id	sid	tid	token	lemma	pos
cord-011435-x73foqu7	1	1	key	key	ADJ
cord-011435-x73foqu7	1	2	:	:	PUNCT
cord-011435-x73foqu7	1	3	cord-011435	cord-011435	PROPN
cord-011435-x73foqu7	1	4	-	-	PUNCT
cord-011435-x73foqu7	1	5	x73foqu7	x73foqu7	PROPN
cord-011435-x73foqu7	1	6	authors	author	NOUN
cord-011435-x73foqu7	1	7	:	:	PUNCT
cord-011435-x73foqu7	1	8	glanz	glanz	PROPN
cord-011435-x73foqu7	1	9	,	,	PUNCT
cord-011435-x73foqu7	1	10	anna	anna	PROPN
cord-011435-x73foqu7	1	11	;	;	PUNCT
cord-011435-x73foqu7	1	12	chawla	chawla	PROPN
cord-011435-x73foqu7	1	13	,	,	PUNCT
cord-011435-x73foqu7	1	14	karan	karan	PROPN
cord-011435-x73foqu7	1	15	;	;	PUNCT
cord-011435-x73foqu7	1	16	fabry	fabry	PROPN
cord-011435-x73foqu7	1	17	,	,	PUNCT
cord-011435-x73foqu7	1	18	stephanie	stephanie	PROPN
cord-011435-x73foqu7	1	19	;	;	PUNCT
cord-011435-x73foqu7	1	20	subramanian	subramanian	PROPN
cord-011435-x73foqu7	1	21	,	,	PUNCT
cord-011435-x73foqu7	1	22	gayatri	gayatri	ADJ
cord-011435-x73foqu7	1	23	;	;	PUNCT
cord-011435-x73foqu7	1	24	garcia	garcia	PROPN
cord-011435-x73foqu7	1	25	,	,	PUNCT
cord-011435-x73foqu7	1	26	julie	julie	PROPN
cord-011435-x73foqu7	1	27	;	;	PUNCT
cord-011435-x73foqu7	1	28	jay	jay	PROPN
cord-011435-x73foqu7	1	29	,	,	PUNCT
cord-011435-x73foqu7	1	30	bryanna	bryanna	PROPN
cord-011435-x73foqu7	1	31	;	;	PUNCT
cord-011435-x73foqu7	1	32	ciricillo	ciricillo	PROPN
cord-011435-x73foqu7	1	33	,	,	PUNCT
cord-011435-x73foqu7	1	34	jacob	jacob	PROPN
cord-011435-x73foqu7	1	35	;	;	PUNCT
cord-011435-x73foqu7	1	36	chakravarti	chakravarti	PROPN
cord-011435-x73foqu7	1	37	,	,	PUNCT
cord-011435-x73foqu7	1	38	ritu	ritu	NOUN
cord-011435-x73foqu7	1	39	;	;	PUNCT
cord-011435-x73foqu7	1	40	taylor	taylor	PROPN
cord-011435-x73foqu7	1	41	,	,	PUNCT
cord-011435-x73foqu7	1	42	r.	r.	PROPN
cord-011435-x73foqu7	1	43	travis	travis	PROPN
cord-011435-x73foqu7	1	44	;	;	PUNCT
cord-011435-x73foqu7	1	45	chattopadhyay	chattopadhyay	PROPN
cord-011435-x73foqu7	1	46	,	,	PUNCT
cord-011435-x73foqu7	1	47	saurabh	saurabh	PROPN
cord-011435-x73foqu7	1	48	title	title	PROPN
cord-011435-x73foqu7	1	49	:	:	PUNCT
cord-011435-x73foqu7	1	50	high	high	ADJ
cord-011435-x73foqu7	1	51	throughput	throughput	NOUN
cord-011435-x73foqu7	1	52	screening	screening	NOUN
cord-011435-x73foqu7	1	53	of	of	ADP
cord-011435-x73foqu7	1	54	fda	fda	PROPN
cord-011435-x73foqu7	1	55	-	-	PUNCT
cord-011435-x73foqu7	1	56	approved	approve	VERB
cord-011435-x73foqu7	1	57	drug	drug	NOUN
cord-011435-x73foqu7	1	58	library	library	NOUN
cord-011435-x73foqu7	1	59	reveals	reveal	VERB
cord-011435-x73foqu7	1	60	the	the	DET
cord-011435-x73foqu7	1	61	compounds	compound	NOUN
cord-011435-x73foqu7	1	62	that	that	PRON
cord-011435-x73foqu7	1	63	promote	promote	VERB
cord-011435-x73foqu7	1	64	irf3	irf3	PROPN
cord-011435-x73foqu7	1	65	-	-	PUNCT
cord-011435-x73foqu7	1	66	mediated	mediate	VERB
cord-011435-x73foqu7	1	67	pro	pro	ADJ
cord-011435-x73foqu7	1	68	-	-	ADJ
cord-011435-x73foqu7	1	69	apoptotic	apoptotic	ADJ
cord-011435-x73foqu7	1	70	pathway	pathway	NOUN
cord-011435-x73foqu7	1	71	inhibit	inhibit	NOUN
cord-011435-x73foqu7	1	72	virus	virus	NOUN
cord-011435-x73foqu7	1	73	replication	replication	NOUN
cord-011435-x73foqu7	1	74	date	date	NOUN
cord-011435-x73foqu7	1	75	:	:	PUNCT
cord-011435-x73foqu7	1	76	2020	2020	NUM
cord-011435-x73foqu7	1	77	-	-	SYM
cord-011435-x73foqu7	1	78	04	04	NUM
cord-011435-x73foqu7	1	79	-	-	PUNCT
cord-011435-x73foqu7	1	80	14	14	NUM
cord-011435-x73foqu7	1	81	journal	journal	NOUN
cord-011435-x73foqu7	1	82	:	:	PUNCT
cord-011435-x73foqu7	1	83	viruses	viruse	VERB
cord-011435-x73foqu7	1	84	doi	doi	PROPN
cord-011435-x73foqu7	1	85	:	:	PUNCT
cord-011435-x73foqu7	1	86	10.3390	10.3390	NUM
cord-011435-x73foqu7	1	87	/	/	SYM
cord-011435-x73foqu7	1	88	v12040442	v12040442	NUM
cord-011435-x73foqu7	1	89	sha	sha	NOUN
cord-011435-x73foqu7	1	90	:	:	PUNCT
cord-011435-x73foqu7	1	91	doc_id	doc_id	X
cord-011435-x73foqu7	1	92	:	:	PUNCT
cord-011435-x73foqu7	1	93	11435	11435	NUM
cord-011435-x73foqu7	1	94	cord_uid	cord_uid	PROPN
cord-011435-x73foqu7	1	95	:	:	PUNCT
cord-011435-x73foqu7	1	96	x73foqu7	x73foqu7	PROPN
cord-011435-x73foqu7	1	97	interferon	interferon	PROPN
cord-011435-x73foqu7	1	98	(	(	PUNCT
cord-011435-x73foqu7	1	99	ifn	ifn	ADJ
cord-011435-x73foqu7	1	100	)	)	PUNCT
cord-011435-x73foqu7	1	101	regulatory	regulatory	ADJ
cord-011435-x73foqu7	1	102	factor	factor	NOUN
cord-011435-x73foqu7	1	103	3	3	NUM
cord-011435-x73foqu7	1	104	(	(	PUNCT
cord-011435-x73foqu7	1	105	irf3	irf3	PROPN
cord-011435-x73foqu7	1	106	)	)	PUNCT
cord-011435-x73foqu7	1	107	is	be	AUX
cord-011435-x73foqu7	1	108	the	the	DET
cord-011435-x73foqu7	1	109	key	key	ADJ
cord-011435-x73foqu7	1	110	transcription	transcription	NOUN
cord-011435-x73foqu7	1	111	factor	factor	NOUN
cord-011435-x73foqu7	1	112	for	for	ADP
cord-011435-x73foqu7	1	113	the	the	DET
cord-011435-x73foqu7	1	114	induction	induction	NOUN
cord-011435-x73foqu7	1	115	of	of	ADP
cord-011435-x73foqu7	1	116	ifn	ifn	ADJ
cord-011435-x73foqu7	1	117	and	and	CCONJ
cord-011435-x73foqu7	1	118	antiviral	antiviral	ADJ
cord-011435-x73foqu7	1	119	genes	gene	NOUN
cord-011435-x73foqu7	1	120	.	.	PUNCT
cord-011435-x73foqu7	2	1	the	the	DET
cord-011435-x73foqu7	2	2	absence	absence	NOUN
cord-011435-x73foqu7	2	3	of	of	ADP
cord-011435-x73foqu7	2	4	antiviral	antiviral	ADJ
cord-011435-x73foqu7	2	5	genes	gene	NOUN
cord-011435-x73foqu7	2	6	in	in	ADP
cord-011435-x73foqu7	2	7	irf3	irf3	PROPN
cord-011435-x73foqu7	2	8	deficiency	deficiency	NOUN
cord-011435-x73foqu7	2	9	leads	lead	VERB
cord-011435-x73foqu7	2	10	to	to	ADP
cord-011435-x73foqu7	2	11	susceptibility	susceptibility	NOUN
cord-011435-x73foqu7	2	12	to	to	ADP
cord-011435-x73foqu7	2	13	a	a	DET
cord-011435-x73foqu7	2	14	wide	wide	ADJ
cord-011435-x73foqu7	2	15	range	range	NOUN
cord-011435-x73foqu7	2	16	of	of	ADP
cord-011435-x73foqu7	2	17	viral	viral	ADJ
cord-011435-x73foqu7	2	18	infections	infection	NOUN
cord-011435-x73foqu7	2	19	.	.	PUNCT
cord-011435-x73foqu7	3	1	previously	previously	ADV
cord-011435-x73foqu7	3	2	,	,	PUNCT
cord-011435-x73foqu7	3	3	we	we	PRON
cord-011435-x73foqu7	3	4	uncovered	uncover	VERB
cord-011435-x73foqu7	3	5	a	a	DET
cord-011435-x73foqu7	3	6	function	function	NOUN
cord-011435-x73foqu7	3	7	for	for	ADP
cord-011435-x73foqu7	3	8	nontranscriptional	nontranscriptional	ADJ
cord-011435-x73foqu7	3	9	irf3	irf3	NOUN
cord-011435-x73foqu7	3	10	(	(	PUNCT
cord-011435-x73foqu7	3	11	nt	nt	PROPN
cord-011435-x73foqu7	3	12	-	-	PUNCT
cord-011435-x73foqu7	3	13	irf3	irf3	PROPN
cord-011435-x73foqu7	3	14	)	)	PUNCT
cord-011435-x73foqu7	3	15	,	,	PUNCT
cord-011435-x73foqu7	3	16	rlr	rlr	NOUN
cord-011435-x73foqu7	3	17	(	(	PUNCT
cord-011435-x73foqu7	3	18	rig	rig	NOUN
cord-011435-x73foqu7	3	19	-	-	PUNCT
cord-011435-x73foqu7	3	20	i	i	NOUN
cord-011435-x73foqu7	3	21	-	-	PUNCT
cord-011435-x73foqu7	3	22	like	like	ADJ
cord-011435-x73foqu7	3	23	receptor)-induced	receptor)-induce	VERB
cord-011435-x73foqu7	3	24	irf3	irf3	NOUN
cord-011435-x73foqu7	3	25	-	-	PUNCT
cord-011435-x73foqu7	3	26	mediated	mediate	VERB
cord-011435-x73foqu7	3	27	pathway	pathway	NOUN
cord-011435-x73foqu7	3	28	of	of	ADP
cord-011435-x73foqu7	3	29	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	3	30	(	(	PUNCT
cord-011435-x73foqu7	3	31	ripa	ripa	PROPN
cord-011435-x73foqu7	3	32	)	)	PUNCT
cord-011435-x73foqu7	3	33	,	,	PUNCT
cord-011435-x73foqu7	3	34	which	which	PRON
cord-011435-x73foqu7	3	35	triggers	trigger	VERB
cord-011435-x73foqu7	3	36	apoptotic	apoptotic	ADJ
cord-011435-x73foqu7	3	37	killing	killing	NOUN
cord-011435-x73foqu7	3	38	of	of	ADP
cord-011435-x73foqu7	3	39	virus	virus	NOUN
cord-011435-x73foqu7	3	40	-	-	PUNCT
cord-011435-x73foqu7	3	41	infected	infect	VERB
cord-011435-x73foqu7	3	42	cells	cell	NOUN
cord-011435-x73foqu7	3	43	.	.	PUNCT
cord-011435-x73foqu7	4	1	using	use	VERB
cord-011435-x73foqu7	4	2	knock	knock	VERB
cord-011435-x73foqu7	4	3	-	-	PUNCT
cord-011435-x73foqu7	4	4	in	in	ADP
cord-011435-x73foqu7	4	5	mice	mouse	NOUN
cord-011435-x73foqu7	4	6	expressing	express	VERB
cord-011435-x73foqu7	4	7	a	a	DET
cord-011435-x73foqu7	4	8	transcriptionally	transcriptionally	ADV
cord-011435-x73foqu7	4	9	inactive	inactive	ADJ
cord-011435-x73foqu7	4	10	,	,	PUNCT
cord-011435-x73foqu7	4	11	but	but	CCONJ
cord-011435-x73foqu7	4	12	ripa	ripa	VERB
cord-011435-x73foqu7	4	13	-	-	PUNCT
cord-011435-x73foqu7	4	14	active	active	ADJ
cord-011435-x73foqu7	4	15	,	,	PUNCT
cord-011435-x73foqu7	4	16	irf3	irf3	PROPN
cord-011435-x73foqu7	4	17	mutant	mutant	NOUN
cord-011435-x73foqu7	4	18	,	,	PUNCT
cord-011435-x73foqu7	4	19	we	we	PRON
cord-011435-x73foqu7	4	20	demonstrated	demonstrate	VERB
cord-011435-x73foqu7	4	21	the	the	DET
cord-011435-x73foqu7	4	22	relative	relative	ADJ
cord-011435-x73foqu7	4	23	contribution	contribution	NOUN
cord-011435-x73foqu7	4	24	of	of	ADP
cord-011435-x73foqu7	4	25	ripa	ripa	NOUN
cord-011435-x73foqu7	4	26	to	to	PART
cord-011435-x73foqu7	4	27	host	host	VERB
cord-011435-x73foqu7	4	28	antiviral	antiviral	ADJ
cord-011435-x73foqu7	4	29	defense	defense	NOUN
cord-011435-x73foqu7	4	30	.	.	PUNCT
cord-011435-x73foqu7	5	1	given	give	VERB
cord-011435-x73foqu7	5	2	that	that	DET
cord-011435-x73foqu7	5	3	ripa	ripa	NOUN
cord-011435-x73foqu7	5	4	is	be	AUX
cord-011435-x73foqu7	5	5	a	a	DET
cord-011435-x73foqu7	5	6	cellular	cellular	ADJ
cord-011435-x73foqu7	5	7	antiviral	antiviral	ADJ
cord-011435-x73foqu7	5	8	pathway	pathway	NOUN
cord-011435-x73foqu7	5	9	,	,	PUNCT
cord-011435-x73foqu7	5	10	we	we	PRON
cord-011435-x73foqu7	5	11	hypothesized	hypothesize	VERB
cord-011435-x73foqu7	5	12	that	that	SCONJ
cord-011435-x73foqu7	5	13	small	small	ADJ
cord-011435-x73foqu7	5	14	molecules	molecule	NOUN
cord-011435-x73foqu7	5	15	that	that	PRON
cord-011435-x73foqu7	5	16	promote	promote	VERB
cord-011435-x73foqu7	5	17	ripa	ripa	NOUN
cord-011435-x73foqu7	5	18	in	in	ADP
cord-011435-x73foqu7	5	19	virus	virus	NOUN
cord-011435-x73foqu7	5	20	-	-	PUNCT
cord-011435-x73foqu7	5	21	infected	infect	VERB
cord-011435-x73foqu7	5	22	cells	cell	NOUN
cord-011435-x73foqu7	5	23	would	would	AUX
cord-011435-x73foqu7	5	24	act	act	VERB
cord-011435-x73foqu7	5	25	as	as	ADP
cord-011435-x73foqu7	5	26	antiviral	antiviral	ADJ
cord-011435-x73foqu7	5	27	agents	agent	NOUN
cord-011435-x73foqu7	5	28	.	.	PUNCT
cord-011435-x73foqu7	6	1	to	to	PART
cord-011435-x73foqu7	6	2	test	test	VERB
cord-011435-x73foqu7	6	3	this	this	PRON
cord-011435-x73foqu7	6	4	,	,	PUNCT
cord-011435-x73foqu7	6	5	we	we	PRON
cord-011435-x73foqu7	6	6	conducted	conduct	VERB
cord-011435-x73foqu7	6	7	a	a	DET
cord-011435-x73foqu7	6	8	high	high	ADJ
cord-011435-x73foqu7	6	9	throughput	throughput	NOUN
cord-011435-x73foqu7	6	10	screen	screen	NOUN
cord-011435-x73foqu7	6	11	of	of	ADP
cord-011435-x73foqu7	6	12	a	a	DET
cord-011435-x73foqu7	6	13	library	library	NOUN
cord-011435-x73foqu7	6	14	of	of	ADP
cord-011435-x73foqu7	6	15	fda	fda	PROPN
cord-011435-x73foqu7	6	16	-	-	PUNCT
cord-011435-x73foqu7	6	17	approved	approve	VERB
cord-011435-x73foqu7	6	18	drugs	drug	NOUN
cord-011435-x73foqu7	6	19	to	to	PART
cord-011435-x73foqu7	6	20	identify	identify	VERB
cord-011435-x73foqu7	6	21	novel	novel	ADJ
cord-011435-x73foqu7	6	22	ripa	ripa	NOUN
cord-011435-x73foqu7	6	23	activators	activator	NOUN
cord-011435-x73foqu7	6	24	.	.	PUNCT
cord-011435-x73foqu7	7	1	our	our	PRON
cord-011435-x73foqu7	7	2	screen	screen	NOUN
cord-011435-x73foqu7	7	3	identified	identify	VERB
cord-011435-x73foqu7	7	4	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	7	5	as	as	ADP
cord-011435-x73foqu7	7	6	a	a	DET
cord-011435-x73foqu7	7	7	potent	potent	ADJ
cord-011435-x73foqu7	7	8	ripa	ripa	NOUN
cord-011435-x73foqu7	7	9	-	-	PUNCT
cord-011435-x73foqu7	7	10	activating	activate	VERB
cord-011435-x73foqu7	7	11	agent	agent	NOUN
cord-011435-x73foqu7	7	12	.	.	PUNCT
cord-011435-x73foqu7	8	1	in	in	ADP
cord-011435-x73foqu7	8	2	support	support	NOUN
cord-011435-x73foqu7	8	3	of	of	ADP
cord-011435-x73foqu7	8	4	our	our	PRON
cord-011435-x73foqu7	8	5	hypothesis	hypothesis	NOUN
cord-011435-x73foqu7	8	6	,	,	PUNCT
cord-011435-x73foqu7	8	7	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	8	8	inhibited	inhibit	VERB
cord-011435-x73foqu7	8	9	the	the	DET
cord-011435-x73foqu7	8	10	replication	replication	NOUN
cord-011435-x73foqu7	8	11	of	of	ADP
cord-011435-x73foqu7	8	12	vesicular	vesicular	ADJ
cord-011435-x73foqu7	8	13	stomatitis	stomatitis	NOUN
cord-011435-x73foqu7	8	14	virus	virus	NOUN
cord-011435-x73foqu7	8	15	,	,	PUNCT
cord-011435-x73foqu7	8	16	a	a	DET
cord-011435-x73foqu7	8	17	model	model	NOUN
cord-011435-x73foqu7	8	18	rhabdovirus	rhabdovirus	NOUN
cord-011435-x73foqu7	8	19	,	,	PUNCT
cord-011435-x73foqu7	8	20	and	and	CCONJ
cord-011435-x73foqu7	8	21	its	its	PRON
cord-011435-x73foqu7	8	22	antiviral	antiviral	ADJ
cord-011435-x73foqu7	8	23	activity	activity	NOUN
cord-011435-x73foqu7	8	24	depended	depend	VERB
cord-011435-x73foqu7	8	25	on	on	ADP
cord-011435-x73foqu7	8	26	its	its	PRON
cord-011435-x73foqu7	8	27	ability	ability	NOUN
cord-011435-x73foqu7	8	28	to	to	PART
cord-011435-x73foqu7	8	29	activate	activate	VERB
cord-011435-x73foqu7	8	30	irf3	irf3	PROPN
cord-011435-x73foqu7	8	31	in	in	ADP
cord-011435-x73foqu7	8	32	ripa	ripa	PROPN
cord-011435-x73foqu7	8	33	.	.	PUNCT
cord-011435-x73foqu7	9	1	surprisingly	surprisingly	ADV
cord-011435-x73foqu7	9	2	,	,	PUNCT
cord-011435-x73foqu7	9	3	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	9	4	inhibited	inhibit	VERB
cord-011435-x73foqu7	9	5	the	the	DET
cord-011435-x73foqu7	9	6	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	9	7	activity	activity	NOUN
cord-011435-x73foqu7	9	8	of	of	ADP
cord-011435-x73foqu7	9	9	irf3	irf3	PROPN
cord-011435-x73foqu7	9	10	.	.	PUNCT
cord-011435-x73foqu7	10	1	the	the	DET
cord-011435-x73foqu7	10	2	antiviral	antiviral	ADJ
cord-011435-x73foqu7	10	3	activity	activity	NOUN
cord-011435-x73foqu7	10	4	of	of	ADP
cord-011435-x73foqu7	10	5	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	10	6	was	be	AUX
cord-011435-x73foqu7	10	7	expanded	expand	VERB
cord-011435-x73foqu7	10	8	to	to	ADP
cord-011435-x73foqu7	10	9	flavivirus	flavivirus	NOUN
cord-011435-x73foqu7	10	10	and	and	CCONJ
cord-011435-x73foqu7	10	11	herpesvirus	herpesvirus	NOUN
cord-011435-x73foqu7	10	12	that	that	PRON
cord-011435-x73foqu7	10	13	also	also	ADV
cord-011435-x73foqu7	10	14	activate	activate	VERB
cord-011435-x73foqu7	10	15	irf3	irf3	PROPN
cord-011435-x73foqu7	10	16	.	.	PUNCT
cord-011435-x73foqu7	11	1	mechanistically	mechanistically	PROPN
cord-011435-x73foqu7	11	2	,	,	PUNCT
cord-011435-x73foqu7	11	3	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	11	4	promoted	promote	VERB
cord-011435-x73foqu7	11	5	ripa	ripa	NOUN
cord-011435-x73foqu7	11	6	by	by	ADP
cord-011435-x73foqu7	11	7	activating	activate	VERB
cord-011435-x73foqu7	11	8	the	the	DET
cord-011435-x73foqu7	11	9	extracellular	extracellular	ADJ
cord-011435-x73foqu7	11	10	signal	signal	NOUN
cord-011435-x73foqu7	11	11	-	-	PUNCT
cord-011435-x73foqu7	11	12	regulated	regulate	VERB
cord-011435-x73foqu7	11	13	kinase	kinase	NOUN
cord-011435-x73foqu7	11	14	(	(	PUNCT
cord-011435-x73foqu7	11	15	erk	erk	PROPN
cord-011435-x73foqu7	11	16	)	)	PUNCT
cord-011435-x73foqu7	11	17	signaling	signal	VERB
cord-011435-x73foqu7	11	18	pathway	pathway	NOUN
cord-011435-x73foqu7	11	19	.	.	PUNCT
cord-011435-x73foqu7	12	1	finally	finally	ADV
cord-011435-x73foqu7	12	2	,	,	PUNCT
cord-011435-x73foqu7	12	3	we	we	PRON
cord-011435-x73foqu7	12	4	validated	validate	VERB
cord-011435-x73foqu7	12	5	these	these	DET
cord-011435-x73foqu7	12	6	results	result	NOUN
cord-011435-x73foqu7	12	7	using	use	VERB
cord-011435-x73foqu7	12	8	another	another	DET
cord-011435-x73foqu7	12	9	ripa	ripa	NOUN
cord-011435-x73foqu7	12	10	-	-	PUNCT
cord-011435-x73foqu7	12	11	activating	activate	VERB
cord-011435-x73foqu7	12	12	compound	compound	NOUN
cord-011435-x73foqu7	12	13	,	,	PUNCT
cord-011435-x73foqu7	12	14	pyrvinium	pyrvinium	PROPN
cord-011435-x73foqu7	12	15	pamoate	pamoate	NOUN
cord-011435-x73foqu7	12	16	,	,	PUNCT
cord-011435-x73foqu7	12	17	which	which	PRON
cord-011435-x73foqu7	12	18	showed	show	VERB
cord-011435-x73foqu7	12	19	a	a	DET
cord-011435-x73foqu7	12	20	similar	similar	ADJ
cord-011435-x73foqu7	12	21	antiviral	antiviral	ADJ
cord-011435-x73foqu7	12	22	effect	effect	NOUN
cord-011435-x73foqu7	12	23	without	without	ADP
cord-011435-x73foqu7	12	24	affecting	affect	VERB
cord-011435-x73foqu7	12	25	the	the	DET
cord-011435-x73foqu7	12	26	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	12	27	activity	activity	NOUN
cord-011435-x73foqu7	12	28	of	of	ADP
cord-011435-x73foqu7	12	29	irf3	irf3	PROPN
cord-011435-x73foqu7	12	30	.	.	PUNCT
cord-011435-x73foqu7	13	1	therefore	therefore	ADV
cord-011435-x73foqu7	13	2	,	,	PUNCT
cord-011435-x73foqu7	13	3	we	we	PRON
cord-011435-x73foqu7	13	4	demonstrate	demonstrate	VERB
cord-011435-x73foqu7	13	5	that	that	SCONJ
cord-011435-x73foqu7	13	6	the	the	DET
cord-011435-x73foqu7	13	7	ripa	ripa	ADJ
cord-011435-x73foqu7	13	8	branch	branch	NOUN
cord-011435-x73foqu7	13	9	of	of	ADP
cord-011435-x73foqu7	13	10	irf3	irf3	PROPN
cord-011435-x73foqu7	13	11	can	can	AUX
cord-011435-x73foqu7	13	12	be	be	AUX
cord-011435-x73foqu7	13	13	targeted	target	VERB
cord-011435-x73foqu7	13	14	therapeutically	therapeutically	ADV
cord-011435-x73foqu7	13	15	to	to	PART
cord-011435-x73foqu7	13	16	prevent	prevent	VERB
cord-011435-x73foqu7	13	17	virus	virus	NOUN
cord-011435-x73foqu7	13	18	infection	infection	NOUN
cord-011435-x73foqu7	13	19	.	.	PUNCT
cord-011435-x73foqu7	14	1	the	the	DET
cord-011435-x73foqu7	14	2	innate	innate	ADJ
cord-011435-x73foqu7	14	3	immune	immune	ADJ
cord-011435-x73foqu7	14	4	response	response	NOUN
cord-011435-x73foqu7	14	5	is	be	AUX
cord-011435-x73foqu7	14	6	the	the	DET
cord-011435-x73foqu7	14	7	first	first	ADJ
cord-011435-x73foqu7	14	8	line	line	NOUN
cord-011435-x73foqu7	14	9	of	of	ADP
cord-011435-x73foqu7	14	10	defense	defense	NOUN
cord-011435-x73foqu7	14	11	against	against	ADP
cord-011435-x73foqu7	14	12	microbial	microbial	ADJ
cord-011435-x73foqu7	14	13	infection	infection	NOUN
cord-011435-x73foqu7	14	14	.	.	PUNCT
cord-011435-x73foqu7	15	1	the	the	DET
cord-011435-x73foqu7	15	2	interferon	interferon	NOUN
cord-011435-x73foqu7	15	3	(	(	PUNCT
cord-011435-x73foqu7	15	4	ifn	ifn	NOUN
cord-011435-x73foqu7	15	5	)	)	PUNCT
cord-011435-x73foqu7	15	6	system	system	NOUN
cord-011435-x73foqu7	15	7	represents	represent	VERB
cord-011435-x73foqu7	15	8	a	a	DET
cord-011435-x73foqu7	15	9	key	key	ADJ
cord-011435-x73foqu7	15	10	antiviral	antiviral	ADJ
cord-011435-x73foqu7	15	11	innate	innate	ADJ
cord-011435-x73foqu7	15	12	immune	immune	ADJ
cord-011435-x73foqu7	15	13	response	response	NOUN
cord-011435-x73foqu7	15	14	mechanism	mechanism	NOUN
cord-011435-x73foqu7	15	15	that	that	PRON
cord-011435-x73foqu7	15	16	dictates	dictate	VERB
cord-011435-x73foqu7	15	17	the	the	DET
cord-011435-x73foqu7	15	18	outcome	outcome	NOUN
cord-011435-x73foqu7	15	19	of	of	ADP
cord-011435-x73foqu7	15	20	a	a	DET
cord-011435-x73foqu7	15	21	viral	viral	ADJ
cord-011435-x73foqu7	15	22	infection	infection	NOUN
cord-011435-x73foqu7	15	23	[	[	X
cord-011435-x73foqu7	15	24	1	1	NUM
cord-011435-x73foqu7	15	25	]	]	PUNCT
cord-011435-x73foqu7	15	26	.	.	PUNCT
cord-011435-x73foqu7	16	1	ifn	ifn	NOUN
cord-011435-x73foqu7	16	2	-	-	PUNCT
cord-011435-x73foqu7	16	3	β	β	PROPN
cord-011435-x73foqu7	16	4	,	,	PUNCT
cord-011435-x73foqu7	16	5	a	a	DET
cord-011435-x73foqu7	16	6	type	type	NOUN
cord-011435-x73foqu7	16	7	-	-	PUNCT
cord-011435-x73foqu7	16	8	i	i	PRON
cord-011435-x73foqu7	16	9	ifn	ifn	NOUN
cord-011435-x73foqu7	16	10	,	,	PUNCT
cord-011435-x73foqu7	16	11	is	be	AUX
cord-011435-x73foqu7	16	12	synthesized	synthesize	VERB
cord-011435-x73foqu7	16	13	in	in	ADP
cord-011435-x73foqu7	16	14	the	the	DET
cord-011435-x73foqu7	16	15	virus	virus	NOUN
cord-011435-x73foqu7	16	16	-	-	PUNCT
cord-011435-x73foqu7	16	17	infected	infect	VERB
cord-011435-x73foqu7	16	18	cells	cell	NOUN
cord-011435-x73foqu7	16	19	by	by	ADP
cord-011435-x73foqu7	16	20	the	the	DET
cord-011435-x73foqu7	16	21	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	16	22	activity	activity	NOUN
cord-011435-x73foqu7	16	23	of	of	ADP
cord-011435-x73foqu7	16	24	ifn	ifn	ADJ
cord-011435-x73foqu7	16	25	regulatory	regulatory	ADJ
cord-011435-x73foqu7	16	26	factor	factor	NOUN
cord-011435-x73foqu7	16	27	3	3	NUM
cord-011435-x73foqu7	16	28	(	(	PUNCT
cord-011435-x73foqu7	16	29	irf3	irf3	PROPN
cord-011435-x73foqu7	16	30	)	)	PUNCT
cord-011435-x73foqu7	17	1	[	[	PUNCT
cord-011435-x73foqu7	17	2	2	2	NUM
cord-011435-x73foqu7	17	3	,	,	PUNCT
cord-011435-x73foqu7	17	4	3	3	NUM
cord-011435-x73foqu7	17	5	]	]	PUNCT
cord-011435-x73foqu7	17	6	.	.	PUNCT
cord-011435-x73foqu7	18	1	irf3	irf3	PROPN
cord-011435-x73foqu7	18	2	remains	remain	VERB
cord-011435-x73foqu7	18	3	as	as	ADP
cord-011435-x73foqu7	18	4	an	an	DET
cord-011435-x73foqu7	18	5	inactive	inactive	ADJ
cord-011435-x73foqu7	18	6	monomer	monomer	NOUN
cord-011435-x73foqu7	18	7	in	in	ADP
cord-011435-x73foqu7	18	8	the	the	DET
cord-011435-x73foqu7	18	9	cytosol	cytosol	NOUN
cord-011435-x73foqu7	18	10	of	of	ADP
cord-011435-x73foqu7	18	11	the	the	DET
cord-011435-x73foqu7	18	12	uninfected	uninfected	ADJ
cord-011435-x73foqu7	18	13	cells	cell	NOUN
cord-011435-x73foqu7	18	14	;	;	PUNCT
cord-011435-x73foqu7	18	15	upon	upon	SCONJ
cord-011435-x73foqu7	18	16	virus	virus	NOUN
cord-011435-x73foqu7	18	17	infection	infection	NOUN
cord-011435-x73foqu7	18	18	,	,	PUNCT
cord-011435-x73foqu7	18	19	it	it	PRON
cord-011435-x73foqu7	18	20	gets	get	AUX
cord-011435-x73foqu7	18	21	phosphorylated	phosphorylate	VERB
cord-011435-x73foqu7	18	22	,	,	PUNCT
cord-011435-x73foqu7	18	23	dimerized	dimerize	VERB
cord-011435-x73foqu7	18	24	,	,	PUNCT
cord-011435-x73foqu7	18	25	and	and	CCONJ
cord-011435-x73foqu7	18	26	translocated	translocate	VERB
cord-011435-x73foqu7	18	27	to	to	ADP
cord-011435-x73foqu7	18	28	the	the	DET
cord-011435-x73foqu7	18	29	nucleus	nucleus	NOUN
cord-011435-x73foqu7	19	1	[	[	PUNCT
cord-011435-x73foqu7	19	2	2	2	NUM
cord-011435-x73foqu7	19	3	,	,	PUNCT
cord-011435-x73foqu7	19	4	4	4	NUM
cord-011435-x73foqu7	19	5	]	]	PUNCT
cord-011435-x73foqu7	19	6	.	.	PUNCT
cord-011435-x73foqu7	20	1	in	in	ADP
cord-011435-x73foqu7	20	2	the	the	DET
cord-011435-x73foqu7	20	3	nucleus	nucleus	NOUN
cord-011435-x73foqu7	20	4	,	,	PUNCT
cord-011435-x73foqu7	20	5	the	the	DET
cord-011435-x73foqu7	20	6	dimeric	dimeric	ADJ
cord-011435-x73foqu7	20	7	irf3	irf3	PROPN
cord-011435-x73foqu7	20	8	binds	bind	VERB
cord-011435-x73foqu7	20	9	to	to	ADP
cord-011435-x73foqu7	20	10	the	the	DET
cord-011435-x73foqu7	20	11	promoters	promoter	NOUN
cord-011435-x73foqu7	20	12	of	of	ADP
cord-011435-x73foqu7	20	13	ifn	ifn	NOUN
cord-011435-x73foqu7	20	14	-	-	PUNCT
cord-011435-x73foqu7	20	15	β	β	NOUN
cord-011435-x73foqu7	20	16	and	and	CCONJ
cord-011435-x73foqu7	20	17	many	many	ADJ
cord-011435-x73foqu7	20	18	ifn	ifn	ADJ
cord-011435-x73foqu7	20	19	-	-	PUNCT
cord-011435-x73foqu7	20	20	stimulated	stimulate	VERB
cord-011435-x73foqu7	20	21	genes	gene	NOUN
cord-011435-x73foqu7	20	22	(	(	PUNCT
cord-011435-x73foqu7	20	23	isgs	isgs	PROPN
cord-011435-x73foqu7	20	24	)	)	PUNCT
cord-011435-x73foqu7	20	25	.	.	PUNCT
cord-011435-x73foqu7	21	1	secreted	secrete	VERB
cord-011435-x73foqu7	21	2	ifns	ifns	NOUN
cord-011435-x73foqu7	21	3	act	act	NOUN
cord-011435-x73foqu7	21	4	via	via	ADP
cord-011435-x73foqu7	21	5	autocrine	autocrine	PROPN
cord-011435-x73foqu7	21	6	and	and	CCONJ
cord-011435-x73foqu7	21	7	paracrine	paracrine	VERB
cord-011435-x73foqu7	21	8	signaling	signal	VERB
cord-011435-x73foqu7	21	9	to	to	PART
cord-011435-x73foqu7	21	10	amplify	amplify	VERB
cord-011435-x73foqu7	21	11	the	the	DET
cord-011435-x73foqu7	21	12	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	21	13	induction	induction	NOUN
cord-011435-x73foqu7	21	14	of	of	ADP
cord-011435-x73foqu7	21	15	hundreds	hundred	NOUN
cord-011435-x73foqu7	21	16	of	of	ADP
cord-011435-x73foqu7	21	17	isgs	isgs	PROPN
cord-011435-x73foqu7	21	18	[	[	PUNCT
cord-011435-x73foqu7	21	19	5	5	NUM
cord-011435-x73foqu7	21	20	]	]	PUNCT
cord-011435-x73foqu7	21	21	.	.	PUNCT
cord-011435-x73foqu7	22	1	the	the	DET
cord-011435-x73foqu7	22	2	isg	isg	PROPN
cord-011435-x73foqu7	22	3	-	-	PUNCT
cord-011435-x73foqu7	22	4	encoded	encode	VERB
cord-011435-x73foqu7	22	5	protein	protein	NOUN
cord-011435-x73foqu7	22	6	products	product	NOUN
cord-011435-x73foqu7	22	7	act	act	VERB
cord-011435-x73foqu7	22	8	on	on	ADP
cord-011435-x73foqu7	22	9	specific	specific	ADJ
cord-011435-x73foqu7	22	10	stages	stage	NOUN
cord-011435-x73foqu7	22	11	of	of	ADP
cord-011435-x73foqu7	22	12	the	the	DET
cord-011435-x73foqu7	22	13	virus	virus	NOUN
cord-011435-x73foqu7	22	14	life	life	NOUN
cord-011435-x73foqu7	22	15	cycle	cycle	NOUN
cord-011435-x73foqu7	22	16	to	to	PART
cord-011435-x73foqu7	22	17	inhibit	inhibit	VERB
cord-011435-x73foqu7	22	18	viral	viral	ADJ
cord-011435-x73foqu7	22	19	replication	replication	NOUN
cord-011435-x73foqu7	22	20	and	and	CCONJ
cord-011435-x73foqu7	22	21	pathogenesis	pathogenesis	NOUN
cord-011435-x73foqu7	22	22	.	.	PUNCT
cord-011435-x73foqu7	23	1	the	the	DET
cord-011435-x73foqu7	23	2	absence	absence	NOUN
cord-011435-x73foqu7	23	3	of	of	ADP
cord-011435-x73foqu7	23	4	antiviral	antiviral	ADJ
cord-011435-x73foqu7	23	5	genes	gene	NOUN
cord-011435-x73foqu7	23	6	in	in	ADP
cord-011435-x73foqu7	23	7	irf3	irf3	PROPN
cord-011435-x73foqu7	23	8	−/−	−/−	NUM
cord-011435-x73foqu7	23	9	mice	mouse	NOUN
cord-011435-x73foqu7	23	10	causes	cause	VERB
cord-011435-x73foqu7	23	11	high	high	ADJ
cord-011435-x73foqu7	23	12	susceptibility	susceptibility	NOUN
cord-011435-x73foqu7	23	13	to	to	ADP
cord-011435-x73foqu7	23	14	a	a	DET
cord-011435-x73foqu7	23	15	wide	wide	ADJ
cord-011435-x73foqu7	23	16	range	range	NOUN
cord-011435-x73foqu7	23	17	of	of	ADP
cord-011435-x73foqu7	23	18	viruses	virus	NOUN
cord-011435-x73foqu7	23	19	[	[	PUNCT
cord-011435-x73foqu7	23	20	6	6	NUM
cord-011435-x73foqu7	23	21	,	,	PUNCT
cord-011435-x73foqu7	23	22	7	7	NUM
cord-011435-x73foqu7	23	23	]	]	PUNCT
cord-011435-x73foqu7	23	24	.	.	PUNCT
cord-011435-x73foqu7	24	1	we	we	PRON
cord-011435-x73foqu7	24	2	have	have	AUX
cord-011435-x73foqu7	24	3	uncovered	uncover	VERB
cord-011435-x73foqu7	24	4	that	that	SCONJ
cord-011435-x73foqu7	24	5	,	,	PUNCT
cord-011435-x73foqu7	24	6	in	in	ADP
cord-011435-x73foqu7	24	7	addition	addition	NOUN
cord-011435-x73foqu7	24	8	to	to	ADP
cord-011435-x73foqu7	24	9	the	the	DET
cord-011435-x73foqu7	24	10	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	24	11	activity	activity	NOUN
cord-011435-x73foqu7	24	12	,	,	PUNCT
cord-011435-x73foqu7	24	13	irf3	irf3	PROPN
cord-011435-x73foqu7	24	14	functions	function	NOUN
cord-011435-x73foqu7	24	15	in	in	ADP
cord-011435-x73foqu7	24	16	a	a	DET
cord-011435-x73foqu7	24	17	nontranscriptional	nontranscriptional	ADJ
cord-011435-x73foqu7	24	18	(	(	PUNCT
cord-011435-x73foqu7	24	19	nt	not	PART
cord-011435-x73foqu7	24	20	)	)	PUNCT
cord-011435-x73foqu7	24	21	pathway	pathway	NOUN
cord-011435-x73foqu7	24	22	in	in	ADP
cord-011435-x73foqu7	24	23	antiviral	antiviral	ADJ
cord-011435-x73foqu7	24	24	defense	defense	NOUN
cord-011435-x73foqu7	24	25	[	[	X
cord-011435-x73foqu7	24	26	8	8	NUM
cord-011435-x73foqu7	24	27	]	]	PUNCT
cord-011435-x73foqu7	24	28	[	[	X
cord-011435-x73foqu7	24	29	9	9	NUM
cord-011435-x73foqu7	24	30	]	]	PUNCT
cord-011435-x73foqu7	24	31	[	[	X
cord-011435-x73foqu7	24	32	10	10	NUM
cord-011435-x73foqu7	24	33	]	]	PUNCT
cord-011435-x73foqu7	24	34	[	[	X
cord-011435-x73foqu7	24	35	11	11	NUM
cord-011435-x73foqu7	24	36	]	]	PUNCT
cord-011435-x73foqu7	24	37	[	[	X
cord-011435-x73foqu7	24	38	12	12	NUM
cord-011435-x73foqu7	24	39	]	]	PUNCT
cord-011435-x73foqu7	24	40	[	[	X
cord-011435-x73foqu7	24	41	13	13	NUM
cord-011435-x73foqu7	24	42	]	]	PUNCT
cord-011435-x73foqu7	24	43	[	[	X
cord-011435-x73foqu7	24	44	14	14	NUM
cord-011435-x73foqu7	24	45	]	]	PUNCT
cord-011435-x73foqu7	24	46	[	[	X
cord-011435-x73foqu7	24	47	15	15	NUM
cord-011435-x73foqu7	24	48	]	]	PUNCT
cord-011435-x73foqu7	24	49	.	.	PUNCT
cord-011435-x73foqu7	25	1	in	in	ADP
cord-011435-x73foqu7	25	2	contrast	contrast	NOUN
cord-011435-x73foqu7	25	3	to	to	ADP
cord-011435-x73foqu7	25	4	the	the	DET
cord-011435-x73foqu7	25	5	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	25	6	pathway	pathway	NOUN
cord-011435-x73foqu7	25	7	,	,	PUNCT
cord-011435-x73foqu7	25	8	nt	nt	PROPN
cord-011435-x73foqu7	25	9	-	-	PUNCT
cord-011435-x73foqu7	25	10	irf3	irf3	PROPN
cord-011435-x73foqu7	25	11	in	in	ADP
cord-011435-x73foqu7	25	12	virus	virus	NOUN
cord-011435-x73foqu7	25	13	-	-	PUNCT
cord-011435-x73foqu7	25	14	infected	infect	VERB
cord-011435-x73foqu7	25	15	cells	cell	NOUN
cord-011435-x73foqu7	25	16	functions	function	NOUN
cord-011435-x73foqu7	25	17	as	as	ADP
cord-011435-x73foqu7	25	18	a	a	DET
cord-011435-x73foqu7	25	19	chaperone	chaperone	NOUN
cord-011435-x73foqu7	25	20	protein	protein	NOUN
cord-011435-x73foqu7	25	21	by	by	ADP
cord-011435-x73foqu7	25	22	translocating	translocate	VERB
cord-011435-x73foqu7	25	23	the	the	DET
cord-011435-x73foqu7	25	24	pro	pro	ADJ
cord-011435-x73foqu7	25	25	-	-	ADJ
cord-011435-x73foqu7	25	26	apoptotic	apoptotic	ADJ
cord-011435-x73foqu7	25	27	protein	protein	NOUN
cord-011435-x73foqu7	25	28	bcl2	bcl2	PROPN
cord-011435-x73foqu7	25	29	-	-	PUNCT
cord-011435-x73foqu7	25	30	associated	associate	VERB
cord-011435-x73foqu7	25	31	x	x	PUNCT
cord-011435-x73foqu7	25	32	(	(	PUNCT
cord-011435-x73foqu7	25	33	bax	bax	PROPN
cord-011435-x73foqu7	25	34	)	)	PUNCT
cord-011435-x73foqu7	25	35	to	to	ADP
cord-011435-x73foqu7	25	36	the	the	DET
cord-011435-x73foqu7	25	37	mitochondria	mitochondria	NOUN
cord-011435-x73foqu7	25	38	,	,	PUNCT
cord-011435-x73foqu7	25	39	thereby	thereby	ADV
cord-011435-x73foqu7	25	40	causing	cause	VERB
cord-011435-x73foqu7	25	41	apoptotic	apoptotic	ADJ
cord-011435-x73foqu7	25	42	cell	cell	NOUN
cord-011435-x73foqu7	25	43	death	death	NOUN
cord-011435-x73foqu7	25	44	,	,	PUNCT
cord-011435-x73foqu7	25	45	which	which	PRON
cord-011435-x73foqu7	25	46	we	we	PRON
cord-011435-x73foqu7	25	47	named	name	VERB
cord-011435-x73foqu7	25	48	rlr	rlr	NOUN
cord-011435-x73foqu7	25	49	(	(	PUNCT
cord-011435-x73foqu7	25	50	rig	rig	NOUN
cord-011435-x73foqu7	25	51	-	-	PUNCT
cord-011435-x73foqu7	25	52	i	i	NOUN
cord-011435-x73foqu7	25	53	-	-	PUNCT
cord-011435-x73foqu7	25	54	like	like	ADJ
cord-011435-x73foqu7	25	55	receptor)-induced	receptor)-induce	VERB
cord-011435-x73foqu7	25	56	irf3	irf3	NOUN
cord-011435-x73foqu7	25	57	-	-	PUNCT
cord-011435-x73foqu7	25	58	mediated	mediate	VERB
cord-011435-x73foqu7	25	59	pathway	pathway	NOUN
cord-011435-x73foqu7	25	60	of	of	ADP
cord-011435-x73foqu7	25	61	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	25	62	(	(	PUNCT
cord-011435-x73foqu7	25	63	ripa	ripa	PROPN
cord-011435-x73foqu7	25	64	)	)	PUNCT
cord-011435-x73foqu7	25	65	(	(	PUNCT
cord-011435-x73foqu7	25	66	figure	figure	NOUN
cord-011435-x73foqu7	25	67	1a	1a	NUM
cord-011435-x73foqu7	25	68	)	)	PUNCT
cord-011435-x73foqu7	26	1	[	[	X
cord-011435-x73foqu7	26	2	7	7	NUM
cord-011435-x73foqu7	26	3	]	]	PUNCT
cord-011435-x73foqu7	26	4	[	[	X
cord-011435-x73foqu7	26	5	8	8	NUM
cord-011435-x73foqu7	26	6	]	]	PUNCT
cord-011435-x73foqu7	26	7	[	[	X
cord-011435-x73foqu7	26	8	9	9	NUM
cord-011435-x73foqu7	26	9	]	]	PUNCT
cord-011435-x73foqu7	26	10	[	[	X
cord-011435-x73foqu7	26	11	10	10	NUM
cord-011435-x73foqu7	26	12	]	]	PUNCT
cord-011435-x73foqu7	26	13	[	[	X
cord-011435-x73foqu7	26	14	11	11	NUM
cord-011435-x73foqu7	26	15	]	]	PUNCT
cord-011435-x73foqu7	26	16	[	[	X
cord-011435-x73foqu7	26	17	12	12	NUM
cord-011435-x73foqu7	26	18	]	]	PUNCT
cord-011435-x73foqu7	26	19	[	[	X
cord-011435-x73foqu7	26	20	13	13	NUM
cord-011435-x73foqu7	26	21	]	]	PUNCT
cord-011435-x73foqu7	26	22	.	.	PUNCT
cord-011435-x73foqu7	27	1	in	in	ADP
cord-011435-x73foqu7	27	2	ripa	ripa	PROPN
cord-011435-x73foqu7	27	3	,	,	PUNCT
cord-011435-x73foqu7	27	4	irf3	irf3	PROPN
cord-011435-x73foqu7	27	5	is	be	AUX
cord-011435-x73foqu7	27	6	activated	activate	VERB
cord-011435-x73foqu7	27	7	by	by	ADP
cord-011435-x73foqu7	27	8	linear	linear	ADJ
cord-011435-x73foqu7	27	9	ubiquitination	ubiquitination	NOUN
cord-011435-x73foqu7	27	10	on	on	ADP
cord-011435-x73foqu7	27	11	two	two	NUM
cord-011435-x73foqu7	27	12	key	key	ADJ
cord-011435-x73foqu7	27	13	lysine	lysine	NOUN
cord-011435-x73foqu7	27	14	residues	residue	NOUN
cord-011435-x73foqu7	27	15	by	by	ADP
cord-011435-x73foqu7	27	16	linear	linear	PROPN
cord-011435-x73foqu7	27	17	ubiquitin	ubiquitin	PROPN
cord-011435-x73foqu7	27	18	chain	chain	PROPN
cord-011435-x73foqu7	27	19	assembly	assembly	NOUN
cord-011435-x73foqu7	27	20	complex	complex	PROPN
cord-011435-x73foqu7	27	21	(	(	PUNCT
cord-011435-x73foqu7	27	22	lubac	lubac	NOUN
cord-011435-x73foqu7	27	23	)	)	PUNCT
cord-011435-x73foqu7	27	24	to	to	PART
cord-011435-x73foqu7	27	25	allow	allow	VERB
cord-011435-x73foqu7	27	26	its	its	PRON
cord-011435-x73foqu7	27	27	interaction	interaction	NOUN
cord-011435-x73foqu7	27	28	with	with	ADP
cord-011435-x73foqu7	27	29	the	the	DET
cord-011435-x73foqu7	27	30	pro	pro	ADJ
cord-011435-x73foqu7	27	31	-	-	ADJ
cord-011435-x73foqu7	27	32	apoptotic	apoptotic	ADJ
cord-011435-x73foqu7	27	33	protein	protein	NOUN
cord-011435-x73foqu7	27	34	bax	bax	PROPN
cord-011435-x73foqu7	28	1	[	[	PUNCT
cord-011435-x73foqu7	28	2	7	7	NUM
cord-011435-x73foqu7	28	3	,	,	PUNCT
cord-011435-x73foqu7	28	4	12	12	NUM
cord-011435-x73foqu7	28	5	]	]	PUNCT
cord-011435-x73foqu7	28	6	.	.	PUNCT
cord-011435-x73foqu7	29	1	the	the	DET
cord-011435-x73foqu7	29	2	irf3	irf3	PROPN
cord-011435-x73foqu7	29	3	/	/	SYM
cord-011435-x73foqu7	29	4	bax	bax	PROPN
cord-011435-x73foqu7	29	5	complex	complex	ADJ
cord-011435-x73foqu7	29	6	translocates	translocate	NOUN
cord-011435-x73foqu7	29	7	to	to	ADP
cord-011435-x73foqu7	29	8	the	the	DET
cord-011435-x73foqu7	29	9	mitochondrial	mitochondrial	ADJ
cord-011435-x73foqu7	29	10	membrane	membrane	NOUN
cord-011435-x73foqu7	29	11	and	and	CCONJ
cord-011435-x73foqu7	29	12	stimulates	stimulate	VERB
cord-011435-x73foqu7	29	13	the	the	DET
cord-011435-x73foqu7	29	14	release	release	NOUN
cord-011435-x73foqu7	29	15	of	of	ADP
cord-011435-x73foqu7	29	16	cytochrome	cytochrome	NOUN
cord-011435-x73foqu7	29	17	c	c	NOUN
cord-011435-x73foqu7	29	18	into	into	ADP
cord-011435-x73foqu7	29	19	the	the	DET
cord-011435-x73foqu7	29	20	cytosol	cytosol	NOUN
cord-011435-x73foqu7	29	21	.	.	PUNCT
cord-011435-x73foqu7	30	1	cytosolic	cytosolic	NOUN
cord-011435-x73foqu7	30	2	cytochrome	cytochrome	NOUN
cord-011435-x73foqu7	30	3	c	c	PROPN
cord-011435-x73foqu7	30	4	activates	activate	VERB
cord-011435-x73foqu7	30	5	cellular	cellular	ADJ
cord-011435-x73foqu7	30	6	caspases	caspase	NOUN
cord-011435-x73foqu7	30	7	to	to	PART
cord-011435-x73foqu7	30	8	trigger	trigger	VERB
cord-011435-x73foqu7	30	9	apoptotic	apoptotic	ADJ
cord-011435-x73foqu7	30	10	cell	cell	NOUN
cord-011435-x73foqu7	30	11	death	death	NOUN
cord-011435-x73foqu7	30	12	(	(	PUNCT
cord-011435-x73foqu7	30	13	figure	figure	NOUN
cord-011435-x73foqu7	30	14	1a	1a	NUM
cord-011435-x73foqu7	30	15	)	)	PUNCT
cord-011435-x73foqu7	30	16	.	.	PUNCT
cord-011435-x73foqu7	31	1	recently	recently	ADV
cord-011435-x73foqu7	31	2	,	,	PUNCT
cord-011435-x73foqu7	31	3	we	we	PRON
cord-011435-x73foqu7	31	4	demonstrated	demonstrate	VERB
cord-011435-x73foqu7	31	5	that	that	SCONJ
cord-011435-x73foqu7	31	6	ripa	ripa	NOUN
cord-011435-x73foqu7	31	7	contributes	contribute	VERB
cord-011435-x73foqu7	31	8	to	to	ADP
cord-011435-x73foqu7	31	9	the	the	DET
cord-011435-x73foqu7	31	10	optimal	optimal	ADJ
cord-011435-x73foqu7	31	11	antiviral	antiviral	ADJ
cord-011435-x73foqu7	31	12	activity	activity	NOUN
cord-011435-x73foqu7	31	13	of	of	ADP
cord-011435-x73foqu7	31	14	irf3	irf3	PROPN
cord-011435-x73foqu7	31	15	.	.	PUNCT
cord-011435-x73foqu7	32	1	knock	knock	VERB
cord-011435-x73foqu7	32	2	-	-	PUNCT
cord-011435-x73foqu7	32	3	in	in	ADP
cord-011435-x73foqu7	32	4	mice	mouse	NOUN
cord-011435-x73foqu7	32	5	expressing	express	VERB
cord-011435-x73foqu7	32	6	a	a	DET
cord-011435-x73foqu7	32	7	ripa	ripa	NOUN
cord-011435-x73foqu7	32	8	-	-	PUNCT
cord-011435-x73foqu7	32	9	active	active	ADJ
cord-011435-x73foqu7	32	10	nt	not	PART
cord-011435-x73foqu7	32	11	-	-	PUNCT
cord-011435-x73foqu7	32	12	irf3	irf3	PROPN
cord-011435-x73foqu7	32	13	mutant	mutant	NOUN
cord-011435-x73foqu7	32	14	(	(	PUNCT
cord-011435-x73foqu7	32	15	irf3	irf3	PROPN
cord-011435-x73foqu7	32	16	s1	s1	PROPN
cord-011435-x73foqu7	32	17	/	/	SYM
cord-011435-x73foqu7	32	18	s1	s1	PROPN
cord-011435-x73foqu7	32	19	)	)	PUNCT
cord-011435-x73foqu7	32	20	can	can	AUX
cord-011435-x73foqu7	32	21	mount	mount	VERB
cord-011435-x73foqu7	32	22	antiviral	antiviral	ADJ
cord-011435-x73foqu7	32	23	protection	protection	NOUN
cord-011435-x73foqu7	32	24	against	against	ADP
cord-011435-x73foqu7	32	25	respiratory	respiratory	ADJ
cord-011435-x73foqu7	32	26	pathogenesis	pathogenesis	NOUN
cord-011435-x73foqu7	32	27	by	by	ADP
cord-011435-x73foqu7	32	28	sendai	sendai	PROPN
cord-011435-x73foqu7	32	29	virus	virus	PROPN
cord-011435-x73foqu7	32	30	(	(	PUNCT
cord-011435-x73foqu7	32	31	sev	sev	X
cord-011435-x73foqu7	32	32	)	)	PUNCT
cord-011435-x73foqu7	32	33	[	[	X
cord-011435-x73foqu7	32	34	7	7	NUM
cord-011435-x73foqu7	32	35	]	]	PUNCT
cord-011435-x73foqu7	32	36	.	.	PUNCT
cord-011435-x73foqu7	33	1	the	the	DET
cord-011435-x73foqu7	33	2	sev	sev	ADV
cord-011435-x73foqu7	33	3	-	-	PUNCT
cord-011435-x73foqu7	33	4	infected	infect	VERB
cord-011435-x73foqu7	33	5	cells	cell	NOUN
cord-011435-x73foqu7	33	6	,	,	PUNCT
cord-011435-x73foqu7	33	7	in	in	ADP
cord-011435-x73foqu7	33	8	the	the	DET
cord-011435-x73foqu7	33	9	absence	absence	NOUN
cord-011435-x73foqu7	33	10	of	of	ADP
cord-011435-x73foqu7	33	11	ripa	ripa	NOUN
cord-011435-x73foqu7	33	12	,	,	PUNCT
cord-011435-x73foqu7	33	13	establish	establish	VERB
cord-011435-x73foqu7	33	14	viral	viral	ADJ
cord-011435-x73foqu7	33	15	persistence	persistence	NOUN
cord-011435-x73foqu7	33	16	[	[	PUNCT
cord-011435-x73foqu7	33	17	14	14	NUM
cord-011435-x73foqu7	33	18	]	]	PUNCT
cord-011435-x73foqu7	33	19	.	.	PUNCT
cord-011435-x73foqu7	34	1	sev	sev	X
cord-011435-x73foqu7	34	2	temporarily	temporarily	ADV
cord-011435-x73foqu7	34	3	regulates	regulate	VERB
cord-011435-x73foqu7	34	4	ripa	ripa	NOUN
cord-011435-x73foqu7	34	5	by	by	ADP
cord-011435-x73foqu7	34	6	activating	activate	VERB
cord-011435-x73foqu7	34	7	the	the	DET
cord-011435-x73foqu7	34	8	cellular	cellular	ADJ
cord-011435-x73foqu7	34	9	survival	survival	NOUN
cord-011435-x73foqu7	34	10	pathways	pathway	NOUN
cord-011435-x73foqu7	34	11	,	,	PUNCT
cord-011435-x73foqu7	34	12	e.g.	e.g.	ADV
cord-011435-x73foqu7	34	13	,	,	PUNCT
cord-011435-x73foqu7	34	14	the	the	DET
cord-011435-x73foqu7	34	15	phosphatidylinositol	phosphatidylinositol	NOUN
cord-011435-x73foqu7	34	16	3	3	NUM
cord-011435-x73foqu7	34	17	-	-	PUNCT
cord-011435-x73foqu7	34	18	kinase	kinase	NOUN
cord-011435-x73foqu7	34	19	(	(	PUNCT
cord-011435-x73foqu7	34	20	pi3k)-dependent	pi3k)-dependent	PROPN
cord-011435-x73foqu7	34	21	akt	akt	NOUN
cord-011435-x73foqu7	34	22	,	,	PUNCT
cord-011435-x73foqu7	34	23	which	which	PRON
cord-011435-x73foqu7	34	24	stabilizes	stabilize	VERB
cord-011435-x73foqu7	34	25	x	x	X
cord-011435-x73foqu7	34	26	-	-	PUNCT
cord-011435-x73foqu7	34	27	linked	link	VERB
cord-011435-x73foqu7	34	28	inhibitor	inhibitor	NOUN
cord-011435-x73foqu7	34	29	of	of	ADP
cord-011435-x73foqu7	34	30	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	34	31	protein	protein	NOUN
cord-011435-x73foqu7	34	32	(	(	PUNCT
cord-011435-x73foqu7	34	33	xiap	xiap	PROPN
cord-011435-x73foqu7	34	34	)	)	PUNCT
cord-011435-x73foqu7	34	35	,	,	PUNCT
cord-011435-x73foqu7	34	36	an	an	DET
cord-011435-x73foqu7	34	37	inhibitor	inhibitor	NOUN
cord-011435-x73foqu7	34	38	of	of	ADP
cord-011435-x73foqu7	34	39	ripa	ripa	PROPN
cord-011435-x73foqu7	35	1	[	[	X
cord-011435-x73foqu7	35	2	15	15	NUM
cord-011435-x73foqu7	35	3	]	]	PUNCT
cord-011435-x73foqu7	35	4	.	.	PUNCT
cord-011435-x73foqu7	36	1	the	the	DET
cord-011435-x73foqu7	36	2	inhibition	inhibition	NOUN
cord-011435-x73foqu7	36	3	of	of	ADP
cord-011435-x73foqu7	36	4	pi3k	pi3k	PRON
cord-011435-x73foqu7	36	5	rapidly	rapidly	ADV
cord-011435-x73foqu7	36	6	triggers	trigger	VERB
cord-011435-x73foqu7	36	7	ripa	ripa	ADJ
cord-011435-x73foqu7	36	8	to	to	PART
cord-011435-x73foqu7	36	9	kill	kill	VERB
cord-011435-x73foqu7	36	10	the	the	DET
cord-011435-x73foqu7	36	11	virus	virus	NOUN
cord-011435-x73foqu7	36	12	-	-	PUNCT
cord-011435-x73foqu7	36	13	infected	infect	VERB
cord-011435-x73foqu7	36	14	cells	cell	NOUN
cord-011435-x73foqu7	36	15	[	[	PUNCT
cord-011435-x73foqu7	36	16	15	15	NUM
cord-011435-x73foqu7	36	17	]	]	PUNCT
cord-011435-x73foqu7	36	18	.	.	PUNCT
cord-011435-x73foqu7	37	1	in	in	ADP
cord-011435-x73foqu7	37	2	the	the	DET
cord-011435-x73foqu7	37	3	time	time	NOUN
cord-011435-x73foqu7	37	4	since	since	SCONJ
cord-011435-x73foqu7	37	5	we	we	PRON
cord-011435-x73foqu7	37	6	described	describe	VERB
cord-011435-x73foqu7	37	7	a	a	DET
cord-011435-x73foqu7	37	8	function	function	NOUN
cord-011435-x73foqu7	37	9	for	for	ADP
cord-011435-x73foqu7	37	10	nt	nt	PROPN
cord-011435-x73foqu7	37	11	-	-	PUNCT
cord-011435-x73foqu7	37	12	irf3	irf3	PROPN
cord-011435-x73foqu7	37	13	,	,	PUNCT
cord-011435-x73foqu7	37	14	several	several	ADJ
cord-011435-x73foqu7	37	15	studies	study	NOUN
cord-011435-x73foqu7	37	16	have	have	AUX
cord-011435-x73foqu7	37	17	reported	report	VERB
cord-011435-x73foqu7	37	18	ripa	ripa	ADJ
cord-011435-x73foqu7	37	19	-	-	PUNCT
cord-011435-x73foqu7	37	20	like	like	ADJ
cord-011435-x73foqu7	37	21	activities	activity	NOUN
cord-011435-x73foqu7	37	22	in	in	ADP
cord-011435-x73foqu7	37	23	viral	viral	ADJ
cord-011435-x73foqu7	37	24	and	and	CCONJ
cord-011435-x73foqu7	37	25	nonviral	nonviral	ADJ
cord-011435-x73foqu7	37	26	pathogenesis	pathogenesis	NOUN
cord-011435-x73foqu7	37	27	.	.	PUNCT
cord-011435-x73foqu7	38	1	in	in	ADP
cord-011435-x73foqu7	38	2	human	human	ADJ
cord-011435-x73foqu7	38	3	t	t	PROPN
cord-011435-x73foqu7	38	4	cell	cell	NOUN
cord-011435-x73foqu7	38	5	leukemia	leukemia	NOUN
cord-011435-x73foqu7	38	6	virus	virus	NOUN
cord-011435-x73foqu7	38	7	(	(	PUNCT
cord-011435-x73foqu7	38	8	htlv1)-infected	htlv1)-infecte	VERB
cord-011435-x73foqu7	38	9	primary	primary	ADJ
cord-011435-x73foqu7	38	10	monocytes	monocyte	NOUN
cord-011435-x73foqu7	38	11	,	,	PUNCT
cord-011435-x73foqu7	38	12	stimulator	stimulator	NOUN
cord-011435-x73foqu7	38	13	of	of	ADP
cord-011435-x73foqu7	38	14	interferon	interferon	NOUN
cord-011435-x73foqu7	38	15	genes	gene	NOUN
cord-011435-x73foqu7	38	16	(	(	PUNCT
cord-011435-x73foqu7	38	17	sting)-activated	sting)-activated	ADJ
cord-011435-x73foqu7	38	18	irf3	irf3	PROPN
cord-011435-x73foqu7	38	19	interacts	interact	VERB
cord-011435-x73foqu7	38	20	with	with	ADP
cord-011435-x73foqu7	38	21	bax	bax	PROPN
cord-011435-x73foqu7	38	22	to	to	PART
cord-011435-x73foqu7	38	23	cause	cause	VERB
cord-011435-x73foqu7	38	24	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	38	25	.	.	PUNCT
cord-011435-x73foqu7	39	1	the	the	DET
cord-011435-x73foqu7	39	2	irf3	irf3	PROPN
cord-011435-x73foqu7	39	3	/	/	SYM
cord-011435-x73foqu7	39	4	bax	bax	NOUN
cord-011435-x73foqu7	39	5	-	-	PUNCT
cord-011435-x73foqu7	39	6	mediated	mediate	VERB
cord-011435-x73foqu7	39	7	monocyte	monocyte	NOUN
cord-011435-x73foqu7	39	8	cell	cell	NOUN
cord-011435-x73foqu7	39	9	death	death	NOUN
cord-011435-x73foqu7	39	10	prevents	prevent	VERB
cord-011435-x73foqu7	39	11	productive	productive	ADJ
cord-011435-x73foqu7	39	12	htlv1	htlv1	ADJ
cord-011435-x73foqu7	39	13	replication	replication	NOUN
cord-011435-x73foqu7	39	14	[	[	PUNCT
cord-011435-x73foqu7	39	15	16	16	NUM
cord-011435-x73foqu7	39	16	]	]	PUNCT
cord-011435-x73foqu7	39	17	.	.	PUNCT
cord-011435-x73foqu7	40	1	in	in	ADP
cord-011435-x73foqu7	40	2	hepatocytes	hepatocyte	NOUN
cord-011435-x73foqu7	40	3	,	,	PUNCT
cord-011435-x73foqu7	40	4	sting	sting	NOUN
cord-011435-x73foqu7	40	5	-	-	PUNCT
cord-011435-x73foqu7	40	6	activated	activate	VERB
cord-011435-x73foqu7	40	7	irf3	irf3	NOUN
cord-011435-x73foqu7	40	8	causes	cause	VERB
cord-011435-x73foqu7	40	9	alcoholic	alcoholic	ADJ
cord-011435-x73foqu7	40	10	liver	liver	NOUN
cord-011435-x73foqu7	40	11	diseases	disease	NOUN
cord-011435-x73foqu7	40	12	(	(	PUNCT
cord-011435-x73foqu7	40	13	ald	ald	PROPN
cord-011435-x73foqu7	40	14	)	)	PUNCT
cord-011435-x73foqu7	40	15	during	during	ADP
cord-011435-x73foqu7	40	16	chronic	chronic	PROPN
cord-011435-x73foqu7	40	17	ethanol	ethanol	NOUN
cord-011435-x73foqu7	40	18	administration	administration	NOUN
cord-011435-x73foqu7	40	19	in	in	ADP
cord-011435-x73foqu7	40	20	mice	mouse	NOUN
cord-011435-x73foqu7	40	21	[	[	PUNCT
cord-011435-x73foqu7	40	22	17	17	NUM
cord-011435-x73foqu7	40	23	]	]	PUNCT
cord-011435-x73foqu7	40	24	.	.	PUNCT
cord-011435-x73foqu7	41	1	ethanol	ethanol	NOUN
cord-011435-x73foqu7	41	2	administration	administration	NOUN
cord-011435-x73foqu7	41	3	triggers	trigger	VERB
cord-011435-x73foqu7	41	4	endoplasmic	endoplasmic	ADJ
cord-011435-x73foqu7	41	5	reticulum	reticulum	NOUN
cord-011435-x73foqu7	41	6	stress	stress	NOUN
cord-011435-x73foqu7	41	7	,	,	PUNCT
cord-011435-x73foqu7	41	8	which	which	PRON
cord-011435-x73foqu7	41	9	activates	activate	VERB
cord-011435-x73foqu7	41	10	sting	sting	NOUN
cord-011435-x73foqu7	41	11	signaling	signal	VERB
cord-011435-x73foqu7	41	12	to	to	PART
cord-011435-x73foqu7	41	13	enable	enable	VERB
cord-011435-x73foqu7	41	14	an	an	DET
cord-011435-x73foqu7	41	15	interaction	interaction	NOUN
cord-011435-x73foqu7	41	16	between	between	ADP
cord-011435-x73foqu7	41	17	irf3	irf3	PROPN
cord-011435-x73foqu7	41	18	and	and	CCONJ
cord-011435-x73foqu7	41	19	bax	bax	PROPN
cord-011435-x73foqu7	41	20	,	,	PUNCT
cord-011435-x73foqu7	41	21	leading	lead	VERB
cord-011435-x73foqu7	41	22	to	to	ADP
cord-011435-x73foqu7	41	23	hepatocyte	hepatocyte	NOUN
cord-011435-x73foqu7	41	24	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	41	25	.	.	PUNCT
cord-011435-x73foqu7	42	1	a	a	DET
cord-011435-x73foqu7	42	2	subsequent	subsequent	ADJ
cord-011435-x73foqu7	42	3	study	study	NOUN
cord-011435-x73foqu7	42	4	further	far	ADV
cord-011435-x73foqu7	42	5	revealed	reveal	VERB
cord-011435-x73foqu7	42	6	that	that	SCONJ
cord-011435-x73foqu7	42	7	carbon	carbon	NOUN
cord-011435-x73foqu7	42	8	tetrachloride	tetrachloride	NOUN
cord-011435-x73foqu7	42	9	(	(	PUNCT
cord-011435-x73foqu7	42	10	ccl4)-induced	ccl4)-induce	VERB
cord-011435-x73foqu7	42	11	hepatotoxicity	hepatotoxicity	NOUN
cord-011435-x73foqu7	42	12	is	be	AUX
cord-011435-x73foqu7	42	13	caused	cause	VERB
cord-011435-x73foqu7	42	14	by	by	ADP
cord-011435-x73foqu7	42	15	the	the	DET
cord-011435-x73foqu7	42	16	ripa	ripa	ADJ
cord-011435-x73foqu7	42	17	-	-	PUNCT
cord-011435-x73foqu7	42	18	like	like	ADJ
cord-011435-x73foqu7	42	19	activity	activity	NOUN
cord-011435-x73foqu7	42	20	of	of	ADP
cord-011435-x73foqu7	42	21	irf3	irf3	PROPN
cord-011435-x73foqu7	42	22	,	,	PUNCT
cord-011435-x73foqu7	42	23	mediated	mediate	VERB
cord-011435-x73foqu7	42	24	by	by	ADP
cord-011435-x73foqu7	42	25	sting	ste	VERB
cord-011435-x73foqu7	42	26	/	/	SYM
cord-011435-x73foqu7	42	27	irf3	irf3	PROPN
cord-011435-x73foqu7	42	28	/	/	SYM
cord-011435-x73foqu7	42	29	bax	bax	NOUN
cord-011435-x73foqu7	42	30	-	-	PUNCT
cord-011435-x73foqu7	42	31	dependent	dependent	ADJ
cord-011435-x73foqu7	42	32	apoptotic	apoptotic	ADJ
cord-011435-x73foqu7	42	33	pathway	pathway	NOUN
cord-011435-x73foqu7	42	34	.	.	PUNCT
cord-011435-x73foqu7	43	1	to	to	PART
cord-011435-x73foqu7	43	2	further	far	ADV
cord-011435-x73foqu7	43	3	investigate	investigate	VERB
cord-011435-x73foqu7	43	4	the	the	DET
cord-011435-x73foqu7	43	5	role	role	NOUN
cord-011435-x73foqu7	43	6	of	of	ADP
cord-011435-x73foqu7	43	7	ripa	ripa	NOUN
cord-011435-x73foqu7	43	8	in	in	ADP
cord-011435-x73foqu7	43	9	ald	ald	PROPN
cord-011435-x73foqu7	43	10	,	,	PUNCT
cord-011435-x73foqu7	43	11	we	we	PRON
cord-011435-x73foqu7	43	12	used	use	VERB
cord-011435-x73foqu7	43	13	the	the	DET
cord-011435-x73foqu7	43	14	irf3	irf3	PROPN
cord-011435-x73foqu7	43	15	s1	s1	PROPN
cord-011435-x73foqu7	43	16	/	/	SYM
cord-011435-x73foqu7	43	17	s1	s1	PROPN
cord-011435-x73foqu7	43	18	knock	knock	VERB
cord-011435-x73foqu7	43	19	-	-	PUNCT
cord-011435-x73foqu7	43	20	in	in	ADP
cord-011435-x73foqu7	43	21	mice	mouse	NOUN
cord-011435-x73foqu7	43	22	in	in	ADP
cord-011435-x73foqu7	43	23	a	a	DET
cord-011435-x73foqu7	43	24	mouse	mouse	NOUN
cord-011435-x73foqu7	43	25	alcoholic	alcoholic	ADJ
cord-011435-x73foqu7	43	26	hepatitis	hepatitis	NOUN
cord-011435-x73foqu7	43	27	model	model	NOUN
cord-011435-x73foqu7	43	28	to	to	PART
cord-011435-x73foqu7	43	29	show	show	VERB
cord-011435-x73foqu7	43	30	that	that	SCONJ
cord-011435-x73foqu7	43	31	ethanol	ethanol	NOUN
cord-011435-x73foqu7	43	32	administration	administration	NOUN
cord-011435-x73foqu7	43	33	activates	activate	VERB
cord-011435-x73foqu7	43	34	ripa	ripa	NOUN
cord-011435-x73foqu7	43	35	in	in	ADP
cord-011435-x73foqu7	43	36	hepatic	hepatic	ADJ
cord-011435-x73foqu7	43	37	immune	immune	ADJ
cord-011435-x73foqu7	43	38	cells	cell	NOUN
cord-011435-x73foqu7	43	39	.	.	PUNCT
cord-011435-x73foqu7	44	1	since	since	SCONJ
cord-011435-x73foqu7	44	2	the	the	DET
cord-011435-x73foqu7	44	3	immune	immune	ADJ
cord-011435-x73foqu7	44	4	cells	cell	NOUN
cord-011435-x73foqu7	44	5	are	be	AUX
cord-011435-x73foqu7	44	6	necessary	necessary	ADJ
cord-011435-x73foqu7	44	7	for	for	ADP
cord-011435-x73foqu7	44	8	the	the	DET
cord-011435-x73foqu7	44	9	resolution	resolution	NOUN
cord-011435-x73foqu7	44	10	of	of	ADP
cord-011435-x73foqu7	44	11	liver	liver	NOUN
cord-011435-x73foqu7	44	12	injury	injury	NOUN
cord-011435-x73foqu7	44	13	,	,	PUNCT
cord-011435-x73foqu7	44	14	our	our	PRON
cord-011435-x73foqu7	44	15	study	study	NOUN
cord-011435-x73foqu7	44	16	demonstrated	demonstrate	VERB
cord-011435-x73foqu7	44	17	a	a	DET
cord-011435-x73foqu7	44	18	detrimental	detrimental	ADJ
cord-011435-x73foqu7	44	19	role	role	NOUN
cord-011435-x73foqu7	44	20	for	for	ADP
cord-011435-x73foqu7	44	21	ripa	ripa	NOUN
cord-011435-x73foqu7	44	22	in	in	ADP
cord-011435-x73foqu7	44	23	ald	ald	PROPN
cord-011435-x73foqu7	44	24	pathogenesis	pathogenesis	PROPN
cord-011435-x73foqu7	44	25	[	[	X
cord-011435-x73foqu7	44	26	18	18	NUM
cord-011435-x73foqu7	44	27	]	]	PUNCT
cord-011435-x73foqu7	44	28	.	.	PUNCT
cord-011435-x73foqu7	45	1	in	in	ADP
cord-011435-x73foqu7	45	2	contrast	contrast	NOUN
cord-011435-x73foqu7	45	3	,	,	PUNCT
cord-011435-x73foqu7	45	4	irf3	irf3	PROPN
cord-011435-x73foqu7	45	5	s1	s1	PROPN
cord-011435-x73foqu7	45	6	/	/	SYM
cord-011435-x73foqu7	45	7	s1	s1	PROPN
cord-011435-x73foqu7	45	8	mice	mouse	NOUN
cord-011435-x73foqu7	45	9	are	be	AUX
cord-011435-x73foqu7	45	10	protected	protect	VERB
cord-011435-x73foqu7	45	11	in	in	ADP
cord-011435-x73foqu7	45	12	high	high	ADJ
cord-011435-x73foqu7	45	13	-	-	PUNCT
cord-011435-x73foqu7	45	14	fat	fat	NOUN
cord-011435-x73foqu7	45	15	diet	diet	NOUN
cord-011435-x73foqu7	45	16	(	(	PUNCT
cord-011435-x73foqu7	45	17	hfd)-induced	hfd)-induce	VERB
cord-011435-x73foqu7	45	18	liver	liver	NOUN
cord-011435-x73foqu7	45	19	diseases	disease	NOUN
cord-011435-x73foqu7	45	20	by	by	ADP
cord-011435-x73foqu7	45	21	the	the	DET
cord-011435-x73foqu7	45	22	resolution	resolution	NOUN
cord-011435-x73foqu7	45	23	of	of	ADP
cord-011435-x73foqu7	45	24	hepatic	hepatic	ADJ
cord-011435-x73foqu7	45	25	inflammation	inflammation	NOUN
cord-011435-x73foqu7	45	26	[	[	X
cord-011435-x73foqu7	45	27	19	19	NUM
cord-011435-x73foqu7	45	28	]	]	PUNCT
cord-011435-x73foqu7	45	29	.	.	PUNCT
cord-011435-x73foqu7	46	1	the	the	DET
cord-011435-x73foqu7	46	2	involvement	involvement	NOUN
cord-011435-x73foqu7	46	3	of	of	ADP
cord-011435-x73foqu7	46	4	ripa	ripa	NOUN
cord-011435-x73foqu7	46	5	in	in	ADP
cord-011435-x73foqu7	46	6	various	various	ADJ
cord-011435-x73foqu7	46	7	disease	disease	NOUN
cord-011435-x73foqu7	46	8	models	model	NOUN
cord-011435-x73foqu7	46	9	highlights	highlight	VERB
cord-011435-x73foqu7	46	10	its	its	PRON
cord-011435-x73foqu7	46	11	potential	potential	NOUN
cord-011435-x73foqu7	46	12	as	as	ADP
cord-011435-x73foqu7	46	13	a	a	DET
cord-011435-x73foqu7	46	14	therapeutic	therapeutic	ADJ
cord-011435-x73foqu7	46	15	target	target	NOUN
cord-011435-x73foqu7	46	16	.	.	PUNCT
cord-011435-x73foqu7	47	1	to	to	PART
cord-011435-x73foqu7	47	2	test	test	VERB
cord-011435-x73foqu7	47	3	this	this	PRON
cord-011435-x73foqu7	47	4	,	,	PUNCT
cord-011435-x73foqu7	47	5	we	we	PRON
cord-011435-x73foqu7	47	6	took	take	VERB
cord-011435-x73foqu7	47	7	a	a	DET
cord-011435-x73foqu7	47	8	pharmacological	pharmacological	ADJ
cord-011435-x73foqu7	47	9	approach	approach	NOUN
cord-011435-x73foqu7	47	10	to	to	PART
cord-011435-x73foqu7	47	11	isolate	isolate	VERB
cord-011435-x73foqu7	47	12	small	small	ADJ
cord-011435-x73foqu7	47	13	molecule	molecule	NOUN
cord-011435-x73foqu7	47	14	modifiers	modifier	NOUN
cord-011435-x73foqu7	47	15	of	of	ADP
cord-011435-x73foqu7	47	16	ripa	ripa	PROPN
cord-011435-x73foqu7	47	17	.	.	PUNCT
cord-011435-x73foqu7	48	1	in	in	ADP
cord-011435-x73foqu7	48	2	the	the	DET
cord-011435-x73foqu7	48	3	current	current	ADJ
cord-011435-x73foqu7	48	4	study	study	NOUN
cord-011435-x73foqu7	48	5	,	,	PUNCT
cord-011435-x73foqu7	48	6	we	we	PRON
cord-011435-x73foqu7	48	7	performed	perform	VERB
cord-011435-x73foqu7	48	8	a	a	DET
cord-011435-x73foqu7	48	9	high	high	ADJ
cord-011435-x73foqu7	48	10	throughput	throughput	NOUN
cord-011435-x73foqu7	48	11	screen	screen	NOUN
cord-011435-x73foqu7	48	12	of	of	ADP
cord-011435-x73foqu7	48	13	a	a	DET
cord-011435-x73foqu7	48	14	library	library	NOUN
cord-011435-x73foqu7	48	15	of	of	ADP
cord-011435-x73foqu7	48	16	fda	fda	PROPN
cord-011435-x73foqu7	48	17	-	-	PUNCT
cord-011435-x73foqu7	48	18	approved	approve	VERB
cord-011435-x73foqu7	48	19	compounds	compound	NOUN
cord-011435-x73foqu7	48	20	(	(	PUNCT
cord-011435-x73foqu7	48	21	prestwick	prestwick	ADJ
cord-011435-x73foqu7	48	22	chemical	chemical	NOUN
cord-011435-x73foqu7	48	23	)	)	PUNCT
cord-011435-x73foqu7	48	24	,	,	PUNCT
cord-011435-x73foqu7	48	25	and	and	CCONJ
cord-011435-x73foqu7	48	26	isolated	isolate	VERB
cord-011435-x73foqu7	48	27	a	a	DET
cord-011435-x73foqu7	48	28	small	small	ADJ
cord-011435-x73foqu7	48	29	subset	subset	NOUN
cord-011435-x73foqu7	48	30	of	of	ADP
cord-011435-x73foqu7	48	31	ripa	ripa	ADJ
cord-011435-x73foqu7	48	32	-	-	PUNCT
cord-011435-x73foqu7	48	33	promoting	promote	VERB
cord-011435-x73foqu7	48	34	compounds	compound	NOUN
cord-011435-x73foqu7	48	35	.	.	PUNCT
cord-011435-x73foqu7	49	1	using	use	VERB
cord-011435-x73foqu7	49	2	two	two	NUM
cord-011435-x73foqu7	49	3	compounds	compound	NOUN
cord-011435-x73foqu7	49	4	,	,	PUNCT
cord-011435-x73foqu7	49	5	which	which	PRON
cord-011435-x73foqu7	49	6	specifically	specifically	ADV
cord-011435-x73foqu7	49	7	activated	activate	VERB
cord-011435-x73foqu7	49	8	ripa	ripa	NOUN
cord-011435-x73foqu7	49	9	,	,	PUNCT
cord-011435-x73foqu7	49	10	but	but	CCONJ
cord-011435-x73foqu7	49	11	not	not	PART
cord-011435-x73foqu7	49	12	the	the	DET
cord-011435-x73foqu7	49	13	transcriptional	transcriptional	NOUN
cord-011435-x73foqu7	49	14	function	function	NOUN
cord-011435-x73foqu7	49	15	of	of	ADP
cord-011435-x73foqu7	49	16	irf3	irf3	PROPN
cord-011435-x73foqu7	49	17	,	,	PUNCT
cord-011435-x73foqu7	49	18	we	we	PRON
cord-011435-x73foqu7	49	19	demonstrated	demonstrate	VERB
cord-011435-x73foqu7	49	20	that	that	SCONJ
cord-011435-x73foqu7	49	21	therapeutic	therapeutic	ADJ
cord-011435-x73foqu7	49	22	activation	activation	NOUN
cord-011435-x73foqu7	49	23	of	of	ADP
cord-011435-x73foqu7	49	24	the	the	DET
cord-011435-x73foqu7	49	25	ripa	ripa	ADJ
cord-011435-x73foqu7	49	26	branch	branch	NOUN
cord-011435-x73foqu7	49	27	of	of	ADP
cord-011435-x73foqu7	49	28	irf3	irf3	PROPN
cord-011435-x73foqu7	49	29	inhibits	inhibit	VERB
cord-011435-x73foqu7	49	30	virus	virus	NOUN
cord-011435-x73foqu7	49	31	replication	replication	NOUN
cord-011435-x73foqu7	49	32	.	.	PUNCT
cord-011435-x73foqu7	50	1	human	human	ADJ
cord-011435-x73foqu7	50	2	cell	cell	NOUN
cord-011435-x73foqu7	50	3	lines	line	VERB
cord-011435-x73foqu7	50	4	mda	mda	PROPN
cord-011435-x73foqu7	50	5	-	-	PUNCT
cord-011435-x73foqu7	50	6	mb-453	mb-453	NOUN
cord-011435-x73foqu7	50	7	(	(	PUNCT
cord-011435-x73foqu7	50	8	atcc	atcc	PROPN
cord-011435-x73foqu7	50	9	htb-131	htb-131	PROPN
cord-011435-x73foqu7	50	10	)	)	PUNCT
cord-011435-x73foqu7	50	11	,	,	PUNCT
cord-011435-x73foqu7	50	12	ht1080	ht1080	PROPN
cord-011435-x73foqu7	50	13	(	(	PUNCT
cord-011435-x73foqu7	50	14	atcc	atcc	PROPN
cord-011435-x73foqu7	50	15	ccl-121	ccl-121	NOUN
cord-011435-x73foqu7	50	16	)	)	PUNCT
cord-011435-x73foqu7	50	17	,	,	PUNCT
cord-011435-x73foqu7	50	18	and	and	CCONJ
cord-011435-x73foqu7	50	19	a549	a549	PROPN
cord-011435-x73foqu7	50	20	(	(	PUNCT
cord-011435-x73foqu7	50	21	atcc	atcc	PROPN
cord-011435-x73foqu7	50	22	ccl-185	ccl-185	PROPN
cord-011435-x73foqu7	50	23	)	)	PUNCT
cord-011435-x73foqu7	50	24	,	,	PUNCT
cord-011435-x73foqu7	50	25	the	the	DET
cord-011435-x73foqu7	50	26	african	african	ADJ
cord-011435-x73foqu7	50	27	green	green	PROPN
cord-011435-x73foqu7	50	28	monkey	monkey	PROPN
cord-011435-x73foqu7	50	29	cell	cell	NOUN
cord-011435-x73foqu7	50	30	line	line	NOUN
cord-011435-x73foqu7	50	31	vero	vero	PROPN
cord-011435-x73foqu7	50	32	(	(	PUNCT
cord-011435-x73foqu7	50	33	atcc	atcc	PROPN
cord-011435-x73foqu7	50	34	ccl-81	ccl-81	PROPN
cord-011435-x73foqu7	50	35	)	)	PUNCT
cord-011435-x73foqu7	50	36	,	,	PUNCT
cord-011435-x73foqu7	50	37	and	and	CCONJ
cord-011435-x73foqu7	50	38	mouse	mouse	NOUN
cord-011435-x73foqu7	50	39	embryonic	embryonic	NOUN
cord-011435-x73foqu7	50	40	fibroblasts	fibroblast	NOUN
cord-011435-x73foqu7	50	41	(	(	PUNCT
cord-011435-x73foqu7	50	42	mefs	mef	NOUN
cord-011435-x73foqu7	50	43	)	)	PUNCT
cord-011435-x73foqu7	50	44	were	be	AUX
cord-011435-x73foqu7	50	45	maintained	maintain	VERB
cord-011435-x73foqu7	50	46	in	in	ADP
cord-011435-x73foqu7	50	47	dmem	dmem	PROPN
cord-011435-x73foqu7	50	48	containing	contain	VERB
cord-011435-x73foqu7	50	49	10	10	NUM
cord-011435-x73foqu7	50	50	%	%	NOUN
cord-011435-x73foqu7	50	51	fbs	fbs	NOUN
cord-011435-x73foqu7	50	52	,	,	PUNCT
cord-011435-x73foqu7	50	53	penicillin	penicillin	NOUN
cord-011435-x73foqu7	50	54	,	,	PUNCT
cord-011435-x73foqu7	50	55	and	and	CCONJ
cord-011435-x73foqu7	50	56	streptomycin	streptomycin	PROPN
cord-011435-x73foqu7	50	57	.	.	PUNCT
cord-011435-x73foqu7	51	1	all	all	DET
cord-011435-x73foqu7	51	2	cell	cell	NOUN
cord-011435-x73foqu7	51	3	lines	line	NOUN
cord-011435-x73foqu7	51	4	viruses	viruse	VERB
cord-011435-x73foqu7	51	5	2020	2020	NUM
cord-011435-x73foqu7	51	6	,	,	PUNCT
cord-011435-x73foqu7	51	7	12	12	NUM
cord-011435-x73foqu7	51	8	,	,	PUNCT
cord-011435-x73foqu7	51	9	442	442	NUM
cord-011435-x73foqu7	51	10	3	3	NUM
cord-011435-x73foqu7	51	11	of	of	ADP
cord-011435-x73foqu7	51	12	18	18	NUM
cord-011435-x73foqu7	51	13	used	use	VERB
cord-011435-x73foqu7	51	14	in	in	ADP
cord-011435-x73foqu7	51	15	this	this	DET
cord-011435-x73foqu7	51	16	study	study	NOUN
cord-011435-x73foqu7	51	17	were	be	AUX
cord-011435-x73foqu7	51	18	maintained	maintain	VERB
cord-011435-x73foqu7	51	19	in	in	ADP
cord-011435-x73foqu7	51	20	the	the	DET
cord-011435-x73foqu7	51	21	authors	author	NOUN
cord-011435-x73foqu7	51	22	'	'	PART
cord-011435-x73foqu7	51	23	laboratory	laboratory	NOUN
cord-011435-x73foqu7	51	24	.	.	PUNCT
cord-011435-x73foqu7	52	1	expression	expression	NOUN
cord-011435-x73foqu7	52	2	vectors	vector	NOUN
cord-011435-x73foqu7	52	3	of	of	ADP
cord-011435-x73foqu7	52	4	human	human	ADJ
cord-011435-x73foqu7	52	5	irf3	irf3	PROPN
cord-011435-x73foqu7	52	6	and	and	CCONJ
cord-011435-x73foqu7	52	7	irf3	irf3	PROPN
cord-011435-x73foqu7	52	8	-	-	PUNCT
cord-011435-x73foqu7	52	9	k10	k10	PROPN
cord-011435-x73foqu7	52	10	were	be	AUX
cord-011435-x73foqu7	52	11	described	describe	VERB
cord-011435-x73foqu7	52	12	previously	previously	ADV
cord-011435-x73foqu7	52	13	[	[	X
cord-011435-x73foqu7	52	14	7	7	NUM
cord-011435-x73foqu7	52	15	]	]	PUNCT
cord-011435-x73foqu7	52	16	,	,	PUNCT
cord-011435-x73foqu7	52	17	and	and	CCONJ
cord-011435-x73foqu7	52	18	the	the	DET
cord-011435-x73foqu7	52	19	ligands	ligand	NOUN
cord-011435-x73foqu7	52	20	for	for	ADP
cord-011435-x73foqu7	52	21	retinoic	retinoic	NOUN
cord-011435-x73foqu7	52	22	acid	acid	NOUN
cord-011435-x73foqu7	52	23	-	-	PUNCT
cord-011435-x73foqu7	52	24	inducible	inducible	ADJ
cord-011435-x73foqu7	52	25	gene	gene	NOUN
cord-011435-x73foqu7	52	26	-	-	PUNCT
cord-011435-x73foqu7	52	27	i	i	NOUN
cord-011435-x73foqu7	52	28	(	(	PUNCT
cord-011435-x73foqu7	52	29	rig	rig	NOUN
cord-011435-x73foqu7	52	30	-	-	PUNCT
cord-011435-x73foqu7	52	31	i	i	NOUN
cord-011435-x73foqu7	52	32	)	)	PUNCT
cord-011435-x73foqu7	52	33	,	,	PUNCT
cord-011435-x73foqu7	52	34	toll	toll	NOUN
cord-011435-x73foqu7	52	35	-	-	PUNCT
cord-011435-x73foqu7	52	36	like	like	ADJ
cord-011435-x73foqu7	52	37	receptor	receptor	NOUN
cord-011435-x73foqu7	52	38	3	3	NUM
cord-011435-x73foqu7	52	39	(	(	PUNCT
cord-011435-x73foqu7	52	40	tlr3	tlr3	NOUN
cord-011435-x73foqu7	52	41	)	)	PUNCT
cord-011435-x73foqu7	52	42	,	,	PUNCT
cord-011435-x73foqu7	52	43	and	and	CCONJ
cord-011435-x73foqu7	52	44	sting	sting	NOUN
cord-011435-x73foqu7	52	45	have	have	AUX
cord-011435-x73foqu7	52	46	been	be	AUX
cord-011435-x73foqu7	52	47	described	describe	VERB
cord-011435-x73foqu7	52	48	before	before	ADP
cord-011435-x73foqu7	52	49	[	[	PROPN
cord-011435-x73foqu7	52	50	7	7	NUM
cord-011435-x73foqu7	52	51	,	,	PUNCT
cord-011435-x73foqu7	52	52	20	20	NUM
cord-011435-x73foqu7	52	53	]	]	PUNCT
cord-011435-x73foqu7	52	54	.	.	PUNCT
cord-011435-x73foqu7	53	1	the	the	DET
cord-011435-x73foqu7	53	2	fda	fda	PROPN
cord-011435-x73foqu7	53	3	-	-	PUNCT
cord-011435-x73foqu7	53	4	approved	approve	VERB
cord-011435-x73foqu7	53	5	drug	drug	NOUN
cord-011435-x73foqu7	53	6	library	library	NOUN
cord-011435-x73foqu7	53	7	was	be	AUX
cord-011435-x73foqu7	53	8	obtained	obtain	VERB
cord-011435-x73foqu7	53	9	from	from	ADP
cord-011435-x73foqu7	53	10	prestwick	prestwick	PROPN
cord-011435-x73foqu7	53	11	chemical	chemical	NOUN
cord-011435-x73foqu7	53	12	(	(	PUNCT
cord-011435-x73foqu7	53	13	pc	pc	PROPN
cord-011435-x73foqu7	53	14	,	,	PUNCT
cord-011435-x73foqu7	53	15	washington	washington	PROPN
cord-011435-x73foqu7	53	16	,	,	PUNCT
cord-011435-x73foqu7	53	17	dc	dc	PROPN
cord-011435-x73foqu7	53	18	,	,	PUNCT
cord-011435-x73foqu7	53	19	usa	usa	PROPN
cord-011435-x73foqu7	53	20	)	)	PUNCT
cord-011435-x73foqu7	53	21	.	.	PUNCT
cord-011435-x73foqu7	54	1	individual	individual	ADJ
cord-011435-x73foqu7	54	2	chemicals	chemical	NOUN
cord-011435-x73foqu7	54	3	were	be	AUX
cord-011435-x73foqu7	54	4	obtained	obtain	VERB
cord-011435-x73foqu7	54	5	from	from	ADP
cord-011435-x73foqu7	54	6	sigma	sigma	PROPN
cord-011435-x73foqu7	54	7	-	-	PUNCT
cord-011435-x73foqu7	54	8	aldrich	aldrich	PROPN
cord-011435-x73foqu7	54	9	(	(	PUNCT
cord-011435-x73foqu7	54	10	,	,	PUNCT
cord-011435-x73foqu7	54	11	anti	anti	ADJ
cord-011435-x73foqu7	54	12	-	-	ADJ
cord-011435-x73foqu7	54	13	ifit1	ifit1	ADJ
cord-011435-x73foqu7	54	14	(	(	PUNCT
cord-011435-x73foqu7	54	15	described	describe	VERB
cord-011435-x73foqu7	54	16	previously	previously	ADV
cord-011435-x73foqu7	54	17	[	[	X
cord-011435-x73foqu7	54	18	7	7	NUM
cord-011435-x73foqu7	54	19	,	,	PUNCT
cord-011435-x73foqu7	54	20	9	9	NUM
cord-011435-x73foqu7	54	21	]	]	PUNCT
cord-011435-x73foqu7	54	22	)	)	PUNCT
cord-011435-x73foqu7	54	23	,	,	PUNCT
cord-011435-x73foqu7	54	24	anti	anti	ADJ
cord-011435-x73foqu7	54	25	-	-	ADJ
cord-011435-x73foqu7	54	26	ifit3	ifit3	NOUN
cord-011435-x73foqu7	54	27	(	(	PUNCT
cord-011435-x73foqu7	54	28	described	describe	VERB
cord-011435-x73foqu7	54	29	previously	previously	ADV
cord-011435-x73foqu7	54	30	[	[	X
cord-011435-x73foqu7	54	31	7	7	NUM
cord-011435-x73foqu7	54	32	,	,	PUNCT
cord-011435-x73foqu7	54	33	9	9	NUM
cord-011435-x73foqu7	54	34	]	]	PUNCT
cord-011435-x73foqu7	54	35	)	)	PUNCT
cord-011435-x73foqu7	54	36	,	,	PUNCT
cord-011435-x73foqu7	54	37	and	and	CCONJ
cord-011435-x73foqu7	54	38	anti	anti	ADJ
cord-011435-x73foqu7	54	39	-	-	ADJ
cord-011435-x73foqu7	54	40	vsv	vsv	ADJ
cord-011435-x73foqu7	54	41	g	g	NOUN
cord-011435-x73foqu7	54	42	-	-	PUNCT
cord-011435-x73foqu7	54	43	protein	protein	NOUN
cord-011435-x73foqu7	54	44	(	(	PUNCT
cord-011435-x73foqu7	54	45	described	describe	VERB
cord-011435-x73foqu7	54	46	previously	previously	ADV
cord-011435-x73foqu7	54	47	[	[	X
cord-011435-x73foqu7	54	48	21	21	NUM
cord-011435-x73foqu7	54	49	,	,	PUNCT
cord-011435-x73foqu7	54	50	22	22	NUM
cord-011435-x73foqu7	54	51	]	]	PUNCT
cord-011435-x73foqu7	54	52	)	)	PUNCT
cord-011435-x73foqu7	54	53	.	.	PUNCT
cord-011435-x73foqu7	55	1	the	the	DET
cord-011435-x73foqu7	55	2	human	human	ADJ
cord-011435-x73foqu7	55	3	breast	breast	NOUN
cord-011435-x73foqu7	55	4	cancer	cancer	NOUN
cord-011435-x73foqu7	55	5	cell	cell	NOUN
cord-011435-x73foqu7	55	6	line	line	NOUN
cord-011435-x73foqu7	55	7	mda	mda	PROPN
cord-011435-x73foqu7	55	8	-	-	PUNCT
cord-011435-x73foqu7	55	9	mb-453	mb-453	NOUN
cord-011435-x73foqu7	55	10	was	be	AUX
cord-011435-x73foqu7	55	11	used	use	VERB
cord-011435-x73foqu7	55	12	to	to	PART
cord-011435-x73foqu7	55	13	screen	screen	VERB
cord-011435-x73foqu7	55	14	the	the	DET
cord-011435-x73foqu7	55	15	library	library	NOUN
cord-011435-x73foqu7	55	16	of	of	ADP
cord-011435-x73foqu7	55	17	fda	fda	PROPN
cord-011435-x73foqu7	55	18	-	-	PUNCT
cord-011435-x73foqu7	55	19	approved	approve	VERB
cord-011435-x73foqu7	55	20	drugs	drug	NOUN
cord-011435-x73foqu7	55	21	to	to	PART
cord-011435-x73foqu7	55	22	isolate	isolate	VERB
cord-011435-x73foqu7	55	23	the	the	DET
cord-011435-x73foqu7	55	24	regulators	regulator	NOUN
cord-011435-x73foqu7	55	25	of	of	ADP
cord-011435-x73foqu7	55	26	ripa	ripa	PROPN
cord-011435-x73foqu7	55	27	(	(	PUNCT
cord-011435-x73foqu7	55	28	figure	figure	NOUN
cord-011435-x73foqu7	55	29	1f	1f	NUM
cord-011435-x73foqu7	55	30	)	)	PUNCT
cord-011435-x73foqu7	55	31	.	.	PUNCT
cord-011435-x73foqu7	56	1	the	the	DET
cord-011435-x73foqu7	56	2	cells	cell	NOUN
cord-011435-x73foqu7	56	3	were	be	AUX
cord-011435-x73foqu7	56	4	seeded	seed	VERB
cord-011435-x73foqu7	56	5	in	in	ADP
cord-011435-x73foqu7	56	6	96	96	NUM
cord-011435-x73foqu7	56	7	-	-	PUNCT
cord-011435-x73foqu7	56	8	well	well	NOUN
cord-011435-x73foqu7	56	9	black	black	ADJ
cord-011435-x73foqu7	56	10	-	-	PUNCT
cord-011435-x73foqu7	56	11	bottom	bottom	NOUN
cord-011435-x73foqu7	56	12	tissue	tissue	NOUN
cord-011435-x73foqu7	56	13	culture	culture	NOUN
cord-011435-x73foqu7	56	14	plates	plate	NOUN
cord-011435-x73foqu7	56	15	,	,	PUNCT
cord-011435-x73foqu7	56	16	and	and	CCONJ
cord-011435-x73foqu7	56	17	the	the	DET
cord-011435-x73foqu7	56	18	next	next	ADJ
cord-011435-x73foqu7	56	19	day	day	NOUN
cord-011435-x73foqu7	56	20	,	,	PUNCT
cord-011435-x73foqu7	56	21	the	the	DET
cord-011435-x73foqu7	56	22	cells	cell	NOUN
cord-011435-x73foqu7	56	23	were	be	AUX
cord-011435-x73foqu7	56	24	transfected	transfecte	VERB
cord-011435-x73foqu7	56	25	with	with	ADP
cord-011435-x73foqu7	56	26	polyi	polyi	NOUN
cord-011435-x73foqu7	56	27	:	:	PUNCT
cord-011435-x73foqu7	56	28	c	c	X
cord-011435-x73foqu7	56	29	using	use	VERB
cord-011435-x73foqu7	56	30	lipofectamine	lipofectamine	PROPN
cord-011435-x73foqu7	56	31	2000	2000	NUM
cord-011435-x73foqu7	56	32	to	to	PART
cord-011435-x73foqu7	56	33	stimulate	stimulate	VERB
cord-011435-x73foqu7	56	34	ripa	ripa	NOUN
cord-011435-x73foqu7	56	35	.	.	PUNCT
cord-011435-x73foqu7	57	1	after	after	ADP
cord-011435-x73foqu7	57	2	the	the	DET
cord-011435-x73foqu7	57	3	addition	addition	NOUN
cord-011435-x73foqu7	57	4	of	of	ADP
cord-011435-x73foqu7	57	5	the	the	DET
cord-011435-x73foqu7	57	6	transfection	transfection	NOUN
cord-011435-x73foqu7	57	7	complex	complex	NOUN
cord-011435-x73foqu7	57	8	,	,	PUNCT
cord-011435-x73foqu7	57	9	the	the	DET
cord-011435-x73foqu7	57	10	cells	cell	NOUN
cord-011435-x73foqu7	57	11	were	be	AUX
cord-011435-x73foqu7	57	12	immediately	immediately	ADV
cord-011435-x73foqu7	57	13	treated	treat	VERB
cord-011435-x73foqu7	57	14	with	with	ADP
cord-011435-x73foqu7	57	15	either	either	CCONJ
cord-011435-x73foqu7	57	16	dmso	dmso	ADJ
cord-011435-x73foqu7	57	17	(	(	PUNCT
cord-011435-x73foqu7	57	18	vehicle	vehicle	NOUN
cord-011435-x73foqu7	57	19	)	)	PUNCT
cord-011435-x73foqu7	57	20	or	or	CCONJ
cord-011435-x73foqu7	57	21	the	the	DET
cord-011435-x73foqu7	57	22	drug	drug	NOUN
cord-011435-x73foqu7	57	23	library	library	NOUN
cord-011435-x73foqu7	57	24	(	(	PUNCT
cord-011435-x73foqu7	57	25	at	at	ADP
cord-011435-x73foqu7	57	26	20	20	NUM
cord-011435-x73foqu7	57	27	µm	µm	NOUN
cord-011435-x73foqu7	57	28	final	final	ADJ
cord-011435-x73foqu7	57	29	concentration	concentration	NOUN
cord-011435-x73foqu7	57	30	)	)	PUNCT
cord-011435-x73foqu7	57	31	.	.	PUNCT
cord-011435-x73foqu7	58	1	after	after	ADP
cord-011435-x73foqu7	58	2	20	20	NUM
cord-011435-x73foqu7	58	3	h	h	NOUN
cord-011435-x73foqu7	58	4	of	of	ADP
cord-011435-x73foqu7	58	5	the	the	DET
cord-011435-x73foqu7	58	6	ripa	ripa	ADJ
cord-011435-x73foqu7	58	7	stimulation	stimulation	NOUN
cord-011435-x73foqu7	58	8	,	,	PUNCT
cord-011435-x73foqu7	58	9	the	the	DET
cord-011435-x73foqu7	58	10	cells	cell	NOUN
cord-011435-x73foqu7	58	11	were	be	AUX
cord-011435-x73foqu7	58	12	analyzed	analyze	VERB
cord-011435-x73foqu7	58	13	for	for	ADP
cord-011435-x73foqu7	58	14	caspase	caspase	NOUN
cord-011435-x73foqu7	58	15	activity	activity	NOUN
cord-011435-x73foqu7	58	16	using	use	VERB
cord-011435-x73foqu7	58	17	apo	apo	PROPN
cord-011435-x73foqu7	58	18	-	-	PUNCT
cord-011435-x73foqu7	58	19	onetm	onetm	NOUN
cord-011435-x73foqu7	58	20	homogeneous	homogeneous	ADJ
cord-011435-x73foqu7	58	21	caspase-3/7	caspase-3/7	ADJ
cord-011435-x73foqu7	58	22	assay	assay	PROPN
cord-011435-x73foqu7	58	23	(	(	PUNCT
cord-011435-x73foqu7	58	24	promega	promega	PROPN
cord-011435-x73foqu7	58	25	,	,	PUNCT
cord-011435-x73foqu7	58	26	san	san	PROPN
cord-011435-x73foqu7	58	27	luis	luis	PROPN
cord-011435-x73foqu7	58	28	obispo	obispo	PROPN
cord-011435-x73foqu7	58	29	,	,	PUNCT
cord-011435-x73foqu7	58	30	ca	can	AUX
cord-011435-x73foqu7	58	31	,	,	PUNCT
cord-011435-x73foqu7	58	32	usa	usa	PROPN
cord-011435-x73foqu7	58	33	)	)	PUNCT
cord-011435-x73foqu7	58	34	following	follow	VERB
cord-011435-x73foqu7	58	35	the	the	DET
cord-011435-x73foqu7	58	36	manufacturer	manufacturer	NOUN
cord-011435-x73foqu7	58	37	's	's	PART
cord-011435-x73foqu7	58	38	instructions	instruction	NOUN
cord-011435-x73foqu7	58	39	.	.	PUNCT
cord-011435-x73foqu7	59	1	the	the	DET
cord-011435-x73foqu7	59	2	caspase	caspase	NOUN
cord-011435-x73foqu7	59	3	activity	activity	NOUN
cord-011435-x73foqu7	59	4	of	of	ADP
cord-011435-x73foqu7	59	5	the	the	DET
cord-011435-x73foqu7	59	6	vehicle	vehicle	NOUN
cord-011435-x73foqu7	59	7	-	-	PUNCT
cord-011435-x73foqu7	59	8	treated	treat	VERB
cord-011435-x73foqu7	59	9	well	well	ADV
cord-011435-x73foqu7	59	10	was	be	AUX
cord-011435-x73foqu7	59	11	arbitrarily	arbitrarily	ADV
cord-011435-x73foqu7	59	12	considered	consider	VERB
cord-011435-x73foqu7	59	13	as	as	ADP
cord-011435-x73foqu7	59	14	100	100	NUM
cord-011435-x73foqu7	59	15	and	and	CCONJ
cord-011435-x73foqu7	59	16	all	all	DET
cord-011435-x73foqu7	59	17	other	other	ADJ
cord-011435-x73foqu7	59	18	values	value	NOUN
cord-011435-x73foqu7	59	19	were	be	AUX
cord-011435-x73foqu7	59	20	normalized	normalize	VERB
cord-011435-x73foqu7	59	21	to	to	ADP
cord-011435-x73foqu7	59	22	this	this	PRON
cord-011435-x73foqu7	59	23	.	.	PUNCT
cord-011435-x73foqu7	60	1	a	a	DET
cord-011435-x73foqu7	60	2	representative	representative	ADJ
cord-011435-x73foqu7	60	3	drug	drug	NOUN
cord-011435-x73foqu7	60	4	screening	screening	NOUN
cord-011435-x73foqu7	60	5	plate	plate	NOUN
cord-011435-x73foqu7	60	6	is	be	AUX
cord-011435-x73foqu7	60	7	shown	show	VERB
cord-011435-x73foqu7	60	8	in	in	ADP
cord-011435-x73foqu7	60	9	figure	figure	NOUN
cord-011435-x73foqu7	60	10	s1	s1	PROPN
cord-011435-x73foqu7	60	11	.	.	PUNCT
cord-011435-x73foqu7	61	1	the	the	DET
cord-011435-x73foqu7	61	2	normalized	normalized	ADJ
cord-011435-x73foqu7	61	3	caspase	caspase	NOUN
cord-011435-x73foqu7	61	4	activity	activity	NOUN
cord-011435-x73foqu7	61	5	was	be	AUX
cord-011435-x73foqu7	61	6	used	use	VERB
cord-011435-x73foqu7	61	7	to	to	PART
cord-011435-x73foqu7	61	8	calculate	calculate	VERB
cord-011435-x73foqu7	61	9	the	the	DET
cord-011435-x73foqu7	61	10	z	z	NOUN
cord-011435-x73foqu7	61	11	-	-	PUNCT
cord-011435-x73foqu7	61	12	scores	score	NOUN
cord-011435-x73foqu7	61	13	and	and	CCONJ
cord-011435-x73foqu7	61	14	the	the	DET
cord-011435-x73foqu7	61	15	top	top	ADJ
cord-011435-x73foqu7	61	16	25	25	NUM
cord-011435-x73foqu7	61	17	primary	primary	ADJ
cord-011435-x73foqu7	61	18	hits	hit	NOUN
cord-011435-x73foqu7	61	19	were	be	AUX
cord-011435-x73foqu7	61	20	isolated	isolate	VERB
cord-011435-x73foqu7	61	21	for	for	ADP
cord-011435-x73foqu7	61	22	further	further	ADJ
cord-011435-x73foqu7	61	23	validation	validation	NOUN
cord-011435-x73foqu7	61	24	.	.	PUNCT
cord-011435-x73foqu7	62	1	ripa	ripa	ADJ
cord-011435-x73foqu7	62	2	stimulation	stimulation	NOUN
cord-011435-x73foqu7	62	3	was	be	AUX
cord-011435-x73foqu7	62	4	performed	perform	VERB
cord-011435-x73foqu7	62	5	by	by	ADP
cord-011435-x73foqu7	62	6	transfecting	transfecte	VERB
cord-011435-x73foqu7	62	7	the	the	DET
cord-011435-x73foqu7	62	8	cells	cell	NOUN
cord-011435-x73foqu7	62	9	with	with	ADP
cord-011435-x73foqu7	62	10	polyi	polyi	NOUN
cord-011435-x73foqu7	62	11	:	:	PUNCT
cord-011435-x73foqu7	62	12	c	c	X
cord-011435-x73foqu7	62	13	(	(	PUNCT
cord-011435-x73foqu7	62	14	1	1	NUM
cord-011435-x73foqu7	62	15	µg	µg	NOUN
cord-011435-x73foqu7	62	16	if	if	SCONJ
cord-011435-x73foqu7	62	17	not	not	PART
cord-011435-x73foqu7	62	18	indicated	indicate	VERB
cord-011435-x73foqu7	62	19	otherwise	otherwise	ADV
cord-011435-x73foqu7	62	20	in	in	ADP
cord-011435-x73foqu7	62	21	the	the	DET
cord-011435-x73foqu7	62	22	figure	figure	NOUN
cord-011435-x73foqu7	62	23	legends	legend	NOUN
cord-011435-x73foqu7	62	24	)	)	PUNCT
cord-011435-x73foqu7	62	25	using	use	VERB
cord-011435-x73foqu7	62	26	lipofectamine	lipofectamine	PROPN
cord-011435-x73foqu7	62	27	2000	2000	NUM
cord-011435-x73foqu7	62	28	for	for	ADP
cord-011435-x73foqu7	62	29	16	16	NUM
cord-011435-x73foqu7	62	30	-	-	SYM
cord-011435-x73foqu7	62	31	24	24	NUM
cord-011435-x73foqu7	62	32	h	h	NOUN
cord-011435-x73foqu7	62	33	,	,	PUNCT
cord-011435-x73foqu7	62	34	and	and	CCONJ
cord-011435-x73foqu7	62	35	the	the	DET
cord-011435-x73foqu7	62	36	cells	cell	NOUN
cord-011435-x73foqu7	62	37	were	be	AUX
cord-011435-x73foqu7	62	38	either	either	ADV
cord-011435-x73foqu7	62	39	analyzed	analyze	VERB
cord-011435-x73foqu7	62	40	for	for	ADP
cord-011435-x73foqu7	62	41	caspase	caspase	NOUN
cord-011435-x73foqu7	62	42	activity	activity	NOUN
cord-011435-x73foqu7	62	43	or	or	CCONJ
cord-011435-x73foqu7	62	44	cleaved	cleave	VERB
cord-011435-x73foqu7	62	45	parp	parp	NOUN
cord-011435-x73foqu7	62	46	,	,	PUNCT
cord-011435-x73foqu7	62	47	as	as	SCONJ
cord-011435-x73foqu7	62	48	indicated	indicate	VERB
cord-011435-x73foqu7	62	49	in	in	ADP
cord-011435-x73foqu7	62	50	the	the	DET
cord-011435-x73foqu7	62	51	figure	figure	NOUN
cord-011435-x73foqu7	62	52	legends	legend	NOUN
cord-011435-x73foqu7	62	53	.	.	PUNCT
cord-011435-x73foqu7	63	1	for	for	ADP
cord-011435-x73foqu7	63	2	the	the	DET
cord-011435-x73foqu7	63	3	drug	drug	NOUN
cord-011435-x73foqu7	63	4	treatments	treatment	NOUN
cord-011435-x73foqu7	63	5	,	,	PUNCT
cord-011435-x73foqu7	63	6	the	the	DET
cord-011435-x73foqu7	63	7	cells	cell	NOUN
cord-011435-x73foqu7	63	8	were	be	AUX
cord-011435-x73foqu7	63	9	pretreated	pretreate	VERB
cord-011435-x73foqu7	63	10	with	with	ADP
cord-011435-x73foqu7	63	11	the	the	DET
cord-011435-x73foqu7	63	12	drugs	drug	NOUN
cord-011435-x73foqu7	63	13	(	(	PUNCT
cord-011435-x73foqu7	63	14	e.g.	e.g.	ADV
cord-011435-x73foqu7	63	15	,	,	PUNCT
cord-011435-x73foqu7	63	16	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	63	17	at	at	ADP
cord-011435-x73foqu7	63	18	5	5	NUM
cord-011435-x73foqu7	63	19	µm	µm	NOUN
cord-011435-x73foqu7	63	20	,	,	PUNCT
cord-011435-x73foqu7	63	21	and	and	CCONJ
cord-011435-x73foqu7	63	22	pyrvinium	pyrvinium	ADJ
cord-011435-x73foqu7	63	23	pamoate	pamoate	NOUN
cord-011435-x73foqu7	63	24	at	at	ADP
cord-011435-x73foqu7	63	25	1	1	NUM
cord-011435-x73foqu7	63	26	µm	µm	NOUN
cord-011435-x73foqu7	63	27	or	or	CCONJ
cord-011435-x73foqu7	63	28	as	as	SCONJ
cord-011435-x73foqu7	63	29	indicated	indicate	VERB
cord-011435-x73foqu7	63	30	in	in	ADP
cord-011435-x73foqu7	63	31	the	the	DET
cord-011435-x73foqu7	63	32	figures	figure	NOUN
cord-011435-x73foqu7	63	33	)	)	PUNCT
cord-011435-x73foqu7	63	34	for	for	ADP
cord-011435-x73foqu7	63	35	1	1	NUM
cord-011435-x73foqu7	63	36	h	h	NOUN
cord-011435-x73foqu7	63	37	before	before	ADP
cord-011435-x73foqu7	63	38	ripa	ripa	ADJ
cord-011435-x73foqu7	63	39	stimulation	stimulation	NOUN
cord-011435-x73foqu7	63	40	(	(	PUNCT
cord-011435-x73foqu7	63	41	polyi	polyi	NOUN
cord-011435-x73foqu7	63	42	:	:	PUNCT
cord-011435-x73foqu7	63	43	c	c	PROPN
cord-011435-x73foqu7	63	44	transfection	transfection	NOUN
cord-011435-x73foqu7	63	45	)	)	PUNCT
cord-011435-x73foqu7	63	46	.	.	PUNCT
cord-011435-x73foqu7	64	1	dmso	dmso	PROPN
cord-011435-x73foqu7	64	2	was	be	AUX
cord-011435-x73foqu7	64	3	used	use	VERB
cord-011435-x73foqu7	64	4	as	as	ADP
cord-011435-x73foqu7	64	5	a	a	DET
cord-011435-x73foqu7	64	6	vehicle	vehicle	NOUN
cord-011435-x73foqu7	64	7	control	control	NOUN
cord-011435-x73foqu7	64	8	for	for	ADP
cord-011435-x73foqu7	64	9	these	these	DET
cord-011435-x73foqu7	64	10	drugs	drug	NOUN
cord-011435-x73foqu7	64	11	.	.	PUNCT
cord-011435-x73foqu7	65	1	ht1080	ht1080	PROPN
cord-011435-x73foqu7	65	2	cells	cell	NOUN
cord-011435-x73foqu7	65	3	were	be	AUX
cord-011435-x73foqu7	65	4	transfected	transfecte	VERB
cord-011435-x73foqu7	65	5	with	with	ADP
cord-011435-x73foqu7	65	6	either	either	CCONJ
cord-011435-x73foqu7	65	7	control	control	NOUN
cord-011435-x73foqu7	65	8	(	(	PUNCT
cord-011435-x73foqu7	65	9	sc-418922	sc-418922	PROPN
cord-011435-x73foqu7	65	10	)	)	PUNCT
cord-011435-x73foqu7	65	11	or	or	CCONJ
cord-011435-x73foqu7	65	12	irf3	irf3	PROPN
cord-011435-x73foqu7	65	13	-	-	PUNCT
cord-011435-x73foqu7	65	14	specific	specific	ADJ
cord-011435-x73foqu7	65	15	(	(	PUNCT
cord-011435-x73foqu7	65	16	sc-417171	sc-417171	ADJ
cord-011435-x73foqu7	65	17	)	)	PUNCT
cord-011435-x73foqu7	65	18	crispr	crispr	NOUN
cord-011435-x73foqu7	65	19	/	/	SYM
cord-011435-x73foqu7	65	20	cas9	cas9	NOUN
cord-011435-x73foqu7	65	21	plasmids	plasmid	NOUN
cord-011435-x73foqu7	65	22	(	(	PUNCT
cord-011435-x73foqu7	65	23	santa	santa	PROPN
cord-011435-x73foqu7	65	24	cruz	cruz	NOUN
cord-011435-x73foqu7	65	25	)	)	PUNCT
cord-011435-x73foqu7	65	26	using	use	VERB
cord-011435-x73foqu7	65	27	lipofectamine	lipofectamine	PROPN
cord-011435-x73foqu7	65	28	2000	2000	NUM
cord-011435-x73foqu7	65	29	(	(	PUNCT
cord-011435-x73foqu7	65	30	thermo	thermo	PROPN
cord-011435-x73foqu7	65	31	fisher	fisher	PROPN
cord-011435-x73foqu7	65	32	scientific	scientific	PROPN
cord-011435-x73foqu7	65	33	)	)	PUNCT
cord-011435-x73foqu7	65	34	.	.	PUNCT
cord-011435-x73foqu7	66	1	transfected	transfecte	VERB
cord-011435-x73foqu7	66	2	cells	cell	NOUN
cord-011435-x73foqu7	66	3	were	be	AUX
cord-011435-x73foqu7	66	4	sorted	sort	VERB
cord-011435-x73foqu7	66	5	for	for	ADP
cord-011435-x73foqu7	66	6	high	high	ADJ
cord-011435-x73foqu7	66	7	gfp	gfp	NOUN
cord-011435-x73foqu7	66	8	-	-	PUNCT
cord-011435-x73foqu7	66	9	expressers	expresser	NOUN
cord-011435-x73foqu7	66	10	using	use	VERB
cord-011435-x73foqu7	66	11	flow	flow	NOUN
cord-011435-x73foqu7	66	12	cytometry	cytometry	NOUN
cord-011435-x73foqu7	66	13	,	,	PUNCT
cord-011435-x73foqu7	66	14	and	and	CCONJ
cord-011435-x73foqu7	66	15	the	the	DET
cord-011435-x73foqu7	66	16	gfp	gfp	NOUN
cord-011435-x73foqu7	66	17	-	-	PUNCT
cord-011435-x73foqu7	66	18	expressing	express	VERB
cord-011435-x73foqu7	66	19	cells	cell	NOUN
cord-011435-x73foqu7	66	20	were	be	AUX
cord-011435-x73foqu7	66	21	expanded	expand	VERB
cord-011435-x73foqu7	66	22	to	to	PART
cord-011435-x73foqu7	66	23	isolate	isolate	VERB
cord-011435-x73foqu7	66	24	individual	individual	ADJ
cord-011435-x73foqu7	66	25	clones	clone	NOUN
cord-011435-x73foqu7	66	26	.	.	PUNCT
cord-011435-x73foqu7	67	1	these	these	DET
cord-011435-x73foqu7	67	2	clones	clone	NOUN
cord-011435-x73foqu7	67	3	were	be	AUX
cord-011435-x73foqu7	67	4	screened	screen	VERB
cord-011435-x73foqu7	67	5	for	for	ADP
cord-011435-x73foqu7	67	6	irf3	irf3	PROPN
cord-011435-x73foqu7	67	7	protein	protein	NOUN
cord-011435-x73foqu7	67	8	levels	level	NOUN
cord-011435-x73foqu7	67	9	by	by	ADP
cord-011435-x73foqu7	67	10	immunoblot	immunoblot	NOUN
cord-011435-x73foqu7	67	11	,	,	PUNCT
cord-011435-x73foqu7	67	12	and	and	CCONJ
cord-011435-x73foqu7	67	13	the	the	DET
cord-011435-x73foqu7	67	14	clones	clone	NOUN
cord-011435-x73foqu7	67	15	with	with	ADP
cord-011435-x73foqu7	67	16	no	no	DET
cord-011435-x73foqu7	67	17	irf3	irf3	PROPN
cord-011435-x73foqu7	67	18	protein	protein	NOUN
cord-011435-x73foqu7	67	19	expression	expression	NOUN
cord-011435-x73foqu7	67	20	were	be	AUX
cord-011435-x73foqu7	67	21	expanded	expand	VERB
cord-011435-x73foqu7	67	22	and	and	CCONJ
cord-011435-x73foqu7	67	23	further	far	ADV
cord-011435-x73foqu7	67	24	validated	validate	VERB
cord-011435-x73foqu7	67	25	using	use	VERB
cord-011435-x73foqu7	67	26	functional	functional	ADJ
cord-011435-x73foqu7	67	27	assay	assay	NOUN
cord-011435-x73foqu7	67	28	to	to	PART
cord-011435-x73foqu7	67	29	ensure	ensure	VERB
cord-011435-x73foqu7	67	30	the	the	DET
cord-011435-x73foqu7	67	31	absence	absence	NOUN
cord-011435-x73foqu7	67	32	of	of	ADP
cord-011435-x73foqu7	67	33	irf3	irf3	PROPN
cord-011435-x73foqu7	67	34	-	-	PUNCT
cord-011435-x73foqu7	67	35	dependent	dependent	ADJ
cord-011435-x73foqu7	67	36	ifit3	ifit3	PROPN
cord-011435-x73foqu7	67	37	induction	induction	NOUN
cord-011435-x73foqu7	67	38	upon	upon	SCONJ
cord-011435-x73foqu7	67	39	rlr	rlr	NOUN
cord-011435-x73foqu7	67	40	stimulation	stimulation	NOUN
cord-011435-x73foqu7	67	41	(	(	PUNCT
cord-011435-x73foqu7	67	42	figure	figure	NOUN
cord-011435-x73foqu7	67	43	s2	s2	PROPN
cord-011435-x73foqu7	67	44	)	)	PUNCT
cord-011435-x73foqu7	67	45	.	.	PUNCT
cord-011435-x73foqu7	68	1	vesicular	vesicular	ADJ
cord-011435-x73foqu7	68	2	stomatitis	stomatitis	PROPN
cord-011435-x73foqu7	68	3	virus	virus	PROPN
cord-011435-x73foqu7	68	4	(	(	PUNCT
cord-011435-x73foqu7	68	5	vsv	vsv	PROPN
cord-011435-x73foqu7	68	6	)	)	PUNCT
cord-011435-x73foqu7	68	7	indiana	indiana	PROPN
cord-011435-x73foqu7	68	8	strain	strain	NOUN
cord-011435-x73foqu7	68	9	expressing	express	VERB
cord-011435-x73foqu7	68	10	green	green	ADJ
cord-011435-x73foqu7	68	11	fluorescent	fluorescent	NOUN
cord-011435-x73foqu7	68	12	protein	protein	NOUN
cord-011435-x73foqu7	68	13	(	(	PUNCT
cord-011435-x73foqu7	68	14	gfp	gfp	NOUN
cord-011435-x73foqu7	68	15	)	)	PUNCT
cord-011435-x73foqu7	68	16	,	,	PUNCT
cord-011435-x73foqu7	68	17	sendai	sendai	PROPN
cord-011435-x73foqu7	68	18	virus	virus	PROPN
cord-011435-x73foqu7	68	19	(	(	PUNCT
cord-011435-x73foqu7	68	20	sev	sev	X
cord-011435-x73foqu7	68	21	)	)	PUNCT
cord-011435-x73foqu7	68	22	cantell	cantell	NOUN
cord-011435-x73foqu7	68	23	strain	strain	NOUN
cord-011435-x73foqu7	68	24	(	(	PUNCT
cord-011435-x73foqu7	68	25	charles	charle	NOUN
cord-011435-x73foqu7	68	26	river	river	NOUN
cord-011435-x73foqu7	68	27	laboratories	laboratory	NOUN
cord-011435-x73foqu7	68	28	,	,	PUNCT
cord-011435-x73foqu7	68	29	garfield	garfield	PROPN
cord-011435-x73foqu7	68	30	heights	height	NOUN
cord-011435-x73foqu7	68	31	,	,	PUNCT
cord-011435-x73foqu7	68	32	oh	oh	PROPN
cord-011435-x73foqu7	68	33	,	,	PUNCT
cord-011435-x73foqu7	68	34	usa	usa	PROPN
cord-011435-x73foqu7	68	35	)	)	PUNCT
cord-011435-x73foqu7	68	36	,	,	PUNCT
cord-011435-x73foqu7	68	37	herpes	herpe	NOUN
cord-011435-x73foqu7	68	38	simplex	simplex	ADJ
cord-011435-x73foqu7	68	39	virus	virus	NOUN
cord-011435-x73foqu7	68	40	1	1	NUM
cord-011435-x73foqu7	68	41	(	(	PUNCT
cord-011435-x73foqu7	68	42	hsv-1	hsv-1	X
cord-011435-x73foqu7	68	43	)	)	PUNCT
cord-011435-x73foqu7	68	44	kos	kos	PROPN
cord-011435-x73foqu7	68	45	and	and	CCONJ
cord-011435-x73foqu7	68	46	f	f	PROPN
cord-011435-x73foqu7	68	47	strains	strain	NOUN
cord-011435-x73foqu7	68	48	,	,	PUNCT
cord-011435-x73foqu7	68	49	langat	langat	NOUN
cord-011435-x73foqu7	68	50	virus	virus	NOUN
cord-011435-x73foqu7	68	51	(	(	PUNCT
cord-011435-x73foqu7	68	52	lgtv	lgtv	PROPN
cord-011435-x73foqu7	68	53	)	)	PUNCT
cord-011435-x73foqu7	68	54	,	,	PUNCT
cord-011435-x73foqu7	68	55	kunjin	kunjin	PROPN
cord-011435-x73foqu7	68	56	virus	virus	PROPN
cord-011435-x73foqu7	68	57	(	(	PUNCT
cord-011435-x73foqu7	68	58	kunv	kunv	PROPN
cord-011435-x73foqu7	68	59	)	)	PUNCT
cord-011435-x73foqu7	68	60	,	,	PUNCT
cord-011435-x73foqu7	68	61	and	and	CCONJ
cord-011435-x73foqu7	68	62	the	the	DET
cord-011435-x73foqu7	68	63	infection	infection	NOUN
cord-011435-x73foqu7	68	64	procedures	procedure	NOUN
cord-011435-x73foqu7	68	65	have	have	AUX
cord-011435-x73foqu7	68	66	been	be	AUX
cord-011435-x73foqu7	68	67	described	describe	VERB
cord-011435-x73foqu7	68	68	previously	previously	ADV
cord-011435-x73foqu7	68	69	[	[	PUNCT
cord-011435-x73foqu7	68	70	13	13	NUM
cord-011435-x73foqu7	68	71	,	,	PUNCT
cord-011435-x73foqu7	68	72	20	20	NUM
cord-011435-x73foqu7	68	73	,	,	PUNCT
cord-011435-x73foqu7	68	74	23	23	NUM
cord-011435-x73foqu7	68	75	]	]	PUNCT
cord-011435-x73foqu7	68	76	.	.	PUNCT
cord-011435-x73foqu7	69	1	briefly	briefly	ADV
cord-011435-x73foqu7	69	2	,	,	PUNCT
cord-011435-x73foqu7	69	3	the	the	DET
cord-011435-x73foqu7	69	4	cells	cell	NOUN
cord-011435-x73foqu7	69	5	were	be	AUX
cord-011435-x73foqu7	69	6	infected	infect	VERB
cord-011435-x73foqu7	69	7	with	with	ADP
cord-011435-x73foqu7	69	8	the	the	DET
cord-011435-x73foqu7	69	9	viruses	virus	NOUN
cord-011435-x73foqu7	69	10	[	[	X
cord-011435-x73foqu7	69	11	at	at	ADP
cord-011435-x73foqu7	69	12	a	a	DET
cord-011435-x73foqu7	69	13	multiplicity	multiplicity	NOUN
cord-011435-x73foqu7	69	14	of	of	ADP
cord-011435-x73foqu7	69	15	infection	infection	NOUN
cord-011435-x73foqu7	69	16	(	(	PUNCT
cord-011435-x73foqu7	69	17	moi	moi	X
cord-011435-x73foqu7	69	18	)	)	PUNCT
cord-011435-x73foqu7	69	19	of	of	ADP
cord-011435-x73foqu7	69	20	1	1	NUM
cord-011435-x73foqu7	69	21	]	]	PUNCT
cord-011435-x73foqu7	69	22	in	in	ADP
cord-011435-x73foqu7	69	23	serum	serum	NOUN
cord-011435-x73foqu7	69	24	-	-	PUNCT
cord-011435-x73foqu7	69	25	free	free	ADJ
cord-011435-x73foqu7	69	26	dmem	dmem	PROPN
cord-011435-x73foqu7	69	27	for	for	ADP
cord-011435-x73foqu7	69	28	2	2	NUM
cord-011435-x73foqu7	69	29	h	h	NUM
cord-011435-x73foqu7	69	30	,	,	PUNCT
cord-011435-x73foqu7	69	31	after	after	ADP
cord-011435-x73foqu7	69	32	which	which	PRON
cord-011435-x73foqu7	69	33	the	the	DET
cord-011435-x73foqu7	69	34	cells	cell	NOUN
cord-011435-x73foqu7	69	35	were	be	AUX
cord-011435-x73foqu7	69	36	washed	wash	VERB
cord-011435-x73foqu7	69	37	and	and	CCONJ
cord-011435-x73foqu7	69	38	replaced	replace	VERB
cord-011435-x73foqu7	69	39	with	with	ADP
cord-011435-x73foqu7	69	40	normal	normal	ADJ
cord-011435-x73foqu7	69	41	growth	growth	NOUN
cord-011435-x73foqu7	69	42	medium	medium	NOUN
cord-011435-x73foqu7	69	43	.	.	PUNCT
cord-011435-x73foqu7	70	1	the	the	DET
cord-011435-x73foqu7	70	2	virus	virus	NOUN
cord-011435-x73foqu7	70	3	-	-	PUNCT
cord-011435-x73foqu7	70	4	infected	infect	VERB
cord-011435-x73foqu7	70	5	cells	cell	NOUN
cord-011435-x73foqu7	70	6	were	be	AUX
cord-011435-x73foqu7	70	7	analyzed	analyze	VERB
cord-011435-x73foqu7	70	8	at	at	ADP
cord-011435-x73foqu7	70	9	the	the	DET
cord-011435-x73foqu7	70	10	indicated	indicate	VERB
cord-011435-x73foqu7	70	11	time	time	NOUN
cord-011435-x73foqu7	70	12	for	for	ADP
cord-011435-x73foqu7	70	13	viral	viral	ADJ
cord-011435-x73foqu7	70	14	protein	protein	NOUN
cord-011435-x73foqu7	70	15	expression	expression	NOUN
cord-011435-x73foqu7	70	16	or	or	CCONJ
cord-011435-x73foqu7	70	17	as	as	SCONJ
cord-011435-x73foqu7	70	18	described	describe	VERB
cord-011435-x73foqu7	70	19	in	in	ADP
cord-011435-x73foqu7	70	20	figure	figure	NOUN
cord-011435-x73foqu7	70	21	legends	legend	NOUN
cord-011435-x73foqu7	70	22	.	.	PUNCT
cord-011435-x73foqu7	71	1	for	for	ADP
cord-011435-x73foqu7	71	2	quantification	quantification	NOUN
cord-011435-x73foqu7	71	3	of	of	ADP
cord-011435-x73foqu7	71	4	infectious	infectious	ADJ
cord-011435-x73foqu7	71	5	virus	virus	NOUN
cord-011435-x73foqu7	71	6	particles	particle	NOUN
cord-011435-x73foqu7	71	7	in	in	ADP
cord-011435-x73foqu7	71	8	the	the	DET
cord-011435-x73foqu7	71	9	culture	culture	NOUN
cord-011435-x73foqu7	71	10	medium	medium	NOUN
cord-011435-x73foqu7	71	11	,	,	PUNCT
cord-011435-x73foqu7	71	12	plaque	plaque	NOUN
cord-011435-x73foqu7	71	13	assays	assay	NOUN
cord-011435-x73foqu7	71	14	were	be	AUX
cord-011435-x73foqu7	71	15	performed	perform	VERB
cord-011435-x73foqu7	71	16	for	for	ADP
cord-011435-x73foqu7	71	17	vsv	vsv	NOUN
cord-011435-x73foqu7	71	18	in	in	ADP
cord-011435-x73foqu7	71	19	10	10	NUM
cord-011435-x73foqu7	71	20	-	-	ADJ
cord-011435-x73foqu7	71	21	fold	fold	ADJ
cord-011435-x73foqu7	71	22	serial	serial	ADJ
cord-011435-x73foqu7	71	23	dilution	dilution	NOUN
cord-011435-x73foqu7	71	24	on	on	ADP
cord-011435-x73foqu7	71	25	vero	vero	NOUN
cord-011435-x73foqu7	71	26	cells	cell	NOUN
cord-011435-x73foqu7	71	27	[	[	X
cord-011435-x73foqu7	71	28	24	24	NUM
cord-011435-x73foqu7	71	29	]	]	PUNCT
cord-011435-x73foqu7	71	30	.	.	PUNCT
cord-011435-x73foqu7	72	1	hsv-1	hsv-1	PUNCT
cord-011435-x73foqu7	72	2	titer	titer	NOUN
cord-011435-x73foqu7	72	3	was	be	AUX
cord-011435-x73foqu7	72	4	measured	measure	VERB
cord-011435-x73foqu7	72	5	by	by	ADP
cord-011435-x73foqu7	72	6	tcid50	tcid50	NOUN
cord-011435-x73foqu7	72	7	using	use	VERB
cord-011435-x73foqu7	72	8	10	10	NUM
cord-011435-x73foqu7	72	9	-	-	ADJ
cord-011435-x73foqu7	72	10	fold	fold	ADJ
cord-011435-x73foqu7	72	11	serial	serial	ADJ
cord-011435-x73foqu7	72	12	dilution	dilution	NOUN
cord-011435-x73foqu7	72	13	of	of	ADP
cord-011435-x73foqu7	72	14	the	the	DET
cord-011435-x73foqu7	72	15	culture	culture	NOUN
cord-011435-x73foqu7	72	16	media	medium	NOUN
cord-011435-x73foqu7	72	17	on	on	ADP
cord-011435-x73foqu7	72	18	vero	vero	NOUN
cord-011435-x73foqu7	72	19	cells	cell	NOUN
cord-011435-x73foqu7	72	20	[	[	X
cord-011435-x73foqu7	72	21	25	25	NUM
cord-011435-x73foqu7	72	22	]	]	PUNCT
cord-011435-x73foqu7	72	23	.	.	PUNCT
cord-011435-x73foqu7	73	1	plaque	plaque	NOUN
cord-011435-x73foqu7	73	2	assays	assay	NOUN
cord-011435-x73foqu7	73	3	were	be	AUX
cord-011435-x73foqu7	73	4	performed	perform	VERB
cord-011435-x73foqu7	73	5	for	for	ADP
cord-011435-x73foqu7	73	6	lgtv	lgtv	PROPN
cord-011435-x73foqu7	73	7	and	and	CCONJ
cord-011435-x73foqu7	73	8	kunv	kunv	PROPN
cord-011435-x73foqu7	73	9	using	use	VERB
cord-011435-x73foqu7	73	10	previously	previously	ADV
cord-011435-x73foqu7	73	11	described	describe	VERB
cord-011435-x73foqu7	73	12	procedures	procedure	NOUN
cord-011435-x73foqu7	73	13	[	[	X
cord-011435-x73foqu7	73	14	23	23	NUM
cord-011435-x73foqu7	73	15	]	]	PUNCT
cord-011435-x73foqu7	73	16	.	.	PUNCT
cord-011435-x73foqu7	74	1	to	to	PART
cord-011435-x73foqu7	74	2	determine	determine	VERB
cord-011435-x73foqu7	74	3	the	the	DET
cord-011435-x73foqu7	74	4	effects	effect	NOUN
cord-011435-x73foqu7	74	5	of	of	ADP
cord-011435-x73foqu7	74	6	the	the	DET
cord-011435-x73foqu7	74	7	drugs	drug	NOUN
cord-011435-x73foqu7	74	8	on	on	ADP
cord-011435-x73foqu7	74	9	viral	viral	ADJ
cord-011435-x73foqu7	74	10	replication	replication	NOUN
cord-011435-x73foqu7	74	11	,	,	PUNCT
cord-011435-x73foqu7	74	12	the	the	DET
cord-011435-x73foqu7	74	13	cells	cell	NOUN
cord-011435-x73foqu7	74	14	were	be	AUX
cord-011435-x73foqu7	74	15	pre	pre	VERB
cord-011435-x73foqu7	74	16	-	-	VERB
cord-011435-x73foqu7	74	17	treated	treat	VERB
cord-011435-x73foqu7	74	18	with	with	ADP
cord-011435-x73foqu7	74	19	dmem	dmem	PROPN
cord-011435-x73foqu7	74	20	containing	contain	VERB
cord-011435-x73foqu7	74	21	dmso	dmso	PROPN
cord-011435-x73foqu7	74	22	(	(	PUNCT
cord-011435-x73foqu7	74	23	vehicle	vehicle	NOUN
cord-011435-x73foqu7	74	24	)	)	PUNCT
cord-011435-x73foqu7	74	25	or	or	CCONJ
cord-011435-x73foqu7	74	26	individual	individual	ADJ
cord-011435-x73foqu7	74	27	drugs	drug	NOUN
cord-011435-x73foqu7	74	28	at	at	ADP
cord-011435-x73foqu7	74	29	the	the	DET
cord-011435-x73foqu7	74	30	indicated	indicate	VERB
cord-011435-x73foqu7	74	31	concentrations	concentration	NOUN
cord-011435-x73foqu7	74	32	for	for	ADP
cord-011435-x73foqu7	74	33	2	2	NUM
cord-011435-x73foqu7	74	34	h	h	NOUN
cord-011435-x73foqu7	74	35	before	before	ADP
cord-011435-x73foqu7	74	36	virus	virus	NOUN
cord-011435-x73foqu7	74	37	infection	infection	NOUN
cord-011435-x73foqu7	74	38	,	,	PUNCT
cord-011435-x73foqu7	74	39	removed	remove	VERB
cord-011435-x73foqu7	74	40	during	during	ADP
cord-011435-x73foqu7	74	41	the	the	DET
cord-011435-x73foqu7	74	42	virus	virus	NOUN
cord-011435-x73foqu7	74	43	adsorption	adsorption	NOUN
cord-011435-x73foqu7	74	44	,	,	PUNCT
cord-011435-x73foqu7	74	45	and	and	CCONJ
cord-011435-x73foqu7	74	46	reintroduced	reintroduce	VERB
cord-011435-x73foqu7	74	47	post	post	NOUN
cord-011435-x73foqu7	74	48	adsorption	adsorption	NOUN
cord-011435-x73foqu7	74	49	.	.	PUNCT
cord-011435-x73foqu7	75	1	equal	equal	ADJ
cord-011435-x73foqu7	75	2	protein	protein	NOUN
cord-011435-x73foqu7	75	3	extracts	extract	NOUN
cord-011435-x73foqu7	75	4	from	from	ADP
cord-011435-x73foqu7	75	5	the	the	DET
cord-011435-x73foqu7	75	6	gfp.vsv	gfp.vsv	PROPN
cord-011435-x73foqu7	75	7	-	-	PUNCT
cord-011435-x73foqu7	75	8	infected	infect	VERB
cord-011435-x73foqu7	75	9	cells	cell	NOUN
cord-011435-x73foqu7	75	10	were	be	AUX
cord-011435-x73foqu7	75	11	analyzed	analyze	VERB
cord-011435-x73foqu7	75	12	for	for	ADP
cord-011435-x73foqu7	75	13	gfp	gfp	PROPN
cord-011435-x73foqu7	75	14	fluorescence	fluorescence	PROPN
cord-011435-x73foqu7	75	15	using	use	VERB
cord-011435-x73foqu7	75	16	a	a	DET
cord-011435-x73foqu7	75	17	plate	plate	NOUN
cord-011435-x73foqu7	75	18	reader	reader	NOUN
cord-011435-x73foqu7	75	19	.	.	PUNCT
cord-011435-x73foqu7	76	1	gfp	gfp	PROPN
cord-011435-x73foqu7	76	2	fluorescence	fluorescence	PROPN
cord-011435-x73foqu7	76	3	of	of	ADP
cord-011435-x73foqu7	76	4	vehicle	vehicle	NOUN
cord-011435-x73foqu7	76	5	-	-	PUNCT
cord-011435-x73foqu7	76	6	treated	treat	VERB
cord-011435-x73foqu7	76	7	vsv	vsv	PROPN
cord-011435-x73foqu7	76	8	-	-	PUNCT
cord-011435-x73foqu7	76	9	infected	infect	VERB
cord-011435-x73foqu7	76	10	cells	cell	NOUN
cord-011435-x73foqu7	76	11	was	be	AUX
cord-011435-x73foqu7	76	12	set	set	VERB
cord-011435-x73foqu7	76	13	arbitrarily	arbitrarily	ADV
cord-011435-x73foqu7	76	14	at	at	ADP
cord-011435-x73foqu7	76	15	100	100	NUM
cord-011435-x73foqu7	76	16	and	and	CCONJ
cord-011435-x73foqu7	76	17	all	all	DET
cord-011435-x73foqu7	76	18	other	other	ADJ
cord-011435-x73foqu7	76	19	values	value	NOUN
cord-011435-x73foqu7	76	20	were	be	AUX
cord-011435-x73foqu7	76	21	normalized	normalize	VERB
cord-011435-x73foqu7	76	22	to	to	ADP
cord-011435-x73foqu7	76	23	this	this	PRON
cord-011435-x73foqu7	76	24	.	.	PUNCT
cord-011435-x73foqu7	77	1	immunoblot	immunoblot	NOUN
cord-011435-x73foqu7	77	2	analyses	analysis	NOUN
cord-011435-x73foqu7	77	3	were	be	AUX
cord-011435-x73foqu7	77	4	performed	perform	VERB
cord-011435-x73foqu7	77	5	using	use	VERB
cord-011435-x73foqu7	77	6	previously	previously	ADV
cord-011435-x73foqu7	77	7	described	describe	VERB
cord-011435-x73foqu7	77	8	procedures	procedure	NOUN
cord-011435-x73foqu7	77	9	[	[	PUNCT
cord-011435-x73foqu7	77	10	7	7	NUM
cord-011435-x73foqu7	77	11	,	,	PUNCT
cord-011435-x73foqu7	77	12	9	9	NUM
cord-011435-x73foqu7	77	13	]	]	PUNCT
cord-011435-x73foqu7	77	14	.	.	PUNCT
cord-011435-x73foqu7	78	1	briefly	briefly	ADV
cord-011435-x73foqu7	78	2	,	,	PUNCT
cord-011435-x73foqu7	78	3	the	the	DET
cord-011435-x73foqu7	78	4	cells	cell	NOUN
cord-011435-x73foqu7	78	5	were	be	AUX
cord-011435-x73foqu7	78	6	lysed	lyse	VERB
cord-011435-x73foqu7	78	7	in	in	ADP
cord-011435-x73foqu7	78	8	50	50	NUM
cord-011435-x73foqu7	78	9	mm	mm	PROPN
cord-011435-x73foqu7	78	10	tris	tris	NOUN
cord-011435-x73foqu7	78	11	buffer	buffer	NOUN
cord-011435-x73foqu7	78	12	,	,	PUNCT
cord-011435-x73foqu7	78	13	ph	ph	NOUN
cord-011435-x73foqu7	78	14	7.4	7.4	NUM
cord-011435-x73foqu7	78	15	,	,	PUNCT
cord-011435-x73foqu7	78	16	containing	contain	VERB
cord-011435-x73foqu7	78	17	150	150	NUM
cord-011435-x73foqu7	78	18	mm	mm	NOUN
cord-011435-x73foqu7	78	19	of	of	ADP
cord-011435-x73foqu7	78	20	nacl	nacl	PROPN
cord-011435-x73foqu7	78	21	,	,	PUNCT
cord-011435-x73foqu7	78	22	0.1	0.1	NUM
cord-011435-x73foqu7	78	23	%	%	NOUN
cord-011435-x73foqu7	78	24	triton	triton	PROPN
cord-011435-x73foqu7	78	25	x-100	x-100	PROPN
cord-011435-x73foqu7	78	26	,	,	PUNCT
cord-011435-x73foqu7	78	27	1	1	NUM
cord-011435-x73foqu7	78	28	mm	mm	NOUN
cord-011435-x73foqu7	78	29	sodium	sodium	NOUN
cord-011435-x73foqu7	78	30	orthovanadate	orthovanadate	NOUN
cord-011435-x73foqu7	78	31	,	,	PUNCT
cord-011435-x73foqu7	78	32	10	10	NUM
cord-011435-x73foqu7	78	33	mm	mm	NOUN
cord-011435-x73foqu7	78	34	of	of	ADP
cord-011435-x73foqu7	78	35	sodium	sodium	NOUN
cord-011435-x73foqu7	78	36	fluoride	fluoride	NOUN
cord-011435-x73foqu7	78	37	,	,	PUNCT
cord-011435-x73foqu7	78	38	10	10	NUM
cord-011435-x73foqu7	78	39	mm	mm	NOUN
cord-011435-x73foqu7	78	40	of	of	ADP
cord-011435-x73foqu7	78	41	β	β	NOUN
cord-011435-x73foqu7	78	42	-	-	NOUN
cord-011435-x73foqu7	78	43	glycerophosphate	glycerophosphate	NOUN
cord-011435-x73foqu7	78	44	,	,	PUNCT
cord-011435-x73foqu7	78	45	5	5	NUM
cord-011435-x73foqu7	78	46	mm	mm	NOUN
cord-011435-x73foqu7	78	47	sodium	sodium	NOUN
cord-011435-x73foqu7	78	48	pyrophosphate	pyrophosphate	NOUN
cord-011435-x73foqu7	78	49	,	,	PUNCT
cord-011435-x73foqu7	78	50	protease	protease	NOUN
cord-011435-x73foqu7	78	51	and	and	CCONJ
cord-011435-x73foqu7	78	52	phosphatase	phosphatase	NOUN
cord-011435-x73foqu7	78	53	inhibitors	inhibitor	NOUN
cord-011435-x73foqu7	78	54	(	(	PUNCT
cord-011435-x73foqu7	78	55	roche	roche	NOUN
cord-011435-x73foqu7	78	56	)	)	PUNCT
cord-011435-x73foqu7	78	57	.	.	PUNCT
cord-011435-x73foqu7	79	1	total	total	ADJ
cord-011435-x73foqu7	79	2	protein	protein	NOUN
cord-011435-x73foqu7	79	3	extracts	extract	NOUN
cord-011435-x73foqu7	79	4	were	be	AUX
cord-011435-x73foqu7	79	5	analyzed	analyze	VERB
cord-011435-x73foqu7	79	6	by	by	ADP
cord-011435-x73foqu7	79	7	sds	sds	NOUN
cord-011435-x73foqu7	79	8	-	-	PUNCT
cord-011435-x73foqu7	79	9	page	page	NOUN
cord-011435-x73foqu7	79	10	followed	follow	VERB
cord-011435-x73foqu7	79	11	by	by	ADP
cord-011435-x73foqu7	79	12	immunoblot	immunoblot	NOUN
cord-011435-x73foqu7	79	13	.	.	PUNCT
cord-011435-x73foqu7	80	1	for	for	ADP
cord-011435-x73foqu7	80	2	analyzing	analyze	VERB
cord-011435-x73foqu7	80	3	the	the	DET
cord-011435-x73foqu7	80	4	ubiquitination	ubiquitination	NOUN
cord-011435-x73foqu7	80	5	of	of	ADP
cord-011435-x73foqu7	80	6	irf3	irf3	PROPN
cord-011435-x73foqu7	80	7	,	,	PUNCT
cord-011435-x73foqu7	80	8	a	a	DET
cord-011435-x73foqu7	80	9	previously	previously	ADV
cord-011435-x73foqu7	80	10	described	describe	VERB
cord-011435-x73foqu7	80	11	procedure	procedure	NOUN
cord-011435-x73foqu7	80	12	was	be	AUX
cord-011435-x73foqu7	80	13	followed	follow	VERB
cord-011435-x73foqu7	80	14	[	[	X
cord-011435-x73foqu7	80	15	7	7	NUM
cord-011435-x73foqu7	80	16	]	]	PUNCT
cord-011435-x73foqu7	80	17	.	.	PUNCT
cord-011435-x73foqu7	81	1	the	the	DET
cord-011435-x73foqu7	81	2	immunoblots	immunoblot	NOUN
cord-011435-x73foqu7	81	3	were	be	AUX
cord-011435-x73foqu7	81	4	quantified	quantify	VERB
cord-011435-x73foqu7	81	5	by	by	ADP
cord-011435-x73foqu7	81	6	image	image	PROPN
cord-011435-x73foqu7	81	7	j	j	PROPN
cord-011435-x73foqu7	81	8	software	software	PROPN
cord-011435-x73foqu7	81	9	.	.	PUNCT
cord-011435-x73foqu7	82	1	total	total	PROPN
cord-011435-x73foqu7	82	2	rna	rna	PROPN
cord-011435-x73foqu7	82	3	was	be	AUX
cord-011435-x73foqu7	82	4	isolated	isolate	VERB
cord-011435-x73foqu7	82	5	using	use	VERB
cord-011435-x73foqu7	82	6	trizol	trizol	PROPN
cord-011435-x73foqu7	82	7	(	(	PUNCT
cord-011435-x73foqu7	82	8	thermo	thermo	PROPN
cord-011435-x73foqu7	82	9	fisher	fisher	PROPN
cord-011435-x73foqu7	82	10	scientific	scientific	PROPN
cord-011435-x73foqu7	82	11	)	)	PUNCT
cord-011435-x73foqu7	82	12	,	,	PUNCT
cord-011435-x73foqu7	82	13	cdna	cdna	PROPN
cord-011435-x73foqu7	82	14	was	be	AUX
cord-011435-x73foqu7	82	15	prepared	prepare	VERB
cord-011435-x73foqu7	82	16	using	use	VERB
cord-011435-x73foqu7	82	17	improm	improm	PROPN
cord-011435-x73foqu7	82	18	-	-	PUNCT
cord-011435-x73foqu7	82	19	ii	ii	PROPN
cord-011435-x73foqu7	82	20	reverse	reverse	ADJ
cord-011435-x73foqu7	82	21	transcription	transcription	NOUN
cord-011435-x73foqu7	82	22	kit	kit	NOUN
cord-011435-x73foqu7	82	23	(	(	PUNCT
cord-011435-x73foqu7	82	24	promega	promega	PROPN
cord-011435-x73foqu7	82	25	)	)	PUNCT
cord-011435-x73foqu7	82	26	,	,	PUNCT
cord-011435-x73foqu7	82	27	and	and	CCONJ
cord-011435-x73foqu7	82	28	the	the	DET
cord-011435-x73foqu7	82	29	cdna	cdna	PROPN
cord-011435-x73foqu7	82	30	was	be	AUX
cord-011435-x73foqu7	82	31	analyzed	analyze	VERB
cord-011435-x73foqu7	82	32	using	use	VERB
cord-011435-x73foqu7	82	33	radianttm	radianttm	NOUN
cord-011435-x73foqu7	82	34	sybr	sybr	PROPN
cord-011435-x73foqu7	82	35	green	green	ADJ
cord-011435-x73foqu7	82	36	pcr	pcr	PROPN
cord-011435-x73foqu7	82	37	mix	mix	NOUN
cord-011435-x73foqu7	82	38	(	(	PUNCT
cord-011435-x73foqu7	82	39	alkali	alkali	PROPN
cord-011435-x73foqu7	82	40	scientific	scientific	PROPN
cord-011435-x73foqu7	82	41	inc	inc	PROPN
cord-011435-x73foqu7	82	42	.	.	PROPN
cord-011435-x73foqu7	82	43	,	,	PUNCT
cord-011435-x73foqu7	82	44	fort	fort	PROPN
cord-011435-x73foqu7	82	45	lauderdale	lauderdale	PROPN
cord-011435-x73foqu7	82	46	,	,	PUNCT
cord-011435-x73foqu7	82	47	fl	fl	PROPN
cord-011435-x73foqu7	82	48	,	,	PUNCT
cord-011435-x73foqu7	82	49	usa	usa	PROPN
cord-011435-x73foqu7	82	50	)	)	PUNCT
cord-011435-x73foqu7	82	51	in	in	ADP
cord-011435-x73foqu7	82	52	roche	roche	PROPN
cord-011435-x73foqu7	82	53	lightcycler	lightcycler	PROPN
cord-011435-x73foqu7	82	54	96	96	PROPN
cord-011435-x73foqu7	82	55	instrument	instrument	NOUN
cord-011435-x73foqu7	82	56	and	and	CCONJ
cord-011435-x73foqu7	82	57	analyzed	analyze	VERB
cord-011435-x73foqu7	82	58	with	with	ADP
cord-011435-x73foqu7	82	59	the	the	DET
cord-011435-x73foqu7	82	60	lightcycler	lightcycler	PROPN
cord-011435-x73foqu7	82	61	480	480	NUM
cord-011435-x73foqu7	82	62	software	software	NOUN
cord-011435-x73foqu7	82	63	,	,	PUNCT
cord-011435-x73foqu7	82	64	version	version	NOUN
cord-011435-x73foqu7	82	65	1.5	1.5	NUM
cord-011435-x73foqu7	82	66	.	.	PUNCT
cord-011435-x73foqu7	83	1	the	the	DET
cord-011435-x73foqu7	83	2	expression	expression	NOUN
cord-011435-x73foqu7	83	3	levels	level	NOUN
cord-011435-x73foqu7	83	4	of	of	ADP
cord-011435-x73foqu7	83	5	the	the	DET
cord-011435-x73foqu7	83	6	mrnas	mrnas	PROPN
cord-011435-x73foqu7	83	7	were	be	AUX
cord-011435-x73foqu7	83	8	normalized	normalize	VERB
cord-011435-x73foqu7	83	9	to	to	ADP
cord-011435-x73foqu7	83	10	18s	18	NOUN
cord-011435-x73foqu7	83	11	rrna	rrna	PROPN
cord-011435-x73foqu7	83	12	.	.	PUNCT
cord-011435-x73foqu7	84	1	for	for	ADP
cord-011435-x73foqu7	84	2	the	the	DET
cord-011435-x73foqu7	84	3	qrt	qrt	ADJ
cord-011435-x73foqu7	84	4	-	-	PUNCT
cord-011435-x73foqu7	84	5	pcr	pcr	NOUN
cord-011435-x73foqu7	84	6	analyses	analysis	NOUN
cord-011435-x73foqu7	84	7	of	of	ADP
cord-011435-x73foqu7	84	8	the	the	DET
cord-011435-x73foqu7	84	9	respective	respective	ADJ
cord-011435-x73foqu7	84	10	genes	gene	NOUN
cord-011435-x73foqu7	84	11	,	,	PUNCT
cord-011435-x73foqu7	84	12	the	the	DET
cord-011435-x73foqu7	84	13	following	follow	VERB
cord-011435-x73foqu7	84	14	primers	primer	NOUN
cord-011435-x73foqu7	84	15	were	be	AUX
cord-011435-x73foqu7	84	16	used	use	VERB
cord-011435-x73foqu7	84	17	:	:	PUNCT
cord-011435-x73foqu7	84	18	ifit1	ifit1	PROPN
cord-011435-x73foqu7	84	19	-	-	PUNCT
cord-011435-x73foqu7	84	20	fwd	fwd	PROPN
cord-011435-x73foqu7	84	21	:	:	PUNCT
cord-011435-x73foqu7	84	22	tctcagaggagcctggctaag	tctcagaggagcctggctaag	PROPN
cord-011435-x73foqu7	84	23	,	,	PUNCT
cord-011435-x73foqu7	84	24	ifit1	ifit1	PROPN
cord-011435-x73foqu7	84	25	-	-	PUNCT
cord-011435-x73foqu7	84	26	rev	rev	PROPN
cord-011435-x73foqu7	84	27	:	:	PUNCT
cord-011435-x73foqu7	84	28	gtcaccagactcctcacatttgc	gtcaccagactcctcacatttgc	NOUN
cord-011435-x73foqu7	84	29	,	,	PUNCT
cord-011435-x73foqu7	84	30	ifit3	ifit3	NOUN
cord-011435-x73foqu7	84	31	-	-	PUNCT
cord-011435-x73foqu7	84	32	fwd	fwd	ADV
cord-011435-x73foqu7	84	33	:	:	PUNCT
cord-011435-x73foqu7	84	34	gaacatgctgaccaagcaga	gaacatgctgaccaagcaga	PROPN
cord-011435-x73foqu7	84	35	,	,	PUNCT
cord-011435-x73foqu7	84	36	ifit3	ifit3	PROPN
cord-011435-x73foqu7	84	37	-	-	PUNCT
cord-011435-x73foqu7	84	38	rev	rev	PROPN
cord-011435-x73foqu7	84	39	:	:	PUNCT
cord-011435-x73foqu7	84	40	cagttgtgtccacccttcct	cagttgtgtccacccttcct	PROPN
cord-011435-x73foqu7	84	41	,	,	PUNCT
cord-011435-x73foqu7	84	42	ifnb1	ifnb1	NOUN
cord-011435-x73foqu7	84	43	-	-	PUNCT
cord-011435-x73foqu7	84	44	fwd	fwd	PROPN
cord-011435-x73foqu7	84	45	:	:	PUNCT
cord-011435-x73foqu7	84	46	cgccgcattgaccatcta	cgccgcattgaccatcta	PROPN
cord-011435-x73foqu7	84	47	,	,	PUNCT
cord-011435-x73foqu7	84	48	ifnb1	ifnb1	NOUN
cord-011435-x73foqu7	84	49	-	-	PUNCT
cord-011435-x73foqu7	84	50	rev	rev	PROPN
cord-011435-x73foqu7	84	51	:	:	PUNCT
cord-011435-x73foqu7	84	52	gacattagccaggaggttct	gacattagccaggaggttct	PROPN
cord-011435-x73foqu7	84	53	,	,	PUNCT
cord-011435-x73foqu7	84	54	18s	18	NOUN
cord-011435-x73foqu7	84	55	-	-	PUNCT
cord-011435-x73foqu7	84	56	fwd	fwd	NOUN
cord-011435-x73foqu7	84	57	:	:	PUNCT
cord-011435-x73foqu7	84	58	attgacggaagggcaccaccag	attgacggaagggcaccaccag	PROPN
cord-011435-x73foqu7	84	59	,	,	PUNCT
cord-011435-x73foqu7	84	60	18s	18	NOUN
cord-011435-x73foqu7	84	61	-	-	PUNCT
cord-011435-x73foqu7	84	62	rev	rev	PROPN
cord-011435-x73foqu7	84	63	:	:	PUNCT
cord-011435-x73foqu7	84	64	caaatcgctccaccaactaagaacg	caaatcgctccaccaactaagaacg	PROPN
cord-011435-x73foqu7	84	65	.	.	PUNCT
cord-011435-x73foqu7	85	1	mda	mda	ADJ
cord-011435-x73foqu7	85	2	-	-	PUNCT
cord-011435-x73foqu7	85	3	mb-453	mb-453	NOUN
cord-011435-x73foqu7	85	4	cells	cell	NOUN
cord-011435-x73foqu7	85	5	were	be	AUX
cord-011435-x73foqu7	85	6	grown	grow	VERB
cord-011435-x73foqu7	85	7	on	on	ADP
cord-011435-x73foqu7	85	8	coverslips	coverslip	NOUN
cord-011435-x73foqu7	85	9	,	,	PUNCT
cord-011435-x73foqu7	85	10	infected	infect	VERB
cord-011435-x73foqu7	85	11	with	with	ADP
cord-011435-x73foqu7	85	12	hsv-1	hsv-1	PUNCT
cord-011435-x73foqu7	85	13	in	in	ADP
cord-011435-x73foqu7	85	14	the	the	DET
cord-011435-x73foqu7	85	15	absence	absence	NOUN
cord-011435-x73foqu7	85	16	or	or	CCONJ
cord-011435-x73foqu7	85	17	the	the	DET
cord-011435-x73foqu7	85	18	presence	presence	NOUN
cord-011435-x73foqu7	85	19	of	of	ADP
cord-011435-x73foqu7	85	20	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	85	21	,	,	PUNCT
cord-011435-x73foqu7	85	22	as	as	SCONJ
cord-011435-x73foqu7	85	23	described	describe	VERB
cord-011435-x73foqu7	85	24	in	in	ADP
cord-011435-x73foqu7	85	25	the	the	DET
cord-011435-x73foqu7	85	26	figure	figure	NOUN
cord-011435-x73foqu7	85	27	legends	legend	NOUN
cord-011435-x73foqu7	85	28	.	.	PUNCT
cord-011435-x73foqu7	86	1	the	the	DET
cord-011435-x73foqu7	86	2	infected	infect	VERB
cord-011435-x73foqu7	86	3	cells	cell	NOUN
cord-011435-x73foqu7	86	4	were	be	AUX
cord-011435-x73foqu7	86	5	fixed	fix	VERB
cord-011435-x73foqu7	86	6	in	in	ADP
cord-011435-x73foqu7	86	7	4	4	NUM
cord-011435-x73foqu7	86	8	%	%	NOUN
cord-011435-x73foqu7	86	9	paraformaldehyde	paraformaldehyde	NOUN
cord-011435-x73foqu7	86	10	(	(	PUNCT
cord-011435-x73foqu7	86	11	electron	electron	NOUN
cord-011435-x73foqu7	86	12	microscopy	microscopy	PROPN
cord-011435-x73foqu7	86	13	sciences	sciences	PROPN
cord-011435-x73foqu7	86	14	,	,	PUNCT
cord-011435-x73foqu7	86	15	hatfield	hatfield	PROPN
cord-011435-x73foqu7	86	16	,	,	PUNCT
cord-011435-x73foqu7	86	17	pa	pa	PROPN
cord-011435-x73foqu7	86	18	,	,	PUNCT
cord-011435-x73foqu7	86	19	usa	usa	PROPN
cord-011435-x73foqu7	86	20	,	,	PUNCT
cord-011435-x73foqu7	86	21	#	#	SYM
cord-011435-x73foqu7	86	22	15710	15710	NUM
cord-011435-x73foqu7	86	23	)	)	PUNCT
cord-011435-x73foqu7	86	24	,	,	PUNCT
cord-011435-x73foqu7	86	25	permeabilized	permeabilize	VERB
cord-011435-x73foqu7	86	26	in	in	ADP
cord-011435-x73foqu7	86	27	0.2	0.2	NUM
cord-011435-x73foqu7	86	28	%	%	NOUN
cord-011435-x73foqu7	86	29	triton	triton	PROPN
cord-011435-x73foqu7	86	30	x-100	x-100	PROPN
cord-011435-x73foqu7	87	1	(	(	PUNCT
cord-011435-x73foqu7	87	2	fisher	fisher	NOUN
cord-011435-x73foqu7	87	3	scientific	scientific	ADJ
cord-011435-x73foqu7	87	4	#	#	SYM
cord-011435-x73foqu7	87	5	9002	9002	NUM
cord-011435-x73foqu7	87	6	-	-	SYM
cord-011435-x73foqu7	87	7	93	93	NUM
cord-011435-x73foqu7	87	8	-	-	SYM
cord-011435-x73foqu7	87	9	1	1	NUM
cord-011435-x73foqu7	87	10	)	)	PUNCT
cord-011435-x73foqu7	87	11	and	and	CCONJ
cord-011435-x73foqu7	87	12	immunostained	immunostaine	VERB
cord-011435-x73foqu7	87	13	with	with	ADP
cord-011435-x73foqu7	87	14	anti	anti	ADJ
cord-011435-x73foqu7	87	15	-	-	ADJ
cord-011435-x73foqu7	87	16	icp0	icp0	ADJ
cord-011435-x73foqu7	87	17	antibody	antibody	NOUN
cord-011435-x73foqu7	87	18	followed	follow	VERB
cord-011435-x73foqu7	87	19	by	by	ADP
cord-011435-x73foqu7	87	20	alexa	alexa	NOUN
cord-011435-x73foqu7	87	21	.	.	PUNCT
cord-011435-x73foqu7	88	1	fluor	fluor	NOUN
cord-011435-x73foqu7	88	2	-	-	PUNCT
cord-011435-x73foqu7	88	3	conjugated	conjugate	VERB
cord-011435-x73foqu7	88	4	secondary	secondary	ADJ
cord-011435-x73foqu7	88	5	antibody	antibody	NOUN
cord-011435-x73foqu7	88	6	(	(	PUNCT
cord-011435-x73foqu7	88	7	invitrogen	invitrogen	PROPN
cord-011435-x73foqu7	88	8	#	#	SYM
cord-011435-x73foqu7	88	9	a-11004	a-11004	PROPN
cord-011435-x73foqu7	88	10	)	)	PUNCT
cord-011435-x73foqu7	88	11	.	.	PUNCT
cord-011435-x73foqu7	89	1	the	the	DET
cord-011435-x73foqu7	89	2	coverslips	coverslip	NOUN
cord-011435-x73foqu7	89	3	were	be	AUX
cord-011435-x73foqu7	89	4	mounted	mount	VERB
cord-011435-x73foqu7	89	5	on	on	ADP
cord-011435-x73foqu7	89	6	microscopy	microscopy	NOUN
cord-011435-x73foqu7	89	7	slides	slide	NOUN
cord-011435-x73foqu7	89	8	using	use	VERB
cord-011435-x73foqu7	89	9	vectashield	vectashield	PROPN
cord-011435-x73foqu7	89	10	/	/	SYM
cord-011435-x73foqu7	89	11	dapi	dapi	PROPN
cord-011435-x73foqu7	89	12	(	(	PUNCT
cord-011435-x73foqu7	89	13	vector	vector	NOUN
cord-011435-x73foqu7	89	14	laboratories	laboratory	NOUN
cord-011435-x73foqu7	89	15	,	,	PUNCT
cord-011435-x73foqu7	89	16	burlingame	burlingame	PROPN
cord-011435-x73foqu7	89	17	,	,	PUNCT
cord-011435-x73foqu7	89	18	ca	can	AUX
cord-011435-x73foqu7	89	19	,	,	PUNCT
cord-011435-x73foqu7	89	20	usa	usa	PROPN
cord-011435-x73foqu7	89	21	,	,	PUNCT
cord-011435-x73foqu7	89	22	#	#	SYM
cord-011435-x73foqu7	89	23	h-1200	h-1200	X
cord-011435-x73foqu7	89	24	)	)	PUNCT
cord-011435-x73foqu7	89	25	and	and	CCONJ
cord-011435-x73foqu7	89	26	analyzed	analyze	VERB
cord-011435-x73foqu7	89	27	using	use	VERB
cord-011435-x73foqu7	89	28	an	an	DET
cord-011435-x73foqu7	89	29	olympus	olympus	PROPN
cord-011435-x73foqu7	89	30	(	(	PUNCT
cord-011435-x73foqu7	89	31	waltham	waltham	PROPN
cord-011435-x73foqu7	89	32	,	,	PUNCT
cord-011435-x73foqu7	89	33	ma	ma	PROPN
cord-011435-x73foqu7	89	34	,	,	PUNCT
cord-011435-x73foqu7	89	35	usa	usa	PROPN
cord-011435-x73foqu7	89	36	)	)	PUNCT
cord-011435-x73foqu7	89	37	confocal	confocal	PROPN
cord-011435-x73foqu7	89	38	microscope	microscope	PROPN
cord-011435-x73foqu7	89	39	and	and	CCONJ
cord-011435-x73foqu7	89	40	olympus	olympus	PROPN
cord-011435-x73foqu7	89	41	fluoview	fluoview	PROPN
cord-011435-x73foqu7	89	42	fv1000	fv1000	PROPN
cord-011435-x73foqu7	89	43	software	software	NOUN
cord-011435-x73foqu7	89	44	.	.	PUNCT
cord-011435-x73foqu7	90	1	the	the	DET
cord-011435-x73foqu7	90	2	caspase-3/7	caspase-3/7	ADJ
cord-011435-x73foqu7	90	3	activity	activity	NOUN
cord-011435-x73foqu7	90	4	of	of	ADP
cord-011435-x73foqu7	90	5	the	the	DET
cord-011435-x73foqu7	90	6	cell	cell	NOUN
cord-011435-x73foqu7	90	7	lysates	lysate	NOUN
cord-011435-x73foqu7	90	8	was	be	AUX
cord-011435-x73foqu7	90	9	performed	perform	VERB
cord-011435-x73foqu7	90	10	using	use	VERB
cord-011435-x73foqu7	90	11	previously	previously	ADV
cord-011435-x73foqu7	90	12	described	describe	VERB
cord-011435-x73foqu7	90	13	procedures	procedure	NOUN
cord-011435-x73foqu7	90	14	[	[	X
cord-011435-x73foqu7	90	15	9	9	NUM
cord-011435-x73foqu7	90	16	]	]	PUNCT
cord-011435-x73foqu7	90	17	.	.	PUNCT
cord-011435-x73foqu7	91	1	briefly	briefly	ADV
cord-011435-x73foqu7	91	2	,	,	PUNCT
cord-011435-x73foqu7	91	3	the	the	DET
cord-011435-x73foqu7	91	4	cell	cell	NOUN
cord-011435-x73foqu7	91	5	lysates	lysate	NOUN
cord-011435-x73foqu7	91	6	were	be	AUX
cord-011435-x73foqu7	91	7	used	use	VERB
cord-011435-x73foqu7	91	8	for	for	ADP
cord-011435-x73foqu7	91	9	measuring	measure	VERB
cord-011435-x73foqu7	91	10	caspase	caspase	NOUN
cord-011435-x73foqu7	91	11	activity	activity	NOUN
cord-011435-x73foqu7	91	12	using	use	VERB
cord-011435-x73foqu7	91	13	the	the	DET
cord-011435-x73foqu7	91	14	apo	apo	PROPN
cord-011435-x73foqu7	91	15	-	-	PUNCT
cord-011435-x73foqu7	91	16	onetm	onetm	NOUN
cord-011435-x73foqu7	91	17	homogeneous	homogeneous	ADJ
cord-011435-x73foqu7	91	18	caspase-3/7	caspase-3/7	ADJ
cord-011435-x73foqu7	91	19	assay	assay	NOUN
cord-011435-x73foqu7	91	20	according	accord	VERB
cord-011435-x73foqu7	91	21	to	to	ADP
cord-011435-x73foqu7	91	22	protocols	protocol	NOUN
cord-011435-x73foqu7	91	23	provided	provide	VERB
cord-011435-x73foqu7	91	24	by	by	ADP
cord-011435-x73foqu7	91	25	the	the	DET
cord-011435-x73foqu7	91	26	manufacturer	manufacturer	NOUN
cord-011435-x73foqu7	91	27	(	(	PUNCT
cord-011435-x73foqu7	91	28	promega	promega	PROPN
cord-011435-x73foqu7	91	29	)	)	PUNCT
cord-011435-x73foqu7	91	30	.	.	PUNCT
cord-011435-x73foqu7	92	1	caspase	caspase	NOUN
cord-011435-x73foqu7	92	2	activity	activity	NOUN
cord-011435-x73foqu7	92	3	in	in	ADP
cord-011435-x73foqu7	92	4	experimental	experimental	ADJ
cord-011435-x73foqu7	92	5	samples	sample	NOUN
cord-011435-x73foqu7	92	6	was	be	AUX
cord-011435-x73foqu7	92	7	plotted	plot	VERB
cord-011435-x73foqu7	92	8	relative	relative	ADJ
cord-011435-x73foqu7	92	9	to	to	ADP
cord-011435-x73foqu7	92	10	rlr	rlr	NOUN
cord-011435-x73foqu7	92	11	-	-	PUNCT
cord-011435-x73foqu7	92	12	stimulated	stimulate	VERB
cord-011435-x73foqu7	92	13	cells	cell	NOUN
cord-011435-x73foqu7	92	14	arbitrarily	arbitrarily	ADV
cord-011435-x73foqu7	92	15	set	set	VERB
cord-011435-x73foqu7	92	16	as	as	ADP
cord-011435-x73foqu7	92	17	100	100	NUM
cord-011435-x73foqu7	92	18	(	(	PUNCT
cord-011435-x73foqu7	92	19	as	as	ADP
cord-011435-x73foqu7	92	20	in	in	ADP
cord-011435-x73foqu7	92	21	figure	figure	NOUN
cord-011435-x73foqu7	92	22	1d	1d	NOUN
cord-011435-x73foqu7	92	23	)	)	PUNCT
cord-011435-x73foqu7	92	24	.	.	PUNCT
cord-011435-x73foqu7	93	1	cell	cell	NOUN
cord-011435-x73foqu7	93	2	viability	viability	NOUN
cord-011435-x73foqu7	93	3	was	be	AUX
cord-011435-x73foqu7	93	4	measured	measure	VERB
cord-011435-x73foqu7	93	5	by	by	ADP
cord-011435-x73foqu7	93	6	3-(4,5	3-(4,5	NUM
cord-011435-x73foqu7	93	7	-	-	PUNCT
cord-011435-x73foqu7	93	8	dimethylthiazol-2	dimethylthiazol-2	VERB
cord-011435-x73foqu7	93	9	-	-	PUNCT
cord-011435-x73foqu7	93	10	yl)-2,5	yl)-2,5	NOUN
cord-011435-x73foqu7	93	11	-	-	PUNCT
cord-011435-x73foqu7	93	12	diphenyltetrazolium	diphenyltetrazolium	NOUN
cord-011435-x73foqu7	93	13	bromide	bromide	NOUN
cord-011435-x73foqu7	93	14	(	(	PUNCT
cord-011435-x73foqu7	93	15	mtt	mtt	NOUN
cord-011435-x73foqu7	93	16	)	)	PUNCT
cord-011435-x73foqu7	93	17	assay	assay	NOUN
cord-011435-x73foqu7	93	18	,	,	PUNCT
cord-011435-x73foqu7	93	19	trypan	trypan	NOUN
cord-011435-x73foqu7	93	20	blue	blue	ADJ
cord-011435-x73foqu7	93	21	exclusion	exclusion	NOUN
cord-011435-x73foqu7	93	22	,	,	PUNCT
cord-011435-x73foqu7	93	23	and	and	CCONJ
cord-011435-x73foqu7	93	24	brightfield	brightfield	ADJ
cord-011435-x73foqu7	93	25	microscopy	microscopy	NOUN
cord-011435-x73foqu7	93	26	.	.	PUNCT
cord-011435-x73foqu7	94	1	to	to	PART
cord-011435-x73foqu7	94	2	measure	measure	VERB
cord-011435-x73foqu7	94	3	cell	cell	NOUN
cord-011435-x73foqu7	94	4	viability	viability	NOUN
cord-011435-x73foqu7	94	5	,	,	PUNCT
cord-011435-x73foqu7	94	6	the	the	DET
cord-011435-x73foqu7	94	7	cells	cell	NOUN
cord-011435-x73foqu7	94	8	were	be	AUX
cord-011435-x73foqu7	94	9	seeded	seed	VERB
cord-011435-x73foqu7	94	10	in	in	ADP
cord-011435-x73foqu7	94	11	a	a	DET
cord-011435-x73foqu7	94	12	96	96	NUM
cord-011435-x73foqu7	94	13	-	-	PUNCT
cord-011435-x73foqu7	94	14	well	well	NOUN
cord-011435-x73foqu7	94	15	plate	plate	NOUN
cord-011435-x73foqu7	94	16	,	,	PUNCT
cord-011435-x73foqu7	94	17	and	and	CCONJ
cord-011435-x73foqu7	94	18	transfected	transfecte	VERB
cord-011435-x73foqu7	94	19	(	(	PUNCT
cord-011435-x73foqu7	94	20	rlr	rlr	NOUN
cord-011435-x73foqu7	94	21	)	)	PUNCT
cord-011435-x73foqu7	94	22	or	or	CCONJ
cord-011435-x73foqu7	94	23	treated	treat	VERB
cord-011435-x73foqu7	94	24	(	(	PUNCT
cord-011435-x73foqu7	94	25	tlr3	tlr3	PROPN
cord-011435-x73foqu7	94	26	)	)	PUNCT
cord-011435-x73foqu7	94	27	with	with	ADP
cord-011435-x73foqu7	94	28	polyi	polyi	PROPN
cord-011435-x73foqu7	94	29	:	:	PUNCT
cord-011435-x73foqu7	94	30	c	c	X
cord-011435-x73foqu7	94	31	in	in	ADP
cord-011435-x73foqu7	94	32	the	the	DET
cord-011435-x73foqu7	94	33	absence	absence	NOUN
cord-011435-x73foqu7	94	34	or	or	CCONJ
cord-011435-x73foqu7	94	35	the	the	DET
cord-011435-x73foqu7	94	36	presence	presence	NOUN
cord-011435-x73foqu7	94	37	of	of	ADP
cord-011435-x73foqu7	94	38	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	94	39	or	or	CCONJ
cord-011435-x73foqu7	94	40	vehicle	vehicle	NOUN
cord-011435-x73foqu7	94	41	(	(	PUNCT
cord-011435-x73foqu7	94	42	dmso	dmso	PROPN
cord-011435-x73foqu7	94	43	)	)	PUNCT
cord-011435-x73foqu7	94	44	,	,	PUNCT
cord-011435-x73foqu7	94	45	as	as	SCONJ
cord-011435-x73foqu7	94	46	indicated	indicate	VERB
cord-011435-x73foqu7	94	47	,	,	PUNCT
cord-011435-x73foqu7	94	48	for	for	ADP
cord-011435-x73foqu7	94	49	24	24	NUM
cord-011435-x73foqu7	94	50	h.	h.	NOUN
cord-011435-x73foqu7	94	51	the	the	DET
cord-011435-x73foqu7	94	52	mtt	mtt	ADJ
cord-011435-x73foqu7	94	53	assay	assay	NOUN
cord-011435-x73foqu7	94	54	was	be	AUX
cord-011435-x73foqu7	94	55	performed	perform	VERB
cord-011435-x73foqu7	94	56	using	use	VERB
cord-011435-x73foqu7	94	57	previously	previously	ADV
cord-011435-x73foqu7	94	58	described	describe	VERB
cord-011435-x73foqu7	94	59	procedures	procedure	NOUN
cord-011435-x73foqu7	94	60	[	[	X
cord-011435-x73foqu7	94	61	26	26	NUM
cord-011435-x73foqu7	94	62	]	]	PUNCT
cord-011435-x73foqu7	94	63	.	.	PUNCT
cord-011435-x73foqu7	95	1	the	the	DET
cord-011435-x73foqu7	95	2	absorbance	absorbance	NOUN
cord-011435-x73foqu7	95	3	of	of	ADP
cord-011435-x73foqu7	95	4	the	the	DET
cord-011435-x73foqu7	95	5	treated	treat	VERB
cord-011435-x73foqu7	95	6	cells	cell	NOUN
cord-011435-x73foqu7	95	7	was	be	AUX
cord-011435-x73foqu7	95	8	considered	consider	VERB
cord-011435-x73foqu7	95	9	as	as	ADP
cord-011435-x73foqu7	95	10	100	100	NUM
cord-011435-x73foqu7	95	11	,	,	PUNCT
cord-011435-x73foqu7	95	12	and	and	CCONJ
cord-011435-x73foqu7	95	13	the	the	DET
cord-011435-x73foqu7	95	14	other	other	ADJ
cord-011435-x73foqu7	95	15	values	value	NOUN
cord-011435-x73foqu7	95	16	were	be	AUX
cord-011435-x73foqu7	95	17	normalized	normalize	VERB
cord-011435-x73foqu7	95	18	to	to	ADP
cord-011435-x73foqu7	95	19	this	this	PRON
cord-011435-x73foqu7	95	20	.	.	PUNCT
cord-011435-x73foqu7	96	1	for	for	ADP
cord-011435-x73foqu7	96	2	the	the	DET
cord-011435-x73foqu7	96	3	trypan	trypan	NOUN
cord-011435-x73foqu7	96	4	blue	blue	ADJ
cord-011435-x73foqu7	96	5	exclusion	exclusion	NOUN
cord-011435-x73foqu7	96	6	assay	assay	NOUN
cord-011435-x73foqu7	96	7	,	,	PUNCT
cord-011435-x73foqu7	96	8	the	the	DET
cord-011435-x73foqu7	96	9	treated	treat	VERB
cord-011435-x73foqu7	96	10	cells	cell	NOUN
cord-011435-x73foqu7	96	11	were	be	AUX
cord-011435-x73foqu7	96	12	trypsinized	trypsinize	VERB
cord-011435-x73foqu7	96	13	,	,	PUNCT
cord-011435-x73foqu7	96	14	resuspended	resuspend	VERB
cord-011435-x73foqu7	96	15	in	in	ADP
cord-011435-x73foqu7	96	16	complete	complete	ADJ
cord-011435-x73foqu7	96	17	dmem	dmem	NOUN
cord-011435-x73foqu7	96	18	,	,	PUNCT
cord-011435-x73foqu7	96	19	stained	stain	VERB
cord-011435-x73foqu7	96	20	with	with	ADP
cord-011435-x73foqu7	96	21	trypan	trypan	NOUN
cord-011435-x73foqu7	96	22	blue	blue	ADJ
cord-011435-x73foqu7	96	23	and	and	CCONJ
cord-011435-x73foqu7	96	24	the	the	DET
cord-011435-x73foqu7	96	25	live	live	ADJ
cord-011435-x73foqu7	96	26	and	and	CCONJ
cord-011435-x73foqu7	96	27	dead	dead	ADJ
cord-011435-x73foqu7	96	28	cells	cell	NOUN
cord-011435-x73foqu7	96	29	were	be	AUX
cord-011435-x73foqu7	96	30	counted	count	VERB
cord-011435-x73foqu7	96	31	using	use	VERB
cord-011435-x73foqu7	96	32	a	a	DET
cord-011435-x73foqu7	96	33	hemocytometer	hemocytometer	NOUN
cord-011435-x73foqu7	96	34	to	to	PART
cord-011435-x73foqu7	96	35	calculate	calculate	VERB
cord-011435-x73foqu7	96	36	percent	percent	NOUN
cord-011435-x73foqu7	96	37	viability	viability	NOUN
cord-011435-x73foqu7	96	38	for	for	ADP
cord-011435-x73foqu7	96	39	each	each	DET
cord-011435-x73foqu7	96	40	treatment	treatment	NOUN
cord-011435-x73foqu7	96	41	.	.	PUNCT
cord-011435-x73foqu7	97	1	the	the	DET
cord-011435-x73foqu7	97	2	statistical	statistical	ADJ
cord-011435-x73foqu7	97	3	analyses	analysis	NOUN
cord-011435-x73foqu7	97	4	were	be	AUX
cord-011435-x73foqu7	97	5	performed	perform	VERB
cord-011435-x73foqu7	97	6	using	use	VERB
cord-011435-x73foqu7	97	7	graphpad	graphpad	PROPN
cord-011435-x73foqu7	97	8	prism	prism	PROPN
cord-011435-x73foqu7	97	9	5.02	5.02	NUM
cord-011435-x73foqu7	97	10	software	software	NOUN
cord-011435-x73foqu7	97	11	.	.	PUNCT
cord-011435-x73foqu7	98	1	the	the	DET
cord-011435-x73foqu7	98	2	"	"	PUNCT
cord-011435-x73foqu7	98	3	p	p	NOUN
cord-011435-x73foqu7	98	4	"	"	PUNCT
cord-011435-x73foqu7	98	5	values	value	NOUN
cord-011435-x73foqu7	98	6	were	be	AUX
cord-011435-x73foqu7	98	7	calculated	calculate	VERB
cord-011435-x73foqu7	98	8	using	use	VERB
cord-011435-x73foqu7	98	9	two	two	NUM
cord-011435-x73foqu7	98	10	-	-	PUNCT
cord-011435-x73foqu7	98	11	tailed	tail	VERB
cord-011435-x73foqu7	98	12	,	,	PUNCT
cord-011435-x73foqu7	98	13	unpaired	unpaired	ADJ
cord-011435-x73foqu7	98	14	student	student	NOUN
cord-011435-x73foqu7	98	15	's	's	PART
cord-011435-x73foqu7	98	16	t	t	NOUN
cord-011435-x73foqu7	98	17	-	-	PUNCT
cord-011435-x73foqu7	98	18	tests	test	NOUN
cord-011435-x73foqu7	98	19	and	and	CCONJ
cord-011435-x73foqu7	98	20	are	be	AUX
cord-011435-x73foqu7	98	21	shown	show	VERB
cord-011435-x73foqu7	98	22	in	in	ADP
cord-011435-x73foqu7	98	23	the	the	DET
cord-011435-x73foqu7	98	24	relevant	relevant	ADJ
cord-011435-x73foqu7	98	25	figures	figure	NOUN
cord-011435-x73foqu7	98	26	.	.	PUNCT
cord-011435-x73foqu7	99	1	the	the	DET
cord-011435-x73foqu7	99	2	results	result	NOUN
cord-011435-x73foqu7	99	3	presented	present	VERB
cord-011435-x73foqu7	99	4	here	here	ADV
cord-011435-x73foqu7	99	5	are	be	AUX
cord-011435-x73foqu7	99	6	the	the	DET
cord-011435-x73foqu7	99	7	representatives	representative	NOUN
cord-011435-x73foqu7	99	8	of	of	ADP
cord-011435-x73foqu7	99	9	at	at	ADV
cord-011435-x73foqu7	99	10	least	least	ADV
cord-011435-x73foqu7	99	11	three	three	NUM
cord-011435-x73foqu7	99	12	biological	biological	ADJ
cord-011435-x73foqu7	99	13	repeats	repeat	NOUN
cord-011435-x73foqu7	99	14	.	.	PUNCT
cord-011435-x73foqu7	100	1	to	to	PART
cord-011435-x73foqu7	100	2	identify	identify	VERB
cord-011435-x73foqu7	100	3	small	small	ADJ
cord-011435-x73foqu7	100	4	molecule	molecule	NOUN
cord-011435-x73foqu7	100	5	activators	activator	NOUN
cord-011435-x73foqu7	100	6	of	of	ADP
cord-011435-x73foqu7	100	7	the	the	DET
cord-011435-x73foqu7	100	8	antiviral	antiviral	ADJ
cord-011435-x73foqu7	100	9	ripa	ripa	PROPN
cord-011435-x73foqu7	100	10	branch	branch	PROPN
cord-011435-x73foqu7	100	11	of	of	ADP
cord-011435-x73foqu7	100	12	irf3	irf3	PROPN
cord-011435-x73foqu7	100	13	(	(	PUNCT
cord-011435-x73foqu7	100	14	figure	figure	VERB
cord-011435-x73foqu7	100	15	1a	1a	NUM
cord-011435-x73foqu7	100	16	)	)	PUNCT
cord-011435-x73foqu7	100	17	,	,	PUNCT
cord-011435-x73foqu7	100	18	we	we	PRON
cord-011435-x73foqu7	100	19	performed	perform	VERB
cord-011435-x73foqu7	100	20	an	an	DET
cord-011435-x73foqu7	100	21	unbiased	unbiased	ADJ
cord-011435-x73foqu7	100	22	high	high	ADJ
cord-011435-x73foqu7	100	23	throughput	throughput	NOUN
cord-011435-x73foqu7	100	24	screen	screen	NOUN
cord-011435-x73foqu7	100	25	using	use	VERB
cord-011435-x73foqu7	100	26	a	a	DET
cord-011435-x73foqu7	100	27	library	library	NOUN
cord-011435-x73foqu7	100	28	of	of	ADP
cord-011435-x73foqu7	100	29	fda	fda	PROPN
cord-011435-x73foqu7	100	30	-	-	PUNCT
cord-011435-x73foqu7	100	31	approved	approve	VERB
cord-011435-x73foqu7	100	32	compounds	compound	NOUN
cord-011435-x73foqu7	100	33	.	.	PUNCT
cord-011435-x73foqu7	101	1	activation	activation	NOUN
cord-011435-x73foqu7	101	2	of	of	ADP
cord-011435-x73foqu7	101	3	ripa	ripa	PROPN
cord-011435-x73foqu7	101	4	,	,	PUNCT
cord-011435-x73foqu7	101	5	by	by	ADP
cord-011435-x73foqu7	101	6	transfection	transfection	NOUN
cord-011435-x73foqu7	101	7	of	of	ADP
cord-011435-x73foqu7	101	8	the	the	DET
cord-011435-x73foqu7	101	9	rlr	rlr	NOUN
cord-011435-x73foqu7	101	10	ligand	ligand	NOUN
cord-011435-x73foqu7	101	11	polyi	polyi	NOUN
cord-011435-x73foqu7	101	12	:	:	PUNCT
cord-011435-x73foqu7	101	13	c	c	X
cord-011435-x73foqu7	101	14	,	,	PUNCT
cord-011435-x73foqu7	101	15	caused	cause	VERB
cord-011435-x73foqu7	101	16	robust	robust	ADJ
cord-011435-x73foqu7	101	17	cell	cell	NOUN
cord-011435-x73foqu7	101	18	death	death	NOUN
cord-011435-x73foqu7	101	19	(	(	PUNCT
cord-011435-x73foqu7	101	20	figure	figure	NOUN
cord-011435-x73foqu7	101	21	1b	1b	NUM
cord-011435-x73foqu7	101	22	,	,	PUNCT
cord-011435-x73foqu7	101	23	stage-5	stage-5	NOUN
cord-011435-x73foqu7	101	24	,	,	PUNCT
cord-011435-x73foqu7	101	25	figure	figure	VERB
cord-011435-x73foqu7	101	26	1a	1a	NUM
cord-011435-x73foqu7	101	27	)	)	PUNCT
cord-011435-x73foqu7	101	28	.	.	PUNCT
cord-011435-x73foqu7	102	1	stimulation	stimulation	NOUN
cord-011435-x73foqu7	102	2	of	of	ADP
cord-011435-x73foqu7	102	3	tlr3	tlr3	NOUN
cord-011435-x73foqu7	102	4	or	or	CCONJ
cord-011435-x73foqu7	102	5	sting	sting	NOUN
cord-011435-x73foqu7	102	6	,	,	PUNCT
cord-011435-x73foqu7	102	7	by	by	ADP
cord-011435-x73foqu7	102	8	their	their	PRON
cord-011435-x73foqu7	102	9	cognate	cognate	ADJ
cord-011435-x73foqu7	102	10	ligands	ligand	NOUN
cord-011435-x73foqu7	102	11	,	,	PUNCT
cord-011435-x73foqu7	102	12	did	do	AUX
cord-011435-x73foqu7	102	13	not	not	PART
cord-011435-x73foqu7	102	14	cause	cause	VERB
cord-011435-x73foqu7	102	15	visible	visible	ADJ
cord-011435-x73foqu7	102	16	cell	cell	NOUN
cord-011435-x73foqu7	102	17	death	death	NOUN
cord-011435-x73foqu7	102	18	(	(	PUNCT
cord-011435-x73foqu7	102	19	figure	figure	NOUN
cord-011435-x73foqu7	102	20	1b	1b	NUM
cord-011435-x73foqu7	102	21	)	)	PUNCT
cord-011435-x73foqu7	102	22	.	.	PUNCT
cord-011435-x73foqu7	103	1	cleaved	cleave	VERB
cord-011435-x73foqu7	103	2	parp	parp	PROPN
cord-011435-x73foqu7	103	3	(	(	PUNCT
cord-011435-x73foqu7	103	4	c	c	NOUN
cord-011435-x73foqu7	103	5	-	-	NOUN
cord-011435-x73foqu7	103	6	parp	parp	ADJ
cord-011435-x73foqu7	103	7	,	,	PUNCT
cord-011435-x73foqu7	103	8	stage-4	stage-4	NOUN
cord-011435-x73foqu7	103	9	,	,	PUNCT
cord-011435-x73foqu7	103	10	figure	figure	VERB
cord-011435-x73foqu7	103	11	1a	1a	NUM
cord-011435-x73foqu7	103	12	)	)	PUNCT
cord-011435-x73foqu7	103	13	,	,	PUNCT
cord-011435-x73foqu7	103	14	a	a	DET
cord-011435-x73foqu7	103	15	molecular	molecular	ADJ
cord-011435-x73foqu7	103	16	marker	marker	NOUN
cord-011435-x73foqu7	103	17	of	of	ADP
cord-011435-x73foqu7	103	18	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	103	19	,	,	PUNCT
cord-011435-x73foqu7	103	20	was	be	AUX
cord-011435-x73foqu7	103	21	observed	observe	VERB
cord-011435-x73foqu7	103	22	in	in	ADP
cord-011435-x73foqu7	103	23	rlr-	rlr-	NOUN
cord-011435-x73foqu7	103	24	,	,	PUNCT
cord-011435-x73foqu7	103	25	but	but	CCONJ
cord-011435-x73foqu7	103	26	not	not	PART
cord-011435-x73foqu7	103	27	sting	sting	NOUN
cord-011435-x73foqu7	103	28	-	-	PUNCT
cord-011435-x73foqu7	103	29	stimulated	stimulate	VERB
cord-011435-x73foqu7	103	30	,	,	PUNCT
cord-011435-x73foqu7	103	31	cells	cell	NOUN
cord-011435-x73foqu7	103	32	.	.	PUNCT
cord-011435-x73foqu7	104	1	as	as	SCONJ
cord-011435-x73foqu7	104	2	expected	expect	VERB
cord-011435-x73foqu7	104	3	,	,	PUNCT
cord-011435-x73foqu7	104	4	the	the	DET
cord-011435-x73foqu7	104	5	apoptotic	apoptotic	ADJ
cord-011435-x73foqu7	104	6	executioner	executioner	NOUN
cord-011435-x73foqu7	104	7	caspase	caspase	NOUN
cord-011435-x73foqu7	104	8	,	,	PUNCT
cord-011435-x73foqu7	104	9	caspase-3	caspase-3	NUM
cord-011435-x73foqu7	104	10	(	(	PUNCT
cord-011435-x73foqu7	104	11	stage-3	stage-3	NUM
cord-011435-x73foqu7	104	12	,	,	PUNCT
cord-011435-x73foqu7	104	13	figure	figure	VERB
cord-011435-x73foqu7	104	14	1a	1a	NUM
cord-011435-x73foqu7	104	15	)	)	PUNCT
cord-011435-x73foqu7	104	16	,	,	PUNCT
cord-011435-x73foqu7	104	17	was	be	AUX
cord-011435-x73foqu7	104	18	strongly	strongly	ADV
cord-011435-x73foqu7	104	19	activated	activate	VERB
cord-011435-x73foqu7	104	20	only	only	ADV
cord-011435-x73foqu7	104	21	upon	upon	SCONJ
cord-011435-x73foqu7	104	22	rlr	rlr	NOUN
cord-011435-x73foqu7	104	23	,	,	PUNCT
cord-011435-x73foqu7	104	24	but	but	CCONJ
cord-011435-x73foqu7	104	25	not	not	PART
cord-011435-x73foqu7	104	26	tlr3	tlr3	NOUN
cord-011435-x73foqu7	104	27	or	or	CCONJ
cord-011435-x73foqu7	104	28	sting	ste	VERB
cord-011435-x73foqu7	104	29	,	,	PUNCT
cord-011435-x73foqu7	104	30	stimulation	stimulation	NOUN
cord-011435-x73foqu7	104	31	for	for	ADP
cord-011435-x73foqu7	104	32	an	an	DET
cord-011435-x73foqu7	104	33	increasing	increase	VERB
cord-011435-x73foqu7	104	34	time	time	NOUN
cord-011435-x73foqu7	104	35	period	period	NOUN
cord-011435-x73foqu7	104	36	(	(	PUNCT
cord-011435-x73foqu7	104	37	figure	figure	NOUN
cord-011435-x73foqu7	104	38	1d	1d	NOUN
cord-011435-x73foqu7	104	39	,	,	PUNCT
cord-011435-x73foqu7	104	40	e	e	NOUN
cord-011435-x73foqu7	104	41	)	)	PUNCT
cord-011435-x73foqu7	104	42	.	.	PUNCT
cord-011435-x73foqu7	105	1	therefore	therefore	ADV
cord-011435-x73foqu7	105	2	,	,	PUNCT
cord-011435-x73foqu7	105	3	we	we	PRON
cord-011435-x73foqu7	105	4	optimized	optimize	VERB
cord-011435-x73foqu7	105	5	conditions	condition	NOUN
cord-011435-x73foqu7	105	6	to	to	PART
cord-011435-x73foqu7	105	7	screen	screen	VERB
cord-011435-x73foqu7	105	8	for	for	ADP
cord-011435-x73foqu7	105	9	agents	agent	NOUN
cord-011435-x73foqu7	105	10	that	that	PRON
cord-011435-x73foqu7	105	11	specifically	specifically	ADV
cord-011435-x73foqu7	105	12	modulate	modulate	VERB
cord-011435-x73foqu7	105	13	ripa	ripa	ADJ
cord-011435-x73foqu7	105	14	-	-	PUNCT
cord-011435-x73foqu7	105	15	induced	induce	VERB
cord-011435-x73foqu7	105	16	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	105	17	,	,	PUNCT
cord-011435-x73foqu7	105	18	without	without	ADP
cord-011435-x73foqu7	105	19	the	the	DET
cord-011435-x73foqu7	105	20	need	need	NOUN
cord-011435-x73foqu7	105	21	to	to	PART
cord-011435-x73foqu7	105	22	separate	separate	VERB
cord-011435-x73foqu7	105	23	the	the	DET
cord-011435-x73foqu7	105	24	contribution	contribution	NOUN
cord-011435-x73foqu7	105	25	of	of	ADP
cord-011435-x73foqu7	105	26	tlr3	tlr3	NOUN
cord-011435-x73foqu7	105	27	or	or	CCONJ
cord-011435-x73foqu7	105	28	sting	ste	VERB
cord-011435-x73foqu7	105	29	pathways	pathway	NOUN
cord-011435-x73foqu7	105	30	.	.	PUNCT
cord-011435-x73foqu7	106	1	to	to	PART
cord-011435-x73foqu7	106	2	isolate	isolate	VERB
cord-011435-x73foqu7	106	3	the	the	DET
cord-011435-x73foqu7	106	4	activators	activator	NOUN
cord-011435-x73foqu7	106	5	of	of	ADP
cord-011435-x73foqu7	106	6	ripa	ripa	PROPN
cord-011435-x73foqu7	106	7	,	,	PUNCT
cord-011435-x73foqu7	106	8	we	we	PRON
cord-011435-x73foqu7	106	9	performed	perform	VERB
cord-011435-x73foqu7	106	10	a	a	DET
cord-011435-x73foqu7	106	11	high	high	ADJ
cord-011435-x73foqu7	106	12	throughput	throughput	NOUN
cord-011435-x73foqu7	106	13	screen	screen	NOUN
cord-011435-x73foqu7	106	14	of	of	ADP
cord-011435-x73foqu7	106	15	a	a	DET
cord-011435-x73foqu7	106	16	library	library	NOUN
cord-011435-x73foqu7	106	17	consisting	consist	VERB
cord-011435-x73foqu7	106	18	of	of	ADP
cord-011435-x73foqu7	106	19	1200	1200	NUM
cord-011435-x73foqu7	106	20	fda	fda	PROPN
cord-011435-x73foqu7	106	21	-	-	PUNCT
cord-011435-x73foqu7	106	22	approved	approve	VERB
cord-011435-x73foqu7	106	23	compounds	compound	NOUN
cord-011435-x73foqu7	106	24	[	[	X
cord-011435-x73foqu7	106	25	27	27	NUM
cord-011435-x73foqu7	106	26	]	]	PUNCT
cord-011435-x73foqu7	106	27	.	.	PUNCT
cord-011435-x73foqu7	107	1	the	the	DET
cord-011435-x73foqu7	107	2	library	library	NOUN
cord-011435-x73foqu7	107	3	is	be	AUX
cord-011435-x73foqu7	107	4	96	96	NUM
cord-011435-x73foqu7	107	5	-	-	PUNCT
cord-011435-x73foqu7	107	6	well	well	NOUN
cord-011435-x73foqu7	107	7	formatted	format	VERB
cord-011435-x73foqu7	107	8	with	with	ADP
cord-011435-x73foqu7	107	9	each	each	DET
cord-011435-x73foqu7	107	10	well	well	ADV
cord-011435-x73foqu7	107	11	containing	contain	VERB
cord-011435-x73foqu7	107	12	an	an	DET
cord-011435-x73foqu7	107	13	individual	individual	ADJ
cord-011435-x73foqu7	107	14	compound	compound	NOUN
cord-011435-x73foqu7	107	15	.	.	PUNCT
cord-011435-x73foqu7	108	1	we	we	PRON
cord-011435-x73foqu7	108	2	performed	perform	VERB
cord-011435-x73foqu7	108	3	the	the	DET
cord-011435-x73foqu7	108	4	primary	primary	ADJ
cord-011435-x73foqu7	108	5	screen	screen	NOUN
cord-011435-x73foqu7	108	6	using	use	VERB
cord-011435-x73foqu7	108	7	the	the	DET
cord-011435-x73foqu7	108	8	strategy	strategy	NOUN
cord-011435-x73foqu7	108	9	outlined	outline	VERB
cord-011435-x73foqu7	108	10	in	in	ADP
cord-011435-x73foqu7	108	11	figure	figure	NOUN
cord-011435-x73foqu7	108	12	1f	1f	NUM
cord-011435-x73foqu7	108	13	,	,	PUNCT
cord-011435-x73foqu7	108	14	and	and	CCONJ
cord-011435-x73foqu7	108	15	the	the	DET
cord-011435-x73foqu7	108	16	activity	activity	NOUN
cord-011435-x73foqu7	108	17	of	of	ADP
cord-011435-x73foqu7	108	18	caspase-3	caspase-3	PROPN
cord-011435-x73foqu7	108	19	was	be	AUX
cord-011435-x73foqu7	108	20	used	use	VERB
cord-011435-x73foqu7	108	21	as	as	ADP
cord-011435-x73foqu7	108	22	a	a	DET
cord-011435-x73foqu7	108	23	readout	readout	NOUN
cord-011435-x73foqu7	108	24	of	of	ADP
cord-011435-x73foqu7	108	25	the	the	DET
cord-011435-x73foqu7	108	26	ripa	ripa	ADJ
cord-011435-x73foqu7	108	27	activity	activity	NOUN
cord-011435-x73foqu7	108	28	in	in	ADP
cord-011435-x73foqu7	108	29	each	each	DET
cord-011435-x73foqu7	108	30	well	well	NOUN
cord-011435-x73foqu7	108	31	.	.	PUNCT
cord-011435-x73foqu7	109	1	the	the	DET
cord-011435-x73foqu7	109	2	caspase-3	caspase-3	PROPN
cord-011435-x73foqu7	109	3	activity	activity	NOUN
cord-011435-x73foqu7	109	4	of	of	ADP
cord-011435-x73foqu7	109	5	vehicle	vehicle	NOUN
cord-011435-x73foqu7	109	6	(	(	PUNCT
cord-011435-x73foqu7	109	7	dmso)-treated	dmso)-treate	VERB
cord-011435-x73foqu7	109	8	well	well	ADV
cord-011435-x73foqu7	109	9	was	be	AUX
cord-011435-x73foqu7	109	10	arbitrarily	arbitrarily	ADV
cord-011435-x73foqu7	109	11	set	set	VERB
cord-011435-x73foqu7	109	12	at	at	ADP
cord-011435-x73foqu7	109	13	100	100	NUM
cord-011435-x73foqu7	109	14	,	,	PUNCT
cord-011435-x73foqu7	109	15	and	and	CCONJ
cord-011435-x73foqu7	109	16	all	all	DET
cord-011435-x73foqu7	109	17	other	other	ADJ
cord-011435-x73foqu7	109	18	values	value	NOUN
cord-011435-x73foqu7	109	19	were	be	AUX
cord-011435-x73foqu7	109	20	normalized	normalize	VERB
cord-011435-x73foqu7	109	21	to	to	ADP
cord-011435-x73foqu7	109	22	this	this	PRON
cord-011435-x73foqu7	109	23	(	(	PUNCT
cord-011435-x73foqu7	109	24	a	a	DET
cord-011435-x73foqu7	109	25	sample	sample	NOUN
cord-011435-x73foqu7	109	26	plate	plate	NOUN
cord-011435-x73foqu7	109	27	is	be	AUX
cord-011435-x73foqu7	109	28	shown	show	VERB
cord-011435-x73foqu7	109	29	in	in	ADP
cord-011435-x73foqu7	109	30	figure	figure	NOUN
cord-011435-x73foqu7	109	31	s1	s1	PROPN
cord-011435-x73foqu7	109	32	)	)	PUNCT
cord-011435-x73foqu7	109	33	.	.	PUNCT
cord-011435-x73foqu7	110	1	the	the	DET
cord-011435-x73foqu7	110	2	primary	primary	ADJ
cord-011435-x73foqu7	110	3	screen	screen	NOUN
cord-011435-x73foqu7	110	4	resulted	result	VERB
cord-011435-x73foqu7	110	5	in	in	ADP
cord-011435-x73foqu7	110	6	several	several	ADJ
cord-011435-x73foqu7	110	7	ripa	ripa	NOUN
cord-011435-x73foqu7	110	8	activators	activator	NOUN
cord-011435-x73foqu7	110	9	,	,	PUNCT
cord-011435-x73foqu7	110	10	and	and	CCONJ
cord-011435-x73foqu7	110	11	using	use	VERB
cord-011435-x73foqu7	110	12	an	an	DET
cord-011435-x73foqu7	110	13	arbitrary	arbitrary	ADJ
cord-011435-x73foqu7	110	14	cut	cut	NOUN
cord-011435-x73foqu7	110	15	-	-	PUNCT
cord-011435-x73foqu7	110	16	off	off	NOUN
cord-011435-x73foqu7	110	17	of	of	ADP
cord-011435-x73foqu7	110	18	z	z	NOUN
cord-011435-x73foqu7	110	19	-	-	NOUN
cord-011435-x73foqu7	110	20	scores	score	NOUN
cord-011435-x73foqu7	110	21	greater	great	ADJ
cord-011435-x73foqu7	110	22	than	than	ADP
cord-011435-x73foqu7	110	23	1.15	1.15	NUM
cord-011435-x73foqu7	110	24	,	,	PUNCT
cord-011435-x73foqu7	110	25	we	we	PRON
cord-011435-x73foqu7	110	26	obtained	obtain	VERB
cord-011435-x73foqu7	110	27	twenty	twenty	NUM
cord-011435-x73foqu7	110	28	-	-	PUNCT
cord-011435-x73foqu7	110	29	five	five	NUM
cord-011435-x73foqu7	110	30	candidate	candidate	NOUN
cord-011435-x73foqu7	110	31	ripa	ripa	NOUN
cord-011435-x73foqu7	110	32	activating	activate	VERB
cord-011435-x73foqu7	110	33	compounds	compound	NOUN
cord-011435-x73foqu7	110	34	(	(	PUNCT
cord-011435-x73foqu7	110	35	figure	figure	NOUN
cord-011435-x73foqu7	110	36	2a	2a	NUM
cord-011435-x73foqu7	110	37	,	,	PUNCT
cord-011435-x73foqu7	110	38	b	b	NOUN
cord-011435-x73foqu7	110	39	,	,	PUNCT
cord-011435-x73foqu7	110	40	table	table	NOUN
cord-011435-x73foqu7	110	41	s1	s1	PROPN
cord-011435-x73foqu7	110	42	)	)	PUNCT
cord-011435-x73foqu7	110	43	.	.	PUNCT
cord-011435-x73foqu7	111	1	we	we	PRON
cord-011435-x73foqu7	111	2	noted	note	VERB
cord-011435-x73foqu7	111	3	that	that	SCONJ
cord-011435-x73foqu7	111	4	the	the	DET
cord-011435-x73foqu7	111	5	ripa	ripa	NOUN
cord-011435-x73foqu7	111	6	activators	activator	NOUN
cord-011435-x73foqu7	111	7	constitute	constitute	VERB
cord-011435-x73foqu7	111	8	only	only	ADV
cord-011435-x73foqu7	111	9	2	2	NUM
cord-011435-x73foqu7	111	10	%	%	NOUN
cord-011435-x73foqu7	111	11	of	of	ADP
cord-011435-x73foqu7	111	12	the	the	DET
cord-011435-x73foqu7	111	13	library	library	NOUN
cord-011435-x73foqu7	111	14	,	,	PUNCT
cord-011435-x73foqu7	111	15	indicating	indicate	VERB
cord-011435-x73foqu7	111	16	the	the	DET
cord-011435-x73foqu7	111	17	specificities	specificity	NOUN
cord-011435-x73foqu7	111	18	of	of	ADP
cord-011435-x73foqu7	111	19	the	the	DET
cord-011435-x73foqu7	111	20	compounds	compound	NOUN
cord-011435-x73foqu7	111	21	.	.	PUNCT
cord-011435-x73foqu7	112	1	the	the	DET
cord-011435-x73foqu7	112	2	primary	primary	ADJ
cord-011435-x73foqu7	112	3	hits	hit	NOUN
cord-011435-x73foqu7	112	4	were	be	AUX
cord-011435-x73foqu7	112	5	validated	validate	VERB
cord-011435-x73foqu7	112	6	using	use	VERB
cord-011435-x73foqu7	112	7	a	a	DET
cord-011435-x73foqu7	112	8	secondary	secondary	ADJ
cord-011435-x73foqu7	112	9	screen	screen	NOUN
cord-011435-x73foqu7	112	10	,	,	PUNCT
cord-011435-x73foqu7	112	11	and	and	CCONJ
cord-011435-x73foqu7	112	12	the	the	DET
cord-011435-x73foqu7	112	13	ripa	ripa	ADV
cord-011435-x73foqu7	112	14	-	-	PUNCT
cord-011435-x73foqu7	112	15	promoting	promote	VERB
cord-011435-x73foqu7	112	16	activity	activity	NOUN
cord-011435-x73foqu7	112	17	of	of	ADP
cord-011435-x73foqu7	112	18	each	each	DET
cord-011435-x73foqu7	112	19	compound	compound	NOUN
cord-011435-x73foqu7	112	20	was	be	AUX
cord-011435-x73foqu7	112	21	determined	determine	VERB
cord-011435-x73foqu7	112	22	with	with	ADP
cord-011435-x73foqu7	112	23	respect	respect	NOUN
cord-011435-x73foqu7	112	24	to	to	ADP
cord-011435-x73foqu7	112	25	the	the	DET
cord-011435-x73foqu7	112	26	vehicle	vehicle	NOUN
cord-011435-x73foqu7	112	27	control	control	NOUN
cord-011435-x73foqu7	112	28	.	.	PUNCT
cord-011435-x73foqu7	113	1	the	the	DET
cord-011435-x73foqu7	113	2	secondary	secondary	ADJ
cord-011435-x73foqu7	113	3	screen	screen	NOUN
cord-011435-x73foqu7	113	4	validated	validate	VERB
cord-011435-x73foqu7	113	5	twenty	twenty	NUM
cord-011435-x73foqu7	113	6	-	-	PUNCT
cord-011435-x73foqu7	113	7	four	four	NUM
cord-011435-x73foqu7	113	8	of	of	ADP
cord-011435-x73foqu7	113	9	the	the	DET
cord-011435-x73foqu7	113	10	twenty	twenty	NUM
cord-011435-x73foqu7	113	11	-	-	PUNCT
cord-011435-x73foqu7	113	12	five	five	NUM
cord-011435-x73foqu7	113	13	compounds	compound	NOUN
cord-011435-x73foqu7	113	14	obtained	obtain	VERB
cord-011435-x73foqu7	113	15	from	from	ADP
cord-011435-x73foqu7	113	16	the	the	DET
cord-011435-x73foqu7	113	17	primary	primary	ADJ
cord-011435-x73foqu7	113	18	screen	screen	NOUN
cord-011435-x73foqu7	113	19	(	(	PUNCT
cord-011435-x73foqu7	113	20	figure	figure	NOUN
cord-011435-x73foqu7	113	21	2c	2c	NUM
cord-011435-x73foqu7	113	22	)	)	PUNCT
cord-011435-x73foqu7	113	23	.	.	PUNCT
cord-011435-x73foqu7	114	1	the	the	DET
cord-011435-x73foqu7	114	2	secondary	secondary	ADJ
cord-011435-x73foqu7	114	3	-	-	PUNCT
cord-011435-x73foqu7	114	4	validated	validate	VERB
cord-011435-x73foqu7	114	5	ripa	ripa	NOUN
cord-011435-x73foqu7	114	6	-	-	PUNCT
cord-011435-x73foqu7	114	7	activators	activator	NOUN
cord-011435-x73foqu7	114	8	consisted	consist	VERB
cord-011435-x73foqu7	114	9	of	of	ADP
cord-011435-x73foqu7	114	10	compounds	compound	NOUN
cord-011435-x73foqu7	114	11	from	from	ADP
cord-011435-x73foqu7	114	12	a	a	DET
cord-011435-x73foqu7	114	13	variety	variety	NOUN
cord-011435-x73foqu7	114	14	of	of	ADP
cord-011435-x73foqu7	114	15	therapeutic	therapeutic	ADJ
cord-011435-x73foqu7	114	16	activities	activity	NOUN
cord-011435-x73foqu7	114	17	,	,	PUNCT
cord-011435-x73foqu7	114	18	e.g.	e.g.	ADV
cord-011435-x73foqu7	114	19	,	,	PUNCT
cord-011435-x73foqu7	114	20	anticancer	anticancer	NOUN
cord-011435-x73foqu7	114	21	,	,	PUNCT
cord-011435-x73foqu7	114	22	antibacterial	antibacterial	ADJ
cord-011435-x73foqu7	114	23	,	,	PUNCT
cord-011435-x73foqu7	114	24	anti	anti	ADJ
cord-011435-x73foqu7	114	25	-	-	ADJ
cord-011435-x73foqu7	114	26	inflammatory	inflammatory	ADJ
cord-011435-x73foqu7	114	27	,	,	PUNCT
cord-011435-x73foqu7	114	28	antihypertensive	antihypertensive	ADJ
cord-011435-x73foqu7	114	29	,	,	PUNCT
cord-011435-x73foqu7	114	30	etc	etc	X
cord-011435-x73foqu7	114	31	(	(	PUNCT
cord-011435-x73foqu7	114	32	figure	figure	NOUN
cord-011435-x73foqu7	114	33	2b	2b	NUM
cord-011435-x73foqu7	114	34	)	)	PUNCT
cord-011435-x73foqu7	114	35	.	.	PUNCT
cord-011435-x73foqu7	115	1	we	we	PRON
cord-011435-x73foqu7	115	2	excluded	exclude	VERB
cord-011435-x73foqu7	115	3	act1	act1	PROPN
cord-011435-x73foqu7	115	4	,	,	PUNCT
cord-011435-x73foqu7	115	5	which	which	PRON
cord-011435-x73foqu7	115	6	triggered	trigger	VERB
cord-011435-x73foqu7	115	7	caspase-3	caspase-3	NUM
cord-011435-x73foqu7	115	8	activity	activity	NOUN
cord-011435-x73foqu7	115	9	nonspecifically	nonspecifically	ADV
cord-011435-x73foqu7	115	10	,	,	PUNCT
cord-011435-x73foqu7	115	11	from	from	ADP
cord-011435-x73foqu7	115	12	the	the	DET
cord-011435-x73foqu7	115	13	subsequent	subsequent	ADJ
cord-011435-x73foqu7	115	14	studies	study	NOUN
cord-011435-x73foqu7	115	15	,	,	PUNCT
cord-011435-x73foqu7	115	16	and	and	CCONJ
cord-011435-x73foqu7	115	17	focused	focus	VERB
cord-011435-x73foqu7	115	18	on	on	ADP
cord-011435-x73foqu7	115	19	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	115	20	,	,	PUNCT
cord-011435-x73foqu7	115	21	which	which	PRON
cord-011435-x73foqu7	115	22	has	have	AUX
cord-011435-x73foqu7	115	23	earlier	early	ADV
cord-011435-x73foqu7	115	24	been	be	AUX
cord-011435-x73foqu7	115	25	studied	study	VERB
cord-011435-x73foqu7	115	26	to	to	PART
cord-011435-x73foqu7	115	27	activate	activate	VERB
cord-011435-x73foqu7	115	28	irf3	irf3	PROPN
cord-011435-x73foqu7	115	29	[	[	PUNCT
cord-011435-x73foqu7	115	30	28	28	NUM
cord-011435-x73foqu7	115	31	]	]	PUNCT
cord-011435-x73foqu7	115	32	.	.	PUNCT
cord-011435-x73foqu7	116	1	because	because	SCONJ
cord-011435-x73foqu7	116	2	ripa	ripa	PROPN
cord-011435-x73foqu7	116	3	contributes	contribute	VERB
cord-011435-x73foqu7	116	4	to	to	ADP
cord-011435-x73foqu7	116	5	the	the	DET
cord-011435-x73foqu7	116	6	antiviral	antiviral	ADJ
cord-011435-x73foqu7	116	7	function	function	NOUN
cord-011435-x73foqu7	116	8	of	of	ADP
cord-011435-x73foqu7	116	9	irf3	irf3	PROPN
cord-011435-x73foqu7	116	10	[	[	PUNCT
cord-011435-x73foqu7	116	11	7	7	NUM
cord-011435-x73foqu7	116	12	]	]	PUNCT
cord-011435-x73foqu7	116	13	,	,	PUNCT
cord-011435-x73foqu7	116	14	we	we	PRON
cord-011435-x73foqu7	116	15	hypothesized	hypothesize	VERB
cord-011435-x73foqu7	116	16	that	that	SCONJ
cord-011435-x73foqu7	116	17	agents	agent	NOUN
cord-011435-x73foqu7	116	18	that	that	PRON
cord-011435-x73foqu7	116	19	promote	promote	VERB
cord-011435-x73foqu7	116	20	ripa	ripa	NOUN
cord-011435-x73foqu7	116	21	would	would	AUX
cord-011435-x73foqu7	116	22	inhibit	inhibit	VERB
cord-011435-x73foqu7	116	23	viral	viral	ADJ
cord-011435-x73foqu7	116	24	replication	replication	NOUN
cord-011435-x73foqu7	116	25	.	.	PUNCT
cord-011435-x73foqu7	117	1	for	for	ADP
cord-011435-x73foqu7	117	2	this	this	DET
cord-011435-x73foqu7	117	3	purpose	purpose	NOUN
cord-011435-x73foqu7	117	4	,	,	PUNCT
cord-011435-x73foqu7	117	5	we	we	PRON
cord-011435-x73foqu7	117	6	used	use	VERB
cord-011435-x73foqu7	117	7	vesicular	vesicular	ADJ
cord-011435-x73foqu7	117	8	stomatitis	stomatitis	PROPN
cord-011435-x73foqu7	117	9	virus	virus	NOUN
cord-011435-x73foqu7	117	10	(	(	PUNCT
cord-011435-x73foqu7	117	11	vsv	vsv	PROPN
cord-011435-x73foqu7	117	12	)	)	PUNCT
cord-011435-x73foqu7	117	13	as	as	ADP
cord-011435-x73foqu7	117	14	a	a	DET
cord-011435-x73foqu7	117	15	model	model	ADJ
cord-011435-x73foqu7	117	16	negative	negative	ADJ
cord-011435-x73foqu7	117	17	-	-	PUNCT
cord-011435-x73foqu7	117	18	sense	sense	NOUN
cord-011435-x73foqu7	117	19	rna	rna	PROPN
cord-011435-x73foqu7	117	20	virus	virus	NOUN
cord-011435-x73foqu7	117	21	.	.	PUNCT
cord-011435-x73foqu7	118	1	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	118	2	treatment	treatment	PROPN
cord-011435-x73foqu7	118	3	inhibited	inhibit	VERB
cord-011435-x73foqu7	118	4	vsv	vsv	PROPN
cord-011435-x73foqu7	118	5	replication	replication	PROPN
cord-011435-x73foqu7	118	6	,	,	PUNCT
cord-011435-x73foqu7	118	7	analyzed	analyze	VERB
cord-011435-x73foqu7	118	8	by	by	ADP
cord-011435-x73foqu7	118	9	virus	virus	NOUN
cord-011435-x73foqu7	118	10	-	-	PUNCT
cord-011435-x73foqu7	118	11	encoded	encode	VERB
cord-011435-x73foqu7	118	12	gfp	gfp	NOUN
cord-011435-x73foqu7	118	13	expression	expression	NOUN
cord-011435-x73foqu7	118	14	(	(	PUNCT
cord-011435-x73foqu7	118	15	figure	figure	NOUN
cord-011435-x73foqu7	118	16	3a	3a	NUM
cord-011435-x73foqu7	118	17	)	)	PUNCT
cord-011435-x73foqu7	118	18	.	.	PUNCT
cord-011435-x73foqu7	119	1	we	we	PRON
cord-011435-x73foqu7	119	2	validated	validate	VERB
cord-011435-x73foqu7	119	3	these	these	DET
cord-011435-x73foqu7	119	4	results	result	NOUN
cord-011435-x73foqu7	119	5	by	by	ADP
cord-011435-x73foqu7	119	6	immunoblot	immunoblot	NOUN
cord-011435-x73foqu7	119	7	analyses	analysis	NOUN
cord-011435-x73foqu7	119	8	,	,	PUNCT
cord-011435-x73foqu7	119	9	which	which	PRON
cord-011435-x73foqu7	119	10	demonstrate	demonstrate	VERB
cord-011435-x73foqu7	119	11	that	that	SCONJ
cord-011435-x73foqu7	119	12	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	119	13	treatment	treatment	NOUN
cord-011435-x73foqu7	119	14	inhibited	inhibit	VERB
cord-011435-x73foqu7	119	15	the	the	DET
cord-011435-x73foqu7	119	16	expression	expression	NOUN
cord-011435-x73foqu7	119	17	of	of	ADP
cord-011435-x73foqu7	119	18	vsv	vsv	PROPN
cord-011435-x73foqu7	119	19	-	-	PUNCT
cord-011435-x73foqu7	119	20	g	g	NOUN
cord-011435-x73foqu7	119	21	protein	protein	NOUN
cord-011435-x73foqu7	119	22	,	,	PUNCT
cord-011435-x73foqu7	119	23	a	a	DET
cord-011435-x73foqu7	119	24	viral	viral	ADJ
cord-011435-x73foqu7	119	25	envelope	envelope	NOUN
cord-011435-x73foqu7	119	26	glycoprotein	glycoprotein	NOUN
cord-011435-x73foqu7	119	27	as	as	ADV
cord-011435-x73foqu7	119	28	well	well	ADV
cord-011435-x73foqu7	119	29	as	as	ADP
cord-011435-x73foqu7	119	30	the	the	DET
cord-011435-x73foqu7	119	31	virus	virus	NOUN
cord-011435-x73foqu7	119	32	-	-	PUNCT
cord-011435-x73foqu7	119	33	encoded	encode	VERB
cord-011435-x73foqu7	119	34	gfp	gfp	NOUN
cord-011435-x73foqu7	119	35	(	(	PUNCT
cord-011435-x73foqu7	119	36	figure	figure	NOUN
cord-011435-x73foqu7	119	37	3b	3b	NUM
cord-011435-x73foqu7	119	38	)	)	PUNCT
cord-011435-x73foqu7	119	39	.	.	PUNCT
cord-011435-x73foqu7	120	1	as	as	SCONJ
cord-011435-x73foqu7	120	2	expected	expect	VERB
cord-011435-x73foqu7	120	3	,	,	PUNCT
cord-011435-x73foqu7	120	4	the	the	DET
cord-011435-x73foqu7	120	5	reduced	reduce	VERB
cord-011435-x73foqu7	120	6	viral	viral	ADJ
cord-011435-x73foqu7	120	7	protein	protein	NOUN
cord-011435-x73foqu7	120	8	expression	expression	NOUN
cord-011435-x73foqu7	120	9	led	lead	VERB
cord-011435-x73foqu7	120	10	to	to	ADP
cord-011435-x73foqu7	120	11	reduced	reduce	VERB
cord-011435-x73foqu7	120	12	infectious	infectious	ADJ
cord-011435-x73foqu7	120	13	virus	virus	NOUN
cord-011435-x73foqu7	120	14	particle	particle	NOUN
cord-011435-x73foqu7	120	15	release	release	NOUN
cord-011435-x73foqu7	120	16	from	from	ADP
cord-011435-x73foqu7	120	17	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	120	18	-	-	PUNCT
cord-011435-x73foqu7	120	19	treated	treat	VERB
cord-011435-x73foqu7	120	20	cells	cell	NOUN
cord-011435-x73foqu7	120	21	(	(	PUNCT
cord-011435-x73foqu7	120	22	figure	figure	NOUN
cord-011435-x73foqu7	120	23	3c	3c	NUM
cord-011435-x73foqu7	120	24	)	)	PUNCT
cord-011435-x73foqu7	120	25	.	.	PUNCT
cord-011435-x73foqu7	121	1	we	we	PRON
cord-011435-x73foqu7	121	2	validated	validate	VERB
cord-011435-x73foqu7	121	3	the	the	DET
cord-011435-x73foqu7	121	4	results	result	NOUN
cord-011435-x73foqu7	121	5	in	in	ADP
cord-011435-x73foqu7	121	6	another	another	DET
cord-011435-x73foqu7	121	7	cell	cell	NOUN
cord-011435-x73foqu7	121	8	line	line	NOUN
cord-011435-x73foqu7	121	9	(	(	PUNCT
cord-011435-x73foqu7	121	10	a549	a549	PROPN
cord-011435-x73foqu7	121	11	)	)	PUNCT
cord-011435-x73foqu7	121	12	,	,	PUNCT
cord-011435-x73foqu7	121	13	in	in	ADP
cord-011435-x73foqu7	121	14	which	which	PRON
cord-011435-x73foqu7	121	15	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	121	16	also	also	ADV
cord-011435-x73foqu7	121	17	inhibited	inhibit	VERB
cord-011435-x73foqu7	121	18	vsv	vsv	PROPN
cord-011435-x73foqu7	121	19	-	-	PUNCT
cord-011435-x73foqu7	121	20	encoded	encode	VERB
cord-011435-x73foqu7	121	21	gfp	gfp	NOUN
cord-011435-x73foqu7	121	22	expression	expression	NOUN
cord-011435-x73foqu7	121	23	(	(	PUNCT
cord-011435-x73foqu7	121	24	figure	figure	NOUN
cord-011435-x73foqu7	121	25	3d	3d	NOUN
cord-011435-x73foqu7	121	26	)	)	PUNCT
cord-011435-x73foqu7	121	27	.	.	PUNCT
cord-011435-x73foqu7	122	1	to	to	PART
cord-011435-x73foqu7	122	2	determine	determine	VERB
cord-011435-x73foqu7	122	3	whether	whether	SCONJ
cord-011435-x73foqu7	122	4	the	the	DET
cord-011435-x73foqu7	122	5	antiviral	antiviral	ADJ
cord-011435-x73foqu7	122	6	activity	activity	NOUN
cord-011435-x73foqu7	122	7	of	of	ADP
cord-011435-x73foqu7	122	8	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	122	9	is	be	AUX
cord-011435-x73foqu7	122	10	dependent	dependent	ADJ
cord-011435-x73foqu7	122	11	on	on	ADP
cord-011435-x73foqu7	122	12	irf3	irf3	PROPN
cord-011435-x73foqu7	122	13	,	,	PUNCT
cord-011435-x73foqu7	122	14	we	we	PRON
cord-011435-x73foqu7	122	15	generated	generate	VERB
cord-011435-x73foqu7	122	16	irf3	irf3	PROPN
cord-011435-x73foqu7	122	17	−/−	−/−	PROPN
cord-011435-x73foqu7	122	18	human	human	ADJ
cord-011435-x73foqu7	122	19	cells	cell	NOUN
cord-011435-x73foqu7	122	20	(	(	PUNCT
cord-011435-x73foqu7	122	21	ht1080	ht1080	PROPN
cord-011435-x73foqu7	122	22	)	)	PUNCT
cord-011435-x73foqu7	122	23	using	use	VERB
cord-011435-x73foqu7	122	24	a	a	DET
cord-011435-x73foqu7	122	25	crispr	crispr	ADJ
cord-011435-x73foqu7	122	26	/	/	SYM
cord-011435-x73foqu7	122	27	cas9	cas9	NOUN
cord-011435-x73foqu7	122	28	approach	approach	NOUN
cord-011435-x73foqu7	122	29	(	(	PUNCT
cord-011435-x73foqu7	122	30	figure	figure	NOUN
cord-011435-x73foqu7	122	31	3e	3e	X
cord-011435-x73foqu7	122	32	,	,	PUNCT
cord-011435-x73foqu7	122	33	lower	low	ADJ
cord-011435-x73foqu7	122	34	panel	panel	NOUN
cord-011435-x73foqu7	122	35	,	,	PUNCT
cord-011435-x73foqu7	122	36	figure	figure	NOUN
cord-011435-x73foqu7	122	37	s2	s2	PROPN
cord-011435-x73foqu7	122	38	)	)	PUNCT
cord-011435-x73foqu7	122	39	.	.	PUNCT
cord-011435-x73foqu7	123	1	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	123	2	,	,	PUNCT
cord-011435-x73foqu7	123	3	as	as	SCONJ
cord-011435-x73foqu7	123	4	expected	expect	VERB
cord-011435-x73foqu7	123	5	,	,	PUNCT
cord-011435-x73foqu7	123	6	inhibited	inhibit	VERB
cord-011435-x73foqu7	123	7	the	the	DET
cord-011435-x73foqu7	123	8	viral	viral	ADJ
cord-011435-x73foqu7	123	9	protein	protein	NOUN
cord-011435-x73foqu7	123	10	expression	expression	NOUN
cord-011435-x73foqu7	123	11	in	in	ADP
cord-011435-x73foqu7	123	12	the	the	DET
cord-011435-x73foqu7	123	13	wt	wt	PROPN
cord-011435-x73foqu7	123	14	cells	cell	NOUN
cord-011435-x73foqu7	123	15	;	;	PUNCT
cord-011435-x73foqu7	123	16	however	however	ADV
cord-011435-x73foqu7	123	17	,	,	PUNCT
cord-011435-x73foqu7	123	18	the	the	DET
cord-011435-x73foqu7	123	19	antiviral	antiviral	ADJ
cord-011435-x73foqu7	123	20	activity	activity	NOUN
cord-011435-x73foqu7	123	21	of	of	ADP
cord-011435-x73foqu7	123	22	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	123	23	was	be	AUX
cord-011435-x73foqu7	123	24	impaired	impair	VERB
cord-011435-x73foqu7	123	25	in	in	ADP
cord-011435-x73foqu7	123	26	irf3	irf3	PROPN
cord-011435-x73foqu7	123	27	−/−	−/−	NUM
cord-011435-x73foqu7	123	28	cells	cell	NOUN
cord-011435-x73foqu7	123	29	(	(	PUNCT
cord-011435-x73foqu7	123	30	figure	figure	NOUN
cord-011435-x73foqu7	123	31	3e	3e	X
cord-011435-x73foqu7	123	32	,	,	PUNCT
cord-011435-x73foqu7	123	33	top	top	ADJ
cord-011435-x73foqu7	123	34	panel	panel	NOUN
cord-011435-x73foqu7	123	35	)	)	PUNCT
cord-011435-x73foqu7	123	36	.	.	PUNCT
cord-011435-x73foqu7	124	1	to	to	PART
cord-011435-x73foqu7	124	2	further	far	ADV
cord-011435-x73foqu7	124	3	validate	validate	VERB
cord-011435-x73foqu7	124	4	this	this	DET
cord-011435-x73foqu7	124	5	striking	striking	ADJ
cord-011435-x73foqu7	124	6	result	result	NOUN
cord-011435-x73foqu7	124	7	,	,	PUNCT
cord-011435-x73foqu7	124	8	we	we	PRON
cord-011435-x73foqu7	124	9	used	use	VERB
cord-011435-x73foqu7	124	10	wt	wt	PROPN
cord-011435-x73foqu7	124	11	and	and	CCONJ
cord-011435-x73foqu7	124	12	irf3	irf3	PROPN
cord-011435-x73foqu7	124	13	−/−	−/−	PRON
cord-011435-x73foqu7	124	14	mouse	mouse	NOUN
cord-011435-x73foqu7	124	15	embryonic	embryonic	NOUN
cord-011435-x73foqu7	124	16	fibroblasts	fibroblast	NOUN
cord-011435-x73foqu7	124	17	(	(	PUNCT
cord-011435-x73foqu7	124	18	mefs	mef	NOUN
cord-011435-x73foqu7	124	19	)	)	PUNCT
cord-011435-x73foqu7	124	20	(	(	PUNCT
cord-011435-x73foqu7	124	21	figure	figure	NOUN
cord-011435-x73foqu7	124	22	3f	3f	PROPN
cord-011435-x73foqu7	124	23	,	,	PUNCT
cord-011435-x73foqu7	124	24	lower	low	ADJ
cord-011435-x73foqu7	124	25	panel	panel	NOUN
cord-011435-x73foqu7	124	26	)	)	PUNCT
cord-011435-x73foqu7	124	27	.	.	PUNCT
cord-011435-x73foqu7	125	1	similar	similar	ADJ
cord-011435-x73foqu7	125	2	to	to	ADP
cord-011435-x73foqu7	125	3	the	the	DET
cord-011435-x73foqu7	125	4	human	human	ADJ
cord-011435-x73foqu7	125	5	cells	cell	NOUN
cord-011435-x73foqu7	125	6	,	,	PUNCT
cord-011435-x73foqu7	125	7	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	125	8	inhibited	inhibited	PROPN
cord-011435-x73foqu7	125	9	vsv	vsv	PROPN
cord-011435-x73foqu7	125	10	replication	replication	NOUN
cord-011435-x73foqu7	125	11	only	only	ADV
cord-011435-x73foqu7	125	12	in	in	ADP
cord-011435-x73foqu7	125	13	the	the	DET
cord-011435-x73foqu7	125	14	presence	presence	NOUN
cord-011435-x73foqu7	125	15	of	of	ADP
cord-011435-x73foqu7	125	16	irf3	irf3	PROPN
cord-011435-x73foqu7	125	17	(	(	PUNCT
cord-011435-x73foqu7	125	18	figure	figure	VERB
cord-011435-x73foqu7	125	19	3f	3f	PROPN
cord-011435-x73foqu7	125	20	,	,	PUNCT
cord-011435-x73foqu7	125	21	top	top	ADJ
cord-011435-x73foqu7	125	22	panel	panel	NOUN
cord-011435-x73foqu7	125	23	)	)	PUNCT
cord-011435-x73foqu7	125	24	.	.	PUNCT
cord-011435-x73foqu7	126	1	we	we	PRON
cord-011435-x73foqu7	126	2	further	far	ADV
cord-011435-x73foqu7	126	3	quantified	quantify	VERB
cord-011435-x73foqu7	126	4	,	,	PUNCT
cord-011435-x73foqu7	126	5	in	in	ADP
cord-011435-x73foqu7	126	6	addition	addition	NOUN
cord-011435-x73foqu7	126	7	to	to	ADP
cord-011435-x73foqu7	126	8	viral	viral	ADJ
cord-011435-x73foqu7	126	9	g	g	PROPN
cord-011435-x73foqu7	126	10	protein	protein	NOUN
cord-011435-x73foqu7	126	11	,	,	PUNCT
cord-011435-x73foqu7	126	12	the	the	DET
cord-011435-x73foqu7	126	13	expression	expression	NOUN
cord-011435-x73foqu7	126	14	of	of	ADP
cord-011435-x73foqu7	126	15	vsv	vsv	PROPN
cord-011435-x73foqu7	126	16	-	-	PUNCT
cord-011435-x73foqu7	126	17	encoded	encode	VERB
cord-011435-x73foqu7	126	18	gfp	gfp	PROPN
cord-011435-x73foqu7	126	19	fluorescence	fluorescence	PROPN
cord-011435-x73foqu7	126	20	.	.	PUNCT
cord-011435-x73foqu7	127	1	similar	similar	ADJ
cord-011435-x73foqu7	127	2	to	to	ADP
cord-011435-x73foqu7	127	3	the	the	DET
cord-011435-x73foqu7	127	4	inhibition	inhibition	NOUN
cord-011435-x73foqu7	127	5	of	of	ADP
cord-011435-x73foqu7	127	6	g	g	NOUN
cord-011435-x73foqu7	127	7	protein	protein	NOUN
cord-011435-x73foqu7	127	8	expression	expression	NOUN
cord-011435-x73foqu7	127	9	,	,	PUNCT
cord-011435-x73foqu7	127	10	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	127	11	inhibited	inhibit	VERB
cord-011435-x73foqu7	127	12	gfp	gfp	PROPN
cord-011435-x73foqu7	127	13	fluorescence	fluorescence	PROPN
cord-011435-x73foqu7	127	14	in	in	ADP
cord-011435-x73foqu7	127	15	wt	wt	PROPN
cord-011435-x73foqu7	127	16	but	but	CCONJ
cord-011435-x73foqu7	127	17	not	not	PART
cord-011435-x73foqu7	127	18	irf3	irf3	NOUN
cord-011435-x73foqu7	127	19	-	-	PUNCT
cord-011435-x73foqu7	127	20	deficient	deficient	ADJ
cord-011435-x73foqu7	127	21	cells	cell	NOUN
cord-011435-x73foqu7	127	22	(	(	PUNCT
cord-011435-x73foqu7	127	23	figure	figure	NOUN
cord-011435-x73foqu7	127	24	3e	3e	PROPN
cord-011435-x73foqu7	127	25	,	,	PUNCT
cord-011435-x73foqu7	127	26	f	f	X
cord-011435-x73foqu7	127	27	)	)	PUNCT
cord-011435-x73foqu7	127	28	.	.	PUNCT
cord-011435-x73foqu7	128	1	we	we	PRON
cord-011435-x73foqu7	128	2	ensured	ensure	VERB
cord-011435-x73foqu7	128	3	that	that	SCONJ
cord-011435-x73foqu7	128	4	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	128	5	did	do	AUX
cord-011435-x73foqu7	128	6	not	not	PART
cord-011435-x73foqu7	128	7	cause	cause	VERB
cord-011435-x73foqu7	128	8	substantial	substantial	ADJ
cord-011435-x73foqu7	128	9	cytotoxicity	cytotoxicity	NOUN
cord-011435-x73foqu7	128	10	under	under	ADP
cord-011435-x73foqu7	128	11	our	our	PRON
cord-011435-x73foqu7	128	12	experimental	experimental	ADJ
cord-011435-x73foqu7	128	13	conditions	condition	NOUN
cord-011435-x73foqu7	128	14	(	(	PUNCT
cord-011435-x73foqu7	128	15	figure	figure	NOUN
cord-011435-x73foqu7	128	16	s3a	s3a	PROPN
cord-011435-x73foqu7	128	17	,	,	PUNCT
cord-011435-x73foqu7	128	18	b	b	PROPN
cord-011435-x73foqu7	128	19	)	)	PUNCT
cord-011435-x73foqu7	128	20	.	.	PUNCT
cord-011435-x73foqu7	129	1	our	our	PRON
cord-011435-x73foqu7	129	2	results	result	NOUN
cord-011435-x73foqu7	129	3	demonstrate	demonstrate	VERB
cord-011435-x73foqu7	129	4	,	,	PUNCT
cord-011435-x73foqu7	129	5	for	for	ADP
cord-011435-x73foqu7	129	6	the	the	DET
cord-011435-x73foqu7	129	7	first	first	ADJ
cord-011435-x73foqu7	129	8	time	time	NOUN
cord-011435-x73foqu7	129	9	,	,	PUNCT
cord-011435-x73foqu7	129	10	that	that	SCONJ
cord-011435-x73foqu7	129	11	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	129	12	is	be	AUX
cord-011435-x73foqu7	129	13	a	a	DET
cord-011435-x73foqu7	129	14	ripa	ripa	ADV
cord-011435-x73foqu7	129	15	-	-	PUNCT
cord-011435-x73foqu7	129	16	promoting	promote	VERB
cord-011435-x73foqu7	129	17	agent	agent	NOUN
cord-011435-x73foqu7	129	18	,	,	PUNCT
cord-011435-x73foqu7	129	19	which	which	PRON
cord-011435-x73foqu7	129	20	inhibits	inhibit	VERB
cord-011435-x73foqu7	129	21	viral	viral	ADJ
cord-011435-x73foqu7	129	22	infection	infection	NOUN
cord-011435-x73foqu7	129	23	in	in	ADP
cord-011435-x73foqu7	129	24	an	an	DET
cord-011435-x73foqu7	129	25	irf3	irf3	NOUN
cord-011435-x73foqu7	129	26	-	-	PUNCT
cord-011435-x73foqu7	129	27	dependent	dependent	ADJ
cord-011435-x73foqu7	129	28	manner	manner	NOUN
cord-011435-x73foqu7	129	29	.	.	PUNCT
cord-011435-x73foqu7	130	1	because	because	SCONJ
cord-011435-x73foqu7	130	2	ripa	ripa	PROPN
cord-011435-x73foqu7	130	3	contributes	contribute	VERB
cord-011435-x73foqu7	130	4	to	to	ADP
cord-011435-x73foqu7	130	5	the	the	DET
cord-011435-x73foqu7	130	6	antiviral	antiviral	ADJ
cord-011435-x73foqu7	130	7	function	function	NOUN
cord-011435-x73foqu7	130	8	of	of	ADP
cord-011435-x73foqu7	130	9	irf3	irf3	PROPN
cord-011435-x73foqu7	130	10	[	[	PUNCT
cord-011435-x73foqu7	130	11	7	7	NUM
cord-011435-x73foqu7	130	12	]	]	PUNCT
cord-011435-x73foqu7	130	13	,	,	PUNCT
cord-011435-x73foqu7	130	14	we	we	PRON
cord-011435-x73foqu7	130	15	hypothesized	hypothesize	VERB
cord-011435-x73foqu7	130	16	that	that	SCONJ
cord-011435-x73foqu7	130	17	agents	agent	NOUN
cord-011435-x73foqu7	130	18	that	that	PRON
cord-011435-x73foqu7	130	19	promote	promote	VERB
cord-011435-x73foqu7	130	20	ripa	ripa	NOUN
cord-011435-x73foqu7	130	21	would	would	AUX
cord-011435-x73foqu7	130	22	inhibit	inhibit	VERB
cord-011435-x73foqu7	130	23	viral	viral	ADJ
cord-011435-x73foqu7	130	24	replication	replication	NOUN
cord-011435-x73foqu7	130	25	.	.	PUNCT
cord-011435-x73foqu7	131	1	for	for	ADP
cord-011435-x73foqu7	131	2	this	this	DET
cord-011435-x73foqu7	131	3	purpose	purpose	NOUN
cord-011435-x73foqu7	131	4	,	,	PUNCT
cord-011435-x73foqu7	131	5	we	we	PRON
cord-011435-x73foqu7	131	6	used	use	VERB
cord-011435-x73foqu7	131	7	vesicular	vesicular	ADJ
cord-011435-x73foqu7	131	8	stomatitis	stomatitis	PROPN
cord-011435-x73foqu7	131	9	virus	virus	NOUN
cord-011435-x73foqu7	131	10	(	(	PUNCT
cord-011435-x73foqu7	131	11	vsv	vsv	PROPN
cord-011435-x73foqu7	131	12	)	)	PUNCT
cord-011435-x73foqu7	131	13	as	as	ADP
cord-011435-x73foqu7	131	14	a	a	DET
cord-011435-x73foqu7	131	15	model	model	ADJ
cord-011435-x73foqu7	131	16	negative	negative	ADJ
cord-011435-x73foqu7	131	17	-	-	PUNCT
cord-011435-x73foqu7	131	18	sense	sense	NOUN
cord-011435-x73foqu7	131	19	rna	rna	PROPN
cord-011435-x73foqu7	131	20	virus	virus	NOUN
cord-011435-x73foqu7	131	21	.	.	PUNCT
cord-011435-x73foqu7	132	1	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	132	2	treatment	treatment	PROPN
cord-011435-x73foqu7	132	3	inhibited	inhibit	VERB
cord-011435-x73foqu7	132	4	vsv	vsv	PROPN
cord-011435-x73foqu7	132	5	replication	replication	PROPN
cord-011435-x73foqu7	132	6	,	,	PUNCT
cord-011435-x73foqu7	132	7	analyzed	analyze	VERB
cord-011435-x73foqu7	132	8	by	by	ADP
cord-011435-x73foqu7	132	9	virus	virus	NOUN
cord-011435-x73foqu7	132	10	-	-	PUNCT
cord-011435-x73foqu7	132	11	encoded	encode	VERB
cord-011435-x73foqu7	132	12	gfp	gfp	NOUN
cord-011435-x73foqu7	132	13	expression	expression	NOUN
cord-011435-x73foqu7	132	14	(	(	PUNCT
cord-011435-x73foqu7	132	15	figure	figure	NOUN
cord-011435-x73foqu7	132	16	3a	3a	NUM
cord-011435-x73foqu7	132	17	)	)	PUNCT
cord-011435-x73foqu7	132	18	.	.	PUNCT
cord-011435-x73foqu7	133	1	we	we	PRON
cord-011435-x73foqu7	133	2	validated	validate	VERB
cord-011435-x73foqu7	133	3	these	these	DET
cord-011435-x73foqu7	133	4	results	result	NOUN
cord-011435-x73foqu7	133	5	by	by	ADP
cord-011435-x73foqu7	133	6	immunoblot	immunoblot	NOUN
cord-011435-x73foqu7	133	7	analyses	analysis	NOUN
cord-011435-x73foqu7	133	8	,	,	PUNCT
cord-011435-x73foqu7	133	9	which	which	PRON
cord-011435-x73foqu7	133	10	demonstrate	demonstrate	VERB
cord-011435-x73foqu7	133	11	that	that	SCONJ
cord-011435-x73foqu7	133	12	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	133	13	treatment	treatment	NOUN
cord-011435-x73foqu7	133	14	inhibited	inhibit	VERB
cord-011435-x73foqu7	133	15	the	the	DET
cord-011435-x73foqu7	133	16	expression	expression	NOUN
cord-011435-x73foqu7	133	17	of	of	ADP
cord-011435-x73foqu7	133	18	vsv	vsv	PROPN
cord-011435-x73foqu7	133	19	-	-	PUNCT
cord-011435-x73foqu7	133	20	g	g	NOUN
cord-011435-x73foqu7	133	21	protein	protein	NOUN
cord-011435-x73foqu7	133	22	,	,	PUNCT
cord-011435-x73foqu7	133	23	a	a	DET
cord-011435-x73foqu7	133	24	viral	viral	ADJ
cord-011435-x73foqu7	133	25	envelope	envelope	NOUN
cord-011435-x73foqu7	133	26	glycoprotein	glycoprotein	NOUN
cord-011435-x73foqu7	133	27	as	as	ADV
cord-011435-x73foqu7	133	28	well	well	ADV
cord-011435-x73foqu7	133	29	as	as	ADP
cord-011435-x73foqu7	133	30	the	the	DET
cord-011435-x73foqu7	133	31	virus	virus	NOUN
cord-011435-x73foqu7	133	32	-	-	PUNCT
cord-011435-x73foqu7	133	33	encoded	encode	VERB
cord-011435-x73foqu7	133	34	gfp	gfp	NOUN
cord-011435-x73foqu7	133	35	(	(	PUNCT
cord-011435-x73foqu7	133	36	figure	figure	NOUN
cord-011435-x73foqu7	133	37	3b	3b	NUM
cord-011435-x73foqu7	133	38	)	)	PUNCT
cord-011435-x73foqu7	133	39	.	.	PUNCT
cord-011435-x73foqu7	134	1	as	as	SCONJ
cord-011435-x73foqu7	134	2	expected	expect	VERB
cord-011435-x73foqu7	134	3	,	,	PUNCT
cord-011435-x73foqu7	134	4	the	the	DET
cord-011435-x73foqu7	134	5	reduced	reduce	VERB
cord-011435-x73foqu7	134	6	viral	viral	ADJ
cord-011435-x73foqu7	134	7	protein	protein	NOUN
cord-011435-x73foqu7	134	8	expression	expression	NOUN
cord-011435-x73foqu7	134	9	led	lead	VERB
cord-011435-x73foqu7	134	10	to	to	ADP
cord-011435-x73foqu7	134	11	reduced	reduce	VERB
cord-011435-x73foqu7	134	12	infectious	infectious	ADJ
cord-011435-x73foqu7	134	13	virus	virus	NOUN
cord-011435-x73foqu7	134	14	particle	particle	NOUN
cord-011435-x73foqu7	134	15	release	release	NOUN
cord-011435-x73foqu7	134	16	from	from	ADP
cord-011435-x73foqu7	134	17	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	134	18	-	-	PUNCT
cord-011435-x73foqu7	134	19	treated	treat	VERB
cord-011435-x73foqu7	134	20	cells	cell	NOUN
cord-011435-x73foqu7	134	21	(	(	PUNCT
cord-011435-x73foqu7	134	22	figure	figure	NOUN
cord-011435-x73foqu7	134	23	3c	3c	NUM
cord-011435-x73foqu7	134	24	)	)	PUNCT
cord-011435-x73foqu7	134	25	.	.	PUNCT
cord-011435-x73foqu7	135	1	we	we	PRON
cord-011435-x73foqu7	135	2	validated	validate	VERB
cord-011435-x73foqu7	135	3	the	the	DET
cord-011435-x73foqu7	135	4	results	result	NOUN
cord-011435-x73foqu7	135	5	in	in	ADP
cord-011435-x73foqu7	135	6	another	another	DET
cord-011435-x73foqu7	135	7	cell	cell	NOUN
cord-011435-x73foqu7	135	8	line	line	NOUN
cord-011435-x73foqu7	135	9	(	(	PUNCT
cord-011435-x73foqu7	135	10	a549	a549	PROPN
cord-011435-x73foqu7	135	11	)	)	PUNCT
cord-011435-x73foqu7	135	12	,	,	PUNCT
cord-011435-x73foqu7	135	13	in	in	ADP
cord-011435-x73foqu7	135	14	which	which	PRON
cord-011435-x73foqu7	135	15	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	135	16	also	also	ADV
cord-011435-x73foqu7	135	17	inhibited	inhibit	VERB
cord-011435-x73foqu7	135	18	vsv	vsv	PROPN
cord-011435-x73foqu7	135	19	-	-	PUNCT
cord-011435-x73foqu7	135	20	encoded	encode	VERB
cord-011435-x73foqu7	135	21	gfp	gfp	NOUN
cord-011435-x73foqu7	135	22	expression	expression	NOUN
cord-011435-x73foqu7	135	23	(	(	PUNCT
cord-011435-x73foqu7	135	24	figure	figure	NOUN
cord-011435-x73foqu7	135	25	3d	3d	NOUN
cord-011435-x73foqu7	135	26	)	)	PUNCT
cord-011435-x73foqu7	135	27	.	.	PUNCT
cord-011435-x73foqu7	136	1	to	to	PART
cord-011435-x73foqu7	136	2	determine	determine	VERB
cord-011435-x73foqu7	136	3	whether	whether	SCONJ
cord-011435-x73foqu7	136	4	the	the	DET
cord-011435-x73foqu7	136	5	antiviral	antiviral	ADJ
cord-011435-x73foqu7	136	6	activity	activity	NOUN
cord-011435-x73foqu7	136	7	of	of	ADP
cord-011435-x73foqu7	136	8	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	136	9	is	be	AUX
cord-011435-x73foqu7	136	10	dependent	dependent	ADJ
cord-011435-x73foqu7	136	11	on	on	ADP
cord-011435-x73foqu7	136	12	irf3	irf3	PROPN
cord-011435-x73foqu7	136	13	,	,	PUNCT
cord-011435-x73foqu7	136	14	we	we	PRON
cord-011435-x73foqu7	136	15	generated	generate	VERB
cord-011435-x73foqu7	136	16	irf3	irf3	PROPN
cord-011435-x73foqu7	136	17	−/−	−/−	PROPN
cord-011435-x73foqu7	136	18	human	human	ADJ
cord-011435-x73foqu7	136	19	cells	cell	NOUN
cord-011435-x73foqu7	136	20	(	(	PUNCT
cord-011435-x73foqu7	136	21	ht1080	ht1080	PROPN
cord-011435-x73foqu7	136	22	)	)	PUNCT
cord-011435-x73foqu7	136	23	using	use	VERB
cord-011435-x73foqu7	136	24	a	a	DET
cord-011435-x73foqu7	136	25	crispr	crispr	ADJ
cord-011435-x73foqu7	136	26	/	/	SYM
cord-011435-x73foqu7	136	27	cas9	cas9	NOUN
cord-011435-x73foqu7	136	28	approach	approach	NOUN
cord-011435-x73foqu7	136	29	(	(	PUNCT
cord-011435-x73foqu7	136	30	figure	figure	NOUN
cord-011435-x73foqu7	136	31	3e	3e	X
cord-011435-x73foqu7	136	32	,	,	PUNCT
cord-011435-x73foqu7	136	33	lower	low	ADJ
cord-011435-x73foqu7	136	34	panel	panel	NOUN
cord-011435-x73foqu7	136	35	,	,	PUNCT
cord-011435-x73foqu7	136	36	figure	figure	NOUN
cord-011435-x73foqu7	136	37	s2	s2	PROPN
cord-011435-x73foqu7	136	38	)	)	PUNCT
cord-011435-x73foqu7	136	39	.	.	PUNCT
cord-011435-x73foqu7	137	1	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	137	2	,	,	PUNCT
cord-011435-x73foqu7	137	3	as	as	SCONJ
cord-011435-x73foqu7	137	4	expected	expect	VERB
cord-011435-x73foqu7	137	5	,	,	PUNCT
cord-011435-x73foqu7	137	6	inhibited	inhibit	VERB
cord-011435-x73foqu7	137	7	the	the	DET
cord-011435-x73foqu7	137	8	viral	viral	ADJ
cord-011435-x73foqu7	137	9	protein	protein	NOUN
cord-011435-x73foqu7	137	10	expression	expression	NOUN
cord-011435-x73foqu7	137	11	in	in	ADP
cord-011435-x73foqu7	137	12	the	the	DET
cord-011435-x73foqu7	137	13	wt	wt	PROPN
cord-011435-x73foqu7	137	14	cells	cell	NOUN
cord-011435-x73foqu7	137	15	;	;	PUNCT
cord-011435-x73foqu7	137	16	however	however	ADV
cord-011435-x73foqu7	137	17	,	,	PUNCT
cord-011435-x73foqu7	137	18	the	the	DET
cord-011435-x73foqu7	137	19	antiviral	antiviral	ADJ
cord-011435-x73foqu7	137	20	activity	activity	NOUN
cord-011435-x73foqu7	137	21	of	of	ADP
cord-011435-x73foqu7	137	22	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	137	23	was	be	AUX
cord-011435-x73foqu7	137	24	impaired	impair	VERB
cord-011435-x73foqu7	137	25	in	in	ADP
cord-011435-x73foqu7	137	26	irf3	irf3	PROPN
cord-011435-x73foqu7	137	27	−/−	−/−	NUM
cord-011435-x73foqu7	137	28	cells	cell	NOUN
cord-011435-x73foqu7	137	29	(	(	PUNCT
cord-011435-x73foqu7	137	30	figure	figure	NOUN
cord-011435-x73foqu7	137	31	3e	3e	X
cord-011435-x73foqu7	137	32	,	,	PUNCT
cord-011435-x73foqu7	137	33	top	top	ADJ
cord-011435-x73foqu7	137	34	panel	panel	NOUN
cord-011435-x73foqu7	137	35	)	)	PUNCT
cord-011435-x73foqu7	137	36	.	.	PUNCT
cord-011435-x73foqu7	138	1	to	to	PART
cord-011435-x73foqu7	138	2	further	far	ADV
cord-011435-x73foqu7	138	3	validate	validate	VERB
cord-011435-x73foqu7	138	4	this	this	DET
cord-011435-x73foqu7	138	5	striking	striking	ADJ
cord-011435-x73foqu7	138	6	result	result	NOUN
cord-011435-x73foqu7	138	7	,	,	PUNCT
cord-011435-x73foqu7	138	8	we	we	PRON
cord-011435-x73foqu7	138	9	used	use	VERB
cord-011435-x73foqu7	138	10	wt	wt	PROPN
cord-011435-x73foqu7	138	11	and	and	CCONJ
cord-011435-x73foqu7	138	12	irf3	irf3	PROPN
cord-011435-x73foqu7	138	13	−/−	−/−	PRON
cord-011435-x73foqu7	138	14	mouse	mouse	NOUN
cord-011435-x73foqu7	138	15	embryonic	embryonic	NOUN
cord-011435-x73foqu7	138	16	fibroblasts	fibroblast	NOUN
cord-011435-x73foqu7	138	17	(	(	PUNCT
cord-011435-x73foqu7	138	18	mefs	mef	NOUN
cord-011435-x73foqu7	138	19	)	)	PUNCT
cord-011435-x73foqu7	138	20	(	(	PUNCT
cord-011435-x73foqu7	138	21	figure	figure	NOUN
cord-011435-x73foqu7	138	22	3f	3f	PROPN
cord-011435-x73foqu7	138	23	,	,	PUNCT
cord-011435-x73foqu7	138	24	lower	low	ADJ
cord-011435-x73foqu7	138	25	panel	panel	NOUN
cord-011435-x73foqu7	138	26	)	)	PUNCT
cord-011435-x73foqu7	138	27	.	.	PUNCT
cord-011435-x73foqu7	139	1	similar	similar	ADJ
cord-011435-x73foqu7	139	2	to	to	ADP
cord-011435-x73foqu7	139	3	the	the	DET
cord-011435-x73foqu7	139	4	human	human	ADJ
cord-011435-x73foqu7	139	5	cells	cell	NOUN
cord-011435-x73foqu7	139	6	,	,	PUNCT
cord-011435-x73foqu7	139	7	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	139	8	inhibited	inhibited	PROPN
cord-011435-x73foqu7	139	9	vsv	vsv	PROPN
cord-011435-x73foqu7	139	10	replication	replication	NOUN
cord-011435-x73foqu7	139	11	only	only	ADV
cord-011435-x73foqu7	139	12	in	in	ADP
cord-011435-x73foqu7	139	13	the	the	DET
cord-011435-x73foqu7	139	14	presence	presence	NOUN
cord-011435-x73foqu7	139	15	of	of	ADP
cord-011435-x73foqu7	139	16	irf3	irf3	PROPN
cord-011435-x73foqu7	139	17	(	(	PUNCT
cord-011435-x73foqu7	139	18	figure	figure	NOUN
cord-011435-x73foqu7	139	19	3f	3f	PROPN
cord-011435-x73foqu7	139	20	,	,	PUNCT
cord-011435-x73foqu7	139	21	top	top	ADJ
cord-011435-x73foqu7	139	22	panel	panel	NOUN
cord-011435-x73foqu7	139	23	)	)	PUNCT
cord-011435-x73foqu7	139	24	.	.	PUNCT
cord-011435-x73foqu7	140	1	we	we	PRON
cord-011435-x73foqu7	140	2	further	far	ADV
cord-011435-x73foqu7	140	3	quantified	quantify	VERB
cord-011435-x73foqu7	140	4	,	,	PUNCT
cord-011435-x73foqu7	140	5	in	in	ADP
cord-011435-x73foqu7	140	6	addition	addition	NOUN
cord-011435-x73foqu7	140	7	to	to	ADP
cord-011435-x73foqu7	140	8	viral	viral	ADJ
cord-011435-x73foqu7	140	9	g	g	PROPN
cord-011435-x73foqu7	140	10	protein	protein	NOUN
cord-011435-x73foqu7	140	11	,	,	PUNCT
cord-011435-x73foqu7	140	12	the	the	DET
cord-011435-x73foqu7	140	13	expression	expression	NOUN
cord-011435-x73foqu7	140	14	of	of	ADP
cord-011435-x73foqu7	140	15	vsv	vsv	PROPN
cord-011435-x73foqu7	140	16	-	-	PUNCT
cord-011435-x73foqu7	140	17	encoded	encode	VERB
cord-011435-x73foqu7	140	18	gfp	gfp	PROPN
cord-011435-x73foqu7	140	19	fluorescence	fluorescence	PROPN
cord-011435-x73foqu7	140	20	.	.	PUNCT
cord-011435-x73foqu7	141	1	similar	similar	ADJ
cord-011435-x73foqu7	141	2	to	to	ADP
cord-011435-x73foqu7	141	3	the	the	DET
cord-011435-x73foqu7	141	4	inhibition	inhibition	NOUN
cord-011435-x73foqu7	141	5	of	of	ADP
cord-011435-x73foqu7	141	6	g	g	NOUN
cord-011435-x73foqu7	141	7	protein	protein	NOUN
cord-011435-x73foqu7	141	8	expression	expression	NOUN
cord-011435-x73foqu7	141	9	,	,	PUNCT
cord-011435-x73foqu7	141	10	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	141	11	inhibited	inhibit	VERB
cord-011435-x73foqu7	141	12	gfp	gfp	PROPN
cord-011435-x73foqu7	141	13	fluorescence	fluorescence	PROPN
cord-011435-x73foqu7	141	14	in	in	ADP
cord-011435-x73foqu7	141	15	wt	wt	PROPN
cord-011435-x73foqu7	141	16	but	but	CCONJ
cord-011435-x73foqu7	141	17	not	not	PART
cord-011435-x73foqu7	141	18	irf3	irf3	NOUN
cord-011435-x73foqu7	141	19	-	-	PUNCT
cord-011435-x73foqu7	141	20	deficient	deficient	ADJ
cord-011435-x73foqu7	141	21	cells	cell	NOUN
cord-011435-x73foqu7	141	22	(	(	PUNCT
cord-011435-x73foqu7	141	23	figure	figure	NOUN
cord-011435-x73foqu7	141	24	3e	3e	PROPN
cord-011435-x73foqu7	141	25	,	,	PUNCT
cord-011435-x73foqu7	141	26	f	f	NUM
cord-011435-x73foqu7	141	27	)	)	PUNCT
cord-011435-x73foqu7	141	28	.	.	PUNCT
cord-011435-x73foqu7	142	1	we	we	PRON
cord-011435-x73foqu7	142	2	ensured	ensure	VERB
cord-011435-x73foqu7	142	3	that	that	SCONJ
cord-011435-x73foqu7	142	4	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	142	5	did	do	AUX
cord-011435-x73foqu7	142	6	not	not	PART
cord-011435-x73foqu7	142	7	cause	cause	VERB
cord-011435-x73foqu7	142	8	substantial	substantial	ADJ
cord-011435-x73foqu7	142	9	cytotoxicity	cytotoxicity	NOUN
cord-011435-x73foqu7	142	10	under	under	ADP
cord-011435-x73foqu7	142	11	our	our	PRON
cord-011435-x73foqu7	142	12	experimental	experimental	ADJ
cord-011435-x73foqu7	142	13	conditions	condition	NOUN
cord-011435-x73foqu7	142	14	(	(	PUNCT
cord-011435-x73foqu7	142	15	figure	figure	NOUN
cord-011435-x73foqu7	142	16	s3a	s3a	PROPN
cord-011435-x73foqu7	142	17	,	,	PUNCT
cord-011435-x73foqu7	142	18	b	b	PROPN
cord-011435-x73foqu7	142	19	)	)	PUNCT
cord-011435-x73foqu7	142	20	.	.	PUNCT
cord-011435-x73foqu7	143	1	our	our	PRON
cord-011435-x73foqu7	143	2	results	result	NOUN
cord-011435-x73foqu7	143	3	demonstrate	demonstrate	VERB
cord-011435-x73foqu7	143	4	,	,	PUNCT
cord-011435-x73foqu7	143	5	for	for	ADP
cord-011435-x73foqu7	143	6	the	the	DET
cord-011435-x73foqu7	143	7	first	first	ADJ
cord-011435-x73foqu7	143	8	time	time	NOUN
cord-011435-x73foqu7	143	9	,	,	PUNCT
cord-011435-x73foqu7	143	10	that	that	SCONJ
cord-011435-x73foqu7	143	11	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	143	12	is	be	AUX
cord-011435-x73foqu7	143	13	a	a	DET
cord-011435-x73foqu7	143	14	ripa	ripa	ADV
cord-011435-x73foqu7	143	15	-	-	PUNCT
cord-011435-x73foqu7	143	16	promoting	promote	VERB
cord-011435-x73foqu7	143	17	agent	agent	NOUN
cord-011435-x73foqu7	143	18	,	,	PUNCT
cord-011435-x73foqu7	143	19	which	which	PRON
cord-011435-x73foqu7	143	20	inhibits	inhibit	VERB
cord-011435-x73foqu7	143	21	viral	viral	ADJ
cord-011435-x73foqu7	143	22	infection	infection	NOUN
cord-011435-x73foqu7	143	23	in	in	ADP
cord-011435-x73foqu7	143	24	an	an	DET
cord-011435-x73foqu7	143	25	irf3	irf3	NOUN
cord-011435-x73foqu7	143	26	-	-	PUNCT
cord-011435-x73foqu7	143	27	dependent	dependent	ADJ
cord-011435-x73foqu7	143	28	manner	manner	NOUN
cord-011435-x73foqu7	143	29	.	.	PUNCT
cord-011435-x73foqu7	144	1	the	the	DET
cord-011435-x73foqu7	144	2	optimal	optimal	ADJ
cord-011435-x73foqu7	144	3	antiviral	antiviral	ADJ
cord-011435-x73foqu7	144	4	action	action	NOUN
cord-011435-x73foqu7	144	5	of	of	ADP
cord-011435-x73foqu7	144	6	irf3	irf3	PROPN
cord-011435-x73foqu7	144	7	depends	depend	VERB
cord-011435-x73foqu7	144	8	on	on	ADP
cord-011435-x73foqu7	144	9	its	its	PRON
cord-011435-x73foqu7	144	10	transcriptional	transcriptional	NOUN
cord-011435-x73foqu7	144	11	and	and	CCONJ
cord-011435-x73foqu7	144	12	nontranscriptional	nontranscriptional	ADJ
cord-011435-x73foqu7	144	13	(	(	PUNCT
cord-011435-x73foqu7	144	14	nt	not	PART
cord-011435-x73foqu7	144	15	,	,	PUNCT
cord-011435-x73foqu7	144	16	ripa	ripa	PROPN
cord-011435-x73foqu7	144	17	)	)	PUNCT
cord-011435-x73foqu7	144	18	functions	function	NOUN
cord-011435-x73foqu7	144	19	.	.	PUNCT
cord-011435-x73foqu7	145	1	we	we	PRON
cord-011435-x73foqu7	145	2	sought	seek	VERB
cord-011435-x73foqu7	145	3	to	to	PART
cord-011435-x73foqu7	145	4	determine	determine	VERB
cord-011435-x73foqu7	145	5	whether	whether	SCONJ
cord-011435-x73foqu7	145	6	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	145	7	activates	activate	VERB
cord-011435-x73foqu7	145	8	either	either	PRON
cord-011435-x73foqu7	145	9	one	one	NUM
cord-011435-x73foqu7	145	10	or	or	CCONJ
cord-011435-x73foqu7	145	11	both	both	DET
cord-011435-x73foqu7	145	12	functions	function	NOUN
cord-011435-x73foqu7	145	13	of	of	ADP
cord-011435-x73foqu7	145	14	irf3	irf3	PROPN
cord-011435-x73foqu7	145	15	.	.	PUNCT
cord-011435-x73foqu7	146	1	furthermore	furthermore	ADV
cord-011435-x73foqu7	146	2	,	,	PUNCT
cord-011435-x73foqu7	146	3	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	146	4	has	have	AUX
cord-011435-x73foqu7	146	5	previously	previously	ADV
cord-011435-x73foqu7	146	6	been	be	AUX
cord-011435-x73foqu7	146	7	reported	report	VERB
cord-011435-x73foqu7	146	8	to	to	PART
cord-011435-x73foqu7	146	9	induce	induce	VERB
cord-011435-x73foqu7	146	10	phosphorylation	phosphorylation	NOUN
cord-011435-x73foqu7	146	11	and	and	CCONJ
cord-011435-x73foqu7	146	12	transcriptional	transcriptional	NOUN
cord-011435-x73foqu7	146	13	activation	activation	NOUN
cord-011435-x73foqu7	146	14	of	of	ADP
cord-011435-x73foqu7	146	15	irf3	irf3	PROPN
cord-011435-x73foqu7	146	16	[	[	PUNCT
cord-011435-x73foqu7	146	17	28	28	NUM
cord-011435-x73foqu7	146	18	]	]	PUNCT
cord-011435-x73foqu7	146	19	.	.	PUNCT
cord-011435-x73foqu7	147	1	thus	thus	ADV
cord-011435-x73foqu7	147	2	,	,	PUNCT
cord-011435-x73foqu7	147	3	we	we	PRON
cord-011435-x73foqu7	147	4	examined	examine	VERB
cord-011435-x73foqu7	147	5	whether	whether	SCONJ
cord-011435-x73foqu7	147	6	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	147	7	promotes	promote	VERB
cord-011435-x73foqu7	147	8	the	the	DET
cord-011435-x73foqu7	147	9	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	147	10	activity	activity	NOUN
cord-011435-x73foqu7	147	11	of	of	ADP
cord-011435-x73foqu7	147	12	irf3	irf3	PROPN
cord-011435-x73foqu7	147	13	by	by	ADP
cord-011435-x73foqu7	147	14	rlr	rlr	NOUN
cord-011435-x73foqu7	147	15	-	-	PUNCT
cord-011435-x73foqu7	147	16	signaling	signaling	NOUN
cord-011435-x73foqu7	147	17	in	in	ADP
cord-011435-x73foqu7	147	18	vsv	vsv	PROPN
cord-011435-x73foqu7	147	19	-	-	PUNCT
cord-011435-x73foqu7	147	20	infected	infect	VERB
cord-011435-x73foqu7	147	21	cells	cell	NOUN
cord-011435-x73foqu7	147	22	.	.	PUNCT
cord-011435-x73foqu7	148	1	vsv	vsv	PROPN
cord-011435-x73foqu7	148	2	infection	infection	NOUN
cord-011435-x73foqu7	148	3	induced	induce	VERB
cord-011435-x73foqu7	148	4	irf3target	irf3target	PROPN
cord-011435-x73foqu7	148	5	gene	gene	NOUN
cord-011435-x73foqu7	148	6	,	,	PUNCT
cord-011435-x73foqu7	148	7	ifit3	ifit3	PROPN
cord-011435-x73foqu7	148	8	,	,	PUNCT
cord-011435-x73foqu7	148	9	which	which	PRON
cord-011435-x73foqu7	148	10	was	be	AUX
cord-011435-x73foqu7	148	11	strongly	strongly	ADV
cord-011435-x73foqu7	148	12	inhibited	inhibit	VERB
cord-011435-x73foqu7	148	13	by	by	ADP
cord-011435-x73foqu7	148	14	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	148	15	,	,	PUNCT
cord-011435-x73foqu7	148	16	examined	examine	VERB
cord-011435-x73foqu7	148	17	at	at	ADP
cord-011435-x73foqu7	148	18	multiple	multiple	ADJ
cord-011435-x73foqu7	148	19	doses	dose	NOUN
cord-011435-x73foqu7	148	20	(	(	PUNCT
cord-011435-x73foqu7	148	21	figure	figure	NOUN
cord-011435-x73foqu7	148	22	4a	4a	NUM
cord-011435-x73foqu7	148	23	)	)	PUNCT
cord-011435-x73foqu7	148	24	.	.	PUNCT
cord-011435-x73foqu7	149	1	in	in	ADP
cord-011435-x73foqu7	149	2	contrast	contrast	NOUN
cord-011435-x73foqu7	149	3	,	,	PUNCT
cord-011435-x73foqu7	149	4	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	149	5	robustly	robustly	ADV
cord-011435-x73foqu7	149	6	enhanced	enhance	VERB
cord-011435-x73foqu7	149	7	the	the	DET
cord-011435-x73foqu7	149	8	ripa	ripa	ADJ
cord-011435-x73foqu7	149	9	activity	activity	NOUN
cord-011435-x73foqu7	149	10	,	,	PUNCT
cord-011435-x73foqu7	149	11	i.e.	i.e.	X
cord-011435-x73foqu7	149	12	,	,	PUNCT
cord-011435-x73foqu7	149	13	the	the	DET
cord-011435-x73foqu7	149	14	c	c	ADJ
cord-011435-x73foqu7	149	15	-	-	PUNCT
cord-011435-x73foqu7	149	16	parp	parp	NOUN
cord-011435-x73foqu7	149	17	levels	level	NOUN
cord-011435-x73foqu7	149	18	in	in	ADP
cord-011435-x73foqu7	149	19	vsvinfected	vsvinfected	ADJ
cord-011435-x73foqu7	149	20	cells	cell	NOUN
cord-011435-x73foqu7	149	21	(	(	PUNCT
cord-011435-x73foqu7	149	22	figure	figure	NOUN
cord-011435-x73foqu7	149	23	4a	4a	NUM
cord-011435-x73foqu7	149	24	)	)	PUNCT
cord-011435-x73foqu7	149	25	.	.	PUNCT
cord-011435-x73foqu7	150	1	to	to	PART
cord-011435-x73foqu7	150	2	solidify	solidify	VERB
cord-011435-x73foqu7	150	3	these	these	DET
cord-011435-x73foqu7	150	4	results	result	NOUN
cord-011435-x73foqu7	150	5	,	,	PUNCT
cord-011435-x73foqu7	150	6	we	we	PRON
cord-011435-x73foqu7	150	7	used	use	VERB
cord-011435-x73foqu7	150	8	a	a	DET
cord-011435-x73foqu7	150	9	nonviral	nonviral	ADJ
cord-011435-x73foqu7	150	10	rlr	rlr	NOUN
cord-011435-x73foqu7	150	11	agonist	agonist	NOUN
cord-011435-x73foqu7	150	12	,	,	PUNCT
cord-011435-x73foqu7	150	13	polyi	polyi	NOUN
cord-011435-x73foqu7	150	14	:	:	PUNCT
cord-011435-x73foqu7	150	15	c	c	X
cord-011435-x73foqu7	150	16	,	,	PUNCT
cord-011435-x73foqu7	150	17	and	and	CCONJ
cord-011435-x73foqu7	150	18	the	the	DET
cord-011435-x73foqu7	150	19	irf3	irf3	PROPN
cord-011435-x73foqu7	150	20	-	-	PUNCT
cord-011435-x73foqu7	150	21	induced	induce	VERB
cord-011435-x73foqu7	150	22	ifit3	ifit3	PROPN
cord-011435-x73foqu7	150	23	was	be	AUX
cord-011435-x73foqu7	150	24	also	also	ADV
cord-011435-x73foqu7	150	25	strongly	strongly	ADV
cord-011435-x73foqu7	150	26	inhibited	inhibit	VERB
cord-011435-x73foqu7	150	27	by	by	ADP
cord-011435-x73foqu7	150	28	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	150	29	in	in	ADP
cord-011435-x73foqu7	150	30	ht1080	ht1080	PROPN
cord-011435-x73foqu7	150	31	cells	cell	NOUN
cord-011435-x73foqu7	150	32	(	(	PUNCT
cord-011435-x73foqu7	150	33	figure	figure	NOUN
cord-011435-x73foqu7	150	34	4b	4b	PROPN
cord-011435-x73foqu7	150	35	)	)	PUNCT
cord-011435-x73foqu7	150	36	.	.	PUNCT
cord-011435-x73foqu7	151	1	similar	similar	ADJ
cord-011435-x73foqu7	151	2	to	to	ADP
cord-011435-x73foqu7	151	3	vsv	vsv	NOUN
cord-011435-x73foqu7	151	4	-	-	PUNCT
cord-011435-x73foqu7	151	5	infected	infect	VERB
cord-011435-x73foqu7	151	6	cells	cell	NOUN
cord-011435-x73foqu7	151	7	,	,	PUNCT
cord-011435-x73foqu7	151	8	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	151	9	promoted	promote	VERB
cord-011435-x73foqu7	151	10	irf3	irf3	PROPN
cord-011435-x73foqu7	151	11	-	-	PUNCT
cord-011435-x73foqu7	151	12	induced	induce	VERB
cord-011435-x73foqu7	151	13	ripa	ripa	ADJ
cord-011435-x73foqu7	151	14	activity	activity	NOUN
cord-011435-x73foqu7	151	15	in	in	ADP
cord-011435-x73foqu7	151	16	these	these	DET
cord-011435-x73foqu7	151	17	cells	cell	NOUN
cord-011435-x73foqu7	151	18	(	(	PUNCT
cord-011435-x73foqu7	151	19	c	c	NOUN
cord-011435-x73foqu7	151	20	-	-	NOUN
cord-011435-x73foqu7	151	21	parp	parp	ADJ
cord-011435-x73foqu7	151	22	,	,	PUNCT
cord-011435-x73foqu7	151	23	figure	figure	NOUN
cord-011435-x73foqu7	151	24	4b	4b	PROPN
cord-011435-x73foqu7	151	25	)	)	PUNCT
cord-011435-x73foqu7	151	26	.	.	PUNCT
cord-011435-x73foqu7	152	1	to	to	PART
cord-011435-x73foqu7	152	2	validate	validate	VERB
cord-011435-x73foqu7	152	3	these	these	DET
cord-011435-x73foqu7	152	4	results	result	NOUN
cord-011435-x73foqu7	152	5	,	,	PUNCT
cord-011435-x73foqu7	152	6	we	we	PRON
cord-011435-x73foqu7	152	7	measured	measure	VERB
cord-011435-x73foqu7	152	8	the	the	DET
cord-011435-x73foqu7	152	9	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	152	10	induction	induction	NOUN
cord-011435-x73foqu7	152	11	of	of	ADP
cord-011435-x73foqu7	152	12	additional	additional	ADJ
cord-011435-x73foqu7	152	13	irf3induced	irf3induced	PROPN
cord-011435-x73foqu7	152	14	genes	gene	NOUN
cord-011435-x73foqu7	152	15	,	,	PUNCT
cord-011435-x73foqu7	152	16	both	both	PRON
cord-011435-x73foqu7	152	17	at	at	ADP
cord-011435-x73foqu7	152	18	the	the	DET
cord-011435-x73foqu7	152	19	protein	protein	NOUN
cord-011435-x73foqu7	152	20	and	and	CCONJ
cord-011435-x73foqu7	152	21	mrna	mrna	NOUN
cord-011435-x73foqu7	152	22	levels	level	NOUN
cord-011435-x73foqu7	152	23	.	.	PUNCT
cord-011435-x73foqu7	153	1	the	the	DET
cord-011435-x73foqu7	153	2	irf3	irf3	PROPN
cord-011435-x73foqu7	153	3	-	-	PUNCT
cord-011435-x73foqu7	153	4	induced	induce	VERB
cord-011435-x73foqu7	153	5	ifit3	ifit3	NOUN
cord-011435-x73foqu7	153	6	and	and	CCONJ
cord-011435-x73foqu7	153	7	ifit1	ifit1	NOUN
cord-011435-x73foqu7	153	8	proteins	protein	NOUN
cord-011435-x73foqu7	153	9	were	be	AUX
cord-011435-x73foqu7	153	10	strongly	strongly	ADV
cord-011435-x73foqu7	153	11	inhibited	inhibit	VERB
cord-011435-x73foqu7	153	12	by	by	ADP
cord-011435-x73foqu7	153	13	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	153	14	at	at	ADP
cord-011435-x73foqu7	153	15	multiple	multiple	ADJ
cord-011435-x73foqu7	153	16	times	time	NOUN
cord-011435-x73foqu7	153	17	post	post	X
cord-011435-x73foqu7	153	18	rlr	rlr	NOUN
cord-011435-x73foqu7	153	19	-	-	PUNCT
cord-011435-x73foqu7	153	20	stimulation	stimulation	NOUN
cord-011435-x73foqu7	153	21	(	(	PUNCT
cord-011435-x73foqu7	153	22	figure	figure	NOUN
cord-011435-x73foqu7	153	23	4c	4c	NUM
cord-011435-x73foqu7	153	24	)	)	PUNCT
cord-011435-x73foqu7	153	25	.	.	PUNCT
cord-011435-x73foqu7	154	1	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	154	2	treatment	treatment	PROPN
cord-011435-x73foqu7	154	3	also	also	ADV
cord-011435-x73foqu7	154	4	significantly	significantly	ADV
cord-011435-x73foqu7	154	5	inhibited	inhibit	VERB
cord-011435-x73foqu7	154	6	the	the	DET
cord-011435-x73foqu7	154	7	mrna	mrna	NOUN
cord-011435-x73foqu7	154	8	induction	induction	NOUN
cord-011435-x73foqu7	154	9	of	of	ADP
cord-011435-x73foqu7	154	10	ifit3	ifit3	PROPN
cord-011435-x73foqu7	154	11	(	(	PUNCT
cord-011435-x73foqu7	154	12	figure	figure	NOUN
cord-011435-x73foqu7	154	13	4d	4d	PROPN
cord-011435-x73foqu7	154	14	)	)	PUNCT
cord-011435-x73foqu7	154	15	,	,	PUNCT
cord-011435-x73foqu7	154	16	ifit1	ifit1	PROPN
cord-011435-x73foqu7	154	17	(	(	PUNCT
cord-011435-x73foqu7	154	18	figure	figure	NOUN
cord-011435-x73foqu7	154	19	4e	4e	PROPN
cord-011435-x73foqu7	154	20	)	)	PUNCT
cord-011435-x73foqu7	154	21	,	,	PUNCT
cord-011435-x73foqu7	154	22	and	and	CCONJ
cord-011435-x73foqu7	154	23	ifn	ifn	NOUN
cord-011435-x73foqu7	154	24	-	-	PUNCT
cord-011435-x73foqu7	154	25	β	β	NOUN
cord-011435-x73foqu7	154	26	(	(	PUNCT
cord-011435-x73foqu7	154	27	figure	figure	NOUN
cord-011435-x73foqu7	154	28	4f	4f	NUM
cord-011435-x73foqu7	154	29	)	)	PUNCT
cord-011435-x73foqu7	154	30	,	,	PUNCT
cord-011435-x73foqu7	154	31	all	all	PRON
cord-011435-x73foqu7	154	32	of	of	ADP
cord-011435-x73foqu7	154	33	which	which	PRON
cord-011435-x73foqu7	154	34	depend	depend	VERB
cord-011435-x73foqu7	154	35	on	on	ADP
cord-011435-x73foqu7	154	36	the	the	DET
cord-011435-x73foqu7	154	37	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	154	38	activity	activity	NOUN
cord-011435-x73foqu7	154	39	of	of	ADP
cord-011435-x73foqu7	154	40	irf3	irf3	PROPN
cord-011435-x73foqu7	154	41	.	.	PUNCT
cord-011435-x73foqu7	155	1	collectively	collectively	ADV
cord-011435-x73foqu7	155	2	,	,	PUNCT
cord-011435-x73foqu7	155	3	our	our	PRON
cord-011435-x73foqu7	155	4	results	result	NOUN
cord-011435-x73foqu7	155	5	demonstrate	demonstrate	VERB
cord-011435-x73foqu7	155	6	that	that	SCONJ
cord-011435-x73foqu7	155	7	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	155	8	inhibits	inhibit	VERB
cord-011435-x73foqu7	155	9	vsv	vsv	X
cord-011435-x73foqu7	155	10	replication	replication	NOUN
cord-011435-x73foqu7	155	11	in	in	ADP
cord-011435-x73foqu7	155	12	the	the	DET
cord-011435-x73foqu7	155	13	absence	absence	NOUN
cord-011435-x73foqu7	155	14	of	of	ADP
cord-011435-x73foqu7	155	15	irf3induced	irf3induced	ADJ
cord-011435-x73foqu7	155	16	antiviral	antiviral	ADJ
cord-011435-x73foqu7	155	17	gene	gene	NOUN
cord-011435-x73foqu7	155	18	expression	expression	NOUN
cord-011435-x73foqu7	155	19	.	.	PUNCT
cord-011435-x73foqu7	156	1	the	the	DET
cord-011435-x73foqu7	156	2	optimal	optimal	ADJ
cord-011435-x73foqu7	156	3	antiviral	antiviral	ADJ
cord-011435-x73foqu7	156	4	action	action	NOUN
cord-011435-x73foqu7	156	5	of	of	ADP
cord-011435-x73foqu7	156	6	irf3	irf3	PROPN
cord-011435-x73foqu7	156	7	depends	depend	VERB
cord-011435-x73foqu7	156	8	on	on	ADP
cord-011435-x73foqu7	156	9	its	its	PRON
cord-011435-x73foqu7	156	10	transcriptional	transcriptional	NOUN
cord-011435-x73foqu7	156	11	and	and	CCONJ
cord-011435-x73foqu7	156	12	nontranscriptional	nontranscriptional	ADJ
cord-011435-x73foqu7	156	13	(	(	PUNCT
cord-011435-x73foqu7	156	14	nt	not	PART
cord-011435-x73foqu7	156	15	,	,	PUNCT
cord-011435-x73foqu7	156	16	ripa	ripa	PROPN
cord-011435-x73foqu7	156	17	)	)	PUNCT
cord-011435-x73foqu7	156	18	functions	function	NOUN
cord-011435-x73foqu7	156	19	.	.	PUNCT
cord-011435-x73foqu7	157	1	we	we	PRON
cord-011435-x73foqu7	157	2	sought	seek	VERB
cord-011435-x73foqu7	157	3	to	to	PART
cord-011435-x73foqu7	157	4	determine	determine	VERB
cord-011435-x73foqu7	157	5	whether	whether	SCONJ
cord-011435-x73foqu7	157	6	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	157	7	activates	activate	VERB
cord-011435-x73foqu7	157	8	either	either	PRON
cord-011435-x73foqu7	157	9	one	one	NUM
cord-011435-x73foqu7	157	10	or	or	CCONJ
cord-011435-x73foqu7	157	11	both	both	DET
cord-011435-x73foqu7	157	12	functions	function	NOUN
cord-011435-x73foqu7	157	13	of	of	ADP
cord-011435-x73foqu7	157	14	irf3	irf3	PROPN
cord-011435-x73foqu7	157	15	.	.	PUNCT
cord-011435-x73foqu7	158	1	furthermore	furthermore	ADV
cord-011435-x73foqu7	158	2	,	,	PUNCT
cord-011435-x73foqu7	158	3	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	158	4	has	have	AUX
cord-011435-x73foqu7	158	5	previously	previously	ADV
cord-011435-x73foqu7	158	6	been	be	AUX
cord-011435-x73foqu7	158	7	reported	report	VERB
cord-011435-x73foqu7	158	8	to	to	PART
cord-011435-x73foqu7	158	9	induce	induce	VERB
cord-011435-x73foqu7	158	10	phosphorylation	phosphorylation	NOUN
cord-011435-x73foqu7	158	11	and	and	CCONJ
cord-011435-x73foqu7	158	12	transcriptional	transcriptional	NOUN
cord-011435-x73foqu7	158	13	activation	activation	NOUN
cord-011435-x73foqu7	158	14	of	of	ADP
cord-011435-x73foqu7	158	15	irf3	irf3	PROPN
cord-011435-x73foqu7	158	16	[	[	PUNCT
cord-011435-x73foqu7	158	17	28	28	NUM
cord-011435-x73foqu7	158	18	]	]	PUNCT
cord-011435-x73foqu7	158	19	.	.	PUNCT
cord-011435-x73foqu7	159	1	thus	thus	ADV
cord-011435-x73foqu7	159	2	,	,	PUNCT
cord-011435-x73foqu7	159	3	we	we	PRON
cord-011435-x73foqu7	159	4	examined	examine	VERB
cord-011435-x73foqu7	159	5	whether	whether	SCONJ
cord-011435-x73foqu7	159	6	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	159	7	promotes	promote	VERB
cord-011435-x73foqu7	159	8	the	the	DET
cord-011435-x73foqu7	159	9	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	159	10	activity	activity	NOUN
cord-011435-x73foqu7	159	11	of	of	ADP
cord-011435-x73foqu7	159	12	irf3	irf3	PROPN
cord-011435-x73foqu7	159	13	by	by	ADP
cord-011435-x73foqu7	159	14	rlr	rlr	NOUN
cord-011435-x73foqu7	159	15	-	-	PUNCT
cord-011435-x73foqu7	159	16	signaling	signaling	NOUN
cord-011435-x73foqu7	159	17	in	in	ADP
cord-011435-x73foqu7	159	18	vsv	vsv	PROPN
cord-011435-x73foqu7	159	19	-	-	PUNCT
cord-011435-x73foqu7	159	20	infected	infect	VERB
cord-011435-x73foqu7	159	21	cells	cell	NOUN
cord-011435-x73foqu7	159	22	.	.	PUNCT
cord-011435-x73foqu7	160	1	vsv	vsv	PROPN
cord-011435-x73foqu7	160	2	infection	infection	NOUN
cord-011435-x73foqu7	160	3	induced	induce	VERB
cord-011435-x73foqu7	160	4	irf3	irf3	PROPN
cord-011435-x73foqu7	160	5	-	-	PUNCT
cord-011435-x73foqu7	160	6	target	target	NOUN
cord-011435-x73foqu7	160	7	gene	gene	NOUN
cord-011435-x73foqu7	160	8	,	,	PUNCT
cord-011435-x73foqu7	160	9	ifit3	ifit3	PROPN
cord-011435-x73foqu7	160	10	,	,	PUNCT
cord-011435-x73foqu7	160	11	which	which	PRON
cord-011435-x73foqu7	160	12	was	be	AUX
cord-011435-x73foqu7	160	13	strongly	strongly	ADV
cord-011435-x73foqu7	160	14	inhibited	inhibit	VERB
cord-011435-x73foqu7	160	15	by	by	ADP
cord-011435-x73foqu7	160	16	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	160	17	,	,	PUNCT
cord-011435-x73foqu7	160	18	examined	examine	VERB
cord-011435-x73foqu7	160	19	at	at	ADP
cord-011435-x73foqu7	160	20	multiple	multiple	ADJ
cord-011435-x73foqu7	160	21	doses	dose	NOUN
cord-011435-x73foqu7	160	22	(	(	PUNCT
cord-011435-x73foqu7	160	23	figure	figure	NOUN
cord-011435-x73foqu7	160	24	4a	4a	NUM
cord-011435-x73foqu7	160	25	)	)	PUNCT
cord-011435-x73foqu7	160	26	.	.	PUNCT
cord-011435-x73foqu7	161	1	in	in	ADP
cord-011435-x73foqu7	161	2	contrast	contrast	NOUN
cord-011435-x73foqu7	161	3	,	,	PUNCT
cord-011435-x73foqu7	161	4	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	161	5	robustly	robustly	ADV
cord-011435-x73foqu7	161	6	enhanced	enhance	VERB
cord-011435-x73foqu7	161	7	the	the	DET
cord-011435-x73foqu7	161	8	ripa	ripa	ADJ
cord-011435-x73foqu7	161	9	activity	activity	NOUN
cord-011435-x73foqu7	161	10	,	,	PUNCT
cord-011435-x73foqu7	161	11	i.e.	i.e.	X
cord-011435-x73foqu7	161	12	,	,	PUNCT
cord-011435-x73foqu7	161	13	the	the	DET
cord-011435-x73foqu7	161	14	c	c	ADJ
cord-011435-x73foqu7	161	15	-	-	PUNCT
cord-011435-x73foqu7	161	16	parp	parp	NOUN
cord-011435-x73foqu7	161	17	levels	level	NOUN
cord-011435-x73foqu7	161	18	in	in	ADP
cord-011435-x73foqu7	161	19	vsv	vsv	PROPN
cord-011435-x73foqu7	161	20	-	-	PUNCT
cord-011435-x73foqu7	161	21	infected	infect	VERB
cord-011435-x73foqu7	161	22	cells	cell	NOUN
cord-011435-x73foqu7	161	23	(	(	PUNCT
cord-011435-x73foqu7	161	24	figure	figure	NOUN
cord-011435-x73foqu7	161	25	4a	4a	NUM
cord-011435-x73foqu7	161	26	)	)	PUNCT
cord-011435-x73foqu7	161	27	.	.	PUNCT
cord-011435-x73foqu7	162	1	to	to	PART
cord-011435-x73foqu7	162	2	solidify	solidify	VERB
cord-011435-x73foqu7	162	3	these	these	DET
cord-011435-x73foqu7	162	4	results	result	NOUN
cord-011435-x73foqu7	162	5	,	,	PUNCT
cord-011435-x73foqu7	162	6	we	we	PRON
cord-011435-x73foqu7	162	7	used	use	VERB
cord-011435-x73foqu7	162	8	a	a	DET
cord-011435-x73foqu7	162	9	nonviral	nonviral	ADJ
cord-011435-x73foqu7	162	10	rlr	rlr	NOUN
cord-011435-x73foqu7	162	11	agonist	agonist	NOUN
cord-011435-x73foqu7	162	12	,	,	PUNCT
cord-011435-x73foqu7	162	13	polyi	polyi	NOUN
cord-011435-x73foqu7	162	14	:	:	PUNCT
cord-011435-x73foqu7	162	15	c	c	X
cord-011435-x73foqu7	162	16	,	,	PUNCT
cord-011435-x73foqu7	162	17	and	and	CCONJ
cord-011435-x73foqu7	162	18	the	the	DET
cord-011435-x73foqu7	162	19	irf3	irf3	PROPN
cord-011435-x73foqu7	162	20	-	-	PUNCT
cord-011435-x73foqu7	162	21	induced	induce	VERB
cord-011435-x73foqu7	162	22	ifit3	ifit3	PROPN
cord-011435-x73foqu7	162	23	was	be	AUX
cord-011435-x73foqu7	162	24	also	also	ADV
cord-011435-x73foqu7	162	25	strongly	strongly	ADV
cord-011435-x73foqu7	162	26	inhibited	inhibit	VERB
cord-011435-x73foqu7	162	27	by	by	ADP
cord-011435-x73foqu7	162	28	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	162	29	in	in	ADP
cord-011435-x73foqu7	162	30	ht1080	ht1080	PROPN
cord-011435-x73foqu7	162	31	cells	cell	NOUN
cord-011435-x73foqu7	162	32	(	(	PUNCT
cord-011435-x73foqu7	162	33	figure	figure	NOUN
cord-011435-x73foqu7	162	34	4b	4b	PROPN
cord-011435-x73foqu7	162	35	)	)	PUNCT
cord-011435-x73foqu7	162	36	.	.	PUNCT
cord-011435-x73foqu7	163	1	similar	similar	ADJ
cord-011435-x73foqu7	163	2	to	to	ADP
cord-011435-x73foqu7	163	3	vsv	vsv	NOUN
cord-011435-x73foqu7	163	4	-	-	PUNCT
cord-011435-x73foqu7	163	5	infected	infect	VERB
cord-011435-x73foqu7	163	6	cells	cell	NOUN
cord-011435-x73foqu7	163	7	,	,	PUNCT
cord-011435-x73foqu7	163	8	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	163	9	promoted	promote	VERB
cord-011435-x73foqu7	163	10	irf3	irf3	PROPN
cord-011435-x73foqu7	163	11	-	-	PUNCT
cord-011435-x73foqu7	163	12	induced	induce	VERB
cord-011435-x73foqu7	163	13	ripa	ripa	ADJ
cord-011435-x73foqu7	163	14	activity	activity	NOUN
cord-011435-x73foqu7	163	15	in	in	ADP
cord-011435-x73foqu7	163	16	these	these	DET
cord-011435-x73foqu7	163	17	cells	cell	NOUN
cord-011435-x73foqu7	163	18	(	(	PUNCT
cord-011435-x73foqu7	163	19	c	c	NOUN
cord-011435-x73foqu7	163	20	-	-	NOUN
cord-011435-x73foqu7	163	21	parp	parp	ADJ
cord-011435-x73foqu7	163	22	,	,	PUNCT
cord-011435-x73foqu7	163	23	figure	figure	NOUN
cord-011435-x73foqu7	163	24	4b	4b	PROPN
cord-011435-x73foqu7	163	25	)	)	PUNCT
cord-011435-x73foqu7	163	26	.	.	PUNCT
cord-011435-x73foqu7	164	1	to	to	PART
cord-011435-x73foqu7	164	2	validate	validate	VERB
cord-011435-x73foqu7	164	3	these	these	DET
cord-011435-x73foqu7	164	4	results	result	NOUN
cord-011435-x73foqu7	164	5	,	,	PUNCT
cord-011435-x73foqu7	164	6	we	we	PRON
cord-011435-x73foqu7	164	7	measured	measure	VERB
cord-011435-x73foqu7	164	8	the	the	DET
cord-011435-x73foqu7	164	9	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	164	10	induction	induction	NOUN
cord-011435-x73foqu7	164	11	of	of	ADP
cord-011435-x73foqu7	164	12	additional	additional	ADJ
cord-011435-x73foqu7	164	13	irf3	irf3	PROPN
cord-011435-x73foqu7	164	14	-	-	PUNCT
cord-011435-x73foqu7	164	15	induced	induce	VERB
cord-011435-x73foqu7	164	16	genes	gene	NOUN
cord-011435-x73foqu7	164	17	,	,	PUNCT
cord-011435-x73foqu7	164	18	both	both	PRON
cord-011435-x73foqu7	164	19	at	at	ADP
cord-011435-x73foqu7	164	20	the	the	DET
cord-011435-x73foqu7	164	21	protein	protein	NOUN
cord-011435-x73foqu7	164	22	and	and	CCONJ
cord-011435-x73foqu7	164	23	mrna	mrna	NOUN
cord-011435-x73foqu7	164	24	levels	level	NOUN
cord-011435-x73foqu7	164	25	.	.	PUNCT
cord-011435-x73foqu7	165	1	the	the	DET
cord-011435-x73foqu7	165	2	irf3	irf3	PROPN
cord-011435-x73foqu7	165	3	-	-	PUNCT
cord-011435-x73foqu7	165	4	induced	induce	VERB
cord-011435-x73foqu7	165	5	ifit3	ifit3	NOUN
cord-011435-x73foqu7	165	6	and	and	CCONJ
cord-011435-x73foqu7	165	7	ifit1	ifit1	NOUN
cord-011435-x73foqu7	165	8	proteins	protein	NOUN
cord-011435-x73foqu7	165	9	were	be	AUX
cord-011435-x73foqu7	165	10	strongly	strongly	ADV
cord-011435-x73foqu7	165	11	inhibited	inhibit	VERB
cord-011435-x73foqu7	165	12	by	by	ADP
cord-011435-x73foqu7	165	13	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	165	14	at	at	ADP
cord-011435-x73foqu7	165	15	multiple	multiple	ADJ
cord-011435-x73foqu7	165	16	times	time	NOUN
cord-011435-x73foqu7	165	17	post	post	X
cord-011435-x73foqu7	165	18	rlr	rlr	NOUN
cord-011435-x73foqu7	165	19	-	-	PUNCT
cord-011435-x73foqu7	165	20	stimulation	stimulation	NOUN
cord-011435-x73foqu7	165	21	(	(	PUNCT
cord-011435-x73foqu7	165	22	figure	figure	NOUN
cord-011435-x73foqu7	165	23	4c	4c	NUM
cord-011435-x73foqu7	165	24	)	)	PUNCT
cord-011435-x73foqu7	165	25	.	.	PUNCT
cord-011435-x73foqu7	166	1	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	166	2	treatment	treatment	PROPN
cord-011435-x73foqu7	166	3	also	also	ADV
cord-011435-x73foqu7	166	4	significantly	significantly	ADV
cord-011435-x73foqu7	166	5	inhibited	inhibit	VERB
cord-011435-x73foqu7	166	6	the	the	DET
cord-011435-x73foqu7	166	7	mrna	mrna	NOUN
cord-011435-x73foqu7	166	8	induction	induction	NOUN
cord-011435-x73foqu7	166	9	of	of	ADP
cord-011435-x73foqu7	166	10	ifit3	ifit3	PROPN
cord-011435-x73foqu7	166	11	(	(	PUNCT
cord-011435-x73foqu7	166	12	figure	figure	NOUN
cord-011435-x73foqu7	166	13	4d	4d	PROPN
cord-011435-x73foqu7	166	14	)	)	PUNCT
cord-011435-x73foqu7	166	15	,	,	PUNCT
cord-011435-x73foqu7	166	16	ifit1	ifit1	PROPN
cord-011435-x73foqu7	166	17	(	(	PUNCT
cord-011435-x73foqu7	166	18	figure	figure	NOUN
cord-011435-x73foqu7	166	19	4e	4e	PROPN
cord-011435-x73foqu7	166	20	)	)	PUNCT
cord-011435-x73foqu7	166	21	,	,	PUNCT
cord-011435-x73foqu7	166	22	and	and	CCONJ
cord-011435-x73foqu7	166	23	ifn	ifn	NOUN
cord-011435-x73foqu7	166	24	-	-	PUNCT
cord-011435-x73foqu7	166	25	β	β	NOUN
cord-011435-x73foqu7	167	1	(	(	PUNCT
cord-011435-x73foqu7	167	2	figure	figure	NOUN
cord-011435-x73foqu7	167	3	4f	4f	NUM
cord-011435-x73foqu7	167	4	)	)	PUNCT
cord-011435-x73foqu7	167	5	,	,	PUNCT
cord-011435-x73foqu7	167	6	all	all	PRON
cord-011435-x73foqu7	167	7	of	of	ADP
cord-011435-x73foqu7	167	8	which	which	PRON
cord-011435-x73foqu7	167	9	depend	depend	VERB
cord-011435-x73foqu7	167	10	on	on	ADP
cord-011435-x73foqu7	167	11	the	the	DET
cord-011435-x73foqu7	167	12	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	167	13	activity	activity	NOUN
cord-011435-x73foqu7	167	14	of	of	ADP
cord-011435-x73foqu7	167	15	irf3	irf3	PROPN
cord-011435-x73foqu7	167	16	.	.	PUNCT
cord-011435-x73foqu7	168	1	collectively	collectively	ADV
cord-011435-x73foqu7	168	2	,	,	PUNCT
cord-011435-x73foqu7	168	3	our	our	PRON
cord-011435-x73foqu7	168	4	results	result	NOUN
cord-011435-x73foqu7	168	5	demonstrate	demonstrate	VERB
cord-011435-x73foqu7	168	6	that	that	SCONJ
cord-011435-x73foqu7	168	7	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	168	8	inhibits	inhibit	VERB
cord-011435-x73foqu7	168	9	vsv	vsv	X
cord-011435-x73foqu7	168	10	replication	replication	NOUN
cord-011435-x73foqu7	168	11	in	in	ADP
cord-011435-x73foqu7	168	12	the	the	DET
cord-011435-x73foqu7	168	13	absence	absence	NOUN
cord-011435-x73foqu7	168	14	of	of	ADP
cord-011435-x73foqu7	168	15	irf3	irf3	PROPN
cord-011435-x73foqu7	168	16	-	-	PUNCT
cord-011435-x73foqu7	168	17	induced	induce	VERB
cord-011435-x73foqu7	168	18	antiviral	antiviral	ADJ
cord-011435-x73foqu7	168	19	gene	gene	NOUN
cord-011435-x73foqu7	168	20	expression	expression	NOUN
cord-011435-x73foqu7	168	21	.	.	PUNCT
cord-011435-x73foqu7	169	1	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	169	2	promoted	promote	VERB
cord-011435-x73foqu7	169	3	the	the	DET
cord-011435-x73foqu7	169	4	ripa	ripa	ADJ
cord-011435-x73foqu7	169	5	activity	activity	NOUN
cord-011435-x73foqu7	169	6	,	,	PUNCT
cord-011435-x73foqu7	169	7	measured	measure	VERB
cord-011435-x73foqu7	169	8	by	by	ADP
cord-011435-x73foqu7	169	9	robust	robust	ADJ
cord-011435-x73foqu7	169	10	increase	increase	NOUN
cord-011435-x73foqu7	169	11	in	in	ADP
cord-011435-x73foqu7	169	12	rlr	rlr	NOUN
cord-011435-x73foqu7	169	13	-	-	PUNCT
cord-011435-x73foqu7	169	14	induced	induce	VERB
cord-011435-x73foqu7	169	15	c	c	ADJ
cord-011435-x73foqu7	169	16	-	-	PUNCT
cord-011435-x73foqu7	169	17	parp	parp	NOUN
cord-011435-x73foqu7	169	18	levels	level	NOUN
cord-011435-x73foqu7	169	19	,	,	PUNCT
cord-011435-x73foqu7	169	20	when	when	SCONJ
cord-011435-x73foqu7	169	21	compared	compare	VERB
cord-011435-x73foqu7	169	22	with	with	ADP
cord-011435-x73foqu7	169	23	rlr	rlr	NOUN
cord-011435-x73foqu7	169	24	-	-	PUNCT
cord-011435-x73foqu7	169	25	treated	treat	VERB
cord-011435-x73foqu7	169	26	cells	cell	NOUN
cord-011435-x73foqu7	169	27	(	(	PUNCT
cord-011435-x73foqu7	169	28	figure	figure	NOUN
cord-011435-x73foqu7	169	29	5a	5a	NUM
cord-011435-x73foqu7	169	30	,	,	PUNCT
cord-011435-x73foqu7	169	31	b	b	NOUN
cord-011435-x73foqu7	169	32	)	)	PUNCT
cord-011435-x73foqu7	169	33	.	.	PUNCT
cord-011435-x73foqu7	170	1	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	170	2	is	be	AUX
cord-011435-x73foqu7	170	3	a	a	DET
cord-011435-x73foqu7	170	4	known	know	VERB
cord-011435-x73foqu7	170	5	inducer	inducer	NOUN
cord-011435-x73foqu7	170	6	of	of	ADP
cord-011435-x73foqu7	170	7	the	the	DET
cord-011435-x73foqu7	170	8	cellular	cellular	ADJ
cord-011435-x73foqu7	170	9	apoptotic	apoptotic	ADJ
cord-011435-x73foqu7	170	10	pathway	pathway	NOUN
cord-011435-x73foqu7	170	11	[	[	X
cord-011435-x73foqu7	170	12	29	29	NUM
cord-011435-x73foqu7	170	13	,	,	PUNCT
cord-011435-x73foqu7	170	14	30	30	NUM
cord-011435-x73foqu7	170	15	]	]	PUNCT
cord-011435-x73foqu7	170	16	,	,	PUNCT
cord-011435-x73foqu7	170	17	and	and	CCONJ
cord-011435-x73foqu7	170	18	,	,	PUNCT
cord-011435-x73foqu7	170	19	as	as	SCONJ
cord-011435-x73foqu7	170	20	expected	expect	VERB
cord-011435-x73foqu7	170	21	,	,	PUNCT
cord-011435-x73foqu7	170	22	also	also	ADV
cord-011435-x73foqu7	170	23	triggered	trigger	VERB
cord-011435-x73foqu7	170	24	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	170	25	in	in	ADP
cord-011435-x73foqu7	170	26	the	the	DET
cord-011435-x73foqu7	170	27	absence	absence	NOUN
cord-011435-x73foqu7	170	28	of	of	ADP
cord-011435-x73foqu7	170	29	rlr	rlr	NOUN
cord-011435-x73foqu7	170	30	stimulation	stimulation	NOUN
cord-011435-x73foqu7	170	31	(	(	PUNCT
cord-011435-x73foqu7	170	32	figure	figure	NOUN
cord-011435-x73foqu7	170	33	5a	5a	NUM
cord-011435-x73foqu7	170	34	,	,	PUNCT
cord-011435-x73foqu7	170	35	lane	lane	NOUN
cord-011435-x73foqu7	170	36	2	2	NUM
cord-011435-x73foqu7	170	37	)	)	PUNCT
cord-011435-x73foqu7	170	38	.	.	PUNCT
cord-011435-x73foqu7	171	1	to	to	PART
cord-011435-x73foqu7	171	2	inquire	inquire	VERB
cord-011435-x73foqu7	171	3	genetically	genetically	ADV
cord-011435-x73foqu7	171	4	how	how	SCONJ
cord-011435-x73foqu7	171	5	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	171	6	activates	activate	VERB
cord-011435-x73foqu7	171	7	irf3	irf3	PROPN
cord-011435-x73foqu7	171	8	to	to	PART
cord-011435-x73foqu7	171	9	promote	promote	VERB
cord-011435-x73foqu7	171	10	ripa	ripa	ADJ
cord-011435-x73foqu7	171	11	,	,	PUNCT
cord-011435-x73foqu7	171	12	we	we	PRON
cord-011435-x73foqu7	171	13	took	take	VERB
cord-011435-x73foqu7	171	14	a	a	DET
cord-011435-x73foqu7	171	15	strategy	strategy	NOUN
cord-011435-x73foqu7	171	16	to	to	PART
cord-011435-x73foqu7	171	17	measure	measure	VERB
cord-011435-x73foqu7	171	18	the	the	DET
cord-011435-x73foqu7	171	19	"	"	PUNCT
cord-011435-x73foqu7	171	20	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	171	21	-	-	PUNCT
cord-011435-x73foqu7	171	22	promoted	promote	VERB
cord-011435-x73foqu7	171	23	ripa	ripa	ADJ
cord-011435-x73foqu7	171	24	activity	activity	NOUN
cord-011435-x73foqu7	171	25	"	"	PUNCT
cord-011435-x73foqu7	171	26	using	use	VERB
cord-011435-x73foqu7	171	27	the	the	DET
cord-011435-x73foqu7	171	28	combined	combined	ADJ
cord-011435-x73foqu7	171	29	treatment	treatment	NOUN
cord-011435-x73foqu7	171	30	of	of	ADP
cord-011435-x73foqu7	171	31	rlr	rlr	NOUN
cord-011435-x73foqu7	171	32	and	and	CCONJ
cord-011435-x73foqu7	171	33	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	171	34	(	(	PUNCT
cord-011435-x73foqu7	171	35	"	"	PUNCT
cord-011435-x73foqu7	171	36	rlr	rlr	PROPN
cord-011435-x73foqu7	171	37	/	/	SYM
cord-011435-x73foqu7	171	38	doxo	doxo	PROPN
cord-011435-x73foqu7	171	39	"	"	PUNCT
cord-011435-x73foqu7	171	40	,	,	PUNCT
cord-011435-x73foqu7	171	41	lane	lane	NOUN
cord-011435-x73foqu7	171	42	4	4	NUM
cord-011435-x73foqu7	171	43	,	,	PUNCT
cord-011435-x73foqu7	171	44	figure	figure	NOUN
cord-011435-x73foqu7	171	45	5a	5a	NUM
cord-011435-x73foqu7	171	46	)	)	PUNCT
cord-011435-x73foqu7	171	47	,	,	PUNCT
cord-011435-x73foqu7	171	48	to	to	PART
cord-011435-x73foqu7	171	49	avoid	avoid	VERB
cord-011435-x73foqu7	171	50	the	the	DET
cord-011435-x73foqu7	171	51	individual	individual	ADJ
cord-011435-x73foqu7	171	52	cellular	cellular	ADJ
cord-011435-x73foqu7	171	53	effects	effect	NOUN
cord-011435-x73foqu7	171	54	of	of	ADP
cord-011435-x73foqu7	171	55	rlr	rlr	NOUN
cord-011435-x73foqu7	171	56	or	or	CCONJ
cord-011435-x73foqu7	171	57	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	171	58	(	(	PUNCT
cord-011435-x73foqu7	171	59	lanes	lane	VERB
cord-011435-x73foqu7	171	60	2	2	NUM
cord-011435-x73foqu7	171	61	,	,	PUNCT
cord-011435-x73foqu7	171	62	3	3	NUM
cord-011435-x73foqu7	171	63	,	,	PUNCT
cord-011435-x73foqu7	171	64	figure	figure	NOUN
cord-011435-x73foqu7	171	65	5a	5a	NUM
cord-011435-x73foqu7	171	66	)	)	PUNCT
cord-011435-x73foqu7	171	67	.	.	PUNCT
cord-011435-x73foqu7	172	1	similar	similar	ADJ
cord-011435-x73foqu7	172	2	to	to	ADP
cord-011435-x73foqu7	172	3	c	c	NOUN
cord-011435-x73foqu7	172	4	-	-	NOUN
cord-011435-x73foqu7	172	5	parp	parp	NOUN
cord-011435-x73foqu7	172	6	,	,	PUNCT
cord-011435-x73foqu7	172	7	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	172	8	significantly	significantly	ADV
cord-011435-x73foqu7	172	9	increased	increase	VERB
cord-011435-x73foqu7	172	10	the	the	DET
cord-011435-x73foqu7	172	11	rlr	rlr	NOUN
cord-011435-x73foqu7	172	12	-	-	PUNCT
cord-011435-x73foqu7	172	13	induced	induce	VERB
cord-011435-x73foqu7	172	14	caspase-3	caspase-3	PROPN
cord-011435-x73foqu7	172	15	activity	activity	NOUN
cord-011435-x73foqu7	172	16	(	(	PUNCT
cord-011435-x73foqu7	172	17	figure	figure	NOUN
cord-011435-x73foqu7	172	18	5c	5c	NOUN
cord-011435-x73foqu7	172	19	)	)	PUNCT
cord-011435-x73foqu7	172	20	.	.	PUNCT
cord-011435-x73foqu7	173	1	the	the	DET
cord-011435-x73foqu7	173	2	increased	increase	VERB
cord-011435-x73foqu7	173	3	ripa	ripa	ADJ
cord-011435-x73foqu7	173	4	activity	activity	NOUN
cord-011435-x73foqu7	173	5	by	by	ADP
cord-011435-x73foqu7	173	6	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	173	7	,	,	PUNCT
cord-011435-x73foqu7	173	8	as	as	SCONJ
cord-011435-x73foqu7	173	9	expected	expect	VERB
cord-011435-x73foqu7	173	10	,	,	PUNCT
cord-011435-x73foqu7	173	11	led	lead	VERB
cord-011435-x73foqu7	173	12	to	to	ADP
cord-011435-x73foqu7	173	13	enhanced	enhance	VERB
cord-011435-x73foqu7	173	14	cell	cell	NOUN
cord-011435-x73foqu7	173	15	death	death	NOUN
cord-011435-x73foqu7	173	16	in	in	ADP
cord-011435-x73foqu7	173	17	a	a	DET
cord-011435-x73foqu7	173	18	dose	dose	NOUN
cord-011435-x73foqu7	173	19	-	-	PUNCT
cord-011435-x73foqu7	173	20	dependent	dependent	ADJ
cord-011435-x73foqu7	173	21	manner	manner	NOUN
cord-011435-x73foqu7	173	22	(	(	PUNCT
cord-011435-x73foqu7	173	23	figure	figure	NOUN
cord-011435-x73foqu7	173	24	s3c	s3c	PROPN
cord-011435-x73foqu7	173	25	)	)	PUNCT
cord-011435-x73foqu7	173	26	.	.	PUNCT
cord-011435-x73foqu7	174	1	we	we	PRON
cord-011435-x73foqu7	174	2	examined	examine	VERB
cord-011435-x73foqu7	174	3	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	174	4	-	-	PUNCT
cord-011435-x73foqu7	174	5	promoted	promote	VERB
cord-011435-x73foqu7	174	6	ripa	ripa	NOUN
cord-011435-x73foqu7	174	7	in	in	ADP
cord-011435-x73foqu7	174	8	wt	wt	PROPN
cord-011435-x73foqu7	174	9	and	and	CCONJ
cord-011435-x73foqu7	174	10	irf3	irf3	PROPN
cord-011435-x73foqu7	174	11	−/−	−/−	NUM
cord-011435-x73foqu7	174	12	cells	cell	NOUN
cord-011435-x73foqu7	174	13	.	.	PUNCT
cord-011435-x73foqu7	175	1	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	175	2	caused	cause	VERB
cord-011435-x73foqu7	175	3	robust	robust	ADJ
cord-011435-x73foqu7	175	4	increase	increase	NOUN
cord-011435-x73foqu7	175	5	in	in	ADP
cord-011435-x73foqu7	175	6	rlr	rlr	NOUN
cord-011435-x73foqu7	175	7	-	-	PUNCT
cord-011435-x73foqu7	175	8	induced	induce	VERB
cord-011435-x73foqu7	175	9	c	c	NOUN
cord-011435-x73foqu7	175	10	-	-	PUNCT
cord-011435-x73foqu7	175	11	parp	parp	NOUN
cord-011435-x73foqu7	175	12	and	and	CCONJ
cord-011435-x73foqu7	175	13	capsase-3	capsase-3	VERB
cord-011435-x73foqu7	175	14	activation	activation	NOUN
cord-011435-x73foqu7	175	15	in	in	ADP
cord-011435-x73foqu7	175	16	wt	wt	PROPN
cord-011435-x73foqu7	175	17	cells	cell	NOUN
cord-011435-x73foqu7	175	18	(	(	PUNCT
cord-011435-x73foqu7	175	19	figures	figure	NOUN
cord-011435-x73foqu7	175	20	5d	5d	PROPN
cord-011435-x73foqu7	175	21	,	,	PUNCT
cord-011435-x73foqu7	175	22	e	e	PROPN
cord-011435-x73foqu7	175	23	)	)	PUNCT
cord-011435-x73foqu7	175	24	.	.	PUNCT
cord-011435-x73foqu7	176	1	the	the	DET
cord-011435-x73foqu7	176	2	rlr	rlr	PROPN
cord-011435-x73foqu7	176	3	/	/	SYM
cord-011435-x73foqu7	176	4	doxorubicininduced	doxorubicininduce	VERB
cord-011435-x73foqu7	176	5	c	c	PROPN
cord-011435-x73foqu7	176	6	-	-	PUNCT
cord-011435-x73foqu7	176	7	parp	parp	NOUN
cord-011435-x73foqu7	176	8	and	and	CCONJ
cord-011435-x73foqu7	176	9	caspase	caspase	NOUN
cord-011435-x73foqu7	176	10	activity	activity	NOUN
cord-011435-x73foqu7	176	11	were	be	AUX
cord-011435-x73foqu7	176	12	reduced	reduce	VERB
cord-011435-x73foqu7	176	13	in	in	ADP
cord-011435-x73foqu7	176	14	irf3	irf3	PROPN
cord-011435-x73foqu7	176	15	−/−	−/−	NUM
cord-011435-x73foqu7	176	16	cells	cell	NOUN
cord-011435-x73foqu7	176	17	(	(	PUNCT
cord-011435-x73foqu7	176	18	figure	figure	NOUN
cord-011435-x73foqu7	176	19	5d	5d	PROPN
cord-011435-x73foqu7	176	20	,	,	PUNCT
cord-011435-x73foqu7	176	21	e	e	PROPN
cord-011435-x73foqu7	176	22	)	)	PUNCT
cord-011435-x73foqu7	176	23	.	.	PUNCT
cord-011435-x73foqu7	177	1	because	because	SCONJ
cord-011435-x73foqu7	177	2	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	177	3	specifically	specifically	ADV
cord-011435-x73foqu7	177	4	promotes	promote	VERB
cord-011435-x73foqu7	177	5	the	the	DET
cord-011435-x73foqu7	177	6	ripa	ripa	NOUN
cord-011435-x73foqu7	177	7	,	,	PUNCT
cord-011435-x73foqu7	177	8	and	and	CCONJ
cord-011435-x73foqu7	177	9	not	not	PART
cord-011435-x73foqu7	177	10	the	the	DET
cord-011435-x73foqu7	177	11	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	177	12	activity	activity	NOUN
cord-011435-x73foqu7	177	13	of	of	ADP
cord-011435-x73foqu7	177	14	irf3	irf3	PROPN
cord-011435-x73foqu7	177	15	,	,	PUNCT
cord-011435-x73foqu7	177	16	we	we	PRON
cord-011435-x73foqu7	177	17	used	use	VERB
cord-011435-x73foqu7	177	18	a	a	DET
cord-011435-x73foqu7	177	19	nt	nt	PROPN
cord-011435-x73foqu7	177	20	-	-	PUNCT
cord-011435-x73foqu7	177	21	irf3	irf3	PROPN
cord-011435-x73foqu7	177	22	mutant	mutant	NOUN
cord-011435-x73foqu7	177	23	,	,	PUNCT
cord-011435-x73foqu7	177	24	irf3	irf3	PROPN
cord-011435-x73foqu7	177	25	-	-	PUNCT
cord-011435-x73foqu7	177	26	k10	k10	PROPN
cord-011435-x73foqu7	177	27	,	,	PUNCT
cord-011435-x73foqu7	177	28	which	which	PRON
cord-011435-x73foqu7	177	29	is	be	AUX
cord-011435-x73foqu7	177	30	functional	functional	ADJ
cord-011435-x73foqu7	177	31	only	only	ADV
cord-011435-x73foqu7	177	32	in	in	ADP
cord-011435-x73foqu7	177	33	the	the	DET
cord-011435-x73foqu7	177	34	ripa	ripa	NOUN
cord-011435-x73foqu7	177	35	,	,	PUNCT
cord-011435-x73foqu7	177	36	but	but	CCONJ
cord-011435-x73foqu7	177	37	not	not	PART
cord-011435-x73foqu7	177	38	the	the	DET
cord-011435-x73foqu7	177	39	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	177	40	branch	branch	NOUN
cord-011435-x73foqu7	177	41	[	[	PUNCT
cord-011435-x73foqu7	177	42	7	7	NUM
cord-011435-x73foqu7	177	43	]	]	PUNCT
cord-011435-x73foqu7	177	44	.	.	PUNCT
cord-011435-x73foqu7	178	1	the	the	DET
cord-011435-x73foqu7	178	2	irf3	irf3	PROPN
cord-011435-x73foqu7	178	3	-	-	PUNCT
cord-011435-x73foqu7	178	4	k10	k10	PROPN
cord-011435-x73foqu7	178	5	-	-	PUNCT
cord-011435-x73foqu7	178	6	expressing	express	VERB
cord-011435-x73foqu7	178	7	cells	cell	NOUN
cord-011435-x73foqu7	178	8	showed	show	VERB
cord-011435-x73foqu7	178	9	strong	strong	ADJ
cord-011435-x73foqu7	178	10	promotion	promotion	NOUN
cord-011435-x73foqu7	178	11	of	of	ADP
cord-011435-x73foqu7	178	12	ripa	ripa	ADJ
cord-011435-x73foqu7	178	13	activity	activity	NOUN
cord-011435-x73foqu7	178	14	upon	upon	SCONJ
cord-011435-x73foqu7	178	15	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	178	16	treatment	treatment	NOUN
cord-011435-x73foqu7	178	17	(	(	PUNCT
cord-011435-x73foqu7	178	18	figure	figure	NOUN
cord-011435-x73foqu7	178	19	5f	5f	NUM
cord-011435-x73foqu7	178	20	)	)	PUNCT
cord-011435-x73foqu7	178	21	.	.	PUNCT
cord-011435-x73foqu7	179	1	collectively	collectively	ADV
cord-011435-x73foqu7	179	2	,	,	PUNCT
cord-011435-x73foqu7	179	3	our	our	PRON
cord-011435-x73foqu7	179	4	results	result	NOUN
cord-011435-x73foqu7	179	5	demonstrate	demonstrate	VERB
cord-011435-x73foqu7	179	6	that	that	SCONJ
cord-011435-x73foqu7	179	7	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	179	8	inhibits	inhibit	VERB
cord-011435-x73foqu7	179	9	the	the	DET
cord-011435-x73foqu7	179	10	transcriptional	transcriptional	NOUN
cord-011435-x73foqu7	179	11	,	,	PUNCT
cord-011435-x73foqu7	179	12	but	but	CCONJ
cord-011435-x73foqu7	179	13	promotes	promote	VERB
cord-011435-x73foqu7	179	14	the	the	DET
cord-011435-x73foqu7	179	15	ripa	ripa	NOUN
cord-011435-x73foqu7	179	16	,	,	PUNCT
cord-011435-x73foqu7	179	17	activity	activity	NOUN
cord-011435-x73foqu7	179	18	of	of	ADP
cord-011435-x73foqu7	179	19	irf3	irf3	PROPN
cord-011435-x73foqu7	179	20	.	.	PUNCT
cord-011435-x73foqu7	180	1	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	180	2	promoted	promote	VERB
cord-011435-x73foqu7	180	3	the	the	DET
cord-011435-x73foqu7	180	4	ripa	ripa	ADJ
cord-011435-x73foqu7	180	5	activity	activity	NOUN
cord-011435-x73foqu7	180	6	,	,	PUNCT
cord-011435-x73foqu7	180	7	measured	measure	VERB
cord-011435-x73foqu7	180	8	by	by	ADP
cord-011435-x73foqu7	180	9	robust	robust	ADJ
cord-011435-x73foqu7	180	10	increase	increase	NOUN
cord-011435-x73foqu7	180	11	in	in	ADP
cord-011435-x73foqu7	180	12	rlr	rlr	NOUN
cord-011435-x73foqu7	180	13	-	-	PUNCT
cord-011435-x73foqu7	180	14	induced	induce	VERB
cord-011435-x73foqu7	180	15	c	c	ADJ
cord-011435-x73foqu7	180	16	-	-	PUNCT
cord-011435-x73foqu7	180	17	parp	parp	NOUN
cord-011435-x73foqu7	180	18	levels	level	NOUN
cord-011435-x73foqu7	180	19	,	,	PUNCT
cord-011435-x73foqu7	180	20	when	when	SCONJ
cord-011435-x73foqu7	180	21	compared	compare	VERB
cord-011435-x73foqu7	180	22	with	with	ADP
cord-011435-x73foqu7	180	23	rlr	rlr	NOUN
cord-011435-x73foqu7	180	24	-	-	PUNCT
cord-011435-x73foqu7	180	25	treated	treat	VERB
cord-011435-x73foqu7	180	26	cells	cell	NOUN
cord-011435-x73foqu7	180	27	(	(	PUNCT
cord-011435-x73foqu7	180	28	figure	figure	NOUN
cord-011435-x73foqu7	180	29	5a	5a	NUM
cord-011435-x73foqu7	180	30	,	,	PUNCT
cord-011435-x73foqu7	180	31	b	b	NOUN
cord-011435-x73foqu7	180	32	)	)	PUNCT
cord-011435-x73foqu7	180	33	.	.	PUNCT
cord-011435-x73foqu7	181	1	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	181	2	is	be	AUX
cord-011435-x73foqu7	181	3	a	a	DET
cord-011435-x73foqu7	181	4	known	know	VERB
cord-011435-x73foqu7	181	5	inducer	inducer	NOUN
cord-011435-x73foqu7	181	6	of	of	ADP
cord-011435-x73foqu7	181	7	the	the	DET
cord-011435-x73foqu7	181	8	cellular	cellular	ADJ
cord-011435-x73foqu7	181	9	apoptotic	apoptotic	ADJ
cord-011435-x73foqu7	181	10	pathway	pathway	NOUN
cord-011435-x73foqu7	181	11	[	[	X
cord-011435-x73foqu7	181	12	29	29	NUM
cord-011435-x73foqu7	181	13	,	,	PUNCT
cord-011435-x73foqu7	181	14	30	30	NUM
cord-011435-x73foqu7	181	15	]	]	PUNCT
cord-011435-x73foqu7	181	16	,	,	PUNCT
cord-011435-x73foqu7	181	17	and	and	CCONJ
cord-011435-x73foqu7	181	18	,	,	PUNCT
cord-011435-x73foqu7	181	19	as	as	SCONJ
cord-011435-x73foqu7	181	20	expected	expect	VERB
cord-011435-x73foqu7	181	21	,	,	PUNCT
cord-011435-x73foqu7	181	22	also	also	ADV
cord-011435-x73foqu7	181	23	triggered	trigger	VERB
cord-011435-x73foqu7	181	24	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	181	25	in	in	ADP
cord-011435-x73foqu7	181	26	the	the	DET
cord-011435-x73foqu7	181	27	absence	absence	NOUN
cord-011435-x73foqu7	181	28	of	of	ADP
cord-011435-x73foqu7	181	29	rlr	rlr	NOUN
cord-011435-x73foqu7	181	30	stimulation	stimulation	NOUN
cord-011435-x73foqu7	181	31	(	(	PUNCT
cord-011435-x73foqu7	181	32	figure	figure	NOUN
cord-011435-x73foqu7	181	33	5a	5a	NUM
cord-011435-x73foqu7	181	34	,	,	PUNCT
cord-011435-x73foqu7	181	35	lane	lane	NOUN
cord-011435-x73foqu7	181	36	2	2	NUM
cord-011435-x73foqu7	181	37	)	)	PUNCT
cord-011435-x73foqu7	181	38	.	.	PUNCT
cord-011435-x73foqu7	182	1	to	to	PART
cord-011435-x73foqu7	182	2	inquire	inquire	VERB
cord-011435-x73foqu7	182	3	genetically	genetically	ADV
cord-011435-x73foqu7	182	4	how	how	SCONJ
cord-011435-x73foqu7	182	5	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	182	6	activates	activate	VERB
cord-011435-x73foqu7	182	7	irf3	irf3	PROPN
cord-011435-x73foqu7	182	8	to	to	PART
cord-011435-x73foqu7	182	9	promote	promote	VERB
cord-011435-x73foqu7	182	10	ripa	ripa	ADJ
cord-011435-x73foqu7	182	11	,	,	PUNCT
cord-011435-x73foqu7	182	12	we	we	PRON
cord-011435-x73foqu7	182	13	took	take	VERB
cord-011435-x73foqu7	182	14	a	a	DET
cord-011435-x73foqu7	182	15	strategy	strategy	NOUN
cord-011435-x73foqu7	182	16	to	to	PART
cord-011435-x73foqu7	182	17	measure	measure	VERB
cord-011435-x73foqu7	182	18	the	the	DET
cord-011435-x73foqu7	182	19	"	"	PUNCT
cord-011435-x73foqu7	182	20	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	182	21	-	-	PUNCT
cord-011435-x73foqu7	182	22	promoted	promote	VERB
cord-011435-x73foqu7	182	23	ripa	ripa	ADJ
cord-011435-x73foqu7	182	24	activity	activity	NOUN
cord-011435-x73foqu7	182	25	"	"	PUNCT
cord-011435-x73foqu7	182	26	using	use	VERB
cord-011435-x73foqu7	182	27	the	the	DET
cord-011435-x73foqu7	182	28	combined	combined	ADJ
cord-011435-x73foqu7	182	29	treatment	treatment	NOUN
cord-011435-x73foqu7	182	30	of	of	ADP
cord-011435-x73foqu7	182	31	rlr	rlr	NOUN
cord-011435-x73foqu7	182	32	and	and	CCONJ
cord-011435-x73foqu7	182	33	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	182	34	(	(	PUNCT
cord-011435-x73foqu7	182	35	"	"	PUNCT
cord-011435-x73foqu7	182	36	rlr	rlr	PROPN
cord-011435-x73foqu7	182	37	/	/	SYM
cord-011435-x73foqu7	182	38	doxo	doxo	PROPN
cord-011435-x73foqu7	182	39	"	"	PUNCT
cord-011435-x73foqu7	182	40	,	,	PUNCT
cord-011435-x73foqu7	182	41	lane	lane	NOUN
cord-011435-x73foqu7	182	42	4	4	NUM
cord-011435-x73foqu7	182	43	,	,	PUNCT
cord-011435-x73foqu7	182	44	figure	figure	NOUN
cord-011435-x73foqu7	182	45	5a	5a	NUM
cord-011435-x73foqu7	182	46	)	)	PUNCT
cord-011435-x73foqu7	182	47	,	,	PUNCT
cord-011435-x73foqu7	182	48	to	to	PART
cord-011435-x73foqu7	182	49	avoid	avoid	VERB
cord-011435-x73foqu7	182	50	the	the	DET
cord-011435-x73foqu7	182	51	individual	individual	ADJ
cord-011435-x73foqu7	182	52	cellular	cellular	ADJ
cord-011435-x73foqu7	182	53	effects	effect	NOUN
cord-011435-x73foqu7	182	54	of	of	ADP
cord-011435-x73foqu7	182	55	rlr	rlr	NOUN
cord-011435-x73foqu7	182	56	or	or	CCONJ
cord-011435-x73foqu7	182	57	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	182	58	(	(	PUNCT
cord-011435-x73foqu7	182	59	lanes	lane	VERB
cord-011435-x73foqu7	182	60	2	2	NUM
cord-011435-x73foqu7	182	61	,	,	PUNCT
cord-011435-x73foqu7	182	62	3	3	NUM
cord-011435-x73foqu7	182	63	,	,	PUNCT
cord-011435-x73foqu7	182	64	figure	figure	NOUN
cord-011435-x73foqu7	182	65	5a	5a	NUM
cord-011435-x73foqu7	182	66	)	)	PUNCT
cord-011435-x73foqu7	182	67	.	.	PUNCT
cord-011435-x73foqu7	183	1	similar	similar	ADJ
cord-011435-x73foqu7	183	2	to	to	ADP
cord-011435-x73foqu7	183	3	c	c	NOUN
cord-011435-x73foqu7	183	4	-	-	NOUN
cord-011435-x73foqu7	183	5	parp	parp	NOUN
cord-011435-x73foqu7	183	6	,	,	PUNCT
cord-011435-x73foqu7	183	7	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	183	8	significantly	significantly	ADV
cord-011435-x73foqu7	183	9	increased	increase	VERB
cord-011435-x73foqu7	183	10	the	the	DET
cord-011435-x73foqu7	183	11	rlr	rlr	NOUN
cord-011435-x73foqu7	183	12	-	-	PUNCT
cord-011435-x73foqu7	183	13	induced	induce	VERB
cord-011435-x73foqu7	183	14	caspase-3	caspase-3	PROPN
cord-011435-x73foqu7	183	15	activity	activity	NOUN
cord-011435-x73foqu7	183	16	(	(	PUNCT
cord-011435-x73foqu7	183	17	figure	figure	NOUN
cord-011435-x73foqu7	183	18	5c	5c	NOUN
cord-011435-x73foqu7	183	19	)	)	PUNCT
cord-011435-x73foqu7	183	20	.	.	PUNCT
cord-011435-x73foqu7	184	1	the	the	DET
cord-011435-x73foqu7	184	2	increased	increase	VERB
cord-011435-x73foqu7	184	3	ripa	ripa	ADJ
cord-011435-x73foqu7	184	4	activity	activity	NOUN
cord-011435-x73foqu7	184	5	by	by	ADP
cord-011435-x73foqu7	184	6	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	184	7	,	,	PUNCT
cord-011435-x73foqu7	184	8	as	as	SCONJ
cord-011435-x73foqu7	184	9	expected	expect	VERB
cord-011435-x73foqu7	184	10	,	,	PUNCT
cord-011435-x73foqu7	184	11	led	lead	VERB
cord-011435-x73foqu7	184	12	to	to	ADP
cord-011435-x73foqu7	184	13	enhanced	enhance	VERB
cord-011435-x73foqu7	184	14	cell	cell	NOUN
cord-011435-x73foqu7	184	15	death	death	NOUN
cord-011435-x73foqu7	184	16	in	in	ADP
cord-011435-x73foqu7	184	17	a	a	DET
cord-011435-x73foqu7	184	18	dose	dose	NOUN
cord-011435-x73foqu7	184	19	-	-	PUNCT
cord-011435-x73foqu7	184	20	dependent	dependent	ADJ
cord-011435-x73foqu7	184	21	manner	manner	NOUN
cord-011435-x73foqu7	184	22	(	(	PUNCT
cord-011435-x73foqu7	184	23	figure	figure	NOUN
cord-011435-x73foqu7	184	24	s3c	s3c	PROPN
cord-011435-x73foqu7	184	25	)	)	PUNCT
cord-011435-x73foqu7	184	26	.	.	PUNCT
cord-011435-x73foqu7	185	1	we	we	PRON
cord-011435-x73foqu7	185	2	examined	examine	VERB
cord-011435-x73foqu7	185	3	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	185	4	-	-	PUNCT
cord-011435-x73foqu7	185	5	promoted	promote	VERB
cord-011435-x73foqu7	185	6	ripa	ripa	NOUN
cord-011435-x73foqu7	185	7	in	in	ADP
cord-011435-x73foqu7	185	8	wt	wt	PROPN
cord-011435-x73foqu7	185	9	and	and	CCONJ
cord-011435-x73foqu7	185	10	irf3	irf3	PROPN
cord-011435-x73foqu7	185	11	−/−	−/−	NUM
cord-011435-x73foqu7	185	12	cells	cell	NOUN
cord-011435-x73foqu7	185	13	.	.	PUNCT
cord-011435-x73foqu7	186	1	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	186	2	caused	cause	VERB
cord-011435-x73foqu7	186	3	robust	robust	ADJ
cord-011435-x73foqu7	186	4	increase	increase	NOUN
cord-011435-x73foqu7	186	5	in	in	ADP
cord-011435-x73foqu7	186	6	rlr	rlr	NOUN
cord-011435-x73foqu7	186	7	-	-	PUNCT
cord-011435-x73foqu7	186	8	induced	induce	VERB
cord-011435-x73foqu7	186	9	c	c	NOUN
cord-011435-x73foqu7	186	10	-	-	PUNCT
cord-011435-x73foqu7	186	11	parp	parp	NOUN
cord-011435-x73foqu7	186	12	and	and	CCONJ
cord-011435-x73foqu7	186	13	capsase-3	capsase-3	VERB
cord-011435-x73foqu7	186	14	activation	activation	NOUN
cord-011435-x73foqu7	186	15	in	in	ADP
cord-011435-x73foqu7	186	16	wt	wt	PROPN
cord-011435-x73foqu7	186	17	cells	cell	NOUN
cord-011435-x73foqu7	186	18	(	(	PUNCT
cord-011435-x73foqu7	186	19	figure	figure	NOUN
cord-011435-x73foqu7	186	20	5d	5d	PROPN
cord-011435-x73foqu7	186	21	,	,	PUNCT
cord-011435-x73foqu7	186	22	e	e	PROPN
cord-011435-x73foqu7	186	23	)	)	PUNCT
cord-011435-x73foqu7	186	24	.	.	PUNCT
cord-011435-x73foqu7	187	1	the	the	DET
cord-011435-x73foqu7	187	2	rlr	rlr	PROPN
cord-011435-x73foqu7	187	3	/	/	SYM
cord-011435-x73foqu7	187	4	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	187	5	-	-	PUNCT
cord-011435-x73foqu7	187	6	induced	induce	VERB
cord-011435-x73foqu7	187	7	c	c	NOUN
cord-011435-x73foqu7	187	8	-	-	PUNCT
cord-011435-x73foqu7	187	9	parp	parp	NOUN
cord-011435-x73foqu7	187	10	and	and	CCONJ
cord-011435-x73foqu7	187	11	caspase	caspase	NOUN
cord-011435-x73foqu7	187	12	activity	activity	NOUN
cord-011435-x73foqu7	187	13	were	be	AUX
cord-011435-x73foqu7	187	14	reduced	reduce	VERB
cord-011435-x73foqu7	187	15	in	in	ADP
cord-011435-x73foqu7	187	16	irf3	irf3	PROPN
cord-011435-x73foqu7	187	17	−/−	−/−	NUM
cord-011435-x73foqu7	187	18	cells	cell	NOUN
cord-011435-x73foqu7	187	19	(	(	PUNCT
cord-011435-x73foqu7	187	20	figure	figure	NOUN
cord-011435-x73foqu7	187	21	5d	5d	PROPN
cord-011435-x73foqu7	187	22	,	,	PUNCT
cord-011435-x73foqu7	187	23	e	e	PROPN
cord-011435-x73foqu7	187	24	)	)	PUNCT
cord-011435-x73foqu7	187	25	.	.	PUNCT
cord-011435-x73foqu7	188	1	because	because	SCONJ
cord-011435-x73foqu7	188	2	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	188	3	specifically	specifically	ADV
cord-011435-x73foqu7	188	4	promotes	promote	VERB
cord-011435-x73foqu7	188	5	the	the	DET
cord-011435-x73foqu7	188	6	ripa	ripa	NOUN
cord-011435-x73foqu7	188	7	,	,	PUNCT
cord-011435-x73foqu7	188	8	and	and	CCONJ
cord-011435-x73foqu7	188	9	not	not	PART
cord-011435-x73foqu7	188	10	the	the	DET
cord-011435-x73foqu7	188	11	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	188	12	activity	activity	NOUN
cord-011435-x73foqu7	188	13	of	of	ADP
cord-011435-x73foqu7	188	14	irf3	irf3	PROPN
cord-011435-x73foqu7	188	15	,	,	PUNCT
cord-011435-x73foqu7	188	16	we	we	PRON
cord-011435-x73foqu7	188	17	used	use	VERB
cord-011435-x73foqu7	188	18	a	a	DET
cord-011435-x73foqu7	188	19	nt	nt	PROPN
cord-011435-x73foqu7	188	20	-	-	PUNCT
cord-011435-x73foqu7	188	21	irf3	irf3	PROPN
cord-011435-x73foqu7	188	22	mutant	mutant	NOUN
cord-011435-x73foqu7	188	23	,	,	PUNCT
cord-011435-x73foqu7	188	24	irf3	irf3	PROPN
cord-011435-x73foqu7	188	25	-	-	PUNCT
cord-011435-x73foqu7	188	26	k10	k10	PROPN
cord-011435-x73foqu7	188	27	,	,	PUNCT
cord-011435-x73foqu7	188	28	which	which	PRON
cord-011435-x73foqu7	188	29	is	be	AUX
cord-011435-x73foqu7	188	30	functional	functional	ADJ
cord-011435-x73foqu7	188	31	only	only	ADV
cord-011435-x73foqu7	188	32	in	in	ADP
cord-011435-x73foqu7	188	33	the	the	DET
cord-011435-x73foqu7	188	34	ripa	ripa	NOUN
cord-011435-x73foqu7	188	35	,	,	PUNCT
cord-011435-x73foqu7	188	36	but	but	CCONJ
cord-011435-x73foqu7	188	37	not	not	PART
cord-011435-x73foqu7	188	38	the	the	DET
cord-011435-x73foqu7	188	39	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	188	40	branch	branch	NOUN
cord-011435-x73foqu7	188	41	[	[	PUNCT
cord-011435-x73foqu7	188	42	7	7	NUM
cord-011435-x73foqu7	188	43	]	]	PUNCT
cord-011435-x73foqu7	188	44	.	.	PUNCT
cord-011435-x73foqu7	189	1	the	the	DET
cord-011435-x73foqu7	189	2	irf3	irf3	PROPN
cord-011435-x73foqu7	189	3	-	-	PUNCT
cord-011435-x73foqu7	189	4	k10	k10	PROPN
cord-011435-x73foqu7	189	5	-	-	PUNCT
cord-011435-x73foqu7	189	6	expressing	express	VERB
cord-011435-x73foqu7	189	7	cells	cell	NOUN
cord-011435-x73foqu7	189	8	showed	show	VERB
cord-011435-x73foqu7	189	9	strong	strong	ADJ
cord-011435-x73foqu7	189	10	promotion	promotion	NOUN
cord-011435-x73foqu7	189	11	of	of	ADP
cord-011435-x73foqu7	189	12	ripa	ripa	ADJ
cord-011435-x73foqu7	189	13	activity	activity	NOUN
cord-011435-x73foqu7	189	14	upon	upon	SCONJ
cord-011435-x73foqu7	189	15	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	189	16	treatment	treatment	NOUN
cord-011435-x73foqu7	189	17	(	(	PUNCT
cord-011435-x73foqu7	189	18	figure	figure	NOUN
cord-011435-x73foqu7	189	19	5f	5f	NUM
cord-011435-x73foqu7	189	20	)	)	PUNCT
cord-011435-x73foqu7	189	21	.	.	PUNCT
cord-011435-x73foqu7	190	1	collectively	collectively	ADV
cord-011435-x73foqu7	190	2	,	,	PUNCT
cord-011435-x73foqu7	190	3	our	our	PRON
cord-011435-x73foqu7	190	4	results	result	NOUN
cord-011435-x73foqu7	190	5	demonstrate	demonstrate	VERB
cord-011435-x73foqu7	190	6	that	that	SCONJ
cord-011435-x73foqu7	190	7	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	190	8	inhibits	inhibit	VERB
cord-011435-x73foqu7	190	9	the	the	DET
cord-011435-x73foqu7	190	10	transcriptional	transcriptional	NOUN
cord-011435-x73foqu7	190	11	,	,	PUNCT
cord-011435-x73foqu7	190	12	but	but	CCONJ
cord-011435-x73foqu7	190	13	promotes	promote	VERB
cord-011435-x73foqu7	190	14	the	the	DET
cord-011435-x73foqu7	190	15	ripa	ripa	NOUN
cord-011435-x73foqu7	190	16	,	,	PUNCT
cord-011435-x73foqu7	190	17	activity	activity	NOUN
cord-011435-x73foqu7	190	18	of	of	ADP
cord-011435-x73foqu7	190	19	irf3	irf3	PROPN
cord-011435-x73foqu7	190	20	.	.	PUNCT
cord-011435-x73foqu7	191	1	to	to	PART
cord-011435-x73foqu7	191	2	investigate	investigate	VERB
cord-011435-x73foqu7	191	3	the	the	DET
cord-011435-x73foqu7	191	4	biochemical	biochemical	ADJ
cord-011435-x73foqu7	191	5	mechanism	mechanism	NOUN
cord-011435-x73foqu7	191	6	by	by	ADP
cord-011435-x73foqu7	191	7	which	which	PRON
cord-011435-x73foqu7	191	8	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	191	9	promotes	promote	VERB
cord-011435-x73foqu7	191	10	ripa	ripa	PROPN
cord-011435-x73foqu7	191	11	,	,	PUNCT
cord-011435-x73foqu7	191	12	we	we	PRON
cord-011435-x73foqu7	191	13	examined	examine	VERB
cord-011435-x73foqu7	191	14	whether	whether	SCONJ
cord-011435-x73foqu7	191	15	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	191	16	activates	activate	VERB
cord-011435-x73foqu7	191	17	any	any	DET
cord-011435-x73foqu7	191	18	specific	specific	ADJ
cord-011435-x73foqu7	191	19	step(s	step(s	NOUN
cord-011435-x73foqu7	191	20	)	)	PUNCT
cord-011435-x73foqu7	191	21	of	of	ADP
cord-011435-x73foqu7	191	22	ripa	ripa	PROPN
cord-011435-x73foqu7	191	23	(	(	PUNCT
cord-011435-x73foqu7	191	24	depicted	depict	VERB
cord-011435-x73foqu7	191	25	in	in	ADP
cord-011435-x73foqu7	191	26	figure	figure	NOUN
cord-011435-x73foqu7	191	27	1a	1a	NUM
cord-011435-x73foqu7	191	28	)	)	PUNCT
cord-011435-x73foqu7	191	29	.	.	PUNCT
cord-011435-x73foqu7	192	1	we	we	PRON
cord-011435-x73foqu7	192	2	systematically	systematically	ADV
cord-011435-x73foqu7	192	3	analyzed	analyze	VERB
cord-011435-x73foqu7	192	4	both	both	PRON
cord-011435-x73foqu7	192	5	pre	pre	ADJ
cord-011435-x73foqu7	192	6	-	-	ADJ
cord-011435-x73foqu7	192	7	and	and	CCONJ
cord-011435-x73foqu7	192	8	postmitochondrial	postmitochondrial	ADJ
cord-011435-x73foqu7	192	9	steps	step	NOUN
cord-011435-x73foqu7	192	10	of	of	ADP
cord-011435-x73foqu7	192	11	ripa	ripa	NOUN
cord-011435-x73foqu7	192	12	.	.	PUNCT
cord-011435-x73foqu7	193	1	the	the	DET
cord-011435-x73foqu7	193	2	ubiquitination	ubiquitination	NOUN
cord-011435-x73foqu7	193	3	of	of	ADP
cord-011435-x73foqu7	193	4	irf3	irf3	PROPN
cord-011435-x73foqu7	193	5	(	(	PUNCT
cord-011435-x73foqu7	193	6	stage-1	stage-1	PROPN
cord-011435-x73foqu7	193	7	,	,	PUNCT
cord-011435-x73foqu7	193	8	figure	figure	VERB
cord-011435-x73foqu7	193	9	1a	1a	NUM
cord-011435-x73foqu7	193	10	)	)	PUNCT
cord-011435-x73foqu7	193	11	,	,	PUNCT
cord-011435-x73foqu7	193	12	which	which	PRON
cord-011435-x73foqu7	193	13	is	be	AUX
cord-011435-x73foqu7	193	14	essential	essential	ADJ
cord-011435-x73foqu7	193	15	for	for	ADP
cord-011435-x73foqu7	193	16	activating	activate	VERB
cord-011435-x73foqu7	193	17	ripa	ripa	NOUN
cord-011435-x73foqu7	193	18	,	,	PUNCT
cord-011435-x73foqu7	193	19	was	be	AUX
cord-011435-x73foqu7	193	20	not	not	PART
cord-011435-x73foqu7	193	21	promoted	promote	VERB
cord-011435-x73foqu7	193	22	by	by	ADP
cord-011435-x73foqu7	193	23	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	193	24	(	(	PUNCT
cord-011435-x73foqu7	193	25	figure	figure	VERB
cord-011435-x73foqu7	193	26	6a	6a	NOUN
cord-011435-x73foqu7	193	27	)	)	PUNCT
cord-011435-x73foqu7	193	28	.	.	PUNCT
cord-011435-x73foqu7	194	1	we	we	PRON
cord-011435-x73foqu7	194	2	noted	note	VERB
cord-011435-x73foqu7	194	3	that	that	SCONJ
cord-011435-x73foqu7	194	4	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	194	5	-	-	PUNCT
cord-011435-x73foqu7	194	6	treated	treat	VERB
cord-011435-x73foqu7	194	7	cells	cell	NOUN
cord-011435-x73foqu7	194	8	exhibited	exhibit	VERB
cord-011435-x73foqu7	194	9	shorter	short	ADJ
cord-011435-x73foqu7	194	10	ubiquitin	ubiquitin	ADJ
cord-011435-x73foqu7	194	11	chains	chain	NOUN
cord-011435-x73foqu7	194	12	linked	link	VERB
cord-011435-x73foqu7	194	13	to	to	ADP
cord-011435-x73foqu7	194	14	irf3	irf3	PROPN
cord-011435-x73foqu7	194	15	than	than	ADP
cord-011435-x73foqu7	194	16	the	the	DET
cord-011435-x73foqu7	194	17	vehicletreated	vehicletreated	ADJ
cord-011435-x73foqu7	194	18	cells	cell	NOUN
cord-011435-x73foqu7	194	19	.	.	PUNCT
cord-011435-x73foqu7	195	1	the	the	DET
cord-011435-x73foqu7	195	2	results	result	NOUN
cord-011435-x73foqu7	195	3	led	lead	VERB
cord-011435-x73foqu7	195	4	us	we	PRON
cord-011435-x73foqu7	195	5	to	to	PART
cord-011435-x73foqu7	195	6	examine	examine	VERB
cord-011435-x73foqu7	195	7	whether	whether	SCONJ
cord-011435-x73foqu7	195	8	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	195	9	increased	increase	VERB
cord-011435-x73foqu7	195	10	the	the	DET
cord-011435-x73foqu7	195	11	rlr	rlr	NOUN
cord-011435-x73foqu7	195	12	-	-	PUNCT
cord-011435-x73foqu7	195	13	induced	induce	VERB
cord-011435-x73foqu7	195	14	release	release	NOUN
cord-011435-x73foqu7	195	15	of	of	ADP
cord-011435-x73foqu7	195	16	cytochrome	cytochrome	NOUN
cord-011435-x73foqu7	195	17	c	c	NOUN
cord-011435-x73foqu7	195	18	into	into	ADP
cord-011435-x73foqu7	195	19	the	the	DET
cord-011435-x73foqu7	195	20	cytosol	cytosol	NOUN
cord-011435-x73foqu7	195	21	(	(	PUNCT
cord-011435-x73foqu7	195	22	stage-2	stage-2	X
cord-011435-x73foqu7	195	23	,	,	PUNCT
cord-011435-x73foqu7	195	24	figure	figure	NOUN
cord-011435-x73foqu7	195	25	1a	1a	NUM
cord-011435-x73foqu7	195	26	)	)	PUNCT
cord-011435-x73foqu7	195	27	,	,	PUNCT
cord-011435-x73foqu7	195	28	a	a	DET
cord-011435-x73foqu7	195	29	step	step	NOUN
cord-011435-x73foqu7	195	30	that	that	PRON
cord-011435-x73foqu7	195	31	requires	require	VERB
cord-011435-x73foqu7	195	32	the	the	DET
cord-011435-x73foqu7	195	33	interaction	interaction	NOUN
cord-011435-x73foqu7	195	34	of	of	ADP
cord-011435-x73foqu7	195	35	irf3	irf3	PROPN
cord-011435-x73foqu7	195	36	and	and	CCONJ
cord-011435-x73foqu7	195	37	bax	bax	PROPN
cord-011435-x73foqu7	195	38	.	.	PROPN
cord-011435-x73foqu7	195	39	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	195	40	did	do	AUX
cord-011435-x73foqu7	195	41	not	not	PART
cord-011435-x73foqu7	195	42	increase	increase	VERB
cord-011435-x73foqu7	195	43	the	the	DET
cord-011435-x73foqu7	195	44	rlr	rlr	VERB
cord-011435-x73foqu7	195	45	-	-	PUNCT
cord-011435-x73foqu7	195	46	induced	induce	VERB
cord-011435-x73foqu7	195	47	release	release	NOUN
cord-011435-x73foqu7	195	48	of	of	ADP
cord-011435-x73foqu7	195	49	cytosolic	cytosolic	ADJ
cord-011435-x73foqu7	195	50	cytochrome	cytochrome	NOUN
cord-011435-x73foqu7	195	51	c	c	NOUN
cord-011435-x73foqu7	196	1	(	(	PUNCT
cord-011435-x73foqu7	196	2	figure	figure	NOUN
cord-011435-x73foqu7	196	3	6b	6b	NUM
cord-011435-x73foqu7	196	4	)	)	PUNCT
cord-011435-x73foqu7	196	5	.	.	PUNCT
cord-011435-x73foqu7	197	1	these	these	DET
cord-011435-x73foqu7	197	2	results	result	NOUN
cord-011435-x73foqu7	197	3	led	lead	VERB
cord-011435-x73foqu7	197	4	us	we	PRON
cord-011435-x73foqu7	197	5	to	to	PART
cord-011435-x73foqu7	197	6	hypothesize	hypothesize	VERB
cord-011435-x73foqu7	197	7	that	that	SCONJ
cord-011435-x73foqu7	197	8	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	197	9	activates	activate	VERB
cord-011435-x73foqu7	197	10	rlr	rlr	NOUN
cord-011435-x73foqu7	197	11	-	-	PUNCT
cord-011435-x73foqu7	197	12	activated	activate	VERB
cord-011435-x73foqu7	197	13	cellular	cellular	ADJ
cord-011435-x73foqu7	197	14	signaling	signaling	NOUN
cord-011435-x73foqu7	197	15	to	to	PART
cord-011435-x73foqu7	197	16	promote	promote	VERB
cord-011435-x73foqu7	197	17	ripa	ripa	PROPN
cord-011435-x73foqu7	197	18	.	.	PUNCT
cord-011435-x73foqu7	198	1	a	a	DET
cord-011435-x73foqu7	198	2	previous	previous	ADJ
cord-011435-x73foqu7	198	3	study	study	NOUN
cord-011435-x73foqu7	198	4	indicated	indicate	VERB
cord-011435-x73foqu7	198	5	that	that	SCONJ
cord-011435-x73foqu7	198	6	p53	p53	NOUN
cord-011435-x73foqu7	198	7	,	,	PUNCT
cord-011435-x73foqu7	198	8	which	which	PRON
cord-011435-x73foqu7	198	9	can	can	AUX
cord-011435-x73foqu7	198	10	be	be	AUX
cord-011435-x73foqu7	198	11	activated	activate	VERB
cord-011435-x73foqu7	198	12	by	by	ADP
cord-011435-x73foqu7	198	13	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	198	14	[	[	PUNCT
cord-011435-x73foqu7	198	15	24	24	NUM
cord-011435-x73foqu7	198	16	]	]	PUNCT
cord-011435-x73foqu7	198	17	,	,	PUNCT
cord-011435-x73foqu7	198	18	is	be	AUX
cord-011435-x73foqu7	198	19	not	not	PART
cord-011435-x73foqu7	198	20	involved	involve	VERB
cord-011435-x73foqu7	198	21	in	in	ADP
cord-011435-x73foqu7	198	22	rlr	rlr	NOUN
cord-011435-x73foqu7	198	23	-	-	PUNCT
cord-011435-x73foqu7	198	24	induced	induce	VERB
cord-011435-x73foqu7	198	25	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	198	26	[	[	X
cord-011435-x73foqu7	198	27	31	31	NUM
cord-011435-x73foqu7	198	28	]	]	PUNCT
cord-011435-x73foqu7	198	29	.	.	PUNCT
cord-011435-x73foqu7	199	1	therefore	therefore	ADV
cord-011435-x73foqu7	199	2	,	,	PUNCT
cord-011435-x73foqu7	199	3	we	we	PRON
cord-011435-x73foqu7	199	4	examined	examine	VERB
cord-011435-x73foqu7	199	5	the	the	DET
cord-011435-x73foqu7	199	6	c	c	PROPN
cord-011435-x73foqu7	199	7	-	-	PUNCT
cord-011435-x73foqu7	199	8	jun	jun	PROPN
cord-011435-x73foqu7	199	9	n	n	ADJ
cord-011435-x73foqu7	199	10	-	-	ADJ
cord-011435-x73foqu7	199	11	terminal	terminal	ADJ
cord-011435-x73foqu7	199	12	kinase	kinase	NOUN
cord-011435-x73foqu7	199	13	(	(	PUNCT
cord-011435-x73foqu7	199	14	jnk	jnk	PROPN
cord-011435-x73foqu7	199	15	)	)	PUNCT
cord-011435-x73foqu7	199	16	and	and	CCONJ
cord-011435-x73foqu7	199	17	extracellular	extracellular	ADJ
cord-011435-x73foqu7	199	18	signal	signal	NOUN
cord-011435-x73foqu7	199	19	-	-	PUNCT
cord-011435-x73foqu7	199	20	regulated	regulate	VERB
cord-011435-x73foqu7	199	21	kinase	kinase	NOUN
cord-011435-x73foqu7	199	22	(	(	PUNCT
cord-011435-x73foqu7	199	23	erk	erk	PROPN
cord-011435-x73foqu7	199	24	)	)	PUNCT
cord-011435-x73foqu7	199	25	signaling	signal	VERB
cord-011435-x73foqu7	199	26	pathways	pathway	NOUN
cord-011435-x73foqu7	199	27	,	,	PUNCT
cord-011435-x73foqu7	199	28	which	which	PRON
cord-011435-x73foqu7	199	29	are	be	AUX
cord-011435-x73foqu7	199	30	activated	activate	VERB
cord-011435-x73foqu7	199	31	upon	upon	SCONJ
cord-011435-x73foqu7	199	32	rlr	rlr	NOUN
cord-011435-x73foqu7	199	33	stimulation	stimulation	NOUN
cord-011435-x73foqu7	199	34	[	[	PUNCT
cord-011435-x73foqu7	199	35	32	32	NUM
cord-011435-x73foqu7	199	36	,	,	PUNCT
cord-011435-x73foqu7	199	37	33	33	NUM
cord-011435-x73foqu7	199	38	]	]	PUNCT
cord-011435-x73foqu7	199	39	.	.	PUNCT
cord-011435-x73foqu7	200	1	rlr	rlr	NOUN
cord-011435-x73foqu7	200	2	stimulation	stimulation	NOUN
cord-011435-x73foqu7	200	3	triggered	trigger	VERB
cord-011435-x73foqu7	200	4	the	the	DET
cord-011435-x73foqu7	200	5	phosphorylation	phosphorylation	NOUN
cord-011435-x73foqu7	200	6	of	of	ADP
cord-011435-x73foqu7	200	7	jnk	jnk	PROPN
cord-011435-x73foqu7	200	8	(	(	PUNCT
cord-011435-x73foqu7	200	9	pjnk	pjnk	PROPN
cord-011435-x73foqu7	200	10	)	)	PUNCT
cord-011435-x73foqu7	200	11	and	and	CCONJ
cord-011435-x73foqu7	200	12	erk	erk	PROPN
cord-011435-x73foqu7	200	13	(	(	PUNCT
cord-011435-x73foqu7	200	14	perk	perk	NOUN
cord-011435-x73foqu7	200	15	)	)	PUNCT
cord-011435-x73foqu7	200	16	,	,	PUNCT
cord-011435-x73foqu7	200	17	which	which	PRON
cord-011435-x73foqu7	200	18	were	be	AUX
cord-011435-x73foqu7	200	19	enhanced	enhance	VERB
cord-011435-x73foqu7	200	20	by	by	ADP
cord-011435-x73foqu7	200	21	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	200	22	(	(	PUNCT
cord-011435-x73foqu7	200	23	figure	figure	NOUN
cord-011435-x73foqu7	200	24	6c	6c	PROPN
cord-011435-x73foqu7	200	25	,	,	PUNCT
cord-011435-x73foqu7	200	26	d	d	NOUN
cord-011435-x73foqu7	200	27	)	)	PUNCT
cord-011435-x73foqu7	200	28	.	.	PUNCT
cord-011435-x73foqu7	201	1	we	we	PRON
cord-011435-x73foqu7	201	2	then	then	ADV
cord-011435-x73foqu7	201	3	tested	test	VERB
cord-011435-x73foqu7	201	4	whether	whether	SCONJ
cord-011435-x73foqu7	201	5	doxorubicinactivated	doxorubicinactivate	VERB
cord-011435-x73foqu7	201	6	jnk	jnk	PROPN
cord-011435-x73foqu7	201	7	and	and	CCONJ
cord-011435-x73foqu7	201	8	erk	erk	PROPN
cord-011435-x73foqu7	201	9	are	be	AUX
cord-011435-x73foqu7	201	10	involved	involve	VERB
cord-011435-x73foqu7	201	11	in	in	ADP
cord-011435-x73foqu7	201	12	promoting	promote	VERB
cord-011435-x73foqu7	201	13	ripa	ripa	NOUN
cord-011435-x73foqu7	201	14	,	,	PUNCT
cord-011435-x73foqu7	201	15	using	use	VERB
cord-011435-x73foqu7	201	16	pharmacological	pharmacological	ADJ
cord-011435-x73foqu7	201	17	inhibitors	inhibitor	NOUN
cord-011435-x73foqu7	201	18	of	of	ADP
cord-011435-x73foqu7	201	19	jnk	jnk	PROPN
cord-011435-x73foqu7	201	20	and	and	CCONJ
cord-011435-x73foqu7	201	21	mitogen	mitogen	PROPN
cord-011435-x73foqu7	201	22	-	-	PUNCT
cord-011435-x73foqu7	201	23	activated	activate	VERB
cord-011435-x73foqu7	201	24	protein	protein	NOUN
cord-011435-x73foqu7	201	25	kinase	kinase	NOUN
cord-011435-x73foqu7	201	26	kinase	kinase	NOUN
cord-011435-x73foqu7	201	27	(	(	PUNCT
cord-011435-x73foqu7	201	28	mek	mek	PROPN
cord-011435-x73foqu7	201	29	)	)	PUNCT
cord-011435-x73foqu7	201	30	,	,	PUNCT
cord-011435-x73foqu7	201	31	the	the	DET
cord-011435-x73foqu7	201	32	upstream	upstream	ADJ
cord-011435-x73foqu7	201	33	activator	activator	NOUN
cord-011435-x73foqu7	201	34	of	of	ADP
cord-011435-x73foqu7	201	35	erk	erk	PROPN
cord-011435-x73foqu7	201	36	.	.	PUNCT
cord-011435-x73foqu7	202	1	inhibition	inhibition	NOUN
cord-011435-x73foqu7	202	2	of	of	ADP
cord-011435-x73foqu7	202	3	mek	mek	PROPN
cord-011435-x73foqu7	202	4	(	(	PUNCT
cord-011435-x73foqu7	202	5	u0126	u0126	PROPN
cord-011435-x73foqu7	202	6	,	,	PUNCT
cord-011435-x73foqu7	202	7	meki	meki	PROPN
cord-011435-x73foqu7	202	8	)	)	PUNCT
cord-011435-x73foqu7	202	9	,	,	PUNCT
cord-011435-x73foqu7	202	10	but	but	CCONJ
cord-011435-x73foqu7	202	11	not	not	PART
cord-011435-x73foqu7	202	12	jnk	jnk	PROPN
cord-011435-x73foqu7	202	13	(	(	PUNCT
cord-011435-x73foqu7	202	14	sp600125	sp600125	PROPN
cord-011435-x73foqu7	202	15	,	,	PUNCT
cord-011435-x73foqu7	202	16	jnki	jnki	PROPN
cord-011435-x73foqu7	202	17	)	)	PUNCT
cord-011435-x73foqu7	202	18	,	,	PUNCT
cord-011435-x73foqu7	202	19	significantly	significantly	ADV
cord-011435-x73foqu7	202	20	suppressed	suppress	VERB
cord-011435-x73foqu7	202	21	doxorubicin	doxorubicin	NOUN
cord-011435-x73foqu7	202	22	-	-	PUNCT
cord-011435-x73foqu7	202	23	promoted	promote	VERB
cord-011435-x73foqu7	202	24	ripa	ripa	NOUN
cord-011435-x73foqu7	202	25	(	(	PUNCT
cord-011435-x73foqu7	202	26	figure	figure	NOUN
cord-011435-x73foqu7	202	27	6e	6e	PROPN
cord-011435-x73foqu7	202	28	)	)	PUNCT
cord-011435-x73foqu7	202	29	.	.	PUNCT
cord-011435-x73foqu7	203	1	we	we	PRON
cord-011435-x73foqu7	203	2	further	far	ADV
cord-011435-x73foqu7	203	3	validated	validate	VERB
cord-011435-x73foqu7	203	4	the	the	DET
cord-011435-x73foqu7	203	5	role	role	NOUN
cord-011435-x73foqu7	203	6	of	of	ADP
cord-011435-x73foqu7	203	7	erk	erk	NOUN
cord-011435-x73foqu7	203	8	in	in	ADP
cord-011435-x73foqu7	203	9	mouse	mouse	NOUN
cord-011435-x73foqu7	203	10	cells	cell	NOUN
cord-011435-x73foqu7	203	11	expressing	express	VERB
cord-011435-x73foqu7	203	12	the	the	DET
cord-011435-x73foqu7	203	13	nt	nt	PROPN
cord-011435-x73foqu7	203	14	-	-	PUNCT
cord-011435-x73foqu7	203	15	irf3	irf3	PROPN
cord-011435-x73foqu7	203	16	mutant	mutant	NOUN
cord-011435-x73foqu7	203	17	(	(	PUNCT
cord-011435-x73foqu7	203	18	irf3	irf3	PROPN
cord-011435-x73foqu7	203	19	s1	s1	PROPN
cord-011435-x73foqu7	203	20	/	/	SYM
cord-011435-x73foqu7	203	21	s1	s1	PROPN
cord-011435-x73foqu7	203	22	)	)	PUNCT
cord-011435-x73foqu7	203	23	,	,	PUNCT
cord-011435-x73foqu7	203	24	which	which	PRON
cord-011435-x73foqu7	203	25	is	be	AUX
cord-011435-x73foqu7	203	26	active	active	ADJ
cord-011435-x73foqu7	203	27	in	in	ADP
cord-011435-x73foqu7	203	28	ripa	ripa	NOUN
cord-011435-x73foqu7	203	29	[	[	X
cord-011435-x73foqu7	203	30	7	7	NUM
cord-011435-x73foqu7	203	31	]	]	PUNCT
cord-011435-x73foqu7	203	32	.	.	PUNCT
cord-011435-x73foqu7	204	1	in	in	ADP
cord-011435-x73foqu7	204	2	irf3	irf3	PROPN
cord-011435-x73foqu7	204	3	s1	s1	PROPN
cord-011435-x73foqu7	204	4	/	/	SYM
cord-011435-x73foqu7	204	5	s1	s1	PROPN
cord-011435-x73foqu7	204	6	mefs	mef	NOUN
cord-011435-x73foqu7	204	7	,	,	PUNCT
cord-011435-x73foqu7	204	8	the	the	DET
cord-011435-x73foqu7	204	9	mek	mek	PROPN
cord-011435-x73foqu7	204	10	inhibitor	inhibitor	NOUN
cord-011435-x73foqu7	204	11	suppressed	suppress	VERB
cord-011435-x73foqu7	204	12	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	204	13	to	to	PART
cord-011435-x73foqu7	204	14	investigate	investigate	VERB
cord-011435-x73foqu7	204	15	the	the	DET
cord-011435-x73foqu7	204	16	biochemical	biochemical	ADJ
cord-011435-x73foqu7	204	17	mechanism	mechanism	NOUN
cord-011435-x73foqu7	204	18	by	by	ADP
cord-011435-x73foqu7	204	19	which	which	PRON
cord-011435-x73foqu7	204	20	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	204	21	promotes	promote	VERB
cord-011435-x73foqu7	204	22	ripa	ripa	PROPN
cord-011435-x73foqu7	204	23	,	,	PUNCT
cord-011435-x73foqu7	204	24	we	we	PRON
cord-011435-x73foqu7	204	25	examined	examine	VERB
cord-011435-x73foqu7	204	26	whether	whether	SCONJ
cord-011435-x73foqu7	204	27	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	204	28	activates	activate	VERB
cord-011435-x73foqu7	204	29	any	any	DET
cord-011435-x73foqu7	204	30	specific	specific	ADJ
cord-011435-x73foqu7	204	31	step(s	step(s	NOUN
cord-011435-x73foqu7	204	32	)	)	PUNCT
cord-011435-x73foqu7	204	33	of	of	ADP
cord-011435-x73foqu7	204	34	ripa	ripa	PROPN
cord-011435-x73foqu7	204	35	(	(	PUNCT
cord-011435-x73foqu7	204	36	depicted	depict	VERB
cord-011435-x73foqu7	204	37	in	in	ADP
cord-011435-x73foqu7	204	38	figure	figure	NOUN
cord-011435-x73foqu7	204	39	1a	1a	NUM
cord-011435-x73foqu7	204	40	)	)	PUNCT
cord-011435-x73foqu7	204	41	.	.	PUNCT
cord-011435-x73foqu7	205	1	we	we	PRON
cord-011435-x73foqu7	205	2	systematically	systematically	ADV
cord-011435-x73foqu7	205	3	analyzed	analyze	VERB
cord-011435-x73foqu7	205	4	both	both	PRON
cord-011435-x73foqu7	205	5	pre	pre	ADJ
cord-011435-x73foqu7	205	6	-	-	ADJ
cord-011435-x73foqu7	205	7	and	and	CCONJ
cord-011435-x73foqu7	205	8	postmitochondrial	postmitochondrial	ADJ
cord-011435-x73foqu7	205	9	steps	step	NOUN
cord-011435-x73foqu7	205	10	of	of	ADP
cord-011435-x73foqu7	205	11	ripa	ripa	NOUN
cord-011435-x73foqu7	205	12	.	.	PUNCT
cord-011435-x73foqu7	206	1	the	the	DET
cord-011435-x73foqu7	206	2	ubiquitination	ubiquitination	NOUN
cord-011435-x73foqu7	206	3	of	of	ADP
cord-011435-x73foqu7	206	4	irf3	irf3	PROPN
cord-011435-x73foqu7	206	5	(	(	PUNCT
cord-011435-x73foqu7	206	6	stage-1	stage-1	PROPN
cord-011435-x73foqu7	206	7	,	,	PUNCT
cord-011435-x73foqu7	206	8	figure	figure	VERB
cord-011435-x73foqu7	206	9	1a	1a	NUM
cord-011435-x73foqu7	206	10	)	)	PUNCT
cord-011435-x73foqu7	206	11	,	,	PUNCT
cord-011435-x73foqu7	206	12	which	which	PRON
cord-011435-x73foqu7	206	13	is	be	AUX
cord-011435-x73foqu7	206	14	essential	essential	ADJ
cord-011435-x73foqu7	206	15	for	for	ADP
cord-011435-x73foqu7	206	16	activating	activate	VERB
cord-011435-x73foqu7	206	17	ripa	ripa	NOUN
cord-011435-x73foqu7	206	18	,	,	PUNCT
cord-011435-x73foqu7	206	19	was	be	AUX
cord-011435-x73foqu7	206	20	not	not	PART
cord-011435-x73foqu7	206	21	promoted	promote	VERB
cord-011435-x73foqu7	206	22	by	by	ADP
cord-011435-x73foqu7	206	23	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	206	24	(	(	PUNCT
cord-011435-x73foqu7	206	25	figure	figure	VERB
cord-011435-x73foqu7	206	26	6a	6a	NOUN
cord-011435-x73foqu7	206	27	)	)	PUNCT
cord-011435-x73foqu7	206	28	.	.	PUNCT
cord-011435-x73foqu7	207	1	we	we	PRON
cord-011435-x73foqu7	207	2	noted	note	VERB
cord-011435-x73foqu7	207	3	that	that	SCONJ
cord-011435-x73foqu7	207	4	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	207	5	-	-	PUNCT
cord-011435-x73foqu7	207	6	treated	treat	VERB
cord-011435-x73foqu7	207	7	cells	cell	NOUN
cord-011435-x73foqu7	207	8	exhibited	exhibit	VERB
cord-011435-x73foqu7	207	9	shorter	short	ADJ
cord-011435-x73foqu7	207	10	ubiquitin	ubiquitin	ADJ
cord-011435-x73foqu7	207	11	chains	chain	NOUN
cord-011435-x73foqu7	207	12	linked	link	VERB
cord-011435-x73foqu7	207	13	to	to	ADP
cord-011435-x73foqu7	207	14	irf3	irf3	PROPN
cord-011435-x73foqu7	207	15	than	than	ADP
cord-011435-x73foqu7	207	16	the	the	DET
cord-011435-x73foqu7	207	17	vehicle	vehicle	NOUN
cord-011435-x73foqu7	207	18	-	-	PUNCT
cord-011435-x73foqu7	207	19	treated	treat	VERB
cord-011435-x73foqu7	207	20	cells	cell	NOUN
cord-011435-x73foqu7	207	21	.	.	PUNCT
cord-011435-x73foqu7	208	1	the	the	DET
cord-011435-x73foqu7	208	2	results	result	NOUN
cord-011435-x73foqu7	208	3	led	lead	VERB
cord-011435-x73foqu7	208	4	us	we	PRON
cord-011435-x73foqu7	208	5	to	to	PART
cord-011435-x73foqu7	208	6	examine	examine	VERB
cord-011435-x73foqu7	208	7	whether	whether	SCONJ
cord-011435-x73foqu7	208	8	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	208	9	increased	increase	VERB
cord-011435-x73foqu7	208	10	the	the	DET
cord-011435-x73foqu7	208	11	rlr	rlr	NOUN
cord-011435-x73foqu7	208	12	-	-	PUNCT
cord-011435-x73foqu7	208	13	induced	induce	VERB
cord-011435-x73foqu7	208	14	release	release	NOUN
cord-011435-x73foqu7	208	15	of	of	ADP
cord-011435-x73foqu7	208	16	cytochrome	cytochrome	NOUN
cord-011435-x73foqu7	208	17	c	c	NOUN
cord-011435-x73foqu7	208	18	into	into	ADP
cord-011435-x73foqu7	208	19	the	the	DET
cord-011435-x73foqu7	208	20	cytosol	cytosol	NOUN
cord-011435-x73foqu7	208	21	(	(	PUNCT
cord-011435-x73foqu7	208	22	stage-2	stage-2	X
cord-011435-x73foqu7	208	23	,	,	PUNCT
cord-011435-x73foqu7	208	24	figure	figure	NOUN
cord-011435-x73foqu7	208	25	1a	1a	NUM
cord-011435-x73foqu7	208	26	)	)	PUNCT
cord-011435-x73foqu7	208	27	,	,	PUNCT
cord-011435-x73foqu7	208	28	a	a	DET
cord-011435-x73foqu7	208	29	step	step	NOUN
cord-011435-x73foqu7	208	30	that	that	PRON
cord-011435-x73foqu7	208	31	requires	require	VERB
cord-011435-x73foqu7	208	32	the	the	DET
cord-011435-x73foqu7	208	33	interaction	interaction	NOUN
cord-011435-x73foqu7	208	34	of	of	ADP
cord-011435-x73foqu7	208	35	irf3	irf3	PROPN
cord-011435-x73foqu7	208	36	and	and	CCONJ
cord-011435-x73foqu7	208	37	bax	bax	PROPN
cord-011435-x73foqu7	208	38	.	.	PROPN
cord-011435-x73foqu7	208	39	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	208	40	did	do	AUX
cord-011435-x73foqu7	208	41	not	not	PART
cord-011435-x73foqu7	208	42	increase	increase	VERB
cord-011435-x73foqu7	208	43	the	the	DET
cord-011435-x73foqu7	208	44	rlr	rlr	VERB
cord-011435-x73foqu7	208	45	-	-	PUNCT
cord-011435-x73foqu7	208	46	induced	induce	VERB
cord-011435-x73foqu7	208	47	release	release	NOUN
cord-011435-x73foqu7	208	48	of	of	ADP
cord-011435-x73foqu7	208	49	cytosolic	cytosolic	ADJ
cord-011435-x73foqu7	208	50	cytochrome	cytochrome	NOUN
cord-011435-x73foqu7	208	51	c	c	NOUN
cord-011435-x73foqu7	209	1	(	(	PUNCT
cord-011435-x73foqu7	209	2	figure	figure	NOUN
cord-011435-x73foqu7	209	3	6b	6b	NUM
cord-011435-x73foqu7	209	4	)	)	PUNCT
cord-011435-x73foqu7	209	5	.	.	PUNCT
cord-011435-x73foqu7	210	1	these	these	DET
cord-011435-x73foqu7	210	2	results	result	NOUN
cord-011435-x73foqu7	210	3	led	lead	VERB
cord-011435-x73foqu7	210	4	us	we	PRON
cord-011435-x73foqu7	210	5	to	to	PART
cord-011435-x73foqu7	210	6	hypothesize	hypothesize	VERB
cord-011435-x73foqu7	210	7	that	that	SCONJ
cord-011435-x73foqu7	210	8	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	210	9	activates	activate	VERB
cord-011435-x73foqu7	210	10	rlr	rlr	NOUN
cord-011435-x73foqu7	210	11	-	-	PUNCT
cord-011435-x73foqu7	210	12	activated	activate	VERB
cord-011435-x73foqu7	210	13	cellular	cellular	ADJ
cord-011435-x73foqu7	210	14	signaling	signaling	NOUN
cord-011435-x73foqu7	210	15	to	to	PART
cord-011435-x73foqu7	210	16	promote	promote	VERB
cord-011435-x73foqu7	210	17	ripa	ripa	PROPN
cord-011435-x73foqu7	210	18	.	.	PUNCT
cord-011435-x73foqu7	211	1	a	a	DET
cord-011435-x73foqu7	211	2	previous	previous	ADJ
cord-011435-x73foqu7	211	3	study	study	NOUN
cord-011435-x73foqu7	211	4	indicated	indicate	VERB
cord-011435-x73foqu7	211	5	that	that	SCONJ
cord-011435-x73foqu7	211	6	p53	p53	NOUN
cord-011435-x73foqu7	211	7	,	,	PUNCT
cord-011435-x73foqu7	211	8	which	which	PRON
cord-011435-x73foqu7	211	9	can	can	AUX
cord-011435-x73foqu7	211	10	be	be	AUX
cord-011435-x73foqu7	211	11	activated	activate	VERB
cord-011435-x73foqu7	211	12	by	by	ADP
cord-011435-x73foqu7	211	13	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	211	14	[	[	PUNCT
cord-011435-x73foqu7	211	15	24	24	NUM
cord-011435-x73foqu7	211	16	]	]	PUNCT
cord-011435-x73foqu7	211	17	,	,	PUNCT
cord-011435-x73foqu7	211	18	is	be	AUX
cord-011435-x73foqu7	211	19	not	not	PART
cord-011435-x73foqu7	211	20	involved	involve	VERB
cord-011435-x73foqu7	211	21	in	in	ADP
cord-011435-x73foqu7	211	22	rlr	rlr	NOUN
cord-011435-x73foqu7	211	23	-	-	PUNCT
cord-011435-x73foqu7	211	24	induced	induce	VERB
cord-011435-x73foqu7	211	25	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	211	26	[	[	X
cord-011435-x73foqu7	211	27	31	31	NUM
cord-011435-x73foqu7	211	28	]	]	PUNCT
cord-011435-x73foqu7	211	29	.	.	PUNCT
cord-011435-x73foqu7	212	1	therefore	therefore	ADV
cord-011435-x73foqu7	212	2	,	,	PUNCT
cord-011435-x73foqu7	212	3	we	we	PRON
cord-011435-x73foqu7	212	4	examined	examine	VERB
cord-011435-x73foqu7	212	5	the	the	DET
cord-011435-x73foqu7	212	6	c	c	PROPN
cord-011435-x73foqu7	212	7	-	-	PUNCT
cord-011435-x73foqu7	212	8	jun	jun	PROPN
cord-011435-x73foqu7	212	9	n	n	ADJ
cord-011435-x73foqu7	212	10	-	-	ADJ
cord-011435-x73foqu7	212	11	terminal	terminal	ADJ
cord-011435-x73foqu7	212	12	kinase	kinase	NOUN
cord-011435-x73foqu7	212	13	(	(	PUNCT
cord-011435-x73foqu7	212	14	jnk	jnk	PROPN
cord-011435-x73foqu7	212	15	)	)	PUNCT
cord-011435-x73foqu7	212	16	and	and	CCONJ
cord-011435-x73foqu7	212	17	extracellular	extracellular	ADJ
cord-011435-x73foqu7	212	18	signal	signal	NOUN
cord-011435-x73foqu7	212	19	-	-	PUNCT
cord-011435-x73foqu7	212	20	regulated	regulate	VERB
cord-011435-x73foqu7	212	21	kinase	kinase	NOUN
cord-011435-x73foqu7	212	22	(	(	PUNCT
cord-011435-x73foqu7	212	23	erk	erk	PROPN
cord-011435-x73foqu7	212	24	)	)	PUNCT
cord-011435-x73foqu7	212	25	signaling	signal	VERB
cord-011435-x73foqu7	212	26	pathways	pathway	NOUN
cord-011435-x73foqu7	212	27	,	,	PUNCT
cord-011435-x73foqu7	212	28	which	which	PRON
cord-011435-x73foqu7	212	29	are	be	AUX
cord-011435-x73foqu7	212	30	activated	activate	VERB
cord-011435-x73foqu7	212	31	upon	upon	SCONJ
cord-011435-x73foqu7	212	32	rlr	rlr	NOUN
cord-011435-x73foqu7	212	33	stimulation	stimulation	NOUN
cord-011435-x73foqu7	212	34	[	[	PUNCT
cord-011435-x73foqu7	212	35	32	32	NUM
cord-011435-x73foqu7	212	36	,	,	PUNCT
cord-011435-x73foqu7	212	37	33	33	NUM
cord-011435-x73foqu7	212	38	]	]	PUNCT
cord-011435-x73foqu7	212	39	.	.	PUNCT
cord-011435-x73foqu7	213	1	rlr	rlr	NOUN
cord-011435-x73foqu7	213	2	stimulation	stimulation	NOUN
cord-011435-x73foqu7	213	3	triggered	trigger	VERB
cord-011435-x73foqu7	213	4	the	the	DET
cord-011435-x73foqu7	213	5	phosphorylation	phosphorylation	NOUN
cord-011435-x73foqu7	213	6	of	of	ADP
cord-011435-x73foqu7	213	7	jnk	jnk	PROPN
cord-011435-x73foqu7	213	8	(	(	PUNCT
cord-011435-x73foqu7	213	9	pjnk	pjnk	PROPN
cord-011435-x73foqu7	213	10	)	)	PUNCT
cord-011435-x73foqu7	213	11	and	and	CCONJ
cord-011435-x73foqu7	213	12	erk	erk	PROPN
cord-011435-x73foqu7	213	13	(	(	PUNCT
cord-011435-x73foqu7	213	14	perk	perk	NOUN
cord-011435-x73foqu7	213	15	)	)	PUNCT
cord-011435-x73foqu7	213	16	,	,	PUNCT
cord-011435-x73foqu7	213	17	which	which	PRON
cord-011435-x73foqu7	213	18	were	be	AUX
cord-011435-x73foqu7	213	19	enhanced	enhance	VERB
cord-011435-x73foqu7	213	20	by	by	ADP
cord-011435-x73foqu7	213	21	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	213	22	(	(	PUNCT
cord-011435-x73foqu7	213	23	figure	figure	NOUN
cord-011435-x73foqu7	213	24	6c	6c	PROPN
cord-011435-x73foqu7	213	25	,	,	PUNCT
cord-011435-x73foqu7	213	26	d	d	NOUN
cord-011435-x73foqu7	213	27	)	)	PUNCT
cord-011435-x73foqu7	213	28	.	.	PUNCT
cord-011435-x73foqu7	214	1	we	we	PRON
cord-011435-x73foqu7	214	2	then	then	ADV
cord-011435-x73foqu7	214	3	tested	test	VERB
cord-011435-x73foqu7	214	4	whether	whether	SCONJ
cord-011435-x73foqu7	214	5	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	214	6	-	-	PUNCT
cord-011435-x73foqu7	214	7	activated	activate	VERB
cord-011435-x73foqu7	214	8	jnk	jnk	PROPN
cord-011435-x73foqu7	214	9	and	and	CCONJ
cord-011435-x73foqu7	214	10	erk	erk	PROPN
cord-011435-x73foqu7	214	11	are	be	AUX
cord-011435-x73foqu7	214	12	involved	involve	VERB
cord-011435-x73foqu7	214	13	in	in	ADP
cord-011435-x73foqu7	214	14	promoting	promote	VERB
cord-011435-x73foqu7	214	15	ripa	ripa	NOUN
cord-011435-x73foqu7	214	16	,	,	PUNCT
cord-011435-x73foqu7	214	17	using	use	VERB
cord-011435-x73foqu7	214	18	pharmacological	pharmacological	ADJ
cord-011435-x73foqu7	214	19	inhibitors	inhibitor	NOUN
cord-011435-x73foqu7	214	20	of	of	ADP
cord-011435-x73foqu7	214	21	jnk	jnk	PROPN
cord-011435-x73foqu7	214	22	and	and	CCONJ
cord-011435-x73foqu7	214	23	mitogen	mitogen	PROPN
cord-011435-x73foqu7	214	24	-	-	PUNCT
cord-011435-x73foqu7	214	25	activated	activate	VERB
cord-011435-x73foqu7	214	26	protein	protein	NOUN
cord-011435-x73foqu7	214	27	kinase	kinase	NOUN
cord-011435-x73foqu7	214	28	kinase	kinase	NOUN
cord-011435-x73foqu7	214	29	(	(	PUNCT
cord-011435-x73foqu7	214	30	mek	mek	PROPN
cord-011435-x73foqu7	214	31	)	)	PUNCT
cord-011435-x73foqu7	214	32	,	,	PUNCT
cord-011435-x73foqu7	214	33	the	the	DET
cord-011435-x73foqu7	214	34	upstream	upstream	ADJ
cord-011435-x73foqu7	214	35	activator	activator	NOUN
cord-011435-x73foqu7	214	36	of	of	ADP
cord-011435-x73foqu7	214	37	erk	erk	PROPN
cord-011435-x73foqu7	214	38	.	.	PUNCT
cord-011435-x73foqu7	215	1	inhibition	inhibition	NOUN
cord-011435-x73foqu7	215	2	of	of	ADP
cord-011435-x73foqu7	215	3	mek	mek	PROPN
cord-011435-x73foqu7	215	4	(	(	PUNCT
cord-011435-x73foqu7	215	5	u0126	u0126	PROPN
cord-011435-x73foqu7	215	6	,	,	PUNCT
cord-011435-x73foqu7	215	7	mek	mek	PROPN
cord-011435-x73foqu7	215	8	i	i	PROPN
cord-011435-x73foqu7	215	9	)	)	PUNCT
cord-011435-x73foqu7	215	10	,	,	PUNCT
cord-011435-x73foqu7	215	11	but	but	CCONJ
cord-011435-x73foqu7	215	12	not	not	PART
cord-011435-x73foqu7	215	13	jnk	jnk	PROPN
cord-011435-x73foqu7	215	14	(	(	PUNCT
cord-011435-x73foqu7	215	15	sp600125	sp600125	PROPN
cord-011435-x73foqu7	215	16	,	,	PUNCT
cord-011435-x73foqu7	215	17	jnk	jnk	PROPN
cord-011435-x73foqu7	215	18	i	i	PROPN
cord-011435-x73foqu7	215	19	)	)	PUNCT
cord-011435-x73foqu7	215	20	,	,	PUNCT
cord-011435-x73foqu7	215	21	significantly	significantly	ADV
cord-011435-x73foqu7	215	22	suppressed	suppress	VERB
cord-011435-x73foqu7	215	23	doxorubicin	doxorubicin	NOUN
cord-011435-x73foqu7	215	24	-	-	PUNCT
cord-011435-x73foqu7	215	25	promoted	promote	VERB
cord-011435-x73foqu7	215	26	ripa	ripa	NOUN
cord-011435-x73foqu7	215	27	(	(	PUNCT
cord-011435-x73foqu7	215	28	figure	figure	NOUN
cord-011435-x73foqu7	215	29	6e	6e	PROPN
cord-011435-x73foqu7	215	30	)	)	PUNCT
cord-011435-x73foqu7	215	31	.	.	PUNCT
cord-011435-x73foqu7	216	1	we	we	PRON
cord-011435-x73foqu7	216	2	further	far	ADV
cord-011435-x73foqu7	216	3	validated	validate	VERB
cord-011435-x73foqu7	216	4	the	the	DET
cord-011435-x73foqu7	216	5	role	role	NOUN
cord-011435-x73foqu7	216	6	of	of	ADP
cord-011435-x73foqu7	216	7	erk	erk	NOUN
cord-011435-x73foqu7	216	8	in	in	ADP
cord-011435-x73foqu7	216	9	mouse	mouse	NOUN
cord-011435-x73foqu7	216	10	cells	cell	NOUN
cord-011435-x73foqu7	216	11	expressing	express	VERB
cord-011435-x73foqu7	216	12	the	the	DET
cord-011435-x73foqu7	216	13	nt	nt	PROPN
cord-011435-x73foqu7	216	14	-	-	PUNCT
cord-011435-x73foqu7	216	15	irf3	irf3	PROPN
cord-011435-x73foqu7	216	16	mutant	mutant	NOUN
cord-011435-x73foqu7	216	17	(	(	PUNCT
cord-011435-x73foqu7	216	18	irf3	irf3	PROPN
cord-011435-x73foqu7	216	19	s1	s1	PROPN
cord-011435-x73foqu7	216	20	/	/	SYM
cord-011435-x73foqu7	216	21	s1	s1	PROPN
cord-011435-x73foqu7	216	22	)	)	PUNCT
cord-011435-x73foqu7	216	23	,	,	PUNCT
cord-011435-x73foqu7	216	24	which	which	PRON
cord-011435-x73foqu7	216	25	is	be	AUX
cord-011435-x73foqu7	216	26	active	active	ADJ
cord-011435-x73foqu7	216	27	in	in	ADP
cord-011435-x73foqu7	216	28	ripa	ripa	NOUN
cord-011435-x73foqu7	216	29	[	[	X
cord-011435-x73foqu7	216	30	7	7	NUM
cord-011435-x73foqu7	216	31	]	]	PUNCT
cord-011435-x73foqu7	216	32	.	.	PUNCT
cord-011435-x73foqu7	217	1	in	in	ADP
cord-011435-x73foqu7	217	2	irf3	irf3	PROPN
cord-011435-x73foqu7	217	3	s1	s1	PROPN
cord-011435-x73foqu7	217	4	/	/	SYM
cord-011435-x73foqu7	217	5	s1	s1	PROPN
cord-011435-x73foqu7	217	6	mefs	mef	NOUN
cord-011435-x73foqu7	217	7	,	,	PUNCT
cord-011435-x73foqu7	217	8	the	the	DET
cord-011435-x73foqu7	217	9	mek	mek	PROPN
cord-011435-x73foqu7	217	10	inhibitor	inhibitor	NOUN
cord-011435-x73foqu7	217	11	suppressed	suppress	VERB
cord-011435-x73foqu7	217	12	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	217	13	-	-	PUNCT
cord-011435-x73foqu7	217	14	promoted	promote	VERB
cord-011435-x73foqu7	217	15	ripa	ripa	NOUN
cord-011435-x73foqu7	217	16	,	,	PUNCT
cord-011435-x73foqu7	217	17	analyzed	analyze	VERB
cord-011435-x73foqu7	217	18	by	by	ADP
cord-011435-x73foqu7	217	19	rlr	rlr	NOUN
cord-011435-x73foqu7	217	20	-	-	PUNCT
cord-011435-x73foqu7	217	21	induced	induce	VERB
cord-011435-x73foqu7	217	22	caspase-3	caspase-3	PROPN
cord-011435-x73foqu7	217	23	activity	activity	NOUN
cord-011435-x73foqu7	217	24	(	(	PUNCT
cord-011435-x73foqu7	217	25	figure	figure	NOUN
cord-011435-x73foqu7	217	26	6f	6f	NUM
cord-011435-x73foqu7	217	27	)	)	PUNCT
cord-011435-x73foqu7	217	28	and	and	CCONJ
cord-011435-x73foqu7	217	29	c	c	NOUN
cord-011435-x73foqu7	217	30	-	-	NOUN
cord-011435-x73foqu7	217	31	parp	parp	NOUN
cord-011435-x73foqu7	217	32	(	(	PUNCT
cord-011435-x73foqu7	217	33	figure	figure	NOUN
cord-011435-x73foqu7	217	34	6	6	NUM
cord-011435-x73foqu7	217	35	g	g	NOUN
cord-011435-x73foqu7	217	36	)	)	PUNCT
cord-011435-x73foqu7	217	37	.	.	PUNCT
cord-011435-x73foqu7	218	1	together	together	ADV
cord-011435-x73foqu7	218	2	,	,	PUNCT
cord-011435-x73foqu7	218	3	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	218	4	-	-	PUNCT
cord-011435-x73foqu7	218	5	activated	activate	VERB
cord-011435-x73foqu7	218	6	erk	erk	PROPN
cord-011435-x73foqu7	218	7	signaling	signaling	NOUN
cord-011435-x73foqu7	218	8	is	be	AUX
cord-011435-x73foqu7	218	9	involved	involve	VERB
cord-011435-x73foqu7	218	10	in	in	ADP
cord-011435-x73foqu7	218	11	promoting	promote	VERB
cord-011435-x73foqu7	218	12	ripa	ripa	PROPN
cord-011435-x73foqu7	218	13	.	.	PUNCT
cord-011435-x73foqu7	219	1	viruses	virus	NOUN
cord-011435-x73foqu7	219	2	2020	2020	NUM
cord-011435-x73foqu7	219	3	,	,	PUNCT
cord-011435-x73foqu7	219	4	12	12	NUM
cord-011435-x73foqu7	219	5	,	,	PUNCT
cord-011435-x73foqu7	219	6	x	x	X
cord-011435-x73foqu7	219	7	for	for	ADP
cord-011435-x73foqu7	219	8	peer	peer	NOUN
cord-011435-x73foqu7	219	9	review	review	PROPN
cord-011435-x73foqu7	219	10	11	11	NUM
cord-011435-x73foqu7	219	11	of	of	ADP
cord-011435-x73foqu7	219	12	18	18	NUM
cord-011435-x73foqu7	219	13	promoted	promote	VERB
cord-011435-x73foqu7	219	14	ripa	ripa	NOUN
cord-011435-x73foqu7	219	15	,	,	PUNCT
cord-011435-x73foqu7	219	16	analyzed	analyze	VERB
cord-011435-x73foqu7	219	17	by	by	ADP
cord-011435-x73foqu7	219	18	rlr	rlr	NOUN
cord-011435-x73foqu7	219	19	-	-	PUNCT
cord-011435-x73foqu7	219	20	induced	induce	VERB
cord-011435-x73foqu7	219	21	caspase-3	caspase-3	PROPN
cord-011435-x73foqu7	219	22	activity	activity	NOUN
cord-011435-x73foqu7	219	23	(	(	PUNCT
cord-011435-x73foqu7	219	24	figure	figure	NOUN
cord-011435-x73foqu7	219	25	6f	6f	NUM
cord-011435-x73foqu7	219	26	)	)	PUNCT
cord-011435-x73foqu7	219	27	and	and	CCONJ
cord-011435-x73foqu7	219	28	c	c	NOUN
cord-011435-x73foqu7	219	29	-	-	NOUN
cord-011435-x73foqu7	219	30	parp	parp	NOUN
cord-011435-x73foqu7	219	31	(	(	PUNCT
cord-011435-x73foqu7	219	32	figure	figure	NOUN
cord-011435-x73foqu7	219	33	6	6	NUM
cord-011435-x73foqu7	219	34	g	g	NOUN
cord-011435-x73foqu7	219	35	)	)	PUNCT
cord-011435-x73foqu7	219	36	.	.	PUNCT
cord-011435-x73foqu7	220	1	together	together	ADV
cord-011435-x73foqu7	220	2	,	,	PUNCT
cord-011435-x73foqu7	220	3	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	220	4	-	-	PUNCT
cord-011435-x73foqu7	220	5	activated	activate	VERB
cord-011435-x73foqu7	220	6	erk	erk	PROPN
cord-011435-x73foqu7	220	7	signaling	signaling	NOUN
cord-011435-x73foqu7	220	8	is	be	AUX
cord-011435-x73foqu7	220	9	involved	involve	VERB
cord-011435-x73foqu7	220	10	in	in	ADP
cord-011435-x73foqu7	220	11	promoting	promote	VERB
cord-011435-x73foqu7	220	12	ripa	ripa	PROPN
cord-011435-x73foqu7	220	13	.	.	PUNCT
cord-011435-x73foqu7	221	1	to	to	PART
cord-011435-x73foqu7	221	2	test	test	VERB
cord-011435-x73foqu7	221	3	whether	whether	SCONJ
cord-011435-x73foqu7	221	4	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	221	5	inhibits	inhibit	VERB
cord-011435-x73foqu7	221	6	viruses	virus	NOUN
cord-011435-x73foqu7	221	7	of	of	ADP
cord-011435-x73foqu7	221	8	other	other	ADJ
cord-011435-x73foqu7	221	9	families	family	NOUN
cord-011435-x73foqu7	221	10	,	,	PUNCT
cord-011435-x73foqu7	221	11	we	we	PRON
cord-011435-x73foqu7	221	12	used	use	VERB
cord-011435-x73foqu7	221	13	members	member	NOUN
cord-011435-x73foqu7	221	14	of	of	ADP
cord-011435-x73foqu7	221	15	flaviviridae	flaviviridae	PROPN
cord-011435-x73foqu7	221	16	and	and	CCONJ
cord-011435-x73foqu7	221	17	herpesviridae	herpesviridae	PROPN
cord-011435-x73foqu7	221	18	,	,	PUNCT
cord-011435-x73foqu7	221	19	which	which	PRON
cord-011435-x73foqu7	221	20	are	be	AUX
cord-011435-x73foqu7	221	21	known	know	VERB
cord-011435-x73foqu7	221	22	to	to	PART
cord-011435-x73foqu7	221	23	activate	activate	VERB
cord-011435-x73foqu7	221	24	the	the	DET
cord-011435-x73foqu7	221	25	rlr	rlr	NOUN
cord-011435-x73foqu7	221	26	signaling	signal	VERB
cord-011435-x73foqu7	221	27	pathway	pathway	NOUN
cord-011435-x73foqu7	221	28	[	[	X
cord-011435-x73foqu7	221	29	34	34	NUM
cord-011435-x73foqu7	221	30	]	]	PUNCT
cord-011435-x73foqu7	221	31	[	[	X
cord-011435-x73foqu7	221	32	35	35	NUM
cord-011435-x73foqu7	221	33	]	]	PUNCT
cord-011435-x73foqu7	221	34	[	[	X
cord-011435-x73foqu7	221	35	36	36	NUM
cord-011435-x73foqu7	221	36	]	]	PUNCT
cord-011435-x73foqu7	221	37	.	.	PUNCT
cord-011435-x73foqu7	222	1	we	we	PRON
cord-011435-x73foqu7	222	2	previously	previously	ADV
cord-011435-x73foqu7	222	3	demonstrated	demonstrate	VERB
cord-011435-x73foqu7	222	4	that	that	SCONJ
cord-011435-x73foqu7	222	5	ripa	ripa	NOUN
cord-011435-x73foqu7	222	6	can	can	AUX
cord-011435-x73foqu7	222	7	be	be	AUX
cord-011435-x73foqu7	222	8	activated	activate	VERB
cord-011435-x73foqu7	222	9	by	by	ADP
cord-011435-x73foqu7	222	10	viruses	virus	NOUN
cord-011435-x73foqu7	222	11	with	with	ADP
cord-011435-x73foqu7	222	12	positive	positive	ADJ
cord-011435-x73foqu7	222	13	-	-	PUNCT
cord-011435-x73foqu7	222	14	sense	sense	NOUN
cord-011435-x73foqu7	222	15	rna	rna	NOUN
cord-011435-x73foqu7	222	16	or	or	CCONJ
cord-011435-x73foqu7	222	17	dna	dna	NOUN
cord-011435-x73foqu7	222	18	genomes	genome	NOUN
cord-011435-x73foqu7	222	19	[	[	X
cord-011435-x73foqu7	222	20	13	13	NUM
cord-011435-x73foqu7	222	21	]	]	PUNCT
cord-011435-x73foqu7	222	22	.	.	PUNCT
cord-011435-x73foqu7	223	1	consistent	consistent	ADJ
cord-011435-x73foqu7	223	2	with	with	ADP
cord-011435-x73foqu7	223	3	the	the	DET
cord-011435-x73foqu7	223	4	vsv	vsv	NOUN
cord-011435-x73foqu7	223	5	results	result	NOUN
cord-011435-x73foqu7	223	6	(	(	PUNCT
cord-011435-x73foqu7	223	7	figure	figure	NOUN
cord-011435-x73foqu7	223	8	3	3	NUM
cord-011435-x73foqu7	223	9	)	)	PUNCT
cord-011435-x73foqu7	223	10	,	,	PUNCT
cord-011435-x73foqu7	223	11	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	223	12	treatment	treatment	NOUN
cord-011435-x73foqu7	223	13	inhibited	inhibit	VERB
cord-011435-x73foqu7	223	14	langat	langat	NOUN
cord-011435-x73foqu7	223	15	virus	virus	NOUN
cord-011435-x73foqu7	223	16	(	(	PUNCT
cord-011435-x73foqu7	223	17	lgtv	lgtv	X
cord-011435-x73foqu7	223	18	)	)	PUNCT
cord-011435-x73foqu7	224	1	(	(	PUNCT
cord-011435-x73foqu7	224	2	figure	figure	NOUN
cord-011435-x73foqu7	224	3	7a	7a	NUM
cord-011435-x73foqu7	224	4	)	)	PUNCT
cord-011435-x73foqu7	224	5	and	and	CCONJ
cord-011435-x73foqu7	224	6	kunjin	kunjin	PROPN
cord-011435-x73foqu7	224	7	virus	virus	PROPN
cord-011435-x73foqu7	224	8	(	(	PUNCT
cord-011435-x73foqu7	224	9	kunv	kunv	PROPN
cord-011435-x73foqu7	224	10	)	)	PUNCT
cord-011435-x73foqu7	225	1	(	(	PUNCT
cord-011435-x73foqu7	225	2	figure	figure	NOUN
cord-011435-x73foqu7	225	3	7b	7b	NUM
cord-011435-x73foqu7	225	4	)	)	PUNCT
cord-011435-x73foqu7	225	5	infectious	infectious	ADJ
cord-011435-x73foqu7	225	6	virion	virion	NOUN
cord-011435-x73foqu7	225	7	production	production	NOUN
cord-011435-x73foqu7	225	8	.	.	PUNCT
cord-011435-x73foqu7	226	1	furthermore	furthermore	ADV
cord-011435-x73foqu7	226	2	,	,	PUNCT
cord-011435-x73foqu7	226	3	cytosolic	cytosolic	ADJ
cord-011435-x73foqu7	226	4	dna	dna	NOUN
cord-011435-x73foqu7	226	5	from	from	ADP
cord-011435-x73foqu7	226	6	dna	dna	PROPN
cord-011435-x73foqu7	226	7	viruses	virus	NOUN
cord-011435-x73foqu7	226	8	can	can	AUX
cord-011435-x73foqu7	226	9	activate	activate	VERB
cord-011435-x73foqu7	226	10	ripa	ripa	NOUN
cord-011435-x73foqu7	226	11	through	through	ADP
cord-011435-x73foqu7	226	12	rna	rna	PROPN
cord-011435-x73foqu7	226	13	polymerase	polymerase	NOUN
cord-011435-x73foqu7	226	14	iii	iii	NUM
cord-011435-x73foqu7	226	15	activity	activity	NOUN
cord-011435-x73foqu7	226	16	[	[	PUNCT
cord-011435-x73foqu7	226	17	13	13	NUM
cord-011435-x73foqu7	226	18	]	]	PUNCT
cord-011435-x73foqu7	226	19	.	.	PUNCT
cord-011435-x73foqu7	227	1	to	to	PART
cord-011435-x73foqu7	227	2	investigate	investigate	VERB
cord-011435-x73foqu7	227	3	whether	whether	SCONJ
cord-011435-x73foqu7	227	4	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	227	5	also	also	ADV
cord-011435-x73foqu7	227	6	inhibits	inhibit	VERB
cord-011435-x73foqu7	227	7	dna	dna	PROPN
cord-011435-x73foqu7	227	8	virus	virus	NOUN
cord-011435-x73foqu7	227	9	replication	replication	NOUN
cord-011435-x73foqu7	227	10	,	,	PUNCT
cord-011435-x73foqu7	227	11	we	we	PRON
cord-011435-x73foqu7	227	12	used	use	VERB
cord-011435-x73foqu7	227	13	two	two	NUM
cord-011435-x73foqu7	227	14	strains	strain	NOUN
cord-011435-x73foqu7	227	15	(	(	PUNCT
cord-011435-x73foqu7	227	16	kos	kos	PROPN
cord-011435-x73foqu7	227	17	and	and	CCONJ
cord-011435-x73foqu7	227	18	f	f	PROPN
cord-011435-x73foqu7	227	19	)	)	PUNCT
cord-011435-x73foqu7	227	20	of	of	ADP
cord-011435-x73foqu7	227	21	hsv-1	hsv-1	PROPN
cord-011435-x73foqu7	227	22	.	.	PROPN
cord-011435-x73foqu7	228	1	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	228	2	strongly	strongly	ADV
cord-011435-x73foqu7	228	3	inhibited	inhibit	VERB
cord-011435-x73foqu7	228	4	hsv-1	hsv-1	PUNCT
cord-011435-x73foqu7	228	5	(	(	PUNCT
cord-011435-x73foqu7	228	6	kos	kos	PROPN
cord-011435-x73foqu7	228	7	strain	strain	PROPN
cord-011435-x73foqu7	228	8	)	)	PUNCT
cord-011435-x73foqu7	228	9	replication	replication	NOUN
cord-011435-x73foqu7	228	10	,	,	PUNCT
cord-011435-x73foqu7	228	11	indicated	indicate	VERB
cord-011435-x73foqu7	228	12	by	by	ADP
cord-011435-x73foqu7	228	13	the	the	DET
cord-011435-x73foqu7	228	14	reduction	reduction	NOUN
cord-011435-x73foqu7	228	15	in	in	ADP
cord-011435-x73foqu7	228	16	icp0	icp0	NOUN
cord-011435-x73foqu7	228	17	expression	expression	NOUN
cord-011435-x73foqu7	228	18	by	by	ADP
cord-011435-x73foqu7	228	19	immunoblot	immunoblot	NOUN
cord-011435-x73foqu7	228	20	(	(	PUNCT
cord-011435-x73foqu7	228	21	figure	figure	NOUN
cord-011435-x73foqu7	228	22	7c	7c	NUM
cord-011435-x73foqu7	228	23	)	)	PUNCT
cord-011435-x73foqu7	228	24	and	and	CCONJ
cord-011435-x73foqu7	228	25	confocal	confocal	ADJ
cord-011435-x73foqu7	228	26	microscopy	microscopy	NOUN
cord-011435-x73foqu7	228	27	(	(	PUNCT
cord-011435-x73foqu7	228	28	figure	figure	NOUN
cord-011435-x73foqu7	228	29	7d	7d	NUM
cord-011435-x73foqu7	228	30	)	)	PUNCT
cord-011435-x73foqu7	228	31	.	.	PUNCT
cord-011435-x73foqu7	229	1	the	the	DET
cord-011435-x73foqu7	229	2	inhibition	inhibition	NOUN
cord-011435-x73foqu7	229	3	of	of	ADP
cord-011435-x73foqu7	229	4	viral	viral	ADJ
cord-011435-x73foqu7	229	5	protein	protein	NOUN
cord-011435-x73foqu7	229	6	expression	expression	NOUN
cord-011435-x73foqu7	229	7	led	lead	VERB
cord-011435-x73foqu7	229	8	to	to	ADP
cord-011435-x73foqu7	229	9	a	a	DET
cord-011435-x73foqu7	229	10	significant	significant	ADJ
cord-011435-x73foqu7	229	11	reduction	reduction	NOUN
cord-011435-x73foqu7	229	12	in	in	ADP
cord-011435-x73foqu7	229	13	infectious	infectious	ADJ
cord-011435-x73foqu7	229	14	virus	virus	NOUN
cord-011435-x73foqu7	229	15	particle	particle	NOUN
cord-011435-x73foqu7	229	16	release	release	NOUN
cord-011435-x73foqu7	229	17	from	from	ADP
cord-011435-x73foqu7	229	18	the	the	DET
cord-011435-x73foqu7	229	19	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	229	20	-	-	PUNCT
cord-011435-x73foqu7	229	21	treated	treat	VERB
cord-011435-x73foqu7	229	22	cells	cell	NOUN
cord-011435-x73foqu7	229	23	(	(	PUNCT
cord-011435-x73foqu7	229	24	figure	figure	VERB
cord-011435-x73foqu7	229	25	7e	7e	PROPN
cord-011435-x73foqu7	229	26	)	)	PUNCT
cord-011435-x73foqu7	229	27	.	.	PUNCT
cord-011435-x73foqu7	230	1	similar	similar	ADJ
cord-011435-x73foqu7	230	2	to	to	ADP
cord-011435-x73foqu7	230	3	the	the	DET
cord-011435-x73foqu7	230	4	kos	kos	PROPN
cord-011435-x73foqu7	230	5	strain	strain	NOUN
cord-011435-x73foqu7	230	6	,	,	PUNCT
cord-011435-x73foqu7	230	7	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	230	8	also	also	ADV
cord-011435-x73foqu7	230	9	inhibited	inhibit	VERB
cord-011435-x73foqu7	230	10	the	the	DET
cord-011435-x73foqu7	230	11	replication	replication	NOUN
cord-011435-x73foqu7	230	12	of	of	ADP
cord-011435-x73foqu7	230	13	hsv-1	hsv-1	PUNCT
cord-011435-x73foqu7	230	14	f	f	PROPN
cord-011435-x73foqu7	230	15	strain	strain	NOUN
cord-011435-x73foqu7	230	16	(	(	PUNCT
cord-011435-x73foqu7	230	17	figure	figure	NOUN
cord-011435-x73foqu7	230	18	7f	7f	NOUN
cord-011435-x73foqu7	230	19	)	)	PUNCT
cord-011435-x73foqu7	230	20	.	.	PUNCT
cord-011435-x73foqu7	231	1	collectively	collectively	ADV
cord-011435-x73foqu7	231	2	,	,	PUNCT
cord-011435-x73foqu7	231	3	our	our	PRON
cord-011435-x73foqu7	231	4	results	result	NOUN
cord-011435-x73foqu7	231	5	demonstrate	demonstrate	VERB
cord-011435-x73foqu7	231	6	that	that	SCONJ
cord-011435-x73foqu7	231	7	the	the	DET
cord-011435-x73foqu7	231	8	ripapromoting	ripapromote	VERB
cord-011435-x73foqu7	231	9	agent	agent	NOUN
cord-011435-x73foqu7	231	10	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	231	11	inhibits	inhibit	VERB
cord-011435-x73foqu7	231	12	the	the	DET
cord-011435-x73foqu7	231	13	replication	replication	NOUN
cord-011435-x73foqu7	231	14	of	of	ADP
cord-011435-x73foqu7	231	15	both	both	DET
cord-011435-x73foqu7	231	16	rna	rna	NOUN
cord-011435-x73foqu7	231	17	and	and	CCONJ
cord-011435-x73foqu7	231	18	dna	dna	PROPN
cord-011435-x73foqu7	231	19	viruses	virus	NOUN
cord-011435-x73foqu7	231	20	.	.	PUNCT
cord-011435-x73foqu7	232	1	to	to	PART
cord-011435-x73foqu7	232	2	test	test	VERB
cord-011435-x73foqu7	232	3	whether	whether	SCONJ
cord-011435-x73foqu7	232	4	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	232	5	inhibits	inhibit	VERB
cord-011435-x73foqu7	232	6	viruses	virus	NOUN
cord-011435-x73foqu7	232	7	of	of	ADP
cord-011435-x73foqu7	232	8	other	other	ADJ
cord-011435-x73foqu7	232	9	families	family	NOUN
cord-011435-x73foqu7	232	10	,	,	PUNCT
cord-011435-x73foqu7	232	11	we	we	PRON
cord-011435-x73foqu7	232	12	used	use	VERB
cord-011435-x73foqu7	232	13	members	member	NOUN
cord-011435-x73foqu7	232	14	of	of	ADP
cord-011435-x73foqu7	232	15	flaviviridae	flaviviridae	PROPN
cord-011435-x73foqu7	232	16	and	and	CCONJ
cord-011435-x73foqu7	232	17	herpesviridae	herpesviridae	PROPN
cord-011435-x73foqu7	232	18	,	,	PUNCT
cord-011435-x73foqu7	232	19	which	which	PRON
cord-011435-x73foqu7	232	20	are	be	AUX
cord-011435-x73foqu7	232	21	known	know	VERB
cord-011435-x73foqu7	232	22	to	to	PART
cord-011435-x73foqu7	232	23	activate	activate	VERB
cord-011435-x73foqu7	232	24	the	the	DET
cord-011435-x73foqu7	232	25	rlr	rlr	NOUN
cord-011435-x73foqu7	232	26	signaling	signal	VERB
cord-011435-x73foqu7	232	27	pathway	pathway	NOUN
cord-011435-x73foqu7	232	28	[	[	X
cord-011435-x73foqu7	232	29	34	34	NUM
cord-011435-x73foqu7	232	30	]	]	PUNCT
cord-011435-x73foqu7	232	31	[	[	X
cord-011435-x73foqu7	232	32	35	35	NUM
cord-011435-x73foqu7	232	33	]	]	PUNCT
cord-011435-x73foqu7	232	34	[	[	X
cord-011435-x73foqu7	232	35	36	36	NUM
cord-011435-x73foqu7	232	36	]	]	PUNCT
cord-011435-x73foqu7	232	37	.	.	PUNCT
cord-011435-x73foqu7	233	1	we	we	PRON
cord-011435-x73foqu7	233	2	previously	previously	ADV
cord-011435-x73foqu7	233	3	demonstrated	demonstrate	VERB
cord-011435-x73foqu7	233	4	that	that	SCONJ
cord-011435-x73foqu7	233	5	ripa	ripa	NOUN
cord-011435-x73foqu7	233	6	can	can	AUX
cord-011435-x73foqu7	233	7	be	be	AUX
cord-011435-x73foqu7	233	8	activated	activate	VERB
cord-011435-x73foqu7	233	9	by	by	ADP
cord-011435-x73foqu7	233	10	viruses	virus	NOUN
cord-011435-x73foqu7	233	11	with	with	ADP
cord-011435-x73foqu7	233	12	positive	positive	ADJ
cord-011435-x73foqu7	233	13	-	-	PUNCT
cord-011435-x73foqu7	233	14	sense	sense	NOUN
cord-011435-x73foqu7	233	15	rna	rna	NOUN
cord-011435-x73foqu7	233	16	or	or	CCONJ
cord-011435-x73foqu7	233	17	dna	dna	NOUN
cord-011435-x73foqu7	233	18	genomes	genome	NOUN
cord-011435-x73foqu7	233	19	[	[	X
cord-011435-x73foqu7	233	20	13	13	NUM
cord-011435-x73foqu7	233	21	]	]	PUNCT
cord-011435-x73foqu7	233	22	.	.	PUNCT
cord-011435-x73foqu7	234	1	consistent	consistent	ADJ
cord-011435-x73foqu7	234	2	with	with	ADP
cord-011435-x73foqu7	234	3	the	the	DET
cord-011435-x73foqu7	234	4	vsv	vsv	NOUN
cord-011435-x73foqu7	234	5	results	result	NOUN
cord-011435-x73foqu7	234	6	(	(	PUNCT
cord-011435-x73foqu7	234	7	figure	figure	NOUN
cord-011435-x73foqu7	234	8	3	3	NUM
cord-011435-x73foqu7	234	9	)	)	PUNCT
cord-011435-x73foqu7	234	10	,	,	PUNCT
cord-011435-x73foqu7	234	11	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	234	12	treatment	treatment	NOUN
cord-011435-x73foqu7	234	13	inhibited	inhibit	VERB
cord-011435-x73foqu7	234	14	langat	langat	NOUN
cord-011435-x73foqu7	234	15	virus	virus	NOUN
cord-011435-x73foqu7	234	16	(	(	PUNCT
cord-011435-x73foqu7	234	17	lgtv	lgtv	X
cord-011435-x73foqu7	234	18	)	)	PUNCT
cord-011435-x73foqu7	235	1	(	(	PUNCT
cord-011435-x73foqu7	235	2	figure	figure	NOUN
cord-011435-x73foqu7	235	3	7a	7a	NUM
cord-011435-x73foqu7	235	4	)	)	PUNCT
cord-011435-x73foqu7	235	5	and	and	CCONJ
cord-011435-x73foqu7	235	6	kunjin	kunjin	PROPN
cord-011435-x73foqu7	235	7	virus	virus	PROPN
cord-011435-x73foqu7	235	8	(	(	PUNCT
cord-011435-x73foqu7	235	9	kunv	kunv	PROPN
cord-011435-x73foqu7	235	10	)	)	PUNCT
cord-011435-x73foqu7	236	1	(	(	PUNCT
cord-011435-x73foqu7	236	2	figure	figure	NOUN
cord-011435-x73foqu7	236	3	7b	7b	NUM
cord-011435-x73foqu7	236	4	)	)	PUNCT
cord-011435-x73foqu7	236	5	infectious	infectious	ADJ
cord-011435-x73foqu7	236	6	virion	virion	NOUN
cord-011435-x73foqu7	236	7	production	production	NOUN
cord-011435-x73foqu7	236	8	.	.	PUNCT
cord-011435-x73foqu7	237	1	furthermore	furthermore	ADV
cord-011435-x73foqu7	237	2	,	,	PUNCT
cord-011435-x73foqu7	237	3	cytosolic	cytosolic	ADJ
cord-011435-x73foqu7	237	4	dna	dna	NOUN
cord-011435-x73foqu7	237	5	from	from	ADP
cord-011435-x73foqu7	237	6	dna	dna	PROPN
cord-011435-x73foqu7	237	7	viruses	virus	NOUN
cord-011435-x73foqu7	237	8	can	can	AUX
cord-011435-x73foqu7	237	9	activate	activate	VERB
cord-011435-x73foqu7	237	10	ripa	ripa	NOUN
cord-011435-x73foqu7	237	11	through	through	ADP
cord-011435-x73foqu7	237	12	rna	rna	PROPN
cord-011435-x73foqu7	237	13	polymerase	polymerase	NOUN
cord-011435-x73foqu7	237	14	iii	iii	NUM
cord-011435-x73foqu7	237	15	activity	activity	NOUN
cord-011435-x73foqu7	237	16	[	[	PUNCT
cord-011435-x73foqu7	237	17	13	13	NUM
cord-011435-x73foqu7	237	18	]	]	PUNCT
cord-011435-x73foqu7	237	19	.	.	PUNCT
cord-011435-x73foqu7	238	1	to	to	PART
cord-011435-x73foqu7	238	2	investigate	investigate	VERB
cord-011435-x73foqu7	238	3	whether	whether	SCONJ
cord-011435-x73foqu7	238	4	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	238	5	also	also	ADV
cord-011435-x73foqu7	238	6	inhibits	inhibit	VERB
cord-011435-x73foqu7	238	7	dna	dna	PROPN
cord-011435-x73foqu7	238	8	virus	virus	NOUN
cord-011435-x73foqu7	238	9	replication	replication	NOUN
cord-011435-x73foqu7	238	10	,	,	PUNCT
cord-011435-x73foqu7	238	11	we	we	PRON
cord-011435-x73foqu7	238	12	used	use	VERB
cord-011435-x73foqu7	238	13	two	two	NUM
cord-011435-x73foqu7	238	14	strains	strain	NOUN
cord-011435-x73foqu7	238	15	(	(	PUNCT
cord-011435-x73foqu7	238	16	kos	kos	PROPN
cord-011435-x73foqu7	238	17	and	and	CCONJ
cord-011435-x73foqu7	238	18	f	f	PROPN
cord-011435-x73foqu7	238	19	)	)	PUNCT
cord-011435-x73foqu7	238	20	of	of	ADP
cord-011435-x73foqu7	238	21	hsv-1	hsv-1	PROPN
cord-011435-x73foqu7	238	22	.	.	PROPN
cord-011435-x73foqu7	239	1	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	239	2	strongly	strongly	ADV
cord-011435-x73foqu7	239	3	inhibited	inhibit	VERB
cord-011435-x73foqu7	239	4	hsv-1	hsv-1	PUNCT
cord-011435-x73foqu7	239	5	(	(	PUNCT
cord-011435-x73foqu7	239	6	kos	kos	PROPN
cord-011435-x73foqu7	239	7	strain	strain	PROPN
cord-011435-x73foqu7	239	8	)	)	PUNCT
cord-011435-x73foqu7	239	9	replication	replication	NOUN
cord-011435-x73foqu7	239	10	,	,	PUNCT
cord-011435-x73foqu7	239	11	indicated	indicate	VERB
cord-011435-x73foqu7	239	12	by	by	ADP
cord-011435-x73foqu7	239	13	the	the	DET
cord-011435-x73foqu7	239	14	reduction	reduction	NOUN
cord-011435-x73foqu7	239	15	in	in	ADP
cord-011435-x73foqu7	239	16	icp0	icp0	NOUN
cord-011435-x73foqu7	239	17	expression	expression	NOUN
cord-011435-x73foqu7	239	18	by	by	ADP
cord-011435-x73foqu7	239	19	immunoblot	immunoblot	NOUN
cord-011435-x73foqu7	239	20	(	(	PUNCT
cord-011435-x73foqu7	239	21	figure	figure	NOUN
cord-011435-x73foqu7	239	22	7c	7c	NUM
cord-011435-x73foqu7	239	23	)	)	PUNCT
cord-011435-x73foqu7	239	24	and	and	CCONJ
cord-011435-x73foqu7	239	25	confocal	confocal	ADJ
cord-011435-x73foqu7	239	26	microscopy	microscopy	NOUN
cord-011435-x73foqu7	239	27	(	(	PUNCT
cord-011435-x73foqu7	239	28	figure	figure	NOUN
cord-011435-x73foqu7	239	29	7d	7d	NUM
cord-011435-x73foqu7	239	30	)	)	PUNCT
cord-011435-x73foqu7	239	31	.	.	PUNCT
cord-011435-x73foqu7	240	1	the	the	DET
cord-011435-x73foqu7	240	2	inhibition	inhibition	NOUN
cord-011435-x73foqu7	240	3	of	of	ADP
cord-011435-x73foqu7	240	4	viral	viral	ADJ
cord-011435-x73foqu7	240	5	protein	protein	NOUN
cord-011435-x73foqu7	240	6	expression	expression	NOUN
cord-011435-x73foqu7	240	7	led	lead	VERB
cord-011435-x73foqu7	240	8	to	to	ADP
cord-011435-x73foqu7	240	9	a	a	DET
cord-011435-x73foqu7	240	10	significant	significant	ADJ
cord-011435-x73foqu7	240	11	reduction	reduction	NOUN
cord-011435-x73foqu7	240	12	in	in	ADP
cord-011435-x73foqu7	240	13	infectious	infectious	ADJ
cord-011435-x73foqu7	240	14	virus	virus	NOUN
cord-011435-x73foqu7	240	15	particle	particle	NOUN
cord-011435-x73foqu7	240	16	release	release	NOUN
cord-011435-x73foqu7	240	17	from	from	ADP
cord-011435-x73foqu7	240	18	the	the	DET
cord-011435-x73foqu7	240	19	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	240	20	-	-	PUNCT
cord-011435-x73foqu7	240	21	treated	treat	VERB
cord-011435-x73foqu7	240	22	cells	cell	NOUN
cord-011435-x73foqu7	240	23	(	(	PUNCT
cord-011435-x73foqu7	240	24	figure	figure	VERB
cord-011435-x73foqu7	240	25	7e	7e	PROPN
cord-011435-x73foqu7	240	26	)	)	PUNCT
cord-011435-x73foqu7	240	27	.	.	PUNCT
cord-011435-x73foqu7	241	1	similar	similar	ADJ
cord-011435-x73foqu7	241	2	to	to	ADP
cord-011435-x73foqu7	241	3	the	the	DET
cord-011435-x73foqu7	241	4	kos	kos	PROPN
cord-011435-x73foqu7	241	5	strain	strain	NOUN
cord-011435-x73foqu7	241	6	,	,	PUNCT
cord-011435-x73foqu7	241	7	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	241	8	also	also	ADV
cord-011435-x73foqu7	241	9	inhibited	inhibit	VERB
cord-011435-x73foqu7	241	10	the	the	DET
cord-011435-x73foqu7	241	11	replication	replication	NOUN
cord-011435-x73foqu7	241	12	of	of	ADP
cord-011435-x73foqu7	241	13	hsv-1	hsv-1	PUNCT
cord-011435-x73foqu7	241	14	f	f	PROPN
cord-011435-x73foqu7	241	15	strain	strain	NOUN
cord-011435-x73foqu7	241	16	(	(	PUNCT
cord-011435-x73foqu7	241	17	figure	figure	NOUN
cord-011435-x73foqu7	241	18	7f	7f	NOUN
cord-011435-x73foqu7	241	19	)	)	PUNCT
cord-011435-x73foqu7	241	20	.	.	PUNCT
cord-011435-x73foqu7	242	1	collectively	collectively	ADV
cord-011435-x73foqu7	242	2	,	,	PUNCT
cord-011435-x73foqu7	242	3	our	our	PRON
cord-011435-x73foqu7	242	4	results	result	NOUN
cord-011435-x73foqu7	242	5	demonstrate	demonstrate	VERB
cord-011435-x73foqu7	242	6	that	that	SCONJ
cord-011435-x73foqu7	242	7	the	the	DET
cord-011435-x73foqu7	242	8	ripa	ripa	ADV
cord-011435-x73foqu7	242	9	-	-	PUNCT
cord-011435-x73foqu7	242	10	promoting	promote	VERB
cord-011435-x73foqu7	242	11	agent	agent	NOUN
cord-011435-x73foqu7	242	12	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	242	13	inhibits	inhibit	VERB
cord-011435-x73foqu7	242	14	the	the	DET
cord-011435-x73foqu7	242	15	replication	replication	NOUN
cord-011435-x73foqu7	242	16	of	of	ADP
cord-011435-x73foqu7	242	17	both	both	DET
cord-011435-x73foqu7	242	18	rna	rna	NOUN
cord-011435-x73foqu7	242	19	and	and	CCONJ
cord-011435-x73foqu7	242	20	dna	dna	PROPN
cord-011435-x73foqu7	242	21	viruses	virus	NOUN
cord-011435-x73foqu7	242	22	.	.	PUNCT
cord-011435-x73foqu7	243	1	viruses	virus	NOUN
cord-011435-x73foqu7	243	2	2020	2020	NUM
cord-011435-x73foqu7	243	3	,	,	PUNCT
cord-011435-x73foqu7	243	4	12	12	NUM
cord-011435-x73foqu7	243	5	,	,	PUNCT
cord-011435-x73foqu7	243	6	x	x	X
cord-011435-x73foqu7	243	7	for	for	ADP
cord-011435-x73foqu7	243	8	peer	peer	NOUN
cord-011435-x73foqu7	243	9	review	review	PROPN
cord-011435-x73foqu7	243	10	12	12	NUM
cord-011435-x73foqu7	243	11	of	of	ADP
cord-011435-x73foqu7	243	12	18	18	NUM
cord-011435-x73foqu7	243	13	to	to	PART
cord-011435-x73foqu7	243	14	test	test	VERB
cord-011435-x73foqu7	243	15	the	the	DET
cord-011435-x73foqu7	243	16	generality	generality	NOUN
cord-011435-x73foqu7	243	17	of	of	ADP
cord-011435-x73foqu7	243	18	the	the	DET
cord-011435-x73foqu7	243	19	theme	theme	NOUN
cord-011435-x73foqu7	243	20	that	that	PRON
cord-011435-x73foqu7	243	21	ripa	ripa	NOUN
cord-011435-x73foqu7	243	22	-	-	PUNCT
cord-011435-x73foqu7	243	23	promoting	promote	VERB
cord-011435-x73foqu7	243	24	compounds	compound	NOUN
cord-011435-x73foqu7	243	25	are	be	AUX
cord-011435-x73foqu7	243	26	antiviral	antiviral	ADJ
cord-011435-x73foqu7	243	27	agents	agent	NOUN
cord-011435-x73foqu7	243	28	,	,	PUNCT
cord-011435-x73foqu7	243	29	we	we	PRON
cord-011435-x73foqu7	243	30	screened	screen	VERB
cord-011435-x73foqu7	243	31	a	a	DET
cord-011435-x73foqu7	243	32	subset	subset	NOUN
cord-011435-x73foqu7	243	33	of	of	ADP
cord-011435-x73foqu7	243	34	the	the	DET
cord-011435-x73foqu7	243	35	secondary	secondary	ADJ
cord-011435-x73foqu7	243	36	-	-	PUNCT
cord-011435-x73foqu7	243	37	validated	validate	VERB
cord-011435-x73foqu7	243	38	ripa	ripa	NOUN
cord-011435-x73foqu7	243	39	-	-	PUNCT
cord-011435-x73foqu7	243	40	promoters	promoter	NOUN
cord-011435-x73foqu7	243	41	(	(	PUNCT
cord-011435-x73foqu7	243	42	act12	act12	PROPN
cord-011435-x73foqu7	243	43	,	,	PUNCT
cord-011435-x73foqu7	243	44	act2	act2	PROPN
cord-011435-x73foqu7	243	45	,	,	PUNCT
cord-011435-x73foqu7	243	46	act5	act5	PROPN
cord-011435-x73foqu7	243	47	,	,	PUNCT
cord-011435-x73foqu7	243	48	act16	act16	NOUN
cord-011435-x73foqu7	243	49	,	,	PUNCT
cord-011435-x73foqu7	243	50	act9	act9	PROPN
cord-011435-x73foqu7	243	51	,	,	PUNCT
cord-011435-x73foqu7	243	52	and	and	CCONJ
cord-011435-x73foqu7	243	53	act3	act3	PROPN
cord-011435-x73foqu7	243	54	)	)	PUNCT
cord-011435-x73foqu7	243	55	,	,	PUNCT
cord-011435-x73foqu7	243	56	based	base	VERB
cord-011435-x73foqu7	243	57	on	on	ADP
cord-011435-x73foqu7	243	58	an	an	DET
cord-011435-x73foqu7	243	59	arbitrary	arbitrary	ADJ
cord-011435-x73foqu7	243	60	cut	cut	NOUN
cord-011435-x73foqu7	243	61	-	-	PUNCT
cord-011435-x73foqu7	243	62	off	off	NOUN
cord-011435-x73foqu7	243	63	of	of	ADP
cord-011435-x73foqu7	243	64	a	a	DET
cord-011435-x73foqu7	243	65	1.9	1.9	NUM
cord-011435-x73foqu7	243	66	-	-	ADJ
cord-011435-x73foqu7	243	67	fold	fold	ADJ
cord-011435-x73foqu7	243	68	increase	increase	NOUN
cord-011435-x73foqu7	243	69	in	in	ADP
cord-011435-x73foqu7	243	70	ripa	ripa	NOUN
cord-011435-x73foqu7	243	71	-	-	PUNCT
cord-011435-x73foqu7	243	72	promotion	promotion	NOUN
cord-011435-x73foqu7	243	73	(	(	PUNCT
cord-011435-x73foqu7	243	74	figure	figure	NOUN
cord-011435-x73foqu7	243	75	2c	2c	NOUN
cord-011435-x73foqu7	243	76	)	)	PUNCT
cord-011435-x73foqu7	243	77	,	,	PUNCT
cord-011435-x73foqu7	243	78	for	for	ADP
cord-011435-x73foqu7	243	79	their	their	PRON
cord-011435-x73foqu7	243	80	ability	ability	NOUN
cord-011435-x73foqu7	243	81	to	to	PART
cord-011435-x73foqu7	243	82	inhibit	inhibit	VERB
cord-011435-x73foqu7	243	83	hsv-1	hsv-1	PUNCT
cord-011435-x73foqu7	243	84	replication	replication	NOUN
cord-011435-x73foqu7	243	85	(	(	PUNCT
cord-011435-x73foqu7	243	86	figure	figure	NOUN
cord-011435-x73foqu7	243	87	8a	8a	NUM
cord-011435-x73foqu7	243	88	)	)	PUNCT
cord-011435-x73foqu7	243	89	.	.	PUNCT
cord-011435-x73foqu7	244	1	we	we	PRON
cord-011435-x73foqu7	244	2	confirmed	confirm	VERB
cord-011435-x73foqu7	244	3	the	the	DET
cord-011435-x73foqu7	244	4	anti	anti	ADJ
cord-011435-x73foqu7	244	5	-	-	ADJ
cord-011435-x73foqu7	244	6	hsv-1	hsv-1	ADJ
cord-011435-x73foqu7	244	7	activity	activity	NOUN
cord-011435-x73foqu7	244	8	of	of	ADP
cord-011435-x73foqu7	244	9	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	244	10	(	(	PUNCT
cord-011435-x73foqu7	244	11	act9	act9	PROPN
cord-011435-x73foqu7	244	12	)	)	PUNCT
cord-011435-x73foqu7	244	13	,	,	PUNCT
cord-011435-x73foqu7	244	14	and	and	CCONJ
cord-011435-x73foqu7	244	15	also	also	ADV
cord-011435-x73foqu7	244	16	isolated	isolate	VERB
cord-011435-x73foqu7	244	17	two	two	NUM
cord-011435-x73foqu7	244	18	additional	additional	ADJ
cord-011435-x73foqu7	244	19	compounds	compound	NOUN
cord-011435-x73foqu7	244	20	(	(	PUNCT
cord-011435-x73foqu7	244	21	act3	act3	NOUN
cord-011435-x73foqu7	244	22	and	and	CCONJ
cord-011435-x73foqu7	244	23	act5	act5	PROPN
cord-011435-x73foqu7	244	24	)	)	PUNCT
cord-011435-x73foqu7	244	25	that	that	PRON
cord-011435-x73foqu7	244	26	strongly	strongly	ADV
cord-011435-x73foqu7	244	27	inhibited	inhibit	VERB
cord-011435-x73foqu7	244	28	icp0	icp0	NOUN
cord-011435-x73foqu7	244	29	expression	expression	NOUN
cord-011435-x73foqu7	244	30	(	(	PUNCT
cord-011435-x73foqu7	244	31	figure	figure	NOUN
cord-011435-x73foqu7	244	32	8a	8a	NUM
cord-011435-x73foqu7	244	33	)	)	PUNCT
cord-011435-x73foqu7	244	34	.	.	PUNCT
cord-011435-x73foqu7	245	1	we	we	PRON
cord-011435-x73foqu7	245	2	excluded	exclude	VERB
cord-011435-x73foqu7	245	3	act3	act3	ADP
cord-011435-x73foqu7	245	4	(	(	PUNCT
cord-011435-x73foqu7	245	5	topotecan	topotecan	ADJ
cord-011435-x73foqu7	245	6	)	)	PUNCT
cord-011435-x73foqu7	245	7	from	from	ADP
cord-011435-x73foqu7	245	8	further	further	ADJ
cord-011435-x73foqu7	245	9	analyses	analysis	NOUN
cord-011435-x73foqu7	245	10	because	because	SCONJ
cord-011435-x73foqu7	245	11	it	it	PRON
cord-011435-x73foqu7	245	12	shares	share	VERB
cord-011435-x73foqu7	245	13	properties	property	NOUN
cord-011435-x73foqu7	245	14	with	with	ADP
cord-011435-x73foqu7	245	15	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	245	16	and	and	CCONJ
cord-011435-x73foqu7	245	17	may	may	AUX
cord-011435-x73foqu7	245	18	activate	activate	VERB
cord-011435-x73foqu7	245	19	similar	similar	ADJ
cord-011435-x73foqu7	245	20	pathways	pathway	NOUN
cord-011435-x73foqu7	245	21	.	.	PUNCT
cord-011435-x73foqu7	246	1	we	we	PRON
cord-011435-x73foqu7	246	2	focused	focus	VERB
cord-011435-x73foqu7	246	3	on	on	ADP
cord-011435-x73foqu7	246	4	the	the	DET
cord-011435-x73foqu7	246	5	anti	anti	ADJ
cord-011435-x73foqu7	246	6	-	-	ADJ
cord-011435-x73foqu7	246	7	helminthic	helminthic	ADJ
cord-011435-x73foqu7	246	8	drug	drug	NOUN
cord-011435-x73foqu7	246	9	pyrvinium	pyrvinium	ADP
cord-011435-x73foqu7	246	10	pamoate	pamoate	NOUN
cord-011435-x73foqu7	246	11	(	(	PUNCT
cord-011435-x73foqu7	246	12	pp	pp	ADV
cord-011435-x73foqu7	246	13	,	,	PUNCT
cord-011435-x73foqu7	246	14	act5	act5	PROPN
cord-011435-x73foqu7	246	15	)	)	PUNCT
cord-011435-x73foqu7	246	16	for	for	ADP
cord-011435-x73foqu7	246	17	validation	validation	NOUN
cord-011435-x73foqu7	246	18	of	of	ADP
cord-011435-x73foqu7	246	19	our	our	PRON
cord-011435-x73foqu7	246	20	hypothesis	hypothesis	NOUN
cord-011435-x73foqu7	246	21	.	.	PUNCT
cord-011435-x73foqu7	247	1	similar	similar	ADJ
cord-011435-x73foqu7	247	2	to	to	ADP
cord-011435-x73foqu7	247	3	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	247	4	,	,	PUNCT
cord-011435-x73foqu7	247	5	pp	pp	ADV
cord-011435-x73foqu7	247	6	inhibited	inhibit	VERB
cord-011435-x73foqu7	247	7	the	the	DET
cord-011435-x73foqu7	247	8	replication	replication	NOUN
cord-011435-x73foqu7	247	9	of	of	ADP
cord-011435-x73foqu7	247	10	hsv-1	hsv-1	PUNCT
cord-011435-x73foqu7	247	11	in	in	ADP
cord-011435-x73foqu7	247	12	ht1080	ht1080	PROPN
cord-011435-x73foqu7	247	13	cells	cell	NOUN
cord-011435-x73foqu7	247	14	,	,	PUNCT
cord-011435-x73foqu7	247	15	in	in	ADP
cord-011435-x73foqu7	247	16	a	a	DET
cord-011435-x73foqu7	247	17	dose	dose	NOUN
cord-011435-x73foqu7	247	18	-	-	PUNCT
cord-011435-x73foqu7	247	19	dependent	dependent	ADJ
cord-011435-x73foqu7	247	20	manner	manner	NOUN
cord-011435-x73foqu7	247	21	,	,	PUNCT
cord-011435-x73foqu7	247	22	demonstrated	demonstrate	VERB
cord-011435-x73foqu7	247	23	by	by	ADP
cord-011435-x73foqu7	247	24	immunoblot	immunoblot	NOUN
cord-011435-x73foqu7	247	25	of	of	ADP
cord-011435-x73foqu7	247	26	viral	viral	ADJ
cord-011435-x73foqu7	247	27	proteins	protein	NOUN
cord-011435-x73foqu7	247	28	icp0	icp0	NOUN
cord-011435-x73foqu7	247	29	and	and	CCONJ
cord-011435-x73foqu7	247	30	icp8	icp8	PROPN
cord-011435-x73foqu7	247	31	(	(	PUNCT
cord-011435-x73foqu7	247	32	figure	figure	VERB
cord-011435-x73foqu7	247	33	8b	8b	NUM
cord-011435-x73foqu7	247	34	)	)	PUNCT
cord-011435-x73foqu7	247	35	.	.	PUNCT
cord-011435-x73foqu7	248	1	pp	pp	ADV
cord-011435-x73foqu7	248	2	also	also	ADV
cord-011435-x73foqu7	248	3	inhibited	inhibit	VERB
cord-011435-x73foqu7	248	4	vsv	vsv	PROPN
cord-011435-x73foqu7	248	5	replication	replication	PROPN
cord-011435-x73foqu7	248	6	,	,	PUNCT
cord-011435-x73foqu7	248	7	analyzed	analyze	VERB
cord-011435-x73foqu7	248	8	by	by	ADP
cord-011435-x73foqu7	248	9	immunoblot	immunoblot	NOUN
cord-011435-x73foqu7	248	10	of	of	ADP
cord-011435-x73foqu7	248	11	the	the	DET
cord-011435-x73foqu7	248	12	viral	viral	ADJ
cord-011435-x73foqu7	248	13	protein	protein	NOUN
cord-011435-x73foqu7	248	14	vsv	vsv	PROPN
cord-011435-x73foqu7	248	15	-	-	PROPN
cord-011435-x73foqu7	248	16	g	g	NOUN
cord-011435-x73foqu7	248	17	(	(	PUNCT
cord-011435-x73foqu7	248	18	figure	figure	NOUN
cord-011435-x73foqu7	248	19	8c	8c	NUM
cord-011435-x73foqu7	248	20	)	)	PUNCT
cord-011435-x73foqu7	249	1	and	and	CCONJ
cord-011435-x73foqu7	249	2	infectious	infectious	ADJ
cord-011435-x73foqu7	249	3	virion	virion	NOUN
cord-011435-x73foqu7	249	4	particle	particle	NOUN
cord-011435-x73foqu7	249	5	release	release	NOUN
cord-011435-x73foqu7	249	6	(	(	PUNCT
cord-011435-x73foqu7	249	7	figure	figure	NOUN
cord-011435-x73foqu7	249	8	8d	8d	NOUN
cord-011435-x73foqu7	249	9	)	)	PUNCT
cord-011435-x73foqu7	249	10	.	.	PUNCT
cord-011435-x73foqu7	250	1	the	the	DET
cord-011435-x73foqu7	250	2	antiviral	antiviral	ADJ
cord-011435-x73foqu7	250	3	activity	activity	NOUN
cord-011435-x73foqu7	250	4	of	of	ADP
cord-011435-x73foqu7	250	5	pp	pp	PROPN
cord-011435-x73foqu7	250	6	prompted	prompt	VERB
cord-011435-x73foqu7	250	7	us	we	PRON
cord-011435-x73foqu7	250	8	to	to	PART
cord-011435-x73foqu7	250	9	test	test	VERB
cord-011435-x73foqu7	250	10	its	its	PRON
cord-011435-x73foqu7	250	11	ability	ability	NOUN
cord-011435-x73foqu7	250	12	to	to	PART
cord-011435-x73foqu7	250	13	activate	activate	VERB
cord-011435-x73foqu7	250	14	irf3	irf3	PROPN
cord-011435-x73foqu7	250	15	.	.	PUNCT
cord-011435-x73foqu7	251	1	pp	pp	ADV
cord-011435-x73foqu7	251	2	,	,	PUNCT
cord-011435-x73foqu7	251	3	as	as	SCONJ
cord-011435-x73foqu7	251	4	expected	expect	VERB
cord-011435-x73foqu7	251	5	,	,	PUNCT
cord-011435-x73foqu7	251	6	promoted	promote	VERB
cord-011435-x73foqu7	251	7	the	the	DET
cord-011435-x73foqu7	251	8	ripa	ripa	ADJ
cord-011435-x73foqu7	251	9	branch	branch	NOUN
cord-011435-x73foqu7	251	10	of	of	ADP
cord-011435-x73foqu7	251	11	irf3	irf3	PROPN
cord-011435-x73foqu7	251	12	,	,	PUNCT
cord-011435-x73foqu7	251	13	measured	measure	VERB
cord-011435-x73foqu7	251	14	by	by	ADP
cord-011435-x73foqu7	251	15	caspase	caspase	NOUN
cord-011435-x73foqu7	251	16	activity	activity	NOUN
cord-011435-x73foqu7	251	17	(	(	PUNCT
cord-011435-x73foqu7	251	18	figure	figure	NOUN
cord-011435-x73foqu7	251	19	8e	8e	NUM
cord-011435-x73foqu7	251	20	)	)	PUNCT
cord-011435-x73foqu7	251	21	and	and	CCONJ
cord-011435-x73foqu7	251	22	c	c	X
cord-011435-x73foqu7	251	23	-	-	NOUN
cord-011435-x73foqu7	251	24	parp	parp	NOUN
cord-011435-x73foqu7	251	25	(	(	PUNCT
cord-011435-x73foqu7	251	26	figure	figure	NOUN
cord-011435-x73foqu7	251	27	8f	8f	NOUN
cord-011435-x73foqu7	251	28	)	)	PUNCT
cord-011435-x73foqu7	251	29	.	.	PUNCT
cord-011435-x73foqu7	252	1	unlike	unlike	ADP
cord-011435-x73foqu7	252	2	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	252	3	,	,	PUNCT
cord-011435-x73foqu7	252	4	pp	pp	ADJ
cord-011435-x73foqu7	252	5	treatment	treatment	NOUN
cord-011435-x73foqu7	252	6	did	do	AUX
cord-011435-x73foqu7	252	7	not	not	PART
cord-011435-x73foqu7	252	8	trigger	trigger	VERB
cord-011435-x73foqu7	252	9	an	an	DET
cord-011435-x73foqu7	252	10	apoptotic	apoptotic	ADJ
cord-011435-x73foqu7	252	11	pathway	pathway	NOUN
cord-011435-x73foqu7	252	12	in	in	ADP
cord-011435-x73foqu7	252	13	the	the	DET
cord-011435-x73foqu7	252	14	absence	absence	NOUN
cord-011435-x73foqu7	252	15	of	of	ADP
cord-011435-x73foqu7	252	16	rlrstimulation	rlrstimulation	NOUN
cord-011435-x73foqu7	252	17	(	(	PUNCT
cord-011435-x73foqu7	252	18	figure	figure	NOUN
cord-011435-x73foqu7	252	19	8f	8f	PROPN
cord-011435-x73foqu7	252	20	,	,	PUNCT
cord-011435-x73foqu7	252	21	lane	lane	NOUN
cord-011435-x73foqu7	252	22	2	2	NUM
cord-011435-x73foqu7	252	23	)	)	PUNCT
cord-011435-x73foqu7	252	24	.	.	PUNCT
cord-011435-x73foqu7	253	1	to	to	PART
cord-011435-x73foqu7	253	2	investigate	investigate	VERB
cord-011435-x73foqu7	253	3	whether	whether	SCONJ
cord-011435-x73foqu7	253	4	pp	pp	PROPN
cord-011435-x73foqu7	253	5	uses	use	VERB
cord-011435-x73foqu7	253	6	a	a	DET
cord-011435-x73foqu7	253	7	mechanism	mechanism	NOUN
cord-011435-x73foqu7	253	8	similar	similar	ADJ
cord-011435-x73foqu7	253	9	to	to	ADP
cord-011435-x73foqu7	253	10	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	253	11	to	to	PART
cord-011435-x73foqu7	253	12	promote	promote	VERB
cord-011435-x73foqu7	253	13	ripa	ripa	ADJ
cord-011435-x73foqu7	253	14	,	,	PUNCT
cord-011435-x73foqu7	253	15	we	we	PRON
cord-011435-x73foqu7	253	16	tested	test	VERB
cord-011435-x73foqu7	253	17	the	the	DET
cord-011435-x73foqu7	253	18	mek	mek	PROPN
cord-011435-x73foqu7	253	19	inhibitor	inhibitor	NOUN
cord-011435-x73foqu7	253	20	in	in	ADP
cord-011435-x73foqu7	253	21	pp	pp	ADV
cord-011435-x73foqu7	253	22	-	-	PUNCT
cord-011435-x73foqu7	253	23	promoted	promote	VERB
cord-011435-x73foqu7	253	24	ripa	ripa	NOUN
cord-011435-x73foqu7	253	25	.	.	PUNCT
cord-011435-x73foqu7	254	1	inhibition	inhibition	NOUN
cord-011435-x73foqu7	254	2	of	of	ADP
cord-011435-x73foqu7	254	3	mek	mek	PROPN
cord-011435-x73foqu7	254	4	reduced	reduce	VERB
cord-011435-x73foqu7	254	5	rlr	rlr	NOUN
cord-011435-x73foqu7	254	6	-	-	PUNCT
cord-011435-x73foqu7	254	7	induced	induce	VERB
cord-011435-x73foqu7	254	8	c	c	NOUN
cord-011435-x73foqu7	254	9	-	-	NOUN
cord-011435-x73foqu7	254	10	parp	parp	NOUN
cord-011435-x73foqu7	254	11	in	in	ADP
cord-011435-x73foqu7	254	12	pp	pp	ADV
cord-011435-x73foqu7	254	13	-	-	PUNCT
cord-011435-x73foqu7	254	14	treated	treat	VERB
cord-011435-x73foqu7	254	15	cells	cell	NOUN
cord-011435-x73foqu7	254	16	(	(	PUNCT
cord-011435-x73foqu7	254	17	figure	figure	VERB
cord-011435-x73foqu7	254	18	8	8	NUM
cord-011435-x73foqu7	254	19	g	g	NOUN
cord-011435-x73foqu7	254	20	)	)	PUNCT
cord-011435-x73foqu7	254	21	.	.	PUNCT
cord-011435-x73foqu7	255	1	therefore	therefore	ADV
cord-011435-x73foqu7	255	2	,	,	PUNCT
cord-011435-x73foqu7	255	3	erk	erk	PROPN
cord-011435-x73foqu7	255	4	signaling	signaling	NOUN
cord-011435-x73foqu7	255	5	may	may	AUX
cord-011435-x73foqu7	255	6	be	be	AUX
cord-011435-x73foqu7	255	7	a	a	DET
cord-011435-x73foqu7	255	8	common	common	ADJ
cord-011435-x73foqu7	255	9	to	to	PART
cord-011435-x73foqu7	255	10	test	test	VERB
cord-011435-x73foqu7	255	11	the	the	DET
cord-011435-x73foqu7	255	12	generality	generality	NOUN
cord-011435-x73foqu7	255	13	of	of	ADP
cord-011435-x73foqu7	255	14	the	the	DET
cord-011435-x73foqu7	255	15	theme	theme	NOUN
cord-011435-x73foqu7	255	16	that	that	PRON
cord-011435-x73foqu7	255	17	ripa	ripa	NOUN
cord-011435-x73foqu7	255	18	-	-	PUNCT
cord-011435-x73foqu7	255	19	promoting	promote	VERB
cord-011435-x73foqu7	255	20	compounds	compound	NOUN
cord-011435-x73foqu7	255	21	are	be	AUX
cord-011435-x73foqu7	255	22	antiviral	antiviral	ADJ
cord-011435-x73foqu7	255	23	agents	agent	NOUN
cord-011435-x73foqu7	255	24	,	,	PUNCT
cord-011435-x73foqu7	255	25	we	we	PRON
cord-011435-x73foqu7	255	26	screened	screen	VERB
cord-011435-x73foqu7	255	27	a	a	DET
cord-011435-x73foqu7	255	28	subset	subset	NOUN
cord-011435-x73foqu7	255	29	of	of	ADP
cord-011435-x73foqu7	255	30	the	the	DET
cord-011435-x73foqu7	255	31	secondary	secondary	ADJ
cord-011435-x73foqu7	255	32	-	-	PUNCT
cord-011435-x73foqu7	255	33	validated	validate	VERB
cord-011435-x73foqu7	255	34	ripa	ripa	NOUN
cord-011435-x73foqu7	255	35	-	-	PUNCT
cord-011435-x73foqu7	255	36	promoters	promoter	NOUN
cord-011435-x73foqu7	255	37	(	(	PUNCT
cord-011435-x73foqu7	255	38	act12	act12	PROPN
cord-011435-x73foqu7	255	39	,	,	PUNCT
cord-011435-x73foqu7	255	40	act2	act2	PROPN
cord-011435-x73foqu7	255	41	,	,	PUNCT
cord-011435-x73foqu7	255	42	act5	act5	PROPN
cord-011435-x73foqu7	255	43	,	,	PUNCT
cord-011435-x73foqu7	255	44	act16	act16	NOUN
cord-011435-x73foqu7	255	45	,	,	PUNCT
cord-011435-x73foqu7	255	46	act9	act9	PROPN
cord-011435-x73foqu7	255	47	,	,	PUNCT
cord-011435-x73foqu7	255	48	and	and	CCONJ
cord-011435-x73foqu7	255	49	act3	act3	PROPN
cord-011435-x73foqu7	255	50	)	)	PUNCT
cord-011435-x73foqu7	255	51	,	,	PUNCT
cord-011435-x73foqu7	255	52	based	base	VERB
cord-011435-x73foqu7	255	53	on	on	ADP
cord-011435-x73foqu7	255	54	an	an	DET
cord-011435-x73foqu7	255	55	arbitrary	arbitrary	ADJ
cord-011435-x73foqu7	255	56	cut	cut	NOUN
cord-011435-x73foqu7	255	57	-	-	PUNCT
cord-011435-x73foqu7	255	58	off	off	NOUN
cord-011435-x73foqu7	255	59	of	of	ADP
cord-011435-x73foqu7	255	60	a	a	DET
cord-011435-x73foqu7	255	61	1.9	1.9	NUM
cord-011435-x73foqu7	255	62	-	-	ADJ
cord-011435-x73foqu7	255	63	fold	fold	ADJ
cord-011435-x73foqu7	255	64	increase	increase	NOUN
cord-011435-x73foqu7	255	65	in	in	ADP
cord-011435-x73foqu7	255	66	ripa	ripa	NOUN
cord-011435-x73foqu7	255	67	-	-	PUNCT
cord-011435-x73foqu7	255	68	promotion	promotion	NOUN
cord-011435-x73foqu7	255	69	(	(	PUNCT
cord-011435-x73foqu7	255	70	figure	figure	NOUN
cord-011435-x73foqu7	255	71	2c	2c	NOUN
cord-011435-x73foqu7	255	72	)	)	PUNCT
cord-011435-x73foqu7	255	73	,	,	PUNCT
cord-011435-x73foqu7	255	74	for	for	ADP
cord-011435-x73foqu7	255	75	their	their	PRON
cord-011435-x73foqu7	255	76	ability	ability	NOUN
cord-011435-x73foqu7	255	77	to	to	PART
cord-011435-x73foqu7	255	78	inhibit	inhibit	VERB
cord-011435-x73foqu7	255	79	hsv-1	hsv-1	PUNCT
cord-011435-x73foqu7	255	80	replication	replication	NOUN
cord-011435-x73foqu7	255	81	(	(	PUNCT
cord-011435-x73foqu7	255	82	figure	figure	NOUN
cord-011435-x73foqu7	255	83	8a	8a	NUM
cord-011435-x73foqu7	255	84	)	)	PUNCT
cord-011435-x73foqu7	255	85	.	.	PUNCT
cord-011435-x73foqu7	256	1	we	we	PRON
cord-011435-x73foqu7	256	2	confirmed	confirm	VERB
cord-011435-x73foqu7	256	3	the	the	DET
cord-011435-x73foqu7	256	4	anti	anti	ADJ
cord-011435-x73foqu7	256	5	-	-	ADJ
cord-011435-x73foqu7	256	6	hsv-1	hsv-1	ADJ
cord-011435-x73foqu7	256	7	activity	activity	NOUN
cord-011435-x73foqu7	256	8	of	of	ADP
cord-011435-x73foqu7	256	9	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	256	10	(	(	PUNCT
cord-011435-x73foqu7	256	11	act9	act9	PROPN
cord-011435-x73foqu7	256	12	)	)	PUNCT
cord-011435-x73foqu7	256	13	,	,	PUNCT
cord-011435-x73foqu7	256	14	and	and	CCONJ
cord-011435-x73foqu7	256	15	also	also	ADV
cord-011435-x73foqu7	256	16	isolated	isolate	VERB
cord-011435-x73foqu7	256	17	two	two	NUM
cord-011435-x73foqu7	256	18	additional	additional	ADJ
cord-011435-x73foqu7	256	19	compounds	compound	NOUN
cord-011435-x73foqu7	256	20	(	(	PUNCT
cord-011435-x73foqu7	256	21	act3	act3	NOUN
cord-011435-x73foqu7	256	22	and	and	CCONJ
cord-011435-x73foqu7	256	23	act5	act5	PROPN
cord-011435-x73foqu7	256	24	)	)	PUNCT
cord-011435-x73foqu7	256	25	that	that	PRON
cord-011435-x73foqu7	256	26	strongly	strongly	ADV
cord-011435-x73foqu7	256	27	inhibited	inhibit	VERB
cord-011435-x73foqu7	256	28	icp0	icp0	NOUN
cord-011435-x73foqu7	256	29	expression	expression	NOUN
cord-011435-x73foqu7	256	30	(	(	PUNCT
cord-011435-x73foqu7	256	31	figure	figure	NOUN
cord-011435-x73foqu7	256	32	8a	8a	NUM
cord-011435-x73foqu7	256	33	)	)	PUNCT
cord-011435-x73foqu7	256	34	.	.	PUNCT
cord-011435-x73foqu7	257	1	we	we	PRON
cord-011435-x73foqu7	257	2	excluded	exclude	VERB
cord-011435-x73foqu7	257	3	act3	act3	ADP
cord-011435-x73foqu7	257	4	(	(	PUNCT
cord-011435-x73foqu7	257	5	topotecan	topotecan	ADJ
cord-011435-x73foqu7	257	6	)	)	PUNCT
cord-011435-x73foqu7	257	7	from	from	ADP
cord-011435-x73foqu7	257	8	further	further	ADJ
cord-011435-x73foqu7	257	9	analyses	analysis	NOUN
cord-011435-x73foqu7	257	10	because	because	SCONJ
cord-011435-x73foqu7	257	11	it	it	PRON
cord-011435-x73foqu7	257	12	shares	share	VERB
cord-011435-x73foqu7	257	13	properties	property	NOUN
cord-011435-x73foqu7	257	14	with	with	ADP
cord-011435-x73foqu7	257	15	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	257	16	and	and	CCONJ
cord-011435-x73foqu7	257	17	may	may	AUX
cord-011435-x73foqu7	257	18	activate	activate	VERB
cord-011435-x73foqu7	257	19	similar	similar	ADJ
cord-011435-x73foqu7	257	20	pathways	pathway	NOUN
cord-011435-x73foqu7	257	21	.	.	PUNCT
cord-011435-x73foqu7	258	1	we	we	PRON
cord-011435-x73foqu7	258	2	focused	focus	VERB
cord-011435-x73foqu7	258	3	on	on	ADP
cord-011435-x73foqu7	258	4	the	the	DET
cord-011435-x73foqu7	258	5	anti	anti	ADJ
cord-011435-x73foqu7	258	6	-	-	ADJ
cord-011435-x73foqu7	258	7	helminthic	helminthic	ADJ
cord-011435-x73foqu7	258	8	drug	drug	NOUN
cord-011435-x73foqu7	258	9	pyrvinium	pyrvinium	ADP
cord-011435-x73foqu7	258	10	pamoate	pamoate	NOUN
cord-011435-x73foqu7	258	11	(	(	PUNCT
cord-011435-x73foqu7	258	12	pp	pp	ADV
cord-011435-x73foqu7	258	13	,	,	PUNCT
cord-011435-x73foqu7	258	14	act5	act5	PROPN
cord-011435-x73foqu7	258	15	)	)	PUNCT
cord-011435-x73foqu7	258	16	for	for	ADP
cord-011435-x73foqu7	258	17	validation	validation	NOUN
cord-011435-x73foqu7	258	18	of	of	ADP
cord-011435-x73foqu7	258	19	our	our	PRON
cord-011435-x73foqu7	258	20	hypothesis	hypothesis	NOUN
cord-011435-x73foqu7	258	21	.	.	PUNCT
cord-011435-x73foqu7	259	1	similar	similar	ADJ
cord-011435-x73foqu7	259	2	to	to	ADP
cord-011435-x73foqu7	259	3	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	259	4	,	,	PUNCT
cord-011435-x73foqu7	259	5	pp	pp	ADV
cord-011435-x73foqu7	259	6	inhibited	inhibit	VERB
cord-011435-x73foqu7	259	7	the	the	DET
cord-011435-x73foqu7	259	8	replication	replication	NOUN
cord-011435-x73foqu7	259	9	of	of	ADP
cord-011435-x73foqu7	259	10	hsv-1	hsv-1	PUNCT
cord-011435-x73foqu7	259	11	in	in	ADP
cord-011435-x73foqu7	259	12	ht1080	ht1080	PROPN
cord-011435-x73foqu7	259	13	cells	cell	NOUN
cord-011435-x73foqu7	259	14	,	,	PUNCT
cord-011435-x73foqu7	259	15	in	in	ADP
cord-011435-x73foqu7	259	16	a	a	DET
cord-011435-x73foqu7	259	17	dose	dose	NOUN
cord-011435-x73foqu7	259	18	-	-	PUNCT
cord-011435-x73foqu7	259	19	dependent	dependent	ADJ
cord-011435-x73foqu7	259	20	manner	manner	NOUN
cord-011435-x73foqu7	259	21	,	,	PUNCT
cord-011435-x73foqu7	259	22	demonstrated	demonstrate	VERB
cord-011435-x73foqu7	259	23	by	by	ADP
cord-011435-x73foqu7	259	24	immunoblot	immunoblot	NOUN
cord-011435-x73foqu7	259	25	of	of	ADP
cord-011435-x73foqu7	259	26	viral	viral	ADJ
cord-011435-x73foqu7	259	27	proteins	protein	NOUN
cord-011435-x73foqu7	259	28	icp0	icp0	NOUN
cord-011435-x73foqu7	259	29	and	and	CCONJ
cord-011435-x73foqu7	259	30	icp8	icp8	PROPN
cord-011435-x73foqu7	259	31	(	(	PUNCT
cord-011435-x73foqu7	259	32	figure	figure	VERB
cord-011435-x73foqu7	259	33	8b	8b	NUM
cord-011435-x73foqu7	259	34	)	)	PUNCT
cord-011435-x73foqu7	259	35	.	.	PUNCT
cord-011435-x73foqu7	260	1	pp	pp	ADV
cord-011435-x73foqu7	260	2	also	also	ADV
cord-011435-x73foqu7	260	3	inhibited	inhibit	VERB
cord-011435-x73foqu7	260	4	vsv	vsv	PROPN
cord-011435-x73foqu7	260	5	replication	replication	PROPN
cord-011435-x73foqu7	260	6	,	,	PUNCT
cord-011435-x73foqu7	260	7	analyzed	analyze	VERB
cord-011435-x73foqu7	260	8	by	by	ADP
cord-011435-x73foqu7	260	9	immunoblot	immunoblot	NOUN
cord-011435-x73foqu7	260	10	of	of	ADP
cord-011435-x73foqu7	260	11	the	the	DET
cord-011435-x73foqu7	260	12	viral	viral	ADJ
cord-011435-x73foqu7	260	13	protein	protein	NOUN
cord-011435-x73foqu7	260	14	vsv	vsv	PROPN
cord-011435-x73foqu7	260	15	-	-	PROPN
cord-011435-x73foqu7	260	16	g	g	NOUN
cord-011435-x73foqu7	260	17	(	(	PUNCT
cord-011435-x73foqu7	260	18	figure	figure	NOUN
cord-011435-x73foqu7	260	19	8c	8c	NUM
cord-011435-x73foqu7	260	20	)	)	PUNCT
cord-011435-x73foqu7	261	1	and	and	CCONJ
cord-011435-x73foqu7	261	2	infectious	infectious	ADJ
cord-011435-x73foqu7	261	3	virion	virion	NOUN
cord-011435-x73foqu7	261	4	particle	particle	NOUN
cord-011435-x73foqu7	261	5	release	release	NOUN
cord-011435-x73foqu7	261	6	(	(	PUNCT
cord-011435-x73foqu7	261	7	figure	figure	NOUN
cord-011435-x73foqu7	261	8	8d	8d	NOUN
cord-011435-x73foqu7	261	9	)	)	PUNCT
cord-011435-x73foqu7	261	10	.	.	PUNCT
cord-011435-x73foqu7	262	1	the	the	DET
cord-011435-x73foqu7	262	2	antiviral	antiviral	ADJ
cord-011435-x73foqu7	262	3	activity	activity	NOUN
cord-011435-x73foqu7	262	4	of	of	ADP
cord-011435-x73foqu7	262	5	pp	pp	PROPN
cord-011435-x73foqu7	262	6	prompted	prompt	VERB
cord-011435-x73foqu7	262	7	us	we	PRON
cord-011435-x73foqu7	262	8	to	to	PART
cord-011435-x73foqu7	262	9	test	test	VERB
cord-011435-x73foqu7	262	10	its	its	PRON
cord-011435-x73foqu7	262	11	ability	ability	NOUN
cord-011435-x73foqu7	262	12	to	to	PART
cord-011435-x73foqu7	262	13	activate	activate	VERB
cord-011435-x73foqu7	262	14	irf3	irf3	PROPN
cord-011435-x73foqu7	262	15	.	.	PUNCT
cord-011435-x73foqu7	263	1	pp	pp	ADV
cord-011435-x73foqu7	263	2	,	,	PUNCT
cord-011435-x73foqu7	263	3	as	as	SCONJ
cord-011435-x73foqu7	263	4	expected	expect	VERB
cord-011435-x73foqu7	263	5	,	,	PUNCT
cord-011435-x73foqu7	263	6	promoted	promote	VERB
cord-011435-x73foqu7	263	7	the	the	DET
cord-011435-x73foqu7	263	8	ripa	ripa	ADJ
cord-011435-x73foqu7	263	9	branch	branch	NOUN
cord-011435-x73foqu7	263	10	of	of	ADP
cord-011435-x73foqu7	263	11	irf3	irf3	PROPN
cord-011435-x73foqu7	263	12	,	,	PUNCT
cord-011435-x73foqu7	263	13	measured	measure	VERB
cord-011435-x73foqu7	263	14	by	by	ADP
cord-011435-x73foqu7	263	15	caspase	caspase	NOUN
cord-011435-x73foqu7	263	16	activity	activity	NOUN
cord-011435-x73foqu7	263	17	(	(	PUNCT
cord-011435-x73foqu7	263	18	figure	figure	NOUN
cord-011435-x73foqu7	263	19	8e	8e	NUM
cord-011435-x73foqu7	263	20	)	)	PUNCT
cord-011435-x73foqu7	263	21	and	and	CCONJ
cord-011435-x73foqu7	263	22	c	c	X
cord-011435-x73foqu7	263	23	-	-	NOUN
cord-011435-x73foqu7	263	24	parp	parp	NOUN
cord-011435-x73foqu7	263	25	(	(	PUNCT
cord-011435-x73foqu7	263	26	figure	figure	NOUN
cord-011435-x73foqu7	263	27	8f	8f	NOUN
cord-011435-x73foqu7	263	28	)	)	PUNCT
cord-011435-x73foqu7	263	29	.	.	PUNCT
cord-011435-x73foqu7	264	1	unlike	unlike	ADP
cord-011435-x73foqu7	264	2	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	264	3	,	,	PUNCT
cord-011435-x73foqu7	264	4	pp	pp	ADJ
cord-011435-x73foqu7	264	5	treatment	treatment	NOUN
cord-011435-x73foqu7	264	6	did	do	AUX
cord-011435-x73foqu7	264	7	not	not	PART
cord-011435-x73foqu7	264	8	trigger	trigger	VERB
cord-011435-x73foqu7	264	9	an	an	DET
cord-011435-x73foqu7	264	10	apoptotic	apoptotic	ADJ
cord-011435-x73foqu7	264	11	pathway	pathway	NOUN
cord-011435-x73foqu7	264	12	in	in	ADP
cord-011435-x73foqu7	264	13	the	the	DET
cord-011435-x73foqu7	264	14	absence	absence	NOUN
cord-011435-x73foqu7	264	15	of	of	ADP
cord-011435-x73foqu7	264	16	rlr	rlr	NOUN
cord-011435-x73foqu7	264	17	-	-	PUNCT
cord-011435-x73foqu7	264	18	stimulation	stimulation	NOUN
cord-011435-x73foqu7	264	19	(	(	PUNCT
cord-011435-x73foqu7	264	20	figure	figure	NOUN
cord-011435-x73foqu7	264	21	8f	8f	NOUN
cord-011435-x73foqu7	264	22	,	,	PUNCT
cord-011435-x73foqu7	264	23	lane	lane	NOUN
cord-011435-x73foqu7	264	24	2	2	NUM
cord-011435-x73foqu7	264	25	)	)	PUNCT
cord-011435-x73foqu7	264	26	.	.	PUNCT
cord-011435-x73foqu7	265	1	to	to	PART
cord-011435-x73foqu7	265	2	investigate	investigate	VERB
cord-011435-x73foqu7	265	3	whether	whether	SCONJ
cord-011435-x73foqu7	265	4	pp	pp	PROPN
cord-011435-x73foqu7	265	5	uses	use	VERB
cord-011435-x73foqu7	265	6	a	a	DET
cord-011435-x73foqu7	265	7	mechanism	mechanism	NOUN
cord-011435-x73foqu7	265	8	similar	similar	ADJ
cord-011435-x73foqu7	265	9	to	to	ADP
cord-011435-x73foqu7	265	10	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	265	11	to	to	PART
cord-011435-x73foqu7	265	12	promote	promote	VERB
cord-011435-x73foqu7	265	13	ripa	ripa	ADJ
cord-011435-x73foqu7	265	14	,	,	PUNCT
cord-011435-x73foqu7	265	15	we	we	PRON
cord-011435-x73foqu7	265	16	tested	test	VERB
cord-011435-x73foqu7	265	17	the	the	DET
cord-011435-x73foqu7	265	18	mek	mek	PROPN
cord-011435-x73foqu7	265	19	inhibitor	inhibitor	NOUN
cord-011435-x73foqu7	265	20	in	in	ADP
cord-011435-x73foqu7	265	21	pp	pp	ADV
cord-011435-x73foqu7	265	22	-	-	PUNCT
cord-011435-x73foqu7	265	23	promoted	promote	VERB
cord-011435-x73foqu7	265	24	ripa	ripa	NOUN
cord-011435-x73foqu7	265	25	.	.	PUNCT
cord-011435-x73foqu7	266	1	inhibition	inhibition	NOUN
cord-011435-x73foqu7	266	2	of	of	ADP
cord-011435-x73foqu7	266	3	mek	mek	PROPN
cord-011435-x73foqu7	266	4	reduced	reduce	VERB
cord-011435-x73foqu7	266	5	rlr	rlr	NOUN
cord-011435-x73foqu7	266	6	-	-	PUNCT
cord-011435-x73foqu7	266	7	induced	induce	VERB
cord-011435-x73foqu7	266	8	c	c	NOUN
cord-011435-x73foqu7	266	9	-	-	NOUN
cord-011435-x73foqu7	266	10	parp	parp	NOUN
cord-011435-x73foqu7	266	11	in	in	ADP
cord-011435-x73foqu7	266	12	pp	pp	ADV
cord-011435-x73foqu7	266	13	-	-	PUNCT
cord-011435-x73foqu7	266	14	treated	treat	VERB
cord-011435-x73foqu7	266	15	cells	cell	NOUN
cord-011435-x73foqu7	266	16	(	(	PUNCT
cord-011435-x73foqu7	266	17	figure	figure	VERB
cord-011435-x73foqu7	266	18	8	8	NUM
cord-011435-x73foqu7	266	19	g	g	NOUN
cord-011435-x73foqu7	266	20	)	)	PUNCT
cord-011435-x73foqu7	266	21	.	.	PUNCT
cord-011435-x73foqu7	267	1	therefore	therefore	ADV
cord-011435-x73foqu7	267	2	,	,	PUNCT
cord-011435-x73foqu7	267	3	erk	erk	PROPN
cord-011435-x73foqu7	267	4	signaling	signaling	NOUN
cord-011435-x73foqu7	267	5	may	may	AUX
cord-011435-x73foqu7	267	6	be	be	AUX
cord-011435-x73foqu7	267	7	a	a	DET
cord-011435-x73foqu7	267	8	common	common	ADJ
cord-011435-x73foqu7	267	9	mechanism	mechanism	NOUN
cord-011435-x73foqu7	267	10	to	to	PART
cord-011435-x73foqu7	267	11	therapeutically	therapeutically	ADV
cord-011435-x73foqu7	267	12	target	target	VERB
cord-011435-x73foqu7	267	13	ripa	ripa	NOUN
cord-011435-x73foqu7	267	14	in	in	ADP
cord-011435-x73foqu7	267	15	multiple	multiple	ADJ
cord-011435-x73foqu7	267	16	cell	cell	NOUN
cord-011435-x73foqu7	267	17	types	type	NOUN
cord-011435-x73foqu7	267	18	.	.	PUNCT
cord-011435-x73foqu7	268	1	next	next	ADV
cord-011435-x73foqu7	268	2	,	,	PUNCT
cord-011435-x73foqu7	268	3	we	we	PRON
cord-011435-x73foqu7	268	4	inquired	inquire	VERB
cord-011435-x73foqu7	268	5	about	about	ADP
cord-011435-x73foqu7	268	6	the	the	DET
cord-011435-x73foqu7	268	7	effect	effect	NOUN
cord-011435-x73foqu7	268	8	of	of	ADP
cord-011435-x73foqu7	268	9	pp	pp	PROPN
cord-011435-x73foqu7	268	10	on	on	ADP
cord-011435-x73foqu7	268	11	the	the	DET
cord-011435-x73foqu7	268	12	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	268	13	activity	activity	NOUN
cord-011435-x73foqu7	268	14	of	of	ADP
cord-011435-x73foqu7	268	15	irf3	irf3	PROPN
cord-011435-x73foqu7	268	16	.	.	PUNCT
cord-011435-x73foqu7	269	1	interestingly	interestingly	ADV
cord-011435-x73foqu7	269	2	,	,	PUNCT
cord-011435-x73foqu7	269	3	although	although	SCONJ
cord-011435-x73foqu7	269	4	pp	pp	PROPN
cord-011435-x73foqu7	269	5	promoted	promote	VERB
cord-011435-x73foqu7	269	6	the	the	DET
cord-011435-x73foqu7	269	7	ripa	ripa	ADJ
cord-011435-x73foqu7	269	8	branch	branch	NOUN
cord-011435-x73foqu7	269	9	of	of	ADP
cord-011435-x73foqu7	269	10	irf3	irf3	PROPN
cord-011435-x73foqu7	269	11	(	(	PUNCT
cord-011435-x73foqu7	269	12	figure	figure	NOUN
cord-011435-x73foqu7	269	13	8e	8e	NUM
cord-011435-x73foqu7	269	14	,	,	PUNCT
cord-011435-x73foqu7	269	15	f	f	PROPN
cord-011435-x73foqu7	269	16	)	)	PUNCT
cord-011435-x73foqu7	269	17	,	,	PUNCT
cord-011435-x73foqu7	269	18	it	it	PRON
cord-011435-x73foqu7	269	19	had	have	VERB
cord-011435-x73foqu7	269	20	no	no	DET
cord-011435-x73foqu7	269	21	effect	effect	NOUN
cord-011435-x73foqu7	269	22	on	on	ADP
cord-011435-x73foqu7	269	23	the	the	DET
cord-011435-x73foqu7	269	24	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	269	25	activity	activity	NOUN
cord-011435-x73foqu7	269	26	of	of	ADP
cord-011435-x73foqu7	269	27	irf3	irf3	PROPN
cord-011435-x73foqu7	269	28	,	,	PUNCT
cord-011435-x73foqu7	269	29	demonstrated	demonstrate	VERB
cord-011435-x73foqu7	269	30	by	by	ADP
cord-011435-x73foqu7	269	31	qrt	qrt	ADJ
cord-011435-x73foqu7	269	32	-	-	PUNCT
cord-011435-x73foqu7	269	33	pcr	pcr	NOUN
cord-011435-x73foqu7	269	34	analyses	analysis	NOUN
cord-011435-x73foqu7	269	35	of	of	ADP
cord-011435-x73foqu7	269	36	irf3	irf3	PROPN
cord-011435-x73foqu7	269	37	target	target	NOUN
cord-011435-x73foqu7	269	38	genes	gene	NOUN
cord-011435-x73foqu7	269	39	(	(	PUNCT
cord-011435-x73foqu7	269	40	figure	figure	NOUN
cord-011435-x73foqu7	269	41	8h	8h	NUM
cord-011435-x73foqu7	269	42	,	,	PUNCT
cord-011435-x73foqu7	269	43	i	i	NOUN
cord-011435-x73foqu7	269	44	)	)	PUNCT
cord-011435-x73foqu7	269	45	.	.	PUNCT
cord-011435-x73foqu7	270	1	therefore	therefore	ADV
cord-011435-x73foqu7	270	2	,	,	PUNCT
cord-011435-x73foqu7	270	3	in	in	ADP
cord-011435-x73foqu7	270	4	contrast	contrast	NOUN
cord-011435-x73foqu7	270	5	to	to	ADP
cord-011435-x73foqu7	270	6	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	270	7	,	,	PUNCT
cord-011435-x73foqu7	270	8	which	which	PRON
cord-011435-x73foqu7	270	9	differentially	differentially	ADV
cord-011435-x73foqu7	270	10	modulates	modulate	VERB
cord-011435-x73foqu7	270	11	irf3	irf3	PROPN
cord-011435-x73foqu7	270	12	activity	activity	NOUN
cord-011435-x73foqu7	270	13	by	by	ADP
cord-011435-x73foqu7	270	14	promoting	promote	VERB
cord-011435-x73foqu7	270	15	ripa	ripa	NOUN
cord-011435-x73foqu7	270	16	and	and	CCONJ
cord-011435-x73foqu7	270	17	inhibiting	inhibit	VERB
cord-011435-x73foqu7	270	18	the	the	DET
cord-011435-x73foqu7	270	19	irf3	irf3	PROPN
cord-011435-x73foqu7	270	20	transcriptional	transcriptional	NOUN
cord-011435-x73foqu7	270	21	branch	branch	NOUN
cord-011435-x73foqu7	270	22	,	,	PUNCT
cord-011435-x73foqu7	270	23	pp	pp	ADV
cord-011435-x73foqu7	270	24	exclusively	exclusively	ADV
cord-011435-x73foqu7	270	25	promotes	promote	VERB
cord-011435-x73foqu7	270	26	ripa	ripa	NOUN
cord-011435-x73foqu7	270	27	without	without	ADP
cord-011435-x73foqu7	270	28	affecting	affect	VERB
cord-011435-x73foqu7	270	29	irf3	irf3	NOUN
cord-011435-x73foqu7	270	30	transcriptional	transcriptional	NOUN
cord-011435-x73foqu7	270	31	activity	activity	NOUN
cord-011435-x73foqu7	270	32	.	.	PUNCT
cord-011435-x73foqu7	271	1	mechanism	mechanism	NOUN
cord-011435-x73foqu7	271	2	to	to	PART
cord-011435-x73foqu7	271	3	therapeutically	therapeutically	ADV
cord-011435-x73foqu7	271	4	target	target	VERB
cord-011435-x73foqu7	271	5	ripa	ripa	NOUN
cord-011435-x73foqu7	271	6	in	in	ADP
cord-011435-x73foqu7	271	7	multiple	multiple	ADJ
cord-011435-x73foqu7	271	8	cell	cell	NOUN
cord-011435-x73foqu7	271	9	types	type	NOUN
cord-011435-x73foqu7	271	10	.	.	PUNCT
cord-011435-x73foqu7	272	1	next	next	ADV
cord-011435-x73foqu7	272	2	,	,	PUNCT
cord-011435-x73foqu7	272	3	we	we	PRON
cord-011435-x73foqu7	272	4	inquired	inquire	VERB
cord-011435-x73foqu7	272	5	about	about	ADP
cord-011435-x73foqu7	272	6	the	the	DET
cord-011435-x73foqu7	272	7	effect	effect	NOUN
cord-011435-x73foqu7	272	8	of	of	ADP
cord-011435-x73foqu7	272	9	pp	pp	PROPN
cord-011435-x73foqu7	272	10	on	on	ADP
cord-011435-x73foqu7	272	11	the	the	DET
cord-011435-x73foqu7	272	12	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	272	13	activity	activity	NOUN
cord-011435-x73foqu7	272	14	of	of	ADP
cord-011435-x73foqu7	272	15	irf3	irf3	PROPN
cord-011435-x73foqu7	272	16	.	.	PUNCT
cord-011435-x73foqu7	273	1	interestingly	interestingly	ADV
cord-011435-x73foqu7	273	2	,	,	PUNCT
cord-011435-x73foqu7	273	3	although	although	SCONJ
cord-011435-x73foqu7	273	4	pp	pp	PROPN
cord-011435-x73foqu7	273	5	promoted	promote	VERB
cord-011435-x73foqu7	273	6	the	the	DET
cord-011435-x73foqu7	273	7	ripa	ripa	ADJ
cord-011435-x73foqu7	273	8	branch	branch	NOUN
cord-011435-x73foqu7	273	9	of	of	ADP
cord-011435-x73foqu7	273	10	irf3	irf3	PROPN
cord-011435-x73foqu7	273	11	(	(	PUNCT
cord-011435-x73foqu7	273	12	figure	figure	NOUN
cord-011435-x73foqu7	273	13	8e	8e	NUM
cord-011435-x73foqu7	273	14	,	,	PUNCT
cord-011435-x73foqu7	273	15	f	f	PROPN
cord-011435-x73foqu7	273	16	)	)	PUNCT
cord-011435-x73foqu7	273	17	,	,	PUNCT
cord-011435-x73foqu7	273	18	it	it	PRON
cord-011435-x73foqu7	273	19	had	have	VERB
cord-011435-x73foqu7	273	20	no	no	DET
cord-011435-x73foqu7	273	21	effect	effect	NOUN
cord-011435-x73foqu7	273	22	on	on	ADP
cord-011435-x73foqu7	273	23	the	the	DET
cord-011435-x73foqu7	273	24	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	273	25	activity	activity	NOUN
cord-011435-x73foqu7	273	26	of	of	ADP
cord-011435-x73foqu7	273	27	irf3	irf3	PROPN
cord-011435-x73foqu7	273	28	,	,	PUNCT
cord-011435-x73foqu7	273	29	demonstrated	demonstrate	VERB
cord-011435-x73foqu7	273	30	by	by	ADP
cord-011435-x73foqu7	273	31	qrt	qrt	ADJ
cord-011435-x73foqu7	273	32	-	-	PUNCT
cord-011435-x73foqu7	273	33	pcr	pcr	NOUN
cord-011435-x73foqu7	273	34	analyses	analysis	NOUN
cord-011435-x73foqu7	273	35	of	of	ADP
cord-011435-x73foqu7	273	36	irf3	irf3	PROPN
cord-011435-x73foqu7	273	37	target	target	NOUN
cord-011435-x73foqu7	273	38	genes	gene	NOUN
cord-011435-x73foqu7	273	39	(	(	PUNCT
cord-011435-x73foqu7	273	40	figure	figure	NOUN
cord-011435-x73foqu7	273	41	8h	8h	NUM
cord-011435-x73foqu7	273	42	,	,	PUNCT
cord-011435-x73foqu7	273	43	i	i	NOUN
cord-011435-x73foqu7	273	44	)	)	PUNCT
cord-011435-x73foqu7	273	45	.	.	PUNCT
cord-011435-x73foqu7	274	1	therefore	therefore	ADV
cord-011435-x73foqu7	274	2	,	,	PUNCT
cord-011435-x73foqu7	274	3	in	in	ADP
cord-011435-x73foqu7	274	4	contrast	contrast	NOUN
cord-011435-x73foqu7	274	5	to	to	ADP
cord-011435-x73foqu7	274	6	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	274	7	,	,	PUNCT
cord-011435-x73foqu7	274	8	which	which	PRON
cord-011435-x73foqu7	274	9	differentially	differentially	ADV
cord-011435-x73foqu7	274	10	modulates	modulate	VERB
cord-011435-x73foqu7	274	11	irf3	irf3	PROPN
cord-011435-x73foqu7	274	12	activity	activity	NOUN
cord-011435-x73foqu7	274	13	by	by	ADP
cord-011435-x73foqu7	274	14	promoting	promote	VERB
cord-011435-x73foqu7	274	15	ripa	ripa	NOUN
cord-011435-x73foqu7	274	16	and	and	CCONJ
cord-011435-x73foqu7	274	17	inhibiting	inhibit	VERB
cord-011435-x73foqu7	274	18	the	the	DET
cord-011435-x73foqu7	274	19	irf3	irf3	PROPN
cord-011435-x73foqu7	274	20	transcriptional	transcriptional	NOUN
cord-011435-x73foqu7	274	21	branch	branch	NOUN
cord-011435-x73foqu7	274	22	,	,	PUNCT
cord-011435-x73foqu7	274	23	pp	pp	ADV
cord-011435-x73foqu7	274	24	exclusively	exclusively	ADV
cord-011435-x73foqu7	274	25	promotes	promote	VERB
cord-011435-x73foqu7	274	26	ripa	ripa	NOUN
cord-011435-x73foqu7	274	27	without	without	ADP
cord-011435-x73foqu7	274	28	affecting	affect	VERB
cord-011435-x73foqu7	274	29	irf3	irf3	NOUN
cord-011435-x73foqu7	274	30	transcriptional	transcriptional	NOUN
cord-011435-x73foqu7	274	31	activity	activity	NOUN
cord-011435-x73foqu7	274	32	.	.	PUNCT
cord-011435-x73foqu7	275	1	we	we	PRON
cord-011435-x73foqu7	275	2	have	have	AUX
cord-011435-x73foqu7	275	3	previously	previously	ADV
cord-011435-x73foqu7	275	4	demonstrated	demonstrate	VERB
cord-011435-x73foqu7	275	5	,	,	PUNCT
cord-011435-x73foqu7	275	6	using	use	VERB
cord-011435-x73foqu7	275	7	genetically	genetically	ADV
cord-011435-x73foqu7	275	8	manipulated	manipulate	VERB
cord-011435-x73foqu7	275	9	cells	cell	NOUN
cord-011435-x73foqu7	275	10	and	and	CCONJ
cord-011435-x73foqu7	275	11	mice	mouse	NOUN
cord-011435-x73foqu7	275	12	,	,	PUNCT
cord-011435-x73foqu7	275	13	that	that	SCONJ
cord-011435-x73foqu7	275	14	nt	nt	PROPN
cord-011435-x73foqu7	275	15	-	-	PUNCT
cord-011435-x73foqu7	275	16	irf3	irf3	PROPN
cord-011435-x73foqu7	275	17	function	function	NOUN
cord-011435-x73foqu7	275	18	via	via	ADP
cord-011435-x73foqu7	275	19	ripa	ripa	NOUN
cord-011435-x73foqu7	275	20	contributes	contribute	VERB
cord-011435-x73foqu7	275	21	to	to	ADP
cord-011435-x73foqu7	275	22	the	the	DET
cord-011435-x73foqu7	275	23	optimal	optimal	ADJ
cord-011435-x73foqu7	275	24	antiviral	antiviral	ADJ
cord-011435-x73foqu7	275	25	activity	activity	NOUN
cord-011435-x73foqu7	275	26	of	of	ADP
cord-011435-x73foqu7	275	27	irf3	irf3	PROPN
cord-011435-x73foqu7	275	28	[	[	PUNCT
cord-011435-x73foqu7	275	29	7	7	NUM
cord-011435-x73foqu7	275	30	]	]	PUNCT
cord-011435-x73foqu7	275	31	[	[	X
cord-011435-x73foqu7	275	32	8	8	NUM
cord-011435-x73foqu7	275	33	]	]	PUNCT
cord-011435-x73foqu7	275	34	[	[	X
cord-011435-x73foqu7	275	35	9	9	NUM
cord-011435-x73foqu7	275	36	]	]	PUNCT
cord-011435-x73foqu7	275	37	[	[	X
cord-011435-x73foqu7	275	38	10	10	NUM
cord-011435-x73foqu7	275	39	]	]	PUNCT
cord-011435-x73foqu7	275	40	12	12	NUM
cord-011435-x73foqu7	275	41	]	]	PUNCT
cord-011435-x73foqu7	275	42	.	.	PUNCT
cord-011435-x73foqu7	276	1	in	in	ADP
cord-011435-x73foqu7	276	2	the	the	DET
cord-011435-x73foqu7	276	3	current	current	ADJ
cord-011435-x73foqu7	276	4	study	study	NOUN
cord-011435-x73foqu7	276	5	,	,	PUNCT
cord-011435-x73foqu7	276	6	we	we	PRON
cord-011435-x73foqu7	276	7	sought	seek	VERB
cord-011435-x73foqu7	276	8	to	to	PART
cord-011435-x73foqu7	276	9	identify	identify	VERB
cord-011435-x73foqu7	276	10	small	small	ADJ
cord-011435-x73foqu7	276	11	molecules	molecule	NOUN
cord-011435-x73foqu7	276	12	that	that	PRON
cord-011435-x73foqu7	276	13	activate	activate	VERB
cord-011435-x73foqu7	276	14	ripa	ripa	NOUN
cord-011435-x73foqu7	276	15	and	and	CCONJ
cord-011435-x73foqu7	276	16	,	,	PUNCT
cord-011435-x73foqu7	276	17	therefore	therefore	ADV
cord-011435-x73foqu7	276	18	,	,	PUNCT
cord-011435-x73foqu7	276	19	can	can	AUX
cord-011435-x73foqu7	276	20	limit	limit	VERB
cord-011435-x73foqu7	276	21	virus	virus	NOUN
cord-011435-x73foqu7	276	22	replication	replication	NOUN
cord-011435-x73foqu7	276	23	.	.	PUNCT
cord-011435-x73foqu7	277	1	using	use	VERB
cord-011435-x73foqu7	277	2	a	a	DET
cord-011435-x73foqu7	277	3	high	high	ADJ
cord-011435-x73foqu7	277	4	-	-	PUNCT
cord-011435-x73foqu7	277	5	throughput	throughput	NOUN
cord-011435-x73foqu7	277	6	screen	screen	NOUN
cord-011435-x73foqu7	277	7	of	of	ADP
cord-011435-x73foqu7	277	8	a	a	DET
cord-011435-x73foqu7	277	9	library	library	NOUN
cord-011435-x73foqu7	277	10	of	of	ADP
cord-011435-x73foqu7	277	11	fda	fda	PROPN
cord-011435-x73foqu7	277	12	-	-	PUNCT
cord-011435-x73foqu7	277	13	approved	approve	VERB
cord-011435-x73foqu7	277	14	drugs	drug	NOUN
cord-011435-x73foqu7	277	15	,	,	PUNCT
cord-011435-x73foqu7	277	16	we	we	PRON
cord-011435-x73foqu7	277	17	isolated	isolate	VERB
cord-011435-x73foqu7	277	18	a	a	DET
cord-011435-x73foqu7	277	19	subset	subset	NOUN
cord-011435-x73foqu7	277	20	of	of	ADP
cord-011435-x73foqu7	277	21	compounds	compound	NOUN
cord-011435-x73foqu7	277	22	with	with	ADP
cord-011435-x73foqu7	277	23	diverse	diverse	ADJ
cord-011435-x73foqu7	277	24	therapeutic	therapeutic	ADJ
cord-011435-x73foqu7	277	25	functions	function	NOUN
cord-011435-x73foqu7	277	26	that	that	PRON
cord-011435-x73foqu7	277	27	promoted	promote	VERB
cord-011435-x73foqu7	277	28	the	the	DET
cord-011435-x73foqu7	277	29	activity	activity	NOUN
cord-011435-x73foqu7	277	30	of	of	ADP
cord-011435-x73foqu7	277	31	ripa	ripa	PROPN
cord-011435-x73foqu7	277	32	.	.	PUNCT
cord-011435-x73foqu7	278	1	among	among	ADP
cord-011435-x73foqu7	278	2	the	the	DET
cord-011435-x73foqu7	278	3	ripaactivating	ripaactivating	NOUN
cord-011435-x73foqu7	278	4	compounds	compound	NOUN
cord-011435-x73foqu7	278	5	,	,	PUNCT
cord-011435-x73foqu7	278	6	we	we	PRON
cord-011435-x73foqu7	278	7	focused	focus	VERB
cord-011435-x73foqu7	278	8	on	on	ADP
cord-011435-x73foqu7	278	9	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	278	10	for	for	ADP
cord-011435-x73foqu7	278	11	mechanistic	mechanistic	ADJ
cord-011435-x73foqu7	278	12	and	and	CCONJ
cord-011435-x73foqu7	278	13	functional	functional	ADJ
cord-011435-x73foqu7	278	14	studies	study	NOUN
cord-011435-x73foqu7	278	15	.	.	PUNCT
cord-011435-x73foqu7	279	1	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	279	2	inhibits	inhibit	VERB
cord-011435-x73foqu7	279	3	the	the	DET
cord-011435-x73foqu7	279	4	replication	replication	NOUN
cord-011435-x73foqu7	279	5	of	of	ADP
cord-011435-x73foqu7	279	6	vsv	vsv	PROPN
cord-011435-x73foqu7	279	7	by	by	ADP
cord-011435-x73foqu7	279	8	activating	activate	VERB
cord-011435-x73foqu7	279	9	the	the	DET
cord-011435-x73foqu7	279	10	ripa	ripa	ADJ
cord-011435-x73foqu7	279	11	branch	branch	NOUN
cord-011435-x73foqu7	279	12	of	of	ADP
cord-011435-x73foqu7	279	13	irf3	irf3	PROPN
cord-011435-x73foqu7	279	14	.	.	PUNCT
cord-011435-x73foqu7	280	1	our	our	PRON
cord-011435-x73foqu7	280	2	in	in	ADP
cord-011435-x73foqu7	280	3	-	-	PUNCT
cord-011435-x73foqu7	280	4	depth	depth	NOUN
cord-011435-x73foqu7	280	5	biochemical	biochemical	ADJ
cord-011435-x73foqu7	280	6	studies	study	NOUN
cord-011435-x73foqu7	280	7	revealed	reveal	VERB
cord-011435-x73foqu7	280	8	that	that	SCONJ
cord-011435-x73foqu7	280	9	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	280	10	inhibited	inhibit	VERB
cord-011435-x73foqu7	280	11	the	the	DET
cord-011435-x73foqu7	280	12	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	280	13	activity	activity	NOUN
cord-011435-x73foqu7	280	14	of	of	ADP
cord-011435-x73foqu7	280	15	irf3	irf3	PROPN
cord-011435-x73foqu7	280	16	;	;	PUNCT
cord-011435-x73foqu7	280	17	moreover	moreover	ADV
cord-011435-x73foqu7	280	18	,	,	PUNCT
cord-011435-x73foqu7	280	19	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	280	20	promoted	promote	VERB
cord-011435-x73foqu7	280	21	ripa	ripa	NOUN
cord-011435-x73foqu7	280	22	by	by	ADP
cord-011435-x73foqu7	280	23	activating	activate	VERB
cord-011435-x73foqu7	280	24	the	the	DET
cord-011435-x73foqu7	280	25	erk	erk	NOUN
cord-011435-x73foqu7	280	26	signaling	signal	VERB
cord-011435-x73foqu7	280	27	pathway	pathway	NOUN
cord-011435-x73foqu7	280	28	.	.	PUNCT
cord-011435-x73foqu7	281	1	the	the	DET
cord-011435-x73foqu7	281	2	antiviral	antiviral	ADJ
cord-011435-x73foqu7	281	3	function	function	NOUN
cord-011435-x73foqu7	281	4	of	of	ADP
cord-011435-x73foqu7	281	5	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	281	6	was	be	AUX
cord-011435-x73foqu7	281	7	expanded	expand	VERB
cord-011435-x73foqu7	281	8	to	to	ADP
cord-011435-x73foqu7	281	9	the	the	DET
cord-011435-x73foqu7	281	10	tick	tick	NOUN
cord-011435-x73foqu7	281	11	-	-	PUNCT
cord-011435-x73foqu7	281	12	and	and	CCONJ
cord-011435-x73foqu7	281	13	mosquito	mosquito	PROPN
cord-011435-x73foqu7	281	14	-	-	PUNCT
cord-011435-x73foqu7	281	15	borne	bear	VERB
cord-011435-x73foqu7	281	16	flaviviruses	flavivirus	NOUN
cord-011435-x73foqu7	281	17	(	(	PUNCT
cord-011435-x73foqu7	281	18	lgtv	lgtv	PROPN
cord-011435-x73foqu7	281	19	and	and	CCONJ
cord-011435-x73foqu7	281	20	kunv	kunv	PROPN
cord-011435-x73foqu7	281	21	)	)	PUNCT
cord-011435-x73foqu7	281	22	,	,	PUNCT
cord-011435-x73foqu7	281	23	and	and	CCONJ
cord-011435-x73foqu7	281	24	hsv-1	hsv-1	NOUN
cord-011435-x73foqu7	281	25	.	.	PUNCT
cord-011435-x73foqu7	282	1	finally	finally	ADV
cord-011435-x73foqu7	282	2	,	,	PUNCT
cord-011435-x73foqu7	282	3	we	we	PRON
cord-011435-x73foqu7	282	4	validated	validate	VERB
cord-011435-x73foqu7	282	5	our	our	PRON
cord-011435-x73foqu7	282	6	results	result	NOUN
cord-011435-x73foqu7	282	7	using	use	VERB
cord-011435-x73foqu7	282	8	pyrvinium	pyrvinium	PROPN
cord-011435-x73foqu7	282	9	pamoate	pamoate	NOUN
cord-011435-x73foqu7	282	10	,	,	PUNCT
cord-011435-x73foqu7	282	11	which	which	PRON
cord-011435-x73foqu7	282	12	also	also	ADV
cord-011435-x73foqu7	282	13	inhibited	inhibit	VERB
cord-011435-x73foqu7	282	14	the	the	DET
cord-011435-x73foqu7	282	15	replication	replication	NOUN
cord-011435-x73foqu7	282	16	of	of	ADP
cord-011435-x73foqu7	282	17	vsv	vsv	PROPN
cord-011435-x73foqu7	282	18	and	and	CCONJ
cord-011435-x73foqu7	282	19	hsv-1	hsv-1	PUNCT
cord-011435-x73foqu7	282	20	by	by	ADP
cord-011435-x73foqu7	282	21	specifically	specifically	ADV
cord-011435-x73foqu7	282	22	promoting	promote	VERB
cord-011435-x73foqu7	282	23	ripa	ripa	NOUN
cord-011435-x73foqu7	282	24	,	,	PUNCT
cord-011435-x73foqu7	282	25	and	and	CCONJ
cord-011435-x73foqu7	282	26	not	not	PART
cord-011435-x73foqu7	282	27	the	the	DET
cord-011435-x73foqu7	282	28	transcriptional	transcriptional	NOUN
cord-011435-x73foqu7	282	29	,	,	PUNCT
cord-011435-x73foqu7	282	30	we	we	PRON
cord-011435-x73foqu7	282	31	have	have	AUX
cord-011435-x73foqu7	282	32	previously	previously	ADV
cord-011435-x73foqu7	282	33	demonstrated	demonstrate	VERB
cord-011435-x73foqu7	282	34	,	,	PUNCT
cord-011435-x73foqu7	282	35	using	use	VERB
cord-011435-x73foqu7	282	36	genetically	genetically	ADV
cord-011435-x73foqu7	282	37	manipulated	manipulate	VERB
cord-011435-x73foqu7	282	38	cells	cell	NOUN
cord-011435-x73foqu7	282	39	and	and	CCONJ
cord-011435-x73foqu7	282	40	mice	mouse	NOUN
cord-011435-x73foqu7	282	41	,	,	PUNCT
cord-011435-x73foqu7	282	42	that	that	SCONJ
cord-011435-x73foqu7	282	43	nt	nt	PROPN
cord-011435-x73foqu7	282	44	-	-	PUNCT
cord-011435-x73foqu7	282	45	irf3	irf3	PROPN
cord-011435-x73foqu7	282	46	function	function	NOUN
cord-011435-x73foqu7	282	47	via	via	ADP
cord-011435-x73foqu7	282	48	ripa	ripa	NOUN
cord-011435-x73foqu7	282	49	contributes	contribute	VERB
cord-011435-x73foqu7	282	50	to	to	ADP
cord-011435-x73foqu7	282	51	the	the	DET
cord-011435-x73foqu7	282	52	optimal	optimal	ADJ
cord-011435-x73foqu7	282	53	antiviral	antiviral	ADJ
cord-011435-x73foqu7	282	54	activity	activity	NOUN
cord-011435-x73foqu7	282	55	of	of	ADP
cord-011435-x73foqu7	282	56	irf3	irf3	PROPN
cord-011435-x73foqu7	282	57	[	[	PUNCT
cord-011435-x73foqu7	282	58	7	7	NUM
cord-011435-x73foqu7	282	59	]	]	PUNCT
cord-011435-x73foqu7	282	60	[	[	X
cord-011435-x73foqu7	282	61	8	8	NUM
cord-011435-x73foqu7	282	62	]	]	PUNCT
cord-011435-x73foqu7	282	63	[	[	X
cord-011435-x73foqu7	282	64	9	9	NUM
cord-011435-x73foqu7	282	65	]	]	PUNCT
cord-011435-x73foqu7	282	66	[	[	X
cord-011435-x73foqu7	282	67	10	10	NUM
cord-011435-x73foqu7	282	68	]	]	PUNCT
cord-011435-x73foqu7	282	69	12	12	NUM
cord-011435-x73foqu7	282	70	]	]	PUNCT
cord-011435-x73foqu7	282	71	.	.	PUNCT
cord-011435-x73foqu7	283	1	in	in	ADP
cord-011435-x73foqu7	283	2	the	the	DET
cord-011435-x73foqu7	283	3	current	current	ADJ
cord-011435-x73foqu7	283	4	study	study	NOUN
cord-011435-x73foqu7	283	5	,	,	PUNCT
cord-011435-x73foqu7	283	6	we	we	PRON
cord-011435-x73foqu7	283	7	sought	seek	VERB
cord-011435-x73foqu7	283	8	to	to	PART
cord-011435-x73foqu7	283	9	identify	identify	VERB
cord-011435-x73foqu7	283	10	small	small	ADJ
cord-011435-x73foqu7	283	11	molecules	molecule	NOUN
cord-011435-x73foqu7	283	12	that	that	PRON
cord-011435-x73foqu7	283	13	activate	activate	VERB
cord-011435-x73foqu7	283	14	ripa	ripa	NOUN
cord-011435-x73foqu7	283	15	and	and	CCONJ
cord-011435-x73foqu7	283	16	,	,	PUNCT
cord-011435-x73foqu7	283	17	therefore	therefore	ADV
cord-011435-x73foqu7	283	18	,	,	PUNCT
cord-011435-x73foqu7	283	19	can	can	AUX
cord-011435-x73foqu7	283	20	limit	limit	VERB
cord-011435-x73foqu7	283	21	virus	virus	NOUN
cord-011435-x73foqu7	283	22	replication	replication	NOUN
cord-011435-x73foqu7	283	23	.	.	PUNCT
cord-011435-x73foqu7	284	1	using	use	VERB
cord-011435-x73foqu7	284	2	a	a	DET
cord-011435-x73foqu7	284	3	high	high	ADJ
cord-011435-x73foqu7	284	4	-	-	PUNCT
cord-011435-x73foqu7	284	5	throughput	throughput	NOUN
cord-011435-x73foqu7	284	6	screen	screen	NOUN
cord-011435-x73foqu7	284	7	of	of	ADP
cord-011435-x73foqu7	284	8	a	a	DET
cord-011435-x73foqu7	284	9	library	library	NOUN
cord-011435-x73foqu7	284	10	of	of	ADP
cord-011435-x73foqu7	284	11	fda	fda	PROPN
cord-011435-x73foqu7	284	12	-	-	PUNCT
cord-011435-x73foqu7	284	13	approved	approve	VERB
cord-011435-x73foqu7	284	14	drugs	drug	NOUN
cord-011435-x73foqu7	284	15	,	,	PUNCT
cord-011435-x73foqu7	284	16	we	we	PRON
cord-011435-x73foqu7	284	17	isolated	isolate	VERB
cord-011435-x73foqu7	284	18	a	a	DET
cord-011435-x73foqu7	284	19	subset	subset	NOUN
cord-011435-x73foqu7	284	20	of	of	ADP
cord-011435-x73foqu7	284	21	compounds	compound	NOUN
cord-011435-x73foqu7	284	22	with	with	ADP
cord-011435-x73foqu7	284	23	diverse	diverse	ADJ
cord-011435-x73foqu7	284	24	therapeutic	therapeutic	ADJ
cord-011435-x73foqu7	284	25	functions	function	NOUN
cord-011435-x73foqu7	284	26	that	that	PRON
cord-011435-x73foqu7	284	27	promoted	promote	VERB
cord-011435-x73foqu7	284	28	the	the	DET
cord-011435-x73foqu7	284	29	activity	activity	NOUN
cord-011435-x73foqu7	284	30	of	of	ADP
cord-011435-x73foqu7	284	31	ripa	ripa	PROPN
cord-011435-x73foqu7	284	32	.	.	PUNCT
cord-011435-x73foqu7	285	1	among	among	ADP
cord-011435-x73foqu7	285	2	the	the	DET
cord-011435-x73foqu7	285	3	ripa	ripa	NOUN
cord-011435-x73foqu7	285	4	-	-	PUNCT
cord-011435-x73foqu7	285	5	activating	activate	VERB
cord-011435-x73foqu7	285	6	compounds	compound	NOUN
cord-011435-x73foqu7	285	7	,	,	PUNCT
cord-011435-x73foqu7	285	8	we	we	PRON
cord-011435-x73foqu7	285	9	focused	focus	VERB
cord-011435-x73foqu7	285	10	on	on	ADP
cord-011435-x73foqu7	285	11	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	285	12	for	for	ADP
cord-011435-x73foqu7	285	13	mechanistic	mechanistic	ADJ
cord-011435-x73foqu7	285	14	and	and	CCONJ
cord-011435-x73foqu7	285	15	functional	functional	ADJ
cord-011435-x73foqu7	285	16	studies	study	NOUN
cord-011435-x73foqu7	285	17	.	.	PUNCT
cord-011435-x73foqu7	286	1	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	286	2	inhibits	inhibit	VERB
cord-011435-x73foqu7	286	3	the	the	DET
cord-011435-x73foqu7	286	4	replication	replication	NOUN
cord-011435-x73foqu7	286	5	of	of	ADP
cord-011435-x73foqu7	286	6	vsv	vsv	PROPN
cord-011435-x73foqu7	286	7	by	by	ADP
cord-011435-x73foqu7	286	8	activating	activate	VERB
cord-011435-x73foqu7	286	9	the	the	DET
cord-011435-x73foqu7	286	10	ripa	ripa	ADJ
cord-011435-x73foqu7	286	11	branch	branch	NOUN
cord-011435-x73foqu7	286	12	of	of	ADP
cord-011435-x73foqu7	286	13	irf3	irf3	PROPN
cord-011435-x73foqu7	286	14	.	.	PUNCT
cord-011435-x73foqu7	287	1	our	our	PRON
cord-011435-x73foqu7	287	2	in	in	ADP
cord-011435-x73foqu7	287	3	-	-	PUNCT
cord-011435-x73foqu7	287	4	depth	depth	NOUN
cord-011435-x73foqu7	287	5	biochemical	biochemical	ADJ
cord-011435-x73foqu7	287	6	studies	study	NOUN
cord-011435-x73foqu7	287	7	revealed	reveal	VERB
cord-011435-x73foqu7	287	8	that	that	SCONJ
cord-011435-x73foqu7	287	9	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	287	10	inhibited	inhibit	VERB
cord-011435-x73foqu7	287	11	the	the	DET
cord-011435-x73foqu7	287	12	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	287	13	activity	activity	NOUN
cord-011435-x73foqu7	287	14	of	of	ADP
cord-011435-x73foqu7	287	15	irf3	irf3	PROPN
cord-011435-x73foqu7	287	16	;	;	PUNCT
cord-011435-x73foqu7	287	17	moreover	moreover	ADV
cord-011435-x73foqu7	287	18	,	,	PUNCT
cord-011435-x73foqu7	287	19	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	287	20	promoted	promote	VERB
cord-011435-x73foqu7	287	21	ripa	ripa	NOUN
cord-011435-x73foqu7	287	22	by	by	ADP
cord-011435-x73foqu7	287	23	activating	activate	VERB
cord-011435-x73foqu7	287	24	the	the	DET
cord-011435-x73foqu7	287	25	erk	erk	NOUN
cord-011435-x73foqu7	287	26	signaling	signal	VERB
cord-011435-x73foqu7	287	27	pathway	pathway	NOUN
cord-011435-x73foqu7	287	28	.	.	PUNCT
cord-011435-x73foqu7	288	1	the	the	DET
cord-011435-x73foqu7	288	2	antiviral	antiviral	ADJ
cord-011435-x73foqu7	288	3	function	function	NOUN
cord-011435-x73foqu7	288	4	of	of	ADP
cord-011435-x73foqu7	288	5	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	288	6	was	be	AUX
cord-011435-x73foqu7	288	7	expanded	expand	VERB
cord-011435-x73foqu7	288	8	to	to	ADP
cord-011435-x73foqu7	288	9	the	the	DET
cord-011435-x73foqu7	288	10	tick	tick	NOUN
cord-011435-x73foqu7	288	11	-	-	PUNCT
cord-011435-x73foqu7	288	12	and	and	CCONJ
cord-011435-x73foqu7	288	13	mosquito	mosquito	PROPN
cord-011435-x73foqu7	288	14	-	-	PUNCT
cord-011435-x73foqu7	288	15	borne	bear	VERB
cord-011435-x73foqu7	288	16	flaviviruses	flavivirus	NOUN
cord-011435-x73foqu7	288	17	(	(	PUNCT
cord-011435-x73foqu7	288	18	lgtv	lgtv	PROPN
cord-011435-x73foqu7	288	19	and	and	CCONJ
cord-011435-x73foqu7	288	20	kunv	kunv	PROPN
cord-011435-x73foqu7	288	21	)	)	PUNCT
cord-011435-x73foqu7	288	22	,	,	PUNCT
cord-011435-x73foqu7	288	23	and	and	CCONJ
cord-011435-x73foqu7	288	24	hsv-1	hsv-1	NOUN
cord-011435-x73foqu7	288	25	.	.	PUNCT
cord-011435-x73foqu7	289	1	finally	finally	ADV
cord-011435-x73foqu7	289	2	,	,	PUNCT
cord-011435-x73foqu7	289	3	we	we	PRON
cord-011435-x73foqu7	289	4	validated	validate	VERB
cord-011435-x73foqu7	289	5	our	our	PRON
cord-011435-x73foqu7	289	6	results	result	NOUN
cord-011435-x73foqu7	289	7	using	use	VERB
cord-011435-x73foqu7	289	8	pyrvinium	pyrvinium	PROPN
cord-011435-x73foqu7	289	9	pamoate	pamoate	NOUN
cord-011435-x73foqu7	289	10	,	,	PUNCT
cord-011435-x73foqu7	289	11	which	which	PRON
cord-011435-x73foqu7	289	12	also	also	ADV
cord-011435-x73foqu7	289	13	inhibited	inhibit	VERB
cord-011435-x73foqu7	289	14	the	the	DET
cord-011435-x73foqu7	289	15	replication	replication	NOUN
cord-011435-x73foqu7	289	16	of	of	ADP
cord-011435-x73foqu7	289	17	vsv	vsv	PROPN
cord-011435-x73foqu7	289	18	and	and	CCONJ
cord-011435-x73foqu7	289	19	hsv-1	hsv-1	PUNCT
cord-011435-x73foqu7	289	20	by	by	ADP
cord-011435-x73foqu7	289	21	specifically	specifically	ADV
cord-011435-x73foqu7	289	22	promoting	promote	VERB
cord-011435-x73foqu7	289	23	ripa	ripa	NOUN
cord-011435-x73foqu7	289	24	,	,	PUNCT
cord-011435-x73foqu7	289	25	and	and	CCONJ
cord-011435-x73foqu7	289	26	not	not	PART
cord-011435-x73foqu7	289	27	the	the	DET
cord-011435-x73foqu7	289	28	transcriptional	transcriptional	NOUN
cord-011435-x73foqu7	289	29	,	,	PUNCT
cord-011435-x73foqu7	289	30	function	function	NOUN
cord-011435-x73foqu7	289	31	of	of	ADP
cord-011435-x73foqu7	289	32	irf3	irf3	PROPN
cord-011435-x73foqu7	289	33	.	.	PUNCT
cord-011435-x73foqu7	290	1	therefore	therefore	ADV
cord-011435-x73foqu7	290	2	,	,	PUNCT
cord-011435-x73foqu7	290	3	we	we	PRON
cord-011435-x73foqu7	290	4	demonstrate	demonstrate	VERB
cord-011435-x73foqu7	290	5	that	that	SCONJ
cord-011435-x73foqu7	290	6	compounds	compound	NOUN
cord-011435-x73foqu7	290	7	that	that	PRON
cord-011435-x73foqu7	290	8	activate	activate	VERB
cord-011435-x73foqu7	290	9	ripa	ripa	NOUN
cord-011435-x73foqu7	290	10	have	have	VERB
cord-011435-x73foqu7	290	11	potential	potential	NOUN
cord-011435-x73foqu7	290	12	for	for	ADP
cord-011435-x73foqu7	290	13	antiviral	antiviral	ADJ
cord-011435-x73foqu7	290	14	action	action	NOUN
cord-011435-x73foqu7	290	15	.	.	PUNCT
cord-011435-x73foqu7	291	1	high	high	ADJ
cord-011435-x73foqu7	291	2	throughput	throughput	NOUN
cord-011435-x73foqu7	291	3	screening	screen	VERB
cord-011435-x73foqu7	291	4	to	to	PART
cord-011435-x73foqu7	291	5	isolate	isolate	VERB
cord-011435-x73foqu7	291	6	novel	novel	ADJ
cord-011435-x73foqu7	291	7	antiviral	antiviral	ADJ
cord-011435-x73foqu7	291	8	compounds	compound	NOUN
cord-011435-x73foqu7	291	9	is	be	AUX
cord-011435-x73foqu7	291	10	a	a	DET
cord-011435-x73foqu7	291	11	widely	widely	ADV
cord-011435-x73foqu7	291	12	accepted	accept	VERB
cord-011435-x73foqu7	291	13	strategy	strategy	NOUN
cord-011435-x73foqu7	291	14	,	,	PUNCT
cord-011435-x73foqu7	291	15	and	and	CCONJ
cord-011435-x73foqu7	291	16	commonly	commonly	ADV
cord-011435-x73foqu7	291	17	utilizes	utilize	VERB
cord-011435-x73foqu7	291	18	virus	virus	NOUN
cord-011435-x73foqu7	291	19	replication	replication	NOUN
cord-011435-x73foqu7	291	20	as	as	ADP
cord-011435-x73foqu7	291	21	a	a	DET
cord-011435-x73foqu7	291	22	terminal	terminal	ADJ
cord-011435-x73foqu7	291	23	readout	readout	NOUN
cord-011435-x73foqu7	291	24	.	.	PUNCT
cord-011435-x73foqu7	292	1	we	we	PRON
cord-011435-x73foqu7	292	2	took	take	VERB
cord-011435-x73foqu7	292	3	a	a	DET
cord-011435-x73foqu7	292	4	novel	novel	ADJ
cord-011435-x73foqu7	292	5	approach	approach	NOUN
cord-011435-x73foqu7	292	6	to	to	PART
cord-011435-x73foqu7	292	7	isolate	isolate	VERB
cord-011435-x73foqu7	292	8	the	the	DET
cord-011435-x73foqu7	292	9	antiviral	antiviral	ADJ
cord-011435-x73foqu7	292	10	agents	agent	NOUN
cord-011435-x73foqu7	292	11	by	by	ADP
cord-011435-x73foqu7	292	12	screening	screen	VERB
cord-011435-x73foqu7	292	13	for	for	ADP
cord-011435-x73foqu7	292	14	activators	activator	NOUN
cord-011435-x73foqu7	292	15	of	of	ADP
cord-011435-x73foqu7	292	16	a	a	DET
cord-011435-x73foqu7	292	17	cellular	cellular	ADJ
cord-011435-x73foqu7	292	18	antiviral	antiviral	ADJ
cord-011435-x73foqu7	292	19	pathway	pathway	NOUN
cord-011435-x73foqu7	292	20	.	.	PUNCT
cord-011435-x73foqu7	293	1	irf3	irf3	PROPN
cord-011435-x73foqu7	293	2	is	be	AUX
cord-011435-x73foqu7	293	3	the	the	DET
cord-011435-x73foqu7	293	4	key	key	ADJ
cord-011435-x73foqu7	293	5	transcription	transcription	NOUN
cord-011435-x73foqu7	293	6	factor	factor	NOUN
cord-011435-x73foqu7	293	7	for	for	ADP
cord-011435-x73foqu7	293	8	the	the	DET
cord-011435-x73foqu7	293	9	induction	induction	NOUN
cord-011435-x73foqu7	293	10	of	of	ADP
cord-011435-x73foqu7	293	11	ifn	ifn	ADJ
cord-011435-x73foqu7	293	12	and	and	CCONJ
cord-011435-x73foqu7	293	13	antiviral	antiviral	ADJ
cord-011435-x73foqu7	293	14	isgs	isgs	PROPN
cord-011435-x73foqu7	293	15	[	[	PUNCT
cord-011435-x73foqu7	293	16	1	1	NUM
cord-011435-x73foqu7	293	17	,	,	PUNCT
cord-011435-x73foqu7	293	18	4	4	NUM
cord-011435-x73foqu7	293	19	,	,	PUNCT
cord-011435-x73foqu7	293	20	37	37	NUM
cord-011435-x73foqu7	293	21	,	,	PUNCT
cord-011435-x73foqu7	293	22	38	38	NUM
cord-011435-x73foqu7	293	23	]	]	PUNCT
cord-011435-x73foqu7	293	24	.	.	PUNCT
cord-011435-x73foqu7	294	1	we	we	PRON
cord-011435-x73foqu7	294	2	have	have	AUX
cord-011435-x73foqu7	294	3	uncovered	uncover	VERB
cord-011435-x73foqu7	294	4	a	a	DET
cord-011435-x73foqu7	294	5	pro	pro	ADJ
cord-011435-x73foqu7	294	6	-	-	ADJ
cord-011435-x73foqu7	294	7	apoptotic	apoptotic	ADJ
cord-011435-x73foqu7	294	8	pathway	pathway	NOUN
cord-011435-x73foqu7	294	9	of	of	ADP
cord-011435-x73foqu7	294	10	nt	nt	PROPN
cord-011435-x73foqu7	294	11	-	-	PUNCT
cord-011435-x73foqu7	294	12	irf3	irf3	PROPN
cord-011435-x73foqu7	294	13	,	,	PUNCT
cord-011435-x73foqu7	294	14	ripa	ripa	PROPN
cord-011435-x73foqu7	294	15	,	,	PUNCT
cord-011435-x73foqu7	294	16	in	in	ADP
cord-011435-x73foqu7	294	17	virus	virus	NOUN
cord-011435-x73foqu7	294	18	-	-	PUNCT
cord-011435-x73foqu7	294	19	infected	infect	VERB
cord-011435-x73foqu7	294	20	cells	cell	NOUN
cord-011435-x73foqu7	294	21	[	[	PUNCT
cord-011435-x73foqu7	294	22	7	7	NUM
cord-011435-x73foqu7	294	23	,	,	PUNCT
cord-011435-x73foqu7	294	24	9	9	NUM
cord-011435-x73foqu7	294	25	,	,	PUNCT
cord-011435-x73foqu7	294	26	13	13	NUM
cord-011435-x73foqu7	294	27	]	]	PUNCT
cord-011435-x73foqu7	294	28	.	.	PUNCT
cord-011435-x73foqu7	295	1	using	use	VERB
cord-011435-x73foqu7	295	2	cells	cell	NOUN
cord-011435-x73foqu7	295	3	and	and	CCONJ
cord-011435-x73foqu7	295	4	mice	mouse	NOUN
cord-011435-x73foqu7	295	5	expressing	express	VERB
cord-011435-x73foqu7	295	6	a	a	DET
cord-011435-x73foqu7	295	7	ripa	ripa	NOUN
cord-011435-x73foqu7	295	8	active	active	ADJ
cord-011435-x73foqu7	295	9	nt	not	PART
cord-011435-x73foqu7	295	10	-	-	PUNCT
cord-011435-x73foqu7	295	11	irf3	irf3	PROPN
cord-011435-x73foqu7	295	12	mutant	mutant	NOUN
cord-011435-x73foqu7	295	13	,	,	PUNCT
cord-011435-x73foqu7	295	14	we	we	PRON
cord-011435-x73foqu7	295	15	demonstrated	demonstrate	VERB
cord-011435-x73foqu7	295	16	the	the	DET
cord-011435-x73foqu7	295	17	relative	relative	ADJ
cord-011435-x73foqu7	295	18	contribution	contribution	NOUN
cord-011435-x73foqu7	295	19	of	of	ADP
cord-011435-x73foqu7	295	20	ripa	ripa	NOUN
cord-011435-x73foqu7	295	21	to	to	ADP
cord-011435-x73foqu7	295	22	the	the	DET
cord-011435-x73foqu7	295	23	antiviral	antiviral	ADJ
cord-011435-x73foqu7	295	24	response	response	NOUN
cord-011435-x73foqu7	295	25	of	of	ADP
cord-011435-x73foqu7	295	26	irf3	irf3	PROPN
cord-011435-x73foqu7	295	27	[	[	PUNCT
cord-011435-x73foqu7	295	28	7	7	NUM
cord-011435-x73foqu7	295	29	]	]	PUNCT
cord-011435-x73foqu7	295	30	.	.	PUNCT
cord-011435-x73foqu7	296	1	several	several	ADJ
cord-011435-x73foqu7	296	2	high	high	ADJ
cord-011435-x73foqu7	296	3	throughput	throughput	NOUN
cord-011435-x73foqu7	296	4	screens	screen	NOUN
cord-011435-x73foqu7	296	5	have	have	AUX
cord-011435-x73foqu7	296	6	revealed	reveal	VERB
cord-011435-x73foqu7	296	7	small	small	ADJ
cord-011435-x73foqu7	296	8	molecules	molecule	NOUN
cord-011435-x73foqu7	296	9	that	that	PRON
cord-011435-x73foqu7	296	10	regulate	regulate	VERB
cord-011435-x73foqu7	296	11	the	the	DET
cord-011435-x73foqu7	296	12	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	296	13	activity	activity	NOUN
cord-011435-x73foqu7	296	14	of	of	ADP
cord-011435-x73foqu7	296	15	irf3	irf3	PROPN
cord-011435-x73foqu7	296	16	[	[	PUNCT
cord-011435-x73foqu7	296	17	39	39	NUM
cord-011435-x73foqu7	296	18	]	]	PUNCT
cord-011435-x73foqu7	296	19	[	[	X
cord-011435-x73foqu7	296	20	40	40	NUM
cord-011435-x73foqu7	296	21	]	]	PUNCT
cord-011435-x73foqu7	296	22	[	[	X
cord-011435-x73foqu7	296	23	41	41	NUM
cord-011435-x73foqu7	296	24	]	]	PUNCT
cord-011435-x73foqu7	296	25	[	[	X
cord-011435-x73foqu7	296	26	42	42	NUM
cord-011435-x73foqu7	296	27	]	]	PUNCT
cord-011435-x73foqu7	297	1	[	[	X
cord-011435-x73foqu7	297	2	43	43	NUM
cord-011435-x73foqu7	297	3	]	]	PUNCT
cord-011435-x73foqu7	297	4	.	.	PUNCT
cord-011435-x73foqu7	298	1	however	however	ADV
cord-011435-x73foqu7	298	2	,	,	PUNCT
cord-011435-x73foqu7	298	3	because	because	SCONJ
cord-011435-x73foqu7	298	4	ripa	ripa	PROPN
cord-011435-x73foqu7	298	5	is	be	AUX
cord-011435-x73foqu7	298	6	newly	newly	ADV
cord-011435-x73foqu7	298	7	identified	identify	VERB
cord-011435-x73foqu7	298	8	,	,	PUNCT
cord-011435-x73foqu7	298	9	there	there	PRON
cord-011435-x73foqu7	298	10	are	be	VERB
cord-011435-x73foqu7	298	11	no	no	DET
cord-011435-x73foqu7	298	12	known	know	VERB
cord-011435-x73foqu7	298	13	regulators	regulator	NOUN
cord-011435-x73foqu7	298	14	of	of	ADP
cord-011435-x73foqu7	298	15	this	this	DET
cord-011435-x73foqu7	298	16	pathway	pathway	NOUN
cord-011435-x73foqu7	298	17	.	.	PUNCT
cord-011435-x73foqu7	299	1	this	this	PRON
cord-011435-x73foqu7	299	2	led	lead	VERB
cord-011435-x73foqu7	299	3	us	we	PRON
cord-011435-x73foqu7	299	4	to	to	PART
cord-011435-x73foqu7	299	5	develop	develop	VERB
cord-011435-x73foqu7	299	6	an	an	DET
cord-011435-x73foqu7	299	7	unbiased	unbiased	ADJ
cord-011435-x73foqu7	299	8	screen	screen	NOUN
cord-011435-x73foqu7	299	9	,	,	PUNCT
cord-011435-x73foqu7	299	10	using	use	VERB
cord-011435-x73foqu7	299	11	a	a	DET
cord-011435-x73foqu7	299	12	library	library	NOUN
cord-011435-x73foqu7	299	13	of	of	ADP
cord-011435-x73foqu7	299	14	fda	fda	PROPN
cord-011435-x73foqu7	299	15	-	-	PUNCT
cord-011435-x73foqu7	299	16	approved	approve	VERB
cord-011435-x73foqu7	299	17	drugs	drug	NOUN
cord-011435-x73foqu7	299	18	,	,	PUNCT
cord-011435-x73foqu7	299	19	to	to	PART
cord-011435-x73foqu7	299	20	isolate	isolate	VERB
cord-011435-x73foqu7	299	21	ripa	ripa	PROPN
cord-011435-x73foqu7	299	22	-	-	PUNCT
cord-011435-x73foqu7	299	23	activators	activator	NOUN
cord-011435-x73foqu7	299	24	that	that	PRON
cord-011435-x73foqu7	299	25	would	would	AUX
cord-011435-x73foqu7	299	26	function	function	VERB
cord-011435-x73foqu7	299	27	as	as	ADP
cord-011435-x73foqu7	299	28	antiviral	antiviral	ADJ
cord-011435-x73foqu7	299	29	agents	agent	NOUN
cord-011435-x73foqu7	299	30	.	.	PUNCT
cord-011435-x73foqu7	300	1	using	use	VERB
cord-011435-x73foqu7	300	2	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	300	3	,	,	PUNCT
cord-011435-x73foqu7	300	4	a	a	DET
cord-011435-x73foqu7	300	5	new	new	ADJ
cord-011435-x73foqu7	300	6	ripa	ripa	NOUN
cord-011435-x73foqu7	300	7	activator	activator	NOUN
cord-011435-x73foqu7	300	8	,	,	PUNCT
cord-011435-x73foqu7	300	9	we	we	PRON
cord-011435-x73foqu7	300	10	examined	examine	VERB
cord-011435-x73foqu7	300	11	both	both	DET
cord-011435-x73foqu7	300	12	activities	activity	NOUN
cord-011435-x73foqu7	300	13	of	of	ADP
cord-011435-x73foqu7	300	14	irf3	irf3	PROPN
cord-011435-x73foqu7	300	15	,	,	PUNCT
cord-011435-x73foqu7	300	16	because	because	SCONJ
cord-011435-x73foqu7	300	17	an	an	DET
cord-011435-x73foqu7	300	18	activator	activator	NOUN
cord-011435-x73foqu7	300	19	of	of	ADP
cord-011435-x73foqu7	300	20	either	either	DET
cord-011435-x73foqu7	300	21	pathway	pathway	NOUN
cord-011435-x73foqu7	300	22	would	would	AUX
cord-011435-x73foqu7	300	23	provide	provide	VERB
cord-011435-x73foqu7	300	24	an	an	DET
cord-011435-x73foqu7	300	25	antiviral	antiviral	ADJ
cord-011435-x73foqu7	300	26	response	response	NOUN
cord-011435-x73foqu7	300	27	.	.	PUNCT
cord-011435-x73foqu7	301	1	although	although	SCONJ
cord-011435-x73foqu7	301	2	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	301	3	promoted	promote	VERB
cord-011435-x73foqu7	301	4	ripa	ripa	NOUN
cord-011435-x73foqu7	301	5	in	in	ADP
cord-011435-x73foqu7	301	6	multiple	multiple	ADJ
cord-011435-x73foqu7	301	7	cell	cell	NOUN
cord-011435-x73foqu7	301	8	types	type	NOUN
cord-011435-x73foqu7	301	9	,	,	PUNCT
cord-011435-x73foqu7	301	10	it	it	PRON
cord-011435-x73foqu7	301	11	inhibited	inhibit	VERB
cord-011435-x73foqu7	301	12	the	the	DET
cord-011435-x73foqu7	301	13	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	301	14	activity	activity	NOUN
cord-011435-x73foqu7	301	15	of	of	ADP
cord-011435-x73foqu7	301	16	irf3	irf3	PROPN
cord-011435-x73foqu7	301	17	.	.	PUNCT
cord-011435-x73foqu7	302	1	therefore	therefore	ADV
cord-011435-x73foqu7	302	2	,	,	PUNCT
cord-011435-x73foqu7	302	3	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	302	4	inhibits	inhibit	VERB
cord-011435-x73foqu7	302	5	virus	virus	NOUN
cord-011435-x73foqu7	302	6	replication	replication	NOUN
cord-011435-x73foqu7	302	7	in	in	ADP
cord-011435-x73foqu7	302	8	the	the	DET
cord-011435-x73foqu7	302	9	absence	absence	NOUN
cord-011435-x73foqu7	302	10	of	of	ADP
cord-011435-x73foqu7	302	11	irf3	irf3	PROPN
cord-011435-x73foqu7	302	12	-	-	PUNCT
cord-011435-x73foqu7	302	13	induced	induce	VERB
cord-011435-x73foqu7	302	14	antiviral	antiviral	ADJ
cord-011435-x73foqu7	302	15	genes	gene	NOUN
cord-011435-x73foqu7	302	16	,	,	PUNCT
cord-011435-x73foqu7	302	17	further	far	ADV
cord-011435-x73foqu7	302	18	emphasizing	emphasize	VERB
cord-011435-x73foqu7	302	19	the	the	DET
cord-011435-x73foqu7	302	20	biological	biological	ADJ
cord-011435-x73foqu7	302	21	significance	significance	NOUN
cord-011435-x73foqu7	302	22	of	of	ADP
cord-011435-x73foqu7	302	23	ripa	ripa	PROPN
cord-011435-x73foqu7	302	24	.	.	PUNCT
cord-011435-x73foqu7	303	1	how	how	SCONJ
cord-011435-x73foqu7	303	2	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	303	3	inhibits	inhibit	VERB
cord-011435-x73foqu7	303	4	the	the	DET
cord-011435-x73foqu7	303	5	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	303	6	activity	activity	NOUN
cord-011435-x73foqu7	303	7	of	of	ADP
cord-011435-x73foqu7	303	8	irf3	irf3	PROPN
cord-011435-x73foqu7	303	9	is	be	AUX
cord-011435-x73foqu7	303	10	a	a	DET
cord-011435-x73foqu7	303	11	topic	topic	NOUN
cord-011435-x73foqu7	303	12	of	of	ADP
cord-011435-x73foqu7	303	13	future	future	ADJ
cord-011435-x73foqu7	303	14	investigation	investigation	NOUN
cord-011435-x73foqu7	303	15	.	.	PUNCT
cord-011435-x73foqu7	304	1	the	the	DET
cord-011435-x73foqu7	304	2	dna	dna	PROPN
cord-011435-x73foqu7	304	3	-	-	PUNCT
cord-011435-x73foqu7	304	4	damaging	damage	VERB
cord-011435-x73foqu7	304	5	property	property	NOUN
cord-011435-x73foqu7	304	6	of	of	ADP
cord-011435-x73foqu7	304	7	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	304	8	[	[	PUNCT
cord-011435-x73foqu7	304	9	44	44	NUM
cord-011435-x73foqu7	304	10	]	]	PUNCT
cord-011435-x73foqu7	304	11	may	may	AUX
cord-011435-x73foqu7	304	12	contribute	contribute	VERB
cord-011435-x73foqu7	304	13	to	to	ADP
cord-011435-x73foqu7	304	14	this	this	DET
cord-011435-x73foqu7	304	15	activity	activity	NOUN
cord-011435-x73foqu7	304	16	.	.	PUNCT
cord-011435-x73foqu7	305	1	furthermore	furthermore	ADV
cord-011435-x73foqu7	305	2	,	,	PUNCT
cord-011435-x73foqu7	305	3	whether	whether	SCONJ
cord-011435-x73foqu7	305	4	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	305	5	,	,	PUNCT
cord-011435-x73foqu7	305	6	in	in	ADP
cord-011435-x73foqu7	305	7	addition	addition	NOUN
cord-011435-x73foqu7	305	8	to	to	ADP
cord-011435-x73foqu7	305	9	ripa	ripa	ADJ
cord-011435-x73foqu7	305	10	promotion	promotion	NOUN
cord-011435-x73foqu7	305	11	,	,	PUNCT
cord-011435-x73foqu7	305	12	can	can	AUX
cord-011435-x73foqu7	305	13	intercalate	intercalate	VERB
cord-011435-x73foqu7	305	14	with	with	ADP
cord-011435-x73foqu7	305	15	viral	viral	ADJ
cord-011435-x73foqu7	305	16	genomic	genomic	ADJ
cord-011435-x73foqu7	305	17	dna	dna	NOUN
cord-011435-x73foqu7	305	18	to	to	PART
cord-011435-x73foqu7	305	19	inhibit	inhibit	VERB
cord-011435-x73foqu7	305	20	viral	viral	ADJ
cord-011435-x73foqu7	305	21	replication	replication	NOUN
cord-011435-x73foqu7	305	22	,	,	PUNCT
cord-011435-x73foqu7	305	23	will	will	AUX
cord-011435-x73foqu7	305	24	require	require	VERB
cord-011435-x73foqu7	305	25	further	further	ADJ
cord-011435-x73foqu7	305	26	studies	study	NOUN
cord-011435-x73foqu7	305	27	.	.	PUNCT
cord-011435-x73foqu7	306	1	our	our	PRON
cord-011435-x73foqu7	306	2	screen	screen	NOUN
cord-011435-x73foqu7	306	3	isolated	isolate	VERB
cord-011435-x73foqu7	306	4	,	,	PUNCT
cord-011435-x73foqu7	306	5	in	in	ADP
cord-011435-x73foqu7	306	6	addition	addition	NOUN
cord-011435-x73foqu7	306	7	to	to	ADP
cord-011435-x73foqu7	306	8	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	306	9	,	,	PUNCT
cord-011435-x73foqu7	306	10	pyrvinium	pyrvinium	PROPN
cord-011435-x73foqu7	306	11	pamoate	pamoate	NOUN
cord-011435-x73foqu7	306	12	,	,	PUNCT
cord-011435-x73foqu7	306	13	which	which	PRON
cord-011435-x73foqu7	306	14	specifically	specifically	ADV
cord-011435-x73foqu7	306	15	promoted	promote	VERB
cord-011435-x73foqu7	306	16	ripa	ripa	NOUN
cord-011435-x73foqu7	306	17	,	,	PUNCT
cord-011435-x73foqu7	306	18	but	but	CCONJ
cord-011435-x73foqu7	306	19	not	not	PART
cord-011435-x73foqu7	306	20	the	the	DET
cord-011435-x73foqu7	306	21	transcriptional	transcriptional	NOUN
cord-011435-x73foqu7	306	22	function	function	NOUN
cord-011435-x73foqu7	306	23	,	,	PUNCT
cord-011435-x73foqu7	306	24	of	of	ADP
cord-011435-x73foqu7	306	25	irf3	irf3	PROPN
cord-011435-x73foqu7	306	26	.	.	PUNCT
cord-011435-x73foqu7	307	1	many	many	ADJ
cord-011435-x73foqu7	307	2	viruses	virus	NOUN
cord-011435-x73foqu7	307	3	block	block	VERB
cord-011435-x73foqu7	307	4	the	the	DET
cord-011435-x73foqu7	307	5	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	307	6	activity	activity	NOUN
cord-011435-x73foqu7	307	7	of	of	ADP
cord-011435-x73foqu7	307	8	irf3	irf3	PROPN
cord-011435-x73foqu7	307	9	to	to	PART
cord-011435-x73foqu7	307	10	dampen	dampen	VERB
cord-011435-x73foqu7	307	11	ifn	ifn	ADJ
cord-011435-x73foqu7	307	12	production	production	NOUN
cord-011435-x73foqu7	307	13	[	[	PUNCT
cord-011435-x73foqu7	307	14	45	45	NUM
cord-011435-x73foqu7	307	15	]	]	PUNCT
cord-011435-x73foqu7	307	16	.	.	PUNCT
cord-011435-x73foqu7	308	1	in	in	ADP
cord-011435-x73foqu7	308	2	such	such	ADJ
cord-011435-x73foqu7	308	3	scenarios	scenario	NOUN
cord-011435-x73foqu7	308	4	,	,	PUNCT
cord-011435-x73foqu7	308	5	it	it	PRON
cord-011435-x73foqu7	308	6	will	will	AUX
cord-011435-x73foqu7	308	7	be	be	AUX
cord-011435-x73foqu7	308	8	interesting	interesting	ADJ
cord-011435-x73foqu7	308	9	to	to	PART
cord-011435-x73foqu7	308	10	examine	examine	VERB
cord-011435-x73foqu7	308	11	whether	whether	SCONJ
cord-011435-x73foqu7	308	12	ripa	ripa	ADV
cord-011435-x73foqu7	308	13	-	-	PUNCT
cord-011435-x73foqu7	308	14	promoting	promote	VERB
cord-011435-x73foqu7	308	15	compounds	compound	NOUN
cord-011435-x73foqu7	308	16	inhibit	inhibit	VERB
cord-011435-x73foqu7	308	17	virus	virus	NOUN
cord-011435-x73foqu7	308	18	replication	replication	NOUN
cord-011435-x73foqu7	308	19	.	.	PUNCT
cord-011435-x73foqu7	309	1	to	to	PART
cord-011435-x73foqu7	309	2	investigate	investigate	VERB
cord-011435-x73foqu7	309	3	the	the	DET
cord-011435-x73foqu7	309	4	molecular	molecular	ADJ
cord-011435-x73foqu7	309	5	mechanisms	mechanism	NOUN
cord-011435-x73foqu7	309	6	of	of	ADP
cord-011435-x73foqu7	309	7	the	the	DET
cord-011435-x73foqu7	309	8	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	309	9	-	-	PUNCT
cord-011435-x73foqu7	309	10	mediated	mediate	VERB
cord-011435-x73foqu7	309	11	promotion	promotion	NOUN
cord-011435-x73foqu7	309	12	of	of	ADP
cord-011435-x73foqu7	309	13	ripa	ripa	PROPN
cord-011435-x73foqu7	309	14	,	,	PUNCT
cord-011435-x73foqu7	309	15	we	we	PRON
cord-011435-x73foqu7	309	16	examined	examine	VERB
cord-011435-x73foqu7	309	17	the	the	DET
cord-011435-x73foqu7	309	18	key	key	ADJ
cord-011435-x73foqu7	309	19	biochemical	biochemical	ADJ
cord-011435-x73foqu7	309	20	steps	step	NOUN
cord-011435-x73foqu7	309	21	of	of	ADP
cord-011435-x73foqu7	309	22	the	the	DET
cord-011435-x73foqu7	309	23	pathway	pathway	NOUN
cord-011435-x73foqu7	309	24	.	.	PUNCT
cord-011435-x73foqu7	310	1	since	since	SCONJ
cord-011435-x73foqu7	310	2	viruses	virus	NOUN
cord-011435-x73foqu7	310	3	can	can	AUX
cord-011435-x73foqu7	310	4	block	block	VERB
cord-011435-x73foqu7	310	5	host	host	NOUN
cord-011435-x73foqu7	310	6	pathways	pathway	NOUN
cord-011435-x73foqu7	310	7	,	,	PUNCT
cord-011435-x73foqu7	310	8	we	we	PRON
cord-011435-x73foqu7	310	9	chose	choose	VERB
cord-011435-x73foqu7	310	10	to	to	PART
cord-011435-x73foqu7	310	11	use	use	VERB
cord-011435-x73foqu7	310	12	nonviral	nonviral	ADJ
cord-011435-x73foqu7	310	13	stimuli	stimulus	NOUN
cord-011435-x73foqu7	310	14	of	of	ADP
cord-011435-x73foqu7	310	15	rlr	rlr	NOUN
cord-011435-x73foqu7	310	16	for	for	ADP
cord-011435-x73foqu7	310	17	the	the	DET
cord-011435-x73foqu7	310	18	mechanistic	mechanistic	ADJ
cord-011435-x73foqu7	310	19	studies	study	NOUN
cord-011435-x73foqu7	310	20	,	,	PUNCT
cord-011435-x73foqu7	310	21	to	to	PART
cord-011435-x73foqu7	310	22	avoid	avoid	VERB
cord-011435-x73foqu7	310	23	any	any	DET
cord-011435-x73foqu7	310	24	virus	virus	NOUN
cord-011435-x73foqu7	310	25	-	-	PUNCT
cord-011435-x73foqu7	310	26	specific	specific	ADJ
cord-011435-x73foqu7	310	27	effects	effect	NOUN
cord-011435-x73foqu7	310	28	.	.	PUNCT
cord-011435-x73foqu7	311	1	our	our	PRON
cord-011435-x73foqu7	311	2	results	result	NOUN
cord-011435-x73foqu7	311	3	indicate	indicate	VERB
cord-011435-x73foqu7	311	4	that	that	SCONJ
cord-011435-x73foqu7	311	5	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	311	6	did	do	AUX
cord-011435-x73foqu7	311	7	not	not	PART
cord-011435-x73foqu7	311	8	enhance	enhance	VERB
cord-011435-x73foqu7	311	9	the	the	DET
cord-011435-x73foqu7	311	10	irf3	irf3	PROPN
cord-011435-x73foqu7	311	11	ubiquitination	ubiquitination	NOUN
cord-011435-x73foqu7	311	12	nor	nor	CCONJ
cord-011435-x73foqu7	311	13	the	the	DET
cord-011435-x73foqu7	311	14	release	release	NOUN
cord-011435-x73foqu7	311	15	of	of	ADP
cord-011435-x73foqu7	311	16	cytochrome	cytochrome	NOUN
cord-011435-x73foqu7	311	17	c	c	PROPN
cord-011435-x73foqu7	311	18	into	into	ADP
cord-011435-x73foqu7	311	19	the	the	DET
cord-011435-x73foqu7	311	20	cytosol	cytosol	NOUN
cord-011435-x73foqu7	311	21	,	,	PUNCT
cord-011435-x73foqu7	311	22	the	the	DET
cord-011435-x73foqu7	311	23	critical	critical	ADJ
cord-011435-x73foqu7	311	24	stages	stage	NOUN
cord-011435-x73foqu7	311	25	of	of	ADP
cord-011435-x73foqu7	311	26	ripa	ripa	PROPN
cord-011435-x73foqu7	311	27	.	.	PUNCT
cord-011435-x73foqu7	312	1	interestingly	interestingly	ADV
cord-011435-x73foqu7	312	2	,	,	PUNCT
cord-011435-x73foqu7	312	3	our	our	PRON
cord-011435-x73foqu7	312	4	results	result	NOUN
cord-011435-x73foqu7	312	5	suggest	suggest	VERB
cord-011435-x73foqu7	312	6	that	that	SCONJ
cord-011435-x73foqu7	312	7	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	312	8	treatment	treatment	NOUN
cord-011435-x73foqu7	312	9	may	may	AUX
cord-011435-x73foqu7	312	10	enrich	enrich	VERB
cord-011435-x73foqu7	312	11	a	a	DET
cord-011435-x73foqu7	312	12	distinct	distinct	ADJ
cord-011435-x73foqu7	312	13	pool	pool	NOUN
cord-011435-x73foqu7	312	14	of	of	ADP
cord-011435-x73foqu7	312	15	ubiquitinated	ubiquitinated	ADJ
cord-011435-x73foqu7	312	16	irf3	irf3	PROPN
cord-011435-x73foqu7	312	17	in	in	ADP
cord-011435-x73foqu7	312	18	the	the	DET
cord-011435-x73foqu7	312	19	rlr	rlr	NOUN
cord-011435-x73foqu7	312	20	-	-	PUNCT
cord-011435-x73foqu7	312	21	stimulated	stimulate	VERB
cord-011435-x73foqu7	312	22	cells	cell	NOUN
cord-011435-x73foqu7	312	23	.	.	PUNCT
cord-011435-x73foqu7	313	1	targeted	target	VERB
cord-011435-x73foqu7	313	2	proteomic	proteomic	ADJ
cord-011435-x73foqu7	313	3	analyses	analysis	NOUN
cord-011435-x73foqu7	313	4	of	of	ADP
cord-011435-x73foqu7	313	5	this	this	DET
cord-011435-x73foqu7	313	6	pool	pool	NOUN
cord-011435-x73foqu7	313	7	of	of	ADP
cord-011435-x73foqu7	313	8	irf3	irf3	PROPN
cord-011435-x73foqu7	313	9	will	will	AUX
cord-011435-x73foqu7	313	10	be	be	AUX
cord-011435-x73foqu7	313	11	done	do	VERB
cord-011435-x73foqu7	313	12	in	in	ADP
cord-011435-x73foqu7	313	13	the	the	DET
cord-011435-x73foqu7	313	14	future	future	NOUN
cord-011435-x73foqu7	313	15	to	to	PART
cord-011435-x73foqu7	313	16	gain	gain	VERB
cord-011435-x73foqu7	313	17	further	further	ADJ
cord-011435-x73foqu7	313	18	insight	insight	NOUN
cord-011435-x73foqu7	313	19	.	.	PUNCT
cord-011435-x73foqu7	314	1	we	we	PRON
cord-011435-x73foqu7	314	2	also	also	ADV
cord-011435-x73foqu7	314	3	considered	consider	VERB
cord-011435-x73foqu7	314	4	that	that	SCONJ
cord-011435-x73foqu7	314	5	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	314	6	,	,	PUNCT
cord-011435-x73foqu7	314	7	a	a	DET
cord-011435-x73foqu7	314	8	dna	dna	NOUN
cord-011435-x73foqu7	314	9	-	-	PUNCT
cord-011435-x73foqu7	314	10	damaging	damaging	ADJ
cord-011435-x73foqu7	314	11	agent	agent	NOUN
cord-011435-x73foqu7	314	12	,	,	PUNCT
cord-011435-x73foqu7	314	13	might	might	AUX
cord-011435-x73foqu7	314	14	stimulate	stimulate	VERB
cord-011435-x73foqu7	314	15	ripa	ripa	NOUN
cord-011435-x73foqu7	314	16	by	by	ADP
cord-011435-x73foqu7	314	17	triggering	trigger	VERB
cord-011435-x73foqu7	314	18	the	the	DET
cord-011435-x73foqu7	314	19	sting	sting	NOUN
cord-011435-x73foqu7	314	20	signaling	signal	VERB
cord-011435-x73foqu7	314	21	pathway	pathway	NOUN
cord-011435-x73foqu7	314	22	via	via	ADP
cord-011435-x73foqu7	314	23	topoisomerase	topoisomerase	NOUN
cord-011435-x73foqu7	314	24	activation	activation	NOUN
cord-011435-x73foqu7	314	25	[	[	PUNCT
cord-011435-x73foqu7	314	26	46	46	NUM
cord-011435-x73foqu7	314	27	,	,	PUNCT
cord-011435-x73foqu7	314	28	47	47	NUM
cord-011435-x73foqu7	314	29	]	]	PUNCT
cord-011435-x73foqu7	314	30	.	.	PUNCT
cord-011435-x73foqu7	315	1	the	the	DET
cord-011435-x73foqu7	315	2	cgas	cgas	ADJ
cord-011435-x73foqu7	315	3	/	/	SYM
cord-011435-x73foqu7	315	4	sting	sting	ADJ
cord-011435-x73foqu7	315	5	pathway	pathway	NOUN
cord-011435-x73foqu7	315	6	can	can	AUX
cord-011435-x73foqu7	315	7	also	also	ADV
cord-011435-x73foqu7	315	8	trigger	trigger	VERB
cord-011435-x73foqu7	315	9	transcription	transcription	NOUN
cord-011435-x73foqu7	315	10	-	-	PUNCT
cord-011435-x73foqu7	315	11	independent	independent	ADJ
cord-011435-x73foqu7	315	12	mitotic	mitotic	ADJ
cord-011435-x73foqu7	315	13	cell	cell	NOUN
cord-011435-x73foqu7	315	14	death	death	NOUN
cord-011435-x73foqu7	315	15	by	by	ADP
cord-011435-x73foqu7	315	16	irf3	irf3	PROPN
cord-011435-x73foqu7	315	17	activation	activation	NOUN
cord-011435-x73foqu7	315	18	[	[	X
cord-011435-x73foqu7	315	19	48	48	NUM
cord-011435-x73foqu7	315	20	]	]	PUNCT
cord-011435-x73foqu7	315	21	.	.	PUNCT
cord-011435-x73foqu7	316	1	moreover	moreover	ADV
cord-011435-x73foqu7	316	2	,	,	PUNCT
cord-011435-x73foqu7	316	3	er	er	INTJ
cord-011435-x73foqu7	316	4	stress	stress	NOUN
cord-011435-x73foqu7	316	5	-	-	PUNCT
cord-011435-x73foqu7	316	6	activated	activate	VERB
cord-011435-x73foqu7	316	7	sting	sting	NOUN
cord-011435-x73foqu7	316	8	has	have	AUX
cord-011435-x73foqu7	316	9	been	be	AUX
cord-011435-x73foqu7	316	10	shown	show	VERB
cord-011435-x73foqu7	316	11	to	to	PART
cord-011435-x73foqu7	316	12	trigger	trigger	VERB
cord-011435-x73foqu7	316	13	a	a	DET
cord-011435-x73foqu7	316	14	ripa	ripa	ADJ
cord-011435-x73foqu7	316	15	-	-	PUNCT
cord-011435-x73foqu7	316	16	like	like	ADJ
cord-011435-x73foqu7	316	17	pathway	pathway	NOUN
cord-011435-x73foqu7	316	18	in	in	ADP
cord-011435-x73foqu7	316	19	hepatocytes	hepatocyte	NOUN
cord-011435-x73foqu7	316	20	[	[	X
cord-011435-x73foqu7	316	21	17	17	NUM
cord-011435-x73foqu7	316	22	]	]	PUNCT
cord-011435-x73foqu7	316	23	.	.	PUNCT
cord-011435-x73foqu7	317	1	however	however	ADV
cord-011435-x73foqu7	317	2	,	,	PUNCT
cord-011435-x73foqu7	317	3	in	in	ADP
cord-011435-x73foqu7	317	4	our	our	PRON
cord-011435-x73foqu7	317	5	test	test	NOUN
cord-011435-x73foqu7	317	6	cells	cell	NOUN
cord-011435-x73foqu7	317	7	,	,	PUNCT
cord-011435-x73foqu7	317	8	mda	mda	PROPN
cord-011435-x73foqu7	317	9	-	-	PUNCT
cord-011435-x73foqu7	317	10	mb-453	mb-453	NOUN
cord-011435-x73foqu7	317	11	,	,	PUNCT
cord-011435-x73foqu7	317	12	the	the	DET
cord-011435-x73foqu7	317	13	sting	sting	ADJ
cord-011435-x73foqu7	317	14	agonists	agonist	NOUN
cord-011435-x73foqu7	317	15	were	be	AUX
cord-011435-x73foqu7	317	16	unable	unable	ADJ
cord-011435-x73foqu7	317	17	to	to	PART
cord-011435-x73foqu7	317	18	trigger	trigger	VERB
cord-011435-x73foqu7	317	19	apoptotic	apoptotic	ADJ
cord-011435-x73foqu7	317	20	cell	cell	NOUN
cord-011435-x73foqu7	317	21	death	death	NOUN
cord-011435-x73foqu7	317	22	,	,	PUNCT
cord-011435-x73foqu7	317	23	indicating	indicate	VERB
cord-011435-x73foqu7	317	24	a	a	DET
cord-011435-x73foqu7	317	25	lack	lack	NOUN
cord-011435-x73foqu7	317	26	of	of	ADP
cord-011435-x73foqu7	317	27	sting	sting	ADJ
cord-011435-x73foqu7	317	28	contribution	contribution	NOUN
cord-011435-x73foqu7	317	29	in	in	ADP
cord-011435-x73foqu7	317	30	promoting	promote	VERB
cord-011435-x73foqu7	317	31	ripa	ripa	NOUN
cord-011435-x73foqu7	317	32	.	.	PUNCT
cord-011435-x73foqu7	318	1	it	it	PRON
cord-011435-x73foqu7	318	2	remains	remain	VERB
cord-011435-x73foqu7	318	3	to	to	PART
cord-011435-x73foqu7	318	4	be	be	AUX
cord-011435-x73foqu7	318	5	seen	see	VERB
cord-011435-x73foqu7	318	6	whether	whether	SCONJ
cord-011435-x73foqu7	318	7	the	the	DET
cord-011435-x73foqu7	318	8	ripa	ripa	NOUN
cord-011435-x73foqu7	318	9	activators	activator	NOUN
cord-011435-x73foqu7	318	10	also	also	ADV
cord-011435-x73foqu7	318	11	trigger	trigger	VERB
cord-011435-x73foqu7	318	12	additional	additional	ADJ
cord-011435-x73foqu7	318	13	innate	innate	ADJ
cord-011435-x73foqu7	318	14	signaling	signaling	NOUN
cord-011435-x73foqu7	318	15	pathways	pathway	NOUN
cord-011435-x73foqu7	318	16	,	,	PUNCT
cord-011435-x73foqu7	318	17	e.g.	e.g.	ADV
cord-011435-x73foqu7	318	18	,	,	PUNCT
cord-011435-x73foqu7	318	19	nlrs	nlrs	NOUN
cord-011435-x73foqu7	318	20	to	to	PART
cord-011435-x73foqu7	318	21	amplify	amplify	VERB
cord-011435-x73foqu7	318	22	ripa	ripa	ADJ
cord-011435-x73foqu7	318	23	activity	activity	NOUN
cord-011435-x73foqu7	318	24	.	.	PUNCT
cord-011435-x73foqu7	319	1	our	our	PRON
cord-011435-x73foqu7	319	2	results	result	NOUN
cord-011435-x73foqu7	319	3	revealed	reveal	VERB
cord-011435-x73foqu7	319	4	a	a	DET
cord-011435-x73foqu7	319	5	novel	novel	ADJ
cord-011435-x73foqu7	319	6	role	role	NOUN
cord-011435-x73foqu7	319	7	of	of	ADP
cord-011435-x73foqu7	319	8	the	the	DET
cord-011435-x73foqu7	319	9	erk	erk	NOUN
cord-011435-x73foqu7	319	10	signaling	signal	VERB
cord-011435-x73foqu7	319	11	pathway	pathway	NOUN
cord-011435-x73foqu7	319	12	in	in	ADP
cord-011435-x73foqu7	319	13	regulating	regulate	VERB
cord-011435-x73foqu7	319	14	ripa	ripa	NOUN
cord-011435-x73foqu7	319	15	.	.	PUNCT
cord-011435-x73foqu7	320	1	sev	sev	NOUN
cord-011435-x73foqu7	320	2	infection	infection	NOUN
cord-011435-x73foqu7	320	3	activates	activate	VERB
cord-011435-x73foqu7	320	4	cellular	cellular	ADJ
cord-011435-x73foqu7	320	5	autophagy	autophagy	NOUN
cord-011435-x73foqu7	320	6	via	via	ADP
cord-011435-x73foqu7	320	7	the	the	DET
cord-011435-x73foqu7	320	8	erk	erk	PROPN
cord-011435-x73foqu7	320	9	signaling	signal	VERB
cord-011435-x73foqu7	320	10	pathway	pathway	NOUN
cord-011435-x73foqu7	320	11	to	to	PART
cord-011435-x73foqu7	320	12	trigger	trigger	VERB
cord-011435-x73foqu7	320	13	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	321	1	[	[	X
cord-011435-x73foqu7	321	2	49	49	NUM
cord-011435-x73foqu7	321	3	]	]	PUNCT
cord-011435-x73foqu7	321	4	.	.	PUNCT
cord-011435-x73foqu7	322	1	whether	whether	SCONJ
cord-011435-x73foqu7	322	2	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	322	3	or	or	CCONJ
cord-011435-x73foqu7	322	4	pyrvinium	pyrvinium	PROPN
cord-011435-x73foqu7	322	5	pamoate	pamoate	NOUN
cord-011435-x73foqu7	322	6	use	use	VERB
cord-011435-x73foqu7	322	7	a	a	DET
cord-011435-x73foqu7	322	8	similar	similar	ADJ
cord-011435-x73foqu7	322	9	mechanism	mechanism	NOUN
cord-011435-x73foqu7	322	10	to	to	PART
cord-011435-x73foqu7	322	11	promote	promote	VERB
cord-011435-x73foqu7	322	12	ripa	ripa	NOUN
cord-011435-x73foqu7	322	13	will	will	AUX
cord-011435-x73foqu7	322	14	require	require	VERB
cord-011435-x73foqu7	322	15	additional	additional	ADJ
cord-011435-x73foqu7	322	16	studies	study	NOUN
cord-011435-x73foqu7	322	17	.	.	PUNCT
cord-011435-x73foqu7	323	1	our	our	PRON
cord-011435-x73foqu7	323	2	results	result	NOUN
cord-011435-x73foqu7	323	3	further	far	ADV
cord-011435-x73foqu7	323	4	revealed	reveal	VERB
cord-011435-x73foqu7	323	5	that	that	SCONJ
cord-011435-x73foqu7	323	6	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	323	7	activated	activate	VERB
cord-011435-x73foqu7	323	8	both	both	PRON
cord-011435-x73foqu7	323	9	erk	erk	PROPN
cord-011435-x73foqu7	323	10	and	and	CCONJ
cord-011435-x73foqu7	323	11	jnk	jnk	PROPN
cord-011435-x73foqu7	323	12	signaling	signal	VERB
cord-011435-x73foqu7	323	13	pathways	pathway	NOUN
cord-011435-x73foqu7	323	14	in	in	ADP
cord-011435-x73foqu7	323	15	rlr	rlr	NOUN
cord-011435-x73foqu7	323	16	-	-	PUNCT
cord-011435-x73foqu7	323	17	stimulated	stimulate	VERB
cord-011435-x73foqu7	323	18	cells	cell	NOUN
cord-011435-x73foqu7	323	19	;	;	PUNCT
cord-011435-x73foqu7	323	20	however	however	ADV
cord-011435-x73foqu7	323	21	,	,	PUNCT
cord-011435-x73foqu7	323	22	jnk	jnk	PROPN
cord-011435-x73foqu7	323	23	activity	activity	NOUN
cord-011435-x73foqu7	323	24	was	be	AUX
cord-011435-x73foqu7	323	25	not	not	PART
cord-011435-x73foqu7	323	26	required	require	VERB
cord-011435-x73foqu7	323	27	for	for	ADP
cord-011435-x73foqu7	323	28	promoting	promote	VERB
cord-011435-x73foqu7	323	29	ripa	ripa	PROPN
cord-011435-x73foqu7	323	30	.	.	PUNCT
cord-011435-x73foqu7	324	1	in	in	ADP
cord-011435-x73foqu7	324	2	the	the	DET
cord-011435-x73foqu7	324	3	future	future	NOUN
cord-011435-x73foqu7	324	4	,	,	PUNCT
cord-011435-x73foqu7	324	5	in	in	ADP
cord-011435-x73foqu7	324	6	-	-	PUNCT
cord-011435-x73foqu7	324	7	depth	depth	NOUN
cord-011435-x73foqu7	324	8	genetic	genetic	ADJ
cord-011435-x73foqu7	324	9	studies	study	NOUN
cord-011435-x73foqu7	324	10	will	will	AUX
cord-011435-x73foqu7	324	11	reveal	reveal	VERB
cord-011435-x73foqu7	324	12	the	the	DET
cord-011435-x73foqu7	324	13	relative	relative	ADJ
cord-011435-x73foqu7	324	14	contribution	contribution	NOUN
cord-011435-x73foqu7	324	15	of	of	ADP
cord-011435-x73foqu7	324	16	erk	erk	PROPN
cord-011435-x73foqu7	324	17	and	and	CCONJ
cord-011435-x73foqu7	324	18	jnk	jnk	PROPN
cord-011435-x73foqu7	324	19	to	to	PART
cord-011435-x73foqu7	324	20	modulate	modulate	VERB
cord-011435-x73foqu7	324	21	ripa	ripa	NOUN
cord-011435-x73foqu7	324	22	.	.	PUNCT
cord-011435-x73foqu7	325	1	the	the	DET
cord-011435-x73foqu7	325	2	erk	erk	PROPN
cord-011435-x73foqu7	325	3	signaling	signal	VERB
cord-011435-x73foqu7	325	4	pathway	pathway	NOUN
cord-011435-x73foqu7	325	5	also	also	ADV
cord-011435-x73foqu7	325	6	regulates	regulate	VERB
cord-011435-x73foqu7	325	7	the	the	DET
cord-011435-x73foqu7	325	8	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	325	9	activity	activity	NOUN
cord-011435-x73foqu7	325	10	of	of	ADP
cord-011435-x73foqu7	325	11	irf3	irf3	PROPN
cord-011435-x73foqu7	325	12	[	[	PUNCT
cord-011435-x73foqu7	325	13	50	50	NUM
cord-011435-x73foqu7	325	14	]	]	PUNCT
cord-011435-x73foqu7	325	15	;	;	PUNCT
cord-011435-x73foqu7	325	16	whether	whether	SCONJ
cord-011435-x73foqu7	325	17	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	325	18	inhibits	inhibit	VERB
cord-011435-x73foqu7	325	19	the	the	DET
cord-011435-x73foqu7	325	20	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	325	21	activity	activity	NOUN
cord-011435-x73foqu7	325	22	of	of	ADP
cord-011435-x73foqu7	325	23	irf3	irf3	PROPN
cord-011435-x73foqu7	325	24	via	via	ADP
cord-011435-x73foqu7	325	25	erk	erk	PROPN
cord-011435-x73foqu7	325	26	will	will	AUX
cord-011435-x73foqu7	325	27	require	require	VERB
cord-011435-x73foqu7	325	28	future	future	ADJ
cord-011435-x73foqu7	325	29	investigation	investigation	NOUN
cord-011435-x73foqu7	325	30	.	.	PUNCT
cord-011435-x73foqu7	326	1	in	in	ADP
cord-011435-x73foqu7	326	2	the	the	DET
cord-011435-x73foqu7	326	3	future	future	NOUN
cord-011435-x73foqu7	326	4	,	,	PUNCT
cord-011435-x73foqu7	326	5	in	in	ADP
cord-011435-x73foqu7	326	6	vivo	vivo	ADJ
cord-011435-x73foqu7	326	7	studies	study	NOUN
cord-011435-x73foqu7	326	8	in	in	ADP
cord-011435-x73foqu7	326	9	the	the	DET
cord-011435-x73foqu7	326	10	context	context	NOUN
cord-011435-x73foqu7	326	11	of	of	ADP
cord-011435-x73foqu7	326	12	virus	virus	NOUN
cord-011435-x73foqu7	326	13	-	-	PUNCT
cord-011435-x73foqu7	326	14	infection	infection	NOUN
cord-011435-x73foqu7	326	15	will	will	AUX
cord-011435-x73foqu7	326	16	be	be	AUX
cord-011435-x73foqu7	326	17	required	require	VERB
cord-011435-x73foqu7	326	18	to	to	PART
cord-011435-x73foqu7	326	19	validate	validate	VERB
cord-011435-x73foqu7	326	20	the	the	DET
cord-011435-x73foqu7	326	21	in	in	X
cord-011435-x73foqu7	326	22	vitro	vitro	X
cord-011435-x73foqu7	326	23	findings	finding	NOUN
cord-011435-x73foqu7	326	24	regarding	regard	VERB
cord-011435-x73foqu7	326	25	the	the	DET
cord-011435-x73foqu7	326	26	erk	erk	NOUN
cord-011435-x73foqu7	326	27	signaling	signal	VERB
cord-011435-x73foqu7	326	28	mechanism	mechanism	NOUN
cord-011435-x73foqu7	326	29	of	of	ADP
cord-011435-x73foqu7	326	30	ripa	ripa	NOUN
cord-011435-x73foqu7	326	31	-	-	PUNCT
cord-011435-x73foqu7	326	32	activating	activate	VERB
cord-011435-x73foqu7	326	33	drugs	drug	NOUN
cord-011435-x73foqu7	326	34	.	.	PUNCT
cord-011435-x73foqu7	327	1	a	a	DET
cord-011435-x73foqu7	327	2	previous	previous	ADJ
cord-011435-x73foqu7	327	3	study	study	NOUN
cord-011435-x73foqu7	327	4	indicated	indicate	VERB
cord-011435-x73foqu7	327	5	that	that	SCONJ
cord-011435-x73foqu7	327	6	p53	p53	NOUN
cord-011435-x73foqu7	327	7	,	,	PUNCT
cord-011435-x73foqu7	327	8	which	which	PRON
cord-011435-x73foqu7	327	9	can	can	AUX
cord-011435-x73foqu7	327	10	be	be	AUX
cord-011435-x73foqu7	327	11	activated	activate	VERB
cord-011435-x73foqu7	327	12	by	by	ADP
cord-011435-x73foqu7	327	13	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	327	14	,	,	PUNCT
cord-011435-x73foqu7	327	15	is	be	AUX
cord-011435-x73foqu7	327	16	not	not	PART
cord-011435-x73foqu7	327	17	involved	involve	VERB
cord-011435-x73foqu7	327	18	in	in	ADP
cord-011435-x73foqu7	327	19	dsrna	dsrna	PROPN
cord-011435-x73foqu7	327	20	-	-	PUNCT
cord-011435-x73foqu7	327	21	induced	induce	VERB
cord-011435-x73foqu7	327	22	cell	cell	NOUN
cord-011435-x73foqu7	327	23	death	death	NOUN
cord-011435-x73foqu7	327	24	[	[	PUNCT
cord-011435-x73foqu7	327	25	31	31	NUM
cord-011435-x73foqu7	327	26	]	]	PUNCT
cord-011435-x73foqu7	327	27	.	.	PUNCT
cord-011435-x73foqu7	328	1	in	in	ADP
cord-011435-x73foqu7	328	2	previous	previous	ADJ
cord-011435-x73foqu7	328	3	studies	study	NOUN
cord-011435-x73foqu7	328	4	,	,	PUNCT
cord-011435-x73foqu7	328	5	we	we	PRON
cord-011435-x73foqu7	328	6	have	have	AUX
cord-011435-x73foqu7	328	7	shown	show	VERB
cord-011435-x73foqu7	328	8	that	that	SCONJ
cord-011435-x73foqu7	328	9	sev	sev	X
cord-011435-x73foqu7	328	10	-	-	PUNCT
cord-011435-x73foqu7	328	11	induced	induce	VERB
cord-011435-x73foqu7	328	12	ripa	ripa	NOUN
cord-011435-x73foqu7	328	13	is	be	AUX
cord-011435-x73foqu7	328	14	regulated	regulate	VERB
cord-011435-x73foqu7	328	15	by	by	ADP
cord-011435-x73foqu7	328	16	the	the	DET
cord-011435-x73foqu7	328	17	pi3k	pi3k	X
cord-011435-x73foqu7	328	18	/	/	SYM
cord-011435-x73foqu7	328	19	akt	akt	PROPN
cord-011435-x73foqu7	328	20	signaling	signal	VERB
cord-011435-x73foqu7	328	21	pathway	pathway	NOUN
cord-011435-x73foqu7	328	22	[	[	X
cord-011435-x73foqu7	328	23	15	15	NUM
cord-011435-x73foqu7	328	24	]	]	PUNCT
cord-011435-x73foqu7	328	25	.	.	PUNCT
cord-011435-x73foqu7	329	1	it	it	PRON
cord-011435-x73foqu7	329	2	remains	remain	VERB
cord-011435-x73foqu7	329	3	to	to	PART
cord-011435-x73foqu7	329	4	be	be	AUX
cord-011435-x73foqu7	329	5	seen	see	VERB
cord-011435-x73foqu7	329	6	,	,	PUNCT
cord-011435-x73foqu7	329	7	using	use	VERB
cord-011435-x73foqu7	329	8	nt	nt	PROPN
cord-011435-x73foqu7	329	9	-	-	PUNCT
cord-011435-x73foqu7	329	10	irf3	irf3	PROPN
cord-011435-x73foqu7	329	11	mutant	mutant	NOUN
cord-011435-x73foqu7	329	12	that	that	PRON
cord-011435-x73foqu7	329	13	specifically	specifically	ADV
cord-011435-x73foqu7	329	14	activates	activate	VERB
cord-011435-x73foqu7	329	15	ripa	ripa	ADJ
cord-011435-x73foqu7	329	16	,	,	PUNCT
cord-011435-x73foqu7	329	17	whether	whether	SCONJ
cord-011435-x73foqu7	329	18	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	329	19	also	also	ADV
cord-011435-x73foqu7	329	20	modulates	modulate	VERB
cord-011435-x73foqu7	329	21	the	the	DET
cord-011435-x73foqu7	329	22	p53	p53	NOUN
cord-011435-x73foqu7	329	23	and	and	CCONJ
cord-011435-x73foqu7	329	24	pi3k	pi3k	NUM
cord-011435-x73foqu7	329	25	pathways	pathway	NOUN
cord-011435-x73foqu7	329	26	to	to	PART
cord-011435-x73foqu7	329	27	promote	promote	VERB
cord-011435-x73foqu7	329	28	ripa	ripa	PROPN
cord-011435-x73foqu7	329	29	.	.	PUNCT
cord-011435-x73foqu7	330	1	our	our	PRON
cord-011435-x73foqu7	330	2	screen	screen	NOUN
cord-011435-x73foqu7	330	3	,	,	PUNCT
cord-011435-x73foqu7	330	4	using	use	VERB
cord-011435-x73foqu7	330	5	a	a	DET
cord-011435-x73foqu7	330	6	relatively	relatively	ADV
cord-011435-x73foqu7	330	7	small	small	ADJ
cord-011435-x73foqu7	330	8	library	library	NOUN
cord-011435-x73foqu7	330	9	of	of	ADP
cord-011435-x73foqu7	330	10	1200	1200	NUM
cord-011435-x73foqu7	330	11	compounds	compound	NOUN
cord-011435-x73foqu7	330	12	,	,	PUNCT
cord-011435-x73foqu7	330	13	revealed	reveal	VERB
cord-011435-x73foqu7	330	14	that	that	SCONJ
cord-011435-x73foqu7	330	15	a	a	DET
cord-011435-x73foqu7	330	16	number	number	NOUN
cord-011435-x73foqu7	330	17	of	of	ADP
cord-011435-x73foqu7	330	18	molecules	molecule	NOUN
cord-011435-x73foqu7	330	19	with	with	ADP
cord-011435-x73foqu7	330	20	diverse	diverse	ADJ
cord-011435-x73foqu7	330	21	therapeutic	therapeutic	ADJ
cord-011435-x73foqu7	330	22	activities	activity	NOUN
cord-011435-x73foqu7	330	23	promote	promote	VERB
cord-011435-x73foqu7	330	24	ripa	ripa	PROPN
cord-011435-x73foqu7	330	25	.	.	PUNCT
cord-011435-x73foqu7	331	1	in	in	ADP
cord-011435-x73foqu7	331	2	the	the	DET
cord-011435-x73foqu7	331	3	future	future	NOUN
cord-011435-x73foqu7	331	4	,	,	PUNCT
cord-011435-x73foqu7	331	5	we	we	PRON
cord-011435-x73foqu7	331	6	will	will	AUX
cord-011435-x73foqu7	331	7	expand	expand	VERB
cord-011435-x73foqu7	331	8	the	the	DET
cord-011435-x73foqu7	331	9	screen	screen	NOUN
cord-011435-x73foqu7	331	10	to	to	ADP
cord-011435-x73foqu7	331	11	larger	large	ADJ
cord-011435-x73foqu7	331	12	libraries	library	NOUN
cord-011435-x73foqu7	331	13	to	to	PART
cord-011435-x73foqu7	331	14	isolate	isolate	VERB
cord-011435-x73foqu7	331	15	additional	additional	ADJ
cord-011435-x73foqu7	331	16	novel	novel	ADJ
cord-011435-x73foqu7	331	17	ripa	ripa	NOUN
cord-011435-x73foqu7	331	18	-	-	PUNCT
cord-011435-x73foqu7	331	19	activating	activate	VERB
cord-011435-x73foqu7	331	20	compounds	compound	NOUN
cord-011435-x73foqu7	331	21	.	.	PUNCT
cord-011435-x73foqu7	332	1	in	in	ADP
cord-011435-x73foqu7	332	2	addition	addition	NOUN
cord-011435-x73foqu7	332	3	,	,	PUNCT
cord-011435-x73foqu7	332	4	a	a	DET
cord-011435-x73foqu7	332	5	screen	screen	NOUN
cord-011435-x73foqu7	332	6	using	use	VERB
cord-011435-x73foqu7	332	7	cells	cell	NOUN
cord-011435-x73foqu7	332	8	expressing	express	VERB
cord-011435-x73foqu7	332	9	nt	nt	PROPN
cord-011435-x73foqu7	332	10	-	-	PUNCT
cord-011435-x73foqu7	332	11	irf3	irf3	PROPN
cord-011435-x73foqu7	332	12	mutant	mutant	NOUN
cord-011435-x73foqu7	332	13	that	that	PRON
cord-011435-x73foqu7	332	14	specifically	specifically	ADV
cord-011435-x73foqu7	332	15	activates	activate	VERB
cord-011435-x73foqu7	332	16	ripa	ripa	NOUN
cord-011435-x73foqu7	332	17	may	may	AUX
cord-011435-x73foqu7	332	18	reveal	reveal	VERB
cord-011435-x73foqu7	332	19	additional	additional	ADJ
cord-011435-x73foqu7	332	20	candidates	candidate	NOUN
cord-011435-x73foqu7	332	21	.	.	PUNCT
cord-011435-x73foqu7	333	1	in	in	ADP
cord-011435-x73foqu7	333	2	the	the	DET
cord-011435-x73foqu7	333	3	future	future	NOUN
cord-011435-x73foqu7	333	4	,	,	PUNCT
cord-011435-x73foqu7	333	5	we	we	PRON
cord-011435-x73foqu7	333	6	will	will	AUX
cord-011435-x73foqu7	333	7	use	use	VERB
cord-011435-x73foqu7	333	8	mice	mouse	NOUN
cord-011435-x73foqu7	333	9	expressing	express	VERB
cord-011435-x73foqu7	333	10	a	a	DET
cord-011435-x73foqu7	333	11	ripa	ripa	VERB
cord-011435-x73foqu7	333	12	-	-	PUNCT
cord-011435-x73foqu7	333	13	active	active	ADJ
cord-011435-x73foqu7	333	14	irf3	irf3	PROPN
cord-011435-x73foqu7	333	15	s1	s1	PROPN
cord-011435-x73foqu7	333	16	/	/	SYM
cord-011435-x73foqu7	333	17	s1	s1	PROPN
cord-011435-x73foqu7	333	18	mutant	mutant	NOUN
cord-011435-x73foqu7	333	19	to	to	PART
cord-011435-x73foqu7	333	20	test	test	VERB
cord-011435-x73foqu7	333	21	the	the	DET
cord-011435-x73foqu7	333	22	efficacy	efficacy	NOUN
cord-011435-x73foqu7	333	23	of	of	ADP
cord-011435-x73foqu7	333	24	the	the	DET
cord-011435-x73foqu7	333	25	ripa	ripa	NOUN
cord-011435-x73foqu7	333	26	-	-	PUNCT
cord-011435-x73foqu7	333	27	promoting	promote	VERB
cord-011435-x73foqu7	333	28	drugs	drug	NOUN
cord-011435-x73foqu7	333	29	in	in	ADP
cord-011435-x73foqu7	333	30	mounting	mount	VERB
cord-011435-x73foqu7	333	31	antiviral	antiviral	ADJ
cord-011435-x73foqu7	333	32	responses	response	NOUN
cord-011435-x73foqu7	333	33	in	in	ADP
cord-011435-x73foqu7	333	34	the	the	DET
cord-011435-x73foqu7	333	35	absence	absence	NOUN
cord-011435-x73foqu7	333	36	of	of	ADP
cord-011435-x73foqu7	333	37	antiviral	antiviral	ADJ
cord-011435-x73foqu7	333	38	genes	gene	NOUN
cord-011435-x73foqu7	333	39	.	.	PUNCT
cord-011435-x73foqu7	334	1	such	such	ADJ
cord-011435-x73foqu7	334	2	studies	study	NOUN
cord-011435-x73foqu7	334	3	will	will	AUX
cord-011435-x73foqu7	334	4	be	be	AUX
cord-011435-x73foqu7	334	5	physiologically	physiologically	ADV
cord-011435-x73foqu7	334	6	significant	significant	ADJ
cord-011435-x73foqu7	334	7	by	by	ADP
cord-011435-x73foqu7	334	8	using	use	VERB
cord-011435-x73foqu7	334	9	the	the	DET
cord-011435-x73foqu7	334	10	drug	drug	NOUN
cord-011435-x73foqu7	334	11	derivatives	derivative	NOUN
cord-011435-x73foqu7	334	12	that	that	PRON
cord-011435-x73foqu7	334	13	are	be	AUX
cord-011435-x73foqu7	334	14	currently	currently	ADV
cord-011435-x73foqu7	334	15	applied	apply	VERB
cord-011435-x73foqu7	334	16	on	on	ADP
cord-011435-x73foqu7	334	17	patients	patient	NOUN
cord-011435-x73foqu7	334	18	.	.	PUNCT
cord-011435-x73foqu7	335	1	because	because	SCONJ
cord-011435-x73foqu7	335	2	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	335	3	inhibits	inhibit	VERB
cord-011435-x73foqu7	335	4	the	the	DET
cord-011435-x73foqu7	335	5	cellular	cellular	ADJ
cord-011435-x73foqu7	335	6	ifn	ifn	ADJ
cord-011435-x73foqu7	335	7	response	response	NOUN
cord-011435-x73foqu7	335	8	,	,	PUNCT
cord-011435-x73foqu7	335	9	patients	patient	NOUN
cord-011435-x73foqu7	335	10	receiving	receive	VERB
cord-011435-x73foqu7	335	11	this	this	DET
cord-011435-x73foqu7	335	12	drug	drug	NOUN
cord-011435-x73foqu7	335	13	may	may	AUX
cord-011435-x73foqu7	335	14	be	be	AUX
cord-011435-x73foqu7	335	15	protected	protect	VERB
cord-011435-x73foqu7	335	16	from	from	ADP
cord-011435-x73foqu7	335	17	the	the	DET
cord-011435-x73foqu7	335	18	adverse	adverse	ADJ
cord-011435-x73foqu7	335	19	effects	effect	NOUN
cord-011435-x73foqu7	335	20	of	of	ADP
cord-011435-x73foqu7	335	21	ifn	ifn	NOUN
cord-011435-x73foqu7	335	22	and	and	CCONJ
cord-011435-x73foqu7	335	23	the	the	DET
cord-011435-x73foqu7	335	24	ifn	ifn	ADV
cord-011435-x73foqu7	335	25	-	-	PUNCT
cord-011435-x73foqu7	335	26	induced	induce	VERB
cord-011435-x73foqu7	335	27	genes	gene	NOUN
cord-011435-x73foqu7	335	28	.	.	PUNCT
cord-011435-x73foqu7	336	1	moreover	moreover	ADV
cord-011435-x73foqu7	336	2	,	,	PUNCT
cord-011435-x73foqu7	336	3	our	our	PRON
cord-011435-x73foqu7	336	4	study	study	NOUN
cord-011435-x73foqu7	336	5	provides	provide	VERB
cord-011435-x73foqu7	336	6	a	a	DET
cord-011435-x73foqu7	336	7	molecular	molecular	ADJ
cord-011435-x73foqu7	336	8	basis	basis	NOUN
cord-011435-x73foqu7	336	9	for	for	ADP
cord-011435-x73foqu7	336	10	the	the	DET
cord-011435-x73foqu7	336	11	previously	previously	ADV
cord-011435-x73foqu7	336	12	identified	identify	VERB
cord-011435-x73foqu7	336	13	antiviral	antiviral	ADJ
cord-011435-x73foqu7	336	14	effects	effect	NOUN
cord-011435-x73foqu7	336	15	of	of	ADP
cord-011435-x73foqu7	336	16	the	the	DET
cord-011435-x73foqu7	336	17	ripa	ripa	NOUN
cord-011435-x73foqu7	336	18	-	-	PUNCT
cord-011435-x73foqu7	336	19	activating	activate	VERB
cord-011435-x73foqu7	336	20	compounds	compound	NOUN
cord-011435-x73foqu7	336	21	[	[	PUNCT
cord-011435-x73foqu7	336	22	51	51	NUM
cord-011435-x73foqu7	336	23	,	,	PUNCT
cord-011435-x73foqu7	336	24	52	52	NUM
cord-011435-x73foqu7	336	25	]	]	PUNCT
cord-011435-x73foqu7	336	26	.	.	PUNCT
cord-011435-x73foqu7	337	1	a	a	DET
cord-011435-x73foqu7	337	2	recent	recent	ADJ
cord-011435-x73foqu7	337	3	study	study	NOUN
cord-011435-x73foqu7	337	4	showed	show	VERB
cord-011435-x73foqu7	337	5	that	that	SCONJ
cord-011435-x73foqu7	337	6	pp	pp	NOUN
cord-011435-x73foqu7	337	7	is	be	AUX
cord-011435-x73foqu7	337	8	a	a	DET
cord-011435-x73foqu7	337	9	novel	novel	ADJ
cord-011435-x73foqu7	337	10	inhibitor	inhibitor	NOUN
cord-011435-x73foqu7	337	11	of	of	ADP
cord-011435-x73foqu7	337	12	coronavirus	coronavirus	PROPN
cord-011435-x73foqu7	337	13	replication	replication	NOUN
cord-011435-x73foqu7	337	14	[	[	PUNCT
cord-011435-x73foqu7	337	15	53	53	NUM
cord-011435-x73foqu7	337	16	]	]	PUNCT
cord-011435-x73foqu7	337	17	and	and	CCONJ
cord-011435-x73foqu7	337	18	its	its	PRON
cord-011435-x73foqu7	337	19	antiviral	antiviral	ADJ
cord-011435-x73foqu7	337	20	property	property	NOUN
cord-011435-x73foqu7	337	21	,	,	PUNCT
cord-011435-x73foqu7	337	22	in	in	ADP
cord-011435-x73foqu7	337	23	part	part	NOUN
cord-011435-x73foqu7	337	24	,	,	PUNCT
cord-011435-x73foqu7	337	25	may	may	AUX
cord-011435-x73foqu7	337	26	be	be	AUX
cord-011435-x73foqu7	337	27	related	relate	VERB
cord-011435-x73foqu7	337	28	to	to	ADP
cord-011435-x73foqu7	337	29	the	the	DET
cord-011435-x73foqu7	337	30	ripa	ripa	ADV
cord-011435-x73foqu7	337	31	-	-	PUNCT
cord-011435-x73foqu7	337	32	promoting	promote	VERB
cord-011435-x73foqu7	337	33	function	function	NOUN
cord-011435-x73foqu7	337	34	of	of	ADP
cord-011435-x73foqu7	337	35	pp	pp	PROPN
cord-011435-x73foqu7	337	36	.	.	PUNCT
cord-011435-x73foqu7	338	1	whether	whether	SCONJ
cord-011435-x73foqu7	338	2	activation	activation	NOUN
cord-011435-x73foqu7	338	3	of	of	ADP
cord-011435-x73foqu7	338	4	ripa	ripa	PROPN
cord-011435-x73foqu7	338	5	directly	directly	ADV
cord-011435-x73foqu7	338	6	inhibits	inhibit	VERB
cord-011435-x73foqu7	338	7	virus	virus	NOUN
cord-011435-x73foqu7	338	8	replication	replication	NOUN
cord-011435-x73foqu7	338	9	or	or	CCONJ
cord-011435-x73foqu7	338	10	eliminates	eliminate	VERB
cord-011435-x73foqu7	338	11	the	the	DET
cord-011435-x73foqu7	338	12	virus	virus	NOUN
cord-011435-x73foqu7	338	13	-	-	PUNCT
cord-011435-x73foqu7	338	14	infected	infect	VERB
cord-011435-x73foqu7	338	15	cells	cell	NOUN
cord-011435-x73foqu7	338	16	to	to	PART
cord-011435-x73foqu7	338	17	reduce	reduce	VERB
cord-011435-x73foqu7	338	18	overall	overall	ADJ
cord-011435-x73foqu7	338	19	infection	infection	NOUN
cord-011435-x73foqu7	338	20	requires	require	VERB
cord-011435-x73foqu7	338	21	in	in	ADP
cord-011435-x73foqu7	338	22	-	-	PUNCT
cord-011435-x73foqu7	338	23	depth	depth	NOUN
cord-011435-x73foqu7	338	24	studies	study	NOUN
cord-011435-x73foqu7	338	25	.	.	PUNCT
cord-011435-x73foqu7	339	1	some	some	DET
cord-011435-x73foqu7	339	2	viruses	virus	NOUN
cord-011435-x73foqu7	339	3	trigger	trigger	VERB
cord-011435-x73foqu7	339	4	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	339	5	for	for	ADP
cord-011435-x73foqu7	339	6	successful	successful	ADJ
cord-011435-x73foqu7	339	7	spreading	spreading	NOUN
cord-011435-x73foqu7	339	8	and	and	CCONJ
cord-011435-x73foqu7	339	9	,	,	PUNCT
cord-011435-x73foqu7	339	10	therefore	therefore	ADV
cord-011435-x73foqu7	339	11	,	,	PUNCT
cord-011435-x73foqu7	339	12	promoting	promote	VERB
cord-011435-x73foqu7	339	13	viral	viral	ADJ
cord-011435-x73foqu7	339	14	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	339	15	to	to	PART
cord-011435-x73foqu7	339	16	inhibit	inhibit	VERB
cord-011435-x73foqu7	339	17	virus	virus	NOUN
cord-011435-x73foqu7	339	18	infection	infection	NOUN
cord-011435-x73foqu7	339	19	may	may	AUX
cord-011435-x73foqu7	339	20	be	be	AUX
cord-011435-x73foqu7	339	21	virus	virus	NOUN
cord-011435-x73foqu7	339	22	specific	specific	ADJ
cord-011435-x73foqu7	339	23	.	.	PUNCT
cord-011435-x73foqu7	340	1	finally	finally	ADV
cord-011435-x73foqu7	340	2	,	,	PUNCT
cord-011435-x73foqu7	340	3	a	a	DET
cord-011435-x73foqu7	340	4	strategy	strategy	NOUN
cord-011435-x73foqu7	340	5	to	to	PART
cord-011435-x73foqu7	340	6	repurpose	repurpose	VERB
cord-011435-x73foqu7	340	7	ripa	ripa	PROPN
cord-011435-x73foqu7	340	8	activators	activator	NOUN
cord-011435-x73foqu7	340	9	as	as	SCONJ
cord-011435-x73foqu7	340	10	antivirals	antiviral	NOUN
cord-011435-x73foqu7	340	11	must	must	AUX
cord-011435-x73foqu7	340	12	be	be	AUX
cord-011435-x73foqu7	340	13	met	meet	VERB
cord-011435-x73foqu7	340	14	with	with	ADP
cord-011435-x73foqu7	340	15	caution	caution	NOUN
cord-011435-x73foqu7	340	16	,	,	PUNCT
cord-011435-x73foqu7	340	17	as	as	SCONJ
cord-011435-x73foqu7	340	18	there	there	PRON
cord-011435-x73foqu7	340	19	are	be	VERB
cord-011435-x73foqu7	340	20	a	a	DET
cord-011435-x73foqu7	340	21	number	number	NOUN
cord-011435-x73foqu7	340	22	of	of	ADP
cord-011435-x73foqu7	340	23	diseases	disease	NOUN
cord-011435-x73foqu7	340	24	where	where	SCONJ
cord-011435-x73foqu7	340	25	ripa	ripa	PROPN
cord-011435-x73foqu7	340	26	can	can	AUX
cord-011435-x73foqu7	340	27	be	be	AUX
cord-011435-x73foqu7	340	28	detrimental	detrimental	ADJ
cord-011435-x73foqu7	340	29	(	(	PUNCT
cord-011435-x73foqu7	340	30	e.g.	e.g.	ADV
cord-011435-x73foqu7	340	31	,	,	PUNCT
cord-011435-x73foqu7	340	32	liver	liver	NOUN
cord-011435-x73foqu7	340	33	diseases	disease	NOUN
cord-011435-x73foqu7	340	34	)	)	PUNCT
cord-011435-x73foqu7	340	35	.	.	PUNCT
cord-011435-x73foqu7	341	1	for	for	ADP
cord-011435-x73foqu7	341	2	instance	instance	NOUN
cord-011435-x73foqu7	341	3	,	,	PUNCT
cord-011435-x73foqu7	341	4	a	a	DET
cord-011435-x73foqu7	341	5	ripa	ripa	VERB
cord-011435-x73foqu7	341	6	-	-	PUNCT
cord-011435-x73foqu7	341	7	like	like	ADJ
cord-011435-x73foqu7	341	8	pathway	pathway	NOUN
cord-011435-x73foqu7	341	9	in	in	ADP
cord-011435-x73foqu7	341	10	hepatocytes	hepatocyte	NOUN
cord-011435-x73foqu7	341	11	leads	lead	VERB
cord-011435-x73foqu7	341	12	to	to	ADP
cord-011435-x73foqu7	341	13	the	the	DET
cord-011435-x73foqu7	341	14	development	development	NOUN
cord-011435-x73foqu7	341	15	of	of	ADP
cord-011435-x73foqu7	341	16	alcoholic	alcoholic	ADJ
cord-011435-x73foqu7	341	17	liver	liver	NOUN
cord-011435-x73foqu7	341	18	diseases	disease	NOUN
cord-011435-x73foqu7	341	19	[	[	X
cord-011435-x73foqu7	341	20	17	17	NUM
cord-011435-x73foqu7	341	21	]	]	PUNCT
cord-011435-x73foqu7	341	22	.	.	PUNCT
cord-011435-x73foqu7	342	1	moreover	moreover	ADV
cord-011435-x73foqu7	342	2	,	,	PUNCT
cord-011435-x73foqu7	342	3	we	we	PRON
cord-011435-x73foqu7	342	4	recently	recently	ADV
cord-011435-x73foqu7	342	5	showed	show	VERB
cord-011435-x73foqu7	342	6	that	that	SCONJ
cord-011435-x73foqu7	342	7	ripa	ripa	NOUN
cord-011435-x73foqu7	342	8	-	-	PUNCT
cord-011435-x73foqu7	342	9	activated	activate	VERB
cord-011435-x73foqu7	342	10	hepatic	hepatic	PROPN
cord-011435-x73foqu7	342	11	myeloid	myeloid	PROPN
cord-011435-x73foqu7	342	12	cells	cell	NOUN
cord-011435-x73foqu7	342	13	produce	produce	VERB
cord-011435-x73foqu7	342	14	inflammatory	inflammatory	ADJ
cord-011435-x73foqu7	342	15	cytokines	cytokine	NOUN
cord-011435-x73foqu7	342	16	that	that	PRON
cord-011435-x73foqu7	342	17	cause	cause	VERB
cord-011435-x73foqu7	342	18	hepatitis	hepatitis	PROPN
cord-011435-x73foqu7	342	19	in	in	ADP
cord-011435-x73foqu7	342	20	mice	mouse	NOUN
cord-011435-x73foqu7	342	21	[	[	PUNCT
cord-011435-x73foqu7	342	22	18	18	NUM
cord-011435-x73foqu7	342	23	]	]	PUNCT
cord-011435-x73foqu7	342	24	.	.	PUNCT
cord-011435-x73foqu7	343	1	in	in	ADP
cord-011435-x73foqu7	343	2	these	these	DET
cord-011435-x73foqu7	343	3	scenarios	scenario	NOUN
cord-011435-x73foqu7	343	4	,	,	PUNCT
cord-011435-x73foqu7	343	5	it	it	PRON
cord-011435-x73foqu7	343	6	may	may	AUX
cord-011435-x73foqu7	343	7	be	be	AUX
cord-011435-x73foqu7	343	8	advantageous	advantageous	ADJ
cord-011435-x73foqu7	343	9	to	to	PART
cord-011435-x73foqu7	343	10	investigate	investigate	VERB
cord-011435-x73foqu7	343	11	ripa	ripa	ADJ
cord-011435-x73foqu7	343	12	inhibitors	inhibitor	NOUN
cord-011435-x73foqu7	343	13	as	as	ADP
cord-011435-x73foqu7	343	14	therapeutic	therapeutic	ADJ
cord-011435-x73foqu7	343	15	options	option	NOUN
cord-011435-x73foqu7	343	16	.	.	PUNCT
cord-011435-x73foqu7	344	1	in	in	ADP
cord-011435-x73foqu7	344	2	summary	summary	NOUN
cord-011435-x73foqu7	344	3	,	,	PUNCT
cord-011435-x73foqu7	344	4	our	our	PRON
cord-011435-x73foqu7	344	5	results	result	NOUN
cord-011435-x73foqu7	344	6	demonstrate	demonstrate	VERB
cord-011435-x73foqu7	344	7	that	that	SCONJ
cord-011435-x73foqu7	344	8	pharmacological	pharmacological	ADJ
cord-011435-x73foqu7	344	9	activation	activation	NOUN
cord-011435-x73foqu7	344	10	of	of	ADP
cord-011435-x73foqu7	344	11	ripa	ripa	NOUN
cord-011435-x73foqu7	344	12	may	may	AUX
cord-011435-x73foqu7	344	13	be	be	AUX
cord-011435-x73foqu7	344	14	a	a	DET
cord-011435-x73foqu7	344	15	potential	potential	ADJ
cord-011435-x73foqu7	344	16	antiviral	antiviral	ADJ
cord-011435-x73foqu7	344	17	strategy	strategy	NOUN
cord-011435-x73foqu7	344	18	,	,	PUNCT
cord-011435-x73foqu7	344	19	particularly	particularly	ADV
cord-011435-x73foqu7	344	20	in	in	ADP
cord-011435-x73foqu7	344	21	scenarios	scenario	NOUN
cord-011435-x73foqu7	344	22	where	where	SCONJ
cord-011435-x73foqu7	344	23	the	the	DET
cord-011435-x73foqu7	344	24	cellular	cellular	ADJ
cord-011435-x73foqu7	344	25	ifn	ifn	ADJ
cord-011435-x73foqu7	344	26	response	response	NOUN
cord-011435-x73foqu7	344	27	is	be	AUX
cord-011435-x73foqu7	344	28	dampened	dampen	VERB
cord-011435-x73foqu7	344	29	.	.	PUNCT
cord-011435-x73foqu7	345	1	in	in	ADP
cord-011435-x73foqu7	345	2	the	the	DET
cord-011435-x73foqu7	345	3	future	future	NOUN
cord-011435-x73foqu7	345	4	,	,	PUNCT
cord-011435-x73foqu7	345	5	these	these	DET
cord-011435-x73foqu7	345	6	ripa	ripa	ADJ
cord-011435-x73foqu7	345	7	-	-	PUNCT
cord-011435-x73foqu7	345	8	modulating	modulate	VERB
cord-011435-x73foqu7	345	9	agents	agent	NOUN
cord-011435-x73foqu7	345	10	can	can	AUX
cord-011435-x73foqu7	345	11	be	be	AUX
cord-011435-x73foqu7	345	12	studied	study	VERB
cord-011435-x73foqu7	345	13	in	in	ADP
cord-011435-x73foqu7	345	14	additional	additional	ADJ
cord-011435-x73foqu7	345	15	models	model	NOUN
cord-011435-x73foqu7	345	16	where	where	SCONJ
cord-011435-x73foqu7	345	17	ripa	ripa	PROPN
cord-011435-x73foqu7	345	18	is	be	AUX
cord-011435-x73foqu7	345	19	involved	involve	VERB
cord-011435-x73foqu7	345	20	,	,	PUNCT
cord-011435-x73foqu7	345	21	e.g.	e.g.	ADV
cord-011435-x73foqu7	345	22	,	,	PUNCT
cord-011435-x73foqu7	345	23	in	in	ADP
cord-011435-x73foqu7	345	24	fatty	fatty	ADJ
cord-011435-x73foqu7	345	25	liver	liver	NOUN
cord-011435-x73foqu7	345	26	diseases	disease	NOUN
cord-011435-x73foqu7	345	27	.	.	PUNCT
cord-011435-x73foqu7	346	1	supplementary	supplementary	ADJ
cord-011435-x73foqu7	346	2	materials	material	NOUN
cord-011435-x73foqu7	346	3	:	:	PUNCT
cord-011435-x73foqu7	346	4	the	the	DET
cord-011435-x73foqu7	346	5	following	follow	VERB
cord-011435-x73foqu7	346	6	are	be	AUX
cord-011435-x73foqu7	346	7	available	available	ADJ
cord-011435-x73foqu7	346	8	online	online	ADV
cord-011435-x73foqu7	346	9	at	at	ADP
cord-011435-x73foqu7	346	10	http://www.mdpi.com/1999-4915/12/4/442/s1	http://www.mdpi.com/1999-4915/12/4/442/s1	NOUN
cord-011435-x73foqu7	346	11	.	.	PUNCT
cord-011435-x73foqu7	347	1	figure	figure	NOUN
cord-011435-x73foqu7	347	2	s1	s1	PROPN
cord-011435-x73foqu7	347	3	.	.	PUNCT
cord-011435-x73foqu7	348	1	representative	representative	ADJ
cord-011435-x73foqu7	348	2	data	datum	NOUN
cord-011435-x73foqu7	348	3	from	from	ADP
cord-011435-x73foqu7	348	4	the	the	DET
cord-011435-x73foqu7	348	5	primary	primary	ADJ
cord-011435-x73foqu7	348	6	screen	screen	NOUN
cord-011435-x73foqu7	348	7	.	.	PUNCT
cord-011435-x73foqu7	349	1	a	a	DET
cord-011435-x73foqu7	349	2	representative	representative	ADJ
cord-011435-x73foqu7	349	3	primary	primary	NOUN
cord-011435-x73foqu7	349	4	screening	screen	VERB
cord-011435-x73foqu7	349	5	plate	plate	NOUN
cord-011435-x73foqu7	349	6	showing	show	VERB
cord-011435-x73foqu7	349	7	the	the	DET
cord-011435-x73foqu7	349	8	caspase-3	caspase-3	PROPN
cord-011435-x73foqu7	349	9	activity	activity	NOUN
cord-011435-x73foqu7	349	10	in	in	ADP
cord-011435-x73foqu7	349	11	each	each	DET
cord-011435-x73foqu7	349	12	well	well	ADV
cord-011435-x73foqu7	349	13	(	(	PUNCT
cord-011435-x73foqu7	349	14	rows	row	NOUN
cord-011435-x73foqu7	349	15	and	and	CCONJ
cord-011435-x73foqu7	349	16	columns	column	NOUN
cord-011435-x73foqu7	349	17	are	be	AUX
cord-011435-x73foqu7	349	18	shown	show	VERB
cord-011435-x73foqu7	349	19	in	in	ADP
cord-011435-x73foqu7	349	20	blue	blue	NOUN
cord-011435-x73foqu7	349	21	)	)	PUNCT
cord-011435-x73foqu7	349	22	containing	contain	VERB
cord-011435-x73foqu7	349	23	a	a	DET
cord-011435-x73foqu7	349	24	specific	specific	ADJ
cord-011435-x73foqu7	349	25	drug	drug	NOUN
cord-011435-x73foqu7	349	26	or	or	CCONJ
cord-011435-x73foqu7	349	27	dmso	dmso	ADJ
cord-011435-x73foqu7	349	28	(	(	PUNCT
cord-011435-x73foqu7	349	29	vehicle	vehicle	NOUN
cord-011435-x73foqu7	349	30	)	)	PUNCT
cord-011435-x73foqu7	349	31	control	control	NOUN
cord-011435-x73foqu7	349	32	.	.	PUNCT
cord-011435-x73foqu7	350	1	potential	potential	ADJ
cord-011435-x73foqu7	350	2	activator	activator	NOUN
cord-011435-x73foqu7	350	3	and	and	CCONJ
cord-011435-x73foqu7	350	4	inhibitor	inhibitor	NOUN
cord-011435-x73foqu7	350	5	drugs	drug	NOUN
cord-011435-x73foqu7	350	6	are	be	AUX
cord-011435-x73foqu7	350	7	shown	show	VERB
cord-011435-x73foqu7	350	8	in	in	ADP
cord-011435-x73foqu7	350	9	the	the	DET
cord-011435-x73foqu7	350	10	sample	sample	NOUN
cord-011435-x73foqu7	350	11	plate	plate	NOUN
cord-011435-x73foqu7	350	12	.	.	PUNCT
cord-011435-x73foqu7	351	1	nt	not	PART
cord-011435-x73foqu7	351	2	,	,	PUNCT
cord-011435-x73foqu7	351	3	no	no	DET
cord-011435-x73foqu7	351	4	treatment	treatment	NOUN
cord-011435-x73foqu7	351	5	.	.	PUNCT
cord-011435-x73foqu7	352	1	figure	figure	NOUN
cord-011435-x73foqu7	352	2	s2	s2	PROPN
cord-011435-x73foqu7	352	3	.	.	PUNCT
cord-011435-x73foqu7	353	1	validation	validation	NOUN
cord-011435-x73foqu7	353	2	of	of	ADP
cord-011435-x73foqu7	353	3	irf3−/−	irf3−/−	ADJ
cord-011435-x73foqu7	353	4	ht1080	ht1080	PROPN
cord-011435-x73foqu7	353	5	cells	cell	NOUN
cord-011435-x73foqu7	353	6	.	.	PUNCT
cord-011435-x73foqu7	354	1	immunoblot	immunoblot	NOUN
cord-011435-x73foqu7	354	2	of	of	ADP
cord-011435-x73foqu7	354	3	ifit3	ifit3	PROPN
cord-011435-x73foqu7	354	4	protein	protein	NOUN
cord-011435-x73foqu7	354	5	expression	expression	NOUN
cord-011435-x73foqu7	354	6	in	in	ADP
cord-011435-x73foqu7	354	7	rlr	rlr	NOUN
cord-011435-x73foqu7	354	8	-	-	PUNCT
cord-011435-x73foqu7	354	9	stimulated	stimulate	VERB
cord-011435-x73foqu7	354	10	wt	wt	NOUN
cord-011435-x73foqu7	354	11	and	and	CCONJ
cord-011435-x73foqu7	354	12	irf3−/−	irf3−/−	PROPN
cord-011435-x73foqu7	354	13	(	(	PUNCT
cord-011435-x73foqu7	354	14	ko	ko	PROPN
cord-011435-x73foqu7	354	15	)	)	PUNCT
cord-011435-x73foqu7	354	16	ht1080	ht1080	PROPN
cord-011435-x73foqu7	354	17	cells	cell	NOUN
cord-011435-x73foqu7	354	18	to	to	PART
cord-011435-x73foqu7	354	19	ensure	ensure	VERB
cord-011435-x73foqu7	354	20	the	the	DET
cord-011435-x73foqu7	354	21	gene	gene	NOUN
cord-011435-x73foqu7	354	22	knockout	knockout	NOUN
cord-011435-x73foqu7	354	23	.	.	PUNCT
cord-011435-x73foqu7	355	1	figure	figure	NOUN
cord-011435-x73foqu7	355	2	table	table	NOUN
cord-011435-x73foqu7	355	3	s1	s1	PROPN
cord-011435-x73foqu7	355	4	.	.	PUNCT
cord-011435-x73foqu7	356	1	caspase	caspase	NOUN
cord-011435-x73foqu7	356	2	activity	activity	NOUN
cord-011435-x73foqu7	356	3	of	of	ADP
cord-011435-x73foqu7	356	4	the	the	DET
cord-011435-x73foqu7	356	5	primary	primary	ADJ
cord-011435-x73foqu7	356	6	screening	screening	NOUN
cord-011435-x73foqu7	356	7	plates	plate	NOUN
cord-011435-x73foqu7	356	8	.	.	PUNCT
cord-011435-x73foqu7	357	1	mda	mda	ADJ
cord-011435-x73foqu7	357	2	-	-	PUNCT
cord-011435-x73foqu7	357	3	mb-453	mb-453	NOUN
cord-011435-x73foqu7	357	4	cells	cell	NOUN
cord-011435-x73foqu7	357	5	were	be	AUX
cord-011435-x73foqu7	357	6	transfected	transfecte	VERB
cord-011435-x73foqu7	357	7	with	with	ADP
cord-011435-x73foqu7	357	8	polyi	polyi	NOUN
cord-011435-x73foqu7	357	9	:	:	PUNCT
cord-011435-x73foqu7	357	10	c	c	X
cord-011435-x73foqu7	357	11	in	in	ADP
cord-011435-x73foqu7	357	12	the	the	DET
cord-011435-x73foqu7	357	13	absence	absence	NOUN
cord-011435-x73foqu7	357	14	or	or	CCONJ
cord-011435-x73foqu7	357	15	the	the	DET
cord-011435-x73foqu7	357	16	presence	presence	NOUN
cord-011435-x73foqu7	357	17	of	of	ADP
cord-011435-x73foqu7	357	18	the	the	DET
cord-011435-x73foqu7	357	19	drugs	drug	NOUN
cord-011435-x73foqu7	357	20	,	,	PUNCT
cord-011435-x73foqu7	357	21	as	as	SCONJ
cord-011435-x73foqu7	357	22	described	describe	VERB
cord-011435-x73foqu7	357	23	in	in	ADP
cord-011435-x73foqu7	357	24	figure	figure	NOUN
cord-011435-x73foqu7	357	25	1f	1f	NUM
cord-011435-x73foqu7	357	26	.	.	PUNCT
cord-011435-x73foqu7	358	1	caspase-3	caspase-3	NUM
cord-011435-x73foqu7	358	2	activity	activity	NOUN
cord-011435-x73foqu7	358	3	of	of	ADP
cord-011435-x73foqu7	358	4	each	each	DET
cord-011435-x73foqu7	358	5	well	well	ADV
cord-011435-x73foqu7	358	6	is	be	AUX
cord-011435-x73foqu7	358	7	indicated	indicate	VERB
cord-011435-x73foqu7	358	8	after	after	ADP
cord-011435-x73foqu7	358	9	normalizing	normalize	VERB
cord-011435-x73foqu7	358	10	to	to	ADP
cord-011435-x73foqu7	358	11	the	the	DET
cord-011435-x73foqu7	358	12	vehicle	vehicle	NOUN
cord-011435-x73foqu7	358	13	(	(	PUNCT
cord-011435-x73foqu7	358	14	dmso	dmso	NOUN
cord-011435-x73foqu7	358	15	)	)	PUNCT
cord-011435-x73foqu7	358	16	control	control	NOUN
cord-011435-x73foqu7	358	17	,	,	PUNCT
cord-011435-x73foqu7	358	18	which	which	PRON
cord-011435-x73foqu7	358	19	was	be	AUX
cord-011435-x73foqu7	358	20	considered	consider	VERB
cord-011435-x73foqu7	358	21	as	as	ADP
cord-011435-x73foqu7	358	22	100	100	NUM
cord-011435-x73foqu7	358	23	.	.	PUNCT
cord-011435-x73foqu7	359	1	author	author	NOUN
cord-011435-x73foqu7	359	2	contributions	contribution	NOUN
cord-011435-x73foqu7	359	3	:	:	PUNCT
cord-011435-x73foqu7	359	4	conceptualization	conceptualization	NOUN
cord-011435-x73foqu7	359	5	,	,	PUNCT
cord-011435-x73foqu7	359	6	s.c	s.c	PROPN
cord-011435-x73foqu7	359	7	.	.	PROPN
cord-011435-x73foqu7	359	8	and	and	CCONJ
cord-011435-x73foqu7	359	9	r.c	r.c	PROPN
cord-011435-x73foqu7	359	10	.	.	PROPN
cord-011435-x73foqu7	359	11	;	;	PUNCT
cord-011435-x73foqu7	359	12	methodology	methodology	NOUN
cord-011435-x73foqu7	359	13	,	,	PUNCT
cord-011435-x73foqu7	359	14	s.c	s.c	PROPN
cord-011435-x73foqu7	359	15	.	.	PROPN
cord-011435-x73foqu7	359	16	,	,	PUNCT
cord-011435-x73foqu7	359	17	a.g	a.g	PROPN
cord-011435-x73foqu7	359	18	.	.	PROPN
cord-011435-x73foqu7	359	19	,	,	PUNCT
cord-011435-x73foqu7	359	20	k.c	k.c	PROPN
cord-011435-x73foqu7	359	21	.	.	PROPN
cord-011435-x73foqu7	359	22	,	,	PUNCT
cord-011435-x73foqu7	359	23	s.f	s.f	PROPN
cord-011435-x73foqu7	359	24	.	.	PROPN
cord-011435-x73foqu7	359	25	,	,	PUNCT
cord-011435-x73foqu7	359	26	g.s	g.s	PROPN
cord-011435-x73foqu7	359	27	.	.	PROPN
cord-011435-x73foqu7	359	28	,	,	PUNCT
cord-011435-x73foqu7	359	29	j.g	j.g	PROPN
cord-011435-x73foqu7	359	30	.	.	PROPN
cord-011435-x73foqu7	359	31	,	,	PUNCT
cord-011435-x73foqu7	359	32	b.j	b.j	PROPN
cord-011435-x73foqu7	359	33	.	.	PROPN
cord-011435-x73foqu7	359	34	,	,	PUNCT
cord-011435-x73foqu7	359	35	j.c	j.c	PROPN
cord-011435-x73foqu7	359	36	.	.	PROPN
cord-011435-x73foqu7	359	37	and	and	CCONJ
cord-011435-x73foqu7	359	38	r.t.t	r.t.t	VERB
cord-011435-x73foqu7	359	39	.	.	PROPN
cord-011435-x73foqu7	359	40	;	;	PUNCT
cord-011435-x73foqu7	359	41	software	software	NOUN
cord-011435-x73foqu7	359	42	,	,	PUNCT
cord-011435-x73foqu7	359	43	s.c	s.c	PROPN
cord-011435-x73foqu7	359	44	.	.	PROPN
cord-011435-x73foqu7	359	45	,	,	PUNCT
cord-011435-x73foqu7	359	46	a.g	a.g	PROPN
cord-011435-x73foqu7	359	47	.	.	PROPN
cord-011435-x73foqu7	359	48	,	,	PUNCT
cord-011435-x73foqu7	359	49	and	and	CCONJ
cord-011435-x73foqu7	359	50	g.s	g.s	PROPN
cord-011435-x73foqu7	359	51	.	.	PROPN
cord-011435-x73foqu7	359	52	;	;	PUNCT
cord-011435-x73foqu7	359	53	validation	validation	NOUN
cord-011435-x73foqu7	359	54	,	,	PUNCT
cord-011435-x73foqu7	359	55	s.c	s.c	PROPN
cord-011435-x73foqu7	359	56	.	.	PROPN
cord-011435-x73foqu7	359	57	and	and	CCONJ
cord-011435-x73foqu7	359	58	a.g	a.g	PROPN
cord-011435-x73foqu7	359	59	.	.	PROPN
cord-011435-x73foqu7	359	60	;	;	PUNCT
cord-011435-x73foqu7	359	61	formal	formal	ADJ
cord-011435-x73foqu7	359	62	analysis	analysis	NOUN
cord-011435-x73foqu7	359	63	,	,	PUNCT
cord-011435-x73foqu7	359	64	s.c	s.c	PROPN
cord-011435-x73foqu7	359	65	.	.	PROPN
cord-011435-x73foqu7	359	66	,	,	PUNCT
cord-011435-x73foqu7	359	67	a.g	a.g	PROPN
cord-011435-x73foqu7	359	68	.	.	PROPN
cord-011435-x73foqu7	359	69	;	;	PUNCT
cord-011435-x73foqu7	359	70	investigation	investigation	NOUN
cord-011435-x73foqu7	359	71	,	,	PUNCT
cord-011435-x73foqu7	359	72	s.c	s.c	PROPN
cord-011435-x73foqu7	359	73	.	.	PROPN
cord-011435-x73foqu7	359	74	,	,	PUNCT
cord-011435-x73foqu7	359	75	a.g	a.g	PROPN
cord-011435-x73foqu7	359	76	.	.	PROPN
cord-011435-x73foqu7	359	77	,	,	PUNCT
cord-011435-x73foqu7	359	78	k.c	k.c	PROPN
cord-011435-x73foqu7	359	79	.	.	PROPN
cord-011435-x73foqu7	359	80	,	,	PUNCT
cord-011435-x73foqu7	359	81	s.f	s.f	PROPN
cord-011435-x73foqu7	359	82	.	.	PROPN
cord-011435-x73foqu7	359	83	,	,	PUNCT
cord-011435-x73foqu7	359	84	g.s	g.s	PROPN
cord-011435-x73foqu7	359	85	.	.	PROPN
cord-011435-x73foqu7	359	86	,	,	PUNCT
cord-011435-x73foqu7	359	87	j.g	j.g	PROPN
cord-011435-x73foqu7	359	88	.	.	PROPN
cord-011435-x73foqu7	359	89	,	,	PUNCT
cord-011435-x73foqu7	359	90	b.j	b.j	PROPN
cord-011435-x73foqu7	359	91	.	.	PROPN
cord-011435-x73foqu7	359	92	,	,	PUNCT
cord-011435-x73foqu7	359	93	j.c	j.c	PROPN
cord-011435-x73foqu7	359	94	.	.	PROPN
cord-011435-x73foqu7	359	95	and	and	CCONJ
cord-011435-x73foqu7	359	96	r.t.t	r.t.t	VERB
cord-011435-x73foqu7	359	97	.	.	PROPN
cord-011435-x73foqu7	359	98	;	;	PUNCT
cord-011435-x73foqu7	359	99	resources	resource	NOUN
cord-011435-x73foqu7	359	100	,	,	PUNCT
cord-011435-x73foqu7	359	101	s.c	s.c	PROPN
cord-011435-x73foqu7	359	102	.	.	PROPN
cord-011435-x73foqu7	359	103	,	,	PUNCT
cord-011435-x73foqu7	359	104	r.c	r.c	PROPN
cord-011435-x73foqu7	359	105	.	.	PROPN
cord-011435-x73foqu7	359	106	and	and	CCONJ
cord-011435-x73foqu7	359	107	r.t.t	r.t.t	VERB
cord-011435-x73foqu7	359	108	.	.	PROPN
cord-011435-x73foqu7	359	109	;	;	PUNCT
cord-011435-x73foqu7	359	110	data	datum	NOUN
cord-011435-x73foqu7	359	111	curation	curation	NOUN
cord-011435-x73foqu7	359	112	,	,	PUNCT
cord-011435-x73foqu7	359	113	s.c	s.c	PROPN
cord-011435-x73foqu7	359	114	.	.	PROPN
cord-011435-x73foqu7	359	115	,	,	PUNCT
cord-011435-x73foqu7	359	116	a.g	a.g	PROPN
cord-011435-x73foqu7	359	117	.	.	PROPN
cord-011435-x73foqu7	359	118	,	,	PUNCT
cord-011435-x73foqu7	359	119	k.c	k.c	PROPN
cord-011435-x73foqu7	359	120	.	.	PROPN
cord-011435-x73foqu7	359	121	,	,	PUNCT
cord-011435-x73foqu7	359	122	s.f	s.f	PROPN
cord-011435-x73foqu7	359	123	.	.	PROPN
cord-011435-x73foqu7	359	124	,	,	PUNCT
cord-011435-x73foqu7	359	125	g.s	g.s	PROPN
cord-011435-x73foqu7	359	126	.	.	PROPN
cord-011435-x73foqu7	359	127	,	,	PUNCT
cord-011435-x73foqu7	359	128	j.g	j.g	PROPN
cord-011435-x73foqu7	359	129	.	.	PROPN
cord-011435-x73foqu7	359	130	,	,	PUNCT
cord-011435-x73foqu7	359	131	b.j	b.j	PROPN
cord-011435-x73foqu7	359	132	.	.	PROPN
cord-011435-x73foqu7	359	133	,	,	PUNCT
cord-011435-x73foqu7	359	134	j.c	j.c	PROPN
cord-011435-x73foqu7	359	135	.	.	PROPN
cord-011435-x73foqu7	359	136	and	and	CCONJ
cord-011435-x73foqu7	359	137	r.t.t	r.t.t	VERB
cord-011435-x73foqu7	359	138	.	.	PUNCT
cord-011435-x73foqu7	359	139	;	;	PUNCT
cord-011435-x73foqu7	359	140	writing	writing	NOUN
cord-011435-x73foqu7	359	141	-	-	PUNCT
cord-011435-x73foqu7	359	142	original	original	ADJ
cord-011435-x73foqu7	359	143	draft	draft	NOUN
cord-011435-x73foqu7	359	144	preparation	preparation	NOUN
cord-011435-x73foqu7	359	145	,	,	PUNCT
cord-011435-x73foqu7	359	146	s.c	s.c	PROPN
cord-011435-x73foqu7	359	147	.	.	PROPN
cord-011435-x73foqu7	359	148	,	,	PUNCT
cord-011435-x73foqu7	359	149	a.g	a.g	PROPN
cord-011435-x73foqu7	359	150	.	.	PROPN
cord-011435-x73foqu7	359	151	and	and	CCONJ
cord-011435-x73foqu7	359	152	k.c	k.c	PROPN
cord-011435-x73foqu7	359	153	.	.	PROPN
cord-011435-x73foqu7	359	154	;	;	PUNCT
cord-011435-x73foqu7	359	155	writing	writing	NOUN
cord-011435-x73foqu7	359	156	-	-	PUNCT
cord-011435-x73foqu7	359	157	review	review	NOUN
cord-011435-x73foqu7	359	158	and	and	CCONJ
cord-011435-x73foqu7	359	159	editing	editing	NOUN
cord-011435-x73foqu7	359	160	,	,	PUNCT
cord-011435-x73foqu7	359	161	r.c	r.c	PROPN
cord-011435-x73foqu7	359	162	.	.	PROPN
cord-011435-x73foqu7	359	163	,	,	PUNCT
cord-011435-x73foqu7	359	164	and	and	CCONJ
cord-011435-x73foqu7	359	165	r.t.t	r.t.t	VERB
cord-011435-x73foqu7	359	166	.	.	PROPN
cord-011435-x73foqu7	359	167	;	;	PUNCT
cord-011435-x73foqu7	359	168	visualization	visualization	NOUN
cord-011435-x73foqu7	359	169	,	,	PUNCT
cord-011435-x73foqu7	359	170	s.c	s.c	PROPN
cord-011435-x73foqu7	359	171	.	.	PROPN
cord-011435-x73foqu7	359	172	,	,	PUNCT
cord-011435-x73foqu7	359	173	a.g	a.g	PROPN
cord-011435-x73foqu7	359	174	.	.	PROPN
cord-011435-x73foqu7	359	175	,	,	PUNCT
cord-011435-x73foqu7	359	176	k.c	k.c	PROPN
cord-011435-x73foqu7	359	177	.	.	PROPN
cord-011435-x73foqu7	359	178	,	,	PUNCT
cord-011435-x73foqu7	359	179	s.f	s.f	PROPN
cord-011435-x73foqu7	359	180	.	.	PROPN
cord-011435-x73foqu7	359	181	and	and	CCONJ
cord-011435-x73foqu7	359	182	g.s	g.s	PROPN
cord-011435-x73foqu7	359	183	.	.	PROPN
cord-011435-x73foqu7	359	184	;	;	PUNCT
cord-011435-x73foqu7	359	185	supervision	supervision	NOUN
cord-011435-x73foqu7	359	186	,	,	PUNCT
cord-011435-x73foqu7	359	187	s.c	s.c	PROPN
cord-011435-x73foqu7	359	188	.	.	PROPN
cord-011435-x73foqu7	359	189	,	,	PUNCT
cord-011435-x73foqu7	359	190	r.c	r.c	PROPN
cord-011435-x73foqu7	359	191	.	.	PROPN
cord-011435-x73foqu7	359	192	and	and	CCONJ
cord-011435-x73foqu7	359	193	r.t.t	r.t.t	VERB
cord-011435-x73foqu7	359	194	.	.	PROPN
cord-011435-x73foqu7	359	195	;	;	PUNCT
cord-011435-x73foqu7	359	196	project	project	NOUN
cord-011435-x73foqu7	359	197	administration	administration	NOUN
cord-011435-x73foqu7	359	198	,	,	PUNCT
cord-011435-x73foqu7	359	199	s.c	s.c	PROPN
cord-011435-x73foqu7	359	200	.	.	PROPN
cord-011435-x73foqu7	359	201	,	,	PUNCT
cord-011435-x73foqu7	359	202	r.c	r.c	PROPN
cord-011435-x73foqu7	359	203	.	.	PROPN
cord-011435-x73foqu7	359	204	and	and	CCONJ
cord-011435-x73foqu7	359	205	r.t.t	r.t.t	VERB
cord-011435-x73foqu7	359	206	.	.	PROPN
cord-011435-x73foqu7	359	207	;	;	PUNCT
cord-011435-x73foqu7	359	208	funding	funding	NOUN
cord-011435-x73foqu7	359	209	acquisition	acquisition	NOUN
cord-011435-x73foqu7	359	210	,	,	PUNCT
cord-011435-x73foqu7	359	211	s.c	s.c	PROPN
cord-011435-x73foqu7	359	212	.	.	PROPN
cord-011435-x73foqu7	359	213	and	and	CCONJ
cord-011435-x73foqu7	359	214	r.t.t	r.t.t	VERB
cord-011435-x73foqu7	359	215	.	.	PUNCT
cord-011435-x73foqu7	360	1	all	all	DET
cord-011435-x73foqu7	360	2	authors	author	NOUN
cord-011435-x73foqu7	360	3	have	have	AUX
cord-011435-x73foqu7	360	4	read	read	VERB
cord-011435-x73foqu7	360	5	and	and	CCONJ
cord-011435-x73foqu7	360	6	agreed	agree	VERB
cord-011435-x73foqu7	360	7	to	to	ADP
cord-011435-x73foqu7	360	8	the	the	DET
cord-011435-x73foqu7	360	9	published	publish	VERB
cord-011435-x73foqu7	360	10	version	version	NOUN
cord-011435-x73foqu7	360	11	of	of	ADP
cord-011435-x73foqu7	360	12	the	the	DET
cord-011435-x73foqu7	360	13	manuscript	manuscript	NOUN
cord-011435-x73foqu7	360	14	.	.	PUNCT
cord-011435-x73foqu7	361	1	no	no	DET
cord-011435-x73foqu7	361	2	love	love	NOUN
cord-011435-x73foqu7	361	3	lost	lose	VERB
cord-011435-x73foqu7	361	4	between	between	ADP
cord-011435-x73foqu7	361	5	viruses	virus	NOUN
cord-011435-x73foqu7	361	6	and	and	CCONJ
cord-011435-x73foqu7	361	7	interferons	interferon	VERB
cord-011435-x73foqu7	361	8	the	the	DET
cord-011435-x73foqu7	361	9	irf	irf	PROPN
cord-011435-x73foqu7	361	10	family	family	NOUN
cord-011435-x73foqu7	361	11	transcription	transcription	NOUN
cord-011435-x73foqu7	361	12	factors	factor	NOUN
cord-011435-x73foqu7	361	13	at	at	ADP
cord-011435-x73foqu7	361	14	the	the	DET
cord-011435-x73foqu7	361	15	interface	interface	NOUN
cord-011435-x73foqu7	361	16	of	of	ADP
cord-011435-x73foqu7	361	17	innate	innate	ADJ
cord-011435-x73foqu7	361	18	and	and	CCONJ
cord-011435-x73foqu7	361	19	adaptive	adaptive	ADJ
cord-011435-x73foqu7	361	20	immune	immune	ADJ
cord-011435-x73foqu7	361	21	responses	response	NOUN
cord-011435-x73foqu7	361	22	regulating	regulate	VERB
cord-011435-x73foqu7	361	23	irfs	irf	NOUN
cord-011435-x73foqu7	361	24	in	in	ADP
cord-011435-x73foqu7	361	25	ifn	ifn	PROPN
cord-011435-x73foqu7	361	26	driven	drive	VERB
cord-011435-x73foqu7	361	27	disease	disease	NOUN
cord-011435-x73foqu7	361	28	convergence	convergence	NOUN
cord-011435-x73foqu7	361	29	of	of	ADP
cord-011435-x73foqu7	361	30	the	the	DET
cord-011435-x73foqu7	361	31	nf	nf	NOUN
cord-011435-x73foqu7	361	32	-	-	PUNCT
cord-011435-x73foqu7	361	33	kappab	kappab	PROPN
cord-011435-x73foqu7	361	34	and	and	CCONJ
cord-011435-x73foqu7	361	35	irf	irf	PROPN
cord-011435-x73foqu7	361	36	pathways	pathway	NOUN
cord-011435-x73foqu7	361	37	in	in	ADP
cord-011435-x73foqu7	361	38	the	the	DET
cord-011435-x73foqu7	361	39	regulation	regulation	NOUN
cord-011435-x73foqu7	361	40	of	of	ADP
cord-011435-x73foqu7	361	41	the	the	DET
cord-011435-x73foqu7	361	42	innate	innate	ADJ
cord-011435-x73foqu7	361	43	antiviral	antiviral	ADJ
cord-011435-x73foqu7	361	44	response	response	NOUN
cord-011435-x73foqu7	361	45	interferon	interferon	NOUN
cord-011435-x73foqu7	361	46	-	-	PUNCT
cord-011435-x73foqu7	361	47	stimulated	stimulate	VERB
cord-011435-x73foqu7	361	48	genes	gene	NOUN
cord-011435-x73foqu7	361	49	and	and	CCONJ
cord-011435-x73foqu7	361	50	their	their	PRON
cord-011435-x73foqu7	361	51	antiviral	antiviral	ADJ
cord-011435-x73foqu7	361	52	effector	effector	NOUN
cord-011435-x73foqu7	361	53	functions	function	NOUN
cord-011435-x73foqu7	361	54	inhibition	inhibition	NOUN
cord-011435-x73foqu7	361	55	of	of	ADP
cord-011435-x73foqu7	361	56	viral	viral	ADJ
cord-011435-x73foqu7	361	57	pathogenesis	pathogenesis	NOUN
cord-011435-x73foqu7	361	58	and	and	CCONJ
cord-011435-x73foqu7	361	59	promotion	promotion	NOUN
cord-011435-x73foqu7	361	60	of	of	ADP
cord-011435-x73foqu7	361	61	the	the	DET
cord-011435-x73foqu7	361	62	septic	septic	ADJ
cord-011435-x73foqu7	361	63	shock	shock	NOUN
cord-011435-x73foqu7	361	64	response	response	NOUN
cord-011435-x73foqu7	361	65	to	to	ADP
cord-011435-x73foqu7	361	66	bacterial	bacterial	ADJ
cord-011435-x73foqu7	361	67	infection	infection	NOUN
cord-011435-x73foqu7	361	68	by	by	ADP
cord-011435-x73foqu7	361	69	irf-3	irf-3	PUNCT
cord-011435-x73foqu7	361	70	are	be	AUX
cord-011435-x73foqu7	361	71	regulated	regulate	VERB
cord-011435-x73foqu7	361	72	by	by	ADP
cord-011435-x73foqu7	361	73	the	the	DET
cord-011435-x73foqu7	361	74	acetylation	acetylation	NOUN
cord-011435-x73foqu7	361	75	and	and	CCONJ
cord-011435-x73foqu7	361	76	phosphorylation	phosphorylation	NOUN
cord-011435-x73foqu7	361	77	of	of	ADP
cord-011435-x73foqu7	361	78	its	its	PRON
cord-011435-x73foqu7	361	79	coactivators	coactivator	NOUN
cord-011435-x73foqu7	361	80	ubiquitination	ubiquitination	NOUN
cord-011435-x73foqu7	361	81	of	of	ADP
cord-011435-x73foqu7	361	82	the	the	DET
cord-011435-x73foqu7	361	83	transcription	transcription	NOUN
cord-011435-x73foqu7	361	84	factor	factor	NOUN
cord-011435-x73foqu7	361	85	irf-3	irf-3	PUNCT
cord-011435-x73foqu7	361	86	activates	activate	VERB
cord-011435-x73foqu7	361	87	ripa	ripa	ADJ
cord-011435-x73foqu7	361	88	,	,	PUNCT
cord-011435-x73foqu7	361	89	the	the	DET
cord-011435-x73foqu7	361	90	apoptotic	apoptotic	ADJ
cord-011435-x73foqu7	361	91	pathway	pathway	NOUN
cord-011435-x73foqu7	361	92	that	that	PRON
cord-011435-x73foqu7	361	93	protects	protect	VERB
cord-011435-x73foqu7	361	94	mice	mouse	NOUN
cord-011435-x73foqu7	361	95	from	from	ADP
cord-011435-x73foqu7	361	96	viral	viral	ADJ
cord-011435-x73foqu7	361	97	pathogenesis	pathogenesis	NOUN
cord-011435-x73foqu7	361	98	role	role	NOUN
cord-011435-x73foqu7	361	99	of	of	ADP
cord-011435-x73foqu7	361	100	interferon	interferon	ADJ
cord-011435-x73foqu7	361	101	regulatory	regulatory	ADJ
cord-011435-x73foqu7	361	102	factor	factor	NOUN
cord-011435-x73foqu7	361	103	3	3	NUM
cord-011435-x73foqu7	361	104	-	-	PUNCT
cord-011435-x73foqu7	361	105	mediated	mediate	VERB
cord-011435-x73foqu7	361	106	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	361	107	in	in	ADP
cord-011435-x73foqu7	361	108	the	the	DET
cord-011435-x73foqu7	361	109	establishment	establishment	NOUN
cord-011435-x73foqu7	361	110	and	and	CCONJ
cord-011435-x73foqu7	361	111	maintenance	maintenance	NOUN
cord-011435-x73foqu7	361	112	of	of	ADP
cord-011435-x73foqu7	361	113	persistent	persistent	ADJ
cord-011435-x73foqu7	361	114	infection	infection	NOUN
cord-011435-x73foqu7	361	115	by	by	ADP
cord-011435-x73foqu7	361	116	sendai	sendai	PROPN
cord-011435-x73foqu7	361	117	virus	virus	PROPN
cord-011435-x73foqu7	361	118	viral	viral	ADJ
cord-011435-x73foqu7	361	119	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	361	120	is	be	AUX
cord-011435-x73foqu7	361	121	induced	induce	VERB
cord-011435-x73foqu7	361	122	by	by	ADP
cord-011435-x73foqu7	361	123	irf-3	irf-3	PUNCT
cord-011435-x73foqu7	361	124	-	-	PUNCT
cord-011435-x73foqu7	361	125	mediated	mediate	VERB
cord-011435-x73foqu7	361	126	activation	activation	NOUN
cord-011435-x73foqu7	361	127	of	of	ADP
cord-011435-x73foqu7	361	128	bax	bax	PROPN
cord-011435-x73foqu7	361	129	irf-3	irf-3	PUNCT
cord-011435-x73foqu7	361	130	and	and	CCONJ
cord-011435-x73foqu7	361	131	bax	bax	PROPN
cord-011435-x73foqu7	361	132	:	:	PUNCT
cord-011435-x73foqu7	361	133	a	a	DET
cord-011435-x73foqu7	361	134	deadly	deadly	ADJ
cord-011435-x73foqu7	361	135	affair	affair	NOUN
cord-011435-x73foqu7	361	136	dsrna	dsrna	NOUN
cord-011435-x73foqu7	361	137	-	-	PUNCT
cord-011435-x73foqu7	361	138	activation	activation	NOUN
cord-011435-x73foqu7	361	139	of	of	ADP
cord-011435-x73foqu7	361	140	tlr3	tlr3	NOUN
cord-011435-x73foqu7	361	141	and	and	CCONJ
cord-011435-x73foqu7	361	142	rlr	rlr	NOUN
cord-011435-x73foqu7	361	143	signaling	signal	VERB
cord-011435-x73foqu7	361	144	:	:	PUNCT
cord-011435-x73foqu7	361	145	gene	gene	NOUN
cord-011435-x73foqu7	361	146	induction	induction	NOUN
cord-011435-x73foqu7	361	147	-	-	PUNCT
cord-011435-x73foqu7	361	148	dependent	dependent	ADJ
cord-011435-x73foqu7	361	149	and	and	CCONJ
cord-011435-x73foqu7	361	150	independent	independent	ADJ
cord-011435-x73foqu7	361	151	effects	effect	NOUN
cord-011435-x73foqu7	361	152	rig	rig	VERB
cord-011435-x73foqu7	361	153	-	-	PUNCT
cord-011435-x73foqu7	361	154	i	i	NOUN
cord-011435-x73foqu7	361	155	-	-	PUNCT
cord-011435-x73foqu7	361	156	like	like	ADJ
cord-011435-x73foqu7	361	157	receptor	receptor	NOUN
cord-011435-x73foqu7	361	158	-	-	PUNCT
cord-011435-x73foqu7	361	159	induced	induce	VERB
cord-011435-x73foqu7	361	160	irf3	irf3	NOUN
cord-011435-x73foqu7	361	161	mediated	mediate	VERB
cord-011435-x73foqu7	361	162	pathway	pathway	NOUN
cord-011435-x73foqu7	361	163	of	of	ADP
cord-011435-x73foqu7	361	164	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	361	165	(	(	PUNCT
cord-011435-x73foqu7	361	166	ripa	ripa	PROPN
cord-011435-x73foqu7	361	167	):	):	PUNCT
cord-011435-x73foqu7	361	168	a	a	DET
cord-011435-x73foqu7	361	169	new	new	ADJ
cord-011435-x73foqu7	361	170	antiviral	antiviral	ADJ
cord-011435-x73foqu7	361	171	pathway	pathway	NOUN
cord-011435-x73foqu7	361	172	the	the	DET
cord-011435-x73foqu7	361	173	irf-3	irf-3	PUNCT
cord-011435-x73foqu7	361	174	/	/	SYM
cord-011435-x73foqu7	361	175	bax	bax	NOUN
cord-011435-x73foqu7	361	176	-	-	PUNCT
cord-011435-x73foqu7	361	177	mediated	mediate	VERB
cord-011435-x73foqu7	361	178	apoptotic	apoptotic	ADJ
cord-011435-x73foqu7	361	179	pathway	pathway	NOUN
cord-011435-x73foqu7	361	180	,	,	PUNCT
cord-011435-x73foqu7	361	181	activated	activate	VERB
cord-011435-x73foqu7	361	182	by	by	ADP
cord-011435-x73foqu7	361	183	viral	viral	ADJ
cord-011435-x73foqu7	361	184	cytoplasmic	cytoplasmic	ADJ
cord-011435-x73foqu7	361	185	rna	rna	NOUN
cord-011435-x73foqu7	361	186	and	and	CCONJ
cord-011435-x73foqu7	361	187	dna	dna	PROPN
cord-011435-x73foqu7	361	188	,	,	PUNCT
cord-011435-x73foqu7	361	189	inhibits	inhibit	VERB
cord-011435-x73foqu7	361	190	virus	virus	NOUN
cord-011435-x73foqu7	361	191	replication	replication	NOUN
cord-011435-x73foqu7	361	192	irf-3	irf-3	PUNCT
cord-011435-x73foqu7	361	193	activation	activation	NOUN
cord-011435-x73foqu7	361	194	by	by	ADP
cord-011435-x73foqu7	361	195	sendai	sendai	PROPN
cord-011435-x73foqu7	361	196	virus	virus	PROPN
cord-011435-x73foqu7	361	197	infection	infection	NOUN
cord-011435-x73foqu7	361	198	is	be	AUX
cord-011435-x73foqu7	361	199	required	require	VERB
cord-011435-x73foqu7	361	200	for	for	ADP
cord-011435-x73foqu7	361	201	cellular	cellular	ADJ
cord-011435-x73foqu7	361	202	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	361	203	and	and	CCONJ
cord-011435-x73foqu7	361	204	avoidance	avoidance	NOUN
cord-011435-x73foqu7	361	205	of	of	ADP
cord-011435-x73foqu7	361	206	persistence	persistence	NOUN
cord-011435-x73foqu7	361	207	phosphatidylinositol	phosphatidylinositol	NOUN
cord-011435-x73foqu7	361	208	3	3	NUM
cord-011435-x73foqu7	361	209	-	-	PUNCT
cord-011435-x73foqu7	361	210	kinase	kinase	NOUN
cord-011435-x73foqu7	361	211	signaling	signal	VERB
cord-011435-x73foqu7	361	212	delays	delay	NOUN
cord-011435-x73foqu7	361	213	sendai	sendai	PROPN
cord-011435-x73foqu7	361	214	virus	virus	NOUN
cord-011435-x73foqu7	361	215	-	-	PUNCT
cord-011435-x73foqu7	361	216	induced	induce	VERB
cord-011435-x73foqu7	361	217	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	361	218	by	by	ADP
cord-011435-x73foqu7	361	219	preventing	prevent	VERB
cord-011435-x73foqu7	361	220	xiap	xiap	PROPN
cord-011435-x73foqu7	361	221	degradation	degradation	PROPN
cord-011435-x73foqu7	361	222	host	host	NOUN
cord-011435-x73foqu7	361	223	restriction	restriction	NOUN
cord-011435-x73foqu7	361	224	factor	factor	NOUN
cord-011435-x73foqu7	361	225	samhd1	samhd1	PROPN
cord-011435-x73foqu7	361	226	limits	limit	VERB
cord-011435-x73foqu7	361	227	human	human	ADJ
cord-011435-x73foqu7	361	228	t	t	PROPN
cord-011435-x73foqu7	361	229	cell	cell	NOUN
cord-011435-x73foqu7	361	230	leukemia	leukemia	NOUN
cord-011435-x73foqu7	361	231	virus	virus	NOUN
cord-011435-x73foqu7	361	232	type	type	NOUN
cord-011435-x73foqu7	361	233	1	1	NUM
cord-011435-x73foqu7	361	234	infection	infection	NOUN
cord-011435-x73foqu7	361	235	of	of	ADP
cord-011435-x73foqu7	361	236	monocytes	monocyte	NOUN
cord-011435-x73foqu7	361	237	via	via	ADP
cord-011435-x73foqu7	361	238	sting	ste	VERB
cord-011435-x73foqu7	361	239	-	-	PUNCT
cord-011435-x73foqu7	361	240	mediated	mediate	VERB
cord-011435-x73foqu7	361	241	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	361	242	sting	sting	NOUN
cord-011435-x73foqu7	361	243	-	-	PUNCT
cord-011435-x73foqu7	361	244	irf3	irf3	NOUN
cord-011435-x73foqu7	361	245	pathway	pathway	NOUN
cord-011435-x73foqu7	361	246	links	link	VERB
cord-011435-x73foqu7	361	247	endoplasmic	endoplasmic	ADJ
cord-011435-x73foqu7	361	248	reticulum	reticulum	NOUN
cord-011435-x73foqu7	361	249	stress	stress	NOUN
cord-011435-x73foqu7	361	250	with	with	ADP
cord-011435-x73foqu7	361	251	hepatocyte	hepatocyte	NOUN
cord-011435-x73foqu7	361	252	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	361	253	in	in	ADP
cord-011435-x73foqu7	361	254	early	early	ADJ
cord-011435-x73foqu7	361	255	alcoholic	alcoholic	ADJ
cord-011435-x73foqu7	361	256	liver	liver	NOUN
cord-011435-x73foqu7	361	257	disease	disease	NOUN
cord-011435-x73foqu7	361	258	the	the	DET
cord-011435-x73foqu7	361	259	non	non	ADJ
cord-011435-x73foqu7	361	260	-	-	ADJ
cord-011435-x73foqu7	361	261	transcriptional	transcriptional	ADJ
cord-011435-x73foqu7	361	262	activity	activity	NOUN
cord-011435-x73foqu7	361	263	of	of	ADP
cord-011435-x73foqu7	361	264	irf3	irf3	PROPN
cord-011435-x73foqu7	361	265	modulates	modulate	VERB
cord-011435-x73foqu7	361	266	hepatic	hepatic	ADJ
cord-011435-x73foqu7	361	267	immune	immune	ADJ
cord-011435-x73foqu7	361	268	cell	cell	NOUN
cord-011435-x73foqu7	361	269	populations	population	NOUN
cord-011435-x73foqu7	361	270	in	in	ADP
cord-011435-x73foqu7	361	271	acute	acute	NOUN
cord-011435-x73foqu7	361	272	on	on	ADP
cord-011435-x73foqu7	361	273	chronic	chronic	ADJ
cord-011435-x73foqu7	361	274	ethanol	ethanol	NOUN
cord-011435-x73foqu7	361	275	administration	administration	NOUN
cord-011435-x73foqu7	361	276	in	in	ADP
cord-011435-x73foqu7	361	277	mice	mouse	NOUN
cord-011435-x73foqu7	361	278	nontranscriptional	nontranscriptional	ADJ
cord-011435-x73foqu7	361	279	activity	activity	NOUN
cord-011435-x73foqu7	361	280	of	of	ADP
cord-011435-x73foqu7	361	281	interferon	interferon	ADJ
cord-011435-x73foqu7	361	282	regulatory	regulatory	ADJ
cord-011435-x73foqu7	361	283	factor	factor	NOUN
cord-011435-x73foqu7	361	284	3	3	NUM
cord-011435-x73foqu7	361	285	protects	protect	VERB
cord-011435-x73foqu7	361	286	mice	mouse	NOUN
cord-011435-x73foqu7	361	287	from	from	ADP
cord-011435-x73foqu7	361	288	high	high	ADJ
cord-011435-x73foqu7	361	289	-	-	PUNCT
cord-011435-x73foqu7	361	290	fat	fat	NOUN
cord-011435-x73foqu7	361	291	diet	diet	NOUN
cord-011435-x73foqu7	361	292	-	-	PUNCT
cord-011435-x73foqu7	361	293	induced	induce	VERB
cord-011435-x73foqu7	361	294	liver	liver	NOUN
cord-011435-x73foqu7	361	295	injury	injury	NOUN
cord-011435-x73foqu7	361	296	sting	sting	NOUN
cord-011435-x73foqu7	361	297	requires	require	VERB
cord-011435-x73foqu7	361	298	the	the	DET
cord-011435-x73foqu7	361	299	adaptor	adaptor	NOUN
cord-011435-x73foqu7	361	300	trif	trif	NOUN
cord-011435-x73foqu7	361	301	to	to	PART
cord-011435-x73foqu7	361	302	trigger	trigger	VERB
cord-011435-x73foqu7	361	303	innate	innate	ADJ
cord-011435-x73foqu7	361	304	immune	immune	ADJ
cord-011435-x73foqu7	361	305	responses	response	NOUN
cord-011435-x73foqu7	361	306	to	to	ADP
cord-011435-x73foqu7	361	307	microbial	microbial	ADJ
cord-011435-x73foqu7	361	308	infection	infection	NOUN
cord-011435-x73foqu7	361	309	the	the	DET
cord-011435-x73foqu7	361	310	interaction	interaction	NOUN
cord-011435-x73foqu7	361	311	of	of	ADP
cord-011435-x73foqu7	361	312	antibody	antibody	NOUN
cord-011435-x73foqu7	361	313	with	with	ADP
cord-011435-x73foqu7	361	314	the	the	DET
cord-011435-x73foqu7	361	315	major	major	ADJ
cord-011435-x73foqu7	361	316	surface	surface	NOUN
cord-011435-x73foqu7	361	317	glycoprotein	glycoprotein	NOUN
cord-011435-x73foqu7	361	318	of	of	ADP
cord-011435-x73foqu7	361	319	vesicular	vesicular	ADJ
cord-011435-x73foqu7	361	320	stomatitis	stomatitis	PROPN
cord-011435-x73foqu7	361	321	virus	virus	NOUN
cord-011435-x73foqu7	361	322	.	.	PUNCT
cord-011435-x73foqu7	362	1	i.	i.	PROPN
cord-011435-x73foqu7	362	2	analysis	analysis	PROPN
cord-011435-x73foqu7	362	3	of	of	ADP
cord-011435-x73foqu7	362	4	neutralizing	neutralize	VERB
cord-011435-x73foqu7	362	5	epitopes	epitope	NOUN
cord-011435-x73foqu7	362	6	with	with	ADP
cord-011435-x73foqu7	362	7	monoclonal	monoclonal	NOUN
cord-011435-x73foqu7	362	8	antibodies	antibody	NOUN
cord-011435-x73foqu7	362	9	antigenic	antigenic	ADJ
cord-011435-x73foqu7	362	10	diversification	diversification	NOUN
cord-011435-x73foqu7	362	11	is	be	AUX
cord-011435-x73foqu7	362	12	correlated	correlate	VERB
cord-011435-x73foqu7	362	13	with	with	ADP
cord-011435-x73foqu7	362	14	increased	increase	VERB
cord-011435-x73foqu7	362	15	thermostability	thermostability	NOUN
cord-011435-x73foqu7	362	16	in	in	ADP
cord-011435-x73foqu7	362	17	a	a	DET
cord-011435-x73foqu7	362	18	mammalian	mammalian	ADJ
cord-011435-x73foqu7	362	19	virus	virus	NOUN
cord-011435-x73foqu7	362	20	traf6	traf6	PROPN
cord-011435-x73foqu7	362	21	plays	play	VERB
cord-011435-x73foqu7	362	22	a	a	DET
cord-011435-x73foqu7	362	23	proviral	proviral	ADJ
cord-011435-x73foqu7	362	24	role	role	NOUN
cord-011435-x73foqu7	362	25	in	in	ADP
cord-011435-x73foqu7	362	26	tick	tick	NOUN
cord-011435-x73foqu7	362	27	-	-	PUNCT
cord-011435-x73foqu7	362	28	borne	bear	VERB
cord-011435-x73foqu7	362	29	flavivirus	flavivirus	NOUN
cord-011435-x73foqu7	362	30	infection	infection	NOUN
cord-011435-x73foqu7	362	31	through	through	ADP
cord-011435-x73foqu7	362	32	interaction	interaction	NOUN
cord-011435-x73foqu7	362	33	with	with	ADP
cord-011435-x73foqu7	362	34	the	the	DET
cord-011435-x73foqu7	362	35	ns3	ns3	ADJ
cord-011435-x73foqu7	362	36	protease	protease	NOUN
cord-011435-x73foqu7	362	37	inhibition	inhibition	NOUN
cord-011435-x73foqu7	362	38	of	of	ADP
cord-011435-x73foqu7	362	39	human	human	ADJ
cord-011435-x73foqu7	362	40	parainfluenza	parainfluenza	NOUN
cord-011435-x73foqu7	362	41	virus	virus	NOUN
cord-011435-x73foqu7	362	42	type	type	NOUN
cord-011435-x73foqu7	362	43	3	3	NUM
cord-011435-x73foqu7	362	44	infection	infection	NOUN
cord-011435-x73foqu7	362	45	by	by	ADP
cord-011435-x73foqu7	362	46	novel	novel	ADJ
cord-011435-x73foqu7	362	47	small	small	ADJ
cord-011435-x73foqu7	362	48	molecules	molecule	NOUN
cord-011435-x73foqu7	362	49	herpes	herpe	NOUN
cord-011435-x73foqu7	362	50	simplex	simplex	ADJ
cord-011435-x73foqu7	362	51	virus	virus	NOUN
cord-011435-x73foqu7	362	52	type	type	NOUN
cord-011435-x73foqu7	362	53	1	1	NUM
cord-011435-x73foqu7	362	54	neuronal	neuronal	ADJ
cord-011435-x73foqu7	362	55	infection	infection	NOUN
cord-011435-x73foqu7	362	56	perturbs	perturb	NOUN
cord-011435-x73foqu7	362	57	golgi	golgi	PROPN
cord-011435-x73foqu7	362	58	apparatus	apparatus	PROPN
cord-011435-x73foqu7	362	59	integrity	integrity	PROPN
cord-011435-x73foqu7	362	60	through	through	ADP
cord-011435-x73foqu7	362	61	activation	activation	NOUN
cord-011435-x73foqu7	362	62	of	of	ADP
cord-011435-x73foqu7	362	63	src	src	NOUN
cord-011435-x73foqu7	362	64	tyrosine	tyrosine	NOUN
cord-011435-x73foqu7	362	65	kinase	kinase	NOUN
cord-011435-x73foqu7	362	66	and	and	CCONJ
cord-011435-x73foqu7	362	67	dyn-2	dyn-2	PUNCT
cord-011435-x73foqu7	362	68	gtpase	gtpase	NOUN
cord-011435-x73foqu7	362	69	a	a	DET
cord-011435-x73foqu7	362	70	new	new	ADJ
cord-011435-x73foqu7	362	71	mechanism	mechanism	NOUN
cord-011435-x73foqu7	362	72	of	of	ADP
cord-011435-x73foqu7	362	73	interferon	interferon	PROPN
cord-011435-x73foqu7	362	74	's	's	PART
cord-011435-x73foqu7	362	75	antiviral	antiviral	ADJ
cord-011435-x73foqu7	362	76	action	action	NOUN
cord-011435-x73foqu7	362	77	:	:	PUNCT
cord-011435-x73foqu7	362	78	induction	induction	NOUN
cord-011435-x73foqu7	362	79	of	of	ADP
cord-011435-x73foqu7	362	80	autophagy	autophagy	PROPN
cord-011435-x73foqu7	362	81	,	,	PUNCT
cord-011435-x73foqu7	362	82	essential	essential	ADJ
cord-011435-x73foqu7	362	83	for	for	ADP
cord-011435-x73foqu7	362	84	paramyxovirus	paramyxovirus	NOUN
cord-011435-x73foqu7	362	85	replication	replication	NOUN
cord-011435-x73foqu7	362	86	,	,	PUNCT
cord-011435-x73foqu7	362	87	is	be	AUX
cord-011435-x73foqu7	362	88	inhibited	inhibit	VERB
cord-011435-x73foqu7	362	89	by	by	ADP
cord-011435-x73foqu7	362	90	the	the	DET
cord-011435-x73foqu7	362	91	interferon	interferon	NOUN
cord-011435-x73foqu7	362	92	stimulated	stimulate	VERB
cord-011435-x73foqu7	362	93	gene	gene	NOUN
cord-011435-x73foqu7	362	94	discovery	discovery	NOUN
cord-011435-x73foqu7	362	95	of	of	ADP
cord-011435-x73foqu7	362	96	novel	novel	ADJ
cord-011435-x73foqu7	362	97	immunostimulants	immunostimulant	NOUN
cord-011435-x73foqu7	362	98	by	by	ADP
cord-011435-x73foqu7	362	99	dendritic	dendritic	ADJ
cord-011435-x73foqu7	362	100	-	-	PUNCT
cord-011435-x73foqu7	362	101	cell	cell	NOUN
cord-011435-x73foqu7	362	102	-	-	PUNCT
cord-011435-x73foqu7	362	103	based	base	VERB
cord-011435-x73foqu7	362	104	functional	functional	ADJ
cord-011435-x73foqu7	362	105	screening	screening	NOUN
cord-011435-x73foqu7	362	106	activation	activation	NOUN
cord-011435-x73foqu7	362	107	of	of	ADP
cord-011435-x73foqu7	362	108	interferon	interferon	ADJ
cord-011435-x73foqu7	362	109	regulatory	regulatory	ADJ
cord-011435-x73foqu7	362	110	factor	factor	NOUN
cord-011435-x73foqu7	362	111	3	3	NUM
cord-011435-x73foqu7	362	112	in	in	ADP
cord-011435-x73foqu7	362	113	response	response	NOUN
cord-011435-x73foqu7	362	114	to	to	ADP
cord-011435-x73foqu7	362	115	dna	dna	NOUN
cord-011435-x73foqu7	362	116	-	-	PUNCT
cord-011435-x73foqu7	362	117	damaging	damaging	ADJ
cord-011435-x73foqu7	362	118	agents	agent	NOUN
cord-011435-x73foqu7	362	119	adriamycin	adriamycin	PROPN
cord-011435-x73foqu7	362	120	-	-	PUNCT
cord-011435-x73foqu7	362	121	induced	induce	VERB
cord-011435-x73foqu7	362	122	dna	dna	PROPN
cord-011435-x73foqu7	362	123	damage	damage	NOUN
cord-011435-x73foqu7	362	124	mediated	mediate	VERB
cord-011435-x73foqu7	362	125	by	by	ADP
cord-011435-x73foqu7	362	126	mammalian	mammalian	ADJ
cord-011435-x73foqu7	362	127	dna	dna	PROPN
cord-011435-x73foqu7	362	128	topoisomerase	topoisomerase	PROPN
cord-011435-x73foqu7	362	129	ii	ii	PROPN
cord-011435-x73foqu7	362	130	identification	identification	NOUN
cord-011435-x73foqu7	362	131	of	of	ADP
cord-011435-x73foqu7	362	132	the	the	DET
cord-011435-x73foqu7	362	133	molecular	molecular	ADJ
cord-011435-x73foqu7	362	134	basis	basis	NOUN
cord-011435-x73foqu7	362	135	of	of	ADP
cord-011435-x73foqu7	362	136	doxorubicin	doxorubicin	NOUN
cord-011435-x73foqu7	362	137	-	-	PUNCT
cord-011435-x73foqu7	362	138	induced	induce	VERB
cord-011435-x73foqu7	362	139	cardiotoxicity	cardiotoxicity	NOUN
cord-011435-x73foqu7	362	140	down	down	ADP
cord-011435-x73foqu7	362	141	-	-	PUNCT
cord-011435-x73foqu7	362	142	regulation	regulation	NOUN
cord-011435-x73foqu7	362	143	of	of	ADP
cord-011435-x73foqu7	362	144	p53	p53	NOUN
cord-011435-x73foqu7	362	145	by	by	ADP
cord-011435-x73foqu7	362	146	double	double	ADV
cord-011435-x73foqu7	362	147	-	-	PUNCT
cord-011435-x73foqu7	362	148	stranded	strand	VERB
cord-011435-x73foqu7	362	149	rna	rna	NOUN
cord-011435-x73foqu7	362	150	modulates	modulate	VERB
cord-011435-x73foqu7	362	151	the	the	DET
cord-011435-x73foqu7	362	152	antiviral	antiviral	ADJ
cord-011435-x73foqu7	362	153	response	response	NOUN
cord-011435-x73foqu7	362	154	roles	role	NOUN
cord-011435-x73foqu7	362	155	of	of	ADP
cord-011435-x73foqu7	362	156	tlr3	tlr3	NOUN
cord-011435-x73foqu7	362	157	and	and	CCONJ
cord-011435-x73foqu7	362	158	rig	rig	NOUN
cord-011435-x73foqu7	362	159	-	-	PUNCT
cord-011435-x73foqu7	362	160	i	i	NOUN
cord-011435-x73foqu7	362	161	in	in	ADP
cord-011435-x73foqu7	362	162	mediating	mediate	VERB
cord-011435-x73foqu7	362	163	the	the	DET
cord-011435-x73foqu7	362	164	inflammatory	inflammatory	ADJ
cord-011435-x73foqu7	362	165	response	response	NOUN
cord-011435-x73foqu7	362	166	in	in	ADP
cord-011435-x73foqu7	362	167	mouse	mouse	PROPN
cord-011435-x73foqu7	362	168	microglia	microglia	PROPN
cord-011435-x73foqu7	362	169	following	follow	VERB
cord-011435-x73foqu7	362	170	japanese	japanese	ADJ
cord-011435-x73foqu7	362	171	encephalitis	encephalitis	NOUN
cord-011435-x73foqu7	362	172	virus	virus	NOUN
cord-011435-x73foqu7	362	173	infection	infection	NOUN
cord-011435-x73foqu7	362	174	activation	activation	NOUN
cord-011435-x73foqu7	362	175	of	of	ADP
cord-011435-x73foqu7	362	176	c	c	PROPN
cord-011435-x73foqu7	362	177	-	-	PUNCT
cord-011435-x73foqu7	362	178	jun	jun	PROPN
cord-011435-x73foqu7	362	179	n	n	ADJ
cord-011435-x73foqu7	362	180	-	-	ADJ
cord-011435-x73foqu7	362	181	terminal	terminal	ADJ
cord-011435-x73foqu7	362	182	kinase	kinase	NOUN
cord-011435-x73foqu7	362	183	upon	upon	SCONJ
cord-011435-x73foqu7	362	184	influenza	influenza	NOUN
cord-011435-x73foqu7	362	185	a	a	DET
cord-011435-x73foqu7	362	186	virus	virus	NOUN
cord-011435-x73foqu7	362	187	(	(	PUNCT
cord-011435-x73foqu7	362	188	iav	iav	PROPN
cord-011435-x73foqu7	362	189	)	)	PUNCT
cord-011435-x73foqu7	362	190	infection	infection	NOUN
cord-011435-x73foqu7	362	191	is	be	AUX
cord-011435-x73foqu7	362	192	independent	independent	ADJ
cord-011435-x73foqu7	362	193	of	of	ADP
cord-011435-x73foqu7	362	194	pathogen	pathogen	PROPN
cord-011435-x73foqu7	362	195	-	-	PUNCT
cord-011435-x73foqu7	362	196	related	relate	VERB
cord-011435-x73foqu7	362	197	receptors	receptor	NOUN
cord-011435-x73foqu7	362	198	but	but	CCONJ
cord-011435-x73foqu7	362	199	dependent	dependent	ADJ
cord-011435-x73foqu7	362	200	on	on	ADP
cord-011435-x73foqu7	362	201	amino	amino	ADJ
cord-011435-x73foqu7	362	202	acid	acid	NOUN
cord-011435-x73foqu7	362	203	sequence	sequence	NOUN
cord-011435-x73foqu7	362	204	variations	variation	NOUN
cord-011435-x73foqu7	362	205	of	of	ADP
cord-011435-x73foqu7	362	206	iav	iav	PROPN
cord-011435-x73foqu7	362	207	ns1	ns1	PROPN
cord-011435-x73foqu7	362	208	early	early	ADJ
cord-011435-x73foqu7	362	209	innate	innate	ADJ
cord-011435-x73foqu7	362	210	recognition	recognition	NOUN
cord-011435-x73foqu7	362	211	of	of	ADP
cord-011435-x73foqu7	362	212	herpes	herpe	NOUN
cord-011435-x73foqu7	362	213	simplex	simplex	ADJ
cord-011435-x73foqu7	362	214	virus	virus	NOUN
cord-011435-x73foqu7	362	215	in	in	ADP
cord-011435-x73foqu7	362	216	human	human	ADJ
cord-011435-x73foqu7	362	217	primary	primary	ADJ
cord-011435-x73foqu7	362	218	macrophages	macrophage	NOUN
cord-011435-x73foqu7	362	219	is	be	AUX
cord-011435-x73foqu7	362	220	mediated	mediate	VERB
cord-011435-x73foqu7	362	221	via	via	ADP
cord-011435-x73foqu7	362	222	the	the	DET
cord-011435-x73foqu7	362	223	mda5	mda5	PROPN
cord-011435-x73foqu7	362	224	/	/	SYM
cord-011435-x73foqu7	362	225	mavs	mavs	PROPN
cord-011435-x73foqu7	362	226	-	-	PUNCT
cord-011435-x73foqu7	362	227	dependent	dependent	ADJ
cord-011435-x73foqu7	362	228	and	and	CCONJ
cord-011435-x73foqu7	362	229	mda5	mda5	PROPN
cord-011435-x73foqu7	362	230	/	/	SYM
cord-011435-x73foqu7	362	231	mavs	mavs	PROPN
cord-011435-x73foqu7	362	232	/	/	SYM
cord-011435-x73foqu7	362	233	rna	rna	PROPN
cord-011435-x73foqu7	362	234	polymerase	polymerase	PROPN
cord-011435-x73foqu7	362	235	iii	iii	ADJ
cord-011435-x73foqu7	362	236	-	-	PUNCT
cord-011435-x73foqu7	362	237	independent	independent	ADJ
cord-011435-x73foqu7	362	238	pathways	pathway	NOUN
cord-011435-x73foqu7	362	239	establishment	establishment	NOUN
cord-011435-x73foqu7	362	240	and	and	CCONJ
cord-011435-x73foqu7	362	241	maintenance	maintenance	NOUN
cord-011435-x73foqu7	362	242	of	of	ADP
cord-011435-x73foqu7	362	243	the	the	DET
cord-011435-x73foqu7	362	244	innate	innate	ADJ
cord-011435-x73foqu7	362	245	antiviral	antiviral	ADJ
cord-011435-x73foqu7	362	246	response	response	NOUN
cord-011435-x73foqu7	362	247	to	to	ADP
cord-011435-x73foqu7	362	248	west	west	PROPN
cord-011435-x73foqu7	362	249	nile	nile	PROPN
cord-011435-x73foqu7	362	250	virus	virus	PROPN
cord-011435-x73foqu7	362	251	involves	involve	VERB
cord-011435-x73foqu7	362	252	both	both	PRON
cord-011435-x73foqu7	362	253	rig	rig	NOUN
cord-011435-x73foqu7	362	254	-	-	PUNCT
cord-011435-x73foqu7	362	255	i	i	NOUN
cord-011435-x73foqu7	362	256	and	and	CCONJ
cord-011435-x73foqu7	362	257	mda5	mda5	PROPN
cord-011435-x73foqu7	362	258	signaling	signal	VERB
cord-011435-x73foqu7	362	259	through	through	ADP
cord-011435-x73foqu7	362	260	ips-1	ips-1	PUNCT
cord-011435-x73foqu7	362	261	rig	rig	NOUN
cord-011435-x73foqu7	362	262	-	-	PUNCT
cord-011435-x73foqu7	362	263	i	i	PRON
cord-011435-x73foqu7	362	264	recognizes	recognize	VERB
cord-011435-x73foqu7	362	265	the	the	DET
cord-011435-x73foqu7	362	266	5	5	NUM
cord-011435-x73foqu7	362	267	region	region	NOUN
cord-011435-x73foqu7	362	268	of	of	ADP
cord-011435-x73foqu7	362	269	dengue	dengue	PROPN
cord-011435-x73foqu7	362	270	and	and	CCONJ
cord-011435-x73foqu7	362	271	zika	zika	PROPN
cord-011435-x73foqu7	362	272	virus	virus	PROPN
cord-011435-x73foqu7	362	273	genomes	genome	VERB
cord-011435-x73foqu7	362	274	interferons	interferon	NOUN
cord-011435-x73foqu7	362	275	and	and	CCONJ
cord-011435-x73foqu7	362	276	viral	viral	ADJ
cord-011435-x73foqu7	362	277	infections	infection	NOUN
cord-011435-x73foqu7	362	278	triggering	trigger	VERB
cord-011435-x73foqu7	362	279	the	the	DET
cord-011435-x73foqu7	362	280	innate	innate	ADJ
cord-011435-x73foqu7	362	281	antiviral	antiviral	ADJ
cord-011435-x73foqu7	362	282	response	response	NOUN
cord-011435-x73foqu7	362	283	through	through	ADP
cord-011435-x73foqu7	362	284	irf-3	irf-3	PUNCT
cord-011435-x73foqu7	362	285	activation	activation	NOUN
cord-011435-x73foqu7	362	286	high	high	ADJ
cord-011435-x73foqu7	362	287	-	-	PUNCT
cord-011435-x73foqu7	362	288	throughput	throughput	NOUN
cord-011435-x73foqu7	362	289	screening	screening	NOUN
cord-011435-x73foqu7	362	290	for	for	ADP
cord-011435-x73foqu7	362	291	tlr3	tlr3	NOUN
cord-011435-x73foqu7	362	292	-	-	PUNCT
cord-011435-x73foqu7	362	293	ifn	ifn	NOUN
cord-011435-x73foqu7	362	294	regulatory	regulatory	ADJ
cord-011435-x73foqu7	362	295	factor	factor	NOUN
cord-011435-x73foqu7	362	296	3	3	NUM
cord-011435-x73foqu7	362	297	signaling	signal	VERB
cord-011435-x73foqu7	362	298	pathway	pathway	NOUN
cord-011435-x73foqu7	362	299	modulators	modulator	NOUN
cord-011435-x73foqu7	362	300	identifies	identify	VERB
cord-011435-x73foqu7	362	301	several	several	ADJ
cord-011435-x73foqu7	362	302	antipsychotic	antipsychotic	ADJ
cord-011435-x73foqu7	362	303	drugs	drug	NOUN
cord-011435-x73foqu7	362	304	as	as	SCONJ
cord-011435-x73foqu7	362	305	tlr	tlr	ADJ
cord-011435-x73foqu7	362	306	inhibitors	inhibitor	NOUN
cord-011435-x73foqu7	362	307	emerging	emerge	VERB
cord-011435-x73foqu7	362	308	alphaviruses	alphavirus	NOUN
cord-011435-x73foqu7	362	309	are	be	AUX
cord-011435-x73foqu7	362	310	sensitive	sensitive	ADJ
cord-011435-x73foqu7	362	311	to	to	ADP
cord-011435-x73foqu7	362	312	cellular	cellular	ADJ
cord-011435-x73foqu7	362	313	states	state	NOUN
cord-011435-x73foqu7	362	314	induced	induce	VERB
cord-011435-x73foqu7	362	315	by	by	ADP
cord-011435-x73foqu7	362	316	a	a	DET
cord-011435-x73foqu7	362	317	novel	novel	ADJ
cord-011435-x73foqu7	362	318	small	small	ADJ
cord-011435-x73foqu7	362	319	-	-	PUNCT
cord-011435-x73foqu7	362	320	molecule	molecule	NOUN
cord-011435-x73foqu7	362	321	agonist	agonist	NOUN
cord-011435-x73foqu7	362	322	of	of	ADP
cord-011435-x73foqu7	362	323	the	the	DET
cord-011435-x73foqu7	362	324	sting	sting	ADJ
cord-011435-x73foqu7	362	325	pathway	pathway	NOUN
cord-011435-x73foqu7	362	326	identification	identification	NOUN
cord-011435-x73foqu7	362	327	of	of	ADP
cord-011435-x73foqu7	362	328	novel	novel	ADJ
cord-011435-x73foqu7	362	329	inhibitors	inhibitor	NOUN
cord-011435-x73foqu7	362	330	of	of	ADP
cord-011435-x73foqu7	362	331	the	the	DET
cord-011435-x73foqu7	362	332	type	type	NOUN
cord-011435-x73foqu7	362	333	i	i	PRON
cord-011435-x73foqu7	362	334	interferon	interferon	VERB
cord-011435-x73foqu7	362	335	induction	induction	NOUN
cord-011435-x73foqu7	362	336	pathway	pathway	NOUN
cord-011435-x73foqu7	362	337	using	use	VERB
cord-011435-x73foqu7	362	338	cell	cell	NOUN
cord-011435-x73foqu7	362	339	-	-	PUNCT
cord-011435-x73foqu7	362	340	based	base	VERB
cord-011435-x73foqu7	362	341	high	high	ADJ
cord-011435-x73foqu7	362	342	-	-	PUNCT
cord-011435-x73foqu7	362	343	throughput	throughput	NOUN
cord-011435-x73foqu7	362	344	screening	screen	VERB
cord-011435-x73foqu7	362	345	a	a	DET
cord-011435-x73foqu7	362	346	small	small	ADJ
cord-011435-x73foqu7	362	347	-	-	PUNCT
cord-011435-x73foqu7	362	348	molecule	molecule	NOUN
cord-011435-x73foqu7	362	349	irf3	irf3	PROPN
cord-011435-x73foqu7	362	350	agonist	agonist	NOUN
cord-011435-x73foqu7	362	351	functions	function	NOUN
cord-011435-x73foqu7	362	352	as	as	ADP
cord-011435-x73foqu7	362	353	an	an	DET
cord-011435-x73foqu7	362	354	influenza	influenza	NOUN
cord-011435-x73foqu7	362	355	vaccine	vaccine	NOUN
cord-011435-x73foqu7	362	356	adjuvant	adjuvant	ADJ
cord-011435-x73foqu7	362	357	by	by	ADP
cord-011435-x73foqu7	362	358	modulating	modulate	VERB
cord-011435-x73foqu7	362	359	the	the	DET
cord-011435-x73foqu7	362	360	antiviral	antiviral	ADJ
cord-011435-x73foqu7	362	361	immune	immune	ADJ
cord-011435-x73foqu7	362	362	response	response	NOUN
cord-011435-x73foqu7	362	363	drug	drug	NOUN
cord-011435-x73foqu7	362	364	-	-	PUNCT
cord-011435-x73foqu7	362	365	induced	induce	VERB
cord-011435-x73foqu7	362	366	histone	histone	NOUN
cord-011435-x73foqu7	362	367	eviction	eviction	NOUN
cord-011435-x73foqu7	362	368	from	from	ADP
cord-011435-x73foqu7	362	369	open	open	ADJ
cord-011435-x73foqu7	362	370	chromatin	chromatin	NOUN
cord-011435-x73foqu7	362	371	contributes	contribute	VERB
cord-011435-x73foqu7	362	372	to	to	ADP
cord-011435-x73foqu7	362	373	the	the	DET
cord-011435-x73foqu7	362	374	chemotherapeutic	chemotherapeutic	NOUN
cord-011435-x73foqu7	362	375	effects	effect	NOUN
cord-011435-x73foqu7	362	376	of	of	ADP
cord-011435-x73foqu7	362	377	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	362	378	recent	recent	ADJ
cord-011435-x73foqu7	362	379	advances	advance	NOUN
cord-011435-x73foqu7	362	380	in	in	ADP
cord-011435-x73foqu7	362	381	understanding	understand	VERB
cord-011435-x73foqu7	362	382	viral	viral	ADJ
cord-011435-x73foqu7	362	383	evasion	evasion	NOUN
cord-011435-x73foqu7	362	384	of	of	ADP
cord-011435-x73foqu7	362	385	type	type	NOUN
cord-011435-x73foqu7	362	386	i	i	PRON
cord-011435-x73foqu7	362	387	interferon	interferon	PROPN
cord-011435-x73foqu7	362	388	topoisomerase	topoisomerase	PROPN
cord-011435-x73foqu7	362	389	ii	ii	PROPN
cord-011435-x73foqu7	362	390	inhibitors	inhibitor	NOUN
cord-011435-x73foqu7	362	391	induce	induce	VERB
cord-011435-x73foqu7	362	392	dna	dna	PROPN
cord-011435-x73foqu7	362	393	damage	damage	NOUN
cord-011435-x73foqu7	362	394	-	-	PUNCT
cord-011435-x73foqu7	362	395	dependent	dependent	ADJ
cord-011435-x73foqu7	362	396	interferon	interferon	NOUN
cord-011435-x73foqu7	362	397	responses	response	NOUN
cord-011435-x73foqu7	362	398	circumventing	circumvent	VERB
cord-011435-x73foqu7	362	399	ebola	ebola	PROPN
cord-011435-x73foqu7	362	400	virus	virus	NOUN
cord-011435-x73foqu7	362	401	immune	immune	ADJ
cord-011435-x73foqu7	362	402	evasion	evasion	NOUN
cord-011435-x73foqu7	362	403	topoisomerase	topoisomerase	NOUN
cord-011435-x73foqu7	362	404	1	1	NUM
cord-011435-x73foqu7	362	405	inhibition	inhibition	NOUN
cord-011435-x73foqu7	362	406	promotes	promote	VERB
cord-011435-x73foqu7	362	407	cyclic	cyclic	ADJ
cord-011435-x73foqu7	362	408	gmp	gmp	ADJ
cord-011435-x73foqu7	362	409	-	-	PUNCT
cord-011435-x73foqu7	362	410	amp	amp	ADJ
cord-011435-x73foqu7	362	411	synthase	synthase	NOUN
cord-011435-x73foqu7	362	412	-	-	PUNCT
cord-011435-x73foqu7	362	413	dependent	dependent	ADJ
cord-011435-x73foqu7	362	414	antiviral	antiviral	ADJ
cord-011435-x73foqu7	362	415	responses	response	NOUN
cord-011435-x73foqu7	362	416	the	the	DET
cord-011435-x73foqu7	362	417	cytoplasmic	cytoplasmic	ADJ
cord-011435-x73foqu7	362	418	dna	dna	NOUN
cord-011435-x73foqu7	362	419	sensor	sensor	NOUN
cord-011435-x73foqu7	362	420	cgas	cgas	NOUN
cord-011435-x73foqu7	362	421	promotes	promote	VERB
cord-011435-x73foqu7	362	422	mitotic	mitotic	ADJ
cord-011435-x73foqu7	362	423	cell	cell	NOUN
cord-011435-x73foqu7	362	424	death	death	PROPN
cord-011435-x73foqu7	362	425	erk	erk	PROPN
cord-011435-x73foqu7	362	426	-	-	PUNCT
cord-011435-x73foqu7	362	427	mediated	mediate	VERB
cord-011435-x73foqu7	362	428	autophagy	autophagy	NOUN
cord-011435-x73foqu7	362	429	promotes	promote	VERB
cord-011435-x73foqu7	362	430	inactivated	inactivated	ADJ
cord-011435-x73foqu7	362	431	sendai	sendai	PROPN
cord-011435-x73foqu7	362	432	virus	virus	PROPN
cord-011435-x73foqu7	362	433	(	(	PUNCT
cord-011435-x73foqu7	362	434	hvj	hvj	PROPN
cord-011435-x73foqu7	362	435	-	-	PUNCT
cord-011435-x73foqu7	362	436	e)-induced	e)-induce	VERB
cord-011435-x73foqu7	362	437	apoptosis	apoptosis	NOUN
cord-011435-x73foqu7	362	438	in	in	ADP
cord-011435-x73foqu7	362	439	hela	hela	PROPN
cord-011435-x73foqu7	362	440	cells	cell	NOUN
cord-011435-x73foqu7	362	441	in	in	ADP
cord-011435-x73foqu7	362	442	an	an	DET
cord-011435-x73foqu7	362	443	atg3	atg3	PROPN
cord-011435-x73foqu7	362	444	-	-	PUNCT
cord-011435-x73foqu7	362	445	dependent	dependent	ADJ
cord-011435-x73foqu7	362	446	manner	manner	NOUN
cord-011435-x73foqu7	362	447	disruption	disruption	NOUN
cord-011435-x73foqu7	362	448	of	of	ADP
cord-011435-x73foqu7	362	449	erk	erk	ADJ
cord-011435-x73foqu7	362	450	-	-	PUNCT
cord-011435-x73foqu7	362	451	dependent	dependent	ADJ
cord-011435-x73foqu7	362	452	type	type	NOUN
cord-011435-x73foqu7	362	453	i	i	PRON
cord-011435-x73foqu7	362	454	interferon	interferon	ADJ
cord-011435-x73foqu7	362	455	induction	induction	NOUN
cord-011435-x73foqu7	362	456	breaks	break	VERB
cord-011435-x73foqu7	362	457	the	the	DET
cord-011435-x73foqu7	362	458	myxoma	myxoma	PROPN
cord-011435-x73foqu7	362	459	virus	virus	NOUN
cord-011435-x73foqu7	362	460	species	specie	NOUN
cord-011435-x73foqu7	362	461	barrier	barrier	NOUN
cord-011435-x73foqu7	362	462	a	a	DET
cord-011435-x73foqu7	362	463	derivate	derivate	NOUN
cord-011435-x73foqu7	362	464	of	of	ADP
cord-011435-x73foqu7	362	465	the	the	DET
cord-011435-x73foqu7	362	466	antibiotic	antibiotic	ADJ
cord-011435-x73foqu7	362	467	doxorubicin	doxorubicin	PROPN
cord-011435-x73foqu7	362	468	is	be	AUX
cord-011435-x73foqu7	362	469	a	a	DET
cord-011435-x73foqu7	362	470	selective	selective	ADJ
cord-011435-x73foqu7	362	471	inhibitor	inhibitor	NOUN
cord-011435-x73foqu7	362	472	of	of	ADP
cord-011435-x73foqu7	362	473	dengue	dengue	PROPN
cord-011435-x73foqu7	362	474	and	and	CCONJ
cord-011435-x73foqu7	362	475	yellow	yellow	ADJ
cord-011435-x73foqu7	362	476	fever	fever	NOUN
cord-011435-x73foqu7	362	477	virus	virus	NOUN
cord-011435-x73foqu7	362	478	replication	replication	NOUN
cord-011435-x73foqu7	362	479	in	in	X
cord-011435-x73foqu7	362	480	vitro	vitro	X
cord-011435-x73foqu7	362	481	inhibition	inhibition	NOUN
cord-011435-x73foqu7	362	482	of	of	ADP
cord-011435-x73foqu7	362	483	herpes	herpe	NOUN
cord-011435-x73foqu7	362	484	simplex	simplex	ADJ
cord-011435-x73foqu7	362	485	virus	virus	NOUN
cord-011435-x73foqu7	362	486	replication	replication	NOUN
cord-011435-x73foqu7	362	487	by	by	ADP
cord-011435-x73foqu7	362	488	anthracycline	anthracycline	PROPN
cord-011435-x73foqu7	362	489	compounds	compound	VERB
cord-011435-x73foqu7	362	490	high	high	ADJ
cord-011435-x73foqu7	362	491	-	-	PUNCT
cord-011435-x73foqu7	362	492	throughput	throughput	NOUN
cord-011435-x73foqu7	362	493	screening	screening	NOUN
cord-011435-x73foqu7	362	494	and	and	CCONJ
cord-011435-x73foqu7	362	495	identification	identification	NOUN
cord-011435-x73foqu7	362	496	of	of	ADP
cord-011435-x73foqu7	362	497	potent	potent	ADJ
cord-011435-x73foqu7	362	498	broad	broad	ADJ
cord-011435-x73foqu7	362	499	-	-	PUNCT
cord-011435-x73foqu7	362	500	spectrum	spectrum	NOUN
cord-011435-x73foqu7	362	501	inhibitors	inhibitor	NOUN
cord-011435-x73foqu7	362	502	of	of	ADP
cord-011435-x73foqu7	362	503	coronaviruses	coronaviruse	NOUN
cord-011435-x73foqu7	362	504	this	this	DET
cord-011435-x73foqu7	362	505	article	article	NOUN
cord-011435-x73foqu7	362	506	is	be	AUX
cord-011435-x73foqu7	362	507	an	an	DET
cord-011435-x73foqu7	362	508	open	open	ADJ
cord-011435-x73foqu7	362	509	access	access	NOUN
cord-011435-x73foqu7	362	510	article	article	NOUN
cord-011435-x73foqu7	362	511	distributed	distribute	VERB
cord-011435-x73foqu7	362	512	under	under	ADP
cord-011435-x73foqu7	362	513	the	the	DET
cord-011435-x73foqu7	362	514	terms	term	NOUN
cord-011435-x73foqu7	362	515	and	and	CCONJ
cord-011435-x73foqu7	362	516	conditions	condition	NOUN
cord-011435-x73foqu7	362	517	of	of	ADP
cord-011435-x73foqu7	362	518	the	the	DET
cord-011435-x73foqu7	362	519	creative	creative	ADJ
cord-011435-x73foqu7	362	520	commons	commons	ADJ
cord-011435-x73foqu7	362	521	attribution	attribution	NOUN
cord-011435-x73foqu7	362	522	(	(	PUNCT
cord-011435-x73foqu7	362	523	cc	cc	X
cord-011435-x73foqu7	362	524	by	by	ADP
cord-011435-x73foqu7	362	525	)	)	PUNCT
cord-011435-x73foqu7	362	526	license	license	VERB
cord-011435-x73foqu7	362	527	the	the	DET
cord-011435-x73foqu7	362	528	authors	author	NOUN
cord-011435-x73foqu7	362	529	would	would	AUX
cord-011435-x73foqu7	362	530	like	like	VERB
cord-011435-x73foqu7	362	531	to	to	PART
cord-011435-x73foqu7	362	532	thank	thank	VERB
cord-011435-x73foqu7	362	533	ganes	ganes	PROPN
cord-011435-x73foqu7	362	534	sen	sen	PROPN
cord-011435-x73foqu7	362	535	,	,	PUNCT
cord-011435-x73foqu7	362	536	eain	eain	PROPN
cord-011435-x73foqu7	362	537	murphy	murphy	PROPN
cord-011435-x73foqu7	362	538	,	,	PUNCT
cord-011435-x73foqu7	362	539	kevin	kevin	PROPN
cord-011435-x73foqu7	362	540	pan	pan	PROPN
cord-011435-x73foqu7	362	541	,	,	PUNCT
cord-011435-x73foqu7	362	542	jyl	jyl	PROPN
cord-011435-x73foqu7	362	543	matson	matson	PROPN
cord-011435-x73foqu7	362	544	and	and	CCONJ
cord-011435-x73foqu7	362	545	amit	amit	NOUN
cord-011435-x73foqu7	362	546	tiwari	tiwari	NOUN
cord-011435-x73foqu7	362	547	for	for	ADP
cord-011435-x73foqu7	362	548	help	help	NOUN
cord-011435-x73foqu7	362	549	with	with	ADP
cord-011435-x73foqu7	362	550	critical	critical	ADJ
cord-011435-x73foqu7	362	551	reagents	reagent	NOUN
cord-011435-x73foqu7	362	552	and	and	CCONJ
cord-011435-x73foqu7	362	553	resources	resource	NOUN
cord-011435-x73foqu7	362	554	used	use	VERB
cord-011435-x73foqu7	362	555	for	for	ADP
cord-011435-x73foqu7	362	556	the	the	DET
cord-011435-x73foqu7	362	557	study	study	NOUN
cord-011435-x73foqu7	362	558	.	.	PUNCT
cord-011435-x73foqu7	363	1	the	the	DET
cord-011435-x73foqu7	363	2	authors	author	NOUN
cord-011435-x73foqu7	363	3	would	would	AUX
cord-011435-x73foqu7	363	4	like	like	VERB
cord-011435-x73foqu7	363	5	to	to	PART
cord-011435-x73foqu7	363	6	acknowledge	acknowledge	VERB
cord-011435-x73foqu7	363	7	funding	funding	NOUN
cord-011435-x73foqu7	363	8	from	from	ADP
cord-011435-x73foqu7	363	9	the	the	DET
cord-011435-x73foqu7	363	10	national	national	ADJ
cord-011435-x73foqu7	363	11	institutes	institutes	PROPN
cord-011435-x73foqu7	363	12	of	of	ADP
cord-011435-x73foqu7	363	13	health	health	NOUN
cord-011435-x73foqu7	363	14	grant	grant	NOUN
cord-011435-x73foqu7	363	15	aa026017	aa026017	PROPN
cord-011435-x73foqu7	363	16	(	(	PUNCT
cord-011435-x73foqu7	363	17	sc	sc	PROPN
cord-011435-x73foqu7	363	18	)	)	PUNCT
cord-011435-x73foqu7	363	19	,	,	PUNCT
cord-011435-x73foqu7	363	20	american	american	PROPN
cord-011435-x73foqu7	363	21	heart	heart	PROPN
cord-011435-x73foqu7	363	22	association	association	PROPN
cord-011435-x73foqu7	363	23	grant	grant	VERB
cord-011435-x73foqu7	363	24	15sdg25090212	15sdg25090212	NUM
cord-011435-x73foqu7	363	25	(	(	PUNCT
cord-011435-x73foqu7	363	26	sc	sc	PROPN
cord-011435-x73foqu7	363	27	)	)	PUNCT
cord-011435-x73foqu7	363	28	,	,	PUNCT
cord-011435-x73foqu7	363	29	medical	medical	ADJ
cord-011435-x73foqu7	363	30	research	research	NOUN
cord-011435-x73foqu7	363	31	society	society	NOUN
cord-011435-x73foqu7	363	32	(	(	PUNCT
cord-011435-x73foqu7	363	33	sc	sc	PROPN
cord-011435-x73foqu7	363	34	)	)	PUNCT
cord-011435-x73foqu7	363	35	,	,	PUNCT
cord-011435-x73foqu7	363	36	and	and	CCONJ
cord-011435-x73foqu7	363	37	the	the	DET
cord-011435-x73foqu7	363	38	university	university	PROPN
cord-011435-x73foqu7	363	39	of	of	ADP
cord-011435-x73foqu7	363	40	toledo	toledo	PROPN
cord-011435-x73foqu7	363	41	college	college	PROPN
cord-011435-x73foqu7	363	42	of	of	ADP
cord-011435-x73foqu7	363	43	medicine	medicine	NOUN
cord-011435-x73foqu7	363	44	and	and	CCONJ
cord-011435-x73foqu7	363	45	life	life	NOUN
cord-011435-x73foqu7	363	46	sciences	sciences	PROPN
cord-011435-x73foqu7	363	47	startup	startup	NOUN
cord-011435-x73foqu7	363	48	funds	fund	NOUN
cord-011435-x73foqu7	363	49	(	(	PUNCT
cord-011435-x73foqu7	363	50	sc	sc	NOUN
cord-011435-x73foqu7	363	51	and	and	CCONJ
cord-011435-x73foqu7	363	52	rtt	rtt	PROPN
cord-011435-x73foqu7	363	53	)	)	PUNCT
cord-011435-x73foqu7	363	54	.	.	PUNCT
cord-011435-x73foqu7	364	1	the	the	DET
cord-011435-x73foqu7	364	2	authors	author	NOUN
cord-011435-x73foqu7	364	3	declare	declare	VERB
cord-011435-x73foqu7	364	4	no	no	DET
cord-011435-x73foqu7	364	5	conflict	conflict	NOUN
cord-011435-x73foqu7	364	6	of	of	ADP
cord-011435-x73foqu7	364	7	interest	interest	NOUN
cord-011435-x73foqu7	364	8	.	.	PUNCT
cord-011435-x73foqu7	365	1	the	the	DET
cord-011435-x73foqu7	365	2	funders	funder	NOUN
cord-011435-x73foqu7	365	3	had	have	VERB
cord-011435-x73foqu7	365	4	no	no	DET
cord-011435-x73foqu7	365	5	role	role	NOUN
cord-011435-x73foqu7	365	6	in	in	ADP
cord-011435-x73foqu7	365	7	the	the	DET
cord-011435-x73foqu7	365	8	design	design	NOUN
cord-011435-x73foqu7	365	9	of	of	ADP
cord-011435-x73foqu7	365	10	the	the	DET
cord-011435-x73foqu7	365	11	study	study	NOUN
cord-011435-x73foqu7	365	12	;	;	PUNCT
cord-011435-x73foqu7	365	13	in	in	ADP
cord-011435-x73foqu7	365	14	the	the	DET
cord-011435-x73foqu7	365	15	collection	collection	NOUN
cord-011435-x73foqu7	365	16	,	,	PUNCT
cord-011435-x73foqu7	365	17	analyses	analysis	NOUN
cord-011435-x73foqu7	365	18	,	,	PUNCT
cord-011435-x73foqu7	365	19	or	or	CCONJ
cord-011435-x73foqu7	365	20	interpretation	interpretation	NOUN
cord-011435-x73foqu7	365	21	of	of	ADP
cord-011435-x73foqu7	365	22	data	datum	NOUN
cord-011435-x73foqu7	365	23	;	;	PUNCT
cord-011435-x73foqu7	365	24	in	in	ADP
cord-011435-x73foqu7	365	25	the	the	DET
cord-011435-x73foqu7	365	26	writing	writing	NOUN
cord-011435-x73foqu7	365	27	of	of	ADP
cord-011435-x73foqu7	365	28	the	the	DET
cord-011435-x73foqu7	365	29	manuscript	manuscript	NOUN
cord-011435-x73foqu7	365	30	,	,	PUNCT
cord-011435-x73foqu7	365	31	or	or	CCONJ
cord-011435-x73foqu7	365	32	in	in	ADP
cord-011435-x73foqu7	365	33	the	the	DET
cord-011435-x73foqu7	365	34	decision	decision	NOUN
cord-011435-x73foqu7	365	35	to	to	PART
cord-011435-x73foqu7	365	36	publish	publish	VERB
cord-011435-x73foqu7	365	37	the	the	DET
cord-011435-x73foqu7	365	38	results.viruses	results.viruse	NOUN
cord-011435-x73foqu7	365	39	2020	2020	NUM
cord-011435-x73foqu7	365	40	,	,	PUNCT
cord-011435-x73foqu7	365	41	12	12	NUM
cord-011435-x73foqu7	365	42	,	,	PUNCT
cord-011435-x73foqu7	365	43	442	442	NUM
