id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
cord-326013-5i35zdmv	Carpinteiro, Alexander	Pharmacological inhibition of acid sphingomyelinase prevents uptake of SARS-CoV-2 by epithelial cells	2020-10-29		.txt	text/plain	3116	113	37	The tricyclic antidepressant desipramine causes proteolytic degradation of lysosomal sphingomyelinase in human fibroblasts Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model Acid sphingomyelinase/ceramide system mediates effects of antidepressant drugs Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide Emerging mechanisms of drug-induced phospholipidosis Rhinoviruses infect human epithelial cells via ceramide-enriched membrane platforms Ebolavirus requires acid sphingomyelinase activity and plasma membrane sphingomyelin for infection SARS-CoV-2 receptor ACE2 is an Interferonstimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues Increase of heart rate and QTc by Amitripytline, but not by Venlafaxine, is correleated to serum concentration Association between SSRI antidepressant use and reduced risk of intubation or death in hospitalized patients with coronavirus disease 2019: a multicenter retrospective observational study The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2 Quantitative modeling of selective lysosomal targeting for drug design Distribution and fate of C14-amitriptyline in mice and rats Postmortem release of amitriptyline from the lungs; a mechanism of postmortem drug redistribution Postmortem distribution of tramadol, amitriptyline, and their metabolites in a suicidal overdose Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2 Ceramide is upregulated and associated with mortality in patients with chronic heart failure The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases A Vesicular Stomatitis Virus replicon-based bioassay for the rapid and sensitive determination of multispecies type I Interferon Mutations in the spike protein of Middle East respiratory syndrome coronavirus transmitted in Korea increase resistance to antibody-mediated neutralization Here we report that either pharmacological inhibition of acid sphingomyelinase with amitriptyline, imipramine, fluoxetine, sertraline, escitalopram, or maprotiline, or genetic downregulation of the enzyme prevents infection of cultured cells or freshy isolated human nasal epithelial cells with SARS-CoV-2 or pseudoviral pp-VSV-SARS-CoV-2 particles expressing spike, a bona fide system mimicking SARS-CoV-2 infection.	cache/cord-326013-5i35zdmv.txt	txt/cord-326013-5i35zdmv.txt
