# bib

id: cord-325444-k6s8v9fs
author: Imperiale, Michael J.
title: Zika Virus Focuses the Gain-of-Function Debate
date: 2016-04-06
extension: .txt
mime: text/plain
words: 1494
sentence: 48
flesch: 44
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summary:
  As the great GOF debate lumbers on without resolution, a new infectious threat has suddenly appeared in the form of Zika virus. Zika virus was discovered in a sentinel monkey in 1974 in the Zika forest in Uganda.


id: cord-318771-mk0eyceg
author: Bendezu-Quispe, Guido
date: 2017-12-27
extension: .txt
mime: text/plain
words: 1866
sentence: 84
flesch: 53
cache: cache/cord-318771-mk0eyceg.txt
txt: txt/cord-318771-mk0eyceg.txt
title:
  Utility of massive open online courses (MOOCs) concerning outbreaks of emerging and reemerging diseases

summary:
  Now, that information is included in methods: From 1st May to 31st May 2017, we conducted a manual search on several learning platforms that offer MOOCs, including Coursera, edX, FutureLearn, Udacity, Miríada X, Alison, FUN.MOOC, Canvas Network, and University to find courses about disease outbreaks using the terms included in the list of WHO disease outbreaks from January 1st to December 31st, 2016 (Box 1). Adding MOOC aggregators (such as Class Central) to the search areas could have identified more courses, than those on offer in May 2017.


id: cord-299440-y6o5e2k5
author: Elachola, Habida
title: A crucial time for public health preparedness: Zika virus and the 2016 Olympics, Umrah, and Hajj
date: 2016-02-07
extension: .txt
mime: text/plain
words: 1974
sentence: 69
flesch: 39
cache: cache/cord-299440-y6o5e2k5.txt
txt: txt/cord-299440-y6o5e2k5.txt
summary:
  Although both countries may have robust vector control eff orts, no single approach is adequate to prevent mosquito bites and non-vector modes of Zika virus transmission; a combination of measures is needed at personal, community, and policy levels. Additionally, by training athletic coaches on prevention of Zika virus transmission, their frequent contacts with athletes can be used to remind athletes about the need for compliance with public health advisories.


id: cord-005885-r3qtoqu1
author: Hellmich, Luisa
title: Exantheme nach Auslandsreisen
date: 2019-10-09
extension: .txt
mime: text/plain
words: 2652
sentence: 148
flesch: 40
cache: cache/cord-005885-r3qtoqu1.txt
txt: txt/cord-005885-r3qtoqu1.txt
summary:
  [8] . Eine Zika-Virus-Infektion verläuft nur in etwa 20 % der Fälle symptomatisch. Das Virus war durch einen Fernreisenden aus Indien eingeschleppt worden und hatte sich dann in einer in der Toskana heimischen Aedes-albopictus-Population ausgebreitet


id: cord-344576-upsc9cf8
author: Taylor-Robinson, Andrew W
date: 2016-07-05
extension: .txt
mime: text/plain
words: 2605
sentence: 102
flesch: 43
cache: cache/cord-344576-upsc9cf8.txt
txt: txt/cord-344576-upsc9cf8.txt
title:
  A vaccine effective against Zika virus is theoretically possible but may not be delivered anytime soon

summary:
  The global spread of Zika virus: is public and media concern justified in regions currently unaffected? Probable non-vector-borne transmission of Zika virus Potential sexual transmission of Zika virus Zika virus: your questions answered Possible Association Between Zika Virus Infection and Microcephaly -Brazil Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study Novel vaccine strategies against emerging viruses A systems biology approach for diagnostic and vaccine antigen discovery in tropical infectious diseases Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa Mosquitoes and their control Local transmission of Zika virus infection is possible in Australia but should be contained by current vector control measures Introducing new vaccines in developing countries A review of successful flavivirus vaccines and the problems with those flaviviruses for which vaccines are not yet available The Guardian BBC News key: cord-344576-upsc9cf8 authors: Taylor-Robinson, Andrew W title: A vaccine effective against Zika virus is theoretically possible but may not be delivered anytime soon date: 2016-07-05 journal: Res Rep Trop Med DOI: 10.2147/rrtm.s108992 sha: doc_id: 344576 cord_uid: upsc9cf8 Following the first report in May 2015 of the unexpected emergence of Zika in north east Brazil, there has been an explosive epidemic of this infection across Latin America.


id: cord-336212-ueh4q408
author: Koenig, Kristi L.
date: 2016-04-04
extension: .txt
mime: text/plain
words: 3599
sentence: 145
flesch: 44
cache: cache/cord-336212-ueh4q408.txt
txt: txt/cord-336212-ueh4q408.txt
title:
  Identify-Isolate-Inform: A Tool for Initial Detection and Management of Zika Virus Patients in the Emergency Department

summary:
  Emergency Committee on Zika virus and observed increase in neurological disorders and neonatal malformations WHO Vector-borne diseases Zika virus in the Americas -Yet another arbovirus threat Guillain-Barre syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study Association between Zika virus and microcephaly in French Polynesia, 2013-15: a retrospective study Centers for Disease Control and Prevention: Webinar-Update on interim Zika virus clinical guidance and recommendations The 2014 Ebola Virus Outbreak and Other Emerging Infectious Diseases Inform: A 3-pronged Approach to Management of Public Health Emergencies Ebola Virus Disease: Essential Identify-Isolate-Inform: Zika Virus Detection and Management Public Health Principles for Clinicians Identify-Isolate-Inform: A Tool for Initial Detection and Management of Measles Patients in the Emergency Department Identify-Isolate-Inform: A modified tool for initial detection and management of Middle East Respiratory Syndrome patients in the emergency department WHO Emergency Preparedness and Response. Zika virus disease will likely have substantially less direct impact on ED operations than other emerging infectious diseases such as the 2009 H1N1 influenza epidemic and 2014 Ebola virus disease outbreak.


id: cord-327948-stwmxpbv
author: Dolai, Subhashish
title: Whole virus detection using aptamers and paper‐based sensor potentiometry
date: 2020-08-01
extension: .txt
mime: text/plain
words: 3980
sentence: 187
flesch: 58
cache: cache/cord-327948-stwmxpbv.txt
txt: txt/cord-327948-stwmxpbv.txt
summary:
  The real-world application of Zika paper sensors will involve the presence of bodily fluids such as urine or sweat or saliva. It showed larger stiction forces with papers coated with aptamers than Zika papers with aptamers or Zika alone, as shown in Fig. 6d .


id: cord-290788-6y0vjhux
author: Wang, Qihui
title: Isolation of Monoclonal Antibodies from Zika Virus-Infected Patient Samples
date: 2020-05-05
extension: .txt
mime: text/plain
words: 4089
sentence: 285
flesch: 71
cache: cache/cord-290788-6y0vjhux.txt
txt: txt/cord-290788-6y0vjhux.txt
summary:
  In the presence of antigens, memory B cells undergo affinity maturation, and their B-cell receptors have increased affinities for the antigen. Studies on memory B cells after smallpox vaccination in humans indicated that antigenspecific memory B cells initially declined postimmunization (1 year) but then reached a plateau~tenfold lower than peak and were stably maintained for >50 years after vaccination [20] .


id: cord-354546-lgkqwm6u
author: Yin, Yingxian
date: 2016-09-07
extension: .txt
mime: text/plain
words: 4093
sentence: 163
flesch: 50
cache: cache/cord-354546-lgkqwm6u.txt
txt: txt/cord-354546-lgkqwm6u.txt
title:
  Epidemiologic investigation of a family cluster of imported ZIKV cases in Guangdong, China: probable human-to-human transmission

summary:
  A bibliometric analysis of global Zika research Zika virus and Guillain-Barre syndrome: another viral cause to add to the list Guillain-Barre syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study Neurological expertise is essential for Zika virus infection Zika virus infects human cortical neural progenitors and attenuates their growth Biology of Zika virus infection in human skin cells Characterization of lethal Zika virus infection in AG129 mice Zika virus: the latest newcomer Zika virus in Gabon (Central Africa)-2007: a new threat from Aedes albopictus The Zika outbreak of the 21st century Probable non-vector-borne transmission of Zika virus Potential sexual transmission of Zika virus Zika: another sexually transmitted infection? An animal model of ZIKV infection has been established in AG129 mice by foot pad injection.


id: cord-284646-fhruiw23
author: Jaeger, Anna S.
date: 2020-05-24
extension: .txt
mime: text/plain
words: 3954
sentence: 128
flesch: 42
cache: cache/cord-284646-fhruiw23.txt
txt: txt/cord-284646-fhruiw23.txt
title:
  Spondweni virus causes fetal harm in Ifnar1(-/-) mice and is transmitted by Aedes aegypti mosquitoes

summary:
  An 783 account of theRockefeller Foundation virus program Zika virus and the nonmicrocephalic fetus: why we should still worry Emerg 790 Spondweni virus infection in a 792 foreign resident of Upper Volta The incidence of arthropod-794 borne viruses in a population of culicine mosquitoes in Tongaland Type I interferons instigate fetal demise after Zika virus infection. key: cord-284646-fhruiw23 authors: Jaeger, Anna S.; Weiler, Andrea M.; Moriarty, Ryan V.; Rybarczyk, Sierra; O'Connor, Shelby L.; O'Connor, David H.; Seelig, Davis M.; Fritsch, Michael K.; Friedrich, Thomas C.; Aliota, Matthew T. title: Spondweni virus causes fetal harm in Ifnar1(-/-) mice and is transmitted by Aedes aegypti mosquitoes date: 2020-05-24 journal: Virology DOI: 10.1016/j.virol.2020.05.005 sha: doc_id: 284646 cord_uid: fhruiw23 Spondweni virus (SPONV) is the most closely related known flavivirus to Zika virus (ZIKV).


id: cord-276916-j53i5xfs
author: Kraemer, M. U. G.
title: Reconstruction and prediction of viral disease epidemics
date: 2018-11-05
extension: .txt
mime: text/plain
words: 4088
sentence: 133
flesch: 31
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txt: txt/cord-276916-j53i5xfs.txt
summary:
  The Lancet Elsevier Ltd Big city, small world: density, contact rates, and transmission of dengue across Pakistan Chains of transmission and control of Ebola virus disease in Conakry Strategies for containing an emerging influenza pandemic in Southeast Asia Inference of R0 and transmission heterogeneity from the size distribution of stuttering chains Detecting differential transmissibilities that affect the size of self-limited outbreaks Using routine surveillance data to estimate the epidemic potential of emerging zoonoses: application to the emergence of US swine origin influenza A H3N2v virus How generation intervals shape the relationship between growth rates and reproductive numbers Similar impacts of control measures Practice of epidemiology a new framework and software to estimate time-varying reproduction numbers during epidemics Real-time estimates in early detection of SARS Exposure patterns driving Ebola transmission in West Africa: a retrospective observational study A Bayesian MCMC approach to study transmission of influenza: application to household longitudinal data Household transmission of 2009 pandemic influenza A (H1N1) virus in the United States Association between antibody titers and protection against influenza virus infection within households Household transmission of influenza virus Role of social networks in shaping disease transmission during a community outbreak of 2009 H1N1 pandemic influenza How social structures, space, and behaviors shape the spread of infectious diseases using chikungunya as a case study Quantifying influenza virus diversity and transmission in humans Mathematical modeling of the West Africa Ebola epidemic Real-time assessment of health-care requirements during the Zika virus epidemic in Martinique Temporal changes in Ebola transmission in Sierra Leone and implications for control requirements: a real-time modelling study Nextstrain: real-time tracking of pathogen evolution Ebola: the power of behaviour change Estimating the future number of cases in the Ebola epidemic -Liberia and Sierra Leone Probabilistic forecasting in infectious disease epidemiology: the 13th Armitage lecture Evaluating probabilistic dengue risk forecasts from a prototype early warning system for Brazil The RAPIDD Ebola forecasting challenge special issue: preface Results from the second year of a collaborative effort to forecast influenza seasons in the United States Real-time, portable genome sequencing for Ebola surveillance Genomic epidemiology reconstructs the introduction and spread of Zika virus in Central America and Mexico Emerging concepts of data integration in pathogen phylodynamics Unraveling the drivers of MERS-CoV transmission Infectious Diseases of Humans: Dynamics and Control Mapping residual transmission for malaria elimination Spatial and temporal dynamics of superspreading events in the 2014-2015 West Africa Ebola epidemic Measuring the path toward malaria elimination Genomic and epidemiological monitoring of yellow fever virus transmission potential Global spread of dengue virus types: mapping the 70 year history Understanding herd immunity Use of serological surveys to generate key insights into the changing global landscape of infectious disease M. U. G. Kraemer http://orcid.org/0000-0001-8838-7147 Ebola virus disease in West Africathe first 9 months of the epidemic and forward projections Zika virus in the Americas: early epidemiological and genetic findings Spread of yellow fever virus outbreak in Angola and the Democratic Republic of the Congo 2015-16: a modelling study The elimination of urban yellow fever in the Americas through the eradication of Aedes aegypti The hidden geometry of complex, network-driven contagion phenomena Emergence and pandemic potential of swine-origin H1N1 influenza virus Unifying viral genetics and human transportation data to predict the global transmission dynamics of human influenza H3N2 Spread of a novel influenza A (H1N1) virus via global airline transportation Who's blueprint list of priority diseases Digital disease detection -harnessing the web for public health surveillance Updates to the zoonotic niche map of Ebola virus disease in Africa Mapping the zoonotic niche of Marburg virus disease in Africa Towards a genomics-informed, real-time, global pathogen surveillance system Modeling infectious disease dynamics in the complex landscape of global health The global distribution and burden of dengue Progress and challenges in infectious disease cartography Global distribution and environmental suitability for chikungunya virus Mapping global environmental suitability for Zika virus Mapping the zoonotic niche of Ebola virus disease in Africa Mapping the zoonotic niche of Lassa fever in Africa Existing and potential infection risk zones of yellow fever worldwide: a modelling analysis Model-based projections of Zika virus infections in childbearing women in the Americas Assessing Seasonal Risks for the introduction and Mosquito-borne spread of Zika virus in Europe Potential for Zika virus introduction and transmission in resource limited countries in Africa and Asia-Pacific Assessment of the potential for international dissemination of Ebola virus via commercial air travel during the 2014 West African outbreak Zika virus transmission in Angola and the potential for further spread to other African settings Nowcasting the spread of chikungunya virus in the Americas Local and regional spread of chikungunya fever in the Americas Yellow Fever in Africa: estimating the burden of disease and impact of mass vaccination from outbreak and serological data The revised global yellow fever risk map and recommendations for vaccination, 2010: consensus of the informal WHO working group on geographic risk for yellow fever Global yellow fever vaccination coverage from 1970 to 2016: an adjusted retrospective analysis.


id: cord-266202-3qku90ml
author: Billington, John
date: 2020-06-01
extension: .txt
mime: text/plain
words: 4325
sentence: 187
flesch: 37
cache: cache/cord-266202-3qku90ml.txt
txt: txt/cord-266202-3qku90ml.txt
title:
  Developing Vaccines for SARS-CoV-2 and Future Epidemics and Pandemics: Applying Lessons from Past Outbreaks

summary:
  EIDs are a particularly challenging target for global health preparedness, including for vaccine development. Insufficient attention has been given to challenges, lessons learned, and potential solutions to support and sustain vaccine industry engagement in vaccine development for EIDs.


id: cord-283314-i59ewz88
author: Chidiac, C.
title: Agents infectieux émergents
date: 2016-09-17
extension: .txt
mime: text/plain
words: 4175
sentence: 198
flesch: 56
cache: cache/cord-283314-i59ewz88.txt
txt: txt/cord-283314-i59ewz88.txt
summary:
  Les anomalies biologiques associent lymphopénie initiale (3-5 premiers jours), suivie d'une hyperleucocytose à polynucléaires neutrophiles, thrombopénie, coagulation intravasculaire disséminée (CIVD), augmentation des transaminases (parfois considérable, portant plus sur les SGOT que les SGPT), de l'amylase, de la bilirubine, et des LDH. la lutte antivectorielle à l'échelle de territoires, réalisée par des opérateurs publics de démoustication, (ii) la lutte communautaire, de la responsabilité de tous, réalisée par la destruction des gîtes larvaires potentiels autour des habitations (eau stagnante dans les soucoupes, gouttières, vases, seaux, détritus. . .)


id: cord-016663-qnp99m7o
author: Taylor, Robert B.
title: Medical Words Linked to Places
date: 2017-02-01
extension: .txt
mime: text/plain
words: 4837
sentence: 226
flesch: 61
cache: cache/cord-016663-qnp99m7o.txt
txt: txt/cord-016663-qnp99m7o.txt
summary:
  This chapter is about diseases named for places. If a young physician today were asked to identify a disease named for a place, the answer might well be Lyme disease, also called Lyme borreliosis.


id: cord-354848-7aakik9a
author: Sayres, Lauren
title: Contemporary Understanding of Ebola and Zika Virus in Pregnancy
date: 2020-10-16
extension: .txt
mime: text/plain
words: 4376
sentence: 191
flesch: 36
cache: cache/cord-354848-7aakik9a.txt
txt: txt/cord-354848-7aakik9a.txt
summary:
  I. Isolations and serological specificity Zika virus: a report on three cases of human infection during an epidemic of jaundice in Nigeria Zika virus Concurrent outbreaks of dengue, chikungunya and Zika virus infections -an unprecedented epidemic wave of mosquito-borne viruses in the Pacific Zika virus spreads to new areas -region of the Americas Zika virus infection -after the pandemic Zika virus infection in pregnant women in Rio de Janeiro Pregnancy outcomes after maternal Zika virus infection during pregnancy Zika virus infection during pregnancy and microcephaly occurrence: a review of literature and Brazilian data Transmission of Zika virus through breast milk and other breastfeeding-related bodily-fluids: a systematic review Pathogenesis of flavivirus infections: using and abusing the host cell Zika virus infects human cortical neural progenitors and attenuates their growth ZIKA virus reveals broad tissue and cell tropism during the first trimester of pregnancy Zika virus pathogenesis and tissue tropism Emergence of congenital zika syndrome: viewpoint from the front lines Congenital brain abnormalities and zika virus: what the radiologist can expect to see prenatally and postnatally Ultrasound imaging for identification of cerebral damage in congenital Zika virus syndrome: a case series Characterizing the pattern of anomalies in congenital zika syndrome for pediatric clinicians Update: interim guidance for health care providers caring for pregnant women with possible zika virus exposure -United States Management of patients in the context of zika virus: ACOG committee opinion, number 784 ISUOG Interim Guidance on ultrasound for Zika virus infection in pregnancy: information for healthcare professionals Dengue and Zika virus diagnostic testing for patients with a clinically compatible illness and risk for infection with both viruses Associated ultrasonographic findings in fetuses with microcephaly because of suspected Zika virus (ZIKV) infection during pregnancy Analysis of blood from Zika virus-infected fetuses: a prospective case series Host-directed antivirals: a realistic alternative to fight zika virus Computer-assisted and data driven approaches for surveillance, drug discovery, and vaccine design for the Zika virus Investigational drugs for the treatment of Zika virus infection: a preclinical and clinical update Zika vaccines and therapeutics: landscape analysis and challenges ahead Beta Adrenergic receptor-mediated regulation of cyclic nucleotide phosphodiesterase in C6 glioma cells: vinblastine blockade of isoproterenol induction Prevention and control strategies to counter zika virus, a special focus on intervention approaches against vector mosquitoes-current updates Personal actions to minimize mosquito-borne illnesses, including zika virus Mosquito-borne diseases as a global health problem: implications for pregnancy and travel Preventing transmission of zika virus in labor and delivery settings through implementation of standard precautions -United States An integrative review of the limited evidence on international travel bans as an emerging infectious disease disaster control measure Rapid spread of zika virus in the Americasimplications for public health preparedness for mass Blood & tissue safety: geographic areas at increased risk for Zika virus transmission through blood or tissue donation Mitigating prenatal zika virus infection in the Americas Preliminary aggregate safety and immunogenicity results from three trials of a purified inactivated Zika virus vaccine candidate: phase 1, randomised, double-blind, placebo-controlled clinical trials Safety and pharmacokinetics of broadly neutralising human monoclonal antibody VRC07-523LS in healthy adults: a phase 1 dose-escalation clinical trial Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials Zika vaccine development: current status Potential maternal and infant outcomes from (Wuhan) coronavirus 2019-nCoV infecting pregnant women: lessons from SARS, MERS, and other human coronavirus infections Addressing the effects of established and emerging infections during pregnancy Zika virus infection is typically detected by serum and urine RT PCR nucleic acid molecular screening and/or serologic IgM ELISA screening.


id: cord-320940-e7ic2pnc
author: Yang, Jiancheng
title: Nanosensor networks for health-care applications
date: 2020-02-14
extension: .txt
mime: text/plain
words: 5283
sentence: 206
flesch: 42
cache: cache/cord-320940-e7ic2pnc.txt
txt: txt/cord-320940-e7ic2pnc.txt
summary:
  The new high resolution crystal structure of NS2B-NS3 protease of Zika virus Structure of the immature Zika virus at 9Å resolution The 3.8Å resolution cryo-EM structure of Zika virus Structural features of Zika virus non-structural proteins 3 and -5 and its individual domains in solution as well as insights into NS3 inhibition Postnatal identification of Zika virus peptides from saliva Botulinum toxin as a biological weapon: medical and public health management Microbiological, biological, and chemical weapons of warfare and terrorism Botulinum toxin detection using AlGaN/GaN high electron mobility transistors Long-term stability study of botulinum toxin detection with AlGaN/GaN high electron mobility transistor based sensors Electrical detection of biomaterials using AlGaN/GaN high electron mobility transistors Mercury levels along the food chain and risk for exposed populations Concentrations of arsenic, cadmium, mercury, and lead in common foods and estimated daily intake by children, adolescents, adults, and seniors of Catalonia, Spain A review of the studies of the cardiovascular health effects of methylmercury with consideration of their suitability for risk assessment Low dose mercury toxicity and human health Mercury and autism: accelerating evidence? Mercury (II) selective sensors based on AlGaN/GaN transistors AlGaN/GaN-based biosensor for label-free detection of biological activity Sensors using AlGaN/GaN based high electron mobility transistor for environmental and bio-applications Fast electrical detection of Hg(II) ions with AlGaN/GaN high electron mobility transistors Selective detection of Hg(II) ions from Cu(II) and Pb(II) using AlGaN/GaN high electron mobility transistors A mercury(II) selective sensor based on N,N 0 -bis(salicylaldehyde)-phenylenediamine as neutral carrier for potentiometric analysis in water samples The potential use of saliva to detect recurrence of disease in women with breast carcinoma The use of soluble, salivary c-erbB-2 for the detection and post-operative follow-up of breast cancer in women: the results of a five-year translational research study The use of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry to detect putative breast cancer markers in saliva: a feasibility study Salivary analysis in the diagnosis and treatment of breast cancer: a role for the general dentist c-erbB-2 sensing using AlGaN/GaN high electron mobility transistors for breast cancer detection Prostate-specific antigen doubling time as a surrogate marker for evaluation of oncologic drugs to treat prostate cancer Prostate-specific antigen in the early detection of prostate cancer Biosensor developments: application to prostate-specific antigen detection Prostate specific antigen detection using AlGaN/GaN high electron mobility transistors The bloodÀbrain barrier: an overview Implications of the discovery of brain lymphatic pathways Diagnostic relevance of β2-transferrin for the detection of cerebrospinal fluid fistulas Surgical repair of spontaneous CSF leaks: a systematic review Otolaryngology Head and Neck Surgery Detection of beta-2 transferrin in otorrhea and rhinorrhea in a routine clinical laboratory setting Clinical experience with beta-trace protein as a marker for cerebrospinal fluid Retrospective study of endoscopic management of CSF rhinorrhoea-a case series Comprehensive algorithm for skull base dural lesion and cerebrospinal fluid fistula diagnosis Skull base cerebrospinal fluid fistulas: a comprehensive diagnostic algorithm Comparison of β-2-transferrin and β-trace protein for detection of cerebrospinal fluid in nasal and ear fluids Perilymph detection by β2-transferrin immunoblotting assay. Particle-based assays allow for multiple detections by using multiple beads, but the whole detection process is generally longer than 2 hours, which is not practical for in-office or bedside detection.


id: cord-010996-2ua7dzjk
author: Olawoyin, Omomayowa
date: 2020-01-14
extension: .txt
mime: text/plain
words: 5738
sentence: 199
flesch: 46
cache: cache/cord-010996-2ua7dzjk.txt
txt: txt/cord-010996-2ua7dzjk.txt
title:
  Coinfection, Altered Vector Infectivity, and Antibody-Dependent Enhancement: The Dengue–Zika Interplay

summary:
  Infection of mosquito cells (c6/36) by dengue-2 virus interferes with subsequent infection by yellow fever virus Dynamic epidemiological models for dengue transmission: a systematic review of structural approaches Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity A survey of mathematical models of dengue fever Cocirculation and simultaneous co-infection of dengue, chikungunya, and Zika viruses in patients with febrile syndrome at the Colombian-Venezuelan border Utility of a dengue-derived monoclonal antibody to enhance Zika infection in vitro Coinfection with Zika virus (ZIKV) and dengue virus results in preferential ZIKV transmission by vector bite to vertebrate host The impact of vaccination and coinfection on HPV and cervical cancer Dengue virus sero-cross-reactivity drives antibodydependent enhancement of infection with Zika virus Co-infection with Zika and dengue viruses in 2 patients Dengue antibody and Zika: friend or foe? Prevention and control of Zika as a mosquito-borne and sexually transmitted disease: a mathematical modeling analysis Prior exposure to Zika virus significantly enhances peak dengue-2 viremia in rhesus macaques A preliminary mathematical model for the dynamic transmission of dengue, chikungunya and Zika Zika virus-induced antibody response enhances dengue virus serotype 2 replication in vitro Dengue: epidemiology, prevention and pressing need for vaccine development Coinfection with Zika and dengue-2 viruses in a traveler returning from Haiti, 2016: clinical presentation and genetic analysis Sequential infection of Aedes aegypti mosquitoes with chikungunya virus and Zika virus enhances early Zika virus transmission Comparing dengue and chikungunya emergence and endemic transmission in A. aegypti and A. albopictus A non-autonomous multi-strain SIS epidemic model Invasion reproductive numbers for periodic epidemic systems Determinants of mortality from severe dengue in Brazil: a population-based case-control study Discovery of fifth serotype of dengue virus (DENV-5): a new public health dilemma in dengue control The unholy chikungunya-dengue-Zika trinity: a theoretical analysis Effects of multiple transmission pathways on Zika dynamics Provisional remarks on Zika virus infection in pregnant women: document for health care professionals Dengue virus antibodies enhance Zika virus infection Designing HIV vaccination policies: subtypes and cross-immunity Impact of simultaneous exposure to arboviruses on infection and transmission by Aedes aegypti mosquitoes Estimating the reproductive number, total outbreak size, and reporting rates for Zika epidemics in South and Central America Specificity, cross-reactivity and function of antibodies elicited by Zika virus infection Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission Viremia and clinical presentation in Nicaraguan patients infected with Zika virus, chikungunya virus, and dengue virus Dynamics analysis of a Zika-dengue co-infection model with dengue vaccine and antibody-dependent enhancement Prospects for a dengue virus vaccine Dynamics of Zika virus outbreaks: an overview of mathematical modeling approaches World Health Organization (2012) Global strategy for dengue prevention and control 2012-2020. Many in vitro studies (e.g., Charles and Christofferson 2016; Dejnirattisai et al. 2016; Durbin 2016; Paul et al. 2016 ) have shown that dengue antibodies cross-react with the ZIKV, increasing Zika infection of cells and production of viral progeny by over 100-fold.


id: cord-326512-iex98lr1
author: Niu, Xuefeng
date: 2019-05-25
extension: .txt
mime: text/plain
words: 5674
sentence: 239
flesch: 53
cache: cache/cord-326512-iex98lr1.txt
txt: txt/cord-326512-iex98lr1.txt
title:
  Convalescent patient-derived monoclonal antibodies targeting different epitopes of E protein confer protection against Zika virus in a neonatal mouse model

summary:
  For antigen-specific memory B cells, we used ZIKV E protein (Cat. no. 40543-V08B4; Sino Biological Inc., Beijing, China) as a probe. Amino acid sequence alignment between E proteins of ZIKV and DENV revealed that residue K394 on ZIKV E protein corresponds to K385 on DENV1, which is not present on the E proteins of DENV2, DENV3, or DENV4 ( Figure 2(D) ).


id: cord-298166-045evk7g
author: Röcker, Annika E.
title: The molecular tweezer CLR01 inhibits Ebola and Zika virus infection
date: 2018-02-08
extension: .txt
mime: text/plain
words: 5846
sentence: 237
flesch: 49
cache: cache/cord-298166-045evk7g.txt
txt: txt/cord-298166-045evk7g.txt
summary:
  Detection of Zika virus in semen Safety and pharmacological characterization of the molecular tweezer CLR01-a broad-spectrum inhibitor of amyloid proteins' toxicity Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers A screen of FDA-approved drugs for inhibitors of Zika virus infection Lipid raft microdomains Combating emerging viral threats The HIV lipidome: a raft with an unusual composition Drug Selectivity: an Evolving Concept in Medicinal Chemistry Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study Ebola Outbreak in West Africa -Case Counts Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides Virus entry, assembly, budding, and membrane rafts. As no preventive vaccines or antiviral drugs against these two re-emerging pathogens are available, we evaluated whether the molecular tweezer CLR01 may inhibit EBOV and ZIKV infection.


id: cord-321741-aq76s37x
author: Andersen, Petter I.
title: Discovery and development of safe-in-man broad-spectrum antiviral agents
date: 2020-04-30
extension: .txt
mime: text/plain
words: 5447
sentence: 168
flesch: 26
cache: cache/cord-321741-aq76s37x.txt
txt: txt/cord-321741-aq76s37x.txt
summary:
  RFP-expressing RVFV, nanoLuc-expressing CHIKV and RRV, as well as GFP-expressing FLUAV, HCV and HMPV also allowed identification of novel activities of several BSAAs (Andersen et al., 2019b; Bosl et al., 2019; de Graaf et al., 2007; Habjan et al., 2008; Ianevski et al., 2018; Jupille et al., 2011; Kittel et al., 2004; Lee et al., 2017; Utt et al., 2016) . Therefore, repositioning of launched or even failed drugs to viral diseases provides unique translational opportunities, including a substantially higher probability of success to market as compared with developing new virus-specific drugs and vaccines, and a significantly reduced cost and timeline to clinical availability Pizzorno et al., 2019; Zheng et al., 2018) .


id: cord-260336-kwzo8puo
author: Si, Lulu
date: 2019-09-27
extension: .txt
mime: text/plain
words: 6407
sentence: 262
flesch: 54
cache: cache/cord-260336-kwzo8puo.txt
txt: txt/cord-260336-kwzo8puo.txt
title:
  A Peptide-Based Virus Inactivator Protects Male Mice Against Zika Virus-Induced Damage of Testicular Tissue

summary:
  To determine the protective effect of Z2 on ZIKV infection of testicular tissue, we tested if Z2 could inhibit infection by different ZIKV strains of Asian and African lineages in mouse Sertoli TM4 cells, which are nurse-like cells that support spermatogenesis (Wei et al., 2018) and important target cells for ZIKV testicular infection. However, no drug has been approved for prevention or treatment of ZIKV infection, especially infection in male testicular tissue.


id: cord-288703-wdh1jiry
author: Ishtiaq, Farah
title: A Call to Introduce Structured Zika Surveillance in India
date: 2017-11-15
extension: .txt
mime: text/plain
words: 3044
sentence: 124
flesch: 43
cache: cache/cord-288703-wdh1jiry.txt
txt: txt/cord-288703-wdh1jiry.txt
summary:
  PMX is targeted to exonemes [2] , among the earliest parasite organelles discharged during egress, and is required in vivo for proteolytic maturation of the serine protease Neutralizing antibodies against certain viruses in the sera of residents of India Elevation as a proxy for mosquitoborne Zika virus transmission in the Americas Culex pipiens quinquefasciatus: a potential vector to transmit Zika virus Zika virus replication in the mosquito Culex quinquefasciatus in Brazil Potential for Zika virus introduction and transmission in resource-limited countries in Africa and the Asia-Pacific region: a modelling study Arbovirus survey in wild birds in Uganda A survey for arboviral antibodies in sera of humans and animals in Lombok, Republic of Indonesia Genomic epidemiology reveals multiple introductions of Zika virus into the United States Zika virus: medical countermeasure development challenges Zika virus infection and associated neurologic disorders in Brazil A confirmed case of Zika virus disease requires laboratory confirmation of infection by either the presence of Zika virus RNA or of antigen in serum or other samples (e.g., saliva, tissues, urine, whole blood); or alternatively the detection of IgM antibodies against Zika virus.


id: cord-003187-qdbcdn2j
author: Bassi, Maria Rosaria
date: 2018-08-27
extension: .txt
mime: text/plain
words: 6761
sentence: 211
flesch: 30
cache: cache/cord-003187-qdbcdn2j.txt
txt: txt/cord-003187-qdbcdn2j.txt
title:
  Extinction of Zika Virus and Usutu Virus by Lethal Mutagenesis Reveals Different Patterns of Sensitivity to Three Mutagenic Drugs

summary:
  The crystal structure of Zika virus NS5 reveals conserved drug targets Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase Analysis of ribonucleotide 5=-triphosphate analogs as potential inhibitors of Zika virus RNAdependent RNA polymerase using non-radioactive polymerase assays Curing of foot-and-mouth disease virus from persistently infected cells by ribavirin involves enhanced mutagenesis Mode of action of ribavirin: effect of nucleotide pool alterations on influenza virus ribonucleoprotein synthesis Persistence of West Nile virus Zika virus persistence in the central nervous system and lymph nodes of rhesus monkeys The role of viral persistence in flavivirus biology Mutagenesis-induced, large fitness variations with an invariant arenavirus consensus genomic nucleotide sequence Zika virus infection of rhesus macaques leads to viral persistence in multiple tissues Late sexual transmission of Zika virus related to persistence in the semen Sexually acquired Zika virus: a systematic review Update: interim guidance for prevention of sexual transmission of Zika virus-United States Persistent detection of Zika virus RNA in semen for six months after symptom onset in a traveller returning from Haiti to Italy, February 2016 Mosquito-borne and sexual transmission of Zika virus: recent developments and future directions Prevention and control of Zika as a mosquito-borne and sexually transmitted disease: a mathematical modeling analysis The risk of sustained sexual transmission of Zika is underestimated Zika virus infects human placental macrophages Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model The viral polymerase inhibitor 7-deaza-2=-C-methyladenosine is a potent inhibitor of in vitro Zika virus replication and delays disease progression in a robust mouse infection model The race to find antivirals for Zika virus First evidence of simultaneous occurrence of West Nile virus and Usutu virus neuroinvasive disease in humans in Croatia during the 2013 outbreak Limited susceptibility of mice to Usutu virus (USUV) infection and induction of flavivirus cross-protective immunity A recombinant DNA vaccine protects mice deficient in the alpha/beta interferon receptor against lethal challenge with Usutu virus Emergence of Usutu virus, an African mosquito-borne Flavivirus of the Japanese encephalitis virus group Virus isolation and quantitation Isolation of fidelity variants of RNA viruses and characterization of virus mutation frequency Norovirus polymerase fidelity contributes to viral transmission in vivo A rapid and specific real-time RT-PCR assay to identify Usutu virus in human plasma, serum, and cerebrospinal fluid Coxsackievirus B3 mutator strains are attenuated in vivo


id: cord-300459-tu2xrt9x
author: Li, Cui
date: 2018-05-01
extension: .txt
mime: text/plain
words: 6849
sentence: 269
flesch: 50
cache: cache/cord-300459-tu2xrt9x.txt
txt: txt/cord-300459-tu2xrt9x.txt
title:
  A Single Injection of Human Neutralizing Antibody Protects against Zika Virus Infection and Microcephaly in Developing Mouse Embryos

summary:
  To address this, we investigated six human monoclonal antibodies with ZIKV epitope specificity and neutralizing activity in mouse models of ZIKV infection and microcephaly. A single intraperitoneal injection of these antibodies conveyed distinct levels of adult and in utero protection from ZIKV infection, which closely mirrored their respective in vitro neutralizing activities.


id: cord-273326-gmw8gl2r
author: Saiz, Juan-Carlos
title: Host-Directed Antivirals: A Realistic Alternative to Fight Zika Virus
date: 2018-08-24
extension: .txt
mime: text/plain
words: 7153
sentence: 232
flesch: 28
cache: cache/cord-273326-gmw8gl2r.txt
txt: txt/cord-273326-gmw8gl2r.txt
summary:
  Front Pathogenic exploitation of Fc activity Pathogenesis of flavivirus infections: Using and abusing the host cell Role of host cell factors in flavivirus infection: Implications for pathogenesis and development of antiviral drugs Broad-spectrum agents for flaviviral infections: Dengue, zika and beyond Targeting host factors to treat West Nile and dengue viral infections Zika virus replicons for drug discovery Establishment and application of flavivirus replicons Probing molecular insights into Zika virus (-)host interactions Zika virus cell tropism in the developing human brain and inhibition by azithromycin Genetic ablation of axl does not protect human neural progenitor cells and cerebral organoids from Zika virus infection Axl mediates Zika virus entry in human glial cells and modulates innate immune responses Axl is not an indispensable factor for Zika virus infection in mice Axl-mediated productive infection of human endothelial cells by Zika virus Curcumin inhibits zika and chikungunya virus infection by inhibiting cell binding Polysulfonate suramin inhibits Zika virus infection Suramin inhibits Zika virus replication by interfering with virus attachment and release of infectious particles Molecular mechanisms of flavivirus membrane fusion Acid-dependent viral entry Screening bioactives reveals nanchangmycin as a broad spectrum antiviral active against Zika virus Lipids and flaviviruses, present and future perspectives for the control of dengue, zika, and West Nile viruses Arbidol (umifenovir): A broad-spectrum antiviral drug that inhibits medically important arthropod-borne flaviviruses Infection by Zika viruses requires the transmembrane protein AXL, endocytosis and low pH 25-hydroxycholesterol protects host against Zika virus infection and its associated microcephaly in a mouse model A screen of FDA-approved drugs for inhibitors of Zika virus infection Obatoclax, saliphenylhalamide and gemcitabine inhibit Zika virus infection in vitro and differentially affect cellular signaling, transcription and metabolism Obatoclax inhibits alphavirus membrane fusion by neutralizing the acidic environment of endocytic compartments Evaluation of anti-Zika virus activities of broad-spectrum antivirals and NIH clinical collection compounds using a cell-based, high-throughput screen assay Chloroquine, an endocytosis blocking agent, inhibits Zika virus infection in different cell models Antiviral activities of selected antimalarials against dengue virus type 2 and Zika virus Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice FDA-approved drug, prevents Zika virus infection and its associated congenital microcephaly in mice Repurposing of the anti-malaria drug chloroquine for Zika virus treatment and prophylaxis -(arylmethylimino)ethyl)-7-chloroquinolin-4-amine derivatives, synthesized by thermal and ultrasonic means, are endowed with anti-Zika virus activity (trifluoromethyl)quinoline analogs show improved anti-Zika virus activity, compared to mefloquine The antimalarial drug amodiaquine possesses anti-Zika virus activities Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen Niclosamide rescues microcephaly in a humanized in vivo model of zika infection using human induced neural stem cells Antiviral effects of ferric ammonium citrate Inhibition of Zika virus replication by silvestrol Antiviral activity of N-(4-hydroxyphenyl) retinamide (4-HPR) against Zika virus Interferon-induced spermidine-spermine acetyltransferase and polyamine depletion restrict zika and chikungunya viruses Inhibition of polyamine biosynthesis is a broad-spectrum strategy against rna viruses The composition of West Nile virus lipid envelope unveils a role of sphingolipid metabolism in flavivirus biogenesis Direct activation of adenosine monophosphate-activated protein kinase (AMPK) by PF-06409577 inhibits flavivirus infection through modification of host cell lipid metabolism Suppression of Zika virus infection and replication in endothelial cells and astrocytes by PKA inhibitor PKI 14-22 Zika virus targets human STAT2 to inhibit type I interferon signaling Ribavirin-Current status of a broad spectrum antiviral agent Broad-spectrum antiviral activity of the imp dehydrogenase inhibitor VX-497: A comparison with ribavirin and demonstration of antiviral additivity with alpha interferon Rna virus error catastrophe: Direct molecular test by using ribavirin Extinction of hepatitis c virus by ribavirin in hepatoma cells involves lethal mutagenesis Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model In vitro susceptibility of geographically and temporally distinct Zika viruses to favipiravir and ribavirin Ribavirin inhibits Zika virus (zikv) replication in vitro and suppresses viremia in zikv-infected stat1-deficient mice Favipiravir and ribavirin inhibit replication of Asian and African strains of Zika virus in different cell models an impdh inhibitor, suppresses replication of Zika virus and other emerging viral pathogens A sensitive virus yield assay for evaluation of antivirals against Zika virus Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity Discovery of a broad-spectrum antiviral compound that inhibits pyrimidine biosynthesis and establishes a type 1 interferon-independent antiviral state High-content screening in HPSC-neural progenitors identifies drug candidates that inhibit Zika virus infection in fetal-like organoids and adult brain The Brazilian Zika virus strain causes birth defects in experimental models Zika virus impairs growth in human neurospheres and brain organoids Zika virus disrupts neural progenitor development and leads to microcephaly in mice N-methyl-D-aspartate (NMDA) receptor blockade prevents neuronal death induced by Zika virus infection Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmission Zika virus infectious cell culture system and the in vitro prophylactic effect of interferons Type iii interferons produced by human placental trophoblasts confer protection against Zika virus infection Gestational stage and IFN-lambda signaling regulate ZIKV infection in utero The IFITMs inhibit Zika virus replication


id: cord-319781-6thdg2up
author: Payne, Kelly
date: 2020-07-24
extension: .txt
mime: text/plain
words: 8239
sentence: 343
flesch: 45
cache: cache/cord-319781-6thdg2up.txt
txt: txt/cord-319781-6thdg2up.txt
title:
  Twenty-First Century Viral Pandemics: A Literature Review of Sexual Transmission and Fertility Implications in Men

summary:
  SARS-Cov-2, the most recent viral pandemic included in this review, is expected to behave similar to SARS virus, but further data are required to validate these assumptions. ELevated 17b-estradiol protects females from influenza A virus pathogenesis by suppressing inflammatory responses Critically ill children during the 2009-2010 influenza pandemic in the United States Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection Probable noneVectorborne transmission of Zika virus Persistence and clinical relevance of Zika virus in the male genital tract Zika virus shedding in semen of symptomatic infected men Effect of acute Zika virus infection on sperm and virus clearance in body fluids: a prospective observational study Sexual transmission of Zika virus and other flaviviruses: a living systematic review Persistence of Zika virus in body fluids -Final report Zika virus infects human testicular tissue and germ cells Sexually acquired Zika virus: a systematic review Low risk of a sexuallytransmitted Zika virus outbreak The dual role of the immune response in reproductive organs during Zika virus infection Zika virus causes testicular atrophy Zika virus infection damages the testes in mice Zika virus in semen: a prospective cohort study of symptomatic travellers returning to Belgium Potential effect of Zika virus infection on human male fertility? Ebola (Ebola Virus Disease)


id: cord-295351-0zr2e8lh
author: Mohd Ropidi, Muhammad Izzuddin
title: Endoplasmic reticulum: a focal point of Zika virus infection
date: 2020-01-20
extension: .txt
mime: text/plain
words: 7858
sentence: 334
flesch: 32
cache: cache/cord-295351-0zr2e8lh.txt
txt: txt/cord-295351-0zr2e8lh.txt
summary:
  ZIKV proteins localize to distinct subcellular compartments ZIKV proteins are primarily distributed within and in close proximity to several endomembrane compartments including the endoplasmic reticulum, Golgi apparatus, endosomes, lysosomes, autophagosomes, and nucleus The subcellular distribution of certain ZIKV proteins was corroborated in a separate study where interatomic analyses using proximity-dependent biotin-identification (BioID) labeling and FLAG-based immunoprecipitation (IP) coupled with mass spectrometry (MS) uncover indepth molecular interactions between ZIKV proteins with various host organelles and proteins.


id: cord-290385-0smnl70i
author: Chan, Jasper F.W.
title: Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease
date: 2016-03-03
extension: .txt
mime: text/plain
words: 8262
sentence: 319
flesch: 36
cache: cache/cord-290385-0smnl70i.txt
txt: txt/cord-290385-0smnl70i.txt
summary:
  Domain III peptides from flavivirus envelope protein are useful antigens for serologic diagnosis and targets for immunization A single mutation in chikungunya virus affects vector specificity and epidemic potential Spread of the pandemic Zika virus lineage is associated with NS1 codon usage adaptation in humans Biology of Zika virus infection in human skin cells Autophagy and viral diseases transmitted by Aedes aegypti and Aedes albopictus Zika virus infection of the central nervous system of mice Zika virus: further isolations in the Zika area, and some studies on the strains isolated Persistence of arboviruses and antiviral antibodies in vertebrate hosts: its occurrence and impacts Incubation periods of mosquito-borne viral infections: a systematic review Rapid risk assessment: Zika virus infection outbreak, French Polynesia Current Zika virus epidemiology and recent epidemics Zika virus outbreak Zika virus infection in man Zika virus infection, Cambodia Fatal Zika virus infection in girl with sickle cell disease, Colombia. Zika situation report e neurological syndrome and congenital anomalies Zika virus infection acquired during brief travel to Indonesia First case of Zika virus infection in a returning Canadian traveler Two cases of Zika fever imported from French Polynesia to Japan First case of laboratory-confirmed Zika virus infection imported into Europe Zika virus infection after travel to Tahiti Zika virus infection in a traveller returning to Europe from Brazil Zika virus infections imported to Italy: clinical, immunological and virological findings, and public health implications Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase Zika virus in an American recreational traveler Acute Zika virus infection after travel to Malaysian Borneo Zika fever imported from Thailand to Japan, and diagnosed by PCR in the urines Zika virus infection in a traveller returning from the Maldives Epidemiological alert e neurological syndrome, congenital malformations, and Zika virus infection.


id: cord-339886-th1da1bb
author: Gardy, Jennifer L.
title: Towards a genomics-informed, real-time, global pathogen surveillance system
date: 2017-11-13
extension: .txt
mime: text/plain
words: 8778
sentence: 251
flesch: 23
cache: cache/cord-339886-th1da1bb.txt
txt: txt/cord-339886-th1da1bb.txt
summary:
  As genomics has moved into the domain of clinical and public health practice, the notion of free and im mediate access to genomic surveillance data has encountered several barriers: the siloing of critical metadata across multiple public health databases with no interoperability; balancing openness and transparency with patient privacy and safety; variable data quality, particularly in resource-limited settings; concerns over data reuse by third parties; a lack of standards and ontologies to capture metadata; and career advancement disincentives to releasing data [107] EIDs are driven by multiple factors, many of which have digital outputs and represent novel sources of surveillance data 91 .


id: cord-296309-i1mpov7k
author: Houldcroft, Charlotte J.
title: Clinical and biological insights from viral genome sequencing
date: 2017-01-16
extension: .txt
mime: text/plain
words: 9059
sentence: 259
flesch: 23
cache: cache/cord-296309-i1mpov7k.txt
txt: txt/cord-296309-i1mpov7k.txt
summary:
  The concentration of virus particles (see the Zika virus example above 72 ), depletion of host material and/or sequencing to high read depth can increase the amount of virus sequence, but all of these methods add to the cost. This is particularly relevant for rapid responses to emerging threats, such as Zika virus 81 .


id: cord-293562-69nnyq8p
author: Imran, Mudassar
date: 2018-08-15
extension: .txt
mime: text/plain
words: 5874
sentence: 287
flesch: 51
cache: cache/cord-293562-69nnyq8p.txt
txt: txt/cord-293562-69nnyq8p.txt
title:
  Mathematical analysis of the role of hospitalization/isolation in controlling the spread of Zika fever

summary:
  The dynamics of Zika fever epidemic model have been considered. Susceptible individuals get infected with Zika fever virus (due to contact with infected vectors) at a rate λ h and thus enter the exposed class E h .


id: cord-003792-v48xeqdz
author: Izquierdo-Suzán, Mónica
title: Natural Vertical Transmission of Zika Virus in Larval Aedes aegypti Populations, Morelos, Mexico
date: 2019-08-17
extension: .txt
mime: text/plain
words: 4025
sentence: 120
flesch: 36
cache: cache/cord-003792-v48xeqdz.txt
txt: txt/cord-003792-v48xeqdz.txt
summary:
  Vertical transmission of Zika virus in Ae. aegypti mosquitoes has been evaluated under laboratory conditions by searching for the presence of Zika virus RNA in several organs from the offspring of infected mosquitoes, demonstrating the presence of viral RNA in the guts and salivary glands of the offspring (12) . Only a few studies have addressed the natural vertical transmission of Zika virus in wild mosquito populations; most of these have been carried out in Brazil, where Zika virus RNA has been detected in male Ae. aegypti mosquitoes and in adult Ae. albopictus mosquitoes raised from field-collected eggs (26, 27) .


id: cord-002952-13v4qvhg
author: Johansson, Michael A.
title: Preprints: An underutilized mechanism to accelerate outbreak science
date: 2018-04-03
extension: .txt
mime: text/plain
words: 2220
sentence: 92
flesch: 41
cache: cache/cord-002952-13v4qvhg.txt
txt: txt/cord-002952-13v4qvhg.txt
summary:
  These likely represent the majority of Zika preprints, though others may have been posted in ad hoc, lesser-known, or laboratory-or university-specific webpages or repositories. Although preprint adoption in both outbreaks was very low, 4 important advances were clear.


id: cord-002921-i5jxn1vj
author: Morens, David M
title: Pandemic Zika: A Formidable Challenge to Medicine and Public Health
date: 2017-12-15
extension: .txt
mime: text/plain
words: 1979
sentence: 76
flesch: 35
cache: cache/cord-002921-i5jxn1vj.txt
txt: txt/cord-002921-i5jxn1vj.txt
summary:
  August Hirschwald The perpetual challenge of infectious diseases Zika Virus in the Americas-Yet Another Arbovirus Threat History and emergence of Zika virus Epidemiology of Zika virus infection Quantifying Zika: advancing the epidemiology of Zika with quantitative models Modes of transmission of Zika virus Zika virus mosquito vectors: competence, biology and vector control Zika virus evolution and spread in the Americas Diagnosis of Zika virus infections: challenges and opportunities A Zika virus from America is more efficiently transmitted than an Asian virus by Aedes aegypti mosquitoes from Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes Meeting the challenge of epidemic chikungunya Zika virus structure, maturation and receptors Neurological implications of Zika virus in the adult population Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity Antibody-dependent enhancement of infection and the pathogenesis of viral disease Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus Humoral immune responses against ZIKV infection and the importance of pre-existing flavivirus immunity Small animal models of Zika virus Non-Human primate models of Zika virus infection, immunity and therapeutic development Zika virus (ZIKV) infection in pregnancy: maternal, fetal and neonatal considerations Pathogenesis of other congenital viral infections Small molecules and antibodies for Zika therapy Zika virus vaccine development Zika vaccines: role for controlled human infection Clinical development strategies and considerations for Zika vaccine licensure All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Understanding the pathogenesis and natural history of Zika virus infection has been facilitated by decades of research with flaviviruses


id: cord-002754-xlk4xpv2
author: Mögling, Ramona
date: 2017-09-07
extension: .txt
mime: text/plain
words: 3941
sentence: 165
flesch: 37
cache: cache/cord-002754-xlk4xpv2.txt
txt: txt/cord-002754-xlk4xpv2.txt
title:
  Status, quality and specific needs of Zika virus (ZIKV) diagnostic capacity and capability in National Reference Laboratories for arboviruses in 30 EU/EEA countries, May 2016

summary:
  In six of the 33 laboratories that answered this question, pregnant employees were not allowed to perform ZIKV diagnostic tests. [25] ) of the two in-house tests that were most frequently used, was recommended based on in silico analysis [10] and in an independent comparative study of ZIKV molecular tests [35] , raising possible concerns about the performance of diagnostics in some laboratories.


id: cord-005301-0rl7cyqj
author: de Campos, Thana Cristina
title: Zika, public health, and the distraction of abortion
date: 2016-11-29
extension: .txt
mime: text/plain
words: 2135
sentence: 71
flesch: 43
cache: cache/cord-005301-0rl7cyqj.txt
txt: txt/cord-005301-0rl7cyqj.txt
summary:
  With abortion banned in Zika countries, women beg on web for abortion pills Planned parenthood international using Zika to fundraise for abortion advocacy Upholding women's human rights essential to Zika Zika, public health, and the distraction of abortion 445 ? Is the call for Zika virus abortions the new eugenics?


id: cord-299255-wnf8fozk
author: Chan, M.Y.
title: Infections in Pregnancy
date: 2017-11-27
extension: .txt
mime: text/plain
words: 10314
sentence: 393
flesch: 37
cache: cache/cord-299255-wnf8fozk.txt
txt: txt/cord-299255-wnf8fozk.txt
summary:
  The Centers for Disease Prevention and Control (CDC) acknowledges the link between Zika virus infection in pregnant women and subsequent birth defectsdspontaneous abortion and fetal demise Schuler-Faccini and Rasmussen, 2016) . Part 1: Herpes simplex virus infections Microbial ecology of gastrointestinal-tract Special report: Exploring the link between zika virus and microcephaly Possible association between Zika virus infection and microcephalydBrazil Main viral diseases with in utero transmission of pathogen during pregnancy, epidemiology, pathological features and outcome Main viral diseases with in utero transmission of pathogen during pregnancy: epidemiology, pathological features and outcome Congenital candidiasis: an uncommon skin eruption presenting at birth Campylobacter jejuni infection during pregnancy: long-term consequences of associated bacteremia, Guillain-BarrÃ© syndrome, and reactive arthritis Nonhuman primate model for Listeria monocytogenes-induced stillbirths Bacteria and inflammatory cells in fetal membranes do not always cause preterm labor TORCH Infections.


id: cord-003926-ycdaw2vh
author: Maslow, Joel N.
title: Zika Vaccine Development—Current Progress and Challenges for the Future
date: 2019-07-14
extension: .txt
mime: text/plain
words: 3768
sentence: 160
flesch: 39
cache: cache/cord-003926-ycdaw2vh.txt
txt: txt/cord-003926-ycdaw2vh.txt
summary:
  Expert Rev Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: Randomised, open-label, phase 1 clinical trials Safety and immunogenicity of an anti-Zika virus DNA vaccine-Preliminary Report In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunization with a prMEnv DNA vaccine Rapid development of a DNA vaccine for Zika virus Preliminary aggregate safety and immunogenicity results from three trials of a purified inactivated Zika virus vaccine candidate: Phase 1, randomised, double-blind, placebo-controlled clinical trials Vaccine protection against Zika virus from Brazil Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys Modified mRNA vaccines protect against Zika virus infection Purified inactivated Zika vaccine candidates afford protection against lethal challenge in mice A measles virus-based vaccine candidate mediates protection against Zika virus in an allogeneic mouse pregnancy model Animal models of Zika virus infection, pathogenesis, and immunity Zika virus infection during pregnancy in mice causes placental damage and fetal demise Increased hospitalizations for neuropathies as indicators of Zika virus infection, according to Health Information System data Guillain-Barré syndrome, acute disseminated encephalomyelitis and encephalitis associated with Zika virus infection in Brazil: Detection of viral RNA and Isolation of virus during late infection Ethical Considerations for Zika Virus Human Challenge Trials; National Institutes of Health Bystander risk, social value, and ethics of human research Zika vaccines: Role for controlled human infection Starting in mid-2015, Zika virus infection achieved epidemic status, spreading rapidly through South America, Central America, and the Caribbean Islands [5] .


id: cord-018632-azrqz6hf
author: Ganasegeran, Kurubaran
title: Artificial Intelligence Applications in Tracking Health Behaviors During Disease Epidemics
date: 2019-11-21
extension: .txt
mime: text/plain
words: 4314
sentence: 201
flesch: 34
cache: cache/cord-018632-azrqz6hf.txt
txt: txt/cord-018632-azrqz6hf.txt
summary:
  Based on the required functions, these concepts are clumped together to automate a single application-such as tracking infectious disease health seeking behavior. Such adaptations formed two conceptualizations: the first was Infodemiology, defined as the science of distribution and determinants of information in an electronic medium, specifically the Internet, or in a population, with the ultimate aim to inform public health and public policy [23] ; the second was Infoveillance, defined as the longitudinal tracking of infodemiology metrics for surveillance and trend analysis [24] .


id: cord-003403-ypefqm71
author: Roberts, Christine C.
title: Assay Challenges for Emerging Infectious Diseases: The Zika Experience
date: 2018-10-02
extension: .txt
mime: text/plain
words: 4960
sentence: 175
flesch: 33
cache: cache/cord-003403-ypefqm71.txt
txt: txt/cord-003403-ypefqm71.txt
summary:
  Here we review emerging infectious disease vaccine clinical assay development and trial execution with a special focus on the state of Zika virus clinical assays and diagnostics. Congenital cerebral malformations and dysfunction in fetuses and newborns following the 2013 to 2014 Zika virus epidemic in French Polynesia Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: A case study Collaborative Study to Evaluate a Candidate World Health Organization International Standard for Zika Virus for Nucleic Acid Amplification Technique (NAT)-Based Assays FDA FDA provides new tools for the development and proper evaluation of tests for detecting Zika virus infection Current status of Zika vaccine development: Zika vaccines advance into clinical evaluation Preliminary aggregate safety and immunogenicity results from three trials of a purified inactivated Zika virus vaccine candidate: Phase 1, randomised, double-blind, placebo-controlled clinical trials Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: Randomised, open-label, phase 1 clinical trials This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license


id: cord-339152-wfakzb6w
author: Trovato, Maria
title: Viral Emerging Diseases: Challenges in Developing Vaccination Strategies
date: 2020-09-03
extension: .txt
mime: text/plain
words: 12011
sentence: 328
flesch: 23
cache: cache/cord-339152-wfakzb6w.txt
txt: txt/cord-339152-wfakzb6w.txt
summary:
  United States patent US 20120141520 Advanced oxidation technology for the development of a next-generation inactivated West Nile virus vaccine Replication-defective West Nile virus with NS1 deletion as a new vaccine platform for flavivirus Zika virus associated with microcephaly A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models A vaccine based on a modified vaccinia virus Ankara vector expressing Zika virus structural proteins controls Zika virus replication in mice Construction and evaluation of novel rhesus monkey adenovirus vaccine vectors Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys Preventative vaccines for Zika virus outbreak: preliminary evaluation Recent advances in Zika virus vaccines Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials Comparison of the virulent Asibi strain of yellow fever virus with the 17D vaccine strain derived from it Live attenuated yellow fever 17D vaccine: a legacy vaccine still controlling outbreaks in modern day Development of Sanofi Pasteur tetravalent dengue vaccine From research to phase III: preclinical, industrial and clinical development of the Sanofi Pasteur tetravalent dengue vaccine Pathogenesis of dengue: challenges to molecular biology Antibody-dependent enhancement of severe dengue disease in humans Dengue: status of current and under-development vaccines Immunogenicity, safety, and tolerability of the measles-vectored chikungunya virus vaccine MV-CHIK: a double-blind, randomised, placebo-controlled and active-controlled phase 2 trial Recent progress in vaccine development against Chikungunya virus Effective vaccine for lassa fever Vaccine platforms for the prevention of Lassa fever Vaccines inducing immunity to Lassa virus glycoprotein and nucleoprotein protect macaques after a single shot Isolation of marburg-like virus from a case of haemorrhagic fever in Zaire Vaccines against Ebola virus A review of Phase I trials of Ebola virus vaccines: what can we learn from the race to develop novel vaccines Viruslike particle vaccination protects nonhuman primates from lethal aerosol exposure with marburgvirus (VLP Vaccination Protects Macaques against Aerosol Challenges) Studies for the development of a safer vaccine are still ongoing, and candidate vaccines include a tetravalent Dengue purified inactivated virus vaccine, currently in phase I/II clinical trial (NCT02421367), and two live attenuated tetravalent chimeric TDV (DENVax), and


id: cord-004418-08dljap3
author: Young, Ginger
date: 2020-02-26
extension: .txt
mime: text/plain
words: 4626
sentence: 189
flesch: 46
cache: cache/cord-004418-08dljap3.txt
txt: txt/cord-004418-08dljap3.txt
title:
  Complete Protection in Macaques Conferred by Purified Inactivated Zika Vaccine: Defining a Correlate of Protection

summary:
  PLISA Health Information Platform for the Americas: Cases of Zika virus disease Clinical Development Strategies and Considerations for Zika Vaccine Licensure Correlates of protection induced by vaccination Demonstrating vaccine effectiveness during a waning epidemic: A WHO/NIH meeting report on approaches to development and licensure of Zika vaccine candidates Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys Rapid development of a DNA vaccine for Zika virus Modified mRNA Vaccines Protect against Zika Virus Infection Comparative Pathogenesis of Asian and African-Lineage Zika Virus in Indian Rhesus Macaque's and Development of a Non-Human Primate Model Suitable for the Evaluation of New Drugs and Vaccines Nonhuman Primate Models of Zika Virus Infection, Immunity, and Therapeutic Development Macaque monkeys in Zika virus research: 1947-present Characterization of a 2016 Clinical Isolate of Zika Virus in Non-human Heterologous Protection against Asian Zika Virus Challenge in Rhesus Macaques A rhesus macaque model of Asian-lineage Zika virus infection Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues Purified Inactivated Zika Vaccine Candidates Afford Protection against Lethal Challenge in Mice Protective efficacy of Zika vaccine in AG129 mouse model Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine Vaccine protection against Zika virus from Brazil Durability and correlates of vaccine protection against Zika virus in rhesus monkeys Passive Transfer of Immune Sera Induced by a Zika Virus-Like Particle Vaccine Protects AG129 Mice Against Lethal Zika Virus Challenge Report on a WHO consultation on immunological endpoints for evaluation of new Japanese encephalitis vaccines Yellow fever vaccine: direct challenge of monkeys given graded doses of 17D vaccine Neutralizing antibodies protect against lethal flavivirus challenge but allow for the development of active humoral immunity to a nonstructural virus protein Preliminary aggregate safety and immunogenicity results from three trials of a purified inactivated Zika virus vaccine candidate: phase 1, randomised, double-blind, placebo-controlled clinical trials A 'Furry-Tale' of Zika Virus Infection: What Have We Learned from Animal Models? In this study we evaluated the antibody responses and efficacy of an aluminum hydroxide adjuvanted purified inactivated Zika vaccine (PIZV) against challenge with Zika virus (ZIKV) strain PRVABC59.


id: cord-293871-hzes7mwt
author: McGuinness, Sarah L.
title: Pretravel Considerations for Non-vaccine-Preventable Travel Infections
date: 2018-11-26
extension: .txt
mime: text/plain
words: 4023
sentence: 170
flesch: 38
cache: cache/cord-293871-hzes7mwt.txt
txt: txt/cord-293871-hzes7mwt.txt
summary:
  41 Long-term sequelae of chikungunya virus disease: a systematic review Zika: the origin and spread of a mosquito-borne virus Zika virus: history of a newly emerging arbovirus Zika virus outbreak on Yap Island, Federated States of Micronesia Zika virus Epidemiology, prevention, and potential future treatments of sexually transmitted Zika virus infection Zika virus classification tables Fatal Zika virus infection with secondary nonsexual transmission Estimated incubation period for Zika virus disease Persistence of Zika virus in body fluids-preliminary report Congenital Zika virus infection beyond neonatal microcephaly Update: interim guidance for health care providers caring for pregnant women with possible Zika virus exposure-United States (including US territories) World Health Organization. 28 Pregnant women possibly exposed to ZIKV due to travel or sexual contact should discuss the potential exposure with their Although no vaccines are available at this time for prevention of MERS and avian influenza (H5N1 and H7N9) in travelers, providers should routinely review the most recent epidemiology of severe respiratory infections reported by authorities such as the WHO and CDC (see Table 7 .1) and promote general hygiene and other preventative measures to travelers to these areas (Box 7.2).


id: cord-322206-roxa3ix6
author: I. Sardi, Silvia
date: 2020-07-21
extension: .txt
mime: text/plain
words: 4203
sentence: 157
flesch: 39
cache: cache/cord-322206-roxa3ix6.txt
txt: txt/cord-322206-roxa3ix6.txt
title:
  High-Quality Resolution of the Outbreak-Related Zika Virus Genome and Discovery of New Viruses Using Ion Torrent-Based Metatranscriptomics

summary:
  Virome of > 12 thousand Culex mosquitoes from throughout California Southern tomato virus: The link between the families Totiviridae and Partitiviridae Expanding our Understanding of the Seaweed Holobiont: RNA Viruses of the Red Alga Delisea pulchra This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license We thank all the members of Virology and Allergy and Acarology laboratories. Due to their worldwide occurrence and fast adaptation to environmental changes, mosquitoes from the Aedes genus play an important role in the transmission of viral etiological agents of emerging human infections, including Dengue virus (DENV), Zika virus (ZIKV), Chikungunya virus (CHYKV) and 2 of 10 Yellow fever virus (YFV)


id: cord-319691-yrt8fq9m
author: Pinchoff, Jessie
date: 2019-09-23
extension: .txt
mime: text/plain
words: 8318
sentence: 320
flesch: 34
cache: cache/cord-319691-yrt8fq9m.txt
txt: txt/cord-319691-yrt8fq9m.txt
title:
  Evidence-Based Process for Prioritizing Positive Behaviors for Promotion: Zika Prevention in Latin America and the Caribbean and Applicability to Future Health Emergency Responses

summary:
  [8] [9] When too many preventive behaviors are promoted or messages lack precision, adopting prevention behaviors can be inhibited or done in a way that is either ineffective or counterproductive. In a non-systematic, rapid desk review of SBC messages approximately 1 year after the USAID Zika response began, we identified more than 30 variants of prevention behaviors that were being promoted.


id: cord-002341-v4r5d26a
author: Chan, Jasper Fuk-Woo
date: 2016-11-12
extension: .txt
mime: text/plain
words: 7158
sentence: 242
flesch: 40
cache: cache/cord-002341-v4r5d26a.txt
txt: txt/cord-002341-v4r5d26a.txt
title:
  Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons

summary:
  Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys Characterization of lethal Zika virus infection in AG129 mice Fatal sickle cell disease and Zika virus infection in girl from Colombia Zika virus infection of the central nervous system of mice Acute glomerulonephritis in dengue haemorrhagic fever in the absence of shock, sepsis, haemolysis or rhabdomyolysis Isolation of infective Zika virus from urine and saliva of patients in Brazil Comparative analysis between Flaviviruses reveals specific neural stem cell tropism for Zika virus in the mouse developing Neocortex Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study Guillain-Barre syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study Zika virus associated with Meningoencephalitis Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Development and evaluation of novel realtime reverse transcription-PCR assays with locked nucleic acid probes targeting leader sequences of human-pathogenic coronaviruses Treatment with Lopinavir/ritonavir or interferon-beta1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Zika fever and congenital Zika syndrome: an unexpected emerging arboviral disease Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs An observational study of dengue fever in a tertiary care hospital of eastern India The Brazilian Zika virus strain causes birth defects in experimental models Ocular findings in infants with microcephaly associated with presumed Zika virus congenital infection in Salvador, Brazil Zika virus. In addition to the reported findings of detectable virus particles and/or RNA in the brain, spinal cord, kidney, spleen, liver, testis, ovary, heart, lung, muscle, and blood of types I/II interferon-signaling-/receptor-deficient mice with ZIKV infection, our study identified intestine, pancreas, and salivary gland as other possible tissues and anatomical sites for virus infection (Dick, 1952; Lazear et al., 2016; Dowall et al., 2016; Aliota et al., 2016; Rossi et al., 2016) .


id: cord-262944-9k64f0tw
author: Parker, Elaine L.
title: Viral-Immune Cell Interactions at the Maternal-Fetal Interface in Human Pregnancy
date: 2020-10-07
extension: .txt
mime: text/plain
words: 9825
sentence: 313
flesch: 32
cache: cache/cord-262944-9k64f0tw.txt
txt: txt/cord-262944-9k64f0tw.txt
summary:
  This also demonstrates that dNK cells are able to localize and target HCMV infected cells while sparing fetal derived semiallogenic trophoblast cells (80) . This study proved, through antibody mediated abrogation of the Fas ligand (FasL) and tumor necrosis factor-related apoptosis-induced ligand (TRAIL) on dNK cells, that death of HCMV infected cells is not initiated by dNK cells through these death receptor-ligand pathways.


id: cord-257539-01s21vh0
author: Delvecchio, Rodrigo
title: Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models
date: 2016-11-29
extension: .txt
mime: text/plain
words: 5676
sentence: 226
flesch: 47
cache: cache/cord-257539-01s21vh0.txt
txt: txt/cord-257539-01s21vh0.txt
summary:
  A case study Zika virus impairs growth in human neurospheres and brain organoids Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth Zika virus outbreak on Yap Island, Federated States of Micronesia Zika virus infection experimentally induced in a human volunteer Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: A case-control study Leparc-Goffart, I. Evidence of Sexual Transmission of Zika Virus Male-to-Male Sexual Transmission of Zika Virus -Texas Hydroxychloroquine and Chloroquine Retinopathy Pregnancy Outcome Following First Trimester Exposure to Chloroquine Inhibition of human immunodeficiency virus infectivity by chloroquine In vitro inhibition of human influenza We demonstrate that chloroquine reduces the number of ZIKV-infected cells in vitro, and inhibits virus production and cell death promoted by ZIKV infection without cytotoxic effects.


id: cord-003482-f1uvohf0
author: Malmlov, Ashley
date: 2019-02-04
extension: .txt
mime: text/plain
words: 7514
sentence: 364
flesch: 51
cache: cache/cord-003482-f1uvohf0.txt
txt: txt/cord-003482-f1uvohf0.txt
title:
  Experimental Zika virus infection of Jamaican fruit bats (Artibeus jamaicensis) and possible entry of virus into brain via activated microglial cells

summary:
  Isolation and haemagglutination-inhibition studies on bats collected in Kenya and throughout Uganda Effect of Zika virus and Bwamba virus in the cave bat (Myotis lucifugus) Transmission studies of Hendra virus (equine morbillivirus) in the fruit bats, horses and cats Pteropid bats are confirmed as the reservoir hosts of henipaviruses: A comprehensive experimental study of virus transmission Antibody-mediated immune response in the bat, Pteropus giganteus Detection of specfic antibody responses to vaccinatin in variable flying foxes (Pteropus hypomelanus) The little brown bat, M. lucifugus, displays a highly diverse VH, DH, JH repertoire but little evidence of somatic hypermutation Tacaribe virus cases fatal infection of an ostensible reservoir host, the Jamaican fruit bat Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis) Transcriptomic signatures of tacaribe virus-infected Jamaican fruit bats Assay optimization for molecular detection of Zika virus A rhesus macaque model of Asian-lineage Zika virus infection Zika virus testing considerations: lessons learned from the first eighty real-time RT-PCR-positive cases diagnosed in New York State Detection of Zika virus in urine Long-term kinetics of Zika virus RNA and antibodies in body fluids of a vasectomized traveller returning from Martinique: a case report Persistence of Zika virus in body fluids-Preliminary report Zika virus causes testis damage and leads to male infertility in mice Zika virus infection damages the testes in mice A mouse model of Zika virus pathogenesis Zika viral infection and neutralizing human antibody response in a BLT humanized mouse model Notes from the field: Evidence of Zika virus infection in brain and placental tissues from two congenitally infected newborns and two fetal losses-Brazil Zika virus damages the human placental barrier and presents marked fetal neurotropism Pathology of congenital Zika syndrome in Brazil: a case series Zika virus infection of rhesus macaques leads to viral persistence in multiple tissues Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate Nonhuman primate models of Zika virus infection, immunity, and therapeutic development Zika viral dynamics and shedding in rhesus and cynomolgus macaques Overview of the current status of Zika virus pathogenesis and animal related research Axl mediates Zika virus entry in human glial cells and modulates innate immune responses Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity Entry sites of Venezuelan and western equine encephalitis viruses in the mouse central nervous system following peripheral infection Detection of Zika virus in saliva Biology of Zika virus infection in human skin cells Denge virus in Mexican bats Neotropical bats that co-habit with humans function as dead-end hosts for dengue virus Detection of dengue virus neutralizing antibodies in bats from Costa Rica and Ecuador Sylvatic transmission of arboviruses among bornean orangutans Zika virus, vectors, reservoirs, amplifying hosts, and their potential to spread worldwide: what we know and what we should investigate urgently A sero-epidemiological survey for certain arboviruses (Togaviridae) in Pakistan Investigating the potential role of North American animals as hosts for Zika virus. Distribution of viral antigen in bat tissues suggests that infection in this species recapitulates human infection, which is thought to start with infection of epidermal and dermal cells with subsequent dissemination to multiple organs including salivary glands as viral RNA can be detected in human saliva [44, 45] .


id: cord-003041-v9uevz3l
author: Zukor, Katherine
date: 2018-02-23
extension: .txt
mime: text/plain
words: 8927
sentence: 315
flesch: 42
cache: cache/cord-003041-v9uevz3l.txt
txt: txt/cord-003041-v9uevz3l.txt
title:
  Zika virus-induced acute myelitis and motor deficits in adult interferon αβ/γ receptor knockout mice

summary:
  While ZIKV infection of adults generally produces only a mild disease, it is becoming apparent that, as with other flavivirus infections, severe neurological sequelae can occur. Given the emerging nature of ZIKV, however, it is likely that we do not fully understand the acute and long-term consequences of ZIKV infection on the nervous system.


id: cord-004020-qtwcbn7m
author: Gao, Yaning
title: Identification of Novel Natural Products as Effective and Broad-Spectrum Anti-Zika Virus Inhibitors
date: 2019-11-02
extension: .txt
mime: text/plain
words: 7718
sentence: 257
flesch: 42
cache: cache/cord-004020-qtwcbn7m.txt
txt: txt/cord-004020-qtwcbn7m.txt
summary:
  Anti-ZIKV compounds, such as temoporfin [28] , 25-hydroxycholesterol [29] , bortezomib [16] , and NITD008 No therapeutic agents have, so far, been approved for the treatment of ZIKV infection in humans; as such, there is a need for a continuous effort to develop effective and safe antiviral drugs to treat ZIKV-caused diseases.


id: cord-002602-2qvyhjlp
author: Roy, Amrita
date: 2017-07-10
extension: .txt
mime: text/plain
words: 9013
sentence: 329
flesch: 49
cache: cache/cord-002602-2qvyhjlp.txt
txt: txt/cord-002602-2qvyhjlp.txt
title:
  Solution conformations of Zika NS2B-NS3pro and its inhibition by natural products from edible plants

summary:
  On the other hand, our results suggest that despite being intrinsically disordered [44] , the C-half of Zika NS2B is absolutely required for implementing the catalytic actions, thus implying that the closed conformation might be enzymatically-active, which was also previously speculated [27] Unfortunately, NMR spectroscopy cannot be utilized to investigate the interaction between those compounds and Zika NS2B-NS3pro as the presence of 20% glycerol significantly increased the rotational tumbling time of the protein which made NMR peaks too broad for detection.


id: cord-002581-r7mskri0
author: Magnani, Diogo M.
title: A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus
date: 2017-06-12
extension: .txt
mime: text/plain
words: 5299
sentence: 240
flesch: 50
cache: cache/cord-002581-r7mskri0.txt
txt: txt/cord-002581-r7mskri0.txt
summary:
  Ultrasound Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise Possible Association Between Zika Virus Infection and Microcephaly-Brazil Interim Guidelines for the Evaluation and Testing of Infants with Possible Congenital Zika Virus Infection-United States Interim Guidelines for Pregnant Women During a Zika Virus Outbreak-United States Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning IgBLAST: an immunoglobulin variable domain sequence analysis tool IMGT/V-QUEST: Zika virus (ZIKV) belongs to the genus Flavivirus of the Flaviviridae family and is related to dengue virus (DENV), yellow fever virus (YFV), Japanese encephalitis virus (JEV), and west Nile virus (WNV)


id: cord-278286-1xk31726
author: Mutso, Margit
title: Basic insights into Zika virus infection of neuroglial and brain endothelial cells
date: 2020-04-30
extension: .txt
mime: text/plain
words: 6026
sentence: 262
flesch: 50
cache: cache/cord-278286-1xk31726.txt
txt: txt/cord-278286-1xk31726.txt
summary:
  Mouse and human OECs and hCMEC/D3 cells were infected as described above. Therefore, infected hOEC and hCMEC/D3 cells were harvested at 16 h p.i.; at this time point only primarily infected cells had detectable expression of NS3.


id: cord-010119-t1x9gknd
title: Abstract Presentations from the AABB Annual Meeting San Diego, CA ctober 7‐10, 2017
date: 2017-09-04
extension: .txt
mime: text/plain
words: 230433
sentence: 10311
flesch: 50
cache: cache/cord-010119-t1x9gknd.txt
txt: txt/cord-010119-t1x9gknd.txt
summary:
  Probability of occurrence of cannabis metabolites in blood donor samples is likely to be highly variable across donor centers and is largely dependent on blood donor demographics. OBRR, CBER, FDA Background/Case Studies: Extended molecular typing of a large number of blood donors can increase the likelihood of identifying donor red blood cells (RBCs) that match those of the recipient.


# url

id: cord-288703-wdh1jiry
domain: scroll.in
url:
  https://scroll.in/pulse/843567/india-is-expandingzika-surveillance-but-there-was-an-element-of-luckin-finding-the-tamil-nadu-case


# ent

id: cord-005885-r3qtoqu1
sid: 29
eid: 1
type: ORG
entity:
  der zusammenhang zwischen pränataler zika-virus-übertragung und embryopathien wie neuralrohrdefekten und mikrozephalie wurde


id: cord-005885-r3qtoqu1
sid: 55
eid: 12
type: PERSON
entity:
  cme zeichen einer durchgemachten anderen flavivirusinfektion oder der gelbfieberimpfung sein können.


id: cord-005885-r3qtoqu1
sid: 74
eid: 3
type: ORG
entity:
  der fälle auftretende makulopapulöse exanthem zentripetal aus und kann auch eine palmoplantare beteiligung bieten [


id: cord-319691-yrt8fq9m
sid: 266
eid: 4
type: ORG
entity:
  futuras respuestas de emergencia de salud pública en el propósito de maximizar el impacto de los esfuerzos de prevención


