# bib

id: cord-002247-e0z5ypii
author: Squires, Raynal C
title: Preparedness for Zika virus testing in the World Health Organization Western Pacific Region
date: 2016-03-31
extension: .txt
mime: text/plain
words: 1571
sentence: 55
flesch: 32
cache: cache/cord-002247-e0z5ypii.txt
txt: txt/cord-002247-e0z5ypii.txt
summary:
  A total of 28 surveys to national-level laboratories likely to be tasked with ZIKV testing were distributed to 19 countries in the Region (omitting resource-limited countries with Zika virus testing preparedness in the Western Pacific Region Squires & Konings reporting having this capacity. key: cord-002247-e0z5ypii authors: Squires, Raynal C; Konings, Frank title: Preparedness for Zika virus testing in the World Health Organization Western Pacific Region date: 2016-03-31 journal:


id: cord-102796-rr8qet8c
author: Counotte, Michel J
title: Emergence of evidence during disease outbreaks: lessons learnt from the Zika virus outbreak
date: 2020-03-18
extension: .txt
mime: text/plain
words: 3047
sentence: 167
flesch: 53
cache: cache/cord-102796-rr8qet8c.txt
txt: txt/cord-102796-rr8qet8c.txt
summary:
  In the 2013-2016 ZIKV outbreak, case reports, case series and basic research studies were published first. For basic research studies, many of which were done in countries unaffected by 85 ZIKV, we assigned the time to publication as the time between 1 February 2016 (the PHEIC declaration) 86 and the first available publication date.


id: cord-102279-ena1usqv
author: Long, Rory K. M.
date: 2020-06-23
extension: .txt
mime: text/plain
words: 3688
sentence: 156
flesch: 45
cache: cache/cord-102279-ena1usqv.txt
txt: txt/cord-102279-ena1usqv.txt
title:
  Super Resolution Microscopy and Deep Learning Identify Zika Virus Reorganization of the Endoplasmic Reticulum

summary:
  Graphs show quantification of volume percent of NS4B, NS2B and dsRNA ER regions relative to total ER, CER or PER. 3D voxel-based visu-137 alization and quantification showed that the density of ER tubular structures in the dsRNA-positive 138 ER is higher, for both the ERmoxGFP or Sec61β-GFP ER reporters, than in the dsRNA-negative CER 139 regions of ZIKV-infected cells or the CER of mock-infected cells ( Figure 3B ).


id: cord-002754-xlk4xpv2
author: Mögling, Ramona
date: 2017-09-07
extension: .txt
mime: text/plain
words: 3941
sentence: 165
flesch: 37
cache: cache/cord-002754-xlk4xpv2.txt
txt: txt/cord-002754-xlk4xpv2.txt
title:
  Status, quality and specific needs of Zika virus (ZIKV) diagnostic capacity and capability in National Reference Laboratories for arboviruses in 30 EU/EEA countries, May 2016

summary:
  In six of the 33 laboratories that answered this question, pregnant employees were not allowed to perform ZIKV diagnostic tests. [25] ) of the two in-house tests that were most frequently used, was recommended based on in silico analysis [10] and in an independent comparative study of ZIKV molecular tests [35] , raising possible concerns about the performance of diagnostics in some laboratories.


id: cord-284646-fhruiw23
author: Jaeger, Anna S.
date: 2020-05-24
extension: .txt
mime: text/plain
words: 3954
sentence: 128
flesch: 42
cache: cache/cord-284646-fhruiw23.txt
txt: txt/cord-284646-fhruiw23.txt
title:
  Spondweni virus causes fetal harm in Ifnar1(-/-) mice and is transmitted by Aedes aegypti mosquitoes

summary:
  An 783 account of theRockefeller Foundation virus program Zika virus and the nonmicrocephalic fetus: why we should still worry Emerg 790 Spondweni virus infection in a 792 foreign resident of Upper Volta The incidence of arthropod-794 borne viruses in a population of culicine mosquitoes in Tongaland Type I interferons instigate fetal demise after Zika virus infection. key: cord-284646-fhruiw23 authors: Jaeger, Anna S.; Weiler, Andrea M.; Moriarty, Ryan V.; Rybarczyk, Sierra; O'Connor, Shelby L.; O'Connor, David H.; Seelig, Davis M.; Fritsch, Michael K.; Friedrich, Thomas C.; Aliota, Matthew T. title: Spondweni virus causes fetal harm in Ifnar1(-/-) mice and is transmitted by Aedes aegypti mosquitoes date: 2020-05-24 journal: Virology DOI: 10.1016/j.virol.2020.05.005 sha: doc_id: 284646 cord_uid: fhruiw23 Spondweni virus (SPONV) is the most closely related known flavivirus to Zika virus (ZIKV).


id: cord-003453-p2buyrcj
author: Batista, Mariana N.
title: Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika Virus
date: 2019-01-11
extension: .txt
mime: text/plain
words: 4166
sentence: 167
flesch: 43
cache: cache/cord-003453-p2buyrcj.txt
txt: txt/cord-003453-p2buyrcj.txt
summary:
  In previous studies, the effect of emodin on virus entry was Berberine and emodin, when evaluated in vitro, have virucidal effects on Zika virus. Dynamic light scattering data showed that both compounds significantly reduce the hydrodynamic radius of virus particle in solution.


id: cord-272405-jmwn8pdn
author: Parvez, Mohammad K.
title: Evolution and Emergence of Pathogenic Viruses: Past, Present, and Future
date: 2017-08-04
extension: .txt
mime: text/plain
words: 4198
sentence: 163
flesch: 37
cache: cache/cord-272405-jmwn8pdn.txt
txt: txt/cord-272405-jmwn8pdn.txt
summary:
  The established natural reservoirs of human viruses are mainly farm animals, and, to a lesser extent, wild animals and arthropods. The established natural reservoirs of human viruses are mainly farm animals, and, to a lesser extent, wild animals and arthropods.


id: cord-004418-08dljap3
author: Young, Ginger
date: 2020-02-26
extension: .txt
mime: text/plain
words: 4626
sentence: 189
flesch: 46
cache: cache/cord-004418-08dljap3.txt
txt: txt/cord-004418-08dljap3.txt
title:
  Complete Protection in Macaques Conferred by Purified Inactivated Zika Vaccine: Defining a Correlate of Protection

summary:
  PLISA Health Information Platform for the Americas: Cases of Zika virus disease Clinical Development Strategies and Considerations for Zika Vaccine Licensure Correlates of protection induced by vaccination Demonstrating vaccine effectiveness during a waning epidemic: A WHO/NIH meeting report on approaches to development and licensure of Zika vaccine candidates Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys Rapid development of a DNA vaccine for Zika virus Modified mRNA Vaccines Protect against Zika Virus Infection Comparative Pathogenesis of Asian and African-Lineage Zika Virus in Indian Rhesus Macaque's and Development of a Non-Human Primate Model Suitable for the Evaluation of New Drugs and Vaccines Nonhuman Primate Models of Zika Virus Infection, Immunity, and Therapeutic Development Macaque monkeys in Zika virus research: 1947-present Characterization of a 2016 Clinical Isolate of Zika Virus in Non-human Heterologous Protection against Asian Zika Virus Challenge in Rhesus Macaques A rhesus macaque model of Asian-lineage Zika virus infection Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues Purified Inactivated Zika Vaccine Candidates Afford Protection against Lethal Challenge in Mice Protective efficacy of Zika vaccine in AG129 mouse model Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine Vaccine protection against Zika virus from Brazil Durability and correlates of vaccine protection against Zika virus in rhesus monkeys Passive Transfer of Immune Sera Induced by a Zika Virus-Like Particle Vaccine Protects AG129 Mice Against Lethal Zika Virus Challenge Report on a WHO consultation on immunological endpoints for evaluation of new Japanese encephalitis vaccines Yellow fever vaccine: direct challenge of monkeys given graded doses of 17D vaccine Neutralizing antibodies protect against lethal flavivirus challenge but allow for the development of active humoral immunity to a nonstructural virus protein Preliminary aggregate safety and immunogenicity results from three trials of a purified inactivated Zika virus vaccine candidate: phase 1, randomised, double-blind, placebo-controlled clinical trials A 'Furry-Tale' of Zika Virus Infection: What Have We Learned from Animal Models? In this study we evaluated the antibody responses and efficacy of an aluminum hydroxide adjuvanted purified inactivated Zika vaccine (PIZV) against challenge with Zika virus (ZIKV) strain PRVABC59.


id: cord-002720-lrkscs71
author: Kurosaki, Yohei
date: 2017-10-18
extension: .txt
mime: text/plain
words: 4956
sentence: 177
flesch: 46
cache: cache/cord-002720-lrkscs71.txt
txt: txt/cord-002720-lrkscs71.txt
title:
  Development and evaluation of a rapid molecular diagnostic test for Zika virus infection by reverse transcription loop-mediated isothermal amplification

summary:
  Zika virus: history of a newly emerging arbovirus Zika Virus Outbreak, Bahia, Brazil Zika Virus Associated with Microcephaly Possible Association Between Zika Virus Infection and Microcephaly -Brazil Association between Zika virus infection and microcephaly in Brazil Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation Probable transfusion-transmitted Zika virus in Brazil Transmission of Zika Virus Through Sexual Contact with Travelers to Areas of Ongoing Transmission -Continental United States Sexually acquired Zika virus: a systematic review Molecular evolution of Zika virus during its emergence in the 20(th) century Zika Virus Transmission from French Polynesia to Brazil Zika virus in the Americas: Early epidemiological and genetic findings Detection of Zika virus in urine Detection of Zika virus in saliva Comparison of Test Results for Zika Virus RNA in Urine, Serum, and Saliva Specimens from Persons with Travel-Associated Zika Virus Disease -Florida Persistence of Zika Virus in Body Fluids -Preliminary Report Zika Virus Testing Considerations: Lessons Learned from the First 80 Real-Time Reverse Transcription-PCR-Positive Cases Diagnosed in New York State Viral load kinetics of Zika virus in plasma, urine and saliva in a couple returning from Martinique, French West Indies Quantitative real-time PCR detection of Zika virus and evaluation with field-caught mosquitoes Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia Zika Virus: Diagnostics for an Emerging Pandemic Threat Prolonged detection of Zika virus RNA in urine samples during the ongoing Zika virus epidemic in Brazil Rapid Molecular Detection of Zika Virus in Acute-Phase Urine Samples Using the Recombinase Polymerase Amplification Assay First case of laboratory-confirmed Zika virus infection imported into Europe Cross reactivity of commercial anti-dengue immunoassays in patients with acute Zika virus infection Loop-mediated isothermal amplification of DNA Development and evaluation of a novel loop-mediated isothermal amplification method for rapid detection of severe acute respiratory syndrome coronavirus Loop-mediated isothermal amplification (LAMP): principle, features, and future prospects Deployment of a Reverse Transcription Loop-Mediated Isothermal Amplification Test for Ebola Virus Surveillance in Remote Areas in Guinea Development and Evaluation of Reverse Transcription-Loop-Mediated Isothermal Amplification (RT-LAMP) key: cord-002720-lrkscs71 authors: Kurosaki, Yohei; Martins, Danyelly Bruneska Gondim; Kimura, Mayuko; Catena, Andriu dos Santos; Borba, Maria Amélia Carlos Souto Maior; Mattos, Sandra da Silva; Abe, Haruka; Yoshikawa, Rokusuke; de Lima Filho, José Luiz; Yasuda, Jiro title: Development and evaluation of a rapid molecular diagnostic test for Zika virus infection by reverse transcription loop-mediated isothermal amplification date: 2017-10-18 journal: Sci Rep DOI: 10.1038/s41598-017-13836-9 sha: doc_id: 2720 cord_uid: lrkscs71 The recent outbreak of Zika virus (ZIKV) disease caused an enormous number of infections in Central and South America, and the unusual increase in the number of infants born with microcephaly associated with ZIKV infection aroused global concern.


id: cord-253616-7jyui5ca
author: Lai, Zheng-Zong
title: Harringtonine Inhibits Zika Virus Infection through Multiple Mechanisms
date: 2020-09-07
extension: .txt
mime: text/plain
words: 4986
sentence: 216
flesch: 43
cache: cache/cord-253616-7jyui5ca.txt
txt: txt/cord-253616-7jyui5ca.txt
summary:
  Substantial research on screening antiviral agents against ZIKV and preventing ZIKV infection are globally underway, but Food and Drug Administration (FDA)-approved treatments are not available yet. Results of IFA assay also showed that harringtonine treatment inhibited ZIKV infection in a dose-dependent manner ( Figure 1E ,F).


id: cord-102612-xx5l8r9e
author: Kodani, Andrew
title: Zika virus alters centrosome organization to suppress the innate immune response
date: 2020-09-15
extension: .txt
mime: text/plain
words: 4919
sentence: 204
flesch: 38
cache: cache/cord-102612-xx5l8r9e.txt
txt: txt/cord-102612-xx5l8r9e.txt
summary:
  As ZIKV infection causes CEP63 to overaccumulate at centrosomes, we determined whether ZIKV NS3 interacts with CEP63. Immunoprecipitation of endogenous CEP63 in ZIKV-infected cells revealed that CEP63 interacts with ZIKV NS3 (Figure 3B ). To confirm the interaction of ZIKV NS3 with CEP63, we transfected cells with Myc-tagged Brazilian ZIKV NS3 and found that Myc-NS3 co-precipitated with endogenous CEP63, but not CP110, another centrosomal protein that misaccumulates at the centrosome upon ZIKV infection ( Figure 3C ).


id: cord-004022-cr0zskcw
author: Lu, Chien-Yi
date: 2019-10-31
extension: .txt
mime: text/plain
words: 5559
sentence: 180
flesch: 41
cache: cache/cord-004022-cr0zskcw.txt
txt: txt/cord-004022-cr0zskcw.txt
title:
  The Rescue and Characterization of Recombinant, Microcephaly-Associated Zika Viruses as Single-Round Infectious Particles

summary:
  The DNA-launched replicon of ZIKV Natal RGN was constructed and contains the EGFP reporter, lacks prM-E genes, and replicates under CMV promoter control. Moreover, ZIKV Natal RGN SRIPs effectively self-replicated in rhabdomyosarcoma/muscle, glioblastoma/astrocytoma, and retinal pigmented epithelial cells, displaying unique cell susceptibility with differential attachment activity.


id: cord-002581-r7mskri0
author: Magnani, Diogo M.
title: A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus
date: 2017-06-12
extension: .txt
mime: text/plain
words: 5299
sentence: 240
flesch: 50
cache: cache/cord-002581-r7mskri0.txt
txt: txt/cord-002581-r7mskri0.txt
summary:
  Ultrasound Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise Possible Association Between Zika Virus Infection and Microcephaly-Brazil Interim Guidelines for the Evaluation and Testing of Infants with Possible Congenital Zika Virus Infection-United States Interim Guidelines for Pregnant Women During a Zika Virus Outbreak-United States Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning IgBLAST: an immunoglobulin variable domain sequence analysis tool IMGT/V-QUEST: Zika virus (ZIKV) belongs to the genus Flavivirus of the Flaviviridae family and is related to dengue virus (DENV), yellow fever virus (YFV), Japanese encephalitis virus (JEV), and west Nile virus (WNV)


id: cord-009399-6zpkpdzu
author: Sun, Fang
title: Topology, Antiviral Functional Residues and Mechanism of IFITM1
date: 2020-03-08
extension: .txt
mime: text/plain
words: 5761
sentence: 277
flesch: 53
cache: cache/cord-009399-6zpkpdzu.txt
txt: txt/cord-009399-6zpkpdzu.txt
summary:
  To determine the detailed topological model that IFITM1 adopted on the cell membranes, we constructed pcDNA3.1-HA-IFITM1-Myc plasmid to express IFITM1 protein fused N-terminal HA-tag and C-terminal Myc-tag for the experiments. To determine the detailed topological model that IFITM1 adopted on the cell membranes, we constructed pcDNA3.1-HA-IFITM1-Myc plasmid to express IFITM1 protein fused N-terminal HA-tag and C-terminal Myc-tag for the experiments.


id: cord-003403-ypefqm71
author: Roberts, Christine C.
title: Assay Challenges for Emerging Infectious Diseases: The Zika Experience
date: 2018-10-02
extension: .txt
mime: text/plain
words: 4960
sentence: 175
flesch: 33
cache: cache/cord-003403-ypefqm71.txt
txt: txt/cord-003403-ypefqm71.txt
summary:
  Here we review emerging infectious disease vaccine clinical assay development and trial execution with a special focus on the state of Zika virus clinical assays and diagnostics. Congenital cerebral malformations and dysfunction in fetuses and newborns following the 2013 to 2014 Zika virus epidemic in French Polynesia Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: A case study Collaborative Study to Evaluate a Candidate World Health Organization International Standard for Zika Virus for Nucleic Acid Amplification Technique (NAT)-Based Assays FDA FDA provides new tools for the development and proper evaluation of tests for detecting Zika virus infection Current status of Zika vaccine development: Zika vaccines advance into clinical evaluation Preliminary aggregate safety and immunogenicity results from three trials of a purified inactivated Zika virus vaccine candidate: Phase 1, randomised, double-blind, placebo-controlled clinical trials Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: Randomised, open-label, phase 1 clinical trials This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license


id: cord-016796-g4kqqpy1
author: Bramhachari, Pallaval Veera
date: 2019-11-05
extension: .txt
mime: text/plain
words: 5647
sentence: 199
flesch: 24
cache: cache/cord-016796-g4kqqpy1.txt
txt: txt/cord-016796-g4kqqpy1.txt
title:
  Advanced Immunotechnological Methods for Detection and Diagnosis of Viral Infections: Current Applications and Future Challenges

summary:
  Immunofluorescence assay is extensively used for rapid identification of virus infections through detection of virus antigen or virus-specific antibodies in clinical specimens. AuNP-based detection techniques were reported by various groups of clinically relevant viruses with a unique focus on applied types of bio-AuNP hybrid structures, virus detection targets, and assay modalities and formats were recently developed (Draz and Shafiee 2018).


id: cord-257539-01s21vh0
author: Delvecchio, Rodrigo
title: Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models
date: 2016-11-29
extension: .txt
mime: text/plain
words: 5676
sentence: 226
flesch: 47
cache: cache/cord-257539-01s21vh0.txt
txt: txt/cord-257539-01s21vh0.txt
summary:
  A case study Zika virus impairs growth in human neurospheres and brain organoids Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth Zika virus outbreak on Yap Island, Federated States of Micronesia Zika virus infection experimentally induced in a human volunteer Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: A case-control study Leparc-Goffart, I. Evidence of Sexual Transmission of Zika Virus Male-to-Male Sexual Transmission of Zika Virus -Texas Hydroxychloroquine and Chloroquine Retinopathy Pregnancy Outcome Following First Trimester Exposure to Chloroquine Inhibition of human immunodeficiency virus infectivity by chloroquine In vitro inhibition of human influenza We demonstrate that chloroquine reduces the number of ZIKV-infected cells in vitro, and inhibits virus production and cell death promoted by ZIKV infection without cytotoxic effects.


id: cord-278286-1xk31726
author: Mutso, Margit
title: Basic insights into Zika virus infection of neuroglial and brain endothelial cells
date: 2020-04-30
extension: .txt
mime: text/plain
words: 6026
sentence: 262
flesch: 50
cache: cache/cord-278286-1xk31726.txt
txt: txt/cord-278286-1xk31726.txt
summary:
  Mouse and human OECs and hCMEC/D3 cells were infected as described above. Therefore, infected hOEC and hCMEC/D3 cells were harvested at 16 h p.i.; at this time point only primarily infected cells had detectable expression of NS3.


id: cord-273065-peqz7okh
author: Girard, Marc
title: Arboviruses: A global public health threat
date: 2020-04-24
extension: .txt
mime: text/plain
words: 5575
sentence: 212
flesch: 45
cache: cache/cord-273065-peqz7okh.txt
txt: txt/cord-273065-peqz7okh.txt
summary:
  Nevertheless, the substantial public health benefits of even a moderately effective dengue vaccine continue to drive all the efforts at developing dengue vaccines [29, 30] , hoping that safety concerns may be adequately addressed. Dr Joao Bosco Siqueira reported that Brazil had suffered from a shortage of yellow fever vaccine.


id: cord-002164-oqc9h2lu
author: Kumar, Ashutosh
date: 2016-08-09
extension: .txt
mime: text/plain
words: 5811
sentence: 147
flesch: 23
cache: cache/cord-002164-oqc9h2lu.txt
txt: txt/cord-002164-oqc9h2lu.txt
title:
  A Possible Mechanism of Zika Virus Associated Microcephaly: Imperative Role of Retinoic Acid Response Element (RARE) Consensus Sequence Repeats in the Viral Genome

summary:
  Retinoic acid is a non-peptide small lipophilic molecule derived from retinol-an active ingredient of vitamin A. Retinol gets converted to retinal and further into retinoic acid by the action of dehydrogenases which includes CYP1B1. The number of RARE consensus sequences repeats in the checked 17 strains of the ZIKV and other ZIKV viruses are provided in Tables 2, 3 respectively.


id: cord-004053-nmt221tu
author: Goh, Gerard Kian-Meng
title: Zika and Flavivirus Shell Disorder: Virulence and Fetal Morbidity
date: 2019-11-06
extension: .txt
mime: text/plain
words: 6462
sentence: 260
flesch: 55
cache: cache/cord-004053-nmt221tu.txt
txt: txt/cord-004053-nmt221tu.txt
summary:
  While Figure 2B , Figure 1B , and Table 2 provide evidence that disorder in the C protein contributes to the virulence of flaviviruses, Figure 1A , Figure 2A , Figure 3 , and Table 1 point to the contribution of ZIKV C protein disorder to fetal morbidity. Biomolecules Fundamentals of Molecular Virology Zika Virus Structure, Maturation, and Receptors Structure of the immature Zika virus at 9 Å resolution Intrinsically unstructured proteins: Re-assessing the protein structure-function paradigm Why are natively unfolded proteins unstructured under physiologic conditions? Intrinsically unstructured proteins Intrinsically Disordered Side of the Zika Virus Proteome Molecular Recognition Features in Zika Virus Proteome Correlating Flavivirus virulence and levels of intrinsic disorder in shell proteins: Protective roles vs. immune evasion Structural Disorder in Viral Proteins Orderly order in protein intrinsic disorder distribution: Disorder in 3500 proteomes from viruses and the three domains of life Disordered interactome of human papillomavirus Protein Intrinsic Disorder and Human Papillomaviruses: Increased Amount of Disorder in E6 and E7 Oncoproteins from High Risk HPVs Protein intrinsic disorder and influenza virulence: The 1918 H1N1 and H5N1 viruses Protein intrinsic disorder as a flexible armor and a weapon of HIV-1 Intrinsic disorder mediates hepatitis C virus core-host cell protein interactions


id: cord-292830-gcfx1095
author: Ianevski, Aleksandr
title: Novel activities of safe-in-human broad-spectrum antiviral agents
date: 2018-04-23
extension: .txt
mime: text/plain
words: 5527
sentence: 213
flesch: 38
cache: cache/cord-292830-gcfx1095.txt
txt: txt/cord-292830-gcfx1095.txt
summary:
  300 μL PBS was added to each well and the plate was analyzed in the Trophos plate runner HD (Trophos, Roche Group) to count the number of virus infected cells per well, by identifying all individual cells expressing the far-red fluorescent protein Katushka (Islam et al., 2018) . Combating emerging viral threats Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects Statins in HIV-infected patients: potential beneficial effects and clinical use Use of FDA approved therapeutics with hNTCP metabolic inhibitory properties to impair the HDV lifecycle Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice Treatment with lopinavir/ritonavir or interferon-beta1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Clinical Trial Resources Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study Curious (old and new) antiviral nucleoside analogues with intriguing therapeutic potential Approved antiviral drugs over the past 50 years Alisporivir inhibits MERS-and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model The future of antivirals: broad-spectrum inhibitors Chikungunya disease and chloroquine treatment Chloroquine, an endocytosis blocking agent, inhibits Zika virus infection in different cell models Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study Zika virus infection with prolonged maternal viremia and fetal brain abnormalities Infectious disease.


id: cord-260336-kwzo8puo
author: Si, Lulu
date: 2019-09-27
extension: .txt
mime: text/plain
words: 6407
sentence: 262
flesch: 54
cache: cache/cord-260336-kwzo8puo.txt
txt: txt/cord-260336-kwzo8puo.txt
title:
  A Peptide-Based Virus Inactivator Protects Male Mice Against Zika Virus-Induced Damage of Testicular Tissue

summary:
  To determine the protective effect of Z2 on ZIKV infection of testicular tissue, we tested if Z2 could inhibit infection by different ZIKV strains of Asian and African lineages in mouse Sertoli TM4 cells, which are nurse-like cells that support spermatogenesis (Wei et al., 2018) and important target cells for ZIKV testicular infection. However, no drug has been approved for prevention or treatment of ZIKV infection, especially infection in male testicular tissue.


id: cord-003187-qdbcdn2j
author: Bassi, Maria Rosaria
date: 2018-08-27
extension: .txt
mime: text/plain
words: 6761
sentence: 211
flesch: 30
cache: cache/cord-003187-qdbcdn2j.txt
txt: txt/cord-003187-qdbcdn2j.txt
title:
  Extinction of Zika Virus and Usutu Virus by Lethal Mutagenesis Reveals Different Patterns of Sensitivity to Three Mutagenic Drugs

summary:
  The crystal structure of Zika virus NS5 reveals conserved drug targets Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase Analysis of ribonucleotide 5=-triphosphate analogs as potential inhibitors of Zika virus RNAdependent RNA polymerase using non-radioactive polymerase assays Curing of foot-and-mouth disease virus from persistently infected cells by ribavirin involves enhanced mutagenesis Mode of action of ribavirin: effect of nucleotide pool alterations on influenza virus ribonucleoprotein synthesis Persistence of West Nile virus Zika virus persistence in the central nervous system and lymph nodes of rhesus monkeys The role of viral persistence in flavivirus biology Mutagenesis-induced, large fitness variations with an invariant arenavirus consensus genomic nucleotide sequence Zika virus infection of rhesus macaques leads to viral persistence in multiple tissues Late sexual transmission of Zika virus related to persistence in the semen Sexually acquired Zika virus: a systematic review Update: interim guidance for prevention of sexual transmission of Zika virus-United States Persistent detection of Zika virus RNA in semen for six months after symptom onset in a traveller returning from Haiti to Italy, February 2016 Mosquito-borne and sexual transmission of Zika virus: recent developments and future directions Prevention and control of Zika as a mosquito-borne and sexually transmitted disease: a mathematical modeling analysis The risk of sustained sexual transmission of Zika is underestimated Zika virus infects human placental macrophages Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model The viral polymerase inhibitor 7-deaza-2=-C-methyladenosine is a potent inhibitor of in vitro Zika virus replication and delays disease progression in a robust mouse infection model The race to find antivirals for Zika virus First evidence of simultaneous occurrence of West Nile virus and Usutu virus neuroinvasive disease in humans in Croatia during the 2013 outbreak Limited susceptibility of mice to Usutu virus (USUV) infection and induction of flavivirus cross-protective immunity A recombinant DNA vaccine protects mice deficient in the alpha/beta interferon receptor against lethal challenge with Usutu virus Emergence of Usutu virus, an African mosquito-borne Flavivirus of the Japanese encephalitis virus group Virus isolation and quantitation Isolation of fidelity variants of RNA viruses and characterization of virus mutation frequency Norovirus polymerase fidelity contributes to viral transmission in vivo A rapid and specific real-time RT-PCR assay to identify Usutu virus in human plasma, serum, and cerebrospinal fluid Coxsackievirus B3 mutator strains are attenuated in vivo


id: cord-300459-tu2xrt9x
author: Li, Cui
date: 2018-05-01
extension: .txt
mime: text/plain
words: 6849
sentence: 269
flesch: 50
cache: cache/cord-300459-tu2xrt9x.txt
txt: txt/cord-300459-tu2xrt9x.txt
title:
  A Single Injection of Human Neutralizing Antibody Protects against Zika Virus Infection and Microcephaly in Developing Mouse Embryos

summary:
  To address this, we investigated six human monoclonal antibodies with ZIKV epitope specificity and neutralizing activity in mouse models of ZIKV infection and microcephaly. A single intraperitoneal injection of these antibodies conveyed distinct levels of adult and in utero protection from ZIKV infection, which closely mirrored their respective in vitro neutralizing activities.


id: cord-002341-v4r5d26a
author: Chan, Jasper Fuk-Woo
date: 2016-11-12
extension: .txt
mime: text/plain
words: 7158
sentence: 242
flesch: 40
cache: cache/cord-002341-v4r5d26a.txt
txt: txt/cord-002341-v4r5d26a.txt
title:
  Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons

summary:
  Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys Characterization of lethal Zika virus infection in AG129 mice Fatal sickle cell disease and Zika virus infection in girl from Colombia Zika virus infection of the central nervous system of mice Acute glomerulonephritis in dengue haemorrhagic fever in the absence of shock, sepsis, haemolysis or rhabdomyolysis Isolation of infective Zika virus from urine and saliva of patients in Brazil Comparative analysis between Flaviviruses reveals specific neural stem cell tropism for Zika virus in the mouse developing Neocortex Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study Guillain-Barre syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study Zika virus associated with Meningoencephalitis Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Development and evaluation of novel realtime reverse transcription-PCR assays with locked nucleic acid probes targeting leader sequences of human-pathogenic coronaviruses Treatment with Lopinavir/ritonavir or interferon-beta1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Zika fever and congenital Zika syndrome: an unexpected emerging arboviral disease Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs An observational study of dengue fever in a tertiary care hospital of eastern India The Brazilian Zika virus strain causes birth defects in experimental models Ocular findings in infants with microcephaly associated with presumed Zika virus congenital infection in Salvador, Brazil Zika virus. In addition to the reported findings of detectable virus particles and/or RNA in the brain, spinal cord, kidney, spleen, liver, testis, ovary, heart, lung, muscle, and blood of types I/II interferon-signaling-/receptor-deficient mice with ZIKV infection, our study identified intestine, pancreas, and salivary gland as other possible tissues and anatomical sites for virus infection (Dick, 1952; Lazear et al., 2016; Dowall et al., 2016; Aliota et al., 2016; Rossi et al., 2016) .


id: cord-273326-gmw8gl2r
author: Saiz, Juan-Carlos
title: Host-Directed Antivirals: A Realistic Alternative to Fight Zika Virus
date: 2018-08-24
extension: .txt
mime: text/plain
words: 7153
sentence: 232
flesch: 28
cache: cache/cord-273326-gmw8gl2r.txt
txt: txt/cord-273326-gmw8gl2r.txt
summary:
  Front Pathogenic exploitation of Fc activity Pathogenesis of flavivirus infections: Using and abusing the host cell Role of host cell factors in flavivirus infection: Implications for pathogenesis and development of antiviral drugs Broad-spectrum agents for flaviviral infections: Dengue, zika and beyond Targeting host factors to treat West Nile and dengue viral infections Zika virus replicons for drug discovery Establishment and application of flavivirus replicons Probing molecular insights into Zika virus (-)host interactions Zika virus cell tropism in the developing human brain and inhibition by azithromycin Genetic ablation of axl does not protect human neural progenitor cells and cerebral organoids from Zika virus infection Axl mediates Zika virus entry in human glial cells and modulates innate immune responses Axl is not an indispensable factor for Zika virus infection in mice Axl-mediated productive infection of human endothelial cells by Zika virus Curcumin inhibits zika and chikungunya virus infection by inhibiting cell binding Polysulfonate suramin inhibits Zika virus infection Suramin inhibits Zika virus replication by interfering with virus attachment and release of infectious particles Molecular mechanisms of flavivirus membrane fusion Acid-dependent viral entry Screening bioactives reveals nanchangmycin as a broad spectrum antiviral active against Zika virus Lipids and flaviviruses, present and future perspectives for the control of dengue, zika, and West Nile viruses Arbidol (umifenovir): A broad-spectrum antiviral drug that inhibits medically important arthropod-borne flaviviruses Infection by Zika viruses requires the transmembrane protein AXL, endocytosis and low pH 25-hydroxycholesterol protects host against Zika virus infection and its associated microcephaly in a mouse model A screen of FDA-approved drugs for inhibitors of Zika virus infection Obatoclax, saliphenylhalamide and gemcitabine inhibit Zika virus infection in vitro and differentially affect cellular signaling, transcription and metabolism Obatoclax inhibits alphavirus membrane fusion by neutralizing the acidic environment of endocytic compartments Evaluation of anti-Zika virus activities of broad-spectrum antivirals and NIH clinical collection compounds using a cell-based, high-throughput screen assay Chloroquine, an endocytosis blocking agent, inhibits Zika virus infection in different cell models Antiviral activities of selected antimalarials against dengue virus type 2 and Zika virus Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice FDA-approved drug, prevents Zika virus infection and its associated congenital microcephaly in mice Repurposing of the anti-malaria drug chloroquine for Zika virus treatment and prophylaxis -(arylmethylimino)ethyl)-7-chloroquinolin-4-amine derivatives, synthesized by thermal and ultrasonic means, are endowed with anti-Zika virus activity (trifluoromethyl)quinoline analogs show improved anti-Zika virus activity, compared to mefloquine The antimalarial drug amodiaquine possesses anti-Zika virus activities Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen Niclosamide rescues microcephaly in a humanized in vivo model of zika infection using human induced neural stem cells Antiviral effects of ferric ammonium citrate Inhibition of Zika virus replication by silvestrol Antiviral activity of N-(4-hydroxyphenyl) retinamide (4-HPR) against Zika virus Interferon-induced spermidine-spermine acetyltransferase and polyamine depletion restrict zika and chikungunya viruses Inhibition of polyamine biosynthesis is a broad-spectrum strategy against rna viruses The composition of West Nile virus lipid envelope unveils a role of sphingolipid metabolism in flavivirus biogenesis Direct activation of adenosine monophosphate-activated protein kinase (AMPK) by PF-06409577 inhibits flavivirus infection through modification of host cell lipid metabolism Suppression of Zika virus infection and replication in endothelial cells and astrocytes by PKA inhibitor PKI 14-22 Zika virus targets human STAT2 to inhibit type I interferon signaling Ribavirin-Current status of a broad spectrum antiviral agent Broad-spectrum antiviral activity of the imp dehydrogenase inhibitor VX-497: A comparison with ribavirin and demonstration of antiviral additivity with alpha interferon Rna virus error catastrophe: Direct molecular test by using ribavirin Extinction of hepatitis c virus by ribavirin in hepatoma cells involves lethal mutagenesis Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model In vitro susceptibility of geographically and temporally distinct Zika viruses to favipiravir and ribavirin Ribavirin inhibits Zika virus (zikv) replication in vitro and suppresses viremia in zikv-infected stat1-deficient mice Favipiravir and ribavirin inhibit replication of Asian and African strains of Zika virus in different cell models an impdh inhibitor, suppresses replication of Zika virus and other emerging viral pathogens A sensitive virus yield assay for evaluation of antivirals against Zika virus Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity Discovery of a broad-spectrum antiviral compound that inhibits pyrimidine biosynthesis and establishes a type 1 interferon-independent antiviral state High-content screening in HPSC-neural progenitors identifies drug candidates that inhibit Zika virus infection in fetal-like organoids and adult brain The Brazilian Zika virus strain causes birth defects in experimental models Zika virus impairs growth in human neurospheres and brain organoids Zika virus disrupts neural progenitor development and leads to microcephaly in mice N-methyl-D-aspartate (NMDA) receptor blockade prevents neuronal death induced by Zika virus infection Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmission Zika virus infectious cell culture system and the in vitro prophylactic effect of interferons Type iii interferons produced by human placental trophoblasts confer protection against Zika virus infection Gestational stage and IFN-lambda signaling regulate ZIKV infection in utero The IFITMs inhibit Zika virus replication


id: cord-003482-f1uvohf0
author: Malmlov, Ashley
date: 2019-02-04
extension: .txt
mime: text/plain
words: 7514
sentence: 364
flesch: 51
cache: cache/cord-003482-f1uvohf0.txt
txt: txt/cord-003482-f1uvohf0.txt
title:
  Experimental Zika virus infection of Jamaican fruit bats (Artibeus jamaicensis) and possible entry of virus into brain via activated microglial cells

summary:
  Isolation and haemagglutination-inhibition studies on bats collected in Kenya and throughout Uganda Effect of Zika virus and Bwamba virus in the cave bat (Myotis lucifugus) Transmission studies of Hendra virus (equine morbillivirus) in the fruit bats, horses and cats Pteropid bats are confirmed as the reservoir hosts of henipaviruses: A comprehensive experimental study of virus transmission Antibody-mediated immune response in the bat, Pteropus giganteus Detection of specfic antibody responses to vaccinatin in variable flying foxes (Pteropus hypomelanus) The little brown bat, M. lucifugus, displays a highly diverse VH, DH, JH repertoire but little evidence of somatic hypermutation Tacaribe virus cases fatal infection of an ostensible reservoir host, the Jamaican fruit bat Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis) Transcriptomic signatures of tacaribe virus-infected Jamaican fruit bats Assay optimization for molecular detection of Zika virus A rhesus macaque model of Asian-lineage Zika virus infection Zika virus testing considerations: lessons learned from the first eighty real-time RT-PCR-positive cases diagnosed in New York State Detection of Zika virus in urine Long-term kinetics of Zika virus RNA and antibodies in body fluids of a vasectomized traveller returning from Martinique: a case report Persistence of Zika virus in body fluids-Preliminary report Zika virus causes testis damage and leads to male infertility in mice Zika virus infection damages the testes in mice A mouse model of Zika virus pathogenesis Zika viral infection and neutralizing human antibody response in a BLT humanized mouse model Notes from the field: Evidence of Zika virus infection in brain and placental tissues from two congenitally infected newborns and two fetal losses-Brazil Zika virus damages the human placental barrier and presents marked fetal neurotropism Pathology of congenital Zika syndrome in Brazil: a case series Zika virus infection of rhesus macaques leads to viral persistence in multiple tissues Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate Nonhuman primate models of Zika virus infection, immunity, and therapeutic development Zika viral dynamics and shedding in rhesus and cynomolgus macaques Overview of the current status of Zika virus pathogenesis and animal related research Axl mediates Zika virus entry in human glial cells and modulates innate immune responses Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity Entry sites of Venezuelan and western equine encephalitis viruses in the mouse central nervous system following peripheral infection Detection of Zika virus in saliva Biology of Zika virus infection in human skin cells Denge virus in Mexican bats Neotropical bats that co-habit with humans function as dead-end hosts for dengue virus Detection of dengue virus neutralizing antibodies in bats from Costa Rica and Ecuador Sylvatic transmission of arboviruses among bornean orangutans Zika virus, vectors, reservoirs, amplifying hosts, and their potential to spread worldwide: what we know and what we should investigate urgently A sero-epidemiological survey for certain arboviruses (Togaviridae) in Pakistan Investigating the potential role of North American animals as hosts for Zika virus. Distribution of viral antigen in bat tissues suggests that infection in this species recapitulates human infection, which is thought to start with infection of epidermal and dermal cells with subsequent dissemination to multiple organs including salivary glands as viral RNA can be detected in human saliva [44, 45] .


id: cord-004020-qtwcbn7m
author: Gao, Yaning
title: Identification of Novel Natural Products as Effective and Broad-Spectrum Anti-Zika Virus Inhibitors
date: 2019-11-02
extension: .txt
mime: text/plain
words: 7718
sentence: 257
flesch: 42
cache: cache/cord-004020-qtwcbn7m.txt
txt: txt/cord-004020-qtwcbn7m.txt
summary:
  Anti-ZIKV compounds, such as temoporfin [28] , 25-hydroxycholesterol [29] , bortezomib [16] , and NITD008 No therapeutic agents have, so far, been approved for the treatment of ZIKV infection in humans; as such, there is a need for a continuous effort to develop effective and safe antiviral drugs to treat ZIKV-caused diseases.


id: cord-263868-ewnf96cz
author: Srivastava, Mayank
title: Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor
date: 2020-08-04
extension: .txt
mime: text/plain
words: 7640
sentence: 312
flesch: 45
cache: cache/cord-263868-ewnf96cz.txt
txt: txt/cord-263868-ewnf96cz.txt
summary:
  We devised and synthesized a multifunctional chemical probe ( Fig. 1a; Supplementary Figs. 1-3) bearing a labeling group that conjugates the probe to the ZIKV surface, a photo-reactive group that allows for covalent crosslinking of ZIKV proteins to interacting host cell proteins upon UV exposure, and an isolation tag of biotin for purifying the interacting proteins for quantitative MS analysis, thus facilitating the investigation of host-pathogen interactomes in a time-resolved manner (Fig. 1b) . 4F2 cell-surface antigen heavy chain (SLC3A2) was reported interacting with ZIKV NS4B protein and was indicated as a candidate host factor for ZIKV infection 12 .


id: cord-338136-nbtkl5cx
author: Clemente, Nuria Sanchez
title: Geographies of risk: Emerging infectious diseases and travel health data
date: 2020-06-25
extension: .txt
mime: text/plain
words: 1150
sentence: 43
flesch: 35
cache: cache/cord-338136-nbtkl5cx.txt
txt: txt/cord-338136-nbtkl5cx.txt
summary:
  key: cord-338136-nbtkl5cx authors: Clemente, Nuria Sanchez; Ramond, Anna; Turchi Martelli, Celina Maria; Brickley, Elizabeth B. title: Geographies of risk: Emerging infectious diseases and travel health data date: 2020-06-25 journal: Reflecting on the findings of Petridou and colleagues, 1 describing imported ZIKV cases to the UK between 2016-2018, confirmed at the Rare and Imported Pathogens Laboratory, we look back to the 2015-2017 Zika virus (ZIKV) pandemic and reflect on some of the opportunities and limitations presented by data obtained from returning travellers in enhancing understanding of emerging infectious diseases.


id: cord-321312-hgp2jwbl
author: Carvalho, Sandhra M.
date: 2020-07-10
extension: .txt
mime: text/plain
words: 1905
sentence: 73
flesch: 37
cache: cache/cord-321312-hgp2jwbl.txt
txt: txt/cord-321312-hgp2jwbl.txt
title:
  Fluorescent Quantum Dots-Zika Virus Hybrid Nanoconjugates for Biolabeling, Bioimaging, and Tracking Host-Cell Interactions

summary:
  The cytocompatibility in vitro of ZAIS QDs for biological applications was assessed using MTT protocol, where the cell viability responses (≥95 %) towards VERO cells after 24 h of incubation are presented in Fig. 2B . VERO cells treated with unbound ZIKV and ZAIS QDs were used as controls (images, Fig.


id: cord-003041-v9uevz3l
author: Zukor, Katherine
date: 2018-02-23
extension: .txt
mime: text/plain
words: 8927
sentence: 315
flesch: 42
cache: cache/cord-003041-v9uevz3l.txt
txt: txt/cord-003041-v9uevz3l.txt
title:
  Zika virus-induced acute myelitis and motor deficits in adult interferon αβ/γ receptor knockout mice

summary:
  While ZIKV infection of adults generally produces only a mild disease, it is becoming apparent that, as with other flavivirus infections, severe neurological sequelae can occur. Given the emerging nature of ZIKV, however, it is likely that we do not fully understand the acute and long-term consequences of ZIKV infection on the nervous system.


id: cord-003284-hjx2d5rq
author: Márquez-Jurado, Silvia
date: 2018-10-07
extension: .txt
mime: text/plain
words: 9963
sentence: 325
flesch: 44
cache: cache/cord-003284-hjx2d5rq.txt
txt: txt/cord-003284-hjx2d5rq.txt
title:
  An Alanine-to-Valine Substitution in the Residue 175 of Zika Virus NS2A Protein Affects Viral RNA Synthesis and Attenuates the Virus In Vivo

summary:
  This DNA-lunched system ensures capping of the viral RNA and allows the recovery of infectious virus from the transfected cDNA clone without the need of an in vitro transcription step. In contrast to mock-transfected cells, increasing amounts of infectious virus were detected in the tissue culture supernatant of cells transfected with the infectious clone, with peak titers around 10 7 PFU/mL on day five ( Figure 2A ).


id: cord-345238-p841weif
author: Magalhaes, Tereza
title: The Endless Challenges of Arboviral Diseases in Brazil
date: 2020-05-09
extension: .txt
mime: text/plain
words: 1664
sentence: 53
flesch: 30
cache: cache/cord-345238-p841weif.txt
txt: txt/cord-345238-p841weif.txt
summary:
  One year after the Zika virus outbreak in Brazil: From hypotheses to evidence Serological tests reveal significant cross-reactive human antibody responses to Zika and Dengue viruses in the Mexican population Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region Previous dengue or Zika virus exposure can drive to infection enhancement or neutralisation of other flaviviruses Dengue Virus and Zika Virus Serological Cross-reactivity and Their Impact on Pathogenesis in Mice Impacts of Zika emergence in Latin America on endemic dengue transmission The decline of dengue in the Americas in 2017: Discussion of multiple hypotheses Human Urban Arboviruses Can Infect Wild Animals and Jump to Sylvatic Maintenance Cycles in South America A list of mosquito species of the Brazilian State of Pernambuco, including the first report of Haemagogus janthinomys (Diptera: Culicidae), yellow fever vector and 14 other species (Diptera: Culicidae) Spatial distribution and exploitation of trees gouged by common marmosets (Callithrix jacchus) Evidence of natural Zika virus infection in neotropical non-human primates in Brazil Seroprevalence of selected flaviviruses in free-living and captive capuchin monkeys in the state of Pernambuco Limited Evidence for Infection of Urban and Peri-urban Nonhuman Primates with Zika and Chikungunya Viruses in Brazil Zika Virus Surveillance at the Human-Animal Interface in West-Central Brazil Prevalence and Incidence of Zika Virus Infection Among Household Contacts of Patients With Zika Virus Disease Influenza Illness among Case-Patients Hospitalized for Suspected Dengue Frequency and clinical features of dengue infection in a schoolchildren cohort from medellin, Colombia Severe coinfections of dengue and pandemic influenza A H1N1 viruses Co-infection with dengue virus and pandemic (H1N1) 2009 virus The diagnostic challenge of pandemic H1N1 2009 virus in a dengue-endemic region: In addition, virus transmission during the outbreaks was focal across metropolitan regions, where some areas were more intensely hit than others within the same municipality [4] , corroborating the notion of clustered household/community transmission of arboviruses transmitted by Ae. aegypti.


id: cord-330743-o11d0aa1
author: Yu, Xi
date: 2020-05-25
extension: .txt
mime: text/plain
words: 4488
sentence: 178
flesch: 47
cache: cache/cord-330743-o11d0aa1.txt
txt: txt/cord-330743-o11d0aa1.txt
title:
  Broad-spectrum virucidal activity of bacterial secreted lipases against flaviviruses, SARS-CoV-2 and other enveloped viruses

summary:
  Incubation of the culture supernatant but not the bacterial lysates resulted in significant suppression of DENV ( Figure 1B ) and ZIKV ( Figure 1C ) infectivity in Vero cells, indicating that an extracellular effector(s) secreted by Csp_BJ was responsible for viral inhibition. Either the upper retentate (proteins and large peptides) or the lower liquid filtrate (small molecule compounds and short peptides) was mixed with the viruses for incubation in Vero cells ( Figure 1D ).


id: cord-309275-soffxxqu
author: Li, Shuang
title: DEFA1B inhibits ZIKV replication and retards cell cycle progression through interaction with ORC1
date: 2020-10-17
extension: .txt
mime: text/plain
words: 3972
sentence: 165
flesch: 45
cache: cache/cord-309275-soffxxqu.txt
txt: txt/cord-309275-soffxxqu.txt
summary:
  CCK-8 and flow cytometry were used to test the cell proliferation and cell cycles. Our study provides a novel concept that DEFA1B not only acts as an antiviral molecule during ZIKV infection but also may correlate with cell proliferation by retarding the progression of cell cycles.


id: cord-298166-045evk7g
author: Röcker, Annika E.
title: The molecular tweezer CLR01 inhibits Ebola and Zika virus infection
date: 2018-02-08
extension: .txt
mime: text/plain
words: 5846
sentence: 237
flesch: 49
cache: cache/cord-298166-045evk7g.txt
txt: txt/cord-298166-045evk7g.txt
summary:
  Detection of Zika virus in semen Safety and pharmacological characterization of the molecular tweezer CLR01-a broad-spectrum inhibitor of amyloid proteins' toxicity Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers A screen of FDA-approved drugs for inhibitors of Zika virus infection Lipid raft microdomains Combating emerging viral threats The HIV lipidome: a raft with an unusual composition Drug Selectivity: an Evolving Concept in Medicinal Chemistry Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study Ebola Outbreak in West Africa -Case Counts Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides Virus entry, assembly, budding, and membrane rafts. As no preventive vaccines or antiviral drugs against these two re-emerging pathogens are available, we evaluated whether the molecular tweezer CLR01 may inhibit EBOV and ZIKV infection.


id: cord-354546-lgkqwm6u
author: Yin, Yingxian
date: 2016-09-07
extension: .txt
mime: text/plain
words: 4093
sentence: 163
flesch: 50
cache: cache/cord-354546-lgkqwm6u.txt
txt: txt/cord-354546-lgkqwm6u.txt
title:
  Epidemiologic investigation of a family cluster of imported ZIKV cases in Guangdong, China: probable human-to-human transmission

summary:
  A bibliometric analysis of global Zika research Zika virus and Guillain-Barre syndrome: another viral cause to add to the list Guillain-Barre syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study Neurological expertise is essential for Zika virus infection Zika virus infects human cortical neural progenitors and attenuates their growth Biology of Zika virus infection in human skin cells Characterization of lethal Zika virus infection in AG129 mice Zika virus: the latest newcomer Zika virus in Gabon (Central Africa)-2007: a new threat from Aedes albopictus The Zika outbreak of the 21st century Probable non-vector-borne transmission of Zika virus Potential sexual transmission of Zika virus Zika: another sexually transmitted infection? An animal model of ZIKV infection has been established in AG129 mice by foot pad injection.


id: cord-311007-0i1abjfa
author: Schwarz, Megan C.
title: Rescue of the 1947 Zika Virus Prototype Strain with a Cytomegalovirus Promoter-Driven cDNA Clone
date: 2016-09-28
extension: .txt
mime: text/plain
words: 4869
sentence: 187
flesch: 44
cache: cache/cord-311007-0i1abjfa.txt
txt: txt/cord-311007-0i1abjfa.txt
summary:
  Parallel infection of 293T cells with the parent MR766 virus resulted in supernatants containing between 2.6 ϫ 10 7 and 2.2 ϫ 10 8 TCID 50 /ml. To compare the fitness levels of our parental and rescued MR766 viruses, we first calculated their Vero cell specific infectivities.


id: cord-300379-db79kb5c
author: Park, Jun-Gyu
title: Potent Inhibition of Zika Virus Replication by Aurintricarboxylic Acid
date: 2019-04-12
extension: .txt
mime: text/plain
words: 5171
sentence: 160
flesch: 40
cache: cache/cord-300379-db79kb5c.txt
txt: txt/cord-300379-db79kb5c.txt
summary:
  ADE, which has been extensively described in DENV (Priyamvada et al., 2017) , is a phenomenon where preexisting antibodies facilitate binding and infection during subsequent exposure to infectious viruses, instead of neutralizing them, resulting in exacerbation of clinical signs Priyamvada et al., 2017) . Because of the structural similarities between DENV and ZIKV, DENV immunity-linked ADE of ZIKV infection has also been reported Priyamvada et al., 2017) .


id: cord-332473-ec8lu2a3
author: Amorim, Raquel
title: Zika virus inhibits eIF2α-dependent stress granule assembly
date: 2017-07-17
extension: .txt
mime: text/plain
words: 6570
sentence: 285
flesch: 48
cache: cache/cord-332473-ec8lu2a3.txt
txt: txt/cord-332473-ec8lu2a3.txt
summary:
  ZIKV is a positive-strand RNA virus that replicates in the cytoplasm but little is known about redistribution of host proteins in ZIKV infected cells. In contrast, ZIKV infected cells presented SG at a rate of only 21.6% (Fig 2A, bottom panel and Fig 2B) .


id: cord-294798-ji3p0l4j
author: White, Sarah K.
date: 2018-05-31
extension: .txt
mime: text/plain
words: 4796
sentence: 161
flesch: 41
cache: cache/cord-294798-ji3p0l4j.txt
txt: txt/cord-294798-ji3p0l4j.txt
title:
  Detection and phylogenetic characterization of arbovirus dual-infections among persons during a chikungunya fever outbreak, Haiti 2014

summary:
  As part of ongoing screening of schoolchildren presenting with acute undifferentiated febrile illness in rural Haiti, we used RT-PCR to identify CHIKV infections in 82 of 100 children with this diagnosis during May—August 2014. The acute symptoms of CHIKV infection are similar to those of infection with other arbovirus species, including Dengue virus (DENV), Zika virus (ZIKV), and Mayaro virus (MAYV), each presenting with a constellation of symptoms including fever, headache, and myalgias/arthralgias.


id: cord-326512-iex98lr1
author: Niu, Xuefeng
date: 2019-05-25
extension: .txt
mime: text/plain
words: 5674
sentence: 239
flesch: 53
cache: cache/cord-326512-iex98lr1.txt
txt: txt/cord-326512-iex98lr1.txt
title:
  Convalescent patient-derived monoclonal antibodies targeting different epitopes of E protein confer protection against Zika virus in a neonatal mouse model

summary:
  For antigen-specific memory B cells, we used ZIKV E protein (Cat. no. 40543-V08B4; Sino Biological Inc., Beijing, China) as a probe. Amino acid sequence alignment between E proteins of ZIKV and DENV revealed that residue K394 on ZIKV E protein corresponds to K385 on DENV1, which is not present on the E proteins of DENV2, DENV3, or DENV4 ( Figure 2(D) ).


id: cord-283405-aozxvxxs
author: Vermillion, Meghan S.
title: Pregnancy and infection: using disease pathogenesis to inform vaccine strategy
date: 2018-02-01
extension: .txt
mime: text/plain
words: 8432
sentence: 276
flesch: 21
cache: cache/cord-283405-aozxvxxs.txt
txt: txt/cord-283405-aozxvxxs.txt
summary:
  This enables production of a vaccine strain with maximum efficacy and safety, and represents another promising alternative to conventional attenuated or killed virus vaccines. Recombinant virus vaccines, however, warrant careful consideration of the safety of the vector itself, especially in pregnant women.


id: cord-319781-6thdg2up
author: Payne, Kelly
date: 2020-07-24
extension: .txt
mime: text/plain
words: 8239
sentence: 343
flesch: 45
cache: cache/cord-319781-6thdg2up.txt
txt: txt/cord-319781-6thdg2up.txt
title:
  Twenty-First Century Viral Pandemics: A Literature Review of Sexual Transmission and Fertility Implications in Men

summary:
  SARS-Cov-2, the most recent viral pandemic included in this review, is expected to behave similar to SARS virus, but further data are required to validate these assumptions. ELevated 17b-estradiol protects females from influenza A virus pathogenesis by suppressing inflammatory responses Critically ill children during the 2009-2010 influenza pandemic in the United States Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection Probable noneVectorborne transmission of Zika virus Persistence and clinical relevance of Zika virus in the male genital tract Zika virus shedding in semen of symptomatic infected men Effect of acute Zika virus infection on sperm and virus clearance in body fluids: a prospective observational study Sexual transmission of Zika virus and other flaviviruses: a living systematic review Persistence of Zika virus in body fluids -Final report Zika virus infects human testicular tissue and germ cells Sexually acquired Zika virus: a systematic review Low risk of a sexuallytransmitted Zika virus outbreak The dual role of the immune response in reproductive organs during Zika virus infection Zika virus causes testicular atrophy Zika virus infection damages the testes in mice Zika virus in semen: a prospective cohort study of symptomatic travellers returning to Belgium Potential effect of Zika virus infection on human male fertility? Ebola (Ebola Virus Disease)


id: cord-262944-9k64f0tw
author: Parker, Elaine L.
title: Viral-Immune Cell Interactions at the Maternal-Fetal Interface in Human Pregnancy
date: 2020-10-07
extension: .txt
mime: text/plain
words: 9825
sentence: 313
flesch: 32
cache: cache/cord-262944-9k64f0tw.txt
txt: txt/cord-262944-9k64f0tw.txt
summary:
  This also demonstrates that dNK cells are able to localize and target HCMV infected cells while sparing fetal derived semiallogenic trophoblast cells (80) . This study proved, through antibody mediated abrogation of the Fas ligand (FasL) and tumor necrosis factor-related apoptosis-induced ligand (TRAIL) on dNK cells, that death of HCMV infected cells is not initiated by dNK cells through these death receptor-ligand pathways.


id: cord-340907-j9i1wlak
author: Zarai, Yoram
title: Evolutionary selection against short nucleotide sequences in viruses and their related hosts
date: 2020-04-27
extension: .txt
mime: text/plain
words: 8168
sentence: 336
flesch: 41
cache: cache/cord-340907-j9i1wlak.txt
txt: txt/cord-340907-j9i1wlak.txt
summary:
  The virus and host coding sequences and association information was retrieved from a published database. We provide various novel discoveries that may shed light on the evolution of viral DNA sequences and on the virus co-evolution with its respective hosts.


id: cord-295351-0zr2e8lh
author: Mohd Ropidi, Muhammad Izzuddin
title: Endoplasmic reticulum: a focal point of Zika virus infection
date: 2020-01-20
extension: .txt
mime: text/plain
words: 7858
sentence: 334
flesch: 32
cache: cache/cord-295351-0zr2e8lh.txt
txt: txt/cord-295351-0zr2e8lh.txt
summary:
  ZIKV proteins localize to distinct subcellular compartments ZIKV proteins are primarily distributed within and in close proximity to several endomembrane compartments including the endoplasmic reticulum, Golgi apparatus, endosomes, lysosomes, autophagosomes, and nucleus The subcellular distribution of certain ZIKV proteins was corroborated in a separate study where interatomic analyses using proximity-dependent biotin-identification (BioID) labeling and FLAG-based immunoprecipitation (IP) coupled with mass spectrometry (MS) uncover indepth molecular interactions between ZIKV proteins with various host organelles and proteins.


id: cord-341907-vql8e2j3
author: Wang, Xinyi
date: 2019-10-27
extension: .txt
mime: text/plain
words: 7603
sentence: 283
flesch: 48
cache: cache/cord-341907-vql8e2j3.txt
txt: txt/cord-341907-vql8e2j3.txt
title:
  Effects of Adjuvants on the Immunogenicity and Efficacy of a Zika Virus Envelope Domain III Subunit Vaccine

summary:
  Briefly, ELISA plates were coated with ZIKV EDIII protein, ZIKV full-length E protein with a His 6 tag (Aviva Systems Biology, San Diego, CA, USA), or a C-terminal hFc-fused control protein containing a receptor-binding domain (i.e., RBD-Fc) of Middle East respiratory syndrome coronavirus (MERS-CoV) spike protein [31] (1 µg/mL) overnight at 4 • C, and blocked with 2% fat-free milk in PBST (PBS containing tween-20) at 37 • C for 2 h. In particular, neutralizing antibodies, induced by ZIKV vaccines, may block infection [27, 46] , while CD4 + and CD8 + T cells secrete IFN-γ, IL2 (Th1), IL-4, and IL-5 (Th2) cytokines to further promote antibody production or directly kill infected cells


id: cord-290385-0smnl70i
author: Chan, Jasper F.W.
title: Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease
date: 2016-03-03
extension: .txt
mime: text/plain
words: 8262
sentence: 319
flesch: 36
cache: cache/cord-290385-0smnl70i.txt
txt: txt/cord-290385-0smnl70i.txt
summary:
  Domain III peptides from flavivirus envelope protein are useful antigens for serologic diagnosis and targets for immunization A single mutation in chikungunya virus affects vector specificity and epidemic potential Spread of the pandemic Zika virus lineage is associated with NS1 codon usage adaptation in humans Biology of Zika virus infection in human skin cells Autophagy and viral diseases transmitted by Aedes aegypti and Aedes albopictus Zika virus infection of the central nervous system of mice Zika virus: further isolations in the Zika area, and some studies on the strains isolated Persistence of arboviruses and antiviral antibodies in vertebrate hosts: its occurrence and impacts Incubation periods of mosquito-borne viral infections: a systematic review Rapid risk assessment: Zika virus infection outbreak, French Polynesia Current Zika virus epidemiology and recent epidemics Zika virus outbreak Zika virus infection in man Zika virus infection, Cambodia Fatal Zika virus infection in girl with sickle cell disease, Colombia. Zika situation report e neurological syndrome and congenital anomalies Zika virus infection acquired during brief travel to Indonesia First case of Zika virus infection in a returning Canadian traveler Two cases of Zika fever imported from French Polynesia to Japan First case of laboratory-confirmed Zika virus infection imported into Europe Zika virus infection after travel to Tahiti Zika virus infection in a traveller returning to Europe from Brazil Zika virus infections imported to Italy: clinical, immunological and virological findings, and public health implications Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase Zika virus in an American recreational traveler Acute Zika virus infection after travel to Malaysian Borneo Zika fever imported from Thailand to Japan, and diagnosed by PCR in the urines Zika virus infection in a traveller returning from the Maldives Epidemiological alert e neurological syndrome, congenital malformations, and Zika virus infection.


id: cord-310004-h9ixhhzz
author: Yuan, Shuofeng
date: 2020-08-28
extension: .txt
mime: text/plain
words: 9566
sentence: 399
flesch: 43
cache: cache/cord-310004-h9ixhhzz.txt
txt: txt/cord-310004-h9ixhhzz.txt
title:
  Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target

summary:
  ACA targets host AP2M1 protein ACA is known as a phospholipase A2 (PLA2) inhibitor and transient receptor potential (TRP) channel blocker (15) , but such mechanisms for suppressing viral replication were excluded ( fig. (D) Histopathologic and immunohistochemistry (IHC) analyses of the brain samples at 6 dpi indicated less severe meningitis (by H&E, ×200) and less virus infected cells as indicated by ZIKV NS1 antigen staining (red arrows, by IHC, ×200 magnification) after ACA treatment.


id: cord-015352-2d02eq3y
title: ESPR 2017
date: 2017-04-26
extension: .txt
mime: text/plain
words: 82384
sentence: 3820
flesch: 43
cache: cache/cord-015352-2d02eq3y.txt
txt: txt/cord-015352-2d02eq3y.txt
summary:
  In 2011, the image gently campaign released a safety checklist for performing digital radiography examinations on pediatric patients which is easily applicable to every radiology service. Health care professionals have a shared responsibility for communicating risks and benefits of imaging procedures to patients, especially in the case of pediatric patients.


id: cord-010119-t1x9gknd
title: Abstract Presentations from the AABB Annual Meeting San Diego, CA ctober 7‐10, 2017
date: 2017-09-04
extension: .txt
mime: text/plain
words: 230433
sentence: 10311
flesch: 50
cache: cache/cord-010119-t1x9gknd.txt
txt: txt/cord-010119-t1x9gknd.txt
summary:
  Probability of occurrence of cannabis metabolites in blood donor samples is likely to be highly variable across donor centers and is largely dependent on blood donor demographics. OBRR, CBER, FDA Background/Case Studies: Extended molecular typing of a large number of blood donors can increase the likelihood of identifying donor red blood cells (RBCs) that match those of the recipient.


