: macrophage differentiation following their encounter with apoptotic leukocytes during the resolution of inflammation Glucocorticoid resistance as a major drive in sepsis pathology Systemic inflammation-associated glucocorticoid resistance and outcome of ARDS Adrenal function and dysfunction in critically ill patients Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: a mechanism for the generation of glucocorticoid resistance Expression of the glucocorticoid receptor is decreased in experimental Staphylococcus aureus sepsis Cecal ligation and puncture alters glucocorticoid receptor expression Down regulation of hepatic glucocorticoid receptors after endotoxin treatment Nitric oxide up-regulates the glucocorticoid receptor and blunts the inflammatory reaction in porcine endotoxin sepsis Effects of different doses of hydrocortisone on acute lung injury in rats with early septic shock Glucocorticoid receptor expression on acute lung injury induced by endotoxin in rats Endothelial glucocorticoid receptor is required for protection against sepsis Modulation of glucocorticoid receptor expression, inflammation, and cell apoptosis in septic guinea pig lungs using methylprednisolone Low-dose dexamethasone alleviates lipopolysaccharide-induced acute lung injury in rats and upregulates pulmonary glucocorticoid receptors Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock Decreased cytosolic glucocorticoid receptor levels in critically ill patients Glucocorticoid receptor mRNA levels are selectively decreased in neutrophils of children with sepsis Reduced glucocorticoid receptor protein expression in children with critical illness Corticosteroid resistance in sepsis is influenced by microRNA-124-induced downregulation of glucocorticoid receptor-alpha Tissue mRNA expression of the glucocorticoid receptor and its splice variants in fatal critical illness An expanded definition of the adult respiratory distress syndrome Endothelial response to glucocorticoids in inflammatory diseases Dexamethasone potentiates in vitro blood-brain barrier recovery after primary blast injury by glucocorticoid receptor-mediated upregulation of ZO-1 tight junction protein Endothelial biomarkers in human sepsis: pathogenesis and prognosis for ARDS Dysregulation of the angiopoietin-Tie-2 axis in sepsis ARDS Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis Endothelial activation and blood-brain barrier injury as risk factors for Delirium in critically Ill patients Vitamin C revisited Microcirculatory alterations: potential mechanisms and implications for therapy.
    keywords: acid; activation; acute; ascorbic; cells; corrections; endothelial; expression; function; glucocorticoid; grα; human; illness; immune; inflammation; levels; mitochondria; mortality; nuclear; patients; receptor; response; role; sepsis; septic; shock; stress; tissue; transcription; treatment; vitamin
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        item: #5 of 68
          id: cord-013342-vx3eor43
      author: Silwal, Prashanta
       title: Nuclear Receptors as Autophagy-Based Antimicrobial Therapeutics
        date: 2020-08-27
       words: 7670
      flesch: 19
     summary: Nuclear receptors (NRs) are a family of transcriptional factors that regulate the expression of gene sets involved in, for example, metabolic and immune homeostasis. These NRs include the vitamin D receptor (VDR), also known as nuclear receptor subfamily 1, group I, member 1 (NR1I1)
    keywords: activation; antimicrobial; autophagy; cells; estrogen; expression; host; infection; nrs; orphan; receptor; regulation; responses; rev; signaling; vdr; vitamin
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        item: #6 of 68
          id: cord-016009-qa7bcsbu
      author: Starkel, Julie L.
       title: Respiratory
        date: 2019-10-07
       words: 22281
      flesch: 42
     summary: In Europe, lung disease represents 15% of all deaths -the fourth leading cause. Added together, lung disease rivals the position for the top cause of death.
    keywords: acid; antioxidant; asthma; body; cancer; cells; children; chronic; copd; deficiency; diet; disease; exposure; fibrosis; function; glutathione; health; immune; inflammation; intake; iron; levels; liver; low; lung; lung cancer; lung disease; patients; pulmonary; research; risk; role; status; stress; study; symptoms; tissue; treatment; vitamin
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        item: #7 of 68
          id: cord-016130-5q9ufu28
      author: Linday, Linda A.
       title: Nutritional Supplements and Upper Respiratory Tract Illnesses in Young Children in the United States
        date: 2010-12-17
       words: 11346
      flesch: 37
     summary: The New York Times Mercury and fish oil supplements; Letter Increased mortality in children with mild vitamin A deficiency Dorland's Illustrated Medical Dictionary Vitamin A and retinoids: an update of biological aspects and clinical applications Vitamin A supplementation: implications for morbidity and mortality in children Vitamin A supplementation in infectious diseases: a meta-analysis Vitamin A supplementation and childhood morbidity from diarrhea and respiratory infections: a meta-analysis A randomized, controlled trial of vitamin A in children with severe measles Vitamin A and retinoids in antiviral responses Vitamin A, infection, and immune function Vitamin A therapy for children with respiratory syncytial virus infection: a multicenter trial in the United States Treatment of respiratory syncytial virus infection with vitamin A: a randomized Vitamin A supplements ameliorate the adverse effect of HIV-1, malaria, and diarrheal infections on child growth Vitamin A supplements ameliorate the adverse effect of HIV-1, malaria, and diarrheal infections on child growth Dietary vitamin A intake and the risk of mortality among children Dietary vitamin A intake and the incidence of diarrhea and respiratory infection among Sudanese children Dietary vitamin A intake in relation to child growth Vitamin D analogues in insulin-dependent diabetes mellitus and other autoimmune diseases: a therapeutic perspective Comparison of the effects of 1,25-dihydroxyvitamin D3 on T lymphocyte subpopulations This chapter discusses the role of essential fatty acids, vitamins, and trace metals in the pathophysiology of inflammation; reviews our clinical research on the use of a lemon-flavored cod liver oil (which meets European purity standards) and a children's chewable multivitamin-mineral with Se for the prevention and adjunctive treatment of these disorders; reviews the history of cod liver oil, including its importance in the discovery of vitamin D and the anti-infective properties of vitamin A; and discusses the current clinical use of these supplements.
    keywords: children; cod; cod liver; fatty; fish; group; infections; liver; liver oil; oil; rickets; sinusitis; states; study; supplementation; supplements; treatment; united; use; vitamin
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        item: #8 of 68
          id: cord-017428-euzvhtax
      author: Janssens, Wim
       title: Vitamin D and Chronic Obstructive Pulmonary Disease
        date: 2012-02-17
       words: 8874
      flesch: 29
     summary: Vitamin D and health: perspectives from mice and man Vitamin D de fi ciency Vitamin D and human health: lessons from vitamin D receptor null mice Gene-environment interactions in chronic obstructive pulmonary disease Chronic obstructive pulmonary disease Projections of global mortality and burden of disease from 2002 to 2030 Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): a prespeci fi ed subgroup analysis of a randomised controlled trial Tiotropium as a fi rst maintenance drug in COPD: secondary analysis of the UPLIFT trial Chronic obstructive pulmonary disease: molecular and cellular mechanisms Antielastin autoimmunity in tobacco smoking-induced emphysema Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4+CD25+ regulatory T-lymphocyte response to tobacco smoking Alveolar macrophages as orchestrators of COPD Role of HDAC2 in the pathophysiology of COPD Schematic representation of potential relationship between vitamin D and COPD Defective macrophage phagocytosis of bacteria in COPD Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease COPD exacerbations: de fi ning their cause and prevention Effect of interactions between lower airway bacterial and rhinoviral infection in exacerbations of COPD New strains of bacteria and exacerbations of chronic obstructive pulmonary disease Airway bacterial concentrations and exacerbations of chronic obstructive pulmonary disease Susceptibility to exacerbation in chronic obstructive pulmonary disease COPD as a systemic disease Systemic effects of COPD COPD as a lung disease with systemic consequences-clinical impact, mechanisms, and potential for early intervention From COPD to chronic systemic in fl ammatory syndrome? Mortality in COPD: role of comorbidities Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism Vitamin D physiology Overview of general physiologic features and functions of vitamin D Identi fi cation and immune regulation of 25-hydroxyvitamin D-1-alpha-hydroxylase in murine macrophages Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts Genetics and biology of vitamin D receptor polymorphisms 13th workshop consensus for vitamin D nutritional guidelines Vitamin D de fi ciency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications Demographic differences and trends of vitamin D insuf fi ciency in the US population Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes Vitamin D toxicity, policy, and science Vitamin D beyond bones in chronic obstructive pulmonary disease: time to act IOM report sets new dietary intake levels for calcium and vitamin D to maintain health and avoid risks associated with excess Relationship between serum 25-hydroxyvitamin d and pulmonary function in the Third National Health and Nutrition Examination Survey Make no bones about it: increasing epidemiologic evidence links vitamin D to pulmonary function and COPD Smoking patterns in African Americans and whites with advanced COPD Common genetic determinants of vitamin D insuf fi ciency: a genome-wide association study Vitamin D binding protein variants and the risk of COPD Candidate genes for COPD in two large data sets Vitamin D de fi ciency, bone mineral density and weight in patients with advanced pulmonary disease Vitamin D de fi ciency is highly prevalent in COPD and correlates with variants in the vitamin D binding gene The vitamin D axis in the lung: a key role for vitamin D-binding protein Vitamin D-binding protein contributes to COPD by activation of alveolar macrophages Relationship of vitamin D status to adult lung function and COPD The coming of age of 1,25-dihydroxyvitamin D(3) analogs as immunomodulatory agents Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell pro fi le Evaluation of phagocytosis in rickets Control of Mycobacterium tuberculosis through mammalian Toll-like receptors High doses of vitamin D to reduce exacerbations in COPD: a randomized trial A 4-year trial of tiotropium in chronic obstructive pulmonary disease Combined salmeterol and fl uticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial Treatment of COPD: the sooner the better? Decreased histone deacetylase activity in chronic obstructive pulmonary disease VDR microRNA expression and epigenetic silencing of vitamin D signaling in melanoma cells DNA methylation-related vitamin D receptor insensitivity in breast cancer Vitamin D and susceptibility of chronic lung diseases: role of epigenetics Peripheral muscle weakness contributes to exercise limitation in COPD Pulmonary rehabilitation in chronic obstructive pulmonary disease Exercise training in COPD: how to distinguish responders from nonresponders Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 Vitamin D status predicts physical performance and its decline in older persons Effect of vitamin D on falls: a metaanalysis Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis Role of vitamin D in skeletal muscle function Osteomalacic myopathy Low-dose vitamin D prevents muscular atrophy and reduces falls and hip fractures in women after stroke: a randomized controlled trial Vitamin D and its role in skeletal muscle Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials Oxidative capacity of the skeletal muscle and lactic acid kinetics during exercise in normal subjects and in patients with COPD Muscle fi ber type IIX atrophy is involved in the loss of fat-free mass in chronic obstructive pulmonary disease Induction of speci fi c proteins in cultured skeletal muscle cells by 1,25-dihydroxyvitamin D-3 Analysis of the oxidative damage-induced conformational changes of apo-and holocalmodulin by dose-dependent protein oxidative surface mapping The effect of cholecalciferol in vivo on proteins and lipids of skeletal muscle from rachitic chicks Vitamin D and human skeletal muscle
    keywords: bone; ciency; copd; disease; exacerbations; function; levels; lung; muscle; osteoporosis; patients; pulmonary; vitamin; vitamin d
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        item: #9 of 68
          id: cord-017656-lqrkwlnb
      author: Lee, Wang Jae
       title: Common Cold and Flu
        date: 2019-08-07
       words: 3894
      flesch: 48
     summary: WT, normal mice group; Gulo(−/−), mice group which cannot produce vitamin C like humans; Gulo(−/−) + VC, Gulo(−/−) mice group fed with daily vitamin C in the drinking water Combined inhalational and oral supplementation of ascorbic acid may prevent influenza pandemic emergency: a hypothesis Vitamin C for preventing and treating the common cold Antiviral effects of ascorbic and dehydroascorbic acids in vitro Examining the evidence for the use of vitamin C in the prophylaxis and treatment of the common cold Vitamin C is an essential factor on the anti-viral immune responses through the production of interferon--α/β at the initial stage of influenza A virus (H3N2) infection Vitamin C deficiency increases the lung pathology of influenza viruainfected gulo(−/−) mice The role of cytokines in the immune response to influenza A virus infection Their conclusion is that vitamin C does not have a curative or preventive Vitamin C Against the Common Cold effect on colds but shortens the duration of the illness.
    keywords: air; cold; influenza; people; virus; vitamin; vitamin c
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        item: #10 of 68
          id: cord-018204-rqp4huk3
      author: Balan, K. V.
       title: Vitamin D and respiratory infections in infants and toddlers: a nutri-shine perspective
        date: 2013
       words: 6855
      flesch: 22
     summary: key: cord-018204-rqp4huk3 authors: Balan, K. V.; Babu, U. S.; Godar, D. E.; Calvo, M. S. title: Vitamin D and respiratory infections in infants and toddlers: a nutri-shine perspective date: 2013 journal: Handbook of vitamin D in human health DOI: 10.3920/978-90-8686-765-3_16 sha: doc_id: 18204 cord_uid: rqp4huk3 There is compelling evidence of a global problem of poor vitamin D status in expecting mothers and postnatal life; and even more critical, is the evidence showing the association of vitamin D deficiency with increased morbidity and mortality risks from respiratory infections. The impact of vitamin D on regulatory T cells High prevalence of moderately severe vitamin D deficiency in preterm infants Mother-child vitamin D deficiency: an international perspective Serum 25-hydroxyvitamin D and functional outcomes in the elderly Lung function prior to viral lower respiratory tract infections in prematurely born infants Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on cytokine production by human decidual cells The validity and practicality of sun-reactive skin types I through VI Maternal and fetal serum 1,25-dihydroxyvitamin D levels at term Lung mechanics in rachitic rats Relationship of viral infections to wheezing illnesses and asthma Fetomaternal vitamin D relationships at term UV doses of American children and adolescents Solar UV doses of young Americans and vitamin D3 production UV doses of Americans Prevalence of vitamin D deficiency among healthy infants and toddlers Vitamin D effects on lung immunity and respiratory diseases Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state The role of epithelial beta-defensins and cathelicidins in host defense of the lung Human perinatal vitamin D metabolism.
    keywords: 25(oh)d; age; children; deficiency; infants; infections; levels; lung; nmol; status; vitamin
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        item: #11 of 68
          id: cord-020493-ddo3a7wq
      author: None
       title: Infusionstherapie und Ernährung von Risikogruppen
        date: 2005
       words: 15028
      flesch: 37
     summary: Bei der Analyse der organischen Säuren im Urin findet man das für diese Krankheit typische Ausscheidungsmuster (⊡ Tabelle Die für die Behandlung notwendige Flüssigkeitsmenge richtet sich nach dem Dehydratationsgrad und ist abhängig vom Alter und von der Nierenfunktion des Patienten. Bei Neugeborenen ist die Vitaminkonzentration im Plasma abhängig ▬ von der Ernährung der Schwangeren (Baker et al. 1975) , ▬ vom plazentaren Transport und dem Geburtszeitpunkt (Tsang 1985 (Greene u. Smith 1993) , ▬ niedrige Körperspeicher (Baydas et al. 2002; Orzalesi 1987;
    keywords: 0,5; aber; acid; acyl; alle; als; aminosäuren; arthritis; auch; auf; aus; behandlung; bei; bei der; besteht; bis; blut; bone; bzw; ca-/p; calcium; chain; children; coa; daher; das; dass; defekt; deficiency; dehydrogenase; dem; der; des; die; dieser; disease; durch; eine; entwicklung; erkrankungen; ernährung; ersten; et al; etwa; findet; frühgeborenen; für; galactosemia; galaktosämie; infants; ist; ist die; jedoch; juvenile; kann; kg kg; kg und; kindern; klinische; kommt; können; liegt; man; mangel; mcad; metabolism; milk; mineral; mit; mit der; muss; nach; nahrung; neben; neugeborenen; nicht; nur; nutrition; oder; ohne; patienten; patients; preterm; regel; schon; sein; sich; sind; sollte; sowie; sowohl; supplementation; symptome; tabelle; tag; therapie; treatment; und; unter; urin; vitamin; von; von der; vor; werden; wird; zufuhr; zum; zur; zwischen; über
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        item: #12 of 68
          id: cord-026028-qj290zu6
      author: None
       title: Spezielle Arzneimitteltherapie in der Schwangerschaft
        date: 2008-12-10
       words: 80043
      flesch: 38
     summary: Eine spätere prospektive Untersuchung derselben Autorengruppe findet auch bei jenen Kindern, deren Mütter während der gesamten Schwangerschaft Trizyklika (46 Mutter-Kind-Paare; davon 36 bereits in der Studie von 1997 erfasst) genommen hatten, keine arzneispezifischen Auffälligkeiten in der Entwicklung der Kinder Unterschiede in der Entwicklung der Kinder bis zum 1.
    keywords: 100; 2000; 2003; 2005; aber; abschnitt; acid; acute; allerdings; als; als bei; alter; analysis; anderen; anomalies; anwendung; anwendung von; applikation; auch; auch als; auch bei; auch die; auch eine; auch für; auf; auf das; auf den; auf die; auf eine; auf teratogene; auffälligkeiten; aufgrund; aus; aus der; auswirkungen; auswirkungen auf; autoren; außerdem; b. bei; behandelt; behandelt werden; behandlung; behandlung mit; behandlung von; bei anderen; bei denen; bei der; bei einer; bei frauen; bei kindern; bei neugeborenen; bei nicht; bei schwangeren; bei über; beiden; beim; bekannt; beobachtet; berichtet; beschreibt; beschrieben; besonders; bestätigt; birth; bis; bis zu; bisher; bisher keine; bisher nicht; blut; bzw; cancer; case; chemotherapy; children; control; dabei; daher; das; das mit; das risiko; dass; dass die; dass eine; daten; davon; defects; dem; den fetus; denen; der; der behandlung; der fetalen; der geburt; der mutter; der mütterlichen; der schwangerschaft; der therapie; der wahl; des; development; diabetes; diagnostik; die; die als; die anwendung; die konzentration; die mit; die nicht; die von; die zur; diese; disease; diskutiert; dosen; dosis; drugs; durch; durch die; ebenfalls; effects; effekte; eigenschaften; ein kind; eine; eine andere; eine differenzierte; eine erhöhte; einer der; einer studie; einer therapie; eingenommen; eingesetzt; eingesetzt werden; einige; einnahme; empfehlung für; entwicklung; entwicklung der; erfahrungen; erfahrungen mit; erhöhtes; ersten; es bisher; es ist; es keine; es nach; es nicht; es sich; es wird; es wurde; es zu; etwa; exponierten; exposition; exposition mit; exposure; fall; fallberichte; fanden; fanden sich; fehlbildungen; fehlbildungen auf; fehlbildungsrisiko; fetal; fetalen; feten; fetus; frauen; frauen mit; fällen; führen; führt; für; für das; für den; für die; für eine; gabe; gabe von; gegenüber; gehören; gibt; gibt es; gilt; gruppe; gut; haben; hat; hat sich; hatte; heute; hinweise auf; human; häufiger; indikation; infant; insbesondere; insgesamt; insulin; intrauterine; invasive; ist; ist als; ist auch; ist bei; ist das; ist der; ist die; ist ein; ist für; ist mit; ist nicht; jahren; jedoch; jedoch nicht; kann; kann bei; kann die; kapitel; keine erfahrungen; keine fehlbildungen; keine für; keine hinweise; keinen; kind mit; kinder; kindern mit; kindern von; kombination mit; konnte; kontrollgruppe; konzentration; källén; können; liegen; liegen keine; malformations; man; maternal; mehr; menschen; mit; mit anderen; mit der; mit einer; mit g; mit oder; mittel; muss; muss eine; muss mit; mutter mit; mutter und; möglich; mütter; mütterlichen; nach; nach behandlung; nach der; nach einer; nebenwirkungen; neonatal; neugeborenen; nicht; nicht als; nicht auf; nicht beobachtet; nicht für; nicht mit; nicht nur; nicht vor; nicht zu; noch; noch bei; noch nicht; nur; nur bei; oder; oder zur; ohne; oral; pharmakologie und; plazenta; population; potenzial; praxis; pregnancy; pregnancy outcome; pregnancy pregnancy; prenatal; prospektiv; rate; rechtfertigt; report; retrospektiven; review; risiko; risiko für; risiko von; risikobegründeten; risikobewertung; risk; safety; schwangeren; schwangerschaft nicht; schwangerschaft wird; schwangerschaften; schwangerschaftsabbruch; schwangerschaftswoche; sehr; sein; seit; sich; sich bei; sich ein; sich mit; siehe; siehe auch; signifikant; sind; sind bei; sind keine; sind nicht; smoking; sollte; sollte die; sowie; sowie bei; sowohl; spontanabort; studie; studie mit; study; stunden; störungen; substanzen; symptome; syndrome; tag; tage; teratogene; teratogenität; therapie; therapie mit; therapie von; treatment; trimenon; trimenon keine; trimenon mit; trimester; täglich; und; und andere; und auf; und bei; und das; und der; und eine; und ist; und kann; und mit; und mitarbeiter; und nach; und toxikologie; und wird; und zu; unter; unter den; untersucht; untersuchungen; use; utero; vergleich; vitamin; vom; von; von anderen; von der; von einer; von g; vor; waren; weder; wegen; wegen der; weitere; wenn; wenn die; werden; werden die; werden kann; werden nach; werden und; wie; wie bei; wie eine; wie z.; wiesen; wird; wird auch; wird bei; wird der; wird ein; wird mit; wird von; wirkt; wirkung; woche; women; wurde; wurde eine; wurde mit; wurde nicht; wurde von; wurden bei; während; während der; z. b.; zeigten; zu den; zu einer; zum; zur; zur anwendung; zur therapie; zusammenhang mit; zwar; zwei; zwischen; über; über den; über die; über eine; übersicht; übersicht bei
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        item: #13 of 68
          id: cord-030992-ed0h045d
      author: Akhtar, Saeed
       title: Nutritional perspectives for the prevention and mitigation of COVID-19
        date: 2020-07-15
       words: 6854
      flesch: 27
     summary: 75, 76 Vitamin D Vitamin D receptors are present on monocytes, macrophages, T-and B-lymphocytes, and other immune cells. An ameliorative role of vitamin C supplementation in upper respiratory tract infections has been well described in numerous studies.
    keywords: cells; covid-19; function; immune; infections; iron; patients; role; selenium; supplementation; system; vitamin; zinc
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        item: #14 of 68
          id: cord-032544-2yrqjw1o
      author: Haroon, Sabrina-Wong-Peixin
       title: Treatment to reduce vascular calcification in hemodialysis patients using vitamin K (Trevasc-HDK): A study protocol for a randomized controlled trial
        date: 2020-09-04
       words: 5245
      flesch: 34
     summary: A link between end-stage renal disease and cardiovascular disease? Impact of high coronary artery calcification score (CACS) on survival in patients on chronic hemodialysis Vascular calcification: the killer of patients with chronic kidney disease Mechanistic insights into vascular calcification in chronic kidney disease Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia Vascular calcification in chronic kidney disease: an update The circulating calcification inhibitors, fetuin-A and osteoprotegerin, but not matrix Gla protein, are associated with vascular stiffness and calcification in children on dialysis Chronic kidney disease circulating calciprotein particles and extracellular vesicles promote vascular calcification: a role for GRP (Gla-Rich Protein) Vascular calcification: from pathophysiology to biomarkers Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency Kidney Diseases Improving Global Outcomes has recommended routine screening of vascular calcification for dialysis patients, but the subsequent plan of management remains unclear and controversial.
    keywords: aortic; cac; calcification; hemodialysis; patients; population; study; treatment; trial; vascular; vitamin
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        item: #15 of 68
          id: cord-034441-30pw419v
      author: Aslan, M. T.
       title: Is Vitamin D One of the Key Elements in COVID-19 Days?
        date: 2020-06-13
       words: 1500
      flesch: 42
     summary: update on the status The interplay between vitamin D and viral infections Association of vitamin D supplementation with respiratory tract infection in infants Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response Vitamin d-directed rheostatic regulation of monocyte antibacterial responses Vitamin D and respiratory infection in adults The role of cathelicidin and defensins in pulmonary inflammatory diseases Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37 Vitamin D Alleviates Rotavirus Infection through a Microrna-155-5p Mediated Regulation of the TBK1/ In Vivo and In Vitro Effect of high doses of vitamin D supplementation on dengue virus replication, Toll-like receptor expression, and cytokine profiles on dendritic cells Vitamin D and 1,25(OH)2D regulation of T cells Vitamin D alleviates lipopolysaccharideinduced acute lung injury via regulation of the reninangiotensin system Is vitamin D deficiency a major global health problem Aging decreases the capacity of human skin to produce Vitamin D3 The possible roles of solar ulraviolet-B radiation and vitamin D in reducing case fatality rates from the 1918-1919 influenza pandemic in the United States Does vitamin D status impact mortality from SARS-CoV-2 infection?
    keywords: covid-19; infection; rates; vitamin
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        item: #16 of 68
          id: cord-103451-h7986yl9
      author: Drodge, D. R.
       title: Causal analysis shows evidence of atopic dermatitis leading to an increase in vitamin D levels
        date: 2020-04-23
       words: 3438
      flesch: 43
     summary: We confirm that there is little evidence that vitamin D causally influences AD, as has previously been reported (Manousaki et al. 2017 ), but find evidence, from the reverse direction Mendelian Randomization analysis, that genetic risk of AD causally increases vitamin D levels. Whilst the AD-associated FLG gene has a particularly strong relationship with vitamin D, other AD SNPs show a consistent direction of effect, suggesting that AD more generally influences serum vitamin D levels.
    keywords: levels; license; preprint; vitamin
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        item: #17 of 68
          id: cord-254646-psolkrom
      author: Matsui, Mary S.
       title: Vitamin D Update
        date: 2020-10-14
       words: 5121
      flesch: 38
     summary: The Role of Vitamin D as a Possible Modulator of Susceptibility, Morbidity, and Mortality in SARS-CoV-2 (COVID- 19) That vitamin D should play a role in COVID-19 is not unexpected, since there has been believed to be a link between vitamin D deficiency and respiratory disease for over 100 years. World Health Organization Sunlight and dietary contributions to the seasonal vitamin D status of cohorts of healthy postmenopausal women living at northerly latitudes: a major cause for concern? Vitamin D microencapsulation and fortification: trends and technologies How to get vitamin D from sunlight Sunscreen photoprotection and vitamin D status An important discussion of study protocol variables and their influence on policy Sub-optimal application of a high SPF sunscreen prevents epidermal DNA damage in vivo Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn Kinetics of UV light-induced cyclobutane pyrimidine dimers in human skin in vivo: an immunohistochemical analysis of both epidermis and dermis Children sustain high levels of skin DNA photodamage, with a modest increase of serum 25-hydroxyvitamin D3, after a summer holiday in Northern Europe Global consensus recommendations on prevention and management of nutritional rickets Vitamin D and death by sunshine Protective effects of 1,25 dihydroxyvitamin D3 and its analogs on ultraviolet radiation-induced oxidative stress: a review Photoprotective properties of vitamin D and lumisterol hydroxyderivatives A systematic review of the influence of skin pigmentation on changes in the concentrations of vitamin D and 25-hydroxyvitamin D in plasma/serum following experimental UV irradiation Impact of solar ultraviolet B radiation (290-320 nm) on vitamin D synthesis in children with type IV and V skin Association of serum 25-hydroxyvitamin D with race/ethnicity and constitutive skin color in urban schoolchildren Melanin has a small inhibitory effect on cutaneous vitamin D synthesis: a comparison of extreme phenotypes Vitamin D(3) Supplementation reduces the symptoms of upper respiratory tract infection during winter training in vitamin D-insufficient taekwondo athletes: a randomized controlled trial Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS) Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths COVID-19 and vitamin D-is there a link and an opportunity for intervention? Letter: Covid-19, and vitamin D Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations
    keywords: 25(oh)d; deficiency; exposure; health; levels; serum; skin; status; study; sun; vitamin
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        item: #18 of 68
          id: cord-255233-rvgj6pvk
      author: Munday, Molly-Rose
       title: A Pilot Study Examining Vitamin C Levels in Periodontal Patients
        date: 2020-07-28
       words: 3897
      flesch: 48
     summary: Although a small study, this rate of vitamin C deficiency in the periodontal clinic is clinically important and correlations with disease severity and CRP suggests biological importance. Vitamin C deficiency is more common in smokers, the elderly and people of lower socio-economic status, potentially putting those groups at increased risk of periodontal diseases [24, 25] .
    keywords: crp; deficiency; disease; levels; patients; people; study; vitamin
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        item: #19 of 68
          id: cord-257595-l8bsoqbx
      author: Whittemore, Paul B.
       title: COVID-19 Fatalities, Latitude, Sunlight, and Vitamin D
        date: 2020-06-26
       words: 2439
      flesch: 40
     summary: Worldometer COVID-19 Coronavirus Pandemic The Role of Vitamin D in the Prevention of Infection and Mortality Vitamin D insufficiency is prevalent in severe COVID-19 The possible role of vitamin D in suppressing cytokine storm and associated mortality in COVID-19 patients Does vitamin D status impact mortality from SARS-CoV-2 infection? This study is the first to document a statistically significant correlation between a country's latitude and its COVID-19 mortality and is consistent with other research regarding latitude, Vitamin D deficiency, and COVID-19 fatalities.
    keywords: correlation; covid-19; latitude; sunlight; vitamin
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        item: #20 of 68
          id: cord-262773-mfta0emi
      author: Jolliffe, D.
       title: Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of aggregate data from randomised controlled trials
        date: 2020-07-17
       words: 5957
      flesch: 40
     summary: Vitamin D and SARS-CoV-2 virus/COVID-19 disease Modulation of the Immune Response to Respiratory Viruses by Vitamin D Vitamin D in the prevention of acute respiratory infection: systematic review of clinical studies Acute Respiratory Tract Infection and 25-Hydroxyvitamin D Concentration: A Systematic Review and Meta-Analysis A randomized controlled trial of vitamin D3 supplementation for the prevention of symptomatic upper respiratory tract infections Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren Effects of vitamin D supplementation to children diagnosed with pneumonia in Kabul: a randomised controlled trial Vitamin D supplementation for the prevention of acute respiratory tract infection: a randomized, double-blinded trial among young Finnish men Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection Effect of weekly vitamin D supplements on mortality, morbidity, and growth of low birthweight term infants in India up to age 6 months: randomised controlled trial High doses of vitamin D to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trial Effect on the incidence of pneumonia of vitamin D supplementation by quarterly bolus dose to infants in Kabul: a randomised controlled superiority trial Randomized trial of vitamin D supplementation and risk of acute respiratory infection in Mongolia Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: the VIDARIS randomized controlled trial Vitamin D3 supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study Vitamin D supplementation reduces the risk of acute otitis media in otitis-prone children Vitamin D3 Supplementation and Upper Respiratory Tract Infections in a Randomized, Controlled Trial Effect of vitamin D supplementation on antibiotic use: a randomized controlled trial Vitamin D3 and gargling for the prevention of upper respiratory tract infections: a randomized controlled trial Effects of vitamin D supplements on influenza A illness during the 2009 H1N1 pandemic: a randomized controlled trial Reduced primary care respiratory infection visits following pregnancy and infancy vitamin D supplementation: a randomised controlled trial Vitamin D3 supplementation in patients with chronic obstructive pulmonary disease (ViDiCO): a multicentre, double-blind, randomised controlled trial. The Lancet Respiratory medicine Double-blind randomised placebocontrolled trial of bolus-dose vitamin D3 supplementation in adults with asthma (ViDiAs) Double-blind randomised controlled trial of vitamin D3 supplementation for the prevention of acute respiratory infection in older adults and their carers (ViDiFlu) Weekly cholecalciferol supplementation results in significant reductions in infection risk among the vitamin D deficient: results from the CIPRIS pilot RCT Vitamin D supplementation and upper respiratory tract infections in adolescent swimmers: a randomized controlled trial Vitamin D Supplementation and the Risk of Colds in Patients with Asthma Improved Control of Childhood Asthma with Low-Dose, Short-Term Vitamin D Supplementation: A Randomized, Double-Blind, Placebo-Controlled Trial High-Dose Monthly Vitamin D for Prevention of Acute Respiratory Infection in Older Long-Term Care Residents: A Randomized Clinical Trial Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data Vitamin D Supplementation for Treatment and Prevention of Pneumonia in Under-five Children: A Randomized Double-blind Placebo Controlled Trial Effect of High-Dose vs Standard-Dose Wintertime Vitamin D Supplementation on Viral Upper Respiratory Tract Infections in Young Healthy Children Randomized Trial of Vitamin D Supplementation to Prevent Seasonal Influenza and Upper Respiratory Infection in Patients With Inflammatory Bowel Disease Effect of Vitamin D Supplementation on Recurrent Wheezing in Black Infants Who Were Born Preterm: The D-Wheeze Randomized Clinical Trial Randomized phase 2 trial of monthly vitamin D to prevent respiratory complications in children with sickle cell disease Effect of Vitamin D supplementation to reduce respiratory infections in children and adolescents in Vietnam: A randomized controlled trial.
    keywords: analysis; ari; effect; license; medrxiv; preprint; supplementation; trial; vitamin
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        item: #21 of 68
          id: cord-263749-bbhh5xb1
      author: Larenas-Linnemann, Désirée
       title: Enhancing innate immunity against virus in times of COVID-19: trying to untangle facts from fictions
        date: 2020-10-09
       words: 4134
      flesch: 0
     summary: Results For each of these interventions we briefly comment on their definition, possible mechanisms and evidence of clinical efficacy or lack of it, especially focusing on respiratory tract infections, viral infections and eventually a reduced mortality in severe respiratory infections in the intensive care unit. With the use of Pidotimod there is a lower recurrence of respiratory tract infections as compared to conventional treatment and less use of antibiotics We encourage to wait for the results of the ongoing RCT before using BCG vaccination for the prevention of COVID-19 Hetero- The immune stimulation produced by heterologous vaccines enhances the response to other pathogens, different from the one in the vaccine and was associated with reduced all-cause infant mortality (e.g. measles vaccine, BCG).
    keywords: activity; acute; analysis; cells; covid-19; exercise; immunity; infections; review; sleep; tract; vitamin
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        item: #22 of 68
          id: cord-265340-hc9003dj
      author: Merzon, Eugene
       title: Low plasma 25(OH) vitamin D level is associated with increased risk of COVID‐19 infection: an Israeli population‐based study
        date: 2020-07-23
       words: 3130
      flesch: 38
     summary: Notably, a recent study from the UK (31-33) that included 449 subjects (from the UK Biobank) with confirmed COVID-19 infection did not find an association between vitamin D metabolite concentration and the risk of viral infections (45) as well as COVID-19 infection (5, 7, (9) (10) (11) (12) (13) (14) (15) 19, (30) (31) (32) (33) (34) (35) (36) (37) (38) (39) (40) (41) (42) 46) . In particular, the pronounced impact of vitamin D metabolites on the immune system response, and on the development of COVID-19 infection by the novel SARS CoV-2 virus, has been described (5) (6) (7) (8) (9) (10) (11) (12) (13) (14) (15) .
    keywords: article; copyright; covid-19; infection; plasma; risk; study; vitamin
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        item: #23 of 68
          id: cord-269161-6nsvup68
      author: Kapoor, Indu
       title: Vitamins as adjunctive treatment for coronavirus disease!
        date: 2020-09-29
       words: 654
      flesch: 44
     summary: A controlled human trial has reported that Vitamin C significantly lowers the incidence of pneumonia, suggesting that vitamin C may affect susceptibility to lower respiratory tract infections Vitamins A, B6, B12, C, D and E work synergistically to support the protective activities of the immune cells.
    keywords: patients; vitamin
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        item: #24 of 68
          id: cord-271968-92p8dmha
      author: Polzonetti, Valeria
       title: Dietary Intake of Vitamin D from Dairy Products Reduces the Risk of Osteoporosis
        date: 2020-06-10
       words: 7015
      flesch: 34
     summary: Because of its widespread distribution, Vitamin D is not considered just a calcaemic hormone, and lack of vitamin D is actually associated with several other diseases [22] , such as psoriasis, multiple sclerosis, inflammatory bowel disease, diabetes (both type 1 and 2), hypertension, cardiovascular disease, metabolic syndromes, and different kinds of cancer [21] . Vitamin D, as calcitriol, influences calcium absorption in the intestine, and lack of vitamin D is associated with a reduced absorption of dietary calcium
    keywords: 25(oh)d; bone; calcium; cancer; food; fortification; intake; milk; osteoporosis; supplementation; vitamin
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        item: #25 of 68
          id: cord-276130-wjnwpn8f
      author: Bradley, Ryan
       title: The effects of Vitamin D on acute viral respiratory infections: a rapid review
        date: 2020-08-03
       words: 2123
      flesch: 34
     summary: daily dosing of vitamin D3 is preferred to 1 alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells Vitamin D: modulator of the immune system An update on vitamin D and human immunity Mechanisms underlying the effect of vitamin D on the immune system The vitamin D analog, TX527, promotes a human CD4+CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation Immunosuppressive actions of 1,25-dihydroxyvitamin D3: preferential inhibition of Th1 functions Vitamin D in autoimmune, infectious and allergic diseases: a vital player? Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells 25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells Vitamin D status has a linear association with seasonal infections and lung function in British adults Vitamin D status and acute respiratory infection: cross sectional results from the United States National Health and Nutrition Examination Survey Vitamin D in the prevention of acute respiratory infection: A systematic review of clinical studies Vitamin D and Susceptibility to Infection Vitamin D supplementation beyond the second year of life: Joint statement of the Nutrition Committee of the German Society for Pediatric and Adolescent Medicine (DGKJ) and the German Society for Pediatric Endocrinology and Diabetology (DGKED) Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data Vitamin D and lower respiratory tract infection in children: A systematic review and meta-analysis of randomized controlled trials Effect of Vitamin D3 Supplementation on Respiratory Tract Infections in Healthy Individuals: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Vitamin D supplementation for the prevention of childhood acute respiratory infections: a systematic review of randomised controlled trials. The available mechanistic evidence related to immunological requirements for adequate vitamin D, the availability of observational and experimental evidence suggestive of clinically meaningful benefits (especially in deficient/insufficient participants), and the high margin of safety, should make vitamin D a high priority for additional clinical research during the current COVID-19 pandemic.
    keywords: arti; children; reviews; studies; vitamin
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        item: #26 of 68
          id: cord-276483-4yp4beuh
      author: Cooper, Isabella D
       title: Relationships between hyperinsulinaemia, magnesium, vitamin D, thrombosis and COVID-19: rationale for clinical management
        date: 2020-09-16
       words: 7899
      flesch: 29
     summary: mmol/L is a proxy marker for insulin levels being inside of a range that is likely to be nonpathological for the patient 77 and indicates physiological insulin homeostasis range. A single fasting blood sample may miss its peak; when possible, gold standard practice would be to take three samples, 5 min apart or to consider a 2-hour postprandial level, especially if fasting insulin levels are <180 pmol/L. 85
    keywords: blood; carbohydrate; covid-19; diabetes; glucose; haem; health; hyperglycaemia; hyperinsulinaemia; insulin; levels; management; patients; production; restriction; risk; vitamin
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        item: #27 of 68
          id: cord-276942-dk1rk908
      author: Ebadi, Maryam
       title: Perspective: improving vitamin D status in the management of COVID-19
        date: 2020-05-12
       words: 2232
      flesch: 24
     summary: SARS-CoV-2 Cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies Di Napoli R. Features, evaluation and treatment coronavirus (COVID-19) Vitamin D and respiratory health Severe vitamin D deficiency is a prognostic biomarker in autoimmune hepatitis Evolving role of vitamin D in immune-mediated disease and its implications in autoimmune hepatitis Vitamin D deficiency in patients with common variable immunodeficiency, with autoimmune diseases and bronchiectasis The role of vitamin D in the aging adult Vitamin D and calcium deficits predispose for multiple chronic diseases The vitamin D dose response in obesity Smoking is a significant determinant of low serum vitamin D in young and middle-aged healthy males COVID-19 and African Americans Vitamin D status of black and white Americans and changes in vitamin D metabolites after varied doses of vitamin D supplementation Sunlight and vitamin D: a global perspective for health Temperature, humidity and latitude analysis to predict potential spread and seasonality for Epidemic influenza and vitamin D Vitamin D effects on lung immunity and respiratory diseases Perspective: improving vitamin D status in the management of COVID-19 Vitamin D alleviates lipopolysaccharideinduced acute lung injury via regulation of the reninangiotensin system Vitamin D and lung disease Modulation of the immune response to respiratory viruses by vitamin D Angiotensin converting enzyme 2 as the molecular bridge between epidemiologic and clinical features of COVID-19 25-dihydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxy vitamin D3: production and biological activity studies in pulmonary alveolar type II cells Regulation of human pulmonary surfactant protein gene expression by 1alpha,25-dihydroxyvitamin D3 High dose vitamin D administration in ventilated intensive care unit patients: a pilot double blind randomized controlled Trial High-dose vitamin D3 administration is associated with increases in hemoglobin concentrations in mechanically ventilated critically Ill adults: a pilot double-blind, randomized, placebo-controlled trial Serum 25-hydroxyvitamin D and the incidence of acute viral respiratory tract infections in healthy adults The importance of body weight for the dose response relationship of oral vitamin D supplementation and serum 25-hydroxyvitamin D in healthy volunteers Influence of a single oral dose of vitamin D (2) on serum 25-hydroxyvitamin D concentrations in tuberculosis patients Evaluation of vitamin D3 intakes up to 15,000 international units/day and serum 25-hydroxyvitamin D concentrations up to 300 nmol/L on calcium metabolism in a community setting Vitamin D deficiency as a potential marker of benign prostatic hyperplasia High prevalence of vitamin D deficiency among iranian population: a systematic review and meta-analysis 25(OH) vitamin D and functional outcomes in older adults admitted to rehabilitation units: the safari study Vitamin D deficiency and insufficiency among US adults: prevalence, predictors and clinical implications Prevalence and risk factors of vitamin D deficiency in healthy adults aged 18-65 years in northern France Prevalence, determinants and clinical correlates of vitamin D deficiency in patients with chronic obstructive pulmonary disease in London Vitamin D deficiency is also common in obesity [10] and smokers
    keywords: covid-19; deficiency; levels; patients; vitamin
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        item: #28 of 68
          id: cord-284193-qslc2wry
      author: Malek Mahdavi, Aida
       title: A brief review of interplay between vitamin D and angiotensin‐converting enzyme 2: Implications for a potential treatment for COVID‐19
        date: 2020-06-25
       words: 3235
      flesch: 33
     summary: https://orcid.org/0000-0003-0176-5438 A pneumonia outbreak associated with a new coronavirus of probable bat origin Clinical features of patients infected with 2019 novel coronavirus in Wuhan Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Vitamin D insufficiency among free-living healthy young adults Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease Vitamin D: nutrient, hormone, and immunomodulator Impact of vitamin D on immune function: lessons learned from genome-wide analysis Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission Coronaviruses: an overview of their replication and pathogenesis Receptor recognition and cross-species infections of SARS coronavirus A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus Structure analysis of the receptor binding of 2019-nCoV Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Molecular mechanism of vitamin D in the cardiovascular system Bats and coronaviruses Coronavirus envelope protein: current knowledge SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor Molecular immune pathogenesis and diagnosis of COVID-19 The trinity of COVID-19: immunity, inflammation and intervention A novel angiotensin converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa ACE2 of the heart: from angiotensin I to angiotensin (1-7) ACE and ACE2 in kidney disease Is there an association between COVID-19 mortality and the renin-angiotensin system -a call for epidemiologic investigations New perspectives in the reninangiotensinaldosterone system (RAAS) IV: circulating ACE2 as a biomarker of systolic dysfunction in human hypertension and heart failure Circulating ACE2 activity is increased in patients with type 1 diabetes and vascular complications Influence of drugs on vitamin D and calcium metabolism 1,25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter Effect of Vitamin D on ACE2 and Vitamin D Receptor Expression in Rats with LPS-Induced Acute Lung Injury Calcitriol regulates angiotensin-converting enzyme and angiotensin converting-enzyme 2 in diabetic kidney disease Paricalcitol modulates ACE2 shedding and renal ADAM17 in NOD mice beyond proteinuria Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: role of reninangiotensin system Effect of vitamin D supplementation on non-skeletal disorders: a systematic review of meta-analyses and randomised trials Non-skeletal health effects of vitamin D supplementation: a systematic review on findings from meta-analyses summarizing trial data Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data Letter: COVID-19, and vitamin D Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees north supports vitamin D as a factor determining severity Does vitamin D status impact mortality from SARS-CoV-2 infection How to cite this article:
    keywords: ace2; acute; angiotensin; cells; covid-19; enzyme; lung; sars; vitamin
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        item: #29 of 68
          id: cord-284760-i1lspg8i
      author: Bashandy, Samir A. E.
       title: Potential effects of the combination of nicotinamide, vitamin B2 and vitamin C on oxidative-mediated hepatotoxicity induced by thioacetamide
        date: 2018-02-14
       words: 4439
      flesch: 31
     summary: Liver disease in Egypt: hepatitis C superseded schistosomiasis as a result of iatrogenic and biological factors Bioactive food as dietary interventions for liver and gastrointestinal disease Rat HMG-CoA reductase activation in thioacetamide-induced liver injury is related to an increased reactive oxygen species content A review of nicotinamide: treatment of skin diseases and potential side effects Pellagra: dermatitis, dementia, and diarrhea Effect of combined Fenofibrate and nicotinamide on oxidative stress and inflammatory cytokines involved in cisplatininduced nephrotoxicity in rats Antinociceptive and antiinflammatory activities of nicotinamide and its isomers in different experimental models Nicotinamide prevents interleukin-1 effects on accumulated insulin release and nitric oxide production in rat islets of Langerhans Oxygen radicals generated by the enzyme xanthine oxidase lyse rat pancreatic islet cells in vitro Nicotinamide and 3-aminobenzamide reduce interferon-gamma-induced class II MHC (HLA-DR and -DP) molecule expression on cultured humanendothelial cells and fibroblasts Inhibitory effects of nicotinamide on intercellular adhesion molecule-1 expression on cultured human thyroid cells Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells Evaluation of the effects of nicotinamide on the bleomycin-induced pulmonary fibrosis in rat Doxorubicin induced nephrotoxicity: protective effect of nicotinamide Modern nutrition in health and disease Effectiveness of riboflavin in pediatric migraine prevention Riboflavin (vitamin B-2) reduces hepatocellular injury following liver ischaemia and reperfusion in mice Riboflavin (vitamin B2) and oxidative stress: a review Ameliorative effect of riboflavin on the cisplatin induced nephrotoxicity and hepatotoxicity under photoillumination Influence of vitamin C supplementation on oxidative stress and neutrophil inflammatory response in acute and regular exercise Vitamin C as an antioxidant: evaluation of its role in disease prevention Combined protective effect of vitamins C and E on cadmium induced oxidative liver injury in rats The Hepatoprotective effect of vitamin C and E on hepatotoxicity induced by ethanol in Sprague Dawley rats Combined effects of vitamin C, vitamin E, and sodium Selenate supplementation on absolute ethanolinduced injury in various organs of rats The preventive and therapeutic role of curcumin in liver cirrhosis Nicotinamide supplementation protects gestational diabetic rats by reducing oxidative stress and enhancing immune responses Riboflavin attenuates lipopolysaccharide-induced lung injury in rats Oral administration of vitamin C and histidine attenuate cyclophosphamide-induced hemorrhagic cystitis in rats Single dose intravenous thioacetamide administration as a model of acute liver damage in rats The undenatured whey protein enhanced wound healing in mice Whey protein enhances normal inflammatory responses during cutaneous wound healing in diabetic rats Zinc improves the immune function and the proliferation of lymphocytes in Cadmium-treated rats Antioxidant Potential of Spirulina platensis Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats Wound healing of different molecular weight of hyaluronan; in-vivo study Impairment of active avoidance learning and sensory motor reflexes in mice offspring induced by perinatal acute toxic exposure to selenium Pathophysiological basis for antioxidant therapy in chronic liver disease Hepatoprotective Effects of vitamin C and micronized vitamin C against paracetamol induced hepatotoxicity in rats: a comparative study Nicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsia Role of nicotinamide (vitamin B3) in acetaminophen-induced changes in rat liver: Nicotinamide effect in acetaminophen-damged Protective effects of ascorbic acid, dl-alpha-tocopherol acetate, and sodium Selenate on ethanol-induced liver damage of rats Role of zinc as an antioxidant and anti-inflammatory to relieve cadmium oxidative stress induced testicular damage in rats Carbon tetrachloride-induced hepatotoxicity and nephrotoxicity in rats: protective role of vitamin C Vitamin C supplementation reconstitutes polyfunctional T cells in streptozotocin-induced diabetic rats Determination of ascorbic acid and dehydroascorbic acid in biological samples by high-performance liquid chromatography using subtraction methods: reliable reduction with tris[2-carboxyethyl]phosphine hydrochloride Antioxidants: characterization, natural sources, extraction and analysis Scleral cross-linking using riboflavin UVA irradiation for the prevention of myopia progression in a Guinea pig model: blocked axial extension and altered scleral microstructure Inactivation of Middle East respiratory syndrome coronavirus (MERS-CoV) in plasma products using a riboflavinbased and ultraviolet light-based photochemical treatment Vitamin B2: a promising adjuvant in cisplatin based chemoradiotherapy by cellular redox management Riboflavin ameliorates cisplatin induced toxicities under Photoillumination Folic acid and melatonin ameliorate carbon tetrachloride-induced hepatic injury, oxidative stress and inflammation in rats Study of the effects of melatonin on experimentally induced hepatic Fibrogenesis in rats Reproducible production of thioacetamideinduced macronodular cirrhosis in the rat with nomortality Hepatocytes are protected by herb Phyllanthus Niruri protein isolate against thioacetamide toxicity Melatonin ameliorates carbon tetrachlorideinduced hepatic fibrogenesis in rats via inhibition of oxidative stress Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes Regulatory role of vitamins E and C on extracellular matrix components of the vascular system Vitamin C Inhibits lipid oxidation in human HDL Relationship of nicotinamide and nicotinic acid to hypolipidemia Widespread effects of nicotinic acid on gene expression in insulin-sensitive tissues: implications for unwanted effects of nicotinic acid treatment Tumor necrosis factor-alpha modulates human in vivo lipolysis Histopathological examination of hepatic sections from TAA rats revealed the presence of vacuolated hepatocytes with degenerated nuclei and irregular and damaged cell membranes.
    keywords: antioxidant; group; hepatic; liver; nicotinamide; rats; stress; study; taa; vitamin
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        item: #30 of 68
          id: cord-285641-y5ianyqi
      author: Bamji, Mahtab S.
       title: Nutritionally sensitive agriculture—an approach to reducing hidden hunger
        date: 2020-10-01
       words: 5616
      flesch: 47
     summary: Rome: FAO and CAB International Nutrition sensitive agriculture to achieve better nutritional outcomes Food based approach to combat micronutrient deficiencies Dynamics of food consumption and nutrient security in, India Home gardening for combating vitamin A deficiency in rural India Food-based strategies to control vitamin A deficiency Impact of homestead gardening program on household food security and empowerment of women in Bangladesh Improving diet quality and micronutrient nutrition Food security through homestead vegetable production in the smallholder agricultural improvement project (SAIP) area Homestead food production model contributes to improved household food security and nutrition status of young children and women in poor populations A farming system model to leverage agriculture for nutritional outcomes Operationalising the concept of farming system for nutrition, through the promotion of nutrition-sensitive agriculture Establishing agriculture-nutrition programme to diversify household food and diets in rural India Improving household diet diversity through promotion of nutrition gardens in India Recent evaluation of the impact of this strategy on household food consumption showed remarkable increase in the monthly consumption of fruits and vegetables-frequency as well as quantity, as seen from a baseline survey in 2014 and end-line survey in 2017 of a sample of 190 households in each location [23] .
    keywords: agriculture; consumption; families; food; gardens; health; households; increase; india; nutrition; poultry; vegetables; vitamin
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        item: #31 of 68
          id: cord-286923-o4fj8kx0
      author: Berhan, Yifru
       title: What immunological and hormonal protective factors lower the risk of COVID-19 related deaths in pregnant women?
        date: 2020-07-18
       words: 4552
      flesch: 25
     summary: Emphatic E3 increases the production of anti-inflammatory cytokines (IL-10 and IL-5) and reduces the production of proinflammatory cytokines (like TNF-α) The immune modulating and anti-inflammatory actions of estradiol (E2) and estriol (E3) is also well noted during pregnancy.
    keywords: cells; covid-19; cytokines; disease; immune; inflammatory; pregnancy; risk; vitamin; women
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        item: #32 of 68
          id: cord-286960-uz34fjyp
      author: Ali, Nurshad
       title: Role of vitamin D in preventing of COVID-19 infection, progression and severity
        date: 2020-06-20
       words: 4037
      flesch: 35
     summary: Vitamin D insufficiency affects the immune functions as vitamin D exerts an immunomodulation role [5] , increasing innate immunity by secretion of antiviral peptides [6, 7] , which improves mucosal defenses. The vitamin D deficiency pandemic: approaches for diagnosis, treatment and prevention Vitamin D in autoimmunity: molecular mechanisms and therapeutic potential Influence of vitamin d on islet autoimmunity and beta-cell function in type 1 diabetes Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions Modulation of the immune response to respiratory viruses by vitamin D Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1, 25-dihydroxyvitamin D3 Direct and indirect induction by 1, 25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin β2 innate immune pathway defective in Crohn disease Epidemic influenza and vitamin D Cod liver oil, vitamin A toxicity, frequent respiratory infections, and the vitamin D deficiency epidemic Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey The association between vitamin D deficiency and community-acquired pneumonia:
    keywords: covid-19; infections; levels; risk; study; supplementation; vitamin
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        item: #33 of 68
          id: cord-290428-zrlqzbss
      author: de Faria Coelho-Ravagnani, Christianne
       title: Dietary recommendations during the COVID-19 pandemic
        date: 2020-07-12
       words: 6421
      flesch: 39
     summary: Furthermore, water intake comes mostly from beverages (about 75%) and food intake (about 25%), especially from fresh food such as fruits and vegetables. Consume other foods of animal origin in moderation; Consume nuts, seeds, and olive oil; Avoid processed foods and fast food NA NA ASBRAN (2020) 13
    keywords: covid-19; diet; disease; food; fruits; guidelines; health; immune; nutrition; pandemic; risk; vegetables; vitamin; water; zinc
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        item: #34 of 68
          id: cord-290592-c9bsielo
      author: Wang, Rui
       title: The vitamin D for COVID-19 (VIVID) trial: A pragmatic cluster-randomized design
        date: 2020-10-10
       words: 4956
      flesch: 38
     summary: An association of serum vitamin D concentrations < 40 nmol/L with acute respiratory tract infection in young Finnish men Vitamin D status and acute lower respiratory J o u r n a l P r e -p r o o f infection in early childhood in Sylhet Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and metaanalysis of individual participant data Randomized trial of vitamin D supplementation and risk of acute respiratory infection in Mongolia Vitamin D3 supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study Vitamin D3 and gargling for the prevention of upper respiratory tract infections: a randomized controlled trial Effect of monthly high-dose vitamin D supplementation on acute respiratory infections in older adults: A randomized controlled trial Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: the VIDARIS randomized controlled trial Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study COVID-19 infection: the perspectives on immune responses Vitamin D status of HIV-infected women and its association with HIV disease progression, anemia, and mortality Vitamin D and the immune system Vitamin D and Inflammation: Potential Implications for Severity of Covid-19 Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the Vitamin D supplementation could possibly improve clinical outcomes of patients infected with coronavirus-2019 (COVID-19) SSRN Patterns of COVID-19 mortality and vitamin D: An Indonesian Study Longitudinal data analysis for discrete and continuous outcomes Household secondary attack rate of COVID-19 and associated determinants in Guangzhou, China: a retrospective cohort study Secondary Attack Rate of COVID-19 in household contacts: Systematic review Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs Designing Clinical Trials That Accept New Arms: An Example in Metastatic Breast Cancer Effects of vitamin D supplementation on strength, physical performance, and falls in older persons: a systematic review The tolerability and biochemical effects of high-dose bolus vitamin D2 and D3 supplementation in patients with vitamin D insufficiency Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: Ecologic and demographic data also provide support for a protective role of vitamin D studies [28, 29] .
    keywords: covid-19; household; infection; respiratory; study; supplementation; treatment; vitamin
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        item: #35 of 68
          id: cord-291340-8gj0ofmp
      author: Misra, Anoop
       title: Balanced Nutrition is Needed in Times of COVID19 Epidemic in India: A Call for Action for all Nutritionists and Physicians
        date: 2020-08-27
       words: 2151
      flesch: 33
     summary: In such patients mega doses are required in grams [23] . In this context proteins, vitamins, minerals, trace elements, prebiotics, probiotics, omega-3 polyunsaturated fatty acids and specific diets have been researched, but direct research on COVID19 patients are lacking.
    keywords: covid-19; covid19; diabetes; infections; mortality; nutrients; patients; vitamin
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        item: #36 of 68
          id: cord-294800-akr4f5p8
      author: Kabir, Md. Tanvir
       title: nCOVID-19 Pandemic: From Molecular Pathogenesis to Potential Investigational Therapeutics
        date: 2020-07-10
       words: 14110
      flesch: 33
     summary: Recently, it has been observed that nCOVID-19 might predispose to both arterial and venous thromboembolic disease because of immobilization, hypoxia, inflammation, and diffuse intravascular coagulation Guan et al., 2020; Klok et al., 2020; Wang et al., 2020a; Zhou et al., 2020) . Also, the derivatives of teicoplanin including telavancin, dalbavancin, and oritavancin, were also found to block the entry of SARS, MERS, and Ebola viruses (Zhou et al., 2016) .
    keywords: acute; antiviral; cells; coronavirus; cov-2; day; disease; drug; et al; host; human; individuals; infection; influenza; mers; ncovid-19; novel; patients; pneumonia; protein; response; sars; studies; study; syndrome; transmission; treatment; use; vitamin
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        item: #37 of 68
          id: cord-295414-v10454ns
      author: Baktash, Vadir
       title: Vitamin D status and outcomes for hospitalised older patients with COVID-19
        date: 2020-08-26
       words: 3787
      flesch: 40
     summary: These patients were investigated with real-time reverse transcriptase-PCR (RT-PCR) assay for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) on nasopharyngeal swab, blood tests including vitamin D levels (25-hydroxyvitamin D (25(OH)D), basic observations, and chest X-ray (CXR) and/or chest CT. All patients had vitamin D levels checked in keeping with good medical practice.
    keywords: covid-19; deficiency; infection; outcomes; patients; serum; study; vitamin
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        item: #38 of 68
          id: cord-296836-aizquh16
      author: Brenner, Hermann
       title: Vitamin D Insufficiency and Deficiency and Mortality from Respiratory Diseases in a Cohort of Older Adults: Potential for Limiting the Death Toll during and beyond the COVID-19 Pandemic?
        date: 2020-08-18
       words: 4449
      flesch: 34
     summary: It has been suggested that vitamin D(3) supplementation might help to reduce respiratory disease mortality. Overall, 41% (95% confidence interval: 20–58%) of respiratory disease mortality was statistically attributable to vitamin D insufficiency or deficiency.
    keywords: 25(oh)d; covid-19; deficiency; disease; insufficiency; levels; mortality; vitamin
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        item: #39 of 68
          id: cord-298542-4du3gar7
      author: Karcioglu Batur, Lutfiye
       title: The role of DBP gene polymorphisms in the prevalence of new coronavirus disease 2019 infection and mortality rate
        date: 2020-08-16
       words: 1626
      flesch: 26
     summary: Coronavirus disease (COVID-19) Situation Report-164 The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality Vitamin D binding protein, total and free vitamin D levels in different physiological and pathophysiological conditions Vitamin D binding protein polymorphisms influence susceptibility to hepatitis C virus infection in a high-risk Chinese population Associations of vitamin D binding protein variants with the vitamin D-induced increase in serum 25-hydroxyvitamin D Vitamin D-binding protein and its polymorphisms as a predictor for metabolic syndrome GC Glu416Asp and Thr420Lys polymorphisms contribute to gastrointestinal cancer susceptibility in a Chinese population Systematic review and meta-analysis to establish the association of common genetic variations in vitamin D binding protein with chronic obstructive pulmonary disease Distribution of variants in multiple vitamin D-related loci Association between vitamin D deficiency and common variants of Vitamin D binding protein gene among Mexican Mestizo and indigenous postmenopausal women The associations of 25-hydroxyvitamin D levels, vitamin D binding protein gene polymorphisms, and race with risk of incident fracture-related hospitalization: twenty-year follow-up in a bi-ethnic cohort (the ARIC Study) Genetic variation of the vitamin D binding protein affects vitamin D status and response to supplementation in infants The rs1803274 polymorphism of the BCHE gene is associated with an increased risk of coronary instent restenosis Posttraumatic stress disorder is associated with reduced vitamin D levels and functional polymorphisms of the vitamin D binding-protein in a population-based sample The Relationship Between the Genotype of Vitamin D Binding Protein and Plasma 25 OH D Concentration in Turkish Population Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients Polymorphisms in the GC gene for vitamin D binding protein and their association with vitamin D and bone mass in young adults Vitamin D pathway gene polymorphisms influenced vitamin D level among pregnant women Hypovitaminosis D in developing countries-prevalence, risk factors and outcomes Scientific Strabismus or two related pandemics: coronavirus disease and vitamin D deficiency Prevalence of vitamin D deficiency in otherwise healthy individuals between the ages of 18 and 90 years in southeast Turkey Adjustments in analyses of vitamin D status, allowing for vitamin D determinants, for Covid-19 risks Vitamin D and the anti-viral state Vitamin D and innate immunity Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: role of renin-angiotensin system ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome The vitamin D axis in the lung: a key role for vitamin D-binding protein Vitamin D-binding protein contributes to COPD by activation of alveolar macrophages Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene Vitamin D deficiency Update in vitamin D Vitamin D-binding protein and vitamin D status of black Americans and white Americans Impaired bone marrow-derived macrophage differentiation in vitamin D deficiency 25-Dihydroxyvitamin D3 is a potent suppressor of interferon gamma-mediated macrophage activation SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes GT genotype was found to confer this susceptibility to the popula- Vitamin D plays a major role in regulating the immune system, including immune responses to viral infection.
    keywords: mortality; prevalence; rates; vitamin
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        item: #40 of 68
          id: cord-300192-fgueg4mo
      author: Richardson, David P.
       title: Nutritional status of micronutrients as a possible and modifiable risk factor for COVID-19: a UK perspective
        date: 2020-08-20
       words: 5750
      flesch: 26
     summary: The vitamin D deficiency pandemic: approaches for diagnosis, treatment and prevention Vitamin D deficiency: defining, prevalence, causes and strategies of addressing Contribution of nutrition science to the vitamin D field -clarity or confusion? Vitamin D deficiency 2.0: an update on the current status worldwide SACN vitamin D and health report Vitamin D levels and deficiency with different occupations: a systematic review Review: non-musculoskeletal benefits of vitamin D Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity Evaluation of vitamin D 3 intakes up to 15,000 international units/day and serum 25-hydroxyvitamin D concentrations up to 300 nmol/L on calcium metabolism in a community setting Controversies in vitamin D: summary statement from an international conference Dietary supplement use at the population level: recent experience from the 1994-5 British National Diet and Nutrition Survey: people aged 65 and over Hospital mealtimes: action research for change? Incidence and recognition of malnutrition in hospital Nutritional issues in nursing home care Protein energy undernutrition in hospital patients Trace mineral intake and deficiencies in older adults living in the community and institutions: a systematic review Age-related smell and taste impairment and vitamin D associations in the U.S. Adults National Health and Nutrition Examination Survey Vitamin D in renal transplantation -from biological mechanism to clinical benefits Current evidence on vitamin D deficiency and kidney transplant: what's new? Food and Nutrition Board & Institute of Medicine (1997) It has also been shown that there is a linear association between vitamin D status and respiratory infections and lung function (33) .
    keywords: covid-19; deficiency; health; infections; intakes; nutrition; risk; status; system; vitamin
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        item: #41 of 68
          id: cord-303917-2tu707ng
      author: Zhang, Lei
       title: Potential interventions for novel coronavirus in China: A systematic review
        date: 2020-03-03
       words: 5438
      flesch: 36
     summary: The effect of ascorbic acid on infection chick-embryo ciliated tracheal organ cultures by coronavirus Nutrients and their role in host resistance to infection Vitamin C intake and susceptibility to pneumonia Vitamin D insufficiency among free-living healthy young adults Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease Acute phase response elicited by experimental bovine diarrhea virus (BVDV) infection is associated with decreased vitamin D and E status of vitamin-replete preruminant calves Vitamin E metabolic effects and genetic variants: a challenge for precision nutrition in obesity and associated disturbances Vitamin E deficiency intensifies the myocardial injury of coxsackievirus B3 infection of mice Increased virulence of coxsackievirus B3 in mice due to vitamin E or selenium deficiency Macrophage-derived extracellular vesicles induce long-lasting immunity against hepatitis C virus which is blunted by polyunsaturated fatty acids Plasma fatty acid levels in patients with acquired immune deficiency syndrome and in controls The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza Anti-HCV activities of selective polyunsaturated fatty acids Selenium and human health Micronutrients and host resistance to viral infection Review: micronutrient selenium deficiency influences evolution of some viral infectious diseases Selenium deficiency increases the pathology of an influenza virus infection Rapid genomic evolution of a non-virulent coxsackievirus B3 in selenium-deficient mice results in selection of identical virulent isolates Combined adjuvant effect of ginseng stem-leaf saponins and selenium on immune responses to a live bivalent vaccine of Newcastle disease virus and infectious bronchitis virus in chickens Zinc and immunity: an essential interrelation Zinc deficiency Zinc supplementation for the treatment of measles in children Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture Crossing the iron gate: why and how transferrin receptors mediate viral entry Childhood iron deficiency anemia leads to recurrent respiratory tract infections and gastroenteritis Chicken interferon type I inhibits infectious bronchitis virus replication and associated respiratory illness Prevention of experimental coronavirus colds with intranasal alpha-2b interferon Ribavirin and interferon-beta synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds Interferon priming enables cells to partially overturn the SARS coronavirus-induced block in innate immune activation Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques Proposal for vaccination against SARS coronavirus using avian infectious bronchitis virus strain H from The Netherlands Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study Current treatment options and the role of peptides as potential therapeutic components for Middle East Respiratory Syndrome (MERS): a review Uses of intravenous gammaglobulin in immune hematologic disease Acute respiratory distress syndrome in critically ill patients with severe acute respiratory syndrome Strokes, thromboembolic events, and IVIg: rare incidents blemish an excellent safety record Thymosin alpha 1 and HIV-1: recent advances and future perspectives A reappraisal of thymosin alpha1 in cancer therapy Serum thymosin alpha 1 levels in normal and pathological conditions Thymosin alpha 1 antagonizes dexamethasone and CD3-induced apoptosis of CD4+ CD8+ thymocytes through the activation of cAMP and protein kinase C dependent second messenger pathways Clinical investigation of outbreak of nosocomial severe acute respiratory syndrome Anti-SARS coronavirus agents: a patent review (2008-present) Modulation of immune response in aged humans through different administration modes of thymopentin Phase variation in the modulation of the human immune response Thymopentin as adjuvant in non-responders or hyporesponders to hepatitis B vaccination The general immunopharmacology of levamisole Lymphocyte subsets in measles. Depressed helper/inducer subpopulation reversed by in vitro treatment with levamisole and ascorbic acid Systemic cyclosporine and corneal transplantation Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A Factor in virus replication and potential target for anti-viral therapy The SARS-coronavirus-host interactome: identification of cyclophilins as target for pancoronavirus inhibitors Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus Diarylheptanoids from Alnus japonica inhibit papain-like protease of severe acute respiratory syndrome coronavirus Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro Flavonoids: an overview Flavonoids from pterogyne nitens inhibit hepatitis C virus entry Inhibition of SARS-CoV 3CL protease by flavonoids Characteristics of flavonoids as potent MERS-CoV 3C-like protease inhibitors Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition Angiotensin-converting enzyme-2: a molecular and cellular perspective Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus The secret life of ACE2 as a receptor for the SARS virus Characterization of severe acute respiratory syndromeassociated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry Severe acute respiratory syndrome coronavirus entry into host cells: Opportunities for therapeutic intervention Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association Effects of chloroquine on viral infections: an old drug against today's diseases? Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Membrane-related effects underlying the biological activity of the anthraquinones emodin and barbaloin Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction Old drugs as lead compounds for a new disease?
    keywords: acute; addition; coronavirus; cov; covid-19; human; immune; infection; patients; replication; sars; syndrome; treatment; vitamin
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        item: #42 of 68
          id: cord-310738-fnsf2qqm
      author: Yalcin Bahat, Pinar
       title: Micronutrients in COVID-19 Positive Pregnancies
        date: 2020-09-23
       words: 2607
      flesch: 48
     summary: Access Immunoassay System (© 2020Beckman Coulter Inc., Brea, CA, USA) was used to quantitate serum vitamin B12 levels. Tubes were submitted to the hospital's central laboratory for determination of 25(OH)D, zinc, and vitamin B12 levels.
    keywords: 25(oh)d; covid-19; levels; serum; study; vitamin; zinc
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        item: #43 of 68
          id: cord-311965-3x3tjzhi
      author: Alexander, Jan
       title: Early Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19
        date: 2020-08-07
       words: 5169
      flesch: 31
     summary: The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality Editorial: Low population mortality from COVID-19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity Prior diagnoses and medications as risk factors for COVID-19 in a Los Angeles Health System Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalised with COVID-19 are associated with greater disease severity Factors Associated with Hospitalization and Disease Severity in a Racially and Ethnically Diverse Population of COVID-19 Patients Vitamin D and respiratory health Vitamin D deficiency as a risk factor for infection, sepsis and mortality in the critically ill: Systematic review and meta-analysis Link between community-acquired pneumonia and vitamin D levels in older patients Addition of vitamin D status to prognostic scores improves the prediction of outcome in community-acquired pneumonia Vitamin D Status and Long-Term Mortality in Community-Acquired Pneumonia: Secondary Data Analysis from a Prospective Cohort Association between prehospital vitamin D status and incident acute respiratory failure in critically ill patients: A retrospective cohort study Vitamin D increases the antiviral activity of bronchial epithelial cells in vitro Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37 Effects of vitamin D on airway epithelial cell morphology and rhinovirus replication Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state Relationship to Duration of Infection Vitamin D inhibition of pro-fibrotic effects of transforming growth factor beta1 in lung fibroblasts and epithelial cells The role of vitamin D supplementation in the risk of developing pneumonia: Epidemiological studies suggested an inverse association between circulating levels of 25(OH)-D3, a biomarker of vitamin D status, and inflammatory biomarkers, including CRP and IL-6
    keywords: covid-19; deficiency; infections; patients; sars; selenium; status; supplementation; treatment; vitamin; zinc
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        item: #44 of 68
          id: cord-317265-n6x0r58i
      author: Singh, Varsha
       title: Can Vitamins, as Epigenetic Modifiers, Enhance Immunity in COVID-19 Patients with Non-communicable Disease?
        date: 2020-07-13
       words: 3942
      flesch: 26
     summary: The purpose of this review is to provide evidence to consider vitamins as epigenetic modifiers to enhance immunity and reduce inflammatory response in COVID-19 patients with non-communicable diseases. It is noteworthy that this individualized approach has a potential of obtaining positive results for COVID-19 patients, if individuals are thoroughly tested and treated according to their unique metabolic function.
    keywords: cancer; covid-19; disease; factors; ncds; non; patients; response; risk; system; vitamin
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        item: #45 of 68
          id: cord-317758-oym8s4af
      author: Manson, JoAnn E.
       title: Commentary. Eliminating Vitamin D Deficiency During the COVID-19 Pandemic: A Call to Action
        date: 2020-07-23
       words: 1301
      flesch: 41
     summary: The National Academies Press Vitamin D status in the United States Vitamin D and the immune system Vitamin D and inflammation: potential implications for severity of Covid-19 Letter: does vitamin D have a potential role against COVID-19? If vitamin D is beneficial in this regard-and accumulating evidence suggests that it may be-then the high prevalence of vitamin D deficiency in the United States and globally, especially among nonwhite racial/ethnic groups, is cause for heightened concern and should be rectified expeditiously.
    keywords: covid-19; vitamin
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        item: #46 of 68
          id: cord-320959-sgdqhtns
      author: Lee, Hanjun
       title: Vitamin E Acetate as Linactant in the Pathophysiology of EVALI
        date: 2020-08-12
       words: 6726
      flesch: 25
     summary: Update: Characteristics of a Nationwide Outbreak of E-cigarette, or Vaping, Product Use-Associated Lung Injury -United States Pulmonary Illness Related to E-Cigarette Use in Illinois and Wisconsin -Final Report Update: Interim Guidance for Health Care Providers Evaluating and Caring for Patients with Suspected E-cigarette, or Vaping, Product Use Associated Lung Injury -United States Imaging of vaping-associated lung disease Syndromic surveillance for e-cigarette, or vaping, product use-associated lung injury Tolerance to hypothermic and antinoceptive effects of ∆9-tetrahydrocannabinol (THC) vapor inhalation in rats Lasting effects of repeated ∆9-tetrahydrocannabinol vapour inhalation during adolescence in male and female rats tree-in-bloom: Severe acute lung injury induced by vaping cannabis oil Pathology of vaping-associated lung injury More on the Pathology of Vaping-Associated Lung Injury Pulmonary lipid-laden macrophages and 5 vaping Vitamin E acetate in bronchoalveolarlavage fluid associated with EVALI A history of vitamin e Vitamin E, antioxidant and nothing more Affinity for α-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs The molecular basis of vitamin E retention: Structure of human α-tocopherol transfer protein α-Tocopherol transfer protein stimulates the secretion of α-tocopherol from a cultured liver cell line through a brefeldin A-insensitive pathway α-Tocopherol transfer protein mediates 20 protective hypercapnia in murine ventilator-induced lung injury Safety assessment of the substance α-tocopherol acetate for use in food contact materials All-rac-α-Tocopherol Acetate Is a Better Vitamin E Source than all-rac-α-Tocopherol Succinate for Broilers The distribution and relative hydrolysis of tocopheryl acetate in the different matrices coexisting in the lumen of the 5 small intestine during digestion could explain its low bioavailability Supercritical fluid-aerosolized vitamin E pretreatment decreases leak in isolated oxidant-perfused rat lungs Aerosol-administered α-tocopherol attenuates lung inflammation in rats given lipopolysaccharide intratracheally Hydrolysis of RRR-αtocopheryl acetate (vitamin E acetate) in the skin and its UV protecting activity (an in vivo 15 study with the rat) Characterization of antioxidant activities of pulmonary surfactant mixtures Type II pneumocytes secrete vitamin E 20 together with surfactant lipids Oxidative stress and antioxidants at biosurfaces: plants, skin, and respiratory tract surfaces Vitamin E: Non-antioxidant roles The rise, the fall and the renaissance of Vitamin E Vitamin E: Emerging aspects and new directions Potential for release of pulmonary toxic ketene from vaping pyrolysis of Vitamin E acetate Hydrogen Bonding between Tetrahydrocannabinol and Vitamin E Acetate in Unvaped, Aerosolized, and Condensed 10 Aerosol e-Liquids Interaction of vitamin E with saturated phospholipid bilayers Modulated phases of phospholipid bilayers induced by tocopherols Targeting cholesterol homeostasis in lung diseases A Unique Case of Secondary Pulmonary Alveolar Proteinosis Following E-Cigarette, or Vaping, Product Use-Associated Lung Injury (EVALI) Studies on lecithin-cholesterol-water interactions by differential scanning calorimetry and X-ray diffraction Calorimetric evidence for the liquid-crystalline state of lipids in a biomembrane Lipid droplet functions beyond energy storage Nonalcoholic fatty liver disease impairs the cytochrome P-450-dependent metabolism of α-tocopherol (vitamin E) Vaping-Associated Acute 10 Respiratory Failure Due to Acute Lipoid Pneumonia However, Vitamin E acetate, given the additional ester moiety, is deprived of the antioxidative property and is markedly more thermostable.
    keywords: acetate; cholesterol; e acetate; evali; lipid; lung; patients; phase; tocopherol; vaping; vitamin; vitamin e
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        item: #47 of 68
          id: cord-321401-w4ne60fn
      author: Schrumpf, Jasmijn A.
       title: Impact of the Local Inflammatory Environment on Mucosal Vitamin D Metabolism and Signaling in Chronic Inflammatory Lung Diseases
        date: 2020-07-10
       words: 10396
      flesch: 19
     summary: The emerging role of extracellular molecular events in sustaining intestinal inflammation Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state Vitamin D enhances production of soluble ST2, inhibiting the action of IL-33 Regulation of immune function by vitamin D and Its use in diseases of immunity Vitamin D in asthma: mechanisms of action and considerations for clinical trials Accelerated ageing of the lung in COPD: new concepts Molecular mechanisms of vitamin D action Klotho: an antiaging protein involved in mineral and vitamin D metabolism Fibroblast growth factor 23 and Klotho contribute to airway inflammation Klotho expression is reduced in COPD airway epithelial cells: effects on inflammation and oxidant injury Critical roles of intestinal epithelial vitamin D receptor signaling in controlling gut mucosal inflammation Imbalance of autophagy and apoptosis in intestinal epithelium lacking the vitamin D receptor Autophagy and inflammation in chronic respiratory disease Autophagy proteins are required for club cell structure and function in airways Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients Vitamin D levels, lung function, and steroid response in adult asthma 25-Hydroxyvitamin D3-deficiency enhances oxidative stress and corticosteroid resistance in severe asthma exacerbation Vitamin D downregulates the IL-23 receptor pathway in human mucosal group 3 innate lymphoid cells Vitamin D counteracts an IL-23-dependent IL-17A(+)IFN-γ(+) response driven by urban particulate matter Comparative effect of 25(OH)D3 and 1,25(OH)2D3 on Th17 cell differentiation Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoidindependent fashion Novel regulation of 25-hydroxyvitamin D3 24-hydroxylase (24(OH)ase) transcription by glucocorticoids: cooperative effects of the glucocorticoid receptor, C/EBPβ, and the Vitamin D receptor in 24(OH)ase transcription Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease Chronic obstructive pulmonary disease Vitamin D enters the circulation either via food intake (plantbased: vitamin D 2 /animal-based: vitamin D 3 ) or as a result of its synthesis in the skin by UVB radiation.
    keywords: 25(oh)d; airway; asthma; cells; chronic; copd; disease; effects; epithelial; exacerbations; expression; inflammatory; levels; lung; patients; vitamin
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        item: #48 of 68
          id: cord-321817-z9oj9nmv
      author: Cereda, Emanuele
       title: Vitamin D supplementation and outcome in COVID-19 patients from the outbreak area of Lombardy, Italy
        date: 2020-11-11
       words: 1490
      flesch: 35
     summary: The involvement of vitamin in the pathophysiology of COVID-19 is still not clear; • Some studies support a link between vitamin D deficiency and worse COVID-19 outcome; • Vitamin D may also enhance macrophages activation and aberrant immune response; • In our study vitamin D supplementation was associated with a trend to higher mortality; • Supplementation trials are crucial to clarify the role of vitamin D in COVID-19. key: cord-321817-z9oj9nmv authors: Cereda, Emanuele; Bogliolo, Laura; Lobascio, Federica; Barichella, Michela; Zecchinelli, Anna Lena; Pezzoli, Gianni; Caccialanza, Ricardo title: Vitamin D supplementation and outcome in COVID-19 patients from the outbreak area of Lombardy, Italy date: 2020-11-11 journal: Nutrition DOI: 10.1016/j.nut.2020.111055 sha: doc_id: 321817 cord_uid: z9oj9nmv • Vitamin D has anti-inflammatory and immunoregulatory functions.
    keywords: covid-19; patients; supplementation; vitamin
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        item: #49 of 68
          id: cord-322866-au76nnzg
      author: Bleizgys, Andrius
       title: Vitamin D and COVID‐19: It is time to act
        date: 2020-10-27
       words: 6039
      flesch: 39
     summary: https://orcid.org/0000-0002-0285-6123 A comprehensive literature review on the clinical presentation, and management of the pandemic coronavirus disease 2019 (COVID-19) Rheumatologists' perspective on coronavirus disease 19 (COVID-19) and potential therapeutic targets COVID-19: the inflammation link and the role of nutrition in potential mitigation Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths Mechanism of inflammatory response in associated comorbidities in COVID-19 The physiology of vitamin D-far more than calcium and bone Vitamin D: extraskeletal health Vitamin D review Worldwide vitamin D status Vitamin D status and nutrition in Europe and Asia Vitamin d status in central europe A global representation of vitamin D status in healthy populations Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue Society Scientific Strabismus' or two related pandemics: coronavirus disease and vitamin D deficiency Vitamin D: drug of the future. Med Hypotheses Role of vitamin D in preventing of COVID-19 infection, progression and severity Vitamin D insufficiency as a potential culprit in critical COVID-19 patients Optimisation of vitamin D status for enhanced immuno-protection against covid-19 Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey Perspective: improving vitamin D status in the management of COVID-19 Lungs as target of COVID-19 infection: Protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment Vitamin D deficiency and air pollution exacerbate COVID-19 through suppression of antiviral peptide LL37.
    keywords: 25oh; covid-19; deficiency; levels; patients; risk; supplementation; vitamin; vitamin d; vitd
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        item: #50 of 68
          id: cord-322899-uxvlagt3
      author: Gorji, Ali
       title: The potential roles of micronutrient deficiency and immune system dysfunction in COVID-19 pandemic
        date: 2020-11-06
       words: 4931
      flesch: 24
     summary: [62] Clinical investigations and in vitro studies have indicated that vitamin A is the main regulator of mucosal immunity and could affect immune responses to mucosal infections. ISRN Infectious Diseases ID 246737 Effects of vitamin a supplementation on immune responses and correlation with clinical outcomes Vitamin-mediated regulation of intestinal immunity High-dose dietary zinc oxide mitigates infection with transmissible gastroenteritis virus in piglets Effects of dietary vitamin A content on antibody responses of feedlot calves inoculated intramuscularly with an inactivated bovine coronavirus vaccine Epithelia-damaging virus infections affect vitamin A status in chickens Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity The effects of vitamin B on the immune/cytokine network and their involvement in depression Vitamin B5 reduces bacterial growth via regulating innate immunity and adaptive immunity in mice infected with Mycobacterium tuberculosis Effects of vitamin B6 deficiency on the composition and functional potential of T cell populations Inflammation, vitamin B6 and related pathways
    keywords: cells; covid-19; deficiency; host; immune; infection; micronutrients; patients; response; system; virus; vitamin; zinc
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        item: #51 of 68
          id: cord-324246-liyk6mna
      author: Shakoor, Hira
       title: Be well: A potential role for vitamin B in COVID-19
        date: 2020-08-15
       words: 2244
      flesch: 35
     summary: Given that, it is plausible that symptoms of vitamin B12 deficiency are close to COVID-19 infection such as elevated oxidative stress and lactate dehydrogenase, hyperhomocysteinemia, coagulation cascade activation, vasoconstriction and renal and pulmonary vasculopathy [28, 31] . Evidence has shown that the mortality rate is higher in COVID-19 patients with low vitamin D concentrations.
    keywords: covid-19; editorial; immune; patients; sars; vitamin
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        item: #52 of 68
          id: cord-324288-qgxswltx
      author: Padhi, Sunali
       title: Lower levels of vitamin D are associated with SARS-CoV-2 infection and mortality in the Indian population: an observational study
        date: 2020-09-14
       words: 3350
      flesch: 14
     summary: Effect on Vitamin D and Calcium Metabolism Status of vitamin D and the associated host factors in pulmonary tuberculosis patients and their household contacts: A cross sectional study Peak bone mineral density of physically active healthy Indian men with adequate nutrition and no known current constraints to bone mineralization Vitamin D Status and Risk of Stroke: The Rotterdam Study Vitamin D insufficiency is associated with abdominal obesity in urban Asian Indians without diabetes in North India Prevalence and functional significance of 25-hydroxyvitamin D deficiency and vitamin D receptor gene polymorphisms in Asian Indians Prevalence and significance of low 25-hydroxyvitamin D concentrations in healthy subjects in Delhi Presence of 25(OH) D deficiency in a rural North Indian village despite abundant sunshine Bone mineral parameters in healthy young Indian adults with optimal vitamin D availability Effect of two different doses of oral cholecalciferol supplementation on serum 25-hydroxy-vitamin D levels in healthy Indian postmenopausal women: A randomized controlled trial Vitamin D and insulin resistance in postmenopausal Indian women A double-blind, randomized, placebo-controlled trial of the shortterm effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally obese men, Diabetic medicine : a journal of the Prevalence of vitamin D deficiency and its relationship with thyroid autoimmunity in Asian Indians: a community-based survey Levels of 25-hydroxy Vitamin D3 and Vitamin D Receptor Polymorphism in Severe Dengue Cases from New Delhi Risk and outcome of multidrug-resistant tuberculosis: vitamin D receptor polymorphisms and serum 25(OH)D, The international journal of tuberculosis and lung disease : the official journal of the International Union against Relationship of levels of Vitamin D with flow-mediated dilatation of brachial artery in patients of myocardial infarction and healthy control: A casecontrol study Level of Vitamin D in hypothyroid subjects: a study on the suburban population of North-West Delhi Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the Absence of vitamin D deficiency among common outdoor workers in Delhi Independent association of severe vitamin D deficiency as a risk of acute myocardial infarction in Indians VDR polymorphism, gene expression and vitamin D levels in leprosy patients from North Indian population Profile of Vitamin D in patients attending at general hospital Mahad India Serum Magnesium and Vitamin D Levels as Indicators of Asthma Severity, Pulmonary medicine 2016 Vitamin D Deficiency in Patients With Chronic Tension-Type Headache: A Case-Control Study Vitamin D deficiency in Healthy Postmenopausal Women in Haryana Correlation of Vitamin D Levels with Pigmentation in Vitiligo Patients Treated with NBUVB Therapy Current Scenario of Prevalence of Vitamin D Deficiency in Ostensibly Healthy Indian Population: A Hospital Based Retrospective Study Vitamin D Status in Cold Trans-Himalayan Deserts at Altitude of 4000 meter and above in India Pattern of 25 hydroxy vitamin D status in North Indian people with newly detected type 2 diabetes: A prospective case control study Serum Vitamin D Levels and Alopecia Areata-A Hospital Based Case-Control Study from North-India Vitamin D status in apparently healthy adults in Kashmir Valley of Indian subcontinent Prevalence of vitamin d deficiency among Indian menopausal women and its correlation with diabetes: A first Indian cross sectional data Combinatorial effect of leptin, tumor necrosis factor-Αlpha, and vitamin d in progression of type 2 diabetes in kashmiri population Vitamin D(3) Level in Women with Uterine Fibroid: An Observational Study in Eastern Indian Population Vitamin D status, hypertension and ischemic stroke: a clinical perspective Serum Vitamin D(3) Levels and Diffuse Hair Fall among the Student Population in South India: A Case-Control Study Low levels of serum Vitamin D in chronic periodontitis patients with type 2 diabetes mellitus: A hospital-based crosssectional clinical study Tuberculosis and vitamin D deficiency Vitamin D Status In Hypertension Vitamin D Levels In Depressive Disorder Association of Vitamin D deficiency and Hypothyroidism in a tertiary teaching hospital in Kerala Comparative study of serum vitamin d levels and other biomarkers in patients attending tertiary cardiac care center Duration of casual sunlight exposure necessary for adequate Vitamin D status in Indian Men Vitamin D status and gestational diabetes mellitus Relationship of lipid parameters with bone mineral density in Indian population Low bone mass in urban Indian women above 40 years of age: prevalence and risk factors Study of bone mineral density in resident doctors working at a teaching hospital Peak bone mineral density and its determinants in an Asian Indian population Study of vitamin D levels and its correlation with insulin resistance Vitamin D as a marker of cognitive decline in elderly Indian population Vitamin D Deficiency : Highly Prevalent Among Apparently Healthy Female Adolescents In Both Urban And Rural Population Of Manipur Vitamin D status and its relationship with systemic lupus erythematosus as a determinant and outcome of disease activity Evaluation of Vitamin D Status and its Impact on Thyroid Related Parameters in New Onset Graves' Disease-A Crosssectional Observational Study Vitamin D status in adult critically ill patients in Eastern India: [136] [137] [138] Note: SARS-CoV-2 data was accessed on 16.08.2020 A new coronavirus associated with human respiratory disease in China Vitamin D and the immune system Vitamin D metabolism, mechanism of action, and clinical applications Vitamin D3: a helpful immuno-modulator Vitamin D and the anti-viral state 25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2 Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study Vitamin D Supplementation in COVID-19 Patients: A Clinical Case Series Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity Serum calcium as a biomarker of clinical severity and prognosis in patients with coronavirus disease Vitamin D and Covid-19:
    keywords: cov-2; indian; levels; patients; population; sars; status; study; vitamin
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        item: #53 of 68
          id: cord-325436-pp3q022y
      author: Alkhatib, Ahmad
       title: Antiviral Functional Foods and Exercise Lifestyle Prevention of Coronavirus
        date: 2020-08-28
       words: 7492
      flesch: 27
     summary: [7] . Increased intake is recommended in high-risk individuals Protein rich foods (e.g., red meat, chicken, seafood) Amino acids and peptides: Anserine, carnosine, taurine, creatine, and 4-hydroxyproline, vitamins, iron, copper Dietary intake of anserine and carnosine promote immunological defence against infections by bacteria, fungi, parasites, and viruses (and coronavirus) through enhanced immune cell functions of monocytes and macrophages Adequate dietary intake, and supplementation of such functional foods, contribute to maintaining optimal levels in the human body, which enhances several aspects of the immune system [7, 45] , and provides an important antiviral prevention of COVID-19
    keywords: acid; activity; cells; covid-19; diabetes; exercise; foods; immune; infections; influenza; intake; lifestyle; prevention; risk; system; virus; vitamin
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        item: #54 of 68
          id: cord-329321-usqjkj89
      author: Chakhtoura, M.
       title: Myths and Facts on Vitamin D Amidst the COVID-19 Pandemic()
        date: 2020-05-26
       words: 2022
      flesch: 37
     summary: They were not used as evidence to derive specific guidance in this commentary Covid-19 -Navigating the Uncharted COVID-19 and African Americans Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID-19) -United States Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions Serum 25-Hydroxyvitamin D levels: Variability, Knowledge Gaps, and the Concept of a Desirable Range Impact of vitamin D supplementation on falls and fractures-A critical appraisal of the quality of the evidence and an overview of the available guidelines The Role of Vitamin D in the Prevention of Coronavirus Disease Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees North-supports vitamin D as a factor determining severity. key: cord-329321-usqjkj89 authors: Chakhtoura, M.; Napoli, N.; Fuleihan, G. El Hajj title: Myths and Facts on Vitamin D Amidst the COVID-19 Pandemic() date: 2020-05-26 journal: Metabolism DOI: 10.1016/j.metabol.2020.154276 sha: doc_id: 329321 cord_uid: usqjkj89 nan Covid-SARS-2 pandemic has struck and spread at light speed, reaching 6 continents within 3 months, transforming our societies globally [1] .
    keywords: covid-19; influenza; patients; supplementation; vitamin
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        item: #55 of 68
          id: cord-329997-jhejhz6d
      author: Muscogiuri, Giovanna
       title: Nutritional recommendations for CoVID-19 quarantine
        date: 2020-04-14
       words: 1270
      flesch: 39
     summary: Many people probably have much of what they might need at home, and so there is no reason to rush to buy groceries creating mass gatherings that could contribute to the spread of CoVID 19 because during quarantine food stores stay open throughout. This desire to consume a specific kind of food is defined as food craving, which is a multidimensional concept including emotional (intense desire to eat), behavioral (seeking food), cognitive (thoughts about food), and physiological (salivation) processes [3] .
    keywords: food; intake; quarantine; risk; vitamin
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        item: #56 of 68
          id: cord-330834-zqm4egei
      author: Drall, Kelsea M.
       title: Vitamin D supplementation in pregnancy and early infancy in relation to gut microbiota composition and C. difficile colonization: implications for viral respiratory infections
        date: 2020-08-11
       words: 4517
      flesch: 26
     summary: Among all infants, infant vitamin D supplementation was associated with a lower abundance of genus Megamonas (q = 0.01) in gut microbiota. The Manitoba site had the lowest prevalence of infant vitamin D supplementation (43.4% overall, 53.4% in exclusively breastfed infants).
    keywords: breastfed; colonization; difficile; gut; infants; maternal; microbiota; study; supplementation; vitamin
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        item: #57 of 68
          id: cord-331191-mq1zwpt7
      author: Mandrioli, Mara
       title: Vitamin D3 in High-Quality Cow Milk: An Italian Case Study
        date: 2020-05-01
       words: 4473
      flesch: 45
     summary: Considering that raw milk needs to be boiled before consumption according to the current Italian regulation, this might further reduce vitamin D3 content due to its possible thermal degradation and consequent reversible isomerization to pre-vitamin D3 [25] . It is a survey about the differences in vitamin D3 content between HQ raw and pasteurized milk with the aim to monitor a representative even if not exhaustive part of the Italian production (particularly from Northern Italy).
    keywords: content; fat; milk; vitamin; vitamin d3
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        item: #58 of 68
          id: cord-332533-iqe6sdq2
      author: Grant, William B.
       title: Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths
        date: 2020-04-02
       words: 8053
      flesch: 35
     summary: Pathophysiology and epidemiology The role of season in the epidemiology of influenza Epidemic influenza and vitamin D On the epidemiology of influenza Temporal relationship between vitamin D status and parathyroid hormone in the United States Influenza virus transmission is dependent on relative humidity and temperature Absolute humidity modulates influenza survival, transmission, and seasonality Absolute humidity and the seasonal onset of influenza in the continental United States Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren Preventive Effects of Vitamin D on Seasonal Influenza A in Infants: A Multicenter, Randomized, Open, Controlled Clinical Trial Effects of vitamin D supplements on influenza A illness during the 2009 H1N1 pandemic: A randomized controlled trial Randomized Trial of Vitamin D Supplementation to Prevent Seasonal Influenza and Upper Respiratory Infection in Patients With Inflammatory Bowel Disease Effect of Vitamin D supplementation to reduce respiratory infections in children and adolescents in Vietnam: A randomized controlled trial. Vitamin D supplementation is required for many individuals to reach 25(OH)D concentrations above 30 ng/mL, especially in winter
    keywords: 25(oh)d; concentrations; covid-19; infection; influenza; patients; risk; serum; studies; supplementation; vitamin; vitamin d
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        item: #59 of 68
          id: cord-333248-5342lyeu
      author: Elenius, Varpu
       title: The relationship of serum vitamins A, D, E and LL-37 levels with allergic status, tonsillar virus detection and immune response
        date: 2017-02-24
       words: 3314
      flesch: 39
     summary: Higher vitamin E levels were associated with lower IL-28 expression (P = 0.016) We found that higher bioavailable 25(OH)D levels were associated with lower prevalence of allergic rhinitis and atopy, higher vitamin E levels with lower prevalence of self-reported allergy, and higher vitamin A showed borderline significance for an association with less respiratory virus detections.
    keywords: expression; fig; levels; ll-37; serum; vitamin
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        item: #60 of 68
          id: cord-335024-0klf75qr
      author: Saponaro, Federica
       title: An Update on Vitamin D Metabolism
        date: 2020-09-08
       words: 9512
      flesch: 37
     summary: Novel ligands and structural insights Epigenome-wide effects of Vitamin D and their impact on the transcriptome of human monocytes involve CTCF Structural aspects of Vitamin D endocrinology Regulation of the vitamin D receptor gene by environment, genetics and epigenetics Epigenetics, cellular memory and gene regulation Nutrigenomics of vitamin D KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells Molecular endocrinology of vitamin D on the epigenome level Structural considerations of vitamin D signaling Minireview: Vitamin D receptor: New assignments for an already busy receptor Extraskeletal actions of vitamin D Key Vitamin D Target Genes with Functions in the Immune System Vitamin D's Effect on Immune Function Modulation of inflammatory and immune responses by vitamin D Vitamin D action: Lessons from VDR and Cyp27b1 null mice Vitamin D Supplementation for the Prevention of Acute Respiratory Tract Infection: A Randomized, Double-Blinded Trial among Young Finnish Men Vitamin D status has a linear association with seasonal infections and lung function in British adults Serum 25-hydroxyvitamin D and the incidence of acute viral respiratory tract infections in healthy adults Cord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis The association between vitamin D deficiency and community-acquired pneumonia Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data A pneumonia outbreak associated with a new coronavirus of probable bat origin Letter: Covid-19, and vitamin D COVID-19 and vitamin D-Is there a link and an opportunity for intervention? Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths Letter: Evidence for Extrarenal Generation of 1,25-Dihydroxyvitamin D Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis Physiologic and pathophysiologic roles of extra renal CYP27b1: Case report and review Regulation of Renal and Extrarenal 1α-Hydroxylase Vitamin D Metabolism Revised: Fall of Dogmas The measurement of vitamin D metabolites: Part I-Metabolism of vitamin D and the measurement of 25-hydroxyvitamin D. Hormones Hereditary hypercalcemia caused by a homozygous pathogenic variant in the cyp24a1 gene: A case report and review of the literature Epimers of vitamin d: A review Progress of liquid chromatography-mass spectrometry in measurement of vitamin D metabolites and analogues Measuring 25-hydroxyvitamin D in a clinical environment: Challenges and needs 25-Hydroxyvitamin D assays: The quest for accuracy Analysis of vitamin D metabolic markers by mass spectrometry: Current techniques, limitations of the gold standard method, and anticipated future directions Mass spectrometric profiling of Vitamin D metabolites beyond 25-hydroxyVitamin D Candidate reference measurement procedures for serum 25-hydroxyvitamin D3and 25-hydroxyvitamin D2by using isotope-dilution liquid chromatography-tandem mass spectrometry Development of a candidate reference measurement procedure for the determination of 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 in human serum using isotope-dilution liquid chromatography-tandem mass spectrometry A candidate reference measurement procedure for quantifying serum concentrations of 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 using isotope-dilution liquid chromatography-tandem mass spectrometry Standardizing vitamin D assays: The way forward NHANES monitoring of serum 25-hydroxyvitamin D: A roundtable summary UK Food Standards Agency Workshop Consensus Report: The choice of method for measuring 25-hydroxyvitamin D to estimate vitamin D status for the UK National Diet and Nutrition Survey Vitamin D metabolite profiling using liquid chromatography-tandem mass spectrometry (LC-MS/MS) Simultaneous profiling of vitamin D metabolites in serum by supercritical fluid chromatography-tandem mass spectrometry Vitamin D Binding Protein: A Historic Overview The multifunctional properties and characteristics of vitamin D-binding protein Vitamin D2 is much less effective than vitamin D3 in humans The free hormone hypothesis: A physiologically based mathematical model Megalin-mediated endocytosis of vitamin D binding protein correlates with 25-hydroxycholecalciferol actions in human mammary cells Vitamin D and DBP:
    keywords: activity; calcium; cells; cyp27b1; cyp2r1; effects; hydroxylase; hydroxyvitamin; levels; metabolism; receptor; regulation; risk; role; system; vdr; vitamin; vitamin d
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        item: #61 of 68
          id: cord-337849-tyabf12r
      author: Greiller, Claire L.
       title: Modulation of the Immune Response to Respiratory Viruses by Vitamin D
        date: 2015-05-29
       words: 9557
      flesch: 23
     summary: In this article, we review the literature reporting results of in vitro experiments investigating immunomodulatory actions of vitamin D metabolites in human respiratory epithelial cells infected with respiratory viruses. Future research: More studies are needed to clarify the effects of vitamin D metabolites on respiratory virus-induced expression of cell surface markers mediating viral entry and bacterial adhesion to respiratory epithelial cells.
    keywords: cells; dihydroxyvitamin; effects; expression; human; infection; inflammatory; influenza; macrophages; production; receptor; response; rsv; virus; viruses; vitamin; vitamin d
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        item: #62 of 68
          id: cord-338140-p88fgojk
      author: Cervantes-Pérez, Enrique
       title: Medical Nutrition Therapy in Hospitalized Patients With SARS-CoV-2 (COVID-19) Infection in a Non-critical Care Setting: Knowledge in Progress
        date: 2020-10-30
       words: 3972
      flesch: 39
     summary: This is because selenium could assist a group of enzymes that, in concert with vitamin E, work to prevent the formation of free radicals and prevent oxidative damage to cells and tissues Vitamin E is a lipid-soluble vitamin that plays an important role in reducing oxidative stress by binding to free radicals as an antioxidant.
    keywords: cells; coronavirus; covid-19; immune; infection; iron; malnutrition; patients; sars; vitamin
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        item: #63 of 68
          id: cord-339166-f7tw90tm
      author: Tecilazich, Francesco
       title: Role of vitamin D in diabetic retinopathy: Pathophysiological and clinical aspects
        date: 2020-10-07
       words: 7004
      flesch: 26
     summary: The vitamin D deficiency pandemic: approaches for diagnosis, treatment and prevention Mechanisms of anabolic therapies for osteoporosis Association between variation of circulating 25-OH vitamin D and methylation of secreted frizzled-related protein 2 in colorectal cancer Obesity and overweight decreases the effect of vitamin D supplementation in adults: systematic review and meta-analysis of randomized controlled trials Vitamin D in physiological and pathological aging: lesson from centenarians Impaired, vitamin D metabolism and response in spontaneously diabetic GK rats Vitamin D metabolism in the chronic streptozotocin-induced diabetic rats New understanding and treatments for osteoporosis Diabetes in Cushing syndrome: basic and clinical aspects Acromegaly and vertebral fractures: facts and questions Serum osteocalcin levels in diabetes mellitus: analysis of the type of diabetes and microvascular complications High prevalence of hypovitaminosis D in female type 2 diabetic population Association of vitamin d with glycemic control in Saudi patients with type 2 diabetes: a retrospective chart review study in an emerging university hospital Association between body fatness and vitamin D 3 status in a postmenopausal population Low vitamin D and risk of type 2 diabetes: a prospective cohort study and metaanalysis Decreased serum concentrations of 25-hydroxycholecalciferol are associated with increased risk of progression to impaired fasting glucose and diabetes Effects of 6-month vitamin D supplementation on insulin sensitivity and secretion: a randomised, placebocontrolled trial Efficacy of vitamin D supplementation on glycemic control in type 2 diabetes patients: a meta-analysis of interventional studies MANAGEMENT OF ENDOCRINE DISEASE: the effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis Vitamin D supplementation in obesity and during weight loss: a review of randomized controlled trials Adiposity, vitamin D requirements, and clinical implications for obesity-related metabolic abnormalities Body mass index predicts resistance to active vitamin D in patients with hypoparathyroidism Vitamin D supplementation and prevention of type 2 diabetes Vitamin D 20,000 IU per week for five years does not prevent progression from prediabetes to diabetes Vitamin D supplementation and musculoskeletal health Vitamin D supplements and prevention of cancer and cardiovascular disease Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies Vitamin D supplementation, serum 25(OH)D concentrations and cardiovascular disease risk factors: a systematic review and meta-analysis 25-Hydroxyvitamin D deficiency is associated with inflammationlinked vascular endothelial dysfunction in middle-aged and older adults Childhood 25-OH vitamin D levels and carotid intima-media thickness in adulthood: the cardiovascular risk in young Finns study Vitamin D promotes vascular regeneration Role of vitamin D in endothelial function and endothelial repair in clinically stable systemic lupus erythematosus Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans Vitamin D3 supplementation for 16 weeks improves flow-mediated dilation in overweight African-American adults Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects Vitamin D and cardiovascular disease: from atherosclerosis to myocardial infarction and stroke Short term effect of captopril on microalbuminuria induced by exercise in normotensive diabetics Long-term treatment with the dual antithromboxane agent picotamide decreases microalbuminuria in normotensive type 2 diabetic patients Role of vitamin D and its analogues in diabetic nephropathy: a meta-analysis Reduced vitamin D levels in painful diabetic peripheral neuropathy Vitamin D for the treatment of painful diabetic neuropathy Prevalence, incidence and future projection of diabetic eye disease in Europe: a systematic review and metaanalysis International Expert, C. International expert committee report on the role of the A1C assay in the diagnosis of diabetes Effect of different diabetes mellitus treatments on functional decline and death in elderly adults with diabetes mellitus The Evolving Treatment of Diabetic Retinopathy Impaired growth hormone (GH) response to pyridostigmine in type 1 diabetic patients with exaggerated GHreleasing hormone-stimulated GH secretion Low-dose octreotide is able to cause a maximal inhibition of the glycemic responses to a mixed meal in obese type 2 diabetic patients treated with insulin Serum 1,25 dihydroxy vitamin D (1,25(OH)2D3), 25 hydroxy vitamin D (25(OH)D) and parathormone levels in diabetic retinopathy Vitamin D deficiency is associated with retinopathy in children and adolescents with type 1 diabetes Glycated hemoglobin A1C and vitamin D and their association with diabetic retinopathy severity Serum levels of vitamin D in diabetic patients with and without retinopathy Lower levels of 25-hydroxyvitamin D3 are associated with a higher prevalence of microvascular complications in patients with type 2 diabetes Vitamin D deficiency is significantly associated with retinopathy in young Japanese type 1 diabetic patients Vitamin D deficiency increases the risk of retinopathy in Chinese patients with type 2 diabetes Adequate vitamin D status is associated with the reduced odds of prevalent diabetic retinopathy in African Americans and Caucasians The association between vitamin D deficiency and diabetic retinopathy in type 2 diabetes: a metaanalysis of observational studies Relationship between vitamin D deficiency and diabetic retinopathy: a meta-analysis Vitamin D levels, microvascular complications, and mortality in type 1 diabetes Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial Vitamin D and retinal microvascular damage: the Rotterdam Study Calcitriol and non-calcemic vitamin D analogue, 22-oxacalcitriol, attenuate developmental and pathological choroidal vasculature angiogenesis ex vivo and in vivo Beneficial effects of the nutritional supplements on the development of diabetic retinopathy Effects of glucan and Vitamin D supplementation on obesity and lipid metabolism in diabetic retinopathy Effects of β-glucan and vitamin D supplementation on inflammatory parameters in patients with diabetic retinopathy Concentration of NK cells after β-glucan and vitamin D supplementation in patients with diabetic retinopathy Effects of vitamin D supplementation on circulatory YKL-40 and MCP-1 biomarkers associated with vascular diabetic complications: a randomized, placebo-controlled, double-blind clinical trial A study of vitamin D supplementation in diabetic retinopathy patients with type 2 diabetes mellitus 25-Hydroxy vitamin D levels and endothelial vasodilator function in normotensive women Low serum vitamin D levels are associated with increased arterial stiffness in youth with type 2 diabetes Vitamin D improves endothelial function in patients with type 2 diabetes mellitus and low vitamin D levels Impaired microvascular endothelial function in vitamin D-deficient diabetic nephropathy patients Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of 1,25-dihydroxyvitamin D3. Vitamin D and human health: lessons from vitamin D receptor null mice Vitamin D assays and the definition of hypovitaminosis D: results from the first international conference on controversies in vitamin D Vitamin D-binding protein: one more piece in the puzzle of acromegalic osteopathy? Glucocorticoid-induced osteoporosis: pathophysiological role of GH/IGF-I and PTH/VITAMIN D axes, treatment options and guidelines Treatment of hypoparathyroidism Skeletal and extra-skeletal actions of vitamin D: current evidence and outstanding questions Consensus statement from 2(nd) international conference on controversies in vitamin D Elimination of vitamin D receptor in vascular endothelial cells alters vascular function Impact of vitamin D on immune function:
    keywords: cells; deficiency; diabetes; diabetic; endothelial; levels; patients; retinopathy; study; supplementation; type; vitamin
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        item: #64 of 68
          id: cord-342335-awu50iev
      author: Carr, Anitra C.
       title: Factors Affecting Vitamin C Status and Prevalence of Deficiency: A Global Health Perspective
        date: 2020-07-01
       words: 8980
      flesch: 46
     summary: Here, we provide a narrative review of potential factors influencing vitamin C status globally. Demographic factors such as sex, age, and race are known to affect vitamin C status, as do socioeconomic factors such as deprivation, education and social class, and institutionalization.
    keywords: c status; concentrations; deficiency; dietary; factors; intake; plasma; prevalence; status; studies; study; vitamin; vitamin c; women
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        item: #65 of 68
          id: cord-343122-lppdauei
      author: Ribeiro, Helena
       title: Does Vitamin D play a role in the management of Covid-19 in Brazil?
        date: 2020-05-22
       words: 2487
      flesch: 31
     summary: The vitamin D deficiency pandemic: approaches for diagnosis, treatment and prevention The risks and benefits of sun exposure The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know Vitamin D supplementation and musculoskeletal health Pulmonary activation of vitamin D3 and preventive effect against interstitial pneumonia Vitamin D alleviates lipopolysaccharideinduced acute lung injury via regulation of the renin-angiotensin system Serum 25-hydroxyvitamin D and the incidence of acute viral respiratory tract infections in healthy adults Prevalence of hypovitaminosis D in elderly women in Italy: clinical consequences and risk factors The importance of vitamin D levels in autoimmune diseases Committee to Review Dietary Reference Intakes for Vitamin D and Calcium Vitamin D in the management of Covid-19 in Brazil Ribeiro H Epidemic influenza and vitamin D Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS) Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin Laboratory confirmation of the effect of occupational sun exposure on serum 25-hydroxyvitamin D concentration Air pollution, environmental chemicals, and smoking may trigger vitamin D deficiency: evidence and potential mechanisms Vitamin D effective ultraviolet wavelengths due to scattering in shade Environmental determinants of previtamin D synthesis in the United Arab Emirates Impact of high latitude, urban living and ethnicity on 25-hydroxyvitamin D status: a need for multidisciplinary action? Decreased bioavailability of vitamin D in obesity Evidence that vitamin d supplementation could reduce risk of influenza and COVID-19 infections and deaths Award received in 2018. Foods such as salmon and other oily fish, cod liver oil, egg yolk, milk and sun-dried mushrooms are natural sources of vitamin D. Vitamin D supplementation and fortified foods such as butter and milk are widely used in countries at high latitude with long winters such as the USA.
    keywords: covid-19; deficiency; diseases; exposure; levels; status; vitamin
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        item: #66 of 68
          id: cord-345120-fa5sx5zm
      author: Simonson, William
       title: Vitamin C and Coronavirus
        date: 2020-05-08
       words: 1854
      flesch: 50
     summary: 6 Dr. Hunninghake reports administering intravenous vitamin C to 250,000 patients over his 31 years of practice and describes vitamin C as The paramount rescue molecule in nature. key: cord-345120-fa5sx5zm authors: Simonson, William title: Vitamin C and Coronavirus date: 2020-05-08 journal:
    keywords: covid-19; patients; study; vitamin
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        item: #67 of 68
          id: cord-348567-rvwxysvc
      author: Panfili, F. M.
       title: Possible role of vitamin D in Covid-19 infection in pediatric population
        date: 2020-06-15
       words: 5402
      flesch: 30
     summary: Vitamin D supplementation, as already described, seems to decrease proinflammatory cytokines in the lung via modulation of both macrophages and T lymphocytes activity [24] . At the moment of writing, an interventional randomized clinical trial has been proposed at the University of Granada, with enrollment of 200 participants, proposing vitamin D supplementations (a single dose of 25,000 UI of vitamin D) in preventing and treating mild forms of suspected Covid-19 [68] .
    keywords: cells; covid-19; disease; levels; patients; pneumonia; role; study; supplementation; vitamin; vitamin d
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        item: #68 of 68
          id: cord-352744-dd2rbsla
      author: Pagano, Maria Teresa
       title: Vitamin D and Sex Differences in COVID-19
        date: 2020-09-30
       words: 1513
      flesch: 22
     summary: However, further studies will be mandatory in order to investigate the efficacy of Vitamin D3 supplements, in combination or not with estrogen agonists, as a valid adjuvant for prevention and/or treatment of this severe infectious disease. Several studies have clearly shown that 1,25(OH)2 vitamin D(3) (Vitamin D3, the active metabolite of vitamin D), besides its classical function in calcium dependent bone homeostasis, is actively involved in the regulation of innate and adaptive immune responses (6) .
    keywords: covid-19; sex; vitamin
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