item: #1 of 251 id: aaem-583 author: Yousefi, Hesam title: Anaphylaxis as a Rare Side Effect of Ketorolac; a Case Report date: 2020 words: 1622 flesch: 50 summary: A 51-year-old man with urolithiasis developed anaphylaxis after an intravenous injection of 30 mg ketorolac. He was admitted to the emergency department of Vali-Asr Hospital in Arak, Iran. He had been having mild pain in his flanks since the night before. Ketorolacl is an NSAID used to alleviate renal colic. keywords: administration; allergic; anaphylactic; anaphylaxis; anti; arak; article; case; department; drug; effect; emergency; hospital; injection; intravenous; iran; journal; ketorolac; life; medical; nsaids; nursing; old; pain; patient; rare; reaction; report; sciences; university; year cache: aaem-583.pdf plain text: aaem-583.txt item: #2 of 251 id: admet-796 author: Dixit, Abhishek title: Validated DBS method for filgotinib quantitation in rat dried blood spots and its application to a pharmacokinetic study in rats date: 2020 words: 4865 flesch: 51 summary: Filgotinib is a selective JAK1 (Janus kinase) inhibitor. It is effective in patients with moderate-to-severe rheumatoid arthritis. Abhishek Dixit, Vinay Kiran, Bhavesh Babulal Gabani, Ramesh Mullangi, and others developed a validated DBS method for filgotin ib quantitation in rat dried blood spots and applied it to a pharmacokinetic study in rats. keywords: 8(2; access; accuracy; acetate; acetonitrile; acid; administration; analysis; arthritis; blood; calibration; cards; chromatography; concentration; conditions; data; dbs; dmpk; dose; drug; effect; ethyl; extraction; figure; filgotinib; formic; http://dx.doi.org/10.5599/admet.796; inhibitor; intravenous; jak1; mass; matrix; mean; methanol; method; mullangi; oral; parameters; patients; pharmacokinetic; plasma; post; precision; quantitation; rat; rats; recovery; reported; rheumatoid; rsd; samples; selective; spiked; spots; standard; stock; study; table; temperature; time; validation; values; volume; water cache: admet-796.pdf plain text: admet-796.txt item: #3 of 251 id: amj-474 author: Nadarajah, Natharubini title: Treatment of Rheumatoid Arthritis with Methotrexate Alone or A Combination of Methotrexate and Hydroxychloroquine date: 2015 words: 3324 flesch: 59 summary: Natharubini Nadarajah, Riardi Pramudyo, Kuswinarti, and Dr. Hasan Sadikin General Hospital Bandung conducted a retrospective cohort study on 46 patients with rheumatoid arthritis. The study found that there is no difference in the effectiveness of DMARD monotherapy with MTX and combination of MTX & HCQ. keywords: activity; age; ann; arthritis; bandung; clinic; combination; count; das28; data; disease; dmards; drugs; effectiveness; esr; general; group; hasan; hcq; hospital; hydroxychloroquine; joint; mean; medical; methotrexate; monotherapy; mtx; patients; record; response; results; rheumatoid; rheumatology; sadikin; sample; score; sjc; studies; study; table; therapy; tjc; treatment; years cache: amj-474.pdf plain text: amj-474.txt item: #4 of 251 id: amj-514 author: Rahhim, Nik Fatin Farhana Binti Mohd title: Distribution of Risks for Major Osteoporotic Fracture Based on Fracture Risk Assessment Tool in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia date: 2015 words: 3120 flesch: 52 summary: Osteoporosis is a growing public health problem in Indonesia. Rheumatoid arthritis, current smoking, prolonged glucocorticoids consumption and previous fracture are risk factors for osteoporotic fracture. The World Health Organization has developed a tool called Fracture Risk Assessment Tool to identify fracture risk based on the clinical risk factors. keywords: arthritis; assessment; bandung; bmd; bmi; bone; clinical; distribution; factors; fracture; frax; frequency; general; groups; hasan; hip; hospital; indonesia; low; major; mass; moderate; osteoporotic; percentage; previous; probability; respondents; rheumatoid; risk; sadikin; study; table; tool; total; years cache: amj-514.pdf plain text: amj-514.txt item: #5 of 251 id: aquichan-6401 author: Gómez-Ramírez, Olga Janneth title: Quality of life, perceived health status and sociodemographic factors among persons with rheumatoid arthritis date: 2017 words: 6334 flesch: 53 summary: Olga Janneth Gómez-Ramírez, Arlen Patricia and Olga J. Gomez-Gomez from the Universidad Nacional de Colombia discuss the relationship between the quality of life and the nivel of salud in personas with arthritis. keywords: acceso; actividad; acuerdo; afectación; ansiedad; análisis; aquichan; arthritis; articular; artritis reumatoide; asimismo; así; atención; años; cada; calidad; calidad de; calificación; capacidad; características; chía; colombia; como; con; con artritis; con el; con la; con los; consulta; correlacional; correlación; cual; cuando; cuenta; datos; daño; de la; de los; de salud; de un; de vida; del; depresión; desempeño; destreza; dificultades; dimensiones; disease; dolor; dominio; educativo; el nivel; elaboración; en el; en la; encontró; enfermedad; enfermería; entre; entrevista; eps; escala; escolaridad; esta; estado; estadísticamente; estadístico; este; estrato; estudio; está; et al; evidenció; factores; fenómeno; figura; forma; frecuencia; fuente; fueron; funcional; física; género; gómez; health; impact; importancia; instrumento; investigación; issn; janneth; junio; la enfermedad; la salud; la vida; las; las personas; las variables; life; los; manera; mayor; menor; modelo; movilidad; muestreo; mujer; mujeres; más; nivel; nivel de; nsp; olga; otro; pacientes; padilla; para; participantes; partir; path; percibido; personas; personas con; pessoas; población; por; positiva; promedio; propia; proporción; propuesta; qualidade; quality; que; que el; ramírez; realizó; reduce; reportado; respecto; resultados; reumatoide; reumatología; rheum; salud; salud percibido; salud y; saúde; seguridad; ser; significativamente; sin; social; sociodemográficos; socioeconómico; status; study; tabla; también; teórico; tipo; total; tratamiento; través; una; universidad; uso; variables; vida; vida y; vol; y de; y el; y la; y los; y nivel cache: aquichan-6401.pdf plain text: aquichan-6401.txt item: #6 of 251 id: bijps-1063 author: Abdul-Wahab, Farah K. title: Effects of Vitamin D3 on Methotrexate- Induced Jejunum Damage in Rats date: 2020 words: 5080 flesch: 47 summary: Farah K. Abdul-Wahab, Nada Nada Al-Shawi and their colleagues studied the effects of vitamin D3 on methotrexate-induced jejunum damage in rats. They found that the combination of the two drugs may be beneficial in the treatment of various diseases. keywords: abscess; antioxidant; atrophy; baghdad; cancer; capacity; cells; college; content; control; crypt; damage; days; degree; depletion; different; dose; effects; epithelial; exp; experimental; figure; fusion; goblet; goblet cells; group; group iii; group v; heavy; histopathological; homogenate; i.p; iii; induced; inflammation; inflammatory; inflammatory cells; injury; intestinal; iraqi; jejunum; jejunum damage; jejunum tissue; lamina; level; mda; med; metabolism; methotrexate; methotrexateinduced; mild; mixed; moderate; mtx; normal; oxidative; p<0.05; pharm; propria; protective; ratio; rats; role; sci; severe; significant; single; small; stress; studies; study; taoc; tissue; total; toxicity; treatment; university; vii; villi; villous; vitamin; vitamin d3; vol.29(1; widening cache: bijps-1063.pdf plain text: bijps-1063.txt item: #7 of 251 id: bijps-1590 author: Mohammed, Samer Imad title: The Effect of TNF-Alpha Gene Polymorphisms At -376 G/A, -806 C/T, and -1031 T/C on The Likelihood of Becoming a Non-Responder to Etanercept in A Sample of Iraqi Rheumatoid Arthritis Patients date: 2022 words: 8909 flesch: 58 summary: Eighty RA patients on Etanercept for at least six months were recruited from the Rheumatology Unit at Baghdad Teaching Hospital. After polymerase chain reaction, the amplified DNA was sequenced by Sanger method to determine the genetic polymorphisms at the positions -376 G/A, -806 C/T, and -1031 T/C. There was no significant association between the polymorphisms in the TNF-Alpha gene promoter region and the tendency for non-responding to ETN. keywords: -1031; -1031 t; -308; -376; -376 g; -806; activity; allele; alpha; alpha gene; amplification; analysis; annealing; antagonists; anti; arthritis; arthritis patients; associated; association; available; baghdad; blood; carriers; change; characteristics; clinical; college; concentration; correlation; criteria; current; das28; data; demographic; difference; disease; dna; effect; et al; etanercept; etn; eular; factor; figure; findings; frequencies; gene; gene polymorphisms; genetic; genotypes; group; high; https://; human; indicative; influence; internet; iraqi; iraqi j; j pharm; joints; jul; kang; level; likelihood; mar; means; med; months; necrosis; necrosis factor; non; nucleotide; patients; pcr; pharm; polymorphic; polymorphisms; population; presence; primer; promoter; ra patients; region; research; responders; response; responsiveness; results; rheumatoid; rheumatoid arthritis; rheumatology; role; rs1799964; rs1800750; rs4248158; sample; sanger; sci; score; serum; significant; single; sites; size; snps; statistical; studies; study; susceptibility; table; temperature; tendency; test; therapy; tnf; treatment; tumor; value; variant; vol.31(2; α gene; التهاب; الجيني; الرثوي; المفاصل; بغداد; على; نخر cache: bijps-1590.pdf plain text: bijps-1590.txt item: #8 of 251 id: bijps-381 author: A. Nadhum, Shams title: Design, Synthesis, Characterization and Preliminary Anticancer Study for Methotrexate Silibinin Conjugates date: 2017 words: 4856 flesch: 55 summary: Methotrexate (MTX) is used in the treatment of certain cancers, severe psoriasis and rheumatoid arthritis. It is also used to target cancer cells resistant to anticancer drugs. Shams A. Nadhum, Nadhum and Mohammed H. Mohammed from the College of Pharmacy, University of Baghdad, studied the synthesis of two derivatives of MTX. keywords: 5,6; acid; activity; agents; amide; amino; analysis; anticancer; assay; benzen; cancer; cell; characterized; chem; compound; concentration; conjugates; culture; cytotoxic; derivative; different; drop; drug; effective; elemental; evaluation; exposure; folate; hcl; high; human; inhibition; iraqi; low; mechanisms; membrane; methotrexate; methotrexate silibinin; methyl; mixture; mtx; n h; n n; n o; new; nh3cl; nmr; oho; p.s; pharm; powder; prodrug; proliferation; promising; rate; receptor; resistance; results; sci; silibinin; socl2; solvent; spectroscopy; stirred; stretching; surface; synthesis; table; target; tissue; treatment; triethylamine; tumor; vibration; vol.24(1; wise; yellow; اٌسشطأُح cache: bijps-381.pdf plain text: bijps-381.txt item: #9 of 251 id: bijps-396 author: M. Mikhael, Ehab title: Evaluation of Rosuvastatin Effect as Adjuvant Therapy to Methotrexate on Lipid Profile and the Possibility of its Cardioprotective Effect in Iraqi Patients with Active Rheumatoid Arthritis date: 2017 words: 3880 flesch: 46 summary: Rosuvastatin is an anti-inflammatory drug used as an adjuvant therapy to methotrexate. 40 active rheumatoid arthritis patients with active RA were randomized into 2 groups to receive either rosuvastatin 10mg or a placebo as an adjuvant to MTX. Lipid profile and erythrocyte sedimentation rate (ESR) was assessed at the start and at the end of the study. After 8 weeks of treatment, the study found that the drug significantly reduced ESR, TC and LDLc. keywords: active; adjuvant; ann; arthritis; baghdad; baseline; cardioprotective; cardiovascular; cholesterol; clin; continuous; control; density; difference; disease; early; effect; esr; et al; group; hdlc; high; higher; inflammation; inflammatory; iraqi; laboratory; ldlc; level; lipid; lipoprotein; low; methotrexate; mtx; normal; patients; pbo; pharm; placebo; profile; ra patients; randomized; range; reductase; results; rheumatoid; rheumatoid arthritis; risk; rosuvastatin; sci; significant; study; subjects; table; test; therapy; total; treatment; values; variables; vol.23(1; weeks; انشثٕ٘; انًفاصم; ػُذ cache: bijps-396.pdf plain text: bijps-396.txt item: #10 of 251 id: bijps-411 author: M. Mikhael, Ehab title: Neutrophil / Lymphocyte Ratio is not Correlated with Disease Activity in Rheumatoid Arthritis Patients date: 2017 words: 3217 flesch: 33 summary: Neutrophil lymphocyte ratio (NLR) is a measure of inflammation in many diseases. 24 patients with active rheumatoid arthritis participated in this study. NLR was positively correlated with ESR and inversely correlated with Hb. keywords: active; activity; arthritis; assessment; baghdad; blood; cardiovascular; clinical; correlation; count; crp; das28; disability; disease; disease activity; ega; esr; finding; haqdi; health; heart; hematological; index; inflammation; iraqi; joints; liter; lymphocyte; measure; mtx; nano; neutrophil; nlr; parameters; patients; pharm; protein; ratio; rbc; reactive; rheumatoid; rheumatoid arthritis; risk; sci; score; sdai; significant; sjc; study; systemic; table; vas; vol.22(2; wbc; انثٛط; انذو; انًفاصم; كشٚاخ; َسثح cache: bijps-411.pdf plain text: bijps-411.txt item: #11 of 251 id: bijps-449 author: K. Mohammed Salih, Raya title: The Correlation Between Hyperglycemia and Rheumatoid Factor in Type 2 Diabetic Patients in Al- Risafa Area, Baghdad date: 2017 words: 5394 flesch: 69 summary: There is a positive correlation between hyperglycemia and rheumatoid factor (RF) in type 2 diabetes mellitus (T2DM) patients living in Al-Risafa area -Baghdad. The highest percentage of titer observed with 34.1% in those with RF titer 64 IU/ml when compared with healthy control. keywords: age; agglutination; arthritis; baghdad; bmi; care; chronic; class; clin; comparison; control; diabetes; diabetic; diabetic patients; diseases; distribution; dm patients; factor; female; fpg; glucose; groups; healthy; highest; hyperglycemia; important; index; inflammatory; insulin; iraqi; iu/; level; mass; mellitus; mmol; negative; niddm; non; normal; number; obese; overweight; patients; percent; percentage; pharm; plasma; positive; prevalence; pro; resistance; results; rf positive; rf titer; rheumatoid; rheumatoid arthritis; rheumatoid factor; risk; role; sci; serum; significant; smokers; smoking; study; subjects; t2 dm; table; test; titer; total; type; value; vol.21(1; years; أظٓش; انسكش٘; انشث; انؼايم; اًن; دسجح; ٕاَٙ cache: bijps-449.pdf plain text: bijps-449.txt item: #12 of 251 id: bijps-459 author: MA. Naji, Zahraa title: Uric Acid as a Natural Scavenger of Peroxynitrite in a Sample of Iraqi Patients with Rheumatoid Arthritis date: 2017 words: 3511 flesch: 55 summary: Zahraa MA. Naji, Shaimaa M.Mohammed, Mays F. Muhammad and 25 healthy controls were included in the case-controlled study conducted at Baghdad teaching hospital from December 2010-May 2011. The serum levels of nitric oxide (NO), peroxynitrite (PN), malondialdehyde (MDA) and uric acid (UA) were found to be higher in RA patients than in controls. keywords: acid; activity; age; antioxidant; arthritis; baghdad; blood; chronic; control; damage; decrease; disease; et al; free; group; healthy; human; increase; inflammation; inflammatory; iraqi; levels; lipid; malondialdehyde; mda; mean; mean±se; natural; nitration; nitric; oxidative; oxide; oxygen; patients; peroxidation; peroxynitrite; pharm; plasma; production; radicals; range; rate; reactive; rheumatoid; rheumatoid arthritis; role; scavenger; sci; sedimentation; serum; significant; species; status; stress; study; subjects; superoxide; uric; uric acid; van; vol.21(2; years; اىذساست; اىَشظٚ; اىٞ٘سٝل; ىذٙ; ٍعذالث cache: bijps-459.pdf plain text: bijps-459.txt item: #13 of 251 id: bijps-462 author: J.Nasser, Saddam title: Preparation and Evaluation of Oral Disintegrating Tablets of Ketoprofen by Dirct Compression date: 2017 words: 2993 flesch: 52 summary: Saddam J.Nasser, Laith Sameen, Mowafaq M.Ghareeb, and others prepared oral disintegrating tablets of Ketoprofen by direct compression method. Formula F11 batch had short disintegration time (18.0 sec) with good physical properties. keywords: absorption; angle; british; ccs; compliance; compression; content; conventional; different; direct; disintegration; dissolution; dissolving; dosage; drug; evaluation; f11; fast; forms; formula; formulation; friability; good; hardness; international; iraqi; journal; ketoprofen; medium; method; mouth; oral; orodispersible; parameters; passable; patel; pharm; pharmacopoeia; powder; prepared; properties; rapid; repose; sci; sodium; subliming; superdisintegrants; tablets; technique; time; vol.21(2; water; weight; wetting cache: bijps-462.pdf plain text: bijps-462.txt item: #14 of 251 id: bijps-464 author: M. Ali, Huda title: Evaluation of Trace Elements in Iraqi Patients with Rheumatoid Arthritis by using Atomic Absorption Spectrophotometer (AAS) date: 2017 words: 4925 flesch: 50 summary: Trace elements were determined by atomic absorption spectrophotometer (AAS) in blood serum of 30 patients with rheumatoid arthritis, 14 male and 16 female with age range (37-60 years) compared with normal control. The mean levels of Zinc, Copper, Selenium, Magnesium, Manganese, Chromium, Iron, Nickel, Cobalt, Vanadium and Germanium were significantly lower than controls. There were no significant differences in trace elements levels in relation to sex. keywords: absorption; anemia; antioxidant; arthritis; atomic; blood; body; bone; cell; chromium; clinical; cobalt; concentration; control; copper; damage; data; decrease; deficiency; development; difference; disease; effect; elements; enzyme; essential; factor; female; figure; formation; free; function; germanium; group; growth; health; high; histogram; human; immune; important; inflammatory; iraqi; iron; levels; magnesium; manganese; mean; metabolism; necessary; nickel; oxidative; p<0.001; patients; people; pharm; production; results; rheumatoid; rheumatoid arthritis; role; sci; selenium; sera; serum; significant; spectrophotometer; studies; study; system; table; trace; trace elements; values; vanadium; vitamin; vol.21(2; zinc; اىعْاصش cache: bijps-464.pdf plain text: bijps-464.txt item: #15 of 251 id: bijps-504 author: G. Sabar, Ahmed title: Lithotripsy of Different Urinary Tract Stones by Using Seeds of Carum copticum date: 2017 words: 2425 flesch: 60 summary: Iraqi J Pharm Sci, Vol.19(2) 2010. Ahmed Sabar used Carum copticum seeds to treat urinary stones. 350 patients took part in the research. The treatment was effective against Ca-Oxalate stone. keywords: acid; ammi; analysis; ayurvedic; carum; carum copticum; chemical; copticum; days; different; dose; effect; essential; extract; h.s; india; iraqi; kidney; liquid; lithotripsy; mixed; oil; oxalate; patients; pharm; plant; preparation; present; pure; renal; research; response; results; sci; seeds; stone; study; table; thymol; trachyspermum; tract; treatment; types; urinary; use; vol.19(2; اٌٝ; ٘ذا cache: bijps-504.pdf plain text: bijps-504.txt item: #16 of 251 id: bijps-533 author: S. Manhal, Falah title: Frequency of Antineutrophil Cytoplasmic Antibodies (ANCA) in Some Autoimmune Diseases date: 2017 words: 3902 flesch: 61 summary: Antineutrophil Cytoplasmic Antibodies (ANCA) are a heterogeneous group of autoantibodies with a broad spectrum of clinically associated diseases. They are important factors for the clinical course and prognosis in the patients with autoimmunity. keywords: activity; age; anca; anti; antibodies; antibody; antineutrophil; arthritis; autoantibodies; autoimmune; clinical; colitis; control; cytoplasmic; diagnostic; differences; diseases; disorders; elisa; erythematosus; frequency; group; healthy; immunofluorescence; iraqi; levels; lupus; mean; mpo; non; normal; patients; pharm; positive; pr3; results; rheumatoid; role; sci; sera; serum; sig; significance; sle; studies; study; suppl; systemic; table; testing; ulcerative; value; vasculitis; vol.18(2; ااا; ااة; ااةن; اام; فام; يطم cache: bijps-533.pdf plain text: bijps-533.txt item: #17 of 251 id: bijps-545 author: M. Muhammad, Hazhar title: Quantitative and Qualitative Analysis of Plumbagin in the Leaf and Root of Plumbago europaea Growing Naturally in Kurdistan by HPLC date: 2017 words: 2016 flesch: 56 summary: Plumbago europaea is a genus of 10-20 species of flowering plants used in traditional Indian medicine. Plumbago roots have been used for the treatment of cancer, rheumatoid arthritis, and dysmenorrhea. HPLC analysis of plumbagin in the roots and leaves extracts was carried out by HPLC technique. keywords: active; analysis; calibration; concentration; constituent; curve; europaea; extracts; figure; genus; hplc; iraqi; isolated; leaf; leaves; main; major; nmr; pharm; plant; plates; plumbagin; plumbago; plumbago europaea; quantitative; roots; sci; species; spectrum; standard; suppl; tlc; vol.18 cache: bijps-545.pdf plain text: bijps-545.txt item: #18 of 251 id: bijps-684 author: A. Hazzaa, Suray title: Formulation and Evaluation of Optimized Zaltoprofen Lyophilized Tablets by Zydis Technique date: 2017 words: 4946 flesch: 50 summary: Zaltoprofen is used in the treatment of rheumatoid arthritis and osteoarthritis. It is also used to relieve inflammation and pain after surgery, injury, injury and tooth extraction. Suray Hazzaa, Shaimaa Abd-Alhameed, and others studied the lyophilized disintegrating tablets prepared using Zydis technique. They found that the formula containing 3.2%, 3.3%, mannitol, glycine, 1.5%, PVP K30 and 1% was the most suitable. keywords: .the; 0.1n; agent; blister; brittle; buffer; bulking; calibration; characterization; collapse; concentration; design; determination; different; diffraction; disintegration; dissolution; distilled; drug; drying; effect; evaluation; excipients; f14; fast; figure; formulas; formulation; freeze; ftir; gelatin; glycine; good; handling; hcl; high; increase; iraqi; j pharm; journal; lyophilization; lyophilized; mannitol; matrix; max; mechanical; medium; melting; method; oral; parameters; pharm; pharmaceutical; pharmacy; phosphate; physical; point; powder; prepared; properties; protectant; rate; ray; release; results; sci; solubility; sorbitol; study; tablets; technique; temperature; test; time; vivo; vol.26(1; water; weight; zaltoprofen; zydis; اُحبىب; اُذواء cache: bijps-684.pdf plain text: bijps-684.txt item: #19 of 251 id: bijps-932 author: Faiq, Mirna K. title: The Belief about Medicines among a Sample of Iraqi Patients with Rheumatoid Arthritis date: 2019 words: 4395 flesch: 56 summary: Belief about medicines among Iraqi patients with rheumatoid arthritis was measured via the Arabic version of the Beliefs about Medicines Questionnaire. The majority of the patients (88%) had strong beliefs in the necessity of treatment. keywords: activity; adherence; age; analysis; arthritis; articular; association; baghdad; beliefs; bmq; cdai; chronic; clinical; coefficient; college; concern; correlation; current; das28; department; direct; disease; duration; esr; factors; female; gender; general; greater; harm; high; index; iraqi; journal; mean; medication; medicines; necessity; number; overuse; patients; pharmacy; positive; pvalue; questionnaire; regression; relationship; rheumatoid; rheumatoid arthritis; rheumatology; sample; sci; score; significant; specific; strong; study; subject; table; treatment; university; use; variables; vol.28(2; years; االدوية; التهاب; الرثوي; العالج; المعتقدات cache: bijps-932.pdf plain text: bijps-932.txt item: #20 of 251 id: biomedich-90 author: Erhirhie, Earnest Oghenesuvwe title: Antioxidant Activities of the Leaf Extract and Fractions of Dryopteris filix-mas (L.) Schott could be Attributed to The Abundance of Polyphenol Compounds date: 2020 words: 3920 flesch: 48 summary: Dryopteris filix mas (D filix-mas) is used in ethnomedicine for the management of rheumatoid arthritis, wounds and other diseases. Researchers studied the anti-oxidant activities of its leaf extract and chromatographic fractions. The ethyl acetate fraction produced the highest free radical scavenging activity. keywords: 2014; acetate; acid; activities; activity; antioxidant; ascorbic; assay; butanol; compound; concentration; diseases; dpph; dryopteris; erhirhie; et al; ethyl; extract; faculty; ferric; filix; flavonoids; fractions; frap; free; ic50; inhibition; isolated; leaf; leaves; mas; mean; medicinal; natural; nigeria; nitric; oxidative; oxide; pharmaceutical; phenolic; plant; power; properties; quercetin; radicals; res; scavenging; sciences; sph; study; table; university; values; vlc cache: biomedich-90.pdf plain text: biomedich-90.txt item: #21 of 251 id: bjos-8656652 author: Alfenas, Bruna Fernandes Moreira title: Removable prostheses improve OHRQL and satisfaction of elderly people with rheumatoid arthritis date: 2020 words: 5104 flesch: 53 summary: Renata Cunha, Matheus Rodrigues, Kelly Machado, De Andrade, Talita Malini Carletti, and Bruno Fernandes Moreira Alfenas are the authors of the study on the oral rehabilitation with conventional dentures in elderly people with rheumatoid arthritis. They found that the use of new and well-fitted dentures improves all domains of OHRQoL in patients with RA and TMD. keywords: alfenas; arthritis; associated; autoimmune; better; clinical; complete; control; conventional; criteria; dental; dentures; diagnosis; disadvantages; discomfort; disease; disorders; doi; domains; elderly; experimental; functional; general; group; health; impact; incapacity; insertion; interaction; joints; level; life; limitation; lower; masticatory; mean; mouth; n=15; new; ohrqol; old; oral; pain; partial; patients; paulo; people; perception; physical; piracicaba; point; presence; prostheses; prosthetic; psychological; quality; rehabilitation; removable; results; review; rheumatoid; rheumatology; satisfaction; score; significant; social; study; são; table; teeth; temporomandibular; test; time; tmd; treatment; use; values; volunteers cache: bjos-8656652.pdf plain text: bjos-8656652.txt item: #22 of 251 id: brain-956 author: Subtirelu, Mihaela Simona title: Cultural Adaptation and Optimization of the Compliance Questionnaire-Rheumatology (CQR) Through Statistical Methods for Patients with Rheumatic Diseases date: 2019 words: 5992 flesch: 53 summary: There is a growing interest in the management of long-term conditions and increasing awareness of the need for compliance/adherence's assessment. The aim of the study is to increase the quality of assessment of patients’ compliance through statistical methods in order to obtain a more accurate estimation and a shorter, easy-to-respond self-administered questionnaire. keywords: adaptation; adherence; analysis; anti; compliance; component; consistency; conventional; correlation; cqr; cqr19; craiova; cronbach; cultural; data; der; deviation; different; diseases; drugs; factors; faculty; final; good; health; internal; items; measure; medication; medicines; methods; neamtu; new; number; optimization; patients; petru; pharmacy; phone; q19; questionnaire; questions; reliability; research; rheumatic; rheumatology; romania; score; standard; statistical; stiolica; str; study; subtirelu; table; treatment; turcu; university; value; van; variables; version; vreju cache: brain-956.pdf plain text: brain-956.txt item: #23 of 251 id: chimtech-1188 author: Savateev, K. V. title: 6-Aminotriazolo[1,5-a]pyrimidines as precursors of 1,2,4-triazolo[5,1-b]purines date: 2015 words: 912 flesch: 79 summary: Savateev, Borisov, Voinkov, Ulomsky, Rusinov, Chupakhin, and others studied the synthesis of triazolopurines at the Institute of Organic Synthesis Ural Division of RAS in Ekaterinburg. keywords: a]pyrimidines; b]purines; borisov; chupakhin; doi; rusinov; savateev; synthesis; ulomsky; voinkov; zhao; борисов; воинков; нами; синтеза; уломский cache: chimtech-1188.pdf plain text: chimtech-1188.txt item: #24 of 251 id: cord-0001164-64p3wpav author: Huang, Shang-Hui title: Self-Oligomerization Is Essential for Enhanced Immunological Activities of Soluble Recombinant Calreticulin date: 2013 words: 5266 flesch: 46 summary: Calreticulin (CRT) can be found in the sera of patients with rheumatoid arthritis and with SLE. CRT fragments 18-412 can self-oligomerize in solution and are 50-100 times more potent than native CRT in activating macrophages in vitro. The active site of CRT is between residues 150-230. keywords: 37uc; able; abs; activation; active; activities; activity; analysis; anti; binding; buffer; calreticulin; cells; chaperone; column; concentration; cp32; crt; domain; fig; figs; fitc; form; gel; higher; human; hypothesis; ias; igg; immune; immunization; immunological; kda; lectin; lps; macrophages; mice; min; molecular; monomeric; motif; mouse; nacl; ncrt; oligomerization; oligomers; orcrts; page; pbs; polypeptides; potent; production; protein; rabbit; rcrt/120; rcrt/18; rcrt/39; recombinant; residues; responses; results; sds; self; sequence; site; soluble; strong; surface; type; usa; weight cache: cord-0001164-64p3wpav.txt plain text: cord-0001164-64p3wpav.txt item: #25 of 251 id: cord-0001353-0zsn4lu3 author: Lee, Yu-Ching title: Isolation, Characterization, and Molecular Modeling of a Rheumatoid Factor from a Hepatitis C Virus Infected Patient with Sjögren's Syndrome date: 2013 words: 5169 flesch: 49 summary: RFL11 is an IgG rheumatoid factor from a Hepatitis C virus infected patient with Sjögren's syndrome. RFL11 has a high binding affinity of about 6 × 10(−8) M. keywords: affinity; amino; analysis; antibodies; antibody; antigen; arthritis; autoimmune; bonding; cdr; cdrs; chain; clones; complex; different; diseases; dna; epitope; fab; figure; fragment; gene; hcv; heavy; hepatitis; high; homology; human; igg; igg fc; igm; infection; interactions; interface; isolated; libraries; library; light; loop; model; mutation; panning; pathogenic; patients; pbst; phage; protein; region; residues; results; rf61; rfl11; rfs; rheumatoid; room; sequence; sigma; similar; sjögren; somatic; specificity; structure; study; syndrome; temperature; virus cache: cord-0001353-0zsn4lu3.txt plain text: cord-0001353-0zsn4lu3.txt item: #26 of 251 id: cord-0001647-0zkeoa1z author: ten Oever, Jaap title: The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases date: 2014 words: 4627 flesch: 43 summary: TLR2 and sTLR4 are released into the circulation during inflammation. They can be used as a diagnostic biomarkers. CRP is better at distinguishing bacterial infections from viral infections. TLR2 correlated positively with TNF-AUC and negatively with IL-10. keywords: amniotic; analysis; arthritis; auc; autoinflammatory; bacterial; biomarkers; blood; cd14; cell; concentrations; conditions; correlation; crp; cytokine; diagnostic; diseases; endotoxemia; expression; figure; fluid; group; healthy; hours; human; il-1ra; il-6; immune; important; infections; inflammation; inflammatory; levels; like; lps; monocytes; negative; non; patients; plasma; present; receptors; release; samples; sensitivity; sepsis; signaling; soluble; solution; stimulation; stlr2; study; surface; table; tlr4; tlrs; toll; value; viral cache: cord-0001647-0zkeoa1z.txt plain text: cord-0001647-0zkeoa1z.txt item: #27 of 251 id: cord-0001828-navjkevd author: Zhang, Xiaoqing title: Designation of a Novel DKK1 Multiepitope DNA Vaccine and Inhibition of Bone Loss in Collagen-Induced Arthritic Mice date: 2015 words: 4145 flesch: 48 summary: Dickkopf-1 (DKK1) is an inhibitor of canonical Wnt signaling, which plays a critical role in certain bone loss diseases. The serum levels of DKK1 are significantly higher in rheumatoid arthritis (RA) patients and are correlated with the severity of the disease. In this study, Zhang, Xiaoqing, Liu, Sibo, Li, Shentao, Du, Yuxuan, Dou, Yunpeng, Li Zhanguo, Yuan, Huihui, Zhao, Wenming developed a DNA vaccine targeted against DKK 1 to prevent bone erosion in CIA mice. keywords: addition; antibodies; antibody; antigen; arthritis; balb; bone; bovine; cell; control; cos7; delivery; disease; dkk1; dna; dna vaccine; epitopes; erosion; expression; figure; gene; goat; group; high; human; immunization; immunogenicity; injection; mice; mouse; multiepitope; patients; pcmv; peptides; plasmid; plates; protein; r&d; recombinant; rheumatoid; role; serum; software; specific; systems; times; treatment; usa; vaccine; vitro; vivo; week; wnt cache: cord-0001828-navjkevd.txt plain text: cord-0001828-navjkevd.txt item: #28 of 251 id: cord-0002114-scbku3ce author: Cheng, Brian Chi Yan title: A herbal formula comprising Rosae Multiflorae Fructus and Lonicerae Japonicae Flos, attenuates collagen-induced arthritis and inhibits TLR4 signalling in rats date: 2016 words: 3937 flesch: 41 summary: RL is a traditional remedy for Rheumatoid Arthritic arthritis (RA). It is a herbal formula composed of Rosae Multiflorae Fructus and Lonicerae Japonicae Flos. It is well established for studying human RA. In the present study, we investigated the in vivo efficacy of RL in CIA rats. It significantly increased food intake and weight gain of CIA rats without any observable adverse effect. It ameliorated joint erythema and swelling, inhibited immune cell infiltration, bone erosion and osteophyte formation in joints, reduced joint protein expression levels of TLR4, phospho-TAK1 and p65. It reinvigorated activities of antioxidant keywords: activation; activities; adverse; anti; antioxidant; arthritis; bone; cells; chinese; cia; cia rats; clinical; collagen; conditions; cytokines; day; effects; fig; food; formula; groups; herbal; herbs; hind; histological; hong; il-17; il-6; immune; inflammatory; inhibit; inhibited; irf3; joint; kong; levels; like; mice; normal; pathways; paw; phospho; production; rats; receptor; responses; rheumatoid; role; sera; serum; signalling; splenocytes; study; swelling; tak1; th17; tissues; tlr4; tnf; toll; type; usa cache: cord-0002114-scbku3ce.txt plain text: cord-0002114-scbku3ce.txt item: #29 of 251 id: cord-0002395-9a163ad7 author: Zhang, Li title: A Rationally Designed TNF-α Epitope-Scaffold Immunogen Induces Sustained Antibody Response and Alleviates Collagen-Induced Arthritis in Mice date: 2016 words: 4860 flesch: 44 summary: The TNF-α biological inhibitors have improved the clinical outcomes of many autoimmune diseases. However, practical uses are limited due to high costs and the risk of anti-drug antibody responses. In the present study, the authors designed a T NF-α epitope-scaffold immunogen DTNF7 using the transmembrane domain of diphtheria toxin. In a mouse model of rheumatoid arthritis, the vaccination markedly delayed the onset of collagen-induced arthritis. keywords: alpha; alum; animal; antibodies; antibody; arthritis; autoimmune; carrier; cell; cia; clinical; collagen; conformation; csf; cytokine; data; day; design; diphtheria; diseases; distance; domain; dtnf7; dtt; end; epitope; factor; fig; function; group; helper; human; immune; immunization; immunogen; immunogenicity; inflammatory; interatomic; mice; model; molecule; mouse; native; necrosis; peptide; position; proteins; purified; replaced; residues; response; rheumatoid; scaffold; score; specific; stability; stable; structure; swelling; therapeutic; tnf; toxin; transplantation; treatment; tumor; type; universal; vaccination; vaccine cache: cord-0002395-9a163ad7.txt plain text: cord-0002395-9a163ad7.txt item: #30 of 251 id: cord-0002419-5h6monh3 author: Lee, Seung Hoon title: PTEN ameliorates autoimmune arthritis through down-regulating STAT3 activation with reciprocal balance of Th17 and Tregs date: 2016 words: 4161 flesch: 41 summary: PTEN is a tyrosine phosphatase with significant function in inhibiting STAT3 activation. The expression of PTEN controlled by p53 regulates autoimmune arthritis through modulating the balance between Th17 and Treg cells. Overexpression of the PTEN gene significantly reduced the degree of inflammation, bone damage and cartilage damage in CIA mice. keywords: activation; activity; analysis; antibodies; arthritis; autoimmune; balance; cd4; cells; cia; collagen; confocal; cytokines; damage; data; deficiency; development; differentiation; experimental; expression; factor; fig; foxp3; gene; human; il-17; independent; inflammation; inflammatory; levels; loss; mice; mock; mrna; number; overexpression; p53; patients; production; pten; reciprocal; regulation; response; results; rheumatoid; role; severity; spleen; splenocytes; stat3; study; suppressor; th17; therapeutic; tissues; tolerance; treg; tumor; usa; vector cache: cord-0002419-5h6monh3.txt plain text: cord-0002419-5h6monh3.txt item: #31 of 251 id: cord-0002445-x4na1o4p author: Fan, Zhi-Dan title: Involvement of P2X7 receptor signaling on regulating the differentiation of Th17 cells and type II collagen-induced arthritis in mice date: 2016 words: 6068 flesch: 39 summary: P2X7 receptor regulates the differentiation of Th17 cells and type II collagen-induced arthritis in mice. It is an ATP-gated ion channel belonging to P2 receptors. It inhibited hind paw swelling and ameliorated pathological changes in ankle joint of the mice. keywords: a-438079; activation; addition; analysis; antagonists; anti; arthritis; atp; atp release; cd4; cell differentiation; cells; changes; cia; cii; coculture; collagen; controls; csf; cultured; cytokines; data; dcs; development; differentiation; effect; expression; extracellular; fig; findings; function; human; il-12p35; il-12p40; il-17a; il-1β; il-6; immune; important; inflammation; inflammatory; inhibition; joint; levels; mice; mrna; novel; p2x7r; patients; potential; production; receptor; regulation; regulatory; release; response; results; rheumatoid; role; rorα; rorγ; signaling; stimulation; study; suramin; synovial; system; t cells; tgf; th17; th17 cell; therapeutic; treatment; type; usa; vivo cache: cord-0002445-x4na1o4p.txt plain text: cord-0002445-x4na1o4p.txt item: #32 of 251 id: cord-0002486-p7duonkr author: Lin, Ze-Min title: Artemisinin analogue SM934 attenuate collagen-induced arthritis by suppressing T follicular helper cells and T helper 17 cells date: 2016 words: 5066 flesch: 39 summary: Artemisinin analogue SM934 attenuates collagen-induced arthritis by suppressing T follicular helper cells and T helper 17 cells. It also suppresses the production of pathogenic antibodies without altering the proportion of germinal center B cells. keywords: activation; analysis; animal; anti; antibodies; antibody; antigen; artemisinin; arthritis; autoimmune; bcl-6; bone; c57bl/6; cd4; cells; center; cia; cia mice; cii; collagen; costimulatory; cultured; cytokines; days; dba/1j; derivatives; development; differentiation; effect; expansion; expression; fig; follicular; formation; generation; germinal; groups; helper; il-17; il-21; immunized; inflammatory; levels; lupus; mice; model; mouse; naïve; normal; novel; ova; pathogenesis; plasma; production; proliferation; responses; rheumatoid; role; saline; serum; severity; signaling; signals; sm934; specific; splenocytes; srbc; stat3; t cells; tfh; th17; therapeutic; treatment; vivo cache: cord-0002486-p7duonkr.txt plain text: cord-0002486-p7duonkr.txt item: #33 of 251 id: cord-0002549-8xndud0h author: Lin, Bo title: Expression and bioactivity of human α-fetoprotein in a Bac-to-Bac system date: 2017 words: 4154 flesch: 53 summary: The present study is the first to report a high yield of recombinant human AFP in a Bac-to-Bac system. The method can produce high yields of R-AFP, which can be used for studies related to AFP. The results indicated that R- AFP promoted the growth of hepatoma cells. keywords: afp; afpr; alpha; anti; antibody; bac; baculovirus; bel; binding; buffer; cancer; cells; chromatography; concentration; cytoplasmic; drug; effects; expression; fetoprotein; figure; growth; hbs; human; human afp; infection; insect; line; medium; membrane; min; page; present; production; proliferation; protein; purification; purified; receptor; recombinant; results; sds; similar; study; supernatant; system; time; u.s.a; volume; yield cache: cord-0002549-8xndud0h.txt plain text: cord-0002549-8xndud0h.txt item: #34 of 251 id: cord-0003075-ki94q4qv author: Louis, Cynthia title: TANK-Binding Kinase 1-Dependent Responses in Health and Autoimmunity date: 2018 words: 8906 flesch: 27 summary: The pathogenesis of autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), is driven by genetic predisposition and environmental triggers that lead to dysregulated immune responses. Therapies that target the germinal center (GC) reaction and antibody-secreting plasma cells (PC) could provide a novel approach. keywords: activation; activity; affinity; aging; akt; antibody; antigen; antiviral; arthritis; atg5; atg7; autoantibodies; autoantibody; autoimmune; autoimmunity; autophagy; b cells; bcl6; cd4; cells; cellular; center; class; clearance; contribute; cre; cytokines; cytoplasmic; dcs; defective; deficiency; deletion; dependent; development; differentiation; disease; dna; effector; erythematosus; essential; expression; follicular; formation; foxo1; function; generation; germinal; helper; hematopoietic; high; homeostasis; humoral; icos; ifn; ifnar; immune; impaired; inducible; induction; infection; inflammation; inflammatory; inhibition; innate; interferon; irf3; kinase; like; lived; long; lupus; macrophages; maintenance; maturation; memory; mice; mitophagy; models; mutations; pathogenic; pathway; patients; phenotype; phosphorylation; plasma; population; potential; production; proteins; reaction; receptor; reduced; responses; review; role; signaling; sle; specific; spontaneous; sting; studies; survival; syndrome; systemic; t cells; tank; tbk1; tfh; therapies; tnf; trex1; type; −/− cache: cord-0003075-ki94q4qv.txt plain text: cord-0003075-ki94q4qv.txt item: #35 of 251 id: cord-0004029-q8e08pq0 author: Smatti, Maria K. title: Viruses and Autoimmunity: A Review on the Potential Interaction and Molecular Mechanisms date: 2019 words: 6530 flesch: 28 summary: There are more than 80 types of autoimmune disorders. Multiple factors have been linked to autoimmune responses, including genetics, age, environment, as well as viral infections. Virus-induced autoimmunity can be activated through multiple mechanisms, including molecular mimicry, epitope spreading, bystander activation, and immortalization of infected B cells. keywords: activation; analysis; antibodies; antigens; associated; association; autoimmune; autoimmunity; autoreactive; barr; beta; blood; bystander; case; cells; childhood; children; clinical; cns; contribution; coxsackie; cross; cvb; cvb4; development; diabetes; diabetic; disease; disorders; early; ebv; enterovirus; epstein; erythematosus; evidence; expression; factors; h1n1; hepatitis; herpes; herpesviruses; high; human; iav; ifn; induced; induction; infected; infection; inflammation; influenza; islet; lupus; mechanisms; mice; mimicry; model; molecular; multiple; narcolepsy; non; onset; pancreatic; pandemic; pathogenesis; patients; potential; protective; proteins; receptor; response; review; risk; role; rotavirus; rubella; sclerosis; self; simplex; specific; spreading; studies; study; suggested; susceptible; systemic; trigger; type; vaccine; viral; virus; viruses cache: cord-0004029-q8e08pq0.txt plain text: cord-0004029-q8e08pq0.txt item: #36 of 251 id: cord-0005807-bi1tqa7e author: Saklatvala, J. title: Tumour necrosis factor α stimulates resorption and inhibits synthesis of proteoglycan in cartilage date: 1986 words: 1975 flesch: 45 summary: Saklatvala, J. and Shaikh report that recombinant human TNFa stimulates resorption and inhibits synthesis of proteoglycan in explants of cartilage. TNF is a second macrophage-derived cytokine whose production in rheumatoid arthritis could contribute to tissue destruction. keywords: arthritis; bovine; cartilage; cells; chondroitin; culture; cytokine; effects; experiments; fragments; human; il-1; inflammatory; leukocytes; maximal; medium; papain; porcine; production; proteoglycan; release; resorption; rheumatoid; similar; sulphate; synthesis; tissue; tnfa; tnfs cache: cord-0005807-bi1tqa7e.txt plain text: cord-0005807-bi1tqa7e.txt item: #37 of 251 id: cord-0006470-yqh4exz0 author: Aruoma, Okezie I. title: Free radicals, oxidative stress, and antioxidants in human health and disease date: 1998 words: 7183 flesch: 31 summary: Free radicals and other reactive oxygen species (ROS) are constantly formed in the human body. Free-radical mechanisms have been implicated in the pathology of several human diseases, including cancer, atherosclerosis, malaria, rheumatoid arthritis and neurodegenerative diseases. Antioxidant defenses to remove O(2)(·−) and H(2)O(2). exist. keywords: abstraction; acid; activation; activity; addition; amino; antioxidants; atom; attack; base; biological; biology; body; cancer; carbonyl; cardiovascular; cause; cells; chemical; chemistry; chromatography; compounds; contribute; copper; damage; defenses; dependent; development; disease; dna; dna damage; effect; electron; endothelium; enzymes; example; extensive; food; formation; free; free radical; gas; generation; glutathione; h(2)o(2; health; hete; hocl; human; hydrogen; hydroxyl; important; incidence; injury; iron; isoprostanes; levels; lipid; low; mass; measurement; mechanism; metal; molecules; neutrophils; new; nitric; ohdg; onoo; organisms; oxidative; oxidative damage; oxidative dna; oxide; oxygen; ozone; peroxidation; peroxynitrite; plasma; present; products; proteins; radiation; radical; reactions; reactive; repair; residues; role; ros; scheme; sod; solution; species; spectrometry; stress; study; superoxide; supplementation; system; table; tissue; urine; vitamin; vivo cache: cord-0006470-yqh4exz0.txt plain text: cord-0006470-yqh4exz0.txt item: #38 of 251 id: cord-0006665-of0x1h34 author: Ghezzi, Pietro title: Tumor necrosis factor as a pharmacological target date: 2005 words: 2598 flesch: 27 summary: Tumor necrosis factor (TNF) was cloned in 1985. TNF is the main lethal mediator of sepsis. Clinical trials with anti-TNF have not been successful so far, but studies led to the identification of TNF as a key inflammatory mediator and development of anti- TNF molecules for rheumatoid arthritis and Crohn's disease. keywords: action; alpha; anti; antibodies; arthritis; cachectin; clinical; crohn; cytokines; disease; drugs; effect; endotoxin; factor; glucocorticoid; human; inflammation; inflammatory; inhibition; inhibitors; key; mediator; models; molecules; necrosis; patients; production; prostaglandin; receptor; rheumatoid; role; sepsis; septic; shock; soluble; studies; synthesis; tnf; toxicity; trials; tumor; vivo cache: cord-0006665-of0x1h34.txt plain text: cord-0006665-of0x1h34.txt item: #39 of 251 id: cord-0006675-2dah82sw author: Gause, A. title: Der Einsatz von TNFα-Antagonisten bei primär systemischen Vaskulitiden date: 2003 words: 2789 flesch: 31 summary: TNFa blocking drugs Etanercept and Infliximab are effective in the treatment of rheumatoid arthritis. They have also been used successfully in many patients with primary systemic vasculitides. TNFa is involved in the inflammation of small and large vessels. keywords: alle; allerdings; als; ansprechen; antagonisten; anwendung; arthritis; auch; auf; behandelt; behandlung; behçet; bei; bereits; bis; case; churg; cyclophosphamid; das; dass; dem; der; des; die; diese; disease; durch; einer; eingesetzt; einsatz; entzündung; erfahrungen; erfolgreich; erkrankung; etanercept; fällen; für; good; granulomatosis; inflammation; infliximab; infliximabinfusionen; ist; kann; komplikationen; manifestationen; mit; nach; nicht; oder; open; panuveitis; patienten; patients; polyangiitis; polymyalgia; primary; primär; reports; response; rheumatica; rheumatoid; rolle; severe; sich; sind; standardtherapie; strauss; studien; successful; summary; syndrom; systemic; systemischen; takayasu; temporal; therapie; therapy; tnfa; tnfα; treatment; und; unter; use; vasculitis; vaskulitiden; von; vor; waren; wegener; weitere; werden; wiedergegeben; wird; wochen; wurde; zum; zur; zwei; über; übersicht cache: cord-0006675-2dah82sw.txt plain text: cord-0006675-2dah82sw.txt item: #40 of 251 id: cord-0006691-f7y2o5tf author: Calder, Philip C. title: n−3 Polyunsaturated fatty acids and inflammation: From molecular biology to the clinic date: 2003 words: 6988 flesch: 34 summary: The immune system is involved in host defense against infectious agents, tumor cells, and environmental insults. Inflammation is an important component of the early immunologic response. Inappropriate or dysfunctional immune responses underlie acute and chronic inflammatory diseases. Fish oil feeding has been shown to ameliorate the symptoms of some animal models of autoimmune disease and to protect against the effects of endotoxin. Clinical studies have reported that oral fish oil supplementation has beneficial effects in rheumatoid arthritis and among some asthmatics. keywords: acids; activation; acute; adhesion; anti; arthritis; asthma; atopic; cells; chain; chronic; clinical; composition; control; cox-2; cytokine; decreased; dha; dietary; disease; effects; eicosanoids; endothelial; enteral; enzymes; epa; example; expression; factor; fatty; feeding; fig; fish; fish oil; generation; genes; group; human; il-1β; il-6; il-8; immune; important; inflammation; inflammatory; iκb; levels; lower; lox; lps; macrophages; mediators; membrane; mice; molecules; monocytes; murine; n-3; n-3 pufa; nfκb; nuclear; number; nutrition; oil; patients; peroxisome; pge; phospholipids; polyunsaturated; ppar; production; proliferator; pufa; receptor; ref; response; rheumatoid; role; series; studies; study; substrate; surface; tnf; transcription; vcam-1 cache: cord-0006691-f7y2o5tf.txt plain text: cord-0006691-f7y2o5tf.txt item: #41 of 251 id: cord-0006731-gf3idl98 author: Kwong, Yok-Lam title: T-cell large granular lymphocyte leukemia: an Asian perspective date: 2010 words: 3330 flesch: 43 summary: To characterize T-cell large granular lymphocyte leukemia in Asia, 22 Chinese patients from a single institute were reported and analysis of 88 Asian and 272 Western patients identified from the literature was carried out. Asian patients had more frequent anemia, a higher incidence of PRCA, neutropenia, splenomegaly, rheumatoid arthritis, and recurrent infections than Western patients. keywords: analysis; anemia; aplasia; arthritis; articles; asian; cases; cd3; cell; chinese; chronic; clinical; clonal; complete; cyclophosphamide; cyclosporine; differences; different; disease; features; fludarabine; frequency; granular; high; infections; large; leukemia; lgl; literature; lymphocyte; lymphocytosis; neutropenia; patients; prca; pure; red; remission; rheumatoid; single; study; syndrome; tcr; therapy; treatment; western cache: cord-0006731-gf3idl98.txt plain text: cord-0006731-gf3idl98.txt item: #42 of 251 id: cord-0006833-1t031aoy author: Heller, Axel title: Lipid Mediators in Inflammatory Disorders date: 2012 words: 3578 flesch: 28 summary: Inflammatory diseases like rheumatoid arthritis, ulcerative colitis, psoriasis, septic organ failure and sepsis remain the great challenge in intensive care medicine. Many factors contribute to the complex course of inflammatory reactions. Various strategies have been developed to control the excessive production of lipid mediators on different levels of biochemical pathways. Some of these agents exert protective effects in different inflammatory disorders, whereas others fail to. keywords: acid; activity; acute; agents; animal; antagonist; anti; arthritis; asthma; cellular; chemotactic; clinical; cox; cox-2; different; diseases; disorders; effects; enzyme; epa; factor; fatty; fig; human; inflammation; inflammatory; inhibition; inhibitors; leukotriene; levels; lipid; lipoxygenase; ltb; lts; lung; mediators; metabolism; models; paf; patients; permeability; pgi; phospholipase; pla; platelet; properties; receptor; release; rheumatoid; role; sepsis; septic; shock; studies; synthesis; therapeutic; therapy; thromboxane; treatment; txa; ω-3 cache: cord-0006833-1t031aoy.txt plain text: cord-0006833-1t031aoy.txt item: #43 of 251 id: cord-0006875-hfm80xoq author: Banerjee, Shubhasree title: JAK–STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects date: 2017 words: 12848 flesch: 33 summary: The JAK–STAT signaling pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases including rheumatoid arthritis, psoriasis, and inflammatory bowel disease. Tofacitinib, the first rheumetallic Jakinib is approved for arthritis and is currently under investigation for other autoimmune diseases. The development over the past decade and a half of agents targeting cytokines represents a landmark advancement in the treatment of autoimmune and inflammatory diseases. keywords: acr; activation; active; activity; administration; adverse; alopecia; anti; arthritis; associated; autoimmune; baricitinib; bid; binding; blind; blockade; cancer; cause; cell; chronic; clinical; combination; cp-690,550; critical; cyp3a4; cytokines; daily; das28; data; decernotinib; development; different; disease; domain; dose; double; downstream; drug; effective; effects; efficacy; extension; factors; fda; filgotinib; function; generation; growth; healthy; high; human; ifn; iib; iii; il-6; impact; important; improvement; inadequate; increased; infections; inflammatory; inhibitor; interactions; intracellular; jak; jak1; jak2; jak3; jakinibs; jaks; janus; jh1; joint; kinase; levels; like; long; lupus; metabolism; methotrexate; moderate; monotherapy; months; multiple; mutations; non; novel; number; observed; oral; outcomes; pathogenesis; pathway; patients; peficitinib; pharmacokinetics; phase; phase ii; phosphorylation; placebo; plaque; polymorphisms; potential; preliminary; profile; promising; psoriasis; psoriatic; randomized; receptor; response; results; rheumatoid; rheumatoid arthritis; rheumatologic; risk; role; ruxolitinib; safety; selective; selectivity; severe; sh2; signaling; signals; significant; similar; small; specific; stat; stat5b; structure; studies; study; subjects; syndrome; systemic; target; term; therapeutic; therapy; tofacitinib; topical; transcription; treatment; trial; tyk2; type; tyrosine; viral; week cache: cord-0006875-hfm80xoq.txt plain text: cord-0006875-hfm80xoq.txt item: #44 of 251 id: cord-0009011-b05qpb7d author: Riemann, Dagmar title: Demonstration of CD13/Aminopeptidase N on Synovial Fluid T Cells from Patients with Different Forms of Joint Effusions date: 2011 words: 3718 flesch: 43 summary: Riemann, Dagmar, Schwachula, Annette, Hentschel, Michael, Langner, Jürgen and their colleagues studied the immunophenotype of lymphocytes of the synovial fluid (SF) and the peripheral blood (PB) from patients with arthritis. They found a difference in expression of the surface protease aminopeptidase N (AP N/CD13). keywords: activation; addition; aminopeptidase; antibodies; antibody; antigen; arthritis; blood; cd13; cd25; cd26; cd3; cells; conjugated; different; effusions; experiments; expression; fluid; free; healthy; hla; human; incubation; inflammatory; joint; lca; leu; lymphocytes; membrane; mnc; monoclonal; myeloid; non; patients; presence; rheumatoid; specific; staining; surface; synovial; t cells; tissue cache: cord-0009011-b05qpb7d.txt plain text: cord-0009011-b05qpb7d.txt item: #45 of 251 id: cord-0009744-90kt3406 author: Schumacher, H. Ralph title: Synovial pathologic changes in spontaneous canine rheumatoid‐like arthritis date: 2005 words: 3369 flesch: 38 summary: A spontaneous, chronic, erosive polyarthritis similar to human rheumatoid arthritis occurs in dogs. Canine RA-like arthritis affected both pure and mixed breeds. The synovial fluid and membrane were studied in 10 dogs with canine arthritis that fulfilled the American Rheumatism Association (ARA) criteria for classic RA. keywords: affected; arrays; arthritis; canine; cells; changes; criteria; crystalline; dense; deposits; disease; dogs; early; electron; endoplasmic; erythematosus; fibrin; figure; findings; fluid; gross; human; infection; infiltration; joints; large; light; like; lining; lupus; lymphocytes; membrane; microscopic; mononuclear; particles; patients; plasma; pmn; present; reticulum; rheumatoid; similar; structures; studies; study; synovial; synovium; systemic; table; tissue; trs; tubular; tubules; tubuloreticular; virus cache: cord-0009744-90kt3406.txt plain text: cord-0009744-90kt3406.txt item: #46 of 251 id: cord-0009885-r2sz2dm9 author: Holmdahl, Rikard title: Homologous collagen‐induced arthritis in ratg and mice are associated with structurally different major histocompatibility complex DQ‐like molecules date: 2005 words: 2776 flesch: 44 summary: Collagen-induced arthritis (CIA) in rats, induced with homologous type II collagen (CII), has better resemblance to rheumatoid arthritis (RA) than CIA induced with heterologous CII. The DA strain is highly susceptible to CIA, while the Lewis strain is resistant. The only model for RA in which susceptibility to arthritis has reproducibly been shown to be MHC associated is CIA. keywords: abs; anti; arthritis; association; autoantibody; autoimmune; cells; chain; chronic; cia; cii; class; development; different; disease; genes; h-2; haplotypes; heterologous; homologous; homologous cii; immunization; lewis; mhc; mice; molecule; mouse; non; rat; rats; response; responsiveness; rt1; species; strains; structural; susceptibility; susceptible cache: cord-0009885-r2sz2dm9.txt plain text: cord-0009885-r2sz2dm9.txt item: #47 of 251 id: cord-0009982-or5nzvw3 author: Davies, Janet M title: Molecular mimicry: Can epitope mimicry induce autoimmune disease? date: 1997 words: 10049 flesch: 34 summary: Epitope mimicry is the mechanism for the induction of autoimmune disease. It is a form of mimicry used by pathogens to gain entry to target cells, manipulate inter-and intra-cellular processes and avoid immune responses that limit their life cycle in the host. keywords: ability; able; acid; agent; amino; analogues; antibodies; antibody; antigen; antigenie; arthritis; associated; association; autoantibodies; autoimmune; autoimmune disease; autoimmune response; autoimmunity; b cell; bacterial; basic; binding; cardiac; case; cell; cell epitope; cell response; chain; class; complex; coxsackie; cross; crossreactive; data; decarboxylase; dependent; diabetes; disease; dna; dr4; ebv; encephalomyelitis; epitope; epitope mimicry; evidence; experimental; expression; factors; foreign; gad; gbs; heat; high; histoeompatibility; hiv; hla; host; hsp; human; iddm; immunization; immunological; induction; infected; infection; jejuni; kda; mab; major; mbp; mechanism; mhc; mhc class; mice; mimicking; mimicry; mimics; model; molecular; molecular mimicry; molecules; monoclonal; multiple; murine; myelin; myocarditis; myosin; natural; non; normal; ofa; ofthe; parasite; particular; pathogenesis; pathology; patients; peptide; peripheral; present; presentation; primary; proliferation; protein; reactive; reactivity; receptor; recognition; region; residues; response; result; rheumatoid; role; self; sequence; sequence similarity; sera; shock; similarity; sle; snrnp; specific; studies; study; support; surface; syndrome; t cell; target; tcr; theory; tissue; tolerance; type; viral; virus cache: cord-0009982-or5nzvw3.txt plain text: cord-0009982-or5nzvw3.txt item: #48 of 251 id: cord-0011129-z1f2d19o author: Anderson, Martha title: Neonatal Organ and Tissue Donation for Research: Options Following Death by Natural Causes date: 2020 words: 5534 flesch: 42 summary: The donation of organs and tissues from neonates for transplantation is infrequent. Neonatal donation is proving valuable for research into diabetes, pulmonary, gastrointestinal, genitourinary and neurological development, rheumatoid arthritis, autism, childhood psychiatric and neurologic disorders, treatment of MRSA infection and pediatric emergency resuscitation. Since 2010, annual totals of neonatal organ donors in the United States have ranged from 3 to 21 donors annually. keywords: acceptable; act; anencephalic; birth; brain; care; cases; cell; clinical; days; death; delivery; development; diagnosis; donation; donors; early; et al; ethical; families; family; federal; fetal; fig; futile; gift; gray; guidelines; hie; hospital; human; iiam; key; labor; laws; legal; life; lung; maternal; medical; medicine; members; neonatal; neonatal organs; neonate; non; opo; opos; organ; organ donation; parents; pediatric; policies; possible; potential; pre; pregnancy; primary; process; procurement; professionals; protocols; recovery; referrals; regulations; research; researchers; staff; states; term; time; tissues; transplantation; treatment; u.s.c; weeks; writing cache: cord-0011129-z1f2d19o.txt plain text: cord-0011129-z1f2d19o.txt item: #49 of 251 id: cord-0011587-tgmh0mn7 author: Schmalz, Gerhard title: Oral-Health-Related Quality of Life in Adult Patients with Rheumatic Diseases—A Systematic Review date: 2020 words: 4560 flesch: 35 summary: The aim of this systematic review was to assess the oral-health-related quality of life (OHRQoL) of adult patients with rheumatic diseases. Results: 26 out of 41 clinical studies including rheumatoid arthritis (RA), systemic sclerosis (SSc), Sjögren syndrome (SS), Behcet disease (BD), systemic lupus erythematosus (SLE), and ankylosing spondylitis (AS). In 15 studies, a healthy control group was recruited. The short form of the Oral Health Impact Profile (OHIP 14) was most frequently applied. Most studies found the subscale physical disability to be predominantly affected in patients with Rhe keywords: arthritis; available; care; clinical; control; criteria; different; disease; general; group; health; impact; individuals; investigations; life; majority; manifestations; ohip; ohrqol; oral; oral health; parameters; patients; physical; psychosocial; quality; related; relationship; relevance; results; review; rheumatic; rheumatic diseases; sclerosis; search; sjögren; specific; studies; study; subscales; syndrome; systemic; table; tooth; xerostomia cache: cord-0011587-tgmh0mn7.txt plain text: cord-0011587-tgmh0mn7.txt item: #50 of 251 id: cord-0012036-smfpzdpe author: Kanai, Tomotake title: The JNK pathway represents a novel target in the treatment of rheumatoid arthritis through the suppression of MMP-3 date: 2020 words: 4714 flesch: 50 summary: The JNK pathway represents a novel target in the treatment of rheumatoid arthritis through the suppression of MMP-3. NAC suppresses and eliminates ROS, promotes the production of matrix metalloproteinases (MMPs), and suppresses ROS. SP600125 (30 μM) was administered to RA-FLS to suppress MMP 3. keywords: .0001; administering; administration; antioxidant; arthritis; cells; concentration; cultured; decrease; dependent; destruction; dose; effect; expression; factor; fig; fls; human; il-6; induced; inflammatory; inhibitor; japan; jnk; joint; like; low; medium; mh7a; mh7a cells; mmp-3; nac; niigata; nrf2; oxidative; p62; pathway; patients; phosphorylation; primary; production; protein; rheumatoid; ros; solution; sp600125; stress; suppression; synovial; synoviocytes; treatment; untreated; usa; value cache: cord-0012036-smfpzdpe.txt plain text: cord-0012036-smfpzdpe.txt item: #51 of 251 id: cord-0012315-51qadwec author: Cavalli, Marco title: Allele-specific transcription factor binding to common and rare variants associated with disease and gene expression date: 2016 words: 6983 flesch: 46 summary: There are more than 15,000 single nucleotide polymorphisms (SNPs) and insertion/deletions associated with diseases and other phenotypes as summarized in the NIH GWAS catalog. To identify candidate regulatory SNPs, Marco, Pan, Gang, Nord, Helena, Wallerman, Ola, Wallén Arzt, Emelie, Berggren, Olof, Elvers, Ingegerd, Rönnblom, Lars, Lindblad Toh, Kerstin, Wadelius, Claes sequenced ENCODE cell lines and used public ChIP-seq data to look for transcription factors binding preferentially to one allele. The majority of allele-specific variants ( keywords: allele; analysis; association; available; binding; candidate; catalog; cell; chip; chromatin; coding; collection; common; data; difference; disease; dna; ebf1; effect; elements; encode; et al; expression; factor; fig; functional; gene; genetic; genome; gm12878; gwas; haplotype; hesc; heterozygous; high; human; k562; large; lines; loci; material; number; people; population; project; psoriasis; rare; reads; reference; regions; regulatory; rheumatoid; risk; rs909685; rs9603612; seq; sequencing; signals; significant; snps; specific; studies; study; supplementary; table; tfs; transcription; type; variants; variation cache: cord-0012315-51qadwec.txt plain text: cord-0012315-51qadwec.txt item: #52 of 251 id: cord-0012833-5xr3mmvr author: Liao, Xiao-ying title: Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1/3 and MRP2 date: 2019 words: 4988 flesch: 46 summary: Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1/3 and MRP2. It also increased its kidney/plasma ratio and increased its renal injury risk. It is the first synthetic nucleoside analog for the treatment of herpetic virus. keywords: accumulation; acyclovir; administration; associated; cells; clearance; concentration; disposition; drug; effect; efflux; excretion; exposure; fig; fold; group; hbss; hek293; hoat1; inhibited; inhibition; inhibitory; injury; kidney; lef; leflunomide; liver; mdck; metabolite; mk571; mrp2; multidrug; nephrotoxicity; oat1/3; oat3; patients; plasma; plasma concentration; probenecid; protein; renal; resistance; risk; role; studies; study; substrate; ter; time; tissue; transporters; uptake; urinary; urine; value; μmol cache: cord-0012833-5xr3mmvr.txt plain text: cord-0012833-5xr3mmvr.txt item: #53 of 251 id: cord-0012950-p3mb7r0v author: Luo, Yan title: Predicting the treatment response of certolizumab for individual adult patients with rheumatoid arthritis: protocol for an individual participant data meta-analysis date: 2020 words: 5251 flesch: 41 summary: The aim of the study is to develop a model in the treatment of rheumatoid arthritis (RA) patients who receive certolizumab (CTZ) plus methotrexate (MTX) therapy. The primary outcome is efficacy. Secondary outcomes include ACR50 (50% improvement based on ACR core set variables) and adverse events. The model may help clinicians individualize treatment for particular patients. keywords: activity; analysis; approach; arthritis; baseline; bias; certolizumab; characteristics; clinical; control; criteria; ctz; data; developing; disease; effect; estimate; factors; group; individual; information; intervention; ipd; meta; methods; model; months; mtx; outcome; participant; particular; patients; prediction; primary; probability; prognostic; randomized; rcts; regression; relative; remission; reported; reporting; response; review; rheumatoid; rheumatoid arthritis; risk; risk model; score; short; stage; studies; study; systematic; term; treatment; trials; use; validation; variables cache: cord-0012950-p3mb7r0v.txt plain text: cord-0012950-p3mb7r0v.txt item: #54 of 251 id: cord-0015089-wjctpqu8 author: Ledón-LLanes, Loraine title: Views of Mexican outpatients with rheumatoid arthritis on sexual and reproductive health: A cross-sectional study date: 2021 words: 8870 flesch: 38 summary: Rheumatoid arthritis (RA) impacts sexual and reproductive health (SRH) in Mexican patients with RA. The study surveyed 303 Mexican outpatients with RA on SRH importance, SRH satisfaction, access to SRH information, preferences regarding SRH communication with healthcare professionals, and understanding of SRH. keywords: access; activity; addition; age; analysis; approach; arthritis; aspects; assessors; associated; association; borderline; care; categories; changes; characteristics; chronic; clinic; committee; communication; concerns; construct; content; criteria; cross; cultural; descriptions; differences; dimension; disease; distribution; dysfunction; education; expert; factors; family; female; female patients; formal; function; functioning; general; health; healthcare; impact; important; individual; information; issues; item; knowledge; latin; level; life; limited; linear; literacy; major; major themes; mental; mexican; organs; outpatients; overall; para; patients; perspective; physical; physician; planning; population; pregnancy; prevention; professionals; psychological; qualitative; questions; reproductive; reproductive health; research; response; results; rheumatoid; rheumatoid arthritis; rheumatologist; satisfaction; scale; sectional; sexual; sexual health; sexuality; social; srh; srh knowledge; state; studies; study; survey; system; table; themes; topic; use; women; years cache: cord-0015089-wjctpqu8.txt plain text: cord-0015089-wjctpqu8.txt item: #55 of 251 id: cord-0015130-hij65gru author: Mosor, Erika title: Young people’s perspectives on patient-reported outcome measures in inflammatory arthritis: results of a multicentre European qualitative study from a EULAR task force date: 2021 words: 4624 flesch: 43 summary: Patient-reported outcome measures (PROMs) are increasingly used in clinical practice and research. This is the first study that explores perspectives and views of young people with inflammatory arthritis (IA) on widely used PROMs. They did not feel sufficiently informed about the value of PROs and the reasons for collecting them. keywords: activities; activity; areas; arthritis; assessment; chronic; clinical; concepts; countries; daily; data; development; different; disease; european; example; focus; functional; groups; health; healthcare; higher; hps; impact; important; inflammatory; information; issues; items; level; life; local; measurement; measures; new; outcomes; participants; patient; people; personal; perspective; practice; proms; qualitative; quality; reasons; related; relevant; research; results; review; rheumatoid; spa; study; use; work; young; young people cache: cord-0015130-hij65gru.txt plain text: cord-0015130-hij65gru.txt item: #56 of 251 id: cord-0015761-00s5jfs1 author: Hsu, Hui-Ching title: Pneumocystis jirovecii pneumonia in autoimmune rheumatic diseases: a nationwide population-based study date: 2021 words: 3572 flesch: 37 summary: Pneumocystis jirovecii pneumonia (PJP) is an opportunistic organism that can cause high mortality among immunosuppressed patients. PJP risk significantly increased in patients with any ARD and with each individual ARD like rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjogren’s syndrome (SjS), polymyositis and dermatomyositis (PM/DM), systemic sclerosis (SSc), and systemic vasculitis. Mycophenolate seems to be a more prominent risk factor than cyclophosphamide. keywords: age; agents; analysis; ard; biologics; classification; clinical; comorbidities; cox; criteria; cyclophosphamide; data; different; disease; dose; factors; hazard; higher; highest; hiv; incidence; infection; jirovecii; model; mycophenolate; patients; pjp; pjp infection; pneumocystis; pneumonia; prophylaxis; related; risk; sex; sheng; sjs; sle; ssc; steroid; study; systemic; underlying; use cache: cord-0015761-00s5jfs1.txt plain text: cord-0015761-00s5jfs1.txt item: #57 of 251 id: cord-0015995-eb2plovv author: Keyßer, Gernot title: Sicherheitsaspekte der Therapie mit Glukokortikoiden bei rheumatoider Arthritis date: 2021 words: 2154 flesch: 28 summary: Glucocorticoids (GC) are still the recommended initial treatment for rheumatoid arthritis. Long-term treatment exceeding 5 mg prednisolone per day can promote osteoporosis, diabetes, hyperglycemia, cardiovascular events and infections. keywords: adverse; allerdings; als; arthritis; auch; auf; behandlung; bei; cardiovascular; daher; das; dass; data; den; der; diabetes; die; diese; disease; dosage; doses; dosisbereich; effects; effekte; einer; ereignisse; erhöhen; eular; events; faktoren; future; für; glucocorticoid; high; index; infections; infektionen; influence; ist; kardiovaskuläre; klinischen; long; low; mit; mortality; nebenwirkungen; negative; nicht; oder; ohne; oral; osteoporosis; patienten; patients; prednisolon; rheumatoid; risiko; risk; sich; sind; steroid; studien; study; tag; term; therapie; therapy; toxicity; treatment; und; unter; von; war; werden; wurde; zwischen; über cache: cord-0015995-eb2plovv.txt plain text: cord-0015995-eb2plovv.txt item: #58 of 251 id: cord-0016212-111rdyo2 author: Schmidlin, Patrick R. title: Interleukin-35 pathobiology in periodontal disease: a systematic scoping review date: 2021 words: 4452 flesch: 33 summary: Interleukin-35 (IL-35) is an anti-inflammatory cytokine that mediates immunological functions and plays a protective role in several diseases such as asthma and rheumatoid arthritis. The role of IL-35 in gingivitis and periodontitis remains unclear. The aim of the study was to systematically review the literature and collect the available evidence regarding the role of Il-35. The results of the review were published in the journal BMC Oral Health. keywords: alveolar; animal; anti; arthritis; articles; authors; available; bone; cells; chronic; clinical; control; cytokines; data; diabetes; disease; effect; evidence; experimental; expression; function; gcf; gingival; group; healthy; higher; human; il-35; immune; inflammation; inflammatory; interleukin-35; levels; literature; mice; non; pathogenesis; patients; periodontal; periodontal disease; periodontitis; production; rankl; regard; regulatory; relevant; research; resorption; results; review; role; samples; search; serum; studies; study; th17; tissues; treatment; treg; trials; type cache: cord-0016212-111rdyo2.txt plain text: cord-0016212-111rdyo2.txt item: #59 of 251 id: cord-0016426-2nsdlm0i author: Zaatout, Nawel title: Presence of non-oral bacteria in the oral cavity date: 2021 words: 5267 flesch: 17 summary: Zaatout, Nawel and their colleagues review the current knowledge about the presence of non-oral bacteria in the oral cavity and their relationship with oral bacteria. They discuss their association with oral diseases such as periodontitis, caries, gingivitis, and systemic diseases of importance in clinical medicine such as cystic fibrosis, HIV and rheumatoid arthritis. keywords: ability; acinetobacter; activity; aeruginosa; aggressive; antimicrobial; association; aureus; bacteria; baumannii; biofilm; boghossian; canals; cavity; cell; chronic; clear; clinical; colombo; colonizers; complex; dental; different; disease; ecosystem; endodontic; enteric; enterococcus; environment; et al; factors; faecalis; formation; fusobacterium; gnrs; gram; healthy; higher; hiv; host; human; infections; interactions; isolates; microbiota; microorganisms; mutans; negative; non; nucleatum; oral; oral cavity; pathogens; patients; periodontal; periodontitis; positive; presence; prevalence; pseudomonas; pylori; relationship; reservoir; resistance; rods; role; root; saliva; silva; species; staphylococcus; streptococcus; studies; subgingival; subjects; systemic; table; virulence cache: cord-0016426-2nsdlm0i.txt plain text: cord-0016426-2nsdlm0i.txt item: #60 of 251 id: cord-0016447-bda4e3fo author: Takeuchi, Tsutomu title: Safety and Effectiveness of Peficitinib (ASP015K) in Patients with Rheumatoid Arthritis: Final Results (32 Months of Mean Peficitinib Treatment) From a Long-Term, Open-Label Extension Study in Japan, Korea, and Taiwan date: 2021 words: 5309 flesch: 48 summary: Peficitinib (ASP015K) is a pan-Janus kinase inhibitor used to treat rheumatoid arthritis in Japan, Korea, and Taiwan. 843 patients received it for a mean 32.0 months (maximum 85.2 months) and most (64.4%) received 100 mg/day as a maximum dose. keywords: adverse; analysis; arthritis; asian; baseline; clinical; co.; crp; das28; data; day; disease; dose; drug; effectiveness; efficacy; events; extension; fig; final; herpes; incidence; interim; jak; japan; long; ltd; lte; mean; months; overall; patients; peficitinib; pharma; phase; raj1; raj3; raj4; rates; response; results; rheumatoid; safety; studies; study; supplementary; teaes; term; treatment; week; zoster cache: cord-0016447-bda4e3fo.txt plain text: cord-0016447-bda4e3fo.txt item: #61 of 251 id: cord-0016676-1c94qcm0 author: Wang, Ziyu title: Salubrinal Alleviates Collagen-Induced Arthritis through Promoting P65 Degradation in Osteoclastogenesis date: 2021 words: 4864 flesch: 34 summary: Salubrinal is a small molecule compound that has been shown to exert beneficial effects on bone tissue. It is effective in reducing collagen-induced arthritis in DBA/1J mice. It also inhibits RANKL-induced NF-κB signaling pathway and promotes P65 degradation through the ubiquitin-proteasome system. keywords: abundance; arthritis; bone; cells; cia; clinical; collagen; csf; ctsk; damage; data; days; degradation; dependent; destruction; differentiation; effects; expression; factor; figure; formation; function; inhibited; inhibitor; joint; knockdown; levels; marrow; mice; nfatc1; number; osteoclast; osteoclastogenesis; p65; pathway; potential; precursors; proteasome; protein; rankl; resorption; results; salubrinal; salubrinal treatment; signaling; staining; study; system; trap; treatment; ubiquitin; usa cache: cord-0016676-1c94qcm0.txt plain text: cord-0016676-1c94qcm0.txt item: #62 of 251 id: cord-0016741-ehvc43de author: Deng, Zhengyu title: Inflammation-responsive delivery systems for the treatment of chronic inflammatory diseases date: 2021 words: 10154 flesch: 15 summary: Inflammation is the biological response of immune system to protect living organisms from injurious factors. Excessive and uncontrolled inflammation is implicated in a variety of chronic diseases, including atherosclerosis, inflammatory bowel disease (IBD), cystic fibrosis (CF), rheumatoid arthritis (RA), Alzheimer's disease (AD), and so on. Inflammation-specific drug delivery systems (DDSs) hold significant promise for the treatment of chronic inflammatory diseases. keywords: accumulation; acid; acidic; activities; activity; acute; administration; agents; alzheimer; amyloid; anti; antiinflammatory; antioxidant; applications; arthritis; atherosclerosis; authors; bilirubin; bioactive; biocompatible; biodegradable; biological; biosynthesis; brain; capable; cells; chronic; chronic inflammatory; cleavable; clinical; coauthors; colitis; conjugate; copyright; coworkers; curcumin; cytokines; ddss; degradation; delivery; design; development; dex; dextran; diseases; drug; drug delivery; dspe; dual; effects; efficacy; efficient; enhanced; enzyme; ester; exo; expression; fig; free; gelatin; group; heme; high; human; hydrogel; hydrophobic; imaging; immune; inflamed; inflammation; inflammatory; inflammatory diseases; inhibit; injection; instance; interactions; joint; lesions; levels; linkage; low; macrophages; management; metal; micelles; microenvironment; microglia; microparticles; microspheres; milieu; model; nanocarriers; nanomedicine; nanoparticles; neutrophil; novel; overexpressed; oxalate; oxidation; oxidative; oxide; oxygen; pathological; peg; permission; phenylboronic; plaques; platform; plga; polyketal; polymeric; polymersomes; potential; pps; process; products; promising; proteins; reactive; reduction; reductive; ref; release; responsive; responsive nanoparticles; responsiveness; rheumatoid; ros; scavenging; selective; self; sensitive; sirna; sites; species; specific; stimuli; stress; superior; supramolecular; systems; targeted; targeting; theranostic; therapeutic; therapy; tissues; tkns; tnf; treatment; vivo cache: cord-0016741-ehvc43de.txt plain text: cord-0016741-ehvc43de.txt item: #63 of 251 id: cord-0016807-apofatya author: Wang, Juan title: Effects of illness perceptions on health-related quality of life in patients with rheumatoid arthritis in China date: 2021 words: 4271 flesch: 43 summary: For 191 patients with rheumatoid arthritis in China, their illness perceptions affect their health-related quality of life (HRQoL). Illness perceptions were measured using the Brief Illness Perceptions Questionnaire (BIPQ) comprising 8 domains. The overall BIPQ of patients with RA was 49.09 ± 11.06. The highest and lowest scores were for concern (9.15 ± 1.81) and personal control (4.30 ± 2.52). keywords: activity; analysis; anxiety; arthritis; bipq; china; chinese; control; data; depression; dimension; disease; domains; emotional; function; general; health; hrqol; identity; illness; life; limitations; lupus; mental; model; negative; pain; patients; perceptions; personal; physical; present; problems; quality; rheumatoid; role; score; sf-36; social; study; systemic; total; treatment; variables; vitality cache: cord-0016807-apofatya.txt plain text: cord-0016807-apofatya.txt item: #64 of 251 id: cord-0016924-vvzv1gc4 author: Sakkas, Andreas title: Tocilizumab: Another medication related to osteonecrosis of the jaws? A case report and literature review date: 2021 words: 4642 flesch: 27 summary: Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication in patients receiving antiresorptive medication, such as bisphosphonates and denosumab for different oncologic and non-oncologic diseases. A 45-year-old female patient with severe rheumatoid arthritis had been undergoing intravenous tocilizumab therapy for three years. Four weeks after the tooth extractions, she felt pain in both jaws. She underwent surgical debridement of necrotic bone, and intravenous antibiotics were administered in hospital. Five months later, wound dehiscence reoccurred in the same regions. The patient underwent local bone resection and keywords: alveolar; antibiotics; antiresorptive; arthritis; bevacizumab; bisphosphonate; bone; bony; case; clinical; covid-19; debridement; dehiscence; denosumab; department; diagnosis; disease; effects; exposed; extraction; figure; following; history; inflammatory; inhibitors; interleukin-6; intraoral; intravenous; jaw; jaws; left; like; local; mandible; mandibular; maxilla; maxillofacial; medication; methotrexate; months; mronj; necrotic; onset; oral; osteomyelitis; osteonecrosis; pain; pathogenesis; patient; persistent; receptor; region; report; rheumatoid; risk; role; severe; signs; sockets; studies; surgeons; surgery; surgical; symptoms; therapy; tocilizumab; tooth; treatment; use; weeks; wound; year cache: cord-0016924-vvzv1gc4.txt plain text: cord-0016924-vvzv1gc4.txt item: #65 of 251 id: cord-0017076-eenxr5dj author: Solipuram, Vinod title: Effect of janus kinase inhibitors and methotrexate combination on malignancy in patients with rheumatoid arthritis: a systematic review and meta-analysis of randomized controlled trials date: 2021 words: 3888 flesch: 44 summary: Rheumatoid arthritis affects about 0.5% to 1% of the population. The combination therapy of methotrexate (MTX) and Janus kinase inhibitor (JAKi) is commonly used to treat RA. It is not associated with an increased risk of malignancy in patients with RA. keywords: analysis; arthritis; baricitinib; cancer; combination; data; deaths; difference; effect; events; fig; group; incidence; inflammation; jaki; janus; kinase; lymphoma; malignancies; malignancy; meta; methotrexate; mtx; nmsc; non; patients; phase; random; rcts; response; results; review; rheumatoid; risk; sae; safety; significant; studies; study; systematic; therapy; tofacitinib; trials; years cache: cord-0017076-eenxr5dj.txt plain text: cord-0017076-eenxr5dj.txt item: #66 of 251 id: cord-0018506-unh840wg author: Bustami, Mona title: The Prevalence of Overweight and Obesity Among Women in Jordan: A Risk Factor for Developing Chronic Diseases date: 2021 words: 3433 flesch: 47 summary: There is a high prevalence of overweight and obesity among women in Jordan. High BMI increases the risk of a wide range of chronic diseases. High parity was significantly associated with obesity and elementary education. Chronic diseases are expected to accelerate rapidly in Jordan from 2005 to 2050. keywords: age; analysis; arthritis; associated; association; bmi; chronic; data; diabetes; diseases; early; education; factors; hand; health; high; hypertension; hypertriglyceridemia; jordan; jordanian; kids; level; low; obese; obesity; odds; osteoporosis; overweight; parity; participant; percentage; population; prevalence; related; research; rheumatoid; risk; significant; socioeconomic; status; studies; study; table; university; variables; women; years cache: cord-0018506-unh840wg.txt plain text: cord-0018506-unh840wg.txt item: #67 of 251 id: cord-0018645-epplar05 author: Mate, Gitanjali S. title: An Efficient CNN for Hand X-Ray Classification of Rheumatoid Arthritis date: 2021 words: 4984 flesch: 43 summary: Convolutional neural network (CNN) is the center for hand recognition for recognizing complex examples. It has the ability to gain proficiency with the qualities and anticipate the class of hand radiographs from an expansive collection. The result indicates that hand X-rays are rated with an accuracy of 94.46% by the proposed methodology. keywords: accessible; accuracy; activity; appraisal; arrangement; arthritis; assessment; automatic; beam; bone; calculation; capacity; case; channel; classification; classifier; cnn; convolution; convolution layer; dataset; deep; different; disease; essential; evaluation; exactness; figure; framework; hand; human; image; imaging; infection; inflammation; information; issue; joint; layer; learning; level; machine; map; model; movement; network; neural; organization; overfitting; pain; patients; pictures; pixels; pooling; preparation; profound; radiographs; related; rheumatoid; rheumatoid arthritis; significant; space; stage; standard; strategies; strategy; svm; technique; test; time; training; treatment; ultrasound cache: cord-0018645-epplar05.txt plain text: cord-0018645-epplar05.txt item: #68 of 251 id: cord-0019815-7wb3h1iu author: Ishii, Nobuyasu title: A Single-Center Retrospective Observational Study Evaluating the Favorable Predictive Factors for the Disease Control Time of Treatment with Tocilizumab in Patients of Rheumatoid Arthritis date: 2021 words: 3154 flesch: 44 summary: Tocilizumab (TCZ) is a humanized monoclonal antibody against the IL-6 receptor. It is effective in the treatment of rheumatoid arthritis (RA). We conducted a retrospective observational study to determine how long TCZ controls RA. DCT was significantly increased in patients who had never received previous biologic disease-modifying anti-rheumatic drugs treatment. High baseline CRP value was an independent favorable predictive factor for longer DCT. keywords: analysis; anti; antibody; arthritis; baseline; bdmards; blood; clinical; control; crp; dct; disease; efficacy; event; factor; favorable; groups; high; history; il-6; independent; median; medical; months; patients; predictive; previous; protein; receptor; remission; retrospective; rheumatoid; significant; study; table; tcz; time; tocilizumab; treatment; univariate; value cache: cord-0019815-7wb3h1iu.txt plain text: cord-0019815-7wb3h1iu.txt item: #69 of 251 id: cord-0019844-cb6djwx0 author: Yan, Qingran title: Comparison of iguratimod and conventional cyclophosphamide with sequential azathioprine as treatment of active lupus nephritis: study protocol for a multi-center, randomized, controlled clinical trial (iGeLU study) date: 2021 words: 5464 flesch: 45 summary: Iguratimod (IGU) is a new small molecular, anti-rheumatic drug. It has been approved for treating rheumatoid arthritis in northeast Asia. The study is a head-to-head comparison between the iguratimmod and present first-line therapy on Lupus nephritis patients. The primary outcome is renal remission rate. keywords: active; adverse; agents; analysis; anti; arthritis; autoimmune; azathioprine; blood; case; cell; china; clinical; committee; consent; control; criteria; cyclophosphamide; data; disease; dose; drug; effect; efficacy; end; erythematosus; ethics; events; fas; follow; following; form; group; iguratimod; induction; informed; laboratory; lupus; lupus nephritis; major; medical; medication; monotherapy; nephritis; new; oral; participants; patients; potential; protocol; randomized; rate; recent; refractory; related; remission; renal; report; research; rheumatoid; safety; screening; secondary; set; sle; statistical; study; subjects; systemic; table; team; test; therapy; time; treatment; trial; value; visit; weeks cache: cord-0019844-cb6djwx0.txt plain text: cord-0019844-cb6djwx0.txt item: #70 of 251 id: cord-0019975-u1n96ucc author: Wei, Wenyang title: Use of Network Pharmacology to Investigate the Mechanism of the Compound Xuanju Capsule in the Treatment of Rheumatoid Arthritis date: 2021 words: 5191 flesch: 32 summary: Rheumatoid arthritis (RA) is an autoimmune dysfunction disease. Traditional Chinese Medicine has been used to treat RA for more than 3,000 years in China. The active ingredients in Chinese medicine could weaken the activity of RA and protect joints from deformity. keywords: 3.7.1; acid; active; active ingredients; activity; analysis; anti; arthritis; biomed; black; blood; bone; cells; chinese; common; common targets; components; compound xuanju; core; cytokine; cytoscape; database; degree; differentiation; disease; effect; factors; figure; fructus; il-17; il-6; inflammatory; ingredients; interaction; kegg; mechanism; medicine; molecular; multiple; network; network pharmacology; nodes; pathway; pharmacology; potential; ppi; ra pathway; receptor; related; research; response; results; rheumatoid; rheumatoid arthritis; signaling; software; study; synovial; targets; tcm; th17; tnf; toll; traditional; treatment; value; xuanju capsule cache: cord-0019975-u1n96ucc.txt plain text: cord-0019975-u1n96ucc.txt item: #71 of 251 id: cord-0020036-06eoyi7n author: Tong, Xiang title: Exploring the role of monocyte chemoattractant protein-1 in fibroblast-like synovial cells in rheumatoid arthritis date: 2021 words: 5670 flesch: 52 summary: Monocyte chemoattractant protein-1 (MCP-1) promoted FLS proliferation and migration and affected the apoptosis of fibroblast-like synovial cells in rheumatoid arthritis rats. The expression levels of p-P38, p-PI3K, PI3K and CD31 were increased in patients with RA. keywords: ability; activity; addition; analysis; arthritis; cat; cd31; cells; clinical; concentration; crp; cytokines; das28; data; disease; et al; experiments; expression; fibroblast; fig; figs; flss; free; healthy; human; important; increased; individuals; inflammatory; joint; level; like; mcp-1; medium; migration; min; normal; overexpression; p38; patients; pbs; pi3k; plate; present; proliferation; protein; qpcr; rat; rats; results; rheumatoid; role; rpm; samples; serum; significant; silencing; sirna; slides; solution; study; times; tnf; total; transfection; vegf cache: cord-0020036-06eoyi7n.txt plain text: cord-0020036-06eoyi7n.txt item: #72 of 251 id: cord-0020892-q93j84t6 author: Han, Liang title: A comprehensive transcriptomic analysis of alternate interferon signaling pathways in peripheral blood mononuclear cells in rheumatoid arthritis date: 2021 words: 7151 flesch: 46 summary: Rheumatoid arthritis (RA) is an autoimmune inflammatory disease affecting about 0.5-1% of the world population. Interferon (IFN) signaling pathways play crucial roles in the pathogenesis of RA. IFNs are important immunomodulators and play a role in the immune system. keywords: activation; activity; addition; aging; alterations; analysis; arthritis; b cells; blood; bright; cd14; cd16; cd4; cd56; cd8; cells; ch25h; clusters; cytokines; cytotoxic; data; different; differentiation; dim; distinct; effects; enrichment; expression; factors; figure; function; genes; gsea; human; ifn; ifns; immune; inflammatory; interferon; marker; monocytes; multiple; natural; naïve; nk cells; package; pathways; patients; pbmcs; peripheral; plasma; potential; present; previous; production; regulation; regulatory; research; response; results; rheumatoid; role; scenic; scrna; sets; signaling; single; stat1; studies; study; synovial; t cells; transcription; type; upregulated; version cache: cord-0020892-q93j84t6.txt plain text: cord-0020892-q93j84t6.txt item: #73 of 251 id: cord-0021311-hnmpfc10 author: Lv, Xiaolan title: Umbilical Cord Mesenchymal Stem Cell Therapy for Regenerative Treatment of Rheumatoid Arthritis: Opportunities and Challenges date: 2021 words: 5254 flesch: 36 summary: Rheumatoid arthritis (RA) is an autoimmune disease with a high rate of disability. Traditional treatments for RA remain a challenging issue. Regenerative medicine and umbilical cord mesenchymal stem cell therapy (UC-MSC) therapies have recently emerged as potential options. UC-MSCs have advantages, such as convenient collection of materials and no ethical disputes. However, there have been few studies regarding the effects on RA patients. keywords: activity; adalimumab; adverse; agents; anti; application; arthritis; autoimmune; blood; bone; cells; clinical; cord; cord blood; cytokines; damage; development; differentiation; disease; drugs; early; effects; efficacy; expression; factor; generation; group; growth; human; immune; immunomodulatory; induced; inflammation; inflammatory; inhibitors; joint; levels; marrow; medicine; mesenchymal; mesenchymal stem; mhc; model; molecules; mscs; nsaids; patients; potential; progenitor; reactions; recent; regenerative; repair; research; results; review; rheumatoid; rheumatoid arthritis; role; safety; serum; stem; stem cells; stromal; studies; study; symptoms; therapeutic; therapy; tissue; tnf; transplantation; treatment; trial; umbilical; umbilical cord; use; vitro; wound; years cache: cord-0021311-hnmpfc10.txt plain text: cord-0021311-hnmpfc10.txt item: #74 of 251 id: cord-0021655-m7q1m8ow author: Choquette, Denis title: Monitoring the transition of patients on biologics in rheumatoid arthritis: Consensus guidance for pharmacists date: 2021 words: 3478 flesch: 42 summary: Consensus derived monitoring algorithm for pharmacists was created to facilitate best practices throughout therapeutic transitions from originator biologics to other originatorBiologics, biosimilars, and Janus kinase inhibitors in RA. New classes of anti-rheumatic drugs including JAKi and introduction of biosimilar are presenting more opportunity for therapeutic changes and monitoring in patients with RA. keywords: action; arthritis; best; biologic; biosimilars; changes; clinical; consensus; considerations; drugs; effect; efficacy; group; guidance; ideas; important; inflammatory; language; list; monitoring; need; new; ngt; nocebo; nominal; non; originator; outcome; participants; patients; pharmacists; positive; questions; reference; response; results; review; rheumatoid; rheumatologist; safety; technique; therapeutic; therapy; tool; transition; treatment; unmet; use cache: cord-0021655-m7q1m8ow.txt plain text: cord-0021655-m7q1m8ow.txt item: #75 of 251 id: cord-0021971-aneqe5h1 author: Kwon, Eui-Jong title: Impact of Posttranslational Modification in Pathogenesis of Rheumatoid Arthritis: Focusing on Citrullination, Carbamylation, and Acetylation date: 2021 words: 9160 flesch: 25 summary: Rheumatoid arthritis (RA) is the most common form of chronic inflammatory arthritis. It is caused by prolonged periodic interactions between genetic, environmental, and immunologic factors. Posttranslational modifications (PTMs) such as citrullination, carbamylation, and acetylation are correlated with the pathogenesis of RA. Certain microbial infections, such as Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Prevotella copri, can induce autoantigens in RA. Smoking is correlated with both PTMs and AMPAs in the development of RA, but there is no evidence that smoking induces the generation of AMP keywords: acetylation; acpa; activity; affinity; alleles; analysis; anti; antibodies; antibody; apoptosis; arginine; arthritis; articular; associated; association; autoantibodies; autoantigens; autocitrullination; autoimmune; autoimmunity; autophagy; binding; carbamylated; carbamylation; carp; carp antibodies; cell; chronic; citrullination; citrulline; complement; complex; cross; death; deiminase; development; diagnosis; differentiation; disease; drb1; early; enolase; epitopes; exposure; expression; extracellular; factor; fibroblast; fls; formation; gingivalis; h17; helper; higher; hla; human; igg; igm; il-6; immune; independent; inflammation; inflammatory; isotype; joints; levels; like; low; lth; lysine; macrophages; mechanisms; meta; molecules; multiple; necrosis; negative; netosis; neutrophils; onset; osteoclast; pad; pad4; pathogenesis; pathways; patients; peptide; peptidylarginine; periodontitis; pore; porphyromonas; positive; potential; ppad; presence; process; produce; production; protein; protein antibodies; ptms; ra patients; receptor; regulatory; residues; response; rheumatoid; rheumatoid arthritis; risk; role; signaling; smoking; specific; specificity; study; synovial; synoviocytes; t cell; target; terminal; therapy; tnf; treatment; type; vitro cache: cord-0021971-aneqe5h1.txt plain text: cord-0021971-aneqe5h1.txt item: #76 of 251 id: cord-0021984-j1rnm9eo author: Hedar, Ahmed M. title: Autoimmune Rheumatic Diseases and Vascular Function: The Concept of Autoimmune Atherosclerosis date: 2021 words: 8385 flesch: 24 summary: Autoimmune rheumatic diseases with unknown etiology are increasing in incidence and prevalence. Up to 5% of the population is affected. Atherosclerosis is the main underlying cause of cardiovascular diseases in autoimmune diseases. Traditional risk factors like age, age, hypercholesterolemia, smoking, diabetes mellitus, and hypertension do not alone explain the risk of atherosclerosis present in autoimmune rheumatoid diseases. keywords: activity; age; airds; amyloidosis; analysis; antibodies; antibody; arterial; artery; arthritis; arthritis patients; assessment; associated; association; atherosclerosis; autoimmune; autoimmune diseases; autoimmune rheumatic; blood; cardiac; cardiovascular; cardiovascular diseases; cardiovascular risk; carotid; cells; chronic; clinical; common; control; coronary; cytokines; development; diseases; drugs; dysfunction; early; effects; endothelial; erythematosus; factors; failure; flow; fmd; formation; function; heart; helper; high; hypertension; important; increase; infarction; inflammation; inflammatory; intima; ldl; lipoprotein; literature; lupus; lupus erythematosus; major; media; mortality; myocardial; nitric; normal; obesity; oxide; oxidized; patients; plaque; population; premature; presence; pressure; prevalence; primary; process; pss; retinal; review; rheumatic diseases; rheumatoid; rheumatoid arthritis; risk; risk factors; role; secondary; sjögren; sle; state; stiffness; studies; study; subclinical; syndrome; systemic; thickness; traditional; vasculitis; vessels; women; years cache: cord-0021984-j1rnm9eo.txt plain text: cord-0021984-j1rnm9eo.txt item: #77 of 251 id: cord-0022253-6gvn6tzb author: Gebretsadik, Achamyelesh title: Balneotherapy for Musculoskeletal Pain Management of Hot Spring Water in Southern Ethiopia: Perceived Improvements date: 2021 words: 3285 flesch: 52 summary: The study looked at the effect of balneotherapy on musculoskeletal disorder pain and its perceived improvement among users of hot spring water in Southern Ethiopia. It found that hot spring baths for three and more days have significant therapeutic effects on patients with musculo-arthritis and rheumatoid arthritis. keywords: arthritis; balneotherapy; bath; blood; complaints; conditions; data; days; diseases; disorders; duration; effects; ethiopia; health; hot; hot spring; immersion; joint; laboratory; management; medicine; muscle; musculoskeletal; pain; participants; patients; rate; research; rheumatoid; samples; score; site; southern; spring; studies; study; symptoms; table; test; therapeutic; total; treatment; users; water; work cache: cord-0022253-6gvn6tzb.txt plain text: cord-0022253-6gvn6tzb.txt item: #78 of 251 id: cord-0022420-8xnhl3zl author: Guagnano, Maria Teresa title: Improvement of Inflammation and Pain after Three Months’ Exclusion Diet in Rheumatoid Arthritis Patients date: 2021 words: 5558 flesch: 46 summary: In 40 patients with long-standing RA, the effect of a 3-month diet avoiding meat, gluten, and lactose (and all dairy products) was evaluated in comparison with a control balanced diet. Both diets were designed to reduce weight since all patients were overweight or obese. With either diet, patients showed significant decreases in body weight and body mass index, with a reduction in waist and hips circumference and lower basal glucose and circulating leptin levels. A privative diet was also able to significantly reduce systolic and diastolic arterial pressure. keywords: activity; arthritis; assessment; balanced; better; blood; changes; control; das; decrease; deprived; diet; dietary; differences; disease; fat; figure; fish; gluten; group; group b; haq; health; increase; index; inflammatory; intake; items; leptin; levels; life; lower; mass; meat; median; mediterranean; mental; months; obese; pain; patients; physical; pressure; protein; quality; questionnaire; reduction; rheumatoid; rheumatoid arthritis; rho; risk; role; score; sf-36; significant; state; study; table; time; total; values; vas; weight cache: cord-0022420-8xnhl3zl.txt plain text: cord-0022420-8xnhl3zl.txt item: #79 of 251 id: cord-0022896-cfh54kf5 author: Li, Jing title: Effect of family caregiver nursing education on patients with rheumatoid arthritis and its impact factors: A randomized controlled trial date: 2021 words: 4491 flesch: 40 summary: Li, Jing, Zhang, Ying, Kang, Ya-Juan, Ma, Nan and their colleagues conducted a randomized controlled trial on the effect of family caregiver nursing education (FCNE) on rheumatoid arthritis (RA) on patients and their caregivers. They found that FCNE significantly reduced indicators of RA in the intervention group compared to the control group. keywords: activity; adherence; age; anxiety; arthritis; baseline; caregivers; cases; cdai; control; crp; data; depression; disease; disorder; duration; education; effect; elderly; esr; factors; family; fcne; follow; group; health; impact; indicators; inflammation; intervention; intervention group; level; mood; nursing; participants; patients; people; relationship; review; rheumatoid; sdai; self; significant; stroke; study; systematic; time; tnf; training; years cache: cord-0022896-cfh54kf5.txt plain text: cord-0022896-cfh54kf5.txt item: #80 of 251 id: cord-0023087-n4lffmo1 author: Khan, Tanjila title: A Closer Look at the Role of Anti-CCP Antibodies in the Pathogenesis of Rheumatoid Arthritis-Associated Interstitial Lung Disease and Bronchiectasis date: 2021 words: 5377 flesch: 37 summary: Rheumatoid arthritis (RA) is an articular disease with extra-articular manifestations. Pulmonary manifestations include bronchiectasis, bronchiolitis, interstitial lung disease (ILD), pleural effusions and parenchymal lung nodules. Anti-CCP antibodies (ACPAs) play a key role in the pathogenesis of RA lung involvement. ACPA is associated with more severe disease even in the absence of articular symptoms. keywords: acpa; airway; antibodies; antibody; arthritis; article; articular; associated; autoimmune; bronchiectasis; citrullination; clear; clinical; context; control; development; disease; evidence; factor; features; fibrosis; genetic; group; higher; hla; idiopathic; ild; individuals; infection; inflammation; inflammatory; interstitial; involvement; ipaf; ipf; known; levels; lung; lung disease; manifestations; muc5b; pathogenesis; patients; pattern; peptide; pneumonia; positive; presence; prevalence; pulmonary; research; review; rheumatoid; rheumatoid arthritis; risk; role; smoking; studies; study; symptoms; systemic; tissue; titers; treatment; trials; uip; years cache: cord-0023087-n4lffmo1.txt plain text: cord-0023087-n4lffmo1.txt item: #81 of 251 id: cord-0023487-351097vu author: Radu, Andrei-Flavius title: Management of Rheumatoid Arthritis: An Overview date: 2021 words: 14146 flesch: 34 summary: Rheumatoid arthritis (RA) is a multifactorial autoimmune disease of unknown etiology. Good RA management requires a multidisciplinary approach. The most promising results were obtained by developing disease-modifying anti-rheumatic drugs (DMARDs). keywords: abatacept; accurate; acpa; acr; activity; adalimumab; adverse; agents; air; american; analysis; anti; antibodies; antibody; anxiety; approaches; arthritis; arthritis patients; articular; associated; association; autoimmune; baricitinib; bdmards; biomarkers; blind; bone; cancer; cardiovascular; cartilage; case; cells; certain; changes; clinical; cohort; common; comorbidities; complications; control; corresponding; criteria; csdmards; current; cytokines; data; depression; detection; development; diagnosis; differences; different; disease; double; drugs; eams; early; effective; effects; efficacy; erosions; etanercept; eular; events; evidence; exposure; extra; factors; future; general; good; high; higher; imaging; important; incidence; increase; infections; inflammation; inflammatory; infliximab; inhibitors; jaki; janus; joints; kinase; levels; life; like; long; low; lower; lung; management; manifestations; mechanisms; medical; meta; molecules; monotherapy; mri; mtx; new; non; nsaids; numerous; observational; omega-3; order; pain; participants; pathogenesis; patients; pharmacological; phase; placebo; population; positive; potential; prevalence; prevention; processes; profile; prognostic; progression; protein; pufas; pulmonary; ra patients; randomized; rates; recent; receptor; recommendations; related; research; response; results; review; rheumatoid; rheumatoid arthritis; risk; rituximab; role; safety; screening; serum; severe; significant; skin; small; specific; structures; studies; study; symptoms; syndrome; synovial; systematic; targets; term; therapeutic; therapies; therapy; time; tnf; tnfi; tofacitinib; tools; treatment; trials; types; use; years cache: cord-0023487-351097vu.txt plain text: cord-0023487-351097vu.txt item: #82 of 251 id: cord-0024570-ibo1bxxw author: Chen, Conan title: Effects of sub-threshold transcutaneous auricular vagus nerve stimulation on cerebral blood flow date: 2021 words: 4773 flesch: 45 summary: Transcutaneous auricular vagus nerve stimulation (taVNS) has shown promise as a non-invasive alternative to VNS with implantable devices to treat drug-resistant epilepsy and treatment-resistant depression. The aim of this study was to determine whether high-frequency sub-threshold taVNS induces significant changes in cerebral blood flow. Arterial spin labeling (ASL) MRI scans were performed on 20 healthy subjects in a single-blind placebo-controlled repeated measures experimental design. The results showed that 15 minutes of taV NS can induce sustained CBF decreases in the bilateral posterior cerebellum in healthy subjects. keywords: analysis; arterial; asl; auricular; blood; bold; brain; cbf; cerebellar; cerebral; changes; clinical; cluster; contrast; control; current; decreases; depression; ear; effects; evoked; findings; flow; fmri; frequency; functional; future; healthy; high; hoc; increases; labeling; main; measures; min; mri; nerve; nerve stimulation; patients; pet; placebo; post; pre; prior; randomized; regions; response; scans; section; session; sham; significant; single; spin; state; stimulation; stimulus; studies; study; subjects; sustained; tavns; threshold; transcutaneous; treatment; use; vagus; vagus nerve; work cache: cord-0024570-ibo1bxxw.txt plain text: cord-0024570-ibo1bxxw.txt item: #83 of 251 id: cord-0024589-8b6a30a8 author: Aljurbua, Faisal I. title: A cross-sectional study on generalized anxiety disorder and its socio-demographic correlates among the general population in Saudi Arabia date: 2021 words: 2950 flesch: 44 summary: There is a high prevalence of anxiety disorders in the general population in Saudi Arabia. The study was carried out to screen for GAD among adults and determine the correlation of anxiety disorder with other comorbidities. It was approved by the hospital research committee and the Institutional Review Board. keywords: aged; anxiety; arabia; care; chronic; conditions; covid-19; cross; degree; depression; disease; disorder; factors; females; gad; general; health; higher; medical; mental; mild; participants; patients; population; prevalence; psychological; questionnaire; saudi; sectional; severe; severity; significant; students; study; years cache: cord-0024589-8b6a30a8.txt plain text: cord-0024589-8b6a30a8.txt item: #84 of 251 id: cord-0024768-9fyrlsc5 author: Meißner, Yvette title: Neues aus dem RABBIT-Register date: 2021 words: 2486 flesch: 34 summary: Since 2001 rheumatologists in Germany have been recruiting patients with Rheumatoid arthritis into the biologics register to investigate the long-term safety and efficacy of modern antirheumatic treatment. Over the past 20 years more than 20,000 patients have been enrolled in the prospective cohort study. With herpes zoster, facial nerve palsy and psoriasis, several adverse events were investigated. The majority of patients observed in RABBIT were satisfied with the treatment they have received after 1 year. keywords: aber; als; antirheumatic; arthritis; article; auch; auf; aus; behandlung; biologics; biosimilars; clinical; cohort; das; dass; data; daten; dem; den; der; des; die; diese; disease; dmard; drug; durch; early; effectiveness; efficacy; einer; einschluss; ersten; events; factors; für; gibt; global; herpes; infection; infektionen; influence; inhibitors; innen; insbesondere; jahr; jaki; können; long; mit; nach; noch; obesity; oder; outcomes; patient; psoriasis; publikation; rabbit; register; rheumatoid; risiko; risk; safety; sich; sind; sowie; studies; study; term; therapie; tnf; treatment; und; unter; von; werden; wir; wird; wurde; zoster; zufriedenheit; zum; zur cache: cord-0024768-9fyrlsc5.txt plain text: cord-0024768-9fyrlsc5.txt item: #85 of 251 id: cord-0024898-h156n6jj author: Mucke, Johanna title: TELERA—Asynchronous TELEmedicine for Patients With Rheumatoid Arthritis: Study Protocol for a Prospective, Multi-Center, Randomized Controlled Trial date: 2021 words: 4335 flesch: 41 summary: The TELERA study is a prospective, multi-center, randomized controlled trial performed in four German university centers. The main outcome is the agreement of rheumatologists' treatment decisions based on patient-generated data and traditional in-person clinic-based decisions. The study received ethical approval by the Committee of the University Clinic of Tuebingen. keywords: abaton; activation; activity; agreement; analyses; app; arthritis; assessment; asynchronous; care; change; clinical; consent; count; crp; data; days; disease; electronic; epros; examination; face; german; health; index; informed; joint; local; management; monitoring; participants; patient; personnel; physician; questionnaires; quick; randomized; remote; results; rheumatoid; rheumatologists; rheumatology; routine; scale; score; self; semi; study; tele; telemedicine; test; therapeutic; time; treatment; trial; use; video; visits; web cache: cord-0024898-h156n6jj.txt plain text: cord-0024898-h156n6jj.txt item: #86 of 251 id: cord-0024923-4fx2w448 author: Ciaffi, Jacopo title: The Effect of Ketogenic Diet on Inflammatory Arthritis and Cardiovascular Health in Rheumatic Conditions: A Mini Review date: 2021 words: 5338 flesch: 26 summary: Ketogenic diet (KD) is a diet that restricts carbohydrates to a maximum of 5-10% of the total daily caloric intake. It was proposed by Dr. Wilder in 1921 as a way to induce a metabolic state similar to fasting, through the production of ketone bodies. It has been used as a treatment for epilepsy during the 20th century, but then it was abandoned due to the introduction of anti-epileptic drugs. The current literature doesn't draw conclusion about the effects of KD in rheumatic diseases. keywords: activation; activity; adipose; analysis; anti; arthritis; authors; beneficial; bhb; bodies; body; camp; carbohydrate; cardiovascular; cells; clinical; conditions; cytokines; diet; dietary; disease; effects; efficacy; evidence; factors; fasting; function; glucagon; glucose; health; il-1β; il-6; improvement; increase; induction; inflammation; inflammatory; insulin; interventions; ketogenic; ketogenic diet; ketone; levels; literature; loss; low; mediterranean; meta; metabolic; obesity; osteoarthritis; outcomes; patients; psa; psoriasis; psoriatic; reduction; resistance; results; review; rheumatoid; rheumatoid arthritis; risk; role; significant; spondylitis; studies; study; symptoms; systematic; th17; tissue; tnf; treatment; trials; weight cache: cord-0024923-4fx2w448.txt plain text: cord-0024923-4fx2w448.txt item: #87 of 251 id: cord-0025165-bmyfrglp author: Hossain, Rajib title: Lasia spinosa Chemical Composition and Therapeutic Potential: A Literature-Based Review date: 2021 words: 4797 flesch: 37 summary: Lasia spinosa (L.) is used ethnobotanically for the treatment of various diseases, including rheumatoid arthritis, inflammation of the lungs, bleeding cough, hemorrhoids, intestinal diseases, stomach pain, and uterine cancer. It is found in Asia-Bangladesh, China, the Indian subcontinent, Myanmar, Thailand, Indo-China, Indonesia, Papua New Guinea, and Laksmana in Sanskrit. keywords: acid; activity; antimicrobial; antinociceptive; antioxidant; b.w; basis; bioactive; biological; body; cancer; carotenoids; cellular; chemical; composition; compounds; content; cyp; cytotoxic; data; diabetes; different; disc; diseases; dpph; drug; effects; evidence; extract; fats; flavonoids; free; health; high; hydroalcoholic; important; increase; induced; infections; interactions; kcal/100; kinase; l. spinosa; lasia; lasia spinosa; leaf; leaves; levels; longevity; mechanisms; medicinal; medicine; methanol; mice; model; molecular; natural; nutritional; oil; oxidative; p.o; parts; pharmacological; phenolic; plant; potential; properties; protein; rats; research; review; root; scientific; significant; spinosa; stem; stress; studies; study; testosterone; therapeutic; total; toxicological; traditional; treatment; weight cache: cord-0025165-bmyfrglp.txt plain text: cord-0025165-bmyfrglp.txt item: #88 of 251 id: cord-0025437-0tntvkwn author: Brkic, Alen title: Exploring drug cost and disease outcome in rheumatoid arthritis patients treated with biologic and targeted synthetic DMARDs in Norway in 2010–2019 – a country with a national tender system for prescription of costly drugs date: 2022 words: 4803 flesch: 52 summary: In Norway, an annual tender system for the prescription of biologic and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) has been used since 2007. The number of registered RA patients increased from 4909 in 2010 to 9335 in 2019. The proportion of b/ts DMARDs treated patients achieving DAS28 remission increased from 42 to 67%. The estimated mean annual cost to treat a patient on b/tDMARD's fell by 47%, from 13.1 thousand euros (EUR in 2010) to 6.9 thousand EUR in 2019, and the mean annual costs to treat naïve patients was reduced by 75%. keywords: activity; adalimumab; annual; arthritis; available; biorheuma; biosimilar; centers; changes; clinical; cost; countries; cpi; current; das28; data; disabled; disease; drugs; duration; enabled; etanercept; eur; infliximab; lower; mean; measures; naïve; non; norway; norwegian; outcomes; patients; percentage; period; prevalence; price; reduction; reference; remission; results; rheumatoid; significant; status; study; supplementary; system; table; tender; tnfi; treatment; tsdmards; users; variables; vas; work; workers; years cache: cord-0025437-0tntvkwn.txt plain text: cord-0025437-0tntvkwn.txt item: #89 of 251 id: cord-0025521-5zqdj2cv author: Rahman, Md. Mominur title: Role of Phenolic Compounds in Human Disease: Current Knowledge and Future Prospects date: 2021 words: 14838 flesch: 28 summary: Polyphenols are secondary plant metabolites that play a vital role in protecting plants from UV radiation and disease attacks. Long-term consumption of diets high in plant polyphenols protects against cancer, cardiovascular disease, osteoporosis, and neurological diseases. Phenolic compounds can inhibit enzymes associated with the development of human diseases and have been used to treat various common ailments. keywords: absorption; ace; acetylcholine; ache; acid; action; activation; activities; activity; addition; adverse; agents; aging; aglycones; alzheimer; amyloid; angiotensin; anthocyanins; anti; antimicrobial; antioxidant; antiviral; apigenin; aromatic; arthritis; associated; atherosclerosis; benefits; binding; bioactive; bioavailability; biological; blood; body; brain; cancer; capacity; cardiovascular; catechins; cells; cellular; changes; chemical; cholinesterase; chronic; clinical; cocoa; coffee; combination; common; complications; compounds; conditions; conjugation; consumption; content; control; coumaric; critical; curcumin; current; cycle; daidzein; damage; death; derivatives; development; diabetes; dietary; diets; different; disease; disorders; drugs; effects; enzyme; epidemiological; epidermal; evaluation; evidence; example; expression; extract; factor; feature; ferulic; figure; flavones; flavonoids; food; formation; free; fruit; function; future; gallate; genistein; glucose; glycosides; grape; green; groups; growth; hacat; health; high; human; hypertension; impact; incidence; increase; induced; inflammation; inflammatory; inhibition; inhibitors; intake; interest; intestine; involved; irritation; kaempferol; keratinocytes; levels; like; lipid; liver; matter; mechanisms; mediators; medical; medicinal; melanin; melanoma; membrane; metabolic; metabolites; mice; mitochondrial; molecular; molecules; multiple; nanoparticles; natural; neurodegenerative; new; non; oil; olive; osteoporosis; oxidative; oxygen; particulate; pathways; patients; phenolic; phenolic compounds; plant; plasma; polyphenols; population; potential; prevention; primary; process; production; products; properties; protective; protein; psoriasis; quercetin; range; rats; reactions; reactive; recent; red; regions; related; release; research; response; result; resveratrol; review; rich; ring; risk; role; ros; significant; skin; small; sources; species; specific; stomach; stress; structure; studies; study; substances; symptoms; synthetic; system; table; target; tea; therapeutic; therapy; thought; tissues; treatment; type; tyrosinase; urine; vegetables; wine cache: cord-0025521-5zqdj2cv.txt plain text: cord-0025521-5zqdj2cv.txt item: #90 of 251 id: cord-0025788-0mz5umtn author: Fiehn, Christoph title: Biologikatherapie von rheumatoider Arthritis und Spondyloarthritiden date: 2022 words: 2571 flesch: 35 summary: Biologics are an integral part of modern strategies for treatment of rheumatoid arthritis (RA) and spondylarthritis (SpA), including psoriatic arthritis (PsA). Biologics produce proteins that have inhibiting effects on humoral and cellular components of the rheumatic inflammation. The safety of biologics has been intensively investigated. keywords: abatacept; aber; adalimumab; als; antikörper; antirheumatic; arthritis; auch; auf; bdmard; beginn; behandlung; bei; biologics; biologika; biologikatherapie; classes; csdmard; daher; das; dass; dem; den; der; des; die; disease; drugs; eine; empfohlen; für; haben; hemmer; hier; il-23; il-6; inhibitoren; ist; jedoch; kombination; lymphocyte; mit; mtx; möglich; nach; nicht; nur; oder; patienten; patients; psa; psoriasisarthritis; psoriatic; recommendations; remission; rheumatoid; rheumatologie; risiko; risk; rituximab; safety; sind; spa; spondylitis; standard; substance; synthetic; tab; target; therapie; tnf; tocilizumab; treatment; tumor; und; unter; use; vergleich; von; werden; wird; wirkung; zugelassen; zur cache: cord-0025788-0mz5umtn.txt plain text: cord-0025788-0mz5umtn.txt item: #91 of 251 id: cord-0027574-4yr8n5qx author: Deloch, Lisa title: Radon Improves Clinical Response in an Animal Model of Rheumatoid Arthritis Accompanied by Increased Numbers of Peripheral Blood B Cells and Interleukin-5 Concentration date: 2022 words: 9249 flesch: 50 summary: Ranon is used in the treatment of chronic inflammatory and non-inflammatory diseases such as rheumatoid arthritis. It is thought that radon modulates the anti-oxidative and the immune system. In the study, K/BxN serum-induced arthritic mice were exposed to sham or radon irradiation and found a significantly improved clinical disease progression score in the mice. keywords: alterations; analysis; animals; anti; arthritis; b cells; blood; bone; bone marrow; bxn; c57bl/6; calculated; catalase; cells; chamber; clinical; comparison; conditions; control; culture; data; dcf; dose; effects; experiments; exposure; expression; factor; figure; gas; gating; gpx1; group; hour; il-5; immune; improvement; increase; independent; inflammatory; inhalation; iqr; long; low; macrophages; mann; marrow; marrow cells; median; mice; min; mock; model; monocytes; mouse; non; nrf2; observed; oxidative; patients; peripheral; radon; radon treatment; results; ros; score; serum; significant; slight; sod1; spa; standard; statistics; study; subsets; swelling; system; test; therapy; tnfα; treatment; vivo; whitney cache: cord-0027574-4yr8n5qx.txt plain text: cord-0027574-4yr8n5qx.txt item: #92 of 251 id: cord-0027848-ectbbz5j author: Wu, Tao title: Gasdermin-E Mediated Pyroptosis—A Novel Mechanism Regulating Migration, Invasion and Release of Inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-like Synoviocytes date: 2022 words: 5610 flesch: 40 summary: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovitis accompanied by excessive release of inflammatory cytokines and destruction of bone and cartilage. Fibroblast-like synoviocytes (FLSs) are important participants in the pathogenesis of RA. Pyroptosis is a pro-inflammatory and cell lytic programmed cell death mechanism mediated by gasdermin (GSDM) family proteins. RA patients with high GSDME N-terminal expression showed higher IL-6 expression. keywords: abcam; analysis; anti; apoptosis; arthritis; article; assay; biology; blot; bone; caspase-3; cell; china; clinical; control; cytokines; data; death; developmental; domain; et al; experiments; expression; february; fibroblast; figure; flss; gasdermin; gsdme; human; hypoxia; ihc; il-6; inflammation; inflammatory; invasion; kit; knockdown; levels; like; lining; lytic; mean; mechanism; membrane; migration; novel; orth.a; patients; proliferation; protein; pyroptosis; ra flss; release; results; rheumatoid; role; samples; secretion; sirna; staining; states; study; supplementary; synovial; synovium; tissue; tnf; treatment; united; volume; western; www.frontiersin.org cache: cord-0027848-ectbbz5j.txt plain text: cord-0027848-ectbbz5j.txt item: #93 of 251 id: cord-0027854-9a3t6vf7 author: Tang, Yujun title: Yunpi Qufeng Chushi Formula for Pre-Rheumatoid Arthritis: Study Protocol for a Multiple-Center, Double-Blind, Placebo-Controlled Randomized Controlled Trial date: 2022 words: 4011 flesch: 49 summary: Yunpi Qufeng Chushi Formula for Pre-Rheumatoid Arthritis is being trialled in 13 hospitals nationwide. 390 patients ages between 18 and 70 will be randomly assigned to the intervention group (YQCF) and the placebo group. The follow-up visit will be taken every 3 months from baseline to 1 year. keywords: activity; aes; analysis; anti; antibody; arthritis; assessment; baseline; blind; ccp; center; changes; chinese; clinical; committee; criteria; data; date; definition; diagnosis; disease; dmards; double; drug; early; efficacy; et al; evaluation; follow; group; index; individuals; intervention; joint; measurement; medical; medicine; negative; patients; period; placebo; positive; pre; progression; review; rheumatoid; safety; score; study; system; tcm; therapy; time; treatment; trial; ultrasound; van; visit; yqcf; zhejiang cache: cord-0027854-9a3t6vf7.txt plain text: cord-0027854-9a3t6vf7.txt item: #94 of 251 id: cord-0027898-ljxjb2rz author: Schonfeldova, Barbora title: Synovial single-cell heterogeneity, zonation and interactions: a patchwork of effectors in arthritis date: 2021 words: 6062 flesch: 32 summary: There is still no treatment for rheumatoid arthritis. The understanding of the synovium, the affected site, is incomplete. The field of single-cell sequencing is rapidly growing. Monuclear phagocytes are important contributors to both homeostasis and inflammation. keywords: activation; analysis; arthritis; better; bone; cd34; cell; cellular; characterisation; chemokine; data; development; different; disease; distinct; endothelial; example; expression; fibroblasts; fig; function; genes; helper; heterogeneity; heterogeneous; high; homeostasis; human; immune; infiltration; inflammation; inflammatory; innervation; interactions; interstitial; joint; leukocyte; levels; ligand; like; localisation; lyve1; macrophages; markers; mertk; methods; mhcii; model; murine; neg; nervous; notch; pathology; pathways; patients; peripheral; populations; pos; positioning; profiling; protective; recent; receptor; remission; review; rheumatoid; rheumatology; rna; role; sensory; sequencing; signalling; single; spatial; specific; structural; sublining; subpopulations; subsets; synovial; synovium; system; technologies; thy1þ; tissue; transcriptomics; understanding; vascular; vasculature cache: cord-0027898-ljxjb2rz.txt plain text: cord-0027898-ljxjb2rz.txt item: #95 of 251 id: cord-0028192-a3ahbdp1 author: Park, Dong Won title: TNF inhibitors increase the risk of nontuberculous mycobacteria in patients with seropositive rheumatoid arthritis in a mycobacterium tuberculosis endemic area date: 2022 words: 4244 flesch: 37 summary: TNF inhibitors increase the risk of nontuberculous mycobacteria in patients with seropositive rheumatoid arthritis in an MTB endemic area. The risk of developing NTM after TNFI treatment was 2.108 times higher among women than among men. keywords: age; ahr; analysis; anti; area; arthritis; cases; cci; code; cohort; comorbidities; database; date; development; diagnosis; disease; endemic; factor; follow; gender; group; health; higher; impact; incidence; index; infection; korea; mtb; mycobacterial; necrosis; nhis; nontuberculous; ntm; patients; period; population; prevalence; pulmonary; ra patients; rheumatoid; rid; risk; score; south; studies; study; therapy; tnfi; treatment; tuberculosis; tumor; untreated; years cache: cord-0028192-a3ahbdp1.txt plain text: cord-0028192-a3ahbdp1.txt item: #96 of 251 id: cord-0028307-zde2yn62 author: Wu, Shan-Shan title: Network Pharmacology-Based Analysis on the Effects and Mechanism of the Wang-Bi Capsule for Rheumatoid Arthritis and Osteoarthritis date: 2022 words: 5708 flesch: 45 summary: Wang-Bi capsule (WB) is a traditional Chinese medicine (TCM-based herbal formula used in the treatment of rheumatoid arthritis (RA) and osteoarthritis (OA) in clinical practice. It is effective in ameliorating the disease symptoms of collagen II-induced RA (CIA) and monosodium iodoacetate-induced OA (MIA) in rats. keywords: acid; addition; akt; akt1; analysis; anhydroicaritin; ankle; anti; arthritis; articular; bone; cartilage; cells; china; cia; collagen; common; compounds; con; destruction; diseases; docking; effects; experimental; figure; gene; group; il-1β; induced; inflammation; inflammatory; joint; knee; level; lps; luteolin; mechanism; mia; model; molecular; network; oleanolic; osteoarthritis; pathway; pharmacology; pi3k; potential; production; protein; rats; related; results; rheumatoid; role; serum; signaling; software; study; synovial; targets; tcm; therapeutic; tnf; total; treatment; value; vitro; vivo cache: cord-0028307-zde2yn62.txt plain text: cord-0028307-zde2yn62.txt item: #97 of 251 id: cord-0028379-w4okyd70 author: Paul, Alok K. title: The Role of Medicinal and Aromatic Plants against Obesity and Arthritis: A Review date: 2022 words: 11246 flesch: 29 summary: There is a link between obesity and rheumatoid arthritis, osteoarthritis, diabetes, hypertension, cardiovascular disorders, fatty liver disease, oxidative stress, and chronic kidney diseases. In 2016, around 1.9 billion adults (aged > 18 years) were overweight. The review describes treatment options derived from medicinal, spice and aromatic plants. keywords: acid; activation; active; activities; activity; adipose; adjuvant; adults; adverse; alcoholic; analgesic; anti; antioxidant; apigenin; aromatherapy; aromatic; arthritis; ayurvedic; blind; blood; body; boswellia; cardiovascular; cartilage; cells; chemical; cholesterol; chronic; clinical; collagen; common; complete; composition; constituents; consumption; curcuma; curcumin; cytokines; daily; damage; day; development; diabetes; diet; disease; disorders; domain; double; drugs; effects; efficacy; elderly; essential; essential oil; evaluation; evidence; experimental; expression; extract; factor; fat; fatty; figure; flavonoids; food; formulation; fraction; freund; fruits; generation; ginger; grade; group; gut; health; herbal; high; human; il-1β; il-6; immune; improved; index; induced; inflammasome; inflammation; inflammatory; inflammatory cytokines; influence; inhibits; intake; isolated; joint; knee; lavender; leaves; levels; like; lipid; liver; long; low; macrophages; management; mechanisms; medicinal; medicines; metabolic; mice; model; natural; new; nigella; nlrp3; non; nsaids; obese; obesity; officinalis; oil; oils; oral; osteoarthritis; overweight; oxidative; pain; parts; pathogenesis; pathway; patients; people; period; placebo; plants; plasma; population; potential; preclinical; prevotella; production; properties; protective; quercetin; ra patients; randomized; rats; recent; receptor; reduced; response; review; rheumatoid; rheumatoid arthritis; role; roots; safety; sativa; secretion; serrata; steroidal; stress; studies; study; symptoms; syndrome; synovial; systematic; table; terminalia; therapeutic; tissues; tnf; total; traditional; treatment; trial; use; weeks; weight; women; years; zingiber cache: cord-0028379-w4okyd70.txt plain text: cord-0028379-w4okyd70.txt item: #98 of 251 id: cord-0028500-w35igre9 author: Jung, Seung Min title: Targeted Immunotherapy for Autoimmune Disease date: 2022 words: 8084 flesch: 25 summary: In the past few decades, biological drugs and small molecule inhibitors targeting inflammatory cytokines, immune cells, and intracellular kinases have become the standard-of-care to treat autoimmune diseases. B cell depletion therapy using anti-CD20 mAbs has shown promising results in patients with neuroinflammatory diseases, and inhibition of B cell survival factors is approved for the treatment of systemic lupus erythematosus. Small molecule kinase inhibitors targeting the JAK family have garnered great interest in the field of autoimmune and hematologic diseases. keywords: activation; active; anti; antibody; arthritis; associated; autoantigens; autoimmune; autoimmune diseases; autoimmunity; b cell; baff; binding; blind; car; cd20; cd40; cells; clinical; current; cytokine; dcs; depletion; development; differentiation; diseases; domain; dose; double; drugs; effector; effects; efficacy; erythematosus; expression; factors; family; function; gp130; high; ifn; ifns; iii; il-1; il-23; il-6; immunotherapy; inflammation; inflammatory; inhibition; inhibitors; innate; intracellular; jak; key; kinase; lupus; mabs; molecular; molecules; monoclonal; multiple; oral; pathogenesis; pathogenic; pathways; patients; phase; placebo; production; proliferation; protein; psoriasis; randomised; recent; receptor; response; results; rheumatoid; role; safety; severe; signaling; sle; specific; stimulatory; study; survival; syndrome; systemic; t cells; targeted; targets; th17; therapeutic; therapies; therapy; tnf; tolerance; tolerogenic; treatment; treg; trial; type cache: cord-0028500-w35igre9.txt plain text: cord-0028500-w35igre9.txt item: #99 of 251 id: cord-0028740-3gf4cbky author: Pan, Zijian title: Role of the CXCL13/CXCR5 Axis in Autoimmune Diseases date: 2022 words: 11465 flesch: 33 summary: CXCL13 is a B-cell chemokine produced mainly by mesenchymal lymphoid tissue organizer cells, follicular dendritic cells, and human T follicular helper cells. It plays an important role in lymphoid neogenesis, lymphoid organization, and immune responses. It is implicated in the pathogenesis of several autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, primary Sjögren’s syndrome and myasthenia gravis. keywords: activation; activity; addition; analysis; angiogenesis; anti; antibodies; antibody; arthritis; autoantibodies; autoantibody; autoimmune; autoimmune diseases; axis; b cells; biomarker; blockade; cells; chemokine; chronic; clinical; consistent; cvid; cxcl13; cxcl13 expression; cxcl13 levels; cxcr5; cxcr5 axis; cytokines; dendritic; dependent; development; diseases; downstream; eae; early; ectopic; effect; elevated; elss; endothelial; erythematosus; expression; factor; fibrosis; follicles; follicular; formation; gcs; glands; gravis; helper; homing; human; ibd; il-21; impaired; infiltration; inflammation; inflammatory; joint; key; kinase; lesions; levels; like; lupus; lymphocyte; lymphoid; lymphoma; lymphotoxin; macrophages; mice; migration; model; molecule; mouse; multiple; myasthenia; neogenesis; nephritis; novel; organization; organs; pathogenesis; pathway; patients; peripheral; plasma; positive; potential; presence; primary; production; progressive; proliferation; protein; pss; receptor; recruitment; regulatory; renal; responses; results; rheumatoid; role; salivary; sclerosis; secondary; serum; serum cxcl13; severity; signaling; sjögren; skin; sle; specific; structures; studies; study; syndrome; synovial; systemic; t cells; target; terminal; tfh; tfh cells; th17; therapeutic; thymic; thymus; tissues; tph; treatment; type cache: cord-0028740-3gf4cbky.txt plain text: cord-0028740-3gf4cbky.txt item: #100 of 251 id: cord-0029264-66kjhzwx author: Calderón Espinoza, Ivette title: Suicide Risk in Rheumatoid Arthritis Patients is Associated With Suboptimal Vitamin D Levels date: 2022 words: 3108 flesch: 39 summary: Suicide risk in Rheumatoid arthritis (RA) patients is associated with low vitamin D levels. RA is one of the most prevalent chronic inflammatory autoimmune diseases that can cause disability if not diagnosed and treated on time. In Mexico, the suicide rate has grown from 1 in 13 in 1970 to 13 in 2017. keywords: activity; analysis; anxiety; arthritis; association; clinical; correlation; d levels; deficient; depression; disease; disorders; figs; frequency; hads; haq; health; high; hospital; ideation; inadequate; levels; life; low; patients; plutchik; prevalence; quality; questionnaire; raqol; rheumatoid; risk; scale; score; serum; studies; study; suicidal; suicide; supplementation; symptoms; test; variables; vitamin; vitamin d cache: cord-0029264-66kjhzwx.txt plain text: cord-0029264-66kjhzwx.txt item: #101 of 251 id: cord-0029277-1epj9xy2 author: Gray, Anna L. title: Role of extracellular matrix proteoglycans in immune cell recruitment date: 2022 words: 5116 flesch: 33 summary: Leucocyte recruitment is a critical component of the immune response. Proteoglycans play a similar role in inflammatory diseases such as rheumatoid arthritis, atherosclerosis and cancer. A review summarizes what is currently known about the role of the extracellular matrix in the different stages of leucocytes' recruitment. keywords: ability; acid; adhesion; binding; blood; cells; chains; chemokine; cytokine; different; disease; endothelial; example; extracellular; function; gag; gags; glycocalyx; glycosaminoglycan; gradients; heparan; human; immune; important; inflammation; inflammatory; interactions; key; leucocyte; leucocyte recruitment; likely; matrix; mechanistic; mediate; membrane; migration; monocyte; neutrophils; number; patterns; potential; process; protein; proteoglycans; range; receptor; recruitment; research; response; role; selectin; shedding; signalling; soluble; specific; structure; studies; sulfate; sulphate; sulphation; surface; syndecan-1; system; tgf; tissues; understanding; vascular; vasculature; vessels cache: cord-0029277-1epj9xy2.txt plain text: cord-0029277-1epj9xy2.txt item: #102 of 251 id: cord-0029401-317zhrki author: Zeng, Liuting title: Efficacy and Safety of Mesenchymal Stem Cell Transplantation in the Treatment of Autoimmune Diseases (Rheumatoid Arthritis, Systemic Lupus Erythematosus, Inflammatory Bowel Disease, Multiple Sclerosis, and Ankylosing Spondylitis): A Systematic Review and Meta-Analysis of Randomized Controlled Trial date: 2022 words: 9467 flesch: 39 summary: There are 18 RCTs involving 5 autoimmune diseases and mesenchymal stem cell transplantation was found to be effective for RA, SLE, inflammatory bowel disease, ankylosing spondylitis, and multiple sclerosis. There were no obvious adverse events of MSCs. More studies are needed to confirm the conclusions. keywords: activity; addition; adipose; administration; adverse; allogeneic; analysis; arthritis; autoimmune; autoimmune diseases; bias; blood; bone; bowel; cells; clinical; colitis; control; cord; current; cytokines; damage; data; differentiation; disease; effective; effects; efficacy; encephalomyelitis; erythematosus; events; experimental; expression; factors; figure; function; group; heterogeneity; human; immunomodulatory; inflammatory; infusion; international; intestinal; intravenous; low; lupus; lymphocytes; marrow; mesenchymal; mesenchymal stem; method; mice; model; molecules; msc; mscs; multiple; new; number; pain; patients; proliferation; protein; rate; rcts; regulation; regulatory; related; repair; research; response; results; review; rheumatoid; risk; safety; sclerosis; serum; sle; spondylitis; statistical; stem; stem cells; stromal; studies; symptoms; systemic; t cells; test; therapeutic; therapy; tissue; total; transplantation; treatment; ulcerative; umbilical; use; variety cache: cord-0029401-317zhrki.txt plain text: cord-0029401-317zhrki.txt item: #103 of 251 id: cord-0029472-ttytoz3v author: Torequl Islam, Muhammad title: Activities and Molecular Mechanisms of Diterpenes, Diterpenoids, and Their Derivatives in Rheumatoid Arthritis date: 2022 words: 7558 flesch: 32 summary: Diterpenes and their derivatives have many biological activities, including anti-inflammatory and immunomodulatory effects. This study summarizes the literature about diterpened derivatives acting against rheumatoid arthritis (RA) until 31 August 2021. keywords: 5r)-5; acid; activation; active; activities; activity; adjuvant; agents; andrographolide; animals; anti; apoptosis; arthritis; blood; bone; carnosic; cartilage; cells; chemokines; chondrocytes; clinical; collagen; complete; complex; compounds; cytokines; days; dependent; derivatives; disease; diterpenes; diterpenoids; effects; experimental; expression; factor; female; fibroblast; findings; fls; fluid; freund; gene; ginkgolide; hand; human; hydroxytriptolide; iia; il-1β; il-6; improved; induced; inflammation; inflammatory; inhibited; inhibits; inos; jnk; joints; kinase; levels; like; lncrna; long; lps; macrophages; male; marine; medicinal; methotrexate; mice; models; natural; neutrophil; novel; nsaids; opg; osteoclastogenesis; pathway; patients; peripheral; platelet; potential; production; proliferation; promising; protein; ra patients; rankl; rats; receptor; research; response; retinoic; rheumatoid; rheumatoid arthritis; sclareol; secretion; serum; signaling; study; synovial; synoviocytes; tanshinone; test; therapeutic; tissues; tnf; treatment; triptolide; type; vivo cache: cord-0029472-ttytoz3v.txt plain text: cord-0029472-ttytoz3v.txt item: #104 of 251 id: cord-0029554-cm1j3vc9 author: Chen, Ying title: Dimethylamino group modified polydopamine nanoparticles with positive charges to scavenge cell-free DNA for rheumatoid arthritis therapy date: 2022 words: 8187 flesch: 48 summary: Chen, Ying, Wang, Yonglin, Jiang, Xianfang, Cai, Jinhong, Chen, Yuting, Huang, Hanji, Yang, Yuan, Zheng, Li, Zhao, Jinmin, Gao, Ming have developed nanoparticles with positive charges to scavenge cell-free DNA for rheumatoid arthritis therapy. keywords: ability; affinity; analysis; arthritis; bands; binding; bis; bone; capacity; cartilage; cationic; cells; cfdna; charge; china; cia; close; concentration; cpg; cy5; cytotoxicity; data; day; dead; density; destruction; different; dimethylamino; dna; dps; effects; expression; factors; fig; fluorescent; free; gel; gene; group; high; il-6; images; inflammation; inflammatory; inos; intensity; japan; joints; knee; levels; lps; medium; min; mmp-13; modification; modified; nanoparticles; normal; nps; pbs; pda; pda nps; polydopamine; positive; potential; processing; ra group; rats; results; rheumatoid; scavengers; serum; similar; solution; staining; swelling; synovial; therapeutic; therapy; time; tnf; treatment; vivo cache: cord-0029554-cm1j3vc9.txt plain text: cord-0029554-cm1j3vc9.txt item: #105 of 251 id: cord-0029814-v6t9trz7 author: Watanabe, Ryu title: Perspectives of JAK Inhibitors for Large Vessel Vasculitis date: 2022 words: 3439 flesch: 33 summary: Vasculitis is an inflammation of the blood vessels caused by autoimmunity and/or autoinflammation. Glucocorticoids and cyclophosphamide are the standard of care. B-cell depletion therapy with rituximab has become available for treating antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Avacopan, an inhibitor of the complement 5a receptor, was shown to have high efficacy in remission induction against AAV. In LVV, tocilizumab, an IL-6 receptor antagonist, was effective in suppressing relapse and has steroid-sparing effects. Janus kinase (JAK) inhibitors have emerged as therapeutic keywords: arteritis; bdmards; blood; cd4; cell; clinical; cytokines; disease; effective; efficacy; factor; gca; giant; high; ifns; il-6; inflammation; inhibitors; jak; jak inhibitors; large; lesions; long; lvv; pathway; patients; promising; receptor; refractory; remission; results; rheumatoid; risk; safety; stat; study; tak; takayasu; therapy; tofacitinib; treatment; trial; type; vascular; vasculitis; vessel; zoster cache: cord-0029814-v6t9trz7.txt plain text: cord-0029814-v6t9trz7.txt item: #106 of 251 id: cord-0030225-wddgamb0 author: Han, Maozhen title: The Potential of Gut Microbiota Metabolic Capability to Detect Drug Response in Rheumatoid Arthritis Patients date: 2022 words: 6122 flesch: 31 summary: Gut microbiota plays an essential role in the development of rheumatoid arthritis (RA) and affects drug responses. Han, Maozhen, Zhang, Na, Mao, Yujie, Huang, Bingbing, Ren, Mengfei, Peng, Zhangjie; Bai, Zipeng, Chen, Long, Liu, Yan, Wang, Shenghai, Cheng, Zhixiang studied methotrexate (MTX) as an example of RA drugs. They found that the gut microbiota harbored various genes involved in MTX metabolism in healthy individuals and RA patients. Their findings provide bases for clinical management of RA and other gut-related diseases. keywords: analysis; arthritis; biomarkers; bioproject; capability; clinical; clinical treatment; cohorts; communities; compositions; corresponding; database; datasets; development; different; diseases; drug; drug metabolism; dysbiosis; essential; et al; figure; functional; genes; groups; gut; gut metagenome; gut microbial; gut microbiota; healthy; host; human; human gut; individuals; information; interactions; intestinal; mechanism; metabolism; metagenome; microbial; microbiome; model; mtx; mtx metabolism; patients; potential; proteins; ra patients; related; response; results; rheumatoid; role; samples; studies; study; taxonomical; training; treatment cache: cord-0030225-wddgamb0.txt plain text: cord-0030225-wddgamb0.txt item: #107 of 251 id: cord-0030275-bpdng4wm author: Pulito-Cueto, Verónica title: Angiogenic T Cells: Potential Biomarkers for the Early Diagnosis of Interstitial Lung Disease in Autoimmune Diseases? date: 2022 words: 4256 flesch: 47 summary: Angiogenic T cells (TAng) are potential biomarkers for the early diagnosis of interstitial lung disease in autoimmune diseases. TAng frequency was found between AD-ILD(+) and IPF, being in both cases lower than that observed in AD/ILD(+ and HC/HC. keywords: angiogenic; anti; arthritis; autoimmune; biomarkers; blood; cells; clinical; criteria; diagnosis; disease; early; endothelial; epc; fibrosis; figure; frequencies; frequency; hrct; ild; interstitial; involvement; ipf; lower; lung; patients; pattern; potential; presence; progenitor; pulmonary; relationship; results; rheumatoid; role; sclerosis; spain; ssc; study; systemic; table; tang; underlying; vascular; vasculopathy; vegf cache: cord-0030275-bpdng4wm.txt plain text: cord-0030275-bpdng4wm.txt item: #108 of 251 id: cord-0030481-sjadkhd6 author: Pistorius, Kimberly title: MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis date: 2022 words: 13167 flesch: 38 summary: MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis. MCTR is negatively correlated with joint disease activity and severity in RA patients. Arg-1 inhibition reversed both the anti-arthritic and tissue reparative actions of MCTr3-reprogrammed monocytes. keywords: ability; acid; actions; activities; activity; administration; analysis; anti; approach; arthritic mice; arthritis; biolegend; bone; buffer; bxn; c57bl/6; cartilage; cells; clinical; cohort; collagen; component; concentrations; cytometry; damage; data; day; days; destruction; development; differences; dilution; disease; dmem; dpbs; efferocytosis; epigenetic; etoh; evaluation; experiments; expression; factor; fbs; femur; figure; findings; flow; genes; group; heads; hours; human; immune; increase; inflammation; inflammatory; inflammatory arthritis; inhibitor; injection; isolated; joint; joint inflammation; joint protective; key; kit; lipid; macrophages; markers; marrow; mctr3; mdm; mechanisms; mediators; methanol; mice; min; minutes; model; monocytes; mononuclear; mouse; murine; observed; oedema; organ; pathway; patients; paws; phase; phenotype; pkh67; plasma; present; propagation; protective; protective activities; protein; purpose; receiving; reduction; regeneration; regulated; repair; reparative; reprogrammed; reprogramming; resolution; resolving; responses; results; rheumatoid; role; safranin; sample; scores; serum; severity; shift; significant; single; sirna; spm; staining; statistical; studies; synovial; system; table; test; therapeutics; time; tissue; tnf; total; treated; treatment; upregulation; vehicle; vivo; vol; volume; ° c cache: cord-0030481-sjadkhd6.txt plain text: cord-0030481-sjadkhd6.txt item: #109 of 251 id: cord-0030844-qv8oznba author: Song, Jihyeon title: Formulation of Glycyrrhizic Acid-based Nanocomplexes for Enhanced Anti-cancer and Anti-inflammatory Effects of Curcumin date: 2022 words: 4422 flesch: 43 summary: In this study, nanocomplexes composed of glycyrrhizic acid (GA) derived from the root of the licorice plant were formulated for the delivery of curcumin (CUR). They produced nanosized complexes with a size of 164.8 ± 51.7 nm, which greatly enhanced the solubility of CUR in aqueous solution. Most of the CURs were released within 12 h. They exhibited excellent intracellular uptake in human breast cancer cells, indicating enhanced anti-cancer effects compared to free CUR. keywords: acid; activity; anti; antioxidant; aqueous; arthritis; cancer; cells; collagen; concentration; cur; cur nanocomplexes; cur weight; curcumin; drug; effects; enhanced; fig; fluorescence; formulation; free; glycyrrhizic; il-1β; inflammatory; interactions; intracellular; levels; macrophages; mdr; mice; model; nanocomplexes; pbs; previous; ratios; raw264.7; solubility; solution; study; tnf; treatment; uptake; vitro; vivo; wavelength; weight cache: cord-0030844-qv8oznba.txt plain text: cord-0030844-qv8oznba.txt item: #110 of 251 id: cord-0030918-jxxzx886 author: Han, Peng title: Serum Antigenome Profiling Reveals Diagnostic Models for Rheumatoid Arthritis date: 2022 words: 4081 flesch: 40 summary: The study aimed to investigate the serum antigens profiling in rheumatoid arthritis (RA) and determine potential diagnostic biomarkers using label-free proteomic technology implemented with machine-learning algorithm. It identified 62, 71, and 49 DEPs in RA, ACPA-positive RA, and ACPA -negative RA, respectively. keywords: acpa; algorithm; alpha; analysis; antibodies; antigenome; antigens; arthritis; biomarkers; capture; classification; clinical; cohort; column; complement; controls; data; deps; diagnostic; disease; early; figure; forest; free; function; group; healthy; high; igg; immune; interaction; label; learning; like; machine; mass; model; negative; negative ra; networks; novel; patients; peptide; positive; positive ra; potential; profiling; progression; protein; proteomic; ra patients; random; research; response; rheumatoid; saa2; samples; serum; single; specific; spectrometry; study; treatment cache: cord-0030918-jxxzx886.txt plain text: cord-0030918-jxxzx886.txt item: #111 of 251 id: cord-0030919-jy3cyl42 author: Ma, Yuanchen title: Accurate Machine Learning Model to Diagnose Chronic Autoimmune Diseases Utilizing Information From B Cells and Monocytes date: 2022 words: 5322 flesch: 36 summary: Systemic lupus erythematosus (SLE), multiple sclerosis (MS), and rheumatoid arthritis (RA) are chronic autoimmune diseases associated with progressive widespread organ damage. Diagnosing SLE, MS, and RA is a challenging process that relies on a set of criteria. The average time from symptom onset to diagnosis confirmation was two years. keywords: accuracy; accurate; analysis; arthritis; auc; autoimmune; bulk; cellchat; cells; cellular; chronic; cluster; cohort; cross; crucial; data; datasets; development; diagnosis; diseases; donors; early; efficient; erythematosus; expression; feature; figure; forest; gene; healthy; healthy donors; inflammatory; information; input; integration; interferon; learning; learning model; lupus; machine; machine learning; mathematical; model; monocytes; multiple; pairs; patients; patterns; pbmc; powerful; random; results; rheumatoid; rna; samples; sclerosis; scrna; seq; seurat; signaling; single; sle; sle patients; specific; step; studies; study; subpopulations; systemic; talking; version cache: cord-0030919-jy3cyl42.txt plain text: cord-0030919-jy3cyl42.txt item: #112 of 251 id: cord-0031594-udo2obt1 author: Athanassiou, Lambros title: The Immunomodulatory Properties of Vitamin D date: 2022 words: 3393 flesch: 26 summary: Vitamin D has both immunostimulatory and immunomodulatory effects on the immune system. Vitamin D deficiency has been linked to the development of several autoimmune/inflammatory diseases, such as systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. It is involved in the regulation of the innate immunity. keywords: activation; activity; adaptive; antigen; antimicrobial; arthritis; autoimmune; bowel; cathelicidin; cells; defence; deficiency; dendritic; development; differentiation; dihydroxyvitamin; disease; effects; evidence; expression; function; human; hydroxylase; immune; immunity; immunomodulatory; inflammatory; innate; lupus; macrophages; monocytes; multiple; patients; production; receptor; response; rheumatoid; role; sclerosis; skin; system; systemic; tolerance; treatment; tuberculosis; vdr; vitamin; vitamin d cache: cord-0031594-udo2obt1.txt plain text: cord-0031594-udo2obt1.txt item: #113 of 251 id: cord-0031595-y368u2ek author: Athanassiou, Panagiotis title: Vitamin D Deficiency in Primary Sjögren’s Syndrome: Association with Clinical Manifestations and Immune Activation Markers date: 2022 words: 1511 flesch: 27 summary: Vitamin D deficiency is related to the development of autoimmune disorders. Sjögren’s syndrome is a systemic autoimmune disease affecting the exocrine glands. The aim of the study is to measure serum vitamin D levels in consecutive patients with primary SJögren's syndrome and investigate the relationship between the levels and the presence of immunologic markers. keywords: activity; agent; arthritis; athanassiou; autoimmune; clinical; cohort; consecutive; data; deficiency; disease; immune; involvement; levels; low; markers; multiple; neuropathy; patients; presence; primary; rheumatoid; sclerosis; sjögren; syndrome; systemic; thyroid; vitamin cache: cord-0031595-y368u2ek.txt plain text: cord-0031595-y368u2ek.txt item: #114 of 251 id: cord-0031693-frnv0ta8 author: Miše, Joško title: Rituximab - Progress but Still Not a Final Resolution for Pemphigus Patients: Clinical Report From a Single Center Study date: 2022 words: 4710 flesch: 43 summary: Pemphigus is a rare autoimmune disease with an incidence in Croatia of 3.7 new patients per 1 million inhabitants per year. Rituximab emerged as the first-line therapeutic option for pemophigus due to its ability to induce remission by depleting peripheral B lymphocytes. A single-center, retrospective study was conducted on 19 patients treated with RITUXIMAB following a rheumatoid arthritis dosing protocol between October 2015 and March 2021. 13 out of 19 patients experienced complete remission at some point during the study, while there were no non-responders. keywords: adverse; anti; antibodies; cell; center; clinical; complete; complete remission; cycle; data; day; desmoglein; disease; dsg; efficacy; events; follow; infusion; lesions; levels; line; long; maintenance; management; mean; minimal; months; new; outcomes; patients; pdai; pemphigus; prednisone; protocol; rates; relapse; remission; response; retrospective; rituximab; rituximab cycle; second; significant; single; studies; study; systemic; term; therapy; time; treatment; vulgaris cache: cord-0031693-frnv0ta8.txt plain text: cord-0031693-frnv0ta8.txt item: #115 of 251 id: cord-0031702-07imrw74 author: Anaparti, Vidyanand title: Utility of Baseline Transcriptomic Analysis of Rheumatoid Arthritis Synovium as an Indicator for Long-Term Clinical Outcomes date: 2022 words: 5629 flesch: 36 summary: Anaparti, Vidyanand, Wiens, Dana, O'Neil, Hubbard, Erika, Smolik, Irene, Hitchon, Peter E., El-Gabalawy, Hani studied the baseline synovial transcriptome from early inflammatory arthritis patients (EIA) to identify pretreatment biomarkers that could potentially provide insights into long-term functional outcomes of rheumatoid arthritis (RA). They identified 5 differentially expressed genes (DEGs) in EIA patients. keywords: advanced; analysis; anti; applied; arthritis; baseline; biomarkers; biopsies; biopsy; cell; clinical; clustering; cohort; correlation; crp; data; degs; disability; disease; dmard; duration; early; eia; expression; figure; follow; functional; gene; group; heterogeneity; high; immune; individuals; inflammation; inflammatory; joint; levels; long; longitudinal; low; matrix; mhaq; microarray; mmp; mmp-1; modules; molecular; mrna; naïve; needle; network; outcomes; patients; protein; relative; research; response; results; rheumatoid; rna; samples; scores; short; signatures; significant; specific; study; supplementary; synovial; synovium; term; therapy; tissue; total; transcriptomic; treatment; visit; wgcna cache: cord-0031702-07imrw74.txt plain text: cord-0031702-07imrw74.txt item: #116 of 251 id: cord-0032148-k5818jgj author: Walha, Roua title: The effects of custom-made foot orthoses on foot pain, foot function, gait function, and free-living walking activities in people with psoriatic arthritis (PsA): a pre-experimental trial date: 2022 words: 7898 flesch: 45 summary: The pre-experimental trial of custom-made foot orthoses (CFO) in people with psoriatic arthritis (PsA) found significant improvements in foot pain and foot function after 7 weeks of CFO use. Large-scale and controlled studies are needed to confirm the findings. keywords: active; activities; activity; analysis; ankle; apa; arthritis; average; baseline; cadence; cfo; changes; clinical; control; correlation; custom; daily; data; day; differences; different; disability; disease; duration; effectiveness; effects; ffi; fig; findings; foot; foot function; foot orthoses; foot pain; free; function; fwa; gait; gait function; health; instrumented; intensity; intervention; large; levels; limb; living; lower; mean; meta; min; mobility; nrs; number; orthoses; pain; parameters; participants; patients; people; period; physical; points; pre; problems; psa; psoriatic; recorded; related; results; review; rheumatoid; score; significant; size; speed; steps; stp; studies; study; systematic; test; time; total; trial; use; walking; wearing; week; years cache: cord-0032148-k5818jgj.txt plain text: cord-0032148-k5818jgj.txt item: #117 of 251 id: cord-0032217-lkowb3hk author: Tardella, Marika title: A retrospective study of the efficacy of JAK inhibitors or abatacept on rheumatoid arthritis-interstitial lung disease date: 2022 words: 4098 flesch: 38 summary: The study looked at the effectiveness of Janus-kinase inhibitors (JAKis) or abatacept (ABA) in patients with rheumatoid arthritis-interstitial lung disease (RA-ILD). It found that treatment with JAKis or ABA was related to stability or improvement of RA-ILD in 83.9% and 88.6% of patients, respectively. keywords: aba; analysis; anti; arthritis; baricitinib; cam; cases; clinical; connective; current; data; disease; dmards; dose; drugs; duration; efficacy; et al; fibrosis; fibrotic; group; hrct; ild; improved; improvement; inhibitors; interstitial; jakis; joint; lung; mean; methotrexate; months; multivariate; nintedanib; patients; percentage; progression; pulmonary; results; rheumatoid; rheumatology; risk; safety; salaffi; smoking; stable; study; test; therapy; time; tissue; tofacitinib; treatment; trial; variables; worsened cache: cord-0032217-lkowb3hk.txt plain text: cord-0032217-lkowb3hk.txt item: #118 of 251 id: cord-0032373-buo6r5p9 author: Bouhuys, Marleen title: De-Escalation of Anti-Tumor Necrosis Factor Alpha Agents and Reduction in Adverse Effects: A Systematic Review date: 2022 words: 5269 flesch: 50 summary: De-escalation of anti-Tumor Necrosis Factor Alpha (TNF-α) agents does not reduce infections or skin reactions among patients with inflammatory conditions. It should not be recommended for the sole purpose of reducing drug-related adverse effects. keywords: adalimumab; adverse; agents; anti; arthritis; bias; bowel; data; difference; disease; dose; dosing; effects; escalated; escalation; etanercept; events; group; incidence; infections; inflammatory; information; interval; low; manifestations; meta; non; occurrence; patients; psoriasis; quality; randomized; rcts; reactions; reduction; remission; results; review; rheumatoid; risk; skin; standard; studies; study; systematic; table; tnf; treatment; trial; weeks cache: cord-0032373-buo6r5p9.txt plain text: cord-0032373-buo6r5p9.txt item: #119 of 251 id: cord-0032528-4mqkkx0n author: Biswas, Isha title: Content, Structure and Delivery Characteristics of Yoga Interventions for Managing Rheumatoid Arthritis: A Systematic Review Protocol date: 2022 words: 4394 flesch: 41 summary: The global burden of rheumatoid arthritis among adults is rising. This systematic review aims to synthesise the content, structure and delivery characteristics of effective yoga interventions for managing arthritis. Randomised controlled trials assessing the effectiveness of yoga interventions will be included in the review. keywords: activity; adults; analysis; arthritis; baseline; body; breathing; characteristics; cochrane; components; content; data; delivery; diagnosis; disease; effective; effectiveness; effects; factors; following; function; global; group; health; inflammation; interventions; joint; life; major; meta; outcomes; pain; pharmacological; physical; practices; prisma; protocol; rcts; related; reporting; review; reviewers; rheumatoid; rheumatoid arthritis; risk; scale; search; sessions; strategies; stress; structure; studies; study; symptoms; systematic; systematic review; time; treatment; trials; type; yoga; yoga interventions cache: cord-0032528-4mqkkx0n.txt plain text: cord-0032528-4mqkkx0n.txt item: #120 of 251 id: cord-0032691-sgucvmzt author: Dijkshoorn, Bas title: Cardiovascular Disease Risk in Rheumatoid Arthritis Anno 2022 date: 2022 words: 5093 flesch: 31 summary: Rheumatoid arthritis (RA) is the most prevalent chronic inflammatory joint disease with a prevalence of 460 per 100,000 people. RA is characterized by chronic and destructive synovitis, leading to irreversible joint damage. RA also causes problems beyond the joints, such as interstitial lung disease, vasculitis and cardiovascular disease. Anti-rheumatic medication partly reduces the CVD risk in RA patients. keywords: activity; analysis; anti; arthritis; atherosclerosis; cardiovascular; cells; cholesterol; clinical; cvd; cytokines; development; diabetes; disease; dose; drugs; effects; endothelial; events; factors; general; group; hdl; higher; hypertension; il-6; inflammation; inflammatory; inhibitors; jak; levels; low; macrophages; meta; metabolic; methotrexate; mtx; necrosis; non; patients; plaque; population; pro; ra patients; reduced; reduction; review; rheumatoid; rheumatoid arthritis; risk; role; screening; smoking; studies; study; systemic; tnf; tofacitinib; traditional; treatment; trial; years cache: cord-0032691-sgucvmzt.txt plain text: cord-0032691-sgucvmzt.txt item: #121 of 251 id: cord-0032906-7zlx183p author: Robak, Ewa title: Bruton’s Kinase Inhibitors for the Treatment of Immunological Diseases: Current Status and Perspectives date: 2022 words: 11678 flesch: 37 summary: Bruton's tyrosine kinase (BTK) inhibitors have changed the management of patients with B-cell lymphoid malignancies. Ibrutinib is the first covalent irreversible BTK inhibitor approved in 2013 as a breakthrough therapy for chronic lymphocytic leukemia patients. BTK inhibitors have been investigated in various autoimmune disorders, including autoimmune hemolytic anemia, immune thrombocytopenia, multiple sclerosis, pemphigus vulgaris, rheumatoid arthritis, systemic lupus erythematosus, Sjögren’s disease, and chronic spontaneous urticaria. keywords: acalabrutinib; activation; active; activity; addition; agents; aiha; allergic; anti; arthritis; associated; autoantibodies; autoantibody; autoimmune; binding; blind; blood; bms-986142; bone; branebrutinib; bruton; bruton tyrosine; btk; btk inhibitors; btkis; cell; chronic; clinical; cll; covalent; daily; dependent; development; disease; disorders; dose; double; drug; effective; effects; efficacy; evobrutinib; fenebrutinib; generation; group; gvhd; healthy; human; ibrutinib; ic50; ige; induced; inflammation; inflammatory; inhibited; inhibitor; inhibits; investigation; itp; kinase; kinase inhibitor; leukemia; lupus; lymphocytic; malignancies; mice; models; mouse; multiple; new; non; novel; occupancy; ongoing; oral; patients; pemphigus; phase; placebo; platelet; poseltinib; potent; potential; preclinical; primary; production; randomized; recent; receptor; reduced; remibrutinib; response; results; reversible; rheumatoid; rilzabrutinib; role; safety; sclerosis; selective; selectivity; signaling; significant; skin; sle; spebrutinib; specific; studies; study; systemic; table; target; tas5315; therapy; tirabrutinib; tolebrutinib; treatment; trial; tyrosine; tyrosine kinase; usa; vivo; volunteers; weeks; zanubrutinib cache: cord-0032906-7zlx183p.txt plain text: cord-0032906-7zlx183p.txt item: #122 of 251 id: cord-0034062-3hl8scyi author: Parke, A. title: The pathogenesis of inflammatory disease: Surgical shock and multiple system organ failure date: 1995 words: 6342 flesch: 27 summary: Parke and V. Parke discuss the role of oxidative stress and microcirculatory arrest in promoting MSOF, and the antioxidant defence system, GSH, the antioxidant vitamins, A, C and E, and fibronectin in preventing this. They also discuss the relationship between surgical shock and MSOF. keywords: acid; activation; activity; acute; anaesthesia; antioxidant; ascorbic; associated; blood; cells; chemical; chronic; complement; complex; cycling; cytochrome; cytokines; damage; defence; detoxication; disease; effects; eicosanoids; endothelial; enzymes; ether; exposure; factor; failure; fasting; figure; formation; free; function; futile; generation; glutathione; gsh; hepatic; il-1; il-6; immune; induction; infection; inflammation; inflammatory; injury; iron; ischaemia; kidney; leucocyte; lipid; liver; loss; macrophages; major; mechanisms; mediators; molecular; msof; multiple; necrosis; neutrophils; oil; organ; oxidative; oxygen; p450; peroxidation; platelets; production; radical; rat; rats; release; renal; reperfusion; response; role; ros; shock; specific; stress; substrate; superoxide; surgical; syndrome; system; systemic; tbar; tissue; toxic; toxicity; trap; trauma; tryptophan; vascular cache: cord-0034062-3hl8scyi.txt plain text: cord-0034062-3hl8scyi.txt item: #123 of 251 id: cord-0034237-zyiqigck author: DiUlio, Maggie title: Veterinary Immunology and Serology: Clinical Laboratory Diagnostics date: 1999 words: 2336 flesch: 39 summary: DiUlio, Maggie and Maggie discuss the diagnostic procedures in veterinary immunology, serology, and infectious diseases. The number of species that might be included in veterinary diagnostics is almost limitless, but for the sake of brevity only the most common (canine, feline, and equine) are included. keywords: adult; ana; animals; antibodies; antibody; antigen; assay; autoimmune; blood; canine; cells; clinical; common; coronavirus; diagnostic; disease; domestic; elisa; feline; fip; fluorescent; heartworm; immune; immunoglobulin; immunology; infection; laboratory; method; procedures; region; serology; species; specific; system; techniques; test; transfer; transfusion; veterinary; worms cache: cord-0034237-zyiqigck.txt plain text: cord-0034237-zyiqigck.txt item: #124 of 251 id: cord-0034758-vqeeaagp author: Hoang, Mai P. title: Vasculitis date: 2020 words: 14499 flesch: 34 summary: Vasculitis is characterized by inflammation and necrosis. It can present clinically as urticaria, purpura, papules, nodules, erythema, ulcer, infarct, or livedo reticularis. A skin biopsy would provide information regarding the size of the involved vessels and the nature of the inflammatory infiltrate. The optimal time frame would be 24-48 hours after lesion onset. keywords: abdominal; addition; affected; age; american; anca; anti; antibodies; antibody; aorta; arteries; arteritis; artery; associated; association; basement; behcet; biopsies; biopsy; branches; c1q; cases; cell; changes; children; chronic; churg; classification; clinical; cogan; common; complex; coronary; correlation; course; criteria; cutaneous; cytoplasmic; deposition; diagnosis; differential; direct; disease; egpa; eosinophilic; erythema; erythematosus; extremities; factors; features; fever; fig; findings; following; form; frequent; gastrointestinal; gbm; genetic; giant; glomerular; glomerulonephritis; gpa; granulomatosis; greater; group; hcv; hemorrhage; histologic; hla; iga; igg; igm; iii; immune; immunofluorescence; important; infection; infiltrate; inflammation; inflammatory; involved; involvement; kawasaki; kidney; laboratory; large; lesions; leukocytoclastic; leukocytoclastic vasculitis; livedo; loss; lower; lung; lupus; lymphocytic; main; major; manifestations; medium; membrane; microscopic; mpa; mpo; necrosis; necrotizing; neuropathy; neutrophils; nodosa; nodules; non; older; organ; pain; palpable; pan; patients; peripheral; perivascular; phase; polyangiitis; polyarteritis; population; positive; pr3; presence; presentation; prognosis; pulmonary; purpura; rare; renal; respiratory; reticularis; review; rheumatoid; risk; sarcoidosis; secondary; serum; sized; skin; sle; small; specificity; spectrum; stage; strauss; studies; study; survival; symptoms; syndrome; systemic; systemic vasculitis; takayasu; tissue; tract; type; ulcers; urticarial; vascular; vasculitis; vessel; vessel vasculitis; walls; wegener; years cache: cord-0034758-vqeeaagp.txt plain text: cord-0034758-vqeeaagp.txt item: #125 of 251 id: cord-0034781-jsbca3xq author: Butnor, Kelly J. title: Collagen Vascular Diseases and Disorders of Connective Tissue date: 2008 words: 14083 flesch: 19 summary: Collagen vascular diseases are a diverse group of systemic inflammatory disorders thought to be immunologically mediated. Pleuropulmonary manifestations are a significant source of morbidity and mortality for patients with collagen vascular diseases. An estimated 1600 deaths result from pulmonary manifestations of collagen vascular disease each year in the United States. keywords: abnormalities; acute; affected; airway; alveolar; alveolitis; amyloidosis; aneurysms; antibodies; antiphospholipid; arterial; arthritis; arthritis pulmonary; associated; association; autoimmune; behcet; bilateral; biliary; biopsy; bowel; bronchial; bronchiectasis; bronchiolitis; cancer; cases; cells; changes; chapter; chest; chronic; cirrhosis; clinical; colitis; collagen; collagen vascular; common; complications; connective; connective tissue; course; crohn; cutis; danlos; dermatomyositis; diagnosis; diffuse; disease; disorders; dpm; ehlers; elastic; elasticum; endothelial; eosinophilic; erythematosus; fatal; features; fever; fibrosing; fibrosis; fig; findings; follicular; form; granulomatosis; hemorrhage; high; histologic; hypertension; idiopathic; incidence; infection; inflammation; inflammatory; injury; interstitial; interstitial lung; interstitial pneumonia; involvement; juvenile; laxa; lesions; limited; literature; lung; lung disease; lupus; lupus erythematosus; lymphocytic; lymphoid; lymphoma; major; manifestations; marfan; mixed; muscle; necrobiotic; nodular; nodules; nonspecific; nsip; obliterans; onset; organizing; pathologic; patients; pattern; pleural; pleuritis; pleuropulmonary; pneumonia; pneumonitis; pneumothorax; polychondritis; polymyositis; prevalence; primary; primary sjogren; prognosis; progressive; pseudoxanthoma; pulmonary; pulmonary disease; pulmonary fibrosis; pulmonary hemorrhage; pulmonary hypertension; pulmonary involvement; pulmonary manifestations; pulmonary rheumatoid; pulmonary vascular; rare; reported; respiratory; review; rheumatoid; rheumatoid arthritis; rheumatoid disease; rheumatoid lung; rheumatoid nodules; risk; sarcoidosis; scleroderma; sclerosis; series; severe; similar; sjogren; sle; spondylitis; spontaneous; stenosis; studies; study; survival; symptoms; syndrome; syndrome pulmonary; systemic; systemic lupus; systemic sclerosis; therapy; tissue; tissue disease; treatment; uip; ulcerative; upper; vascular; vascular disease; vasculitis; years cache: cord-0034781-jsbca3xq.txt plain text: cord-0034781-jsbca3xq.txt item: #126 of 251 id: cord-0035199-jwv0g2ey author: Ueda, Shiro title: Gold salts, D-penicillamine and allopurinol date: 2008 words: 10417 flesch: 36 summary: Gold salts have been used in the treatment of rheumatoid arthritis since 1927. Chrysotherapy is the second-line treatment of the disease. Before the introduction of orally administered gold compound, auranofin, parenterally administered gold salts, such as sodium aurothiomalate and gold thioglucose comprised chrysotherapy. keywords: acute; addition; adverse; allopurinol; antibodies; antibody; antigens; arthritis; arthritis patients; associated; association; auranofin; aurothiomalate; basement; biopsy; case; cells; changes; chrysotherapy; clinical; complex; complexes; complication; confirmed; day; dense; deposition; deposits; development; disease; dose; dr3; drug; drw3; dysfunction; effects; electron; epithelial; erythematosus; et al; failure; frequency; function; glomerular; glomerulonephritis; gold; gold nephropathy; gold salts; gold therapy; gout; granular; high; hla; human; hypersensitivity; hyperuricemia; igg; immune; induced; interstitial; introduction; lesions; like; lupus; membrane; membranous; mice; microscopy; months; myasthenia; necrosis; nephropathy; oral; oxypurinol; pathogenesis; patients; penicillamine; penicillamine therapy; plasma; positive; present; previous; progressive; proteinuria; rasburicase; reactions; renal; reported; rheumatoid; rheumatoid arthritis; risk; role; salts; sclerosis; serum; severe; skin; sodium; specimens; studies; study; successful; syndrome; systemic; therapy; time; toxicity; treatment; trial; tubular; type; use; vasculitis; wilson; withdrawal; xanthine cache: cord-0035199-jwv0g2ey.txt plain text: cord-0035199-jwv0g2ey.txt item: #127 of 251 id: cord-0035223-78r0rsio author: Jani, Meghna title: Management of the Rheumatoid Arthritis Patient with Interstitial Lung Disease date: 2017 words: 15260 flesch: 30 summary: The management of rheumatoid arthritis (RA) has changed dramatically over the past 15-20 years. With the introduction of novel therapies comes a wider choice in selecting the best treatment for the individual patient. Interstitial lung disease (ILD) is one of the most common respiratory manifestations in patients with RA. Serious respiratory adverse events (SRAEs) in the patient with RA on treatment for their joint disease may be due to induction of 'pneumonitis' or idiosyncratic adverse drug reactions. keywords: abatacept; active; acute; adalimumab; agents; analysis; anti; antirheumatic; arm; arthritis; associated; association; available; baseline; benefit; biologic; blind; case; certolizumab; clinical; combination; complications; concerns; cyclophosphamide; data; deaths; decisions; disease; dose; double; drug; early; effects; efficacy; etanercept; events; evidence; exacerbation; existing; experience; extension; factor; fibrosis; follow; function; glucocorticoids; group; hrct; human; idiopathic; iii; ild; improvement; inadequate; incidence; incident; infection; infliximab; inhibitors; injury; interstitial; interstitial lung; ipf; japanese; joint; leflunomide; likely; limited; literature; long; lung; lung disease; management; methotrexate; monotherapy; mortality; mtx; mycophenolate; nbdmards; necrosis; new; non; nsip; observational; observed; onset; outcomes; p13; patients; pfts; phase; pirfenidone; placebo; pneumonia; pneumonitis; possible; post; potential; pre; previous; progression; pulmonary; randomised; rcts; recent; receptor; reported; reports; respiratory; response; results; retrospective; review; rheumatoid; rheumatoid arthritis; risk; rituximab; safety; scleroderma; sclerosis; series; severe; severity; small; spontaneous; sraes; studies; study; survival; symptoms; systemic; table; therapies; therapy; tnfi; tocilizumab; tofacitinib; toxicity; treatment; trial; uip; use; weeks; year cache: cord-0035223-78r0rsio.txt plain text: cord-0035223-78r0rsio.txt item: #128 of 251 id: cord-0035681-0wyl2h62 author: Appanna, Vasu D. title: Dysbiosis, Probiotics, and Prebiotics: In Diseases and Health date: 2018 words: 14267 flesch: 43 summary: The disruption of a working microbiome is referred to as dysbiosis and is a condition where the fine balance between the microbial communities and the host is disturbed. It can cause various diseases such as cancer, irritable bowel syndrome, rheumatoid arthritis, acne, gastric ulcers, obesity and hypertension. Probiotics, prebiotics and synbiotics are potent therapeutic tools designed to rectify this situation. keywords: ability; abnormal; abnormalities; acid; activities; activity; age; ageing; ailments; air; akin; antibiotics; associated; bacteria; balance; bifidobacteria; biological; blood; body; box; brain; cancer; cause; cells; change; chemicals; cholesterol; clear; common; community; complications; conditions; constant; constituents; contribute; critical; decrease; diet; dietary; disease; disorders; disruption; diversity; dysbiosis; energy; environment; enzymes; essential; establishment; excellent; factors; family; fatty; fermented; fig; fine; foods; functions; good; growth; gut; gut microbiome; harmony; health; help; high; host; human; imbalance; immune; impact; important; increase; individuals; infants; instance; intake; intestinal; invisible; invisible organ; lactobacillus; landscape; like; low; lungs; major; manner; medications; members; metabolic; microbes; microbial; microbial balance; microbial communities; microbial ecosystem; microbial landscape; microbial population; microbiome; microorganisms; milk; mouth; natural; neurological; non; number; numerous; nutrients; nutritional; obesity; opportunistic; opportunistic microbes; oral; organ; organisms; partners; parts; patients; people; perturbation; population; presence; probiotics; products; proliferation; proper; proper microbial; reduction; remedy; residents; responsible; result; rich; rise; role; scfa; select; shift; signals; situation; skin; species; specific; spp; stomach; streptococcus; sugar; surprising; syndrome; system; tasks; therapy; trigger; uncontrolled; understanding; variety; way; wide; world cache: cord-0035681-0wyl2h62.txt plain text: cord-0035681-0wyl2h62.txt item: #129 of 251 id: cord-0036416-87cccwap author: Katsanos, Aristeidis H. title: Biomarker Development in Chronic Inflammatory Diseases date: 2017 words: 11285 flesch: 35 summary: Katsanos, Aristeidis, Kyriakidi, Karassa, Fotini B., Politis, Dimitrios, Skamnelos, Christodoulou, Katsanos, Konstantinos H. discuss the development of biomarkers for chronic inflammatory conditions. keywords: acpa; activation; active; activity; acute; analysis; anti; antibodies; antibody; antigen; ards; arthritis; asca; assay; assessment; autoantibodies; autoimmune; biological; biomarkers; biopsy; blood; bowel; calprotectin; cd patients; cell; cerebrospinal; changes; chronic; chronic inflammatory; clinical; colitis; common; complex; concentrations; conditions; correlate; course; crp; csf; cytokines; damage; detection; development; diagnosis; different; discovery; disease; disease activity; disorders; dsdna; early; elevated; elisa; enzyme; esr; evidence; factor; fecal; fibrosis; fluid; future; gastrointestinal; genetic; glycoprotein; hepatitis; high; higher; ibd; igg; il-6; immune; increase; inflammation; inflammatory; involvement; laboratory; levels; life; liver; low; lupus; major; manifestations; medicine; monitoring; mucosal; multiple; negative; neutrophil; new; normal; novel; organ; pathogenesis; patients; peripheral; phase; plasma; platelet; positive; potential; practice; predictive; presence; present; prognosis; promising; protein; psoriasis; rate; relapse; reliable; renal; response; results; rheumatoid; risk; role; sclerosis; sensitive; sensitivity; serological; serum; severity; skin; sle; specific; specificity; studies; study; systemic; table; target; test; therapeutic; therapy; tissue; titers; tnf; tract; treatment; urine; use; useful; value; vasculitis cache: cord-0036416-87cccwap.txt plain text: cord-0036416-87cccwap.txt item: #130 of 251 id: cord-0037182-w2tz1bdt author: Junker, Anna title: Selective and Dual Targeting of CCR2 and CCR5 Receptors: A Current Overview date: 2014 words: 13887 flesch: 43 summary: There is growing interest in CCR2 and CCR5 receptor antagonists for the treatment of inflammatory diseases. Maraviroc is the only FDA- and EMEA-approved drug that targets the CCR4 receptor. The CCR3 receptor has become a promising target in the therapy of atherosclerosis. keywords: 2d6; active; activity; affinity; amine; ammonium; antagonists; antiviral; approach; aromatic; arthritis; assay; atherosclerosis; atoms; basic; binding; bioavailability; candidate; carbon; cardiovascular; ccr2; ccr2 antagonists; ccr2 binding; ccr2 ligands; ccr5; ccr5 affinity; ccr5 receptor; cell; central; channel; chemokine; chemokine receptor; class; clinical; compounds; cxcr4; cyp; derivative; development; different; discovery; diseases; drug; dual; dual ccr2; effects; efficacy; fig; functional; fusion; glu291; group; herg; herg affinity; herg channel; high; high ccr2; hiv-1; homology; human; important; improved; infection; inflammation; inflammatory; inhibition; interaction; introduction; lead; ligands; linker; low; maraviroc; merck; methyl; model; modifications; moiety; molecule; monocytes; multiple; new; novel; optimization; oral; order; pharmacokinetic; pharmacophore; phenyl; piperidine; pocket; position; potent; potent ccr2; potential; profile; promising; properties; quaternary; receptor; receptor affinity; receptor antagonists; reduced; related; replacement; residues; resistance; rheumatoid; ring; role; sar; sect; selective; selectivity; series; site; small; structure; studies; substituent; substitution; synthesis; system; table; tak-220; tak-779; targeting; tertiary; therapeutic; treatment; trials; value; virus cache: cord-0037182-w2tz1bdt.txt plain text: cord-0037182-w2tz1bdt.txt item: #131 of 251 id: cord-0037486-qs7ztlor author: Matta, Bassem N. title: B-Cell Targeted Therapies in Autoimmune Cytopenias and Thrombosis date: 2013 words: 7854 flesch: 31 summary: B-cell depleting agents are used to treat autoimmune hematologic cytopenias such as ITP, Evans syndrome, cold and warm autoimmune hemolytic anemia, and thrombocytopenia. Since the advent of Rituximab and other compounds targeting B cells, a cornucopia of medical applications have been found for this family of compounds. keywords: acl; addition; adults; agents; aiha; anemia; antibodies; antibody; antiphospholipid; antiphospholipid syndrome; apl; aps; asherson; associated; autoimmune; barcellini; berentsen; bleeding; cases; cells; chronic; clinical; cold; corticosteroids; criteria; cytopenias; data; dexamethasone; diagnosis; disease; disorders; dose; effective; efficacy; et al; evans; exchange; factor; hemolytic; high; idiopathic; itp; line; long; low; lupus; lymphoma; management; manifestations; monoclonal; new; non; patients; plasma; platelet; primary; prospective; purpura; rate; recent; refractory; reported; reports; response; results; review; rituximab; safety; secondary; splenectomy; standard; stasi; studies; study; syndrome; systemic; therapeutic; therapies; therapy; thrombocytopenic; thrombocytopenic purpura; thrombotic; time; treatment; trial; ttp; use; warm; weeks; years; zecca; β2gpi cache: cord-0037486-qs7ztlor.txt plain text: cord-0037486-qs7ztlor.txt item: #132 of 251 id: cord-0037678-qo30oajs author: Lee, Eun Young title: Glucocorticoids (as an Etiologic Factor) date: 2014 words: 5243 flesch: 25 summary: Adrenocortical hormones were first prepared from the adrenal gland by Kendall in 1935. Hench et al. observed a miraculous effect of cortisone in a patient with severe rheumatoid arthritis 13 years later. Since then, glucocorticoids have been used as a first-line therapy for immune-mediated conditions or as an adjunctive therapy in many inflammatory, infectious, or malignant diseases. In 1957, the first case of GI-FHON was reported. keywords: acute; alendronate; association; autologous; avascular; bone; cases; cells; children; clinical; collapse; conditions; corticosteroid; decrease; development; dexamethasone; different; diseases; dose; early; effects; endothelial; erythematosus; expression; factor; femoral; femoral head; fhon; formation; glucocorticoids; head; high; higher; hip; human; imaging; incidence; increase; leukemia; long; low; lupus; lymphoblastic; magnetic; marrow; mechanisms; methylprednisolone; mri; new; nontraumatic; osteoblast; osteocytes; osteonecrosis; pain; patients; prevention; progression; prospective; rabbits; renal; resonance; results; risk; rst; signifi; sle; stage; studies; study; suppress; symptomatic; systemic; term; therapy; tissue; transplantation; treatment; underlying; use; years cache: cord-0037678-qo30oajs.txt plain text: cord-0037678-qo30oajs.txt item: #133 of 251 id: cord-0037759-eiyqwgu2 author: Bhavsar, Ishita title: Macrophage Inflammatory Protein-1 Alpha (MIP-1 alpha)/CCL3: As a Biomarker date: 2015 words: 7822 flesch: 33 summary: Macrophage inflammatory protein-1 alpha (MIP-1a/CCL3) is a chemotactic chemokine secreted by macrophages. It plays an important role in the pathogenesis of periodontitis, multiple myeloma, Sjögren syndrome, and rheumatoid arthritis. Biological fluids from patients with these diseases exhibit elevated levels of M IP-1A/CBL3. MIP/CCL3 protein may have diagnostic potential for the detection of several inflammatory diseases and conditions. keywords: accumulation; activation; activity; acute; aggressive; alpha; arthritis; bacterial; biological; biomarker; bone; ccl3; ccl4; ccr1; ccr5; cells; chemokines; chronic; concentrations; cytokines; destruction; diagnostic; disease; elevated; epithelial; et al; exhibit; expression; factors; fibroblasts; fig; findings; fluid; functions; gingival; healthy; hematopoietic; higher; hiv; host; human; immune; implant; important; increased; infection; inflammation; inflammatory; leukocytes; levels; loss; lps; lymphocytes; macrophage; marrow; mediators; migration; mip-1alpha; mip-1α; multiple; myeloma; oral; osteoclast; pathogenesis; patients; periodontal; periodontitis; plasma; potential; process; production; protein; protein-1; rantes; receptors; recruiting; recruitment; resorption; response; rheumatoid; role; salivary; sarcoidosis; secrete; serum; site; stem; strong; studies; study; subjects; syndrome; tissue; tooth; tumor; virus; wound cache: cord-0037759-eiyqwgu2.txt plain text: cord-0037759-eiyqwgu2.txt item: #134 of 251 id: cord-0042079-2cttcck1 author: Hjelmevik, T. O. title: Infliximab Treatment of Rheumatoid Arthritis Patients Simultaneously Increases TNF‐α Protein Levels and Reduces mRNA Expression in the Blood date: 2008 words: 16945 flesch: 44 summary: Infliximab treatment of rheumatoid arthritis patients increases TNF-α protein levels and reduces mRNA expression in the blood. Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. In Italy, incidence is lower, with the exception for Sardinia, where it is higher. keywords: acid; activation; activity; addition; adenosine; ag85a; aim; allergen; allergic; analysis; animals; antibodies; antibody; antigens; antiviral; applied; assays; associated; association; asthma; bacteria; binding; blood; cancer; capacity; carcinoma; cd4; cd8; cells; cellular; cla; clinical; coli; complement; concentration; conclusion; control; corresponding; cytokine; cytometry; cytotoxicity; data; database; dcs; def; dendritic; dependent; der; development; differences; different; disease; dna; domain; donors; e.g.; effects; epitopes; exon; expression; factor; ficolin; findings; flora; flow; gene; group; growth; gut; hbsag; healthy; high; higher; hla; human; ifn; iga1; igg; igm; il-12; immune; immunity; immunotherapy; important; increase; individuals; induction; infection; inflammation; inflammatory; information; innate; involved; lab; lactobacillus; large; lectin; levels; like; line; low; lower; lymph; macrophages; major; malaria; markers; masp-2; maturation; mbl; mbp; methods; mhc; mice; microarrays; model; molecular; molecules; monocytes; mononuclear; mrna; mucosa; negative; nephropathy; nk cells; nodes; normal; novel; opri; oral; ospe; pathogenesis; pathway; patients; pbmcs; peptide; peripheral; phenotype; positive; potential; presence; present; probes; production; proliferation; protease; protein; proteome; pylori; qbc; receptor; recognition; recombinant; release; response; results; role; samples; sassari; sentinel; sequence; sera; serum; significant; similar; single; site; skin; species; specific; stimulation; stockholm; strains; strong; studies; study; subsequent; surface; surgery; survival; svegf; svegfr1; system; t cells; target; th1; th2; time; tlr; tnf; tnf‐α; treatment; tumour; type; use; vaccine; virus; vitamin; vitro; vivo; weeks; þ t cache: cord-0042079-2cttcck1.txt plain text: cord-0042079-2cttcck1.txt item: #135 of 251 id: cord-0042121-10vhc3dn author: Astrinidou‐Vakaloudi, A. title: Autoantibodies in Patients with Rheumatoid Arthritis date: 2008 words: 16931 flesch: 44 summary: Autoantibodies are useful diagnostic serological markers in rheumatoid arthritis. They are often and show higher specificity for RA. Multiple sclerosis (MS) is characterized by recurrent inflammation involving macrophages and their inflammatory mediators. In Italy, incidence is lower, with the exception for Sardinia, where it is higher. keywords: acid; activation; activity; addition; adenosine; ag85a; aim; allergen; allergic; analysis; animals; antibodies; antibody; antigens; antiviral; applied; assays; associated; association; asthma; bacteria; binding; blood; cancer; capacity; carcinoma; cd4; cd8; cells; cellular; cla; clinical; coli; complement; concentration; conclusion; control; corresponding; cytokine; cytometry; cytotoxicity; data; database; dcs; def; dendritic; dependent; der; development; differences; different; disease; dna; domain; donors; e.g.; effects; epitopes; exon; expression; factor; ficolin; findings; flora; flow; gene; group; growth; gut; hbsag; healthy; high; higher; hla; human; ifn; iga1; igg; igm; il-12; immune; immunity; immunotherapy; important; increase; individuals; induction; infection; inflammation; inflammatory; information; innate; involved; lab; lactobacillus; large; lectin; levels; like; line; low; lower; lymph; macrophages; major; malaria; markers; masp-2; maturation; mbl; mbp; methods; mhc; mice; microarrays; model; molecular; molecules; monocytes; mononuclear; mrna; mucosa; negative; nephropathy; nk cells; nodes; normal; novel; opri; oral; ospe; pathogenesis; pathway; patients; pbmcs; peptide; period; peripheral; phenotype; positive; potential; presence; present; probes; production; proliferation; protease; protein; proteome; pylori; qbc; receptor; recognition; recombinant; release; response; results; role; samples; sassari; sentinel; sequence; sera; serum; significant; single; site; skin; species; specific; stimulation; stockholm; strains; strong; studies; study; subsequent; surface; surgery; survival; svegf; svegfr1; system; t cells; target; th1; th2; time; tlr; tnf; treatment; tumour; type; use; vaccine; virus; vitamin; vitro; vivo; weeks; þ t cache: cord-0042121-10vhc3dn.txt plain text: cord-0042121-10vhc3dn.txt item: #136 of 251 id: cord-0042126-1tbk96e1 author: Bjoernhart, B. title: Plasma TNF‐Binding Capacity and Soluble TNF Receptors in Patients with Juvenile Idiopathic Arthritis date: 2008 words: 16916 flesch: 44 summary: TNFR levels in JIA patients were slightly reduced, but the capacity to bind TNF was increased in plasma samples. MS from Stockholm was associated with higher levels of LXR-a compared to MS from Sassari, Sardinia and Stockholm. keywords: acid; activation; activity; addition; adenosine; ag85a; aim; allergen; allergic; analysis; animals; antibodies; antibody; antigens; antiviral; applied; assays; associated; association; asthma; bacteria; binding; blood; cancer; capacity; carcinoma; cd4; cd8; cells; cellular; cla; clinical; coli; complement; concentration; conclusion; contrast; control; corresponding; cytokine; cytometry; cytotoxicity; data; database; dcs; def; dendritic; dependent; der; development; differences; different; disease; dna; domain; donors; e.g.; effects; elisa; epitopes; exon; expression; factor; ficolin; findings; flora; flow; gene; group; growth; gut; hbsag; healthy; high; higher; hla; human; ifn; iga1; igg; igm; il-12; immune; immunity; immunotherapy; important; increase; individuals; induction; infection; inflammation; inflammatory; information; innate; involved; lab; lactobacillus; large; lectin; levels; like; line; low; lower; lymph; macrophages; major; malaria; markers; masp-2; maturation; mbl; mbp; methods; mhc; mice; microarrays; model; molecular; molecules; monocytes; mononuclear; mrna; mucosa; negative; nephropathy; nk cells; nodes; normal; novel; opri; oral; ospe; pathogenesis; pathway; patients; pbmcs; peptide; peripheral; phenotype; plasma; positive; potential; presence; present; probes; production; proliferation; protease; protein; proteome; pylori; qbc; receptor; recognition; recombinant; release; response; results; role; samples; sassari; sentinel; sera; serum; significant; single; site; skin; species; specific; stimulation; stockholm; strains; strong; studies; study; subsequent; surface; surgery; survival; svegf; svegfr1; system; t cells; target; th1; th2; time; tlr; tnf; treatment; tumour; type; use; vaccine; virus; vitamin; vitro; vivo; weeks; þ t cache: cord-0042126-1tbk96e1.txt plain text: cord-0042126-1tbk96e1.txt item: #137 of 251 id: cord-0042147-r04y1j22 author: Hedegaard, C. J. title: The Role of Immune Complexes Consisting of Myelin Basic Protein (MBP), Anti‐MBP Antibodies and Complement in Promoting CD4(+) T‐cell Responses to MBP in Health and Multiple Sclerosis date: 2008 words: 16954 flesch: 44 summary: Multiple sclerosis (MS) is an autoimmune condition characterized by degeneration of nerve fibre myelin sheets. Myelin basic protein (MBP) is a candidate autoantigen that is a predictor of MS. MBP promotes the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients. keywords: acid; activation; activity; addition; adenosine; ag85a; aim; allergen; allergic; analysis; animals; antibodies; antibody; antigens; antiviral; applied; assays; associated; association; asthma; b cells; bacteria; binding; blood; cancer; capacity; carcinoma; cd4; cd8; cells; cellular; cla; clinical; coli; complement; complexes; concentration; conclusion; control; cytokine; cytometry; cytotoxicity; data; database; dcs; dendritic; dependent; der; development; differences; different; disease; dna; domain; donors; e.g.; effects; epitopes; exon; expression; factor; ficolin; findings; flora; flow; gene; group; growth; gut; hbsag; healthy; high; higher; hla; human; ics; ifn; iga1; igg; igm; il-12; immune; immunity; immunotherapy; important; increase; individuals; induction; infection; inflammation; inflammatory; information; innate; involved; lab; lactobacillus; large; lectin; levels; like; line; low; lower; lymph; macrophages; major; malaria; markers; masp-2; maturation; mbl; mbp; methods; mhc; mice; microarrays; model; molecular; molecules; monocytes; mononuclear; mrna; mucosa; multiple; negative; nephropathy; nk cells; nodes; normal; novel; opri; oral; ospe; pathogenesis; pathway; patients; pbmcs; peptides; peripheral; phenotype; positive; potential; presence; present; probes; production; proliferation; protease; protein; proteome; pylori; qbc; receptor; recognition; recombinant; release; response; results; role; samples; sassari; sentinel; sera; serum; significant; single; site; skin; species; specific; stimulation; stockholm; strains; strong; studies; study; subsequent; surface; surgery; survival; svegf; svegfr1; system; t cells; target; th1; th2; time; tnf; treatment; tumour; type; use; vaccine; virus; vitamin; vitro; vivo; weeks; þ t cache: cord-0042147-r04y1j22.txt plain text: cord-0042147-r04y1j22.txt item: #138 of 251 id: cord-0045298-fawll2v7 author: Fletcher, Ashley title: Oral Complementary Medicine Use among People with Inflammatory Arthritis: An Australian Rheumatology Association Database Analysis date: 2020 words: 4167 flesch: 47 summary: Oral complementary medicine (CM) use is common among Australians with inflammatory arthritis. Its use is greater among women and those with tertiary education. The most common CMs were fish oils (N = 1,489 users) followed by glucosamine ( N = 605). Both declined in use between 2006 and 2016. keywords: acids; alternative; analysis; arad; arthritis; association; australian; baseline; characteristics; cm use; cms; common; complementary; current; data; database; demographic; disease; fatty; fish; glucosamine; health; herbs; higher; inflammatory; jia; life; lower; medicine; national; oil; oral; overall; pain; participants; patients; people; population; prevalence; psa; quality; questionnaire; results; review; rheumatoid; rheumatology; self; study; supplements; survey; systematic; tertiary; time; trend; use cache: cord-0045298-fawll2v7.txt plain text: cord-0045298-fawll2v7.txt item: #139 of 251 id: cord-0046741-szb45jm2 author: Reza Khorramizadeh, M. title: Animal models for human disease date: 2020 words: 11619 flesch: 42 summary: Reza Khorramizadeh, M. Saadat and Farshid discuss animal models for human disease. They explain collagen-induced arthritis as an animal model that reflects a characteristic feature of RA patients and EAE as an experimental model for MS. keywords: activation; activity; addition; adjuvant; agents; animal; animal models; antibodies; antibody; antigen; arthritis; autoimmune; axonal; base; blood; bone; brain; cartilage; cd4; cd8; cells; cfa; characteristic; cia; cii; class; clinical; cns; collagen; common; complete; complex; components; conditions; cord; course; csf; cytokines; damage; day; demyelination; destruction; development; different; disease; disorder; dmards; drugs; eae; early; effect; effective; efficacy; encephalomyelitis; enzyme; et al; experimental; experimental models; expression; factors; fluid; formation; function; genetic; high; histocompatibility; hla; human; ifn; il-6; immune; important; individuals; induced; induction; inflamed; inflammation; inflammatory; injection; joint; lesions; like; long; lymphocytes; macrophages; main; major; mechanisms; methotrexate; mhc; mice; models; molecules; monoclonal; mouse; ms patients; multiple; myelin; new; number; onset; pain; pannus; pathogenesis; patients; pbs; pfa; phase; potential; present; progressive; protein; rats; receptor; regulatory; research; response; results; rheumatoid; rheumatoid arthritis; risk; rna; role; sclerosis; severity; similar; species; specific; spinal; spontaneous; studies; study; surface; symptoms; synovial; synovium; system; t cells; tail; target; telomerase; term; therapeutic; therapy; time; tissue; tnf; treatment; trials; type; use; years cache: cord-0046741-szb45jm2.txt plain text: cord-0046741-szb45jm2.txt item: #140 of 251 id: cord-0048130-8f463wz0 author: Viedma-Poyatos, Álvaro title: Type III intermediate filaments as targets and effectors of electrophiles and oxidants date: 2020 words: 12710 flesch: 29 summary: Viedma-Poyatos, Álvaro, Pajares, María A., Pérez-Sala, Dolores and their colleagues discuss the role of type III intermediate filaments in cell mechanics, signaling and homeostasis. Vimentin, desmin, peripherin and GFAP are important components of the cytoplasmic cytoskeleton and are expressed in specific cell types. Their cysteine residue is a hot spot for oxidants and electrophiles. keywords: 15d; acidic; acidic protein; acrolein; actin; activation; activity; addition; adducts; aggregates; aging; alexander; alterations; alzheimer; analysis; antioxidant; assembly; astrocytes; brain; bulky; c328; cancer; carbonyl; carbonylation; cells; cellular; certain; characterization; close; conditions; consequences; conserved; control; cortex; critical; cypg; cysteine; cysteine residue; cytoskeletal; damage; deficient; degradation; dependent; desmin; diamide; different; disease; disruption; disulfide; diverse; dynamics; early; effects; electrophilic; elongation; endothelial; enzymatic; evidence; experimental; exposure; expression; extent; fibrillary; fibroblasts; fig; filament; formation; free; function; gfap; glial; glutathionylation; high; hne; human; identification; ifs; iii; impact; important; increase; interactions; intermediate; intermediate filament; interplay; key; levels; like; lipids; lipoxidation; loss; lung; major; mechanisms; mice; migration; mitosis; models; modifications; modified; moieties; multiple; muscle; mutant; mutations; network; neuronal; nitrated; nitric; nitrosation; non; nuclear; nucleophilic; numerous; organization; oxidants; oxidative; oxidative modifications; oxidative stress; oxide; particular; pathophysiological; patients; peripherin; pgj; phosphorylation; position; presence; processes; products; protein; proteomic; ptms; radic; reactive; redox; ref; regulation; related; residues; response; reversible; role; senescent; signaling; site; small; soluble; species; specific; stress; structure; studies; syndrome; system; target; tetramer; thiol; treatment; type; tyrosine; use; vimentin; vitro; wfa; wild; withaferin cache: cord-0048130-8f463wz0.txt plain text: cord-0048130-8f463wz0.txt item: #141 of 251 id: cord-0048681-wp6xmaqe author: Kubota, Kazuo title: Basic Science of PET Imaging for Inflammatory Diseases date: 2019 words: 15826 flesch: 33 summary: FDG-PET/CT has recently emerged as a useful tool for the evaluation of inflammatory diseases. The imaging is based on active glucose utilization by inflammatory tissue. Inflammatory cells and cancer cells seem to share the same molecular mechanism of elevated glucose metabolism. keywords: 18f; accumulation; activation; active; activity; acute; addition; alzheimer; amyloid; analysis; animal; area; arthritis; astrocytes; atherosclerotic; benzodiazepine; binding; biomarker; bone; brain; cancer; carotid; cells; cellular; changes; chronic; citrate; clinical; cns; colony; comparison; control; correlated; correlation; csf1r; cytokines; damage; day; dependent; detection; development; differences; differentiation; disease; disorders; distinct; distribution; drugs; eae; early; effects; elevated; emission; evaluation; evidence; experimental; expression; f]fedac; factor; fdg; fdg uptake; fibroblasts; fibrosis; fig; focal; formation; functions; glial; glucose; growth; hif-1α; high; higher; human; hypoxia; imaging; immune; immunohistochemical; important; increase; induction; infected; infectious; infiltration; inflammation; inflammatory; injection; injury; ischemia; kda; lesions; level; like; limited; liver; lps; lung; macrophages; major; mechanism; metabolism; mice; microglia; model; molecular; monitoring; monocytes; mouse; mrna; multiple; nafld; network; neurodegenerative; neuroinflammation; neuronal; neurons; neutrophils; new; non; novel; number; observed; p2x7; parkinson; pathological; pathologies; patients; peripheral; pet; pet imaging; phenotypes; plaques; positive; positron; potential; preclinical; probucol; production; progression; protein; quantitative; radioactivity; radioligand; rats; receptor; regions; related; response; responsible; results; role; sclerosis; small; specific; spinal; studies; study; surface; system; targeting; targets; tau; therapeutic; therapy; tissue; tomography; tool; tracer; translocator; transporter; treatment; tspo; tspo expression; tspo imaging; tspo pet; tumor; type; uptake; useful; vascular; vitro; vivo; vulnerable cache: cord-0048681-wp6xmaqe.txt plain text: cord-0048681-wp6xmaqe.txt item: #142 of 251 id: cord-0048700-cgg4u9lv author: Kirpotina, Liliya N. title: Therapeutic Effects of Tryptanthrin and Tryptanthrin-6-Oxime in Models of Rheumatoid Arthritis date: 2020 words: 9137 flesch: 38 summary: Rheumatoid arthritis is an autoimmune disease that involves inflammation and progressive damage to distal joints. New therapeutic approaches should be developed to prevent inflammation, immune system dysregulation, and bone destruction associated with this disease. Natural products have been shown to exhibit potential for treatment of inflammatory diseases. keywords: ache; activity; affinity; analysis; anti; antibody; arthritis; binding; bone; caia; cartilage; cells; cia; cia mice; cii; clinical; collagen; compounds; concentrations; control; csf; cultured; cytokines; daily; damage; day; days; derivatives; destruction; development; dmso; drug; effective; effects; elisa; erosion; et al; expression; factor; fbs; figure; fls; formation; human; i.p; il-1b; il-6; immune; infiltration; inflammation; inflammatory; inhibited; inhibitor; injection; iq-1s; jnk; jnk1; jnk3; joint; jun; kinase; levels; like; loss; macrophages; mapping; medium; mice; model; monocytic; mouse; new; novel; pharmacophore; pharmmapper; potential; production; properties; protein; rankl; rheumatoid; role; saline; scale; schepetkin; schepetkin et; score; secretion; serum; severe; signaling; significant; sp600125; specific; studies; surface; sw982; swelling; synovial; table; targets; terminal; test; therapeutic; tissue; treatment; tryp; tryptanthrin; usa; vivo cache: cord-0048700-cgg4u9lv.txt plain text: cord-0048700-cgg4u9lv.txt item: #143 of 251 id: cord-0049215-l46b5d2f author: Freites-Núñez, Dalifer title: Efficacy, safety and cost-effectiveness of a web-based platform delivering the results of a biomarker-based predictive model of biotherapy response for rheumatoid arthritis patients: a protocol for a randomized multicenter single-blind active controlled clinical trial (PREDIRA) date: 2020 words: 9320 flesch: 39 summary: Rheumatoid arthritis (RA) is one of the leading chronic inflammatory rheumatism. First-line therapy with synthetic disease-modifying antirheumatic drugs (sDMARD) is insufficiently effective in 40% of cases and patients are treated with biotherapies. The increased use of these drugs each year is becoming a public health issue with considerable economic burden. The study is a prospective, phase III, controlled, multicenter, and randomized, single-blind (patient) clinical trial, including RA patients with a previous failure to anti-TNF therapies. The main objective is the analysis of the clinical and pharmacoeconomic impact after 6 months of treatment. keywords: abatacept; access; activity; adalimumab; addition; analysis; anti; arm; arms; arthritis; arthritis patients; available; average; baseline; bdmards; biobank; biological; biomarkers; biotherapies; biotherapy; blind; blood; care; case; center; clinical; consent; control; control arm; cost; criteria; current; das28; data; database; different; disease; drugs; effectiveness; eular; follow; following; frame; good; group; health; impact; inclusion; information; informed; intervention; investigator; life; management; mean; measures; medical; medication; models; months; number; objectives; outcome; patients; practice; predictive; prescription; primary; profile; proteomic; protocol; randomized; ratio; recommendations; research; response; responsible; results; rheumatoid; rheumatoid arthritis; rheumatologist; rituximab; samples; secondary; sensitivity; sinnotest; software; spanish; strategies; study; study arm; subjects; therapeutic; time; treatment; trial; use; usual; utility; variables; visit; work cache: cord-0049215-l46b5d2f.txt plain text: cord-0049215-l46b5d2f.txt item: #144 of 251 id: cord-0054340-tlg21uma author: Mong, Nikolett title: Largely Accelerated Arterial Aging in Rheumatoid Arthritis Is Associated With Inflammatory Activity and Smoking in the Early Stage of the Disease date: 2020 words: 5661 flesch: 36 summary: Rheumatoid arthritis (RA) patients have a shorter life expectancy than the general population due to cardiovascular comorbidities. Arterial aging is faster in RA patients than in control subjects. Inflammation, previous cardiovascular events, and smoking are additional contributing factors to the intensified coronary atherosclerosis progression. keywords: accelerated; activity; additional; age; aging; analysis; anti; artage_dif; arterial; arterial age; artery; arthritis; article; atherosclerosis; authors; calcification; calcium; cardiovascular; cardiovascular disease; cardiovascular risk; ccs; control; coronary; crp; data; diabetes; difference; disease; distribution; duration; effect; estimate; et al; events; factors; figure; follow; gender-; heart; higher; infarction; inflammation; inflammatory; median; mesa; myocardial; nagy; observed; panel; participants; patients; peptide; population; previous; process; progression; ra patients; race; rate; rheumatoid; rheumatoid arthritis; right; risk; score; shows; significant; smokers; smoking; statistical; study; subjects; therapy; time; treatment; value; years cache: cord-0054340-tlg21uma.txt plain text: cord-0054340-tlg21uma.txt item: #145 of 251 id: cord-0055042-a4zeifia author: Surabhi, Surabhi title: The Role of NLRP3 Inflammasome in Pneumococcal Infections date: 2020 words: 4656 flesch: 25 summary: Inflammasomes are innate immune sensors that regulate caspase-1 mediated inflammation in response to environmental, host- and pathogen-derived factors. Inflammasome activation is implicated in autoimmune diseases such as rheumatoid arthritis, inflammatory bowel disease, and diabetes. In contrast, NLRP3 inflammaesome is an important defense mechanism against microbial infections. Pneumococcal infections are a leading cause of community-acquired pneumonia worldwide. keywords: activation; anakinra; arthritis; asc; atp; authors; autoimmune; bacterial; caps; caspase-1; cells; clearance; clinical; colonization; contrast; crucial; dependent; diabetes; diseases; domain; efflux; excessive; factors; figure; gene; group; gsdmd; host; human; il-1b; immune; infections; inflammasome; inflammation; inflammatory; innate; lysosomal; macrophages; mechanisms; membrane; mice; neutrophil; nlrp3; nlrp3 inflammasome; non; pathogen; patients; ply; pneumococcal; pneumoniae; priming; procaspase-1; processes; processing; production; protein; pyroptosis; receptors; release; reported; respiratory; responses; result; rheumatoid; rna; role; secretion; serotypes; signaling; step; stimuli; streptococcus; studies; study; subsequent; syndrome; terminal; tract; treatment; type cache: cord-0055042-a4zeifia.txt plain text: cord-0055042-a4zeifia.txt item: #146 of 251 id: cord-0061257-so4j6cms author: Hosseinikhah, Seyedeh Maryam title: Nanomaterials for the Diagnosis and Treatment of Inflammatory Arthritis date: 2021 words: 10558 flesch: 31 summary: Nanomaterials have received increasing attention due to their unique chemical and physical properties for the treatment of rheumatoid arthritis. Inflammatory arthritis is an autoimmune heterogenous group of joint disorders associated with pain, stiffness, bone erosion, synovial hyperplasia, and progressive joint destruction. keywords: ability; acid; activities; activity; agents; analysis; anti; antibodies; applications; approach; aqueous; arthritis; associated; authors; biocompatibility; blood; body; bone; cancer; cartilage; cationic; ccp; cells; characterization; circulation; clinical; common; conjugated; cur; damage; delivery; detection; development; dex; diagnosis; different; disease; disorders; dose; drug; drug delivery; early; effective; effects; efficacy; encapsulation; enhance; et al; evaluation; expression; factor; figure; film; gel; gold; high; higher; human; imaging; immune; improved; increase; inflamed; inflammation; inflammatory; inflammatory arthritis; injection; iron; joints; like; lipid; liposomes; loaded; loading; low; macrophages; magnetic; metal; methods; mice; micelles; mnps; model; mri; mtx; nanocarriers; nanomaterials; nanomedicine; nanoparticles; nanostructures; new; niosomal; niosomes; nir; nonionic; novel; nps; oxide; pain; patients; peg; physical; plga; polymeric; polymers; potential; prepared; progress; properties; rats; recent; reduced; release; resonance; results; retention; review; rheumatoid; rheumatoid arthritis; role; significant; silver; sirna; sites; size; slns; solubility; spions; study; suitable; superparamagnetic; surface; surfactants; synovial; synthesis; systems; targeted; targeting; techniques; tfc; therapeutic; therapy; time; tissue; tnf; toxicity; treatment; use; vesicles; vivo cache: cord-0061257-so4j6cms.txt plain text: cord-0061257-so4j6cms.txt item: #147 of 251 id: cord-0063314-txvr42cu author: Shipa, Muhammad R title: O07 The increase in erythrocyte mean corpuscular volume by methotrexate is potentiated by hydroxychloroquine and is an early indicator of clinical response in rheumatoid arthritis date: 2021 words: 1696 flesch: 40 summary: Methotrexate increases erythrocyte mean corpuscular volume (MCV). MCV is an early indicator of clinical response in rheumatoid arthritis. The combination of methotrexate with hydroxychloroquine and hydroxy chloroquine is the most effective treatment for RA. keywords: aes; arthritis; auroc; class; clinical; cohort; difference; disease; early; hydroxychloroquine; increase; learning; machine; mcv; mean; methods; methotrexate; model; months; patients; predictors; responders; response; rheumatoid; significant; treatment cache: cord-0063314-txvr42cu.txt plain text: cord-0063314-txvr42cu.txt item: #148 of 251 id: cord-0065630-6aztp98i author: Boutet, Marie-Astrid title: Circulating and Synovial Pentraxin-3 (PTX3) Expression Levels Correlate With Rheumatoid Arthritis Severity and Tissue Infiltration Independently of Conventional Treatments Response date: 2021 words: 6110 flesch: 28 summary: Praxin-3 (PTX3) expression is a reliable marker of rheumatoid arthritis (RA) activity and predicts a high degree of structural damages at 12-months. High synovial and peripheral blood levels of PTX3 are associated with chronic inflammation characteristic of RA. keywords: activity; acute; addition; analysis; anti; arthritis; association; baseline; blood; bone; cd68; cells; clinical; cohort; correlation; criteria; crp; damage; das28; data; diffuse; disease; dmards; donors; early; endothelial; example; expression; factor; fibroblasts; figure; following; gene; global; groups; healthy; higher; immune; infiltration; inflammation; inflammatory; influence; joint; levels; local; long; lympho; macrophages; module; months; myeloid; pathotype; patients; pauci; pentraxin; plasma; positive; post; presence; production; protein; ptx3; ptx3 expression; ra patients; relationship; response; results; rheumatoid; rna; samples; score; seq; serum; severity; status; structures; study; supplementary; synovial; synovium; systemic; tissue; transcript; treatment; usa cache: cord-0065630-6aztp98i.txt plain text: cord-0065630-6aztp98i.txt item: #149 of 251 id: cord-0065950-wxmnx7or author: Wang, Zunlian title: Comparison of the efficacy and safety indicators of DMARDs for rheumatoid arthritis: A network meta-analysis date: 2021 words: 3465 flesch: 36 summary: Tocilizumab and Sarilumab are the best antirheumatic drugs for rheumatoid arthritis according to a network meta-analysis. The prevalence of RA ranges from 0.4% to 1.3% and is associated with gender and region of residence. keywords: .05; acr20; adalimumab; adverse; agents; american; analysis; arthritis; baricitinib; biological; clinical; college; criteria; data; difference; disease; drugs; efficacy; evaluation; factor; il-6; incidence; inflammatory; literature; meta; necrosis; network; patients; phase; randomized; ranked; reactions; response; results; rheumatoid; rheumatoid arthritis; rheumatology; safety; sarilumab; significant; sirukumab; studies; study; terms; tnf; tocilizumab; treatment; trials cache: cord-0065950-wxmnx7or.txt plain text: cord-0065950-wxmnx7or.txt item: #150 of 251 id: cord-0065962-lg0lsfbz author: Dessie, Gashaw title: Effect of Leptin on Chronic Inflammatory Disorders: Insights to Therapeutic Target to Prevent Further Cardiovascular Complication date: 2021 words: 8423 flesch: 34 summary: The review mainly assesses the mechanism of leptin on the pathogenesis and further cardiovascular risk complication of chronic inflammatory disorders. Therapeutic target of leptin regarding its pro-inflammatory effect and dysregulated sympathetic nervous system activity may prevent further cardiovascular complication. keywords: activation; activity; addition; adipokines; adipose; aldosterone; anti; arthritis; association; atherosclerosis; autoimmune; biological; blood; cardiovascular; cells; chronic; complication; contrast; coronary; cvd; cytokines; development; diabetes; disease; disorders; effect; elevated; elevation; endothelial; energy; erythematosus; expression; factor; fat; figure; heart; hyperleptinemia; hypertension; ibd; il-6; immune; increase; inflammation; inflammatory; inflammatory cytokines; insulin; jak; leptin; level; lupus; macrophage; mellitus; metabolic; mets; mice; nervous; obese; obesity; pathogenesis; pathway; patients; perivascular; physiological; pressure; pro; psoriasis; receptor; release; resistance; response; review; rheumatoid; risk; role; secretion; serum; signaling; sle; stat3; studies; study; sympathetic; synthesis; system; systemic; th17; therapeutic; therapy; tissue; tnf; turn; type cache: cord-0065962-lg0lsfbz.txt plain text: cord-0065962-lg0lsfbz.txt item: #151 of 251 id: cord-0066109-g7ncbf9p author: Bogunia-Kubik, Katarzyna title: Disease Differentiation and Monitoring of Anti-TNF Treatment in Rheumatoid Arthritis and Spondyloarthropathies date: 2021 words: 7884 flesch: 43 summary: Bogunia-Kubik, Katarzyna, Wojtowicz, Swierkot, Jerzy, Mielko, Karolina Anna, Qasem, Badr, Wielińska, Renata, Pruss, Łukasz, Młynarz, Piotr are the authors of the study. They studied the metabolomics of rheumatoid arthritis, ankylosing spondylitis (AS), and psoriatic arthritis (PsA). keywords: acids; activity; amino; analysis; anova; anti; approach; arthritis; assessment; associated; average; axial; basdai; biological; changes; circle; comparison; compounds; creatine; criteria; das28; data; differences; different; disease; ethanol; female; figure; glutamine; glycol; green; groups; high; human; important; initialization; interquartile; levels; line; metabolism; metabolites; metabolomics; monitoring; months; multivariate; neutral; nmr; patients; pls; point; positive; present; profiles; progression; propylene; psa; psoriatic; quartile; ra patients; range; red; relative; resonance; response; results; rheumatoid; samples; serum; significant; spondyloarthritis; statistical; studies; study; table; test; therapy; time; tnf; tnf treatment; tnfi; treatment; trend; univariate; value; vip; vs.; yellow cache: cord-0066109-g7ncbf9p.txt plain text: cord-0066109-g7ncbf9p.txt item: #152 of 251 id: cord-0066404-19n62hi1 author: Lambrecht, Antonia title: Quality of a Supporting Mobile App for Rheumatic Patients: Patient-Based Assessment Using the User Version of the Mobile Application Scale (uMARS) date: 2021 words: 3675 flesch: 39 summary: The study looked at the quality of the self-management app Rheuma Auszeit for rheumatoid arthritis, psoriatic arthritis and spondyloarthritis in German patients. It found that it was well-accepted by German patients suffering from these conditions. The study underlines the potential and feasibility of therapeutic digital solutions in rheumaticology. keywords: activity; aesthetics; analysis; app; apps; arthritis; association; auszeit; characteristics; clinical; disease; ehealth; engagement; evaluation; functionality; german; individual; information; iqr; items; literacy; lower; management; median; mobile; older; paper; patients; physician; quality; rating; results; rheuma; rheumatic; rheumatology; rho; scale; score; self; study; subdomain; subjective; survey; total; umars; usage; user; variables; version cache: cord-0066404-19n62hi1.txt plain text: cord-0066404-19n62hi1.txt item: #153 of 251 id: cord-0066794-iw0rjwtd author: Dow, Coad Thomas title: Warm, Sweetened Milk at the Twilight of Immunity - Alzheimer’s Disease - Inflammaging, Insulin Resistance, M. paratuberculosis and Immunosenescence date: 2021 words: 6492 flesch: 25 summary: Mycobacterium avium paratuberculosis (MAP) is a precipitant of Alzheimer's disease (AD). Autophagy is the cellular housekeeping process that manages protein quality control and recycling, cellular metabolism, and pathogen elimination. MAP is a zoonotic mycobacterial infection that causes fatal enteritis in ruminants. India has extensively studied the human bio-load of MAP. keywords: accumulation; age; agents; aging; alzheimer; amyloid; analysis; animals; anti; antibiotic; antimicrobial; article; association; autoimmune; autophagy; avium; bbb; bcg; benefit; blood; brain; cellular; clinical; cns; cognitive; crohn; detection; development; diabetes; disease; drug; effects; enteric; evidence; factor; food; function; gut; human; immune; immunosenescence; individuals; infected; infection; inflammaging; inflammation; inflammatory; inhibition; insulin; intracellular; intranasal; leprosy; load; map; metabolism; metabolites; microbial; microbiome; milk; molecular; mtor; multiple; mycobacterium; mycobacterium avium; neurodegenerative; non; paratuberculosis; parkinson; pathogenic; patients; pcr; peptide; population; positive; potential; products; protein; rapamycin; related; resistance; response; rifampin; risk; role; sclerosis; signaling; sirt1; studies; study; subsp; subspecies; syndrome; system; target; tau; therapeutic; therapy; treatment; tryptophan; type; use; years cache: cord-0066794-iw0rjwtd.txt plain text: cord-0066794-iw0rjwtd.txt item: #154 of 251 id: cord-0069949-cqbij1vk author: Lara-Barba, Eliana title: Role of microRNA Shuttled in Small Extracellular Vesicles Derived From Mesenchymal Stem/Stromal Cells for Osteoarticular Disease Treatment date: 2021 words: 8394 flesch: 21 summary: Osteoarticular diseases (OA) and rheumatoid arthritis (RA) are chronic autoimmune/inflammatory and age-related diseases that affect the joints and other organs. Cell therapy using mesenchymal stem/stromal cells (MSCs) is an alternative treatment due to their immunomodulatory and tissue differentiation capacity. Recently, acellular therapy based on MSC secreted factors has raised the attention of several studies. keywords: activation; activity; adipose; analysis; apoptosis; applications; arthritis; articular; associated; autoimmune; biological; bmp; bone; cargo; cartilage; cells; chondrocytes; clinical; collaborators; communication; degenerative; degradation; delivery; development; differentiation; diseases; effects; exosomal; exosomes; expression; extracellular; fibroblast; fluid; hand; homeostasis; homing; human; il-10; immune; immunomodulatory; immunosuppressive; increase; induced; inflammation; inflammatory; inhibition; inhibits; joint; key; knee; levels; like; main; marrow; mediators; mesenchymal; mesenchymal stem; mesenchymal stromal; mice; microrna; mir-140; mir-146a; mir-155; mir-22; mirnas; model; molecules; mscs; non; osteoarthritis; osteoblast; pathogenesis; pathway; patients; phase; plasma; population; potential; processes; proliferation; promising; properties; proteins; receptor; regeneration; regulation; response; review; rheumatoid; role; safety; sevs; signaling; significant; small; stem; stem cells; stromal; studies; study; synovial; target; tgf; therapeutic; therapies; therapy; tissue; tnf; treatment; trials; type; use; vesicles; vivo cache: cord-0069949-cqbij1vk.txt plain text: cord-0069949-cqbij1vk.txt item: #155 of 251 id: cord-0070096-2vaquykw author: Ali, Shabana Amanda title: A Network Biology Approach to Understanding the Tissue-Specific Roles of Non-Coding RNAs in Arthritis date: 2021 words: 4240 flesch: 30 summary: Non-coding RNAs are key regulators of gene expression in the musculoskeletal system. They are transcribed from DNA but not translated into protein. MicroRNAs have received widespread attention for their roles in osteoarthritis and rheumatoid arthritis. LncRNAs act as molecular decoys, sequestering miRNAs and preventing interaction with gene targets. keywords: apoptosis; approach; arthritis; axes; axis; biological; biology; cartilage; cell; chondrocytes; circrnas; circular; coding; coding rnas; computational; curation; data; database; date; different; disease; effects; example; expression; factors; fibroblast; figure; fls; function; gene; human; inflammation; integration; interactions; key; like; lncrna; long; malat1; matrix; microrna; mirnas; molecular; molecules; multiple; naming; neat1; networks; nomenclature; non; osteoarthritis; proliferation; protein; recent; rheumatoid; rnas; specific; studies; synoviocytes; targets; tissue cache: cord-0070096-2vaquykw.txt plain text: cord-0070096-2vaquykw.txt item: #156 of 251 id: cord-0070325-pd9e926j author: Mustafa, Ghulam title: Identification of Peptides as Novel Inhibitors to Target IFN-γ, IL-3, and TNF-α in Systemic Lupus Erythematosus date: 2021 words: 4665 flesch: 45 summary: Systemic Lupus Erythematosus (SLE) is an autoimmune disease with a common type of lupus that causes tissue and organ damage due to the wide spread of inflammation. Twenty anti-inflammatory peptides from plant and animal sources were docked as ligands or peptides counter to proinflammatory cytokines. The peptide DEDTQAMMPFR could be used as a potential drug candidate to target IFN-γ, IL-3, and TNF-α. keywords: acids; active; adaptive; amino; analysis; anti; approach; autoantibodies; autoimmune; autoimmunity; binding; cells; clinical; control; counter; current; cytokines; dedtqammpfr; different; disease; disorders; docking; drug; elevated; energy; erythematosus; figure; frdehkk; haddock; ifn; il-3; immunity; inflammation; inflammatory; innate; interactions; ligand; lupus; molecular; molecules; pathogenesis; pathways; patients; pattern; peptide; pocket; potential; production; protein; protein docking; qepqesqq; receptor; residues; role; score; signaling; simulation; sle; strong; structure; studies; study; systemic; tnf; treatment; tumor cache: cord-0070325-pd9e926j.txt plain text: cord-0070325-pd9e926j.txt item: #157 of 251 id: cord-0070899-gke00q25 author: Gholami, Ahmad title: Cost-Effectiveness Analysis of Biopharmaceuticals for Treating Rheumatoid Arthritis: Infliximab, Adalimumab, and Etanercept date: 2021 words: 5251 flesch: 41 summary: Infliximab is more cost-effective than Adalimumab and Etanercept in treating rheumatoid arthritis in Iran. The study was carried out on 154 patients with RA in Fars province taking these medications. keywords: acceptability; activity; adalimumab; analysis; area; arthritis; biological; biomed; biopharmaceuticals; capita; cost; curve; das-28; data; disease; economic; effectiveness; effectiveness analysis; effects; etanercept; gdp; health; higher; icer; incremental; infliximab; international; iran; joint; life; line; lower; manuscript; markov; mean; medications; model; moderate; patients; present; present study; qaly; questionnaire; ratio; research; results; rheumatoid; rheumatoid arthritis; sensitivity; severe; simulations; studies; study; study results; therapy; threshold; times; tnf; tofacitinib; treatment; utility; way cache: cord-0070899-gke00q25.txt plain text: cord-0070899-gke00q25.txt item: #158 of 251 id: cord-0071025-bkalx73u author: Valori, Miko title: CD8+ cell somatic mutations in multiple sclerosis patients and controls—Enrichment of mutations in STAT3 and other genes implicated in hematological malignancies date: 2021 words: 6592 flesch: 44 summary: Valori, Miko, Jansson, Lilja, Tienari, Pentti Jansson and Lilja studied CD8+ cell somatic mutations in MS patients and controls. They found activating STAT3 mutations and enrichment to SMARCA2, DNMT3A, SOCS1 and PPP3CA genes. The mutations showed statistically significant clustering to the STAT3 gene. keywords: advantage; age; allelic; analysis; artefacts; autoimmune; base; blood; calling; cancer; cases; cd8; cells; clonal; clones; common; comparison; context; controls; criteria; data; deleterious; depth; detectable; different; disease; dna; dnmt3a; enrichment; errors; expected; false; filtering; fraction; frequency; genes; germline; groups; high; hprt; human; large; leukemia; library; likely; mean; median; ms patients; multiple; mutated; mutations; noise; nonsynonymous; normal; number; order; panel; participants; patients; positives; possible; preparation; quality; reads; reference; rna; role; samples; sclerosis; sensitivity; sequencing; signaling; single; size; smarca2; somatic; somatic mutations; stat3; study; subject; synonymous; table; test; total; variant cache: cord-0071025-bkalx73u.txt plain text: cord-0071025-bkalx73u.txt item: #159 of 251 id: cord-0071358-8v1oemlt author: Shakeel, Faiyaz title: Investigating Antiarthritic Potential of Nanostructured Clove Oil (Syzygium aromaticum) in FCA-Induced Arthritic Rats: Pharmaceutical Action and Delivery Strategies date: 2021 words: 7544 flesch: 44 summary: Shakeel, Faiyaz, Alam, Prawez, Ali, Abuzer, Alqarni, Mohammed H., Alshetaili, Abdullah, Ghoneim, Mohammed M., Alshehri, Sultan and Amena studied the antiarthritic potential of nanostructured Clove Oil (Syzygium aromaticum) in FCA-Induced Arthritic Rats. Arthritis is a chronic condition caused by a disruption in the production of pro-inflammatory cytokines and enzymes. keywords: acid; activity; analysis; antiarthritic; aqueous; area; arthritis; blood; cell; clove; combination; compartment; complete; conc; concentration; control; cytokines; delivery; development; diagrams; different; diffusion; drug; effect; enhanced; enzymes; essential; evaluation; fca; figure; flux; formulation; gel; group; high; hptlc; il-6; increase; inflammatory; interfacial; lcs; levels; lipid; low; method; microfluidization; min; mix; nanoemulsion; nanoparticles; neat; oil; paw; percent; performance; pharmaceutical; phase; potential; presence; production; protein; quantity; rats; receiver; release; results; rheumatoid; room; rpm; samples; serum; size; skin; smix; solid; stability; standard; study; surface; surfactant; system; table; temperature; tension; test; thermodynamic; time; titration; tnf; topical; treatment; tween; viscosity; volume; water cache: cord-0071358-8v1oemlt.txt plain text: cord-0071358-8v1oemlt.txt item: #160 of 251 id: cord-0072355-wxvkobsi author: Tsiogkas, Sotirios G. title: Effect of Crocus sativus (Saffron) Intake on Top of Standard Treatment, on Disease Outcomes and Comorbidities in Patients with Rheumatic Diseases: Synthesis without Meta-Analysis (SWiM) and Level of Adherence to the CONSORT Statement for Randomized Controlled Trials Delivering Herbal Medicine Interventions date: 2021 words: 9102 flesch: 40 summary: Saffron is a spice derived from the Crocus sativus L. flower and is a popular complementary and alternative medicine among patients with rheumatic diseases (RDs). The present systematic review aimed to summarize the available evidence regarding the efficacy of supplementation with saffron on disease outcomes and comorbidities in patients with RD diagnoses. The majority of trials demonstrated some concerns regarding overall bias. keywords: active; activity; adherence; analysis; antioxidant; anxiety; arms; arthritis; assessment; bias; cells; clinical; consort; count; criteria; crocus; das-28; data; depression; diagnosis; disease; duration; effect; efficacy; esr; fatigue; fibromyalgia; figure; global; health; herbal; high; impact; index; inflammatory; intervention; iran; joint; lack; majority; mda; medicine; meta; months; ons; osteoarthritis; outcomes; oxidative; pain; participants; patients; present; protein; quality; questionnaire; randomized; rcts; rds; reduced; reporting; research; results; review; rheumatoid; risk; saffron; sativus; scale; score; specific; standardization; studies; study; supplementation; swim; syndrome; synthesis; systematic; total; treatment; treg; trials cache: cord-0072355-wxvkobsi.txt plain text: cord-0072355-wxvkobsi.txt item: #161 of 251 id: cord-0072795-uezqcu8c author: Shin, Min Jun title: Stem Cell Mimicking Nanoencapsulation for Targeting Arthritis date: 2021 words: 9871 flesch: 28 summary: MSCs are promising regenerative therapy due to their ability to migrate toward damaged tissues. MSCs have many advantages in the treatment of malignant diseases, particularly rheumatoid arthritis (RA). MSC mimicking nanoencapsulations are an alternative strategy that does not involve using MSC's or bioengineered ones. keywords: ability; addition; adhesion; adipose; advantages; alternative; anti; applications; arthritis; artificial; autoimmune; blood; bone; cancer; capacity; cell membrane; cell migration; cells; challenges; chemokine; cistain; clinical; coated; coating; cord; core; current; cxcl12; cxcr4; cytokines; delivery; different; disease; drug; drug delivery; ectosomes; editing; effects; efficacy; endothelial; engineering; enhanced; evs; example; exosomes; extracellular; factor; figure; fusion; future; gene; genetic; genome; growth; high; homing; human; immune; increase; induced; inflamed; inflammation; inflammatory; injury; involved; joints; ligand; liposomes; loaded; low; macrophages; marrow; materials; mechanism; membrane; membrane vesicles; mesenchymal; mesenchymal stem; mesenchymal stromal; mice; migration; migratory; mimicking; model; molecules; msc membrane; msc migration; mscs; nanoencapsulation; nanoparticles; natural; new; non; nps; polymer; potential; process; production; promising; properties; protein; receptors; repair; research; response; review; rheumatoid; rna; rolling; safety; selectin; similar; sites; size; small; source; specific; stem; stem cells; strategies; strategy; stromal; stromal cells; structure; studies; surface; systemic; systems; targeted; targeting; therapeutic; therapy; tissues; treatment; tropism; tumor; umbilical; use; vectors; vesicles; viral; vivo cache: cord-0072795-uezqcu8c.txt plain text: cord-0072795-uezqcu8c.txt item: #162 of 251 id: cord-0073012-p2z3fs9r author: Wang, Shaohui title: Practical Implementation of Artificial Intelligence-Based Deep Learning and Cloud Computing on the Application of Traditional Medicine and Western Medicine in the Diagnosis and Treatment of Rheumatoid Arthritis date: 2021 words: 11633 flesch: 21 summary: Wang, Shaohui, Hou, Ya, Li, Xuanhao, Meng, Xianli, Zhang, Yi, Wang, Xiaobo and others discuss the application of AI-assisted deep learning and cloud computing on the diagnosis and treatment of rheumatoid arthritis. keywords: acid; activation; active; activity; addition; advantages; adverse; algorithms; analysis; anti; application; approaches; arthritis; article; articular; artificial; assessment; autoimmune; available; bath; big; biomarkers; blood; body; bone; cancer; candidate; cartilage; cause; cells; changes; chinese; chinese medicine; clinical; clinical diagnosis; cloud; cold; collagen; combination; complex; compounds; computer; computing; conventional; current; cytokines; dai; damage; data; database; deep; deep learning; destruction; detection; development; diagnosis; different; differentiation; digital; discovery; disease; dmards; drug; early; effective; effects; efficacy; efficient; et al; ethnic; ethnic medicine; evaluation; external; factors; fibroblasts; field; figure; fire; fluorescence; frontiers; gcs; health; herbal; high; huang; image; imaging; important; induced; inflammation; inflammatory; information; integrated; integration; intelligence; joint; learning; long; lung; machine; macrophages; management; mechanisms; medical; medicine; methods; methotrexate; models; molecular; moxibustion; mri; mtx; multiple; network; neural; neutrophils; new; non; novel; optical; pain; pathogenesis; pathological; pathway; patients; pharmacological; pharmacology; platform; potential; practice; prediction; present; process; prognosis; progress; protein; ra diagnosis; ra disease; ra patients; reactions; reasonable; recent; related; research; response; review; rheumatoid; rheumatoid arthritis; rheumatologists; risk; role; scientific; screening; segmentation; serum; signal; single; skin; specific; strategies; study; support; symptoms; synovial; system; target; tcm; technology; theory; therapeutic; therapies; therapy; tibetan; time; tnf; tomography; traditional; traditional medicine; treatment; understanding; unique; use; volume; wang; wang et; western; wind; www.frontiersin.org; years cache: cord-0073012-p2z3fs9r.txt plain text: cord-0073012-p2z3fs9r.txt item: #163 of 251 id: cord-0073836-j1mvy902 author: Molero-Chamizo, Andrés title: Non-Invasive Transcutaneous Vagus Nerve Stimulation for the Treatment of Fibromyalgia Symptoms: A Study Protocol date: 2022 words: 6255 flesch: 34 summary: Fibromyalgia is a chronic disease that causes chronic pain, fatigue, insomnia, sleep disorders, affective and emotional disorders, depression and anxiety, cognitive impairment, paresthesia, allergy symptoms, joint stiffness, tendinopathy, neuropathic and rheumatologic symptoms, chemical and skin hypersensitivity, irritable bowel syndrome, and other symptoms. Molero-Chamizo, Andrés, Nitsche, Michael A., Bolz, Armin, Andújar Barroso, Rafael Tomás, Alameda Bailén, José R., García Palomeque, Jesús Carlos, Rivera-Urbina, Guadalupe Nathzidy propose a non-invasive keywords: activity; auricular; auricular vagus; autonomic; axillary; baseline; bdi; bpi; brain; branch; central; cervical; chronic; clinical; control; cytokine; depression; effects; electrodes; factor; fibromyalgia; figure; fiqr; frequency; group; heart; high; immune; inflammatory; intensity; intervention; invasive; left; levels; life; measurements; measures; nerve; nerve stimulation; nervous; non; outcome; pain; patients; pgic; physiological; post; primary; pro; protocol; psqi; quality; rate; review; safety; scores; secondary; sessions; sham; sleep; spanish; stimulation; studies; study; symptoms; system; transcutaneous; treatment; tvns; vagal; vagal stimulation; vagus; vagus nerve; variability; week cache: cord-0073836-j1mvy902.txt plain text: cord-0073836-j1mvy902.txt item: #164 of 251 id: cord-0074606-q4kko9sm author: Soós, Boglárka title: Angiotensin Converting Enzyme Activity in Anti-TNF-Treated Rheumatoid Arthritis and Ankylosing Spondylitis Patients date: 2022 words: 5629 flesch: 44 summary: Soós, Boglárka, Fagyas, Miklós. Horváth, Ágnes, Végh, Edit, Pusztai, Anita, Czókolyová, Monika, Hamar, Attila, Pethő, Zsófia, Bodnár, Nóra, Kerekes, György, Hodosi, Katalin, Szekanecz, Éva, Szamosi, Szilvia, Szűcs, Gabriella, Papp, Zoltán and Zoltan are the authors of the study. keywords: ace; ace levels; ace2; ace2 activity; activity; alpha; analysis; angiotensin; anti; arthritis; associated; baseline; biologics; cardiovascular; carotid; changes; cohort; concentration; controls; converting; crp; data; disease; duration; effects; enzyme; factor; figure; fmd; healthy; higher; imt; increased; inflammation; inflammatory; inhibition; inhibitors; levels; mean; mixed; pathophysiology; patients; production; ratios; redistribution; renin; rheumatoid; serum; spondylitis; studies; study; synovial; system; table; therapy; time; tissue; tnf; treatment; vascular; year cache: cord-0074606-q4kko9sm.txt plain text: cord-0074606-q4kko9sm.txt item: #165 of 251 id: cord-0075000-83k6qcir author: Wu, Ning title: Network Pharmacology and Molecular Docking Study of the Chinese Miao Medicine Sidaxue in the Treatment of Rheumatoid Arthritis date: 2022 words: 10831 flesch: 44 summary: SX is a Chinese herbal medicine prescribed for treating rheumatoid arthritis (RA). The study used network pharmacology to identify the key targets and signaling pathways in the treatment of RA. The main functional pathways involving these key targets include PI3K-AKT signaling pathway, TNF signaling pathway and NF-κB signaling pathway. SX can improve joint swelling in Collagen-induced arthritis rats, reduce inflammatory cell infiltration and angiogenesis in joint synovial tissue. keywords: 20g; 40g; action; activation; active; activity; addition; akt; analysis; animal; anti; arthritis; binding; biological; blood; bone; cartilage; cells; changes; chemical; chinese; cia; circle; collagen; complex; components; compounds; content; control; cytokines; database; degree; degree value; design; destruction; development; diagram; difference; differentiation; disease; docking; drug; effect; energy; experimental; expression; factors; figure; genes; greater; green; groups; gtw group; herbal; hind; il-6; immune; important; inflammation; inflammatory; ingredient; inhibit; interaction; joint; kegg; key; kg group; kinase; large; levels; main; mechanism; medicine; miao; mod group; molecular; molecules; mrna; multiple; network; number; orange; p<0.01; pannus; pathway; patients; pharmacological; pharmacology; pi3k; potential; ppi; process; proliferation; protein; ptgs2; rats; receptor; regulation; related; response; results; rheumatoid; rheumatoid arthritis; role; score; severe; signaling; significant; sitosterol; small; stat1; studies; study; supplementary; swelling; sx active; sx treatment; synovial; table; targets; tcm; therapeutic; tissue; tnf; total; traditional; treatment; value; vascular; vegf; vessels; κbp65 cache: cord-0075000-83k6qcir.txt plain text: cord-0075000-83k6qcir.txt item: #166 of 251 id: cord-0075535-9a9i0pun author: Kriegsmann, Mark title: Synoviale Veränderungen bei Erkrankungen des rheumatologischen Formenkreises und Differenzialdiagnosen date: 2022 words: 1893 flesch: 23 summary: The investigation of alterations to synovial tissue can contribute to the diagnosis of joint and systemic diseases. The histological picture of granulomatous synovitis can be caused by a mycobacterial infection, sarcoidosis and foreign body reactions. The diagnosis of rheumatoid arthritis is based on the American College of Rheumatology criteria. keywords: agentien; akute; als; american; amyloidosen; arthritis; auch; auf; auftreten; bei; beobachtet; beschrieben; charakterisiert; college; dar; das; dass; der; des; diagnose; diagnosis; die; diese; diseases; dna; durch; eine; entzündungen; erkrankungen; fluid; für; granulomatous; granulomatöse; histological; infection; infektionen; ist; joint; kann; können; methods; microorganisms; mir-146a; mirna; mit; mittels; molecular; muster; nach; neben; nicht; oder; patienten; pcr; rahmen; rare; reactive; reaktiven; review; rheumatoid; rna; sarcoidosis; seltene; septic; sich; sind; subtyping; synovialflüssigkeit; synovialis; tissue; tof; trachomatis; tunica; und; verursacht; veränderungen; von; werden; wird; wurde; zur cache: cord-0075535-9a9i0pun.txt plain text: cord-0075535-9a9i0pun.txt item: #167 of 251 id: cord-0075776-p15c4r7q author: Khaleel, Anas title: Pathway analysis of smoking-induced changes in buccal mucosal gene expression date: 2022 words: 4005 flesch: 38 summary: Cigarette smoking is the leading preventable cause of death worldwide and the most common cause of oral cancers. The study aims to provide a deeper understanding of the molecular pathways in the oral cavity that are altered by exposure to cigarette smoke. The gene expression dataset of buccal mucosa samples from smokers and never smokers was downloaded from The National Center for Biotechnology Information's (NCBI) Gene Expression Omnibus (GEO) repository. Differential expression was ascertained via NCBI’s GEO2R software, and Ingenuity Pathway Analysis (IPA) software was used to perform a pathway analysis. 459 genes were found to be significantly differentially expressed in smoker bucca. 261 genes were over keywords: analysis; batf3; buccal; buccal mucosa; cancer; carcinoma; cells; cellular; chd5; cigarette; copd; craniosynostosis; current; data; dataset; disease; effect; epithelial; exposure; expression; figure; genes; genetic; human; il6r; interactions; ipa; list; lung; macrophages; molecular; mucosa; ncbi; nitric; non; number; oxidative; oxide; oxygen; pathways; production; protein; qki; reactive; regulator; results; risk; samples; significant; smad2; smoker; smoker buccal; smoking; software; stress; study; table; tissue; tobacco; total; tp53; tumors; upstream; years cache: cord-0075776-p15c4r7q.txt plain text: cord-0075776-p15c4r7q.txt item: #168 of 251 id: cord-0076398-nwbai6qr author: Zhang, Lei title: Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment date: 2022 words: 9725 flesch: 41 summary: Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis. Prussian blue nanoparticles (BNPs) can effectively relief oxidative stress by catalyzing oxygen radicals. PBNPs has been approved by the Food and Drug Administration. keywords: ability; activation; addition; advanced; akt; analysis; ankle; anti; apoptosis; arthritis; assay; blue; bone; cartilage; cells; chondrocytes; cia; collected; concentration; cytokines; cytometry; damage; days; delivery; destruction; dir; dir@upb; drug; early; effective; effects; efficacy; exo; exosomes; expression; factors; fibroblast; fig; figs; flow; fls; fluorescence; free; good; great; group; il-1β; images; imaging; increased; induced; inflamed; inflammation; inflammatory; joints; key; late; like; lps; mice; micro; model; mouse; nanoparticles; nes; neutrophil; normal; oxidative; oxygen; pathway; patients; paws; pbnps; pbs; pi3k; potential; progression; prussian; raw264.7; receptor; region; results; rheumatoid; role; ros; samples; serum; signal; signaling; solution; stage; staining; stress; surface; synovial; synoviocytes; synovitis; synovium; system; targeted; targeting; th17; therapeutic; therapy; time; tnf; treatment; treg; upb; usa; vivo cache: cord-0076398-nwbai6qr.txt plain text: cord-0076398-nwbai6qr.txt item: #169 of 251 id: dpc-183 author: Blum, Andreas title: Dermoscopic appearance of an amelanotic mucosal melanoma date: 2016 words: 1086 flesch: 47 summary: A female in her seventies, skin phototype II, presented to her gynecologist with a new lesion on the inside of her right labia minora. She had a history of rheumatoid arthritis requiring treatment with methotrexate for 20 years and adalimumab for 10 years. She was prescribed acyclovir 5% cream and a hydrocortisone 1% / clotrimazole 1% cream for two weeks. A biopsy was taken of a part of the nodule and she was diagnosed with an amelanotic melanoma. keywords: amelanotic; appearance; blum; case; copyright; dermatol; dermatology; dermoscopy; diagnosis; figure; germany; lesions; melanoma; mucosal; pigmented; polymorphous; right; vessels; white; years cache: dpc-183.pdf plain text: dpc-183.txt item: #170 of 251 id: dr-3203 author: Mola, Federica title: Infliximab-induced intertriginous psoriasis in patient with Crohn's desease date: 2011 words: 1050 flesch: 45 summary: Infliximab-induced intertriginous psoriasis in a 32-year-old male patient with Crohn’s disease of the ileum and descending colon was treated with infliximab at the dose of 5 mg/Kg at the week 0, 2, 6 and afterwards every 14 weeks. After the fifth infusion he developed erythematous patches with peripheral scaling in the axillary folds and inguinal areas and sebopsoriasis on the face and neck. keywords: anti; case; cells; crohn; dermatology; disease; e40; factor; figure; flexural; infliximab; infusion; inhibitor; necrosis; patient; psoriasis; report; skin; therapy; tnfα; treatment; tumor cache: dr-3203.pdf plain text: dr-3203.txt item: #171 of 251 id: dti-1304 author: Kameda, Hideto title: Platelet-Derived Growth Factor as a Therapeutic Target for Systemic Autoimmune Diseases date: 2007 words: 6647 flesch: 51 summary: Imatinib mesylate inhibits the activation of PDGF receptor as well as c-Abl, Bcr and c-Kit tyrosine kinases. It has been widely used for the treatment of chronic myeloid leukemia and gastroin-testinal stromal tumors. Imatinib may overcome the limitations of current therapeutic strategy with corticosteroids and immunosuppressive agents for refractory diseases. keywords: abl; activation; activity; agents; american; ammation; anti; antibodies; antibody; arthritis; autoimmune; bcr; bleomycin; broblast; brosis; brotic; cacy; cells; chronic; clinical; corticosteroids; diseases; drug; druker; ecm; effi; et al; expression; factor; false; fi brosis; gene; glomerulonephritis; growth; heldin; idiopathic; ild; imatinib; infl; inhibited; inhibition; inhibits; insights; interstitial; kameda; kameda et; kinase; leukemia; lung; lupus; mesangial; mesylate; mice; model; molecular; monoclonal; nephritis; patients; pdgf; platelet; production; proliferation; proteins; pulmonary; rats; receptor; refractory; renal; response; rheumatoid; saitama; sclerosis; sfl; signaling; signifi; society; specifi; ssc; synovial; systemic; target; targeted; therapeutic; thoracic; treatment; true; tyrosine; uip; vascular; vivo cache: dti-1304.pdf plain text: dti-1304.txt item: #172 of 251 id: dti-1313 author: Nishida, Seiichiro title: Cardiovascular Pharmacology of Sinomenine: The Mechanical and Electropharmacological Actions date: 2007 words: 4619 flesch: 54 summary: Sinomenine is one of the alkaloids extracted from Chinese medical plant Sinomenium acutum Rehder et Wilson. Sinomenine has been used for Rheumatoid arthritis and heart failure. It is an anti-inflamatory and immunomodulative drug. It suppresses Ca2+ current and suppresses dysrhythmias. keywords: actions; acutum; al.indd; ammatory; anti; aorta; ca2; cardiac; cardiomyocytes; cardiovascular; cells; channels; chinese; concentration; current; dependent; drug; effects; endothelium; et al; failure; false; fig; guinea; heart; immunomodulative; infl; insights; ionic; mechanisms; min; modulation; mokuboito; muscle; n =; nishida; pharmacological; pharmacology; pig; potential; rat; rheumatic; satoh; sinomenine; smooth; target; true; vasorelaxation cache: dti-1313.pdf plain text: dti-1313.txt item: #173 of 251 id: dti-1347 author: Roth, Bodil title: Microscopic Colitis is Associated with Several Concomitant Diseases date: 2013 words: 4007 flesch: 56 summary: Bodil Roth, Jonas Manjer and Bodil Ohlsson are studying the relationship between Microscopic Colitis (MC) and a number of autoimmune diseases in middle-aged women with the disease. They found that MC patients have an increased prevalence of several autoimmune diseases, including high levels of former or current smokers. keywords: 2013:7; age; arthritis; asthma; autoimmune; cancer; characteristics; clinical; cohort; colitis; collagenous; concomitant; controls; current; days; diabetes; diseases; drinking; drug; education; employment; factors; gastroenterol; group; http://www.la-press.com; hypertension; insights; lymphocytic; median; mellitus; microscopic; month; patients; population; present; prevalence; primary; range; rheumatoid; smokers; smoking; studies; study; subjects; table; target; treatment; university; wine; women; years cache: dti-1347.pdf plain text: dti-1347.txt item: #174 of 251 id: estad-29472 author: Salazar, Juan Carlos title: THREE STATE MARKOV MODEL: COMPARING THREE PARAMETERIZATIONS OF THE TRANSITION INTENSITY RATE. APPLICATION TO RHEUMATOID ARTHRITIS DATA date: 2007 words: 6819 flesch: 55 summary: Juan Carlos Salazar, René Iral Palomino, Enrique Calvo, Adriana Rojas, María Eugenia Hincapié, Juan Manuel Anaya, Francisco Javier Díaz, and Juan Carlos Anaya apply the Three State Markov model of the transition intensity rate to rheumatoid arthritis data. keywords: absorbente; acuerdo; adelante; andersen; artritis; asociado; ausencia; años; cada; carlos; colombiana; colombiana de; como; con; con el; covariables; data; datos; de andersen; de estadística; de intensidad; de las; de referencia; de simulación; de transición; de tres; de un; dentro; diferentes; ecuaciones; edad; ejemplo; el modelo; en el; en la; enfermedad; entre; estados; estadística; este; estimaciones; estimación; estimadores; estimar; esto; estudio; está; figura; funciones; función; gill; grupo; hacia; heijde; importante; inc; intensidad; interés; juan; kolmogorov; las; las tasas; leve; log; logístico; longitudinal; los; mail; manos; markov; markov de; medio; modelo; modelo de; moderado; muestral; más; máximo; método; naive; new; número; observa; obtener; p11(t; paciente; para; parametrizaciones; participante; por; presencia; primera; proceso; puede; que; referencia; representa; reumatoidea; revista; salazar; sección; severo; simulación; sistema; son; state; tabla; tamaño; tasas; tasas de; tiempo; tiene; trabajo; transiciones; transición; tres; una; usando; valores; van; vector; verosimilitud; visitas; york; α12; α13; α23; αij; α∗ij; λ12 cache: estad-29472.pdf plain text: estad-29472.txt item: #175 of 251 id: fe-160 author: Benucci, Maurizio title: Budget impact analysis of the use of rituximab in the treatment of rheumatoid arthritis in Italy date: 2009 words: 7682 flesch: 52 summary: Budget impact analysis was performed to evaluate the cost implications for the Italian National He-alth Service of the introduction of rituximab (RTX) in the treatment of rheumatoid arthritis. The adoption of RTX as a second line produced a substantial saving in total costs. keywords: abat; abatacept; acquisizione; adal; adalimumab; alla; alle; alpha; alternative; analisi; analysis; anche; anno; annual; anti; arthritis; atnf; attivo; basata; base; benucci; biologica; budget; calcolato; caratteristiche; che; circa; code; come; con; con rtx; congress; considerato; costo; cui; cura; dati; deceduti; degli; dei; dei pazienti; del; della; dell’artrite; dell’utilizzo; di rtx; differenze; diritti; dmard; dopo; economico; effectiveness; eleventh; esami; etan; etan adal; etanercept; european; factor; fallimento; farmaci; fra; gestione; grado; health; iannazzo; impact; inferiore; infine; infl; infl etan; infliximab; inn; inn rtx; innovativa; international; ispor; italia; kielhorn; lavoro; linea; linea biologica; medio; mentre; metotressato; modello; monitoraggio; monoterapia; nazionale; necrosis; nei; nel; nelle; non; numero; nuovi; ogni; pari; parte; passa; patients; patologia; pazienti; pazienti con; percorsi; permette; più; popolazione; premedicazioni; prevede; primo; primo anti; prodotto; prosecuzione; punto; quella; questo; reumatologo; rheumatoid; riassunto; riservatifarmeconomia; risorse; rispetto; risulta; rituximab; rtx; sabadini; sanitarie; seconda; seconda linea; seed; seguito; sia; solo; solo atnf; somministrato; somministrazione; sono; ssn; stato; stimato; strategia; studio; study; successivi; sulla; tabella; tasso; tempo; terapeutici; terapia; terza; therapy; tnfα; totale; trattamento; trattamento con; trattati; treatment; tumour; tutti; una; unità; use; uso; utilizzato; value; variazione; vengono; viene; vita; year; è stato cache: fe-160.pdf plain text: fe-160.txt item: #176 of 251 id: fe-212 author: de Portu, Simona title: Cost-utility analysis of abatacept in rheumatoid arthritis in Italy date: 2008 words: 4543 flesch: 57 summary: Simona de Portu, Lorenzo Giovanni Mantovani, Ignazio Olivieri, and others studied the cost-utility of abatacept, a new selective T-cell co-stimulation modulator for rheumatoid arthritis in Italy. They found it to be more effective than anti-TNFs. keywords: abatacept; acr; adalimumab; alla; altri; analisi; anni; annuale; anti; arthritis; assessment; assunzioni; basale; baseline; biologici; cambiamento; che; clinical; come; con; costo; data; dei; del; della; dell’haq; diretti; dmards; dopo; dose; economico; efficacia; engl; et al; etanercept; età; factor; farmaci; farmeconomia; gli; guadagnato; hanno; haq; health; iii; impatto; infatti; infliximab; italia; kremer; malattia; mantovani; med; mesi; methotrexate; metotressato; modello; national; necrosis; nei; nel; nell’artrite; non; ogni; olivieri; orizzonte; pari; patients; pazienti; percorsi; portu; progressione; punteggio; qaly; qualità; rapporto; response; rheumatoid; rheumatoid arthritis; rheumatology; risposta; risultati; seed; sensibilità; settimane; sia; soglia; sono; stato; studio; study; tabella; tale; tasso; temporale; terapeutici; terapia; therapy; tnfs; trattamento; treatment; trial; tumor; tutti; una; utilità; vita; wolfe; years cache: fe-212.pdf plain text: fe-212.txt item: #177 of 251 id: fe-764 author: Mantovani, Lorenzo G. title: Trattamento con etanercept dei soggetti con artrite reumatoide in Italia: considerazioni economiche date: 2003 words: 3328 flesch: 54 summary: L’artrite reumatoide (AR) is a chronic inflammatory disease affecting the joints and leading to work disability in half of the patients. The prevalence in Italy is estimated to be around 0.5%. In Italia, the preva-lenza dell’AR sia lo 0,5% (circa 300,000 malati). Two anti-TNF-α agents are available in Italy: etanercept and infliximab. keywords: 2001; alla; all’indirizzo; anche; anti; arthritis; artrite; bansback; che; circa; colleghi; con; considerazioni; costo; dal; day; dei; della; diritti; disponibile; dosaggio; dose; drugs; durante; economiche; effettuata; efficacia; enamittes; etanercept; etnof; euro; farmaci; farmeconomia; fiale; frequenza; gm01; gm3; hanno; hospital; http://www.eular.org/eular2002/abstract.cfm; incrementale; inferiore; infliximab; italia; lavoro; methotrexate; nei; nel; nice; non; ogni; patients; pazienti; percorsi; periodo; peso; più; qaly; questi; responders; rheumatoid; riservati; rispetto; risultati; seed; settimane; sia; soggetti; somministrazione; sono; studio; suppl; suppone; tabella; terapeutici; terapia; terapia con; tnf; trattamento; treatment; tutti; una; utilità; web cache: fe-764.pdf plain text: fe-764.txt item: #178 of 251 id: fe-771 author: Colombo, G. L. title: Valutazione economica di Infliximab (Remicade®) vs Etanercept (Enbrel®) nel trattamento dell’artrite reumatoide date: 2003 words: 5297 flesch: 51 summary: Infliximab (Remicade) vs. Etanercept (Enbrel) is the best treatment for Rheumatoid arthritis (AR) in Italy. Arthritoid arthritis is one of the most severe chronic pathologies affecting the whole organism. The prevalence of AR in Italy is about 0.5%. The introduction of new drugs with anti-inflammatory and anti-tumor necrotic agents is a great advance in the management of AR. keywords: .rpc; .ttes; .ttes8ingoiop; 34,0; 50,0; 6/2/0.ttes; alaif; alla; alle; analisi; anche; anni; anno; anti; arthritis; azneuqerf; base; caso; che; circa; con; considerando; costi; cui; dal; dati; degli; dei; del; della; dell’artrite; di infliximab; diritti; domicilio; drug; durante; e6/2/0.ttesalla; economica; elanosrep; elatot; elaunna; ena; enbrel; enoizartsinimmos; enoizefnoc; essere; etanercept; euro; farmaci; farmeconomia; fatto; gli; indiretti; infermiere; infliximab; infusione; invece; iratinas; itapucco; itunim; lavoro; m001; malattia; mattart; mentre; methotrexate; mittes; mraf; nel; nell’analisi; nhs; non; numero; occupati; oiratinu; ore; ospedalieri; otne; otso c; otsoc; pari; pazienti; percorsi; perdita; personale; più; popolazione; primo; punto; relativi; remicade; rep; reumatoide; riservati; risorse; risparmio; risultati; secondo; seed; sensibilità; settimane; si è; sia; società; solo; somministrazione; sono; ssn; stata; stessa; studio; sui; sulla; tabella; tempi; terapeutici; terapie; tnf; totale; tpecrenate; trattamento; treatment; tutti; una; un’analisi; valori; valutazione; vista; àtin cache: fe-771.pdf plain text: fe-771.txt item: #179 of 251 id: fe-795 author: Zaniolo, Orietta title: Neridronato nel trattamento dell’osteogenesi imperfetta: prestazioni cliniche ed economiche di un farmaco orfano date: 2004 words: 10079 flesch: 56 summary: Neridronate is an injectable amino-bisphosphonate. It is used for the treatment of osteoge-thusnesis imperfecta (OI). It is also used to treat postmenopausal osteoporosis, Paget’s disease and rheumatoid arthritis. keywords: acido; adami; adulti; affetti; alcalina; alcuni; alendronate; alla; alle; almeno; altri; anche; ancora; anni; arthritis; attività; attivo; aumento; avere; avevano; bambini; base; baseline; bifosfonati; biochimici; biodisponibilità; bisphosphonates; bmd; bone; calcio; caratteristiche; carico; casi; caso; causa; che; che il; children; chiodi; circa; ciò; classe; clinical; cliniche; clinici; clodronato; colleghi; come; con; con un; concentrazione; condotto; conseguente; contrario; controllo; corso; crescita; cui; cure; dai; dal; dati; deformità; degli; dei; dei pazienti; del; del farmaco; della; dell’osso; dell’osteogenesi; dell’osteogenesi imperfetta; dell’osteoporosi; densità; di un; diminuzione; dimostrato; diritti; disabili; disease; disponibili; disturbi; dolore; donne; dopo; dose; dosi; durante; durante il; durata; e del; e di; e il; e la; eandi; economiche; effects; effetto; efficace; elevata; endovenosa; esempio; essere; essi; et al; età; evidenti; famiglie; familiari; farmaco; farmeconomia; fase; fatto; figura; filipponi; fine; forme; fosfatasi; fratture; genere; genetiche; giorni; già; gli; grado; gravi; growth; gruppo; hanno; hormone; il neridronato; imperfetta; incremento; individui; infatti; inferiore; infusione; inibizione; inoltre; intermittente; intramuscolare; intravenous; j bone; lavoro; legame; linea; livello; loro; lungo; l’azione; l’efficacia; l’utilizzo; maggior; malattia; management; marker; massa; maturazione; med; mediante; medico; mentre; mesi; miglioramento; miner; minerale; minuti; modo; molto; momento; morbo; nascita; nei; nel; nel gruppo; nel trattamento; nelle; neridronato; nessuno; non; non è; normale; notevolmente; numero; ogni; orale; orfano; ossea; osteoblasti; osteoclastica; osteogenesis; osteoporosis; ottenuti; paget; parte; particolare; patients; patologia; pazienti; pediatrico; percentuale; percorsi; percorsi terapeutici; periodo; più; placebo; pochi; possibile; possibilità; possono; postmenopausal; precedentemente; precedenti; presentano; prestazioni; prima; processi; può; quali; qualità; quantità; quanto; quattro; quelle; questo; randomizzati; range; rapida; rara; reazione; relativi; res; rheumatoid; riassorbimento; ricevere; ricevuto; riduzione; rilevato; riportato; rischio; riservati; rispettivamente; rispetto; risultati; scheletriche; secondo; seed; seed tutti; sempre; senza; si è; sia; sierici; significativamente; significative; singola; sintesi; sito; situazione; soggetti; solo; somministrata; somministrazione; sono; soprattutto; sostanziale; sotto; spesso; stato; studio; sua; sulla; suo; tale; tali; telopeptide; terapeutici; terapia; terminale; termini; tessuto; therapy; tipi; tipo; totale; trattamento; trattamento dell’osteogenesi; trattati; treatment; trial; troppo; turnover; tutti; un farmaco; una; uno; urine; valori; valutare; variazioni; venga; vertebre; viene; vita; vitamina; vitro; vivo; women; zaniolo; è stato; è una cache: fe-795.pdf plain text: fe-795.txt item: #180 of 251 id: gjphm-146 author: Al-Tuma, Ali title: ADHERENCE TO METHOTREXATE IN IRAQI PATIENTS WITH RHEUMATOID ARTHRITIS : A CROSS-SECTIONAL STUDY date: 2022 words: 4477 flesch: 56 summary: Methotrexate (MTX) is the most widely used disease modifying anti-rheumatic drugs in the treatment of rheumatoid arthritis (RA). In RA, medication adherence is variable and sub-optimal. A cross sectional study was conducted at Rheumatology Clinic/Baghdad over a period from January-June 2020. It found that young age, middle-high educational level and good socio-economic state increase the regular MTX intake. keywords: activity; adherence; adherent; age; anti; arthritis; combination; criteria; data; difference; disease; dose; drug; duration; economic; effects; et al; factors; fear; gggggglo; global; group; health; improvement; intake; issue; joint; journal; lack; long; low; medicine; methotrexate; mode; mtx; non; oral; parenteral; patients; public; results; rheumatoid; rheumatoid arthritis; rheumatology; score; significant; studies; study; table; term; therapy; treatment; vol; years cache: gjphm-146.pdf plain text: gjphm-146.txt item: #181 of 251 id: gjphm-9 author: Mahmoud, Ziryab Imad Taha title: THE ROLE OF HYDROXYCHLOROQUINE AS MONOTHERAPY IN MANAGING EARLY UNDIFFERENTIATED ARTHRITIS: A PROSPECTIVE HOSPITAL-BASED STUDY date: 2019 words: 4844 flesch: 55 summary: Early undifferentiated arthritis (EUA) is a common form of arthritis with no definitive diagnosis. Female patients are more commonly affected than male ones. EUA is more common among middle aged people than other people. Most EUA patients are well responded to the hydroxychloroquine treatment. keywords: age; ale; analysis; arthritis; clinical; das28; diagnosis; disease; doi; duration; early; esr; eua; fem; female; gggggglo; global; group; hcq; health; high; hydroxychloroquine; issue; joint; joint pain; journal; khartoum; low; lupus; management; medicine; methotrexate; moderate; months; months treatment; multiple; multiple joint; nonsignificant; pain; patients; public; remission; response; rheumatoid; score; study; sudan; tender; tender multiple; treatment; undifferentiated; van; vol cache: gjphm-9.pdf plain text: gjphm-9.txt item: #182 of 251 id: iajs-1064 author: Shafeeq, Noorhan K. title: Glucagon-like Peptide-1 Levels and Related Parameters in Rheumatoid Arthritis Patients Prone to Atherosclerosis date: 2017 words: 4368 flesch: 61 summary: The study aimed to estimate the role of glucagon-like peptide-1 (GLP-1) and visfatin as a pro inflammatory marker in Rheumatoid Arthritis (RA) according to the activity of the disease. It found a significant increase in GLp-1 with CRP for RA patients and a significant decrease for the control group. keywords: 30مجلة; activity; aip; arthritis; atherosclerosis; blood; cardiac; cardiovascular; cell; chemistry; control; coronary; correlation; crp; differences; disease; effects; esr; et al; factor; function; glp‐1; glucagon; group; haitham; hdl; heart; ibn; important; increase; inflammation; inflammatory; insulin; jour; levels; like; marker; myocardial; pathogenesis; patients; peptide-1; protein; pure; ra patients; receptor; results; rheumatoid; rheumatoid arthritis; risk; role; sci; significant; studies; study; table; value; visfatin; vldl; vol; إبن; التھاب; الرثوي; الصرفة; المجلد; المفاصل; الھيثم; للعلوم; والتطبيقية cache: iajs-1064.pdf plain text: iajs-1064.txt item: #183 of 251 id: iajs-1920 author: Nazar, Lara Ali title: Study of IL-33 and IL-1R4 in Iraqi Rheumatoid Arthritis Female Patient's with and without Dyslipidemia Prone to Atherosclerosis date: 2019 words: 3903 flesch: 54 summary: Study of IL-33 and IL-1R4 in Iraqi Rheumatoid Arthritic Female Patient's with and without dyslipidemia Prone to Atherosclerosis. Results show an increase in ESR, RF, IL-3, and IL/IL/R4 levels and a decrease in the ratio between the two groups. keywords: appl.sci; arthritis; atherosclerosis; biomarker; cardiovascular; cell; clinical; control; correlation; cytokines; determination; disease; dyslipidemia; esr; factor; females; fibrosis; figure; groups; haitham; heart; https://doi.org/10.30526/32.1.1920; ibn; ihjpas; il-1r4; il-33; immune; inflammation; iraqi; journal; lee; levels; myocardial; pathway; patients; protein; pure; ratio; receptor; results; rheumatoid; rheumatoid arthritis; serum; significant; sst2; st2; st2l; study; system; test; treatment; type; vol; women cache: iajs-1920.pdf plain text: iajs-1920.txt item: #184 of 251 id: iajs-2010 author: Sultan, Nashwa S. title: Estimation of pentraxin-3(PTX3)in Rheumatoid arthritis males patients with (with and without) type II diabetes mellitus in Iraq date: 2018 words: 2979 flesch: 66 summary: Pentraxin-3(PTX3) is a protein that is structurally unrelated to the Pentraxin family. It is thought to play a role in rheumatoid arthritis, diabetes mellitus and asthma. The study found a significant increase in PTX3 levels in G1 and G2 compared to G3 and a significant decrease in G2. keywords: 0.001; acute; alkaline; alp; arthritis; chemistry; cities; crp; diabetes; different; dmп; groups; h.s; haitham; healthy; https://doi.org/10.30526/31.3.2010; ibn; ihjpas; increase; iraqi; jour; levels; males; patients; pentraxin; protein; ptx3; pure; ra patients; reactive; results; rheumatoid; sci; serum; significant; study; vol cache: iajs-2010.pdf plain text: iajs-2010.txt item: #185 of 251 id: iajs-2646 author: Jabbar, Enas Abdul Kareem title: Estimation of Some Biomarkers and Cholesterol / HDL Ratio to Predict the Risk of Cardiovascular Disease in Rheumatoid Arthritis date: 2021 words: 2611 flesch: 52 summary: There is a conference on cardiovascular disease at IHICCPASIH. 70 Iraqi patients newly diagnosed with rheumatoid arthritis (male and female) and 30 healthy served as control. The serum samples were taken to determine myocardial markers. The cholesterol/HDL ratio increased significantly in RA patients compared with healthy. keywords: age; ann; arthritis; cardiovascular; cardiovascular disease; cholesterol; conference; density; differences; disease; factors; groups; haitham; hdl; healthy; http://ihicps.com/; https://doi.org/; information; journal; levels; lipid; lipoprotein; markers; myocardial; patients; profiles; pure; ra patients; ratio; rheumatoid; rheumatoid arthritis; risk; science; study; total; websites cache: iajs-2646.pdf plain text: iajs-2646.txt item: #186 of 251 id: iajs-977 author: Hamad, N. S. title: Elevated Levels of Sialic Acid and Lipid-Associated Sialic Acid in Plasma of Rheumatoid Arthritis Patients date: 2017 words: 2768 flesch: 68 summary: Sialic acid is a marker of inflammation. It is used in the treatment of several diseases, including neuropathic and inflammatory diseases and certain tumours. It can also be a good marker for discriminating between non-malignant and malignant malignancies. keywords: acid; alhaitham; ared; arthritis; atients; comp; control; correlation; disease; glycoproteins; group; ibn; inflammation; lasma; levels; lip; lsa; n=40; normal; p<0.05; pure; r pure; reagent; resent; rheumatoid; room; sialic; solution; standard; temp; test; total; tsa; tubes; water cache: iajs-977.pdf plain text: iajs-977.txt item: #187 of 251 id: ijmr-10671 author: Zarudna, O. I. title: CONNECTIVE TISSUE DISEASES: FOCUS ON MICROCIRCULATORY BED date: 2020 words: 4632 flesch: 55 summary: Microcirculation is a target, source and reason of the pathological process in people with connective tissue diseases. The study focused on biopsy material of skin flaps harvested from patients’ fingers to identify specific morphological changes. Most patients involved suffered from abnormal peripheral hemodynamics. Kidneys, lungs or heart were damaged more frequently in the patients with peripheral blood circulation disorders. keywords: activity; analysis; arthritis; bed; biopsy; blood; blood circulation; bloodstream; capillaries; cases; changes; circulation; clinical; concentration; connective; damage; data; decrease; degree; difference; disease; disorders; doi; duration; endothelial; erythematosus; flaps; flow; group; hemocapillaries; hemodynamics; high; horbachevsky; ijmmr; indices; issn; issue; legs; lupus; material; medical; microcirculatory; morphological; n=10; nailfold; national; normal; number; o.i; ohm; pathological; patients; peripheral; peripheral blood; process; research; results; rheovasography; rheumatoid; sclerosis; significant; skin; sle; ssc; study; systemic; systolic; table; ternopil; university; vascular; vol; yrs; zarudna; ет1 cache: ijmr-10671.pdf plain text: ijmr-10671.txt item: #188 of 251 id: iqjmc-1101 author: Manhal, Falah S. title: Cytokine Profile in Patients with Rheumatoid Arthritis date: 2010 words: 2848 flesch: 54 summary: The cytokine serum levels were measured by EASIA in sera from 50 RA patients and 40 healthy donors. IL-2, IL-6, IFN-δ and TNF-α levels were elevated in serum samples of RA patients compared with apparently healthy controls. keywords: activity; age; alpha; arthritis; baghdad; biosource; chronic; clinical; control; cytokine; differences; disease; easia; factor; groups; healthy; ifn; il-2; il-6; inflammation; inflammatory; interval; levels; mean; med; necrosis; patients; ra1; reference; results; rheumatoid; rheumatoid arthritis; role; sera; serum; significant; study; table; test; tnf cache: iqjmc-1101.pdf plain text: iqjmc-1101.txt item: #189 of 251 id: iqjmc-1174 author: Saleh, Shahlaa M. title: Proinflammatory cytokines profile in patients with Rheumatoid arthritis date: 2009 words: 1342 flesch: 42 summary: Rheumatoid arthritis is a chronic, inflammatory autoimmune disorder that causes the immune system to attack the joints. Shahlaa M.Saleh, PhD, Jabbar R. Zangor, PhD and 50 patients with a diagnosis of RA had positive test results between January 2008 and May 2009. Results showed a significant increase in TNF-alpha, IL-1 beta and GM-CSF in patients with RA. keywords: arthritis; control; csf; cytokines; destruction; disease; group; il-1; important; inflammation; inflammatory; joints; levels; patients; results; rheumatoid; role; serum; study; tnf cache: iqjmc-1174.pdf plain text: iqjmc-1174.txt item: #190 of 251 id: iqjmc-1211 author: Al-Marsomi, Huda Th. title: Adenosine Deaminase (ADA) in Rheumatoid Arthritis in patients (RA) date: 2009 words: 1139 flesch: 52 summary: Adenosine deaminase (ADA) is an indicator of the proliferation and differencing of lymphocytes. ADA is lower in RA patients than in the control group. ADA may be due to the predominance of CD4+ T cells in the peripheral blood. keywords: ada; adenosine; arthritis; cd4; cell; clinical; control; deaminase; disease; group; immune; level; lymphocyte; med; patients; proliferation; results; rheumatoid; role; serum cache: iqjmc-1211.pdf plain text: iqjmc-1211.txt item: #191 of 251 id: iqjmc-1288 author: Abbas, Nahida R. title: Correlation between some immunological parameters and clinical presentation in RA patients date: 2008 words: 2105 flesch: 56 summary: Nahida Abbas, Eman, Samira, Ali, Obeidy, Al-Naim, Ali Kadim, and Samira studied the correlation between C, CRP, IgM, IgG, IgA, SRI A, and some clinical presentation in 74 patients with Rheumatoid Arthritritis. keywords: activation; ali; arthritis; baghdad; clinical; complement; control; correlation; criteria; crp; eman; fac; healthy; iga; igg; igm; immunological; joint; level; mean; med; nahida; parameters; patients; presentation; range; rheumatoid; samira; serum; significant; sle; swelling; table cache: iqjmc-1288.pdf plain text: iqjmc-1288.txt item: #192 of 251 id: iqjmc-1384 author: Thanoon, Imad A. title: Oxidative Stress & C – Reactive Protein In Patients With Arthritis date: 2007 words: 3669 flesch: 53 summary: Oxidative damage has been suggested to play a key role in the pathogenesis of rheumatoid arthritis (RA) and osteoarthritis (OA). Many studies had shown that those patients have low antioxidants level and are at risk of increased oxidative stress. Serum TAS, MDA and CRP levels were measured in 16 RA and 24 OA patients and compared with those obtained from 25 healthy controls. TAS was significantly lower in RA group than in the OA and control groups. MDA, CRP and age were significant negative correlations between TAS and MDA. keywords: activity; age; antioxidant; arthritis; baghdad; cartilage; college; control; correlation; crp; damage; disease; fac; free; group; healthy; higher; increase; index; inflammation; inflammatory; introduction; joint; lecturer; levels; lipid; lower; malondialdehyde; marker; mda; mean; med; mosul; oa patients; osteoarthritis; oxidative; oxidative stress; pathogenesis; patients; peroxidation; protein; ra patients; rate; reactive; results; rheumatoid; role; serum; significant; status; stress; studies; study; subjects; tas; total; university; vitamin; vol cache: iqjmc-1384.pdf plain text: iqjmc-1384.txt item: #193 of 251 id: iqjmc-1389 author: Al-Haidary, Batool A. title: Possible Role of Interleukin-6 in Rheumatoid Arthritis date: 2007 words: 2631 flesch: 54 summary: Interleukin-6 plays a key role in the autoimmune disease Rheumatoid arthritis. The IL-6 concentration in the sera of 75 RA patients has been estimated using an ELISA technique. For most RA patients with high levels, HLA-DR4 was found to be present. keywords: activity; arthritis; baghdad; cells; college; comparison; concentration; controls; correlation; damage; disease; dr4; factor; figure; groups; haidary; healthy; high; hla; il-1; il-6; inflammatory; interleukin-6; introduction; level; med; observed; oxidative; patients; ra patients; results; rheumatoid; rheumatoid arthritis; role; sera; serum; stress; studies; study; synovial; vol cache: iqjmc-1389.pdf plain text: iqjmc-1389.txt item: #194 of 251 id: iqjmc-1476 author: Abbas, Nahida R. title: Rheumatiod Factor isotype in Rheumatiod Arthritis patients . date: 2007 words: 1478 flesch: 64 summary: Rheumatoid arthritis (RA) is a systemic inflammatory disease that affects synovial membrane of diarthridal joints. RF is a form of IgA, IgG, IgM, IgA or IgG isotype found in 74 patients with RA. keywords: arthritis; baghdad; elisa; factor; iga; igg; igm; isotypes; latex; mean; median; negative; patients; positive; range; rheumatoid; studies; table cache: iqjmc-1476.pdf plain text: iqjmc-1476.txt item: #195 of 251 id: iqjmc-1503 author: Abbas, Nahida R. title: Some Immunological Profile of Rheumatoid Arthritis date: 2006 words: 2116 flesch: 63 summary: Seventy-four cases of Rheumatoid Arthritis (RA), fifty cases of systemic Lupus erythematosus (SLE), and thirty healthy normal controls were investigated for detection of RF, total serum immunoglobulins (Igs), antinuclear antibody (ANA), and anti-double stranded DNA (anti-ds DNA). RA showed 58.1% positive for RF, SLE showed 14% positivity in SLE and 6.6% in normal individuals. keywords: age; ana; antibodies; arthritis; baghdad; concentration; control; criteria; difference; dna; groups; healthy; iga; igg; igm; igs; level; mean; medicine; patients; positive; range; rheumatoid; sera; serum; sle; studies; study; table; total cache: iqjmc-1503.pdf plain text: iqjmc-1503.txt item: #196 of 251 id: iqjmc-1677 author: mad, Talal Abdulsa title: Serum Lipids in Patients with Active Rheumatoid Arthritis And It's Relation to Drug Therapy date: 2005 words: 75 flesch: -49 summary: Simpo PDF Merge and Split Unregistered Version is available at: http://www.simpopdf.com, and it is available as a PDF and as a split unregistered version. It is available in English and in German. keywords: pdf cache: iqjmc-1677.pdf plain text: iqjmc-1677.txt item: #197 of 251 id: iqjmc-1686 author: Al- Mousawy, khalidda title: possible protective role of interleukin-4 in rheumatoid arthritis date: 2005 words: 24 flesch: 13 summary: Simpo PDF Merge and Split Unregistered Version - http://www.simpopdf.com/simpo/simpopdf-merge-splich-unregistered-v2.html is available. It's a merge and unregistered version. keywords: simpo cache: iqjmc-1686.pdf plain text: iqjmc-1686.txt item: #198 of 251 id: iqjmc-860 author: Alosami, Mohammed H. title: The Role of Resistin in Patients with Primary Fibromyalgia date: 2011 words: 2795 flesch: 55 summary: Mohammed H. Alosami and his team studied the role of resistin in the pathogenesis of Fibromyalgia syndrome (FMS). They found that resistin concentration was higher in FMS patients than in the control group. They also found that it was positively correlated with waist circumference and age. keywords: abdominal; adipocytes; adipose; age; alosami; arthritis; baghdad; blood; bmi; cells; circumference; concentration; controls; correlation; criteria; diabetes; expression; fac; females; fibromyalgia; figure; fms; group; healthy; human; insulin; level; like; males; mean; med; mohammed; obesity; pain; patients; positive; primary; resistin; rheumatoid; role; serum; sex; significant; study; syndrome; tissue; waist; wcr; years cache: iqjmc-860.pdf plain text: iqjmc-860.txt item: #199 of 251 id: iqjmc-976 author: Al-Hassan, Ahmed A. H. title: Role of Pro- and Anti-Inflammatory Cytokines in Rheumatoid Arthritis: Correlation with Disease Activity. date: 2010 words: 3208 flesch: 59 summary: Ahmed A. H. Al-Hassan and his colleagues studied the role of pro- and anti-inflammatory cytokines in Rheumatoid arthritis. They found a positive correlation between the levels of IL-1A, IL-2, IL-6, I-LIL-8, I-IL-12 and TNF-A and activity of the disease. keywords: active; activity; ahmed; anti; arax; arthritis; baghdad; control; correlation; cytokines; disease; fac; hassan; healthy; iara; ifn; il-12; il-4; il-6; il-8; inactive; inflammation; inflammatory; inflammatory cytokines; levels; mann; maximum; median; minimum; p<0.01; patients; pro; proand; production; rheumatoid; rheumatoid arthritis; role; serum; study; tnf; whitney cache: iqjmc-976.pdf plain text: iqjmc-976.txt item: #200 of 251 id: jbcd-1748 author: Hamed, Munir Nasr title: Serum Level of TNF-α and IL-17 in Patient Have Chronic Periodontitis Associated Rheumatoid Arthritis date: 2017 words: 4279 flesch: 56 summary: There is growing evidence that chronic periodontitis and rheumatoid arthritis share many pathological features. The current study shows a positive correlation between serum levels of IL-17 and TNF-α and the number of missing teeth in the current study. It also shows a higher rate of gingival inflammation and bleeding on probing. keywords: 0.001; 29(1; alpha; arthritis; attachment; bagh; bleeding; bop; chronic; clinical; college; control; correlation; cytokines; dentistry; destruction; differences; disease; factor; gingival; group; high; higher; il-17; immune; immunological; index; inflammatory; level; march; maxillofacial; mean; missing; n=30; necrosis; number; oral; parameters; patients; periodontal; periodontitis; plaque; pli; ppd; pra; probing; range; rheumatoid; role; serum; significant; study; subjects; surgery; table; teeth; test; tnf; tumor; value; vol; الرثوي; الفا; اللثة; المزمن; مؤشر cache: jbcd-1748.pdf plain text: jbcd-1748.txt item: #201 of 251 id: jbcd-201 author: Khidhir, Raya M title: The study of tempromandibular joint disorders and anti-cyclic citrullinated peptide antibodies in serum and saliva of patients with rheumatoid arthritis date: 2014 words: 2821 flesch: 46 summary: Raja F. Khidhir, B.S., Raja H. Al-Jubouri, M.Sc., Ph.D., and Raya M. Khidsir studied the relationship between tempromandibular joint disorders and anti-cyclic citrullinated peptide antibodies in serum and saliva of patients with rheumatoid arthritis. keywords: 25(special; anti; antibodies; anticcp; arthritis; bagh; ccp; chronic; clinical; college; controls; cyclic; dentistry; diagnosis; disease; disorders; findings; frequency; groups; healthy; involvement; issue; joint; muscle; negative; non; oral; patients; peptide; positive; prevalence; ra patients; results; rheumatoid; serum; serum anti; significant; sounds; study; tempromandibular; tenderness; tmj cache: jbcd-201.pdf plain text: jbcd-201.txt item: #202 of 251 id: jbcd-531 author: Abdul Qadir, Maisaa I title: Salivary C- reactive protein in relation to periodontal health among a group of patients with rheumatoid arthritis in Iraq date: 2014 words: 4360 flesch: 51 summary: Maisaa Abdul Qadir, B.D.S, H.S., Athraa M. Al-Waheb, M.Sc. and J. Bagh College Dentistry studied salivary C-reactive protein in relation to periodontal health among a group of patients with rheumatoid arthritis in Iraq. keywords: activity; age; arthritis; bagh; body; cases; chronic; clinical; coefficient; college; community; controls; correlation; count; cpi; crp; dentistry; difference; disease; effect; etanercept; gingival; groups; health; higher; highest; index; inflammatory; levels; lowest; mean; median; methotrexate; mg/1; mtx; n=25; oral; orthodontics; patients; pedodontics; periodontal; periodontitis; plaque; preventive; protein; ra cases; range; rank; reactive; results; rheumatoid; salivary; samples; score; september; serum; sextants; significant; statistical; study; systemic; table; treatment; value; vol cache: jbcd-531.pdf plain text: jbcd-531.txt item: #203 of 251 id: jfsk-4746 author: Djunarko, Ipang title: Identification Bioactive Compound of Ethanol-Water Fraction of Coleus atropurpureus for Anti-rheumatic Rheumatism in CFA-induced Rats date: 2022 words: 5301 flesch: 54 summary: Coleus atropurpureus did not act as an anti-rheumatic arthritis agent in CFA-induced rats. Nonsteroidal anti-inflammatory drugs are used for pain and to slow the progression of rheumatoid arthritis. keywords: 2022; activity; adjuvant; anti; arthritis; article; atropurpureus; bioactive; cfa; ch2; ch3; changes; clinical; coleus; community; complete; compound; control; diclofenac; different; djunarko; effect; et al; ethanol; ewc; figure; forskolin; fraction; freund; ftir; group; hexane; identification; indonesia; inflammation; inflammatory; isolated; journal; leaves; low; nmr; pain; pharmaceutical; pharmacy; rats; research; rheumatoid; sciences; scores; secondary; singh; spectrum; study; table; test; treatment; university; water; weight cache: jfsk-4746.pdf plain text: jfsk-4746.txt item: #204 of 251 id: jidhealth-60 author: Choudhari, Omkar Kalidasrao title: Cotrimoxazole as adjuvant therapy in critical ill COVID 19 patients date: 2020 words: 1048 flesch: 44 summary: Cotrimoxazole can be used as an adjuvant therapy in critical ill COVID-19 patients. It is an antibiotic with anti-inflammatory and immunomodulatory properties. It has some side effects, but is well-tolerated among the population. keywords: activation; article; author(s; available; cells; commons; cotrimoxazole; covid-19; creative; data; delhi; drugs; factor; hiv; immune; inflammatory; journal; license; necrosis; new; patients; respiratory; tnf; treatment; tumour; use cache: jidhealth-60.pdf plain text: jidhealth-60.txt item: #205 of 251 id: jiimc-1001 author: Syed Salman Naeem Gilani , Muhammad Naeem , Tauseef Bukhari , Muhammad Asad Ullah title: CASE REPORT: Effects of Autologous Bone Marrow Derived Stem Cell Transplant and Exercise Training Program on Rheumatoid Arthritis date: 2017 words: 1909 flesch: 59 summary: A 65-year-old female patient from Rawalpindi was diagnosed with Rheumatoid Arthritis. She was treated with autologous bone marrow derived stem cell transplantation and exercise training. After one year of treatment, the patient had improvement in all the signs and symptoms. keywords: arthritis; autologous; bone; case; cell; csf; difficulty; disease; effects; exercise; grip; hospital; improvement; joints; marrow; motion; multiple; muscle; pain; patients; power; procedure; range; rheumatoid; severe; stem; study; symptoms; table; therapy; training; transplant; transplantation; treatment; use; weeks; year cache: jiimc-1001.pdf plain text: jiimc-1001.txt item: #206 of 251 id: jiimc-1008 author: Maria Shafiq , Ayesha Noor , Amer Siddiq title: Frequency of Red Cell Alloantibodies in Pregnant Women of North West Pakistan date: 2017 words: 3297 flesch: 61 summary: The study was conducted in one year November 2012 to October 2013 at the Haematology Department, Army Medical College, National University of Sciences and Technology (NUST) in collaboration with Department of Gynaecology and Obstetrics, Military Hospital, Rawalpindi. A total of 600 samples were studied. The frequency of alloantibodies in pregnant women in this study was 0.5% (3/600). Prevalence of immunization specifically in Rh-negative blood group was 5.5%. Rh D antibodies are the only frequent antibodies in majority of pregnant women with Rh negative blood group. keywords: age; alloantibodies; alloimmunization; antenatal; anti; antibody; antigen; association; blood; blood group; case; cell; cell alloantibodies; college; countries; department; disease; females; frequency; group; guidelines; haematology; haemolytic; history; jiimc; maternal; med; medical; multigravida; negative; newborn; no.4; obstetric; page; pakistan; phenotype; positive; pregnancy; pregnant; prevalence; primigravida; red; red cell; risk; samples; screening; significant; studies; study; table; test; transfus; transfusion; variables; vol; women cache: jiimc-1008.pdf plain text: jiimc-1008.txt item: #207 of 251 id: jiimc-1186 author: Naseeb ur Rehman Shah , Mohammad Sajjad Khattak , Sami Ullah , Asim Muhammad title: Dyslipidemia Among Patients of Rheumatoid Arthritis date: 2021 words: 2763 flesch: 59 summary: Dyslipidemia was present in 48% of Rheumatoid Arthritis patients, whereas 74% of those who didn't have it were not at risk of cardiovascular diseases. Early diagnosis and treatment is mandatory to reduce morbidity and mortality. keywords: age; arthritis; atherosclerosis; bannu; blood; cardiovascular; cases; cholesterol; common; criteria; cvd; density; department; diagnosis; different; diseases; duration; dyslipidemia; female; frequency; general; group; hdl; high; inflammation; inflammatory; ldl; level; lipids; lipoprotein; male; mean; patients; ratio; rheumatoid; rheumatoid arthritis; risk; study; table; total; treatment; years cache: jiimc-1186.pdf plain text: jiimc-1186.txt item: #208 of 251 id: jiimc-1621 author: Dr. Prashant Kaushik title: Editorial: Rheuminations date: 2022 words: 1712 flesch: 66 summary: Prashant Kaushik and Aarya A.Kaushik have been in medicine for 35+ years. Rheumatology was recognized as a subspecialty of medicine only in 1972. Biologics with disease modifying anti-rheumatic drugs (b-DMARDs) were approved by FDA in 1998. They are effective but expensive. keywords: adherence; cell; changes; coronary; dec; diabetes; diet; disease; dmards; doi; epub; erratum; feb; heart; immune; intervention; jama; kaushik; lifestyle; loss; mbbs; medicine; pmid; prashant; randomized; remission; rheumatic; rheumatology; systemic; treatment; trial; type; weight cache: jiimc-1621.pdf plain text: jiimc-1621.txt item: #209 of 251 id: jiimc-764 author: Syed Qasim Mehmood, Johar Ali, Asif Saeed, Muhammad Nawaz, Rifat Latif title: Efficacy of Intrasheath Steroid Injection in Treating De Quervain's Disease date: 2012 words: 2177 flesch: 64 summary: There was an observational study on the effectiveness of intrasheath steroid injection in treating de Quervain's disease. It was carried out at BBS Teaching Hospital Abbottabad from April 2006 to September 2009. Eighty patients were given injections of 40 mg Methyl Prednisolone mixed with one ml of lignocaine 2% in the first dorsal compartment of the wrist. 90% of them were cured and 75% required only one injection. Only two of them underwent surgical release. keywords: cases; compartment; complications; cured; de quervain; department; disease; dorsal; effective; efficacy; group; hand; hospital; injection; intrasheath; orthopedics; outpatient; pain; patients; quervain; radial; release; second; severe; steroid; study; subcutaneous; surg; surgical; tendon; tenosynovitis; tissue; treatment; weeks; women; wrist cache: jiimc-764.pdf plain text: jiimc-764.txt item: #210 of 251 id: jiimc-925 author: Asim Zulfiqar title: Editorial: Early Diagnoses of Rheumatoid Arthritis is Important. It should be Clinical not Lab Dependent date: 2016 words: 942 flesch: 48 summary: Asim Zulfiqar is a professor of medicine at Riphah International Medical College in Islamabad. He wrote an article for JIIMC on the early diagnosis of rheumatoid arthritis. It was accepted on March 6, 2016. keywords: american; arthritis; classification; clinical; criteria; diagnosis; disability; disease; duration; early; era; important; joint; medicine; patients; rheumatoid; serological; table; therapeutic cache: jiimc-925.pdf plain text: jiimc-925.txt item: #211 of 251 id: jiimc-926 author: Bushra Gohar Shah , Asma Saeed , Mohammad Faisal Khan , Hamid Javaid Quershi title: Diagnostic Usefulness of Anti-Cyclic Citrullinated Peptide and Anti-Mutated Citrullinated Vimentin Antibodies in the Diagnosis of Seronegative Rheumatoid Arthritis Patients date: 2016 words: 2952 flesch: 53 summary: The study was conducted over a year from January 2010 to December 2010 at the University of Health Sciences, Lahore. 58 patients with rheumatoid arthritis fulfilling the American College of Rheumatology (ACR) Criteria were included in the study. A CCP antibody was positive in 9 out of 28 RF-ive patients. A MCV antibody was present in 11 out of 14 RF-veterans. The sensitivity of aMCV antibody in RF-vulnerable group was 39.2%. keywords: accp; amcv; anti; antibodies; antibody; arthritis; ccp; citrullinatedvimentin; college; criteria; cyclic; department; diagnosis; disease; early; elisa; factor; group; jiimc; joint; lahore; marker; mcv; mutated; no.1; patients; peptide; physiology; positive; present; research; results; rheumatoid; rheumatoid arthritis; rheumatology; sensitivity; seronegative; serum; study; subjects; value; vol cache: jiimc-926.pdf plain text: jiimc-926.txt item: #212 of 251 id: jscs-2910 author: Živanović Radnić, Tatjana title: Alfacalcidol modulates oxidative stress parameters in the peripheral blood of patients with active rheumatoid arthritis date: 2016 words: 6834 flesch: 53 summary: Alfacalcidol modulates oxidative stress parameters in the peripheral blood of patients with active rheumatoid arthritis. It also changed the response of RA patients’ PBMC to stimulation preventing the O2-production and mitochondrial membrane depolarisation. The activity of GPx was significantly lower in RA patients before treatment and after. keywords: 25(oh)d; acid; active; activity; adobe; aldrich; alfacalcidol; alfacalcidol therapy; alfacalcidol treatment; antioxidant; arthritis; assay; available; belgrade; biochem; blood; calcium; cat; cells; cimen; clinical; concentration; controls; das28; data; disease; effect; enzymes; erythrocytes; false; fluorescence; form; ghb; glutathione; gpx; group; gsh; h2o2; healthy; higher; hormone; improvement; increase; int; inter; intra; levels; line; long; lower; mda; membrane; mitochondrial; oxidative; parameters; patients; pbmc; pdf; peripheral; potential; production; ra patients; radnić; results; rheumatoid; rights; role; ros; scs; serbia; serum; sigma; significant; sod; stimulated; stimulation; stress; study; superoxide; table; therapy; treatment; true; values; vitamin; w12; weeks; www.shd.org.rs/jscs/; živanović; болесника; значајно; ниво cache: jscs-2910.pdf plain text: jscs-2910.txt item: #213 of 251 id: medicina-285 author: Bastiana, Yefta Daniel title: Effect of range of motion and isometric strengthening exercises on grip strength and hand function in rheumatoid arthritis patients date: 2008 words: 5373 flesch: 80 summary: Yefta Daniel Bastiana, Angela BM Tulaar, Surjanto Hartono, Zuljasri Albar and Dr Yefta are authors of a study on the effect of range of motion and musclestrengthening exercises for 6 weeks on grip strength and hand function in chronic rheumatoid arthritis patients. keywords: arthritis; c e; c t; control; disease; e d; e e; e l; e n; e s; exercises; function; grip; group; h e; hand; intervention; joint; m e; muscle; n c; n d; n g; n s; n t; o n; patients; r e; rheumatoid; rom; significant; strength; strengthening; study; subjects; t e; t h; t r; t s; table; weeks cache: medicina-285.pdf plain text: medicina-285.txt item: #214 of 251 id: mkg-1083 author: Suardita, Ketut title: The potential application of stem cell in dentistry date: 2006 words: 3230 flesch: 50 summary: Ketut Suardita is a professor at the Department of Conservative Dentistry at Airlangga University in Surabaya, Indonesia. Stem cells were found in dental pulp, periodontal ligament, and alveolar bone marrow. In medical therapy, stem cells have been used for engineering many tissues and organs. It is possible that the dentist could use stem cells to regenerate lost or damaged teeth and periodontals. keywords: adult; adult stem; alveolar; application; autologous; bone; capacity; cartilage; cells; complex; damage; defects; dental; dentin; dentistry; differentiate; diseases; embryonic; embryonic stem; engineering; gigi; graft; gronthos; human; injury; isolated; ligament; marrow; medical; mesenchymal; mesenchymal stem; mscs; multipotent; muscle; new; organs; periodontal; potential; present; pulp; pulp stem; regeneration; renewal; repair; research; robey; shi; stem; stem cells; structures; technique; teeth; therapy; tissues; tooth; transplantation; transplanted; treatment; types; use cache: mkg-1083.pdf plain text: mkg-1083.txt item: #215 of 251 id: ojphi-9695 author: Ho, Yenling A. title: Accuracy of ICD Codes for Identification: Review of Chlamydia, Gonorrhea and Syphilis date: 2019 words: 1191 flesch: 41 summary: Yenling Ho, Saurabh Rahurkar, Janet Arno, Brian E. Dixon, Marion County Public Health Department, Indianapolis, Indiana, United States, and Roudebush VA Medical Center, Indianapolis. The purpose of this study is to review the literature for evidence on the validity of ICD-9-CM and -10-CM codes for the purpose of identifying chlamydia, gonorrhea and syphilis. keywords: administrative; articles; cases; chlamydia; codes; conference; data; gonorrhea; health; indiana; indianapolis; isds; pid; public; pubmed; review; states; stis; studies; syphilis; united; validity cache: ojphi-9695.pdf plain text: ojphi-9695.txt item: #216 of 251 id: panacea-1099 author: Kumar, Banna Kiran title: A clinical study of surgical management of tendoachilles rupture by various modalities date: 2021 words: 2434 flesch: 61 summary: Panacea Journal of Medical Sciences 2021;11(3):401-405. Most Indians use Indian squatting type of toilets which is common cause of open injury to Achilles tendon. Achilles tendon ruptures are more common in males. Raghuram ram technique is safe and good method for chronic ruptures. keywords: achilles; achilles tendon; activities; acute; cases; chronic; clinical; common; daily; flexion; foot; functional; gap; good; healing; injury; journal; kumar; limitations; management; medical; moderate; operative; outcome; pain; panacea; patients; percentage; plantar; post; raghuram; recreational; repair; results; rupture; sciences; score; study; surgery; surgical; table; technique; tendon; weeks; wound cache: panacea-1099.pdf plain text: panacea-1099.txt item: #217 of 251 id: panacea-536 author: Surendran, P K title: Serological profile of rheumatoid arthritis in a tertiary care hospital date: 2018 words: 2235 flesch: 47 summary: P.K Surendran is an assistant professor at P.K Das Institute of Medical Science, Vaniyamkularn, Kerala, India. 150 patients with Rheumatoid Arthritis were included in the prospective study carried out over a period of one year in a tertiary care teaching hospital between January 2017 and December 2017. 120 females and 30 males were included with a M:F ratio of 1:4. keywords: age; anti; antibodies; anti‐ccp; arthritis; cases; ccp; classification; clinical; combination; criteria; crp; diagnosis; disease; early; esr; factor; females; igm; inflammatory; journal; latex; medical; patients; positive; present; quantitative; results; rheumatoid; rheumatoid arthritis; sensitivity; serological; specificity; study; table; tests; total; years cache: panacea-536.pdf plain text: panacea-536.txt item: #218 of 251 id: panacea-878 author: ., Sharanayya title: Joint involvement in Rheumatoid arthritis: Sonographic evaluation in comparison with Radiography date: 2021 words: 3617 flesch: 52 summary: Sharanayya, Shamrendra Narayan, Vandana Verma, Madhu Sharma, Anjana Pande, Vivek Jirankali, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, and Sarojini Naidu Medical College, Agra, India. 55 patients with Rheumatoid Arthritis underwent ultrasound and radiographic examination of wrist and hand. keywords: advanced; advanced ra; agreement; arthritis; articular; carpi; cartilage; cases; changes; comparison; detection; disease; doi:10.1002; doppler; early; early ra; early rheumatoid; effusion; erosions; erosive; evaluation; examination; extensor; findings; flexor; group; hand; hypertrophy; imaging; inter; intra; involvement; joint; journal; medical; modality; osteophytes; panacea; patients; power; radiography; reduced; rheumatoid; rheumatoid arthritis; rheumatology; sciences; sharanayya; sonographic; study; subjects; synovial; table; tendon; tenosynovitis; thickness; total; ultrasonography; ultrasound; wrist cache: panacea-878.pdf plain text: panacea-878.txt item: #219 of 251 id: pjo-354 author: Harris Iqbal, Sameera Irfan, title: Role of Topical Cyclosporin in Scleritis: A Case Series date: 2018 words: 2791 flesch: 48 summary: Sameera Irfan, Harris Iqbal and Sameera. Irfan report on a series of cases of anterior, non-necrotizing scleritis that were effectively treated with topical 0.075% - 1% cyclosporine A and followed-up for a year. keywords: anterior; apr; associated; cases; clinical; cyclosporine; diffuse; disease; drops; effects; eye; foster; immune; improvement; inflammation; inflammatory; irfan; journal; jun; lahore; mild; moderate; months; necrotizing; nodular; ocular; ophthalmology; pakistan; patients; posterior; response; scleral; scleritis; score; series; severe; study; systemic; table; therapeutic; therapy; topical; treatment; vol; weeks; years cache: pjo-354.pdf plain text: pjo-354.txt item: #220 of 251 id: pjo-843 author: S. Biswas, H.P. Adhikary, Qasim Mansoor, Roa Rashad Qamar, title: Long-Term Follow-up of Corneal and Sclero-Corneal Grafting in Severe Eye Perforations date: 2006 words: 2708 flesch: 52 summary: Qasim Mansoor, Roa Rashad Qamar, S. Biswas, H.P. Adhikary, and others studied the long-term follow-up of corneal and sclero-corneal grafts for perforated eyeballs over a period of 15 years. All the patients were able to keep their eyes with a variable amount of vision, except one patient who died after 4 months. keywords: anterior; arthritis; associated; cases; cataract; chronic; conditions; corneal; corneal graft; corneo; donor; eye; eyeballs; eyes; fig; follow; free; globe; graft; grafting; group; hand; keratoplasty; melt; months; ophthalmology; pathological; patients; perforated; perforation; procedures; reconstruction; results; rheumatoid; risk; scleral; segment; syndrome; tissue; trauma; ulcer; vision; years cache: pjo-843.pdf plain text: pjo-843.txt item: #221 of 251 id: pjohns-753 author: Cevallos-Schnabel, Filipina T. title: An Easy Guide for Voice Evaluation in the Clinic date: 2008 words: 1910 flesch: 53 summary: Filipina T. Cevallos-Schnabel, MD, is an otolaryngologist. PhiliPPine Journal of Otolarynology-head and neck Surgery, Vol. 23 no. 2 July – december 2008, no. 52. The most common complaint is change in the quality of the voice or hoarseness. keywords: advantages; cause; changes; clin; common; deviance; diagnosis; disorders; dysphonia; edema; evaluation; examination; fold; head; high; history; hoarseness; important; journal; laryngeal; limitations; medical; neck; nodules; otolaryngology; pain; paralysis; patient; philippine; pitch; problems; quality; reflux; suggestive; surgery; tension; throat; thyroid; vocal; voice cache: pjohns-753.pdf plain text: pjohns-753.txt item: #222 of 251 id: pmmb-661 author: Vairavan, Kirttna Solai title: Exploring the Safety and Effects of COVID-19 Vaccination in Patients with Autoimmune Disease date: 2022 words: 7533 flesch: 57 summary: The COVID-19 pandemic is caused by severe-respiratory-coronavirus (SARS-V-11). Vaccines are our most effective line of defense against the rapidly spreading and mutating virion. There is significant vaccine hesitancy among those with autoimmune conditions who fear the vaccine may cause them more harm than good. keywords: a0000277; adverse; anti; antibody; arthritis; autoimmune; autoimmune patients; biologics; biology; bnt162b2; booster; case; cell; cohort; conditions; controls; coronavac; covid-19; covid-19 vaccination; covid-19 vaccine; days; different; disease; dose; effects; erythematosus; et al; exacerbation; flares; gravis; group; healthy; herpes; immunogenicity; inactivated; inflammatory; inhibitors; law; lupus; malaysia; medicine; methotrexate; microbes; molecular; mrna; mrna vaccine; myasthenia; new; non; old; onset; outcomes; pain; participants; patients; pmmb; population; post; progress; psoriasis; psoriatic; reported; response; review; rheumatoid; rheumatology; risk; rituximab; safety; sars; search; second; series; severe; sle; studies; study; symptoms; systemic; table; tan; treatment; vaccinated; vaccination; vaccine; vector; viral; year; zoster cache: pmmb-661.pdf plain text: pmmb-661.txt item: #223 of 251 id: roneurosurgery-913 author: Saba, N. title: Fusion of axis with third cervical vertebra: A case report date: 2016 words: 1907 flesch: 45 summary: Saba et al found a fusion of the axis with the third cervical vertebrae in a case report from King George’s Medical University, Lucknow-226003, Uttar Pradesh, India. It is a rare condition with an incidence of 0.4% to 0.7% with no sex predilection. The finding is noteworthy to neurosurgeons and radiologists. keywords: 3rd; anomaly; anterior; articular; aspects; associated; axis; body; case; cervical; clinical; condition; congenital; features; feil; foramen; fusion; george; india; journal; king; klippel; medical; pedicles; posterior; pradesh; report; segmentation; spinal; syndrome; trauma; university; uttar; vertebrae cache: roneurosurgery-913.pdf plain text: roneurosurgery-913.txt item: #224 of 251 id: safpj-4446 author: Ally, Mahmood M.T.M. title: Rheumatoid Arthritis date: 2016 words: 4143 flesch: 39 summary: Rheumatoid arthritis (RA) is an immune-mediated inflammatory disorder. Therapies targeting specific molecular and cellular components of the inflammatory response are being used to treat RA and other autoimmune-mediated diseases. Genetic factors play an important role in disease susceptibility. keywords: acpa; activity; african; anti; antigens; appropriate; arthritis; associated; bibliographic; bone; cells; cellular; changes; chronic; clinical; components; connective; control; criteria; crp; cytokines; diagnosis; disease; disorders; dmards; drugs; duration; early; effects; esr; factor; features; footer; health; hepatitis; immune; important; inflammation; inflammatory; involvement; joint; low; management; measures; mechanisms; methotrexate; normal; number; page; patients; positive; practice; presence; progression; referencingwww.tandfonline.com/oemd; response; results; review; rheumatoid; rheumatoid arthritis; rheumatology; role; similar; south; specific; systemic; therapies; therapy; tissue; use cache: safpj-4446.pdf plain text: safpj-4446.txt item: #225 of 251 id: safpj-4595 author: Harmse, Leonie title: An overview of the biological disease modifying drugs available for arthritic conditions in South Africa date: 2016 words: 3197 flesch: 35 summary: Biological DMARDs have been proven to be efficacious against the progression of rheumatoid arthritis (RA) when there is no response or a poor response to traditional DMARD. The cost and effectiveness of the biological agents is an ongoing debate. keywords: abatacept; adverse; africa; agents; antibodies; antibody; arthritis; associated; available; binding; biological; cells; clinical; common; disease; dmards; dose; drugs; etanercept; factor; figure; footer; formation; fusion; il-6; immune; infections; inflammatory; inhibitors; methotrexate; molecules; monoclonal; naïve; necrosis; non; patients; psoriasis; psoriatic; reaction; receptor; response; rheumatoid; rheumatoid arthritis; risk; rituximab; soluble; south; target; therapy; tnf; tocilizumab; treatment; use; ustekinumab cache: safpj-4595.pdf plain text: safpj-4595.txt item: #226 of 251 id: safpj-4839 author: Brand, Linda title: A Quick and Painless Reminder: The Pharmacotherapy of Rheumatoid Arthritis in Primary Practice date: 2018 words: 4730 flesch: 45 summary: Rheumatoid arthritis (RA) is an auto-immune disorder with an unknown aetiology and a chronic and degenerative nature. It is associated with synovitis, vasculitis, rheumatic lung disease, pericarditis and osteoarthritis. The presence of anti-cyclic citrullinated antibodies (ACPAs) may precede the onset of RA by up to ten years. Only 75% of RA patients are seropositive for RF or ACPAs. keywords: activity; adequate; adverse; africa; ann; anti; antibodies; antirheumatic; arthritis; aspects; auto; benefit; bibliographic; biological; blood; bone; cell; chronic; clinical; conditions; current; daily; damage; day; development; disease; dmards; dose; drugs; e.g.; early; effects; efficacy; et al; eular; factors; footer; gcs; glucocorticoids; guidelines; high; immune; inflammation; inflammatory; joint; long; lymphocytes; management; med; methotrexate; months; mtx; non; number; onset; oral; page; patients; pharmacotherapy; practice; presence; primary; pro; progression; recommendations; referencingwww.tandfonline.com/oemd; response; review; rheumatoid; rheumatoid arthritis; risk; south; specific; synovial; synthetic; target; term; therapeutic; therapy; tnf; traditional; treatment; use cache: safpj-4839.pdf plain text: safpj-4839.txt item: #227 of 251 id: sajp-118 author: Mucha, C. title: Blood flow in the forearm in patients with Rheumatoid arthritis and healthy subjects under local thermotherapy date: 2002 words: 4342 flesch: 57 summary: There are differences in temperature distribution between the methods of therapy. Increasing arm baths and mud packs have a stronger influence on the thermo reflexive skin perfusion on the forearm of patients with rheumatoid arthritis and healthy subjects. keywords: 0,01; application; arm; arm bath; arthritis; bath; blood; blood flow; circulation; consensual; decimeter; decimeter wave; diathermy; differences; flow; forearm; groups; healthy; heat; incr; journal; left; measurement; method; minutes; muscle; packs; parafango; patients; post; reaction; reactive; rest; rheumatoid; short; significant; skin; subjects; temperature; test; therapeutic; therapy; thermotherapies; time; tissue; treatment; values; wave; wave bath cache: sajp-118.pdf plain text: sajp-118.txt item: #228 of 251 id: sajp-1224 author: Baldwin, Joan title: The physiotherapist and juvenile rheumatoid arthritis date: 1972 words: 3267 flesch: 74 summary: Juvenile rheum atoid arthritis is a systemic disease affecting four or more joints. The peak onset ages of the disease are between one to three years of age and seven to ten years old. It is similar to the adult form, but it differs in the type of deformity and the age of onset. keywords: activities; affected; age; arthritis; atoid; cases; children; com; contracture; daily; deformities; disease; ent; ents; exercises; extension; finger; flexion; hip; ith; joints; juvenile; knee; ore; ost; page; pain; parents; physiotherapist; pool; possible; program; results; rheum; splint; splinting; techniques; therapy; treatm; wrist; years cache: sajp-1224.pdf plain text: sajp-1224.txt item: #229 of 251 id: sajp-732 author: Ferrinho, Paulo title: A profile of patients attending the physiotherapy department at the Alexandra Health Centre and University Clinic date: 1992 words: 2647 flesch: 71 summary: There is a lack of basic data on the profile of the patients seen at the PHYSIOTHERAPY DEPARTMENT at Alexandra Health Centre and University Clinic in Alexandra, South Africa. A health information system has been partially discontinued. The A H C is developing a Community Based Rehabilitation (C B R) program. The C B R program has 4 main components: research, mobilising the community, education and training, and clinical work. keywords: acute; age; alexandra; attenders; book; burns; care; centre; chronic; clinical; com; common; data; diagnosis; ere; ferrinho; health; hospital; information; ore; p=0,00; patients; percent; physiotherapy; primary; problems; profile; program; referral; rehabilitation; repeat; services; system; university; work; years cache: sajp-732.pdf plain text: sajp-732.txt item: #230 of 251 id: sajp-844 author: Jacobson, R. title: Place of Physiotherapy in the Treatment of Rheumatoid Arthritis date: 1967 words: 6332 flesch: 96 summary: Page 6 of 1967's "A Rth Ritis society" summary is summarised in "The C a n a d ia n A rth ritis society". The society's aim is to cure sibility. keywords: c e; c o; deformity; disease; e d; e e; e n; e p; e r; e s; e u; exercise; flexion; g e; h e; hip; ice; ith; itio; join; m e; n c; n d; n n; n s; n t; o f; o n; o t; o u; pain; patient; possible; r t; rest; ritis; rth; splints; t e; t h; therapy; tic; tio; tio n; tre; u c; u n; uscle; ust; wrist cache: sajp-844.pdf plain text: sajp-844.txt item: #231 of 251 id: sajp-985 author: Mason, R. M. title: Medical/Orthopaedic Management of Rheumatoid Arthritis date: 1963 words: 3261 flesch: 101 summary: Rheumatoid Arthritis is a physical and physical disease. It is associated with c o n s titu tio n a l d is tu rb a n c e — fever, anaem ia, im p a irm e n t o f g ro w th in ch ild ren, and the presence of T h e rh e rh e fa c to r is present in the serum. keywords: d u; disease; e n; ith; n t; o f; o n; o t; o u; ritis; rth; tie; tio; tre; u t cache: sajp-985.pdf plain text: sajp-985.txt item: #232 of 251 id: sajsm-11555 author: Wilkinson, Rebecca title: Pain and physical activity levels among Rheumatoid Arthritis patients between the ages of 18 to 50 years in South Africa date: 2022 words: 6120 flesch: 53 summary: Rheumatoid arthritis is a musculoskeletal disorder with joint damage, disability and functional limitations. It can be treated with medication, but it can also be controlled with regular physical activity. It has been suggested that RA patients are less active due to joint and joint related problems. keywords: ability; active; activities; activity; affected; africa; age; arthritis; associated; average; barriers; benefits; categories; category; correlation; countries; daily; data; disease; doi; exercise; general; grooming; health; intensity; leisure; levels; management; mean; moderate; no.1; original; outcomes; pain; participants; participation; patients; personal; physical; physical activity; pmid; population; positive; present; prevalence; questionnaire; research; results; rheumatoid; sajsm; sample; south; studies; study; table; time; travel; treatment; vigorous; vol; work; years cache: sajsm-11555.pdf plain text: sajsm-11555.txt item: #233 of 251 id: sajsm-335 author: Nolte, K title: Land- and water-based exercises in rheumatoid arthritis patients: a series of case reports date: 2011 words: 4225 flesch: 61 summary: Arthritis is one of the main causes of human disability. Rheumatoid arthritis is the most common type of chronic inflammatory arthritis. The primary goal of exercise therapy for RA is to improve joint mobility, muscle strength and aerobic and functional capacity. There is a debate as to what type of exercise is the best for RA patients. keywords: activity; aerobic; age; arthritis; capacity; care; changes; clinical; control; difference; disease; effects; esr; exercise; exercise group; experimental; female; fitness; functional; grip; group; important; intervention; joint; knee; land; landand; motion; muscle; pain; parameters; patients; physical; post; pre; programme; range; research; results; rheumatoid; sjc; status; strength; study; subjects; table; test; therapy; tjc; total; treatment; walk; water cache: sajsm-335.pdf plain text: sajsm-335.txt item: #234 of 251 id: saoj-167 author: Dunn, RN title: Atlanto-axial fusion: Magerl transarticular versus Harms instrumentation techniques date: 2017 words: 3000 flesch: 55 summary: Atlanto-axial instability with post-traumatic and rheumatoid arthritis is a common condition. Transarticular screw fixation offers acceptably high fusion rates but is not possible in 18% of patients due to a high riding vertebral artery. Harms technique utilises a posterior C1 lateral mass and C2 pedicle screw. The Harms method had a slightly higher mean blood loss compared to the transarticular method. keywords: access; arch; artery; atlanto; axial; blood; c1–2; cases; dens; direction; drill; fixation; fusion; group; harms; harms technique; high; injury; instrumentation; journal; lateral; loss; mass; medial; months; non; orthopaedic; page; patients; posterior; reduction; rheumatoid; risk; saoj; screw; spine; surgery; surgical; table; technique; time; transarticular; transarticular group; union; vertebral; winter cache: saoj-167.pdf plain text: saoj-167.txt item: #235 of 251 id: saoj-200 author: Abughalya, MS title: The radiological outcome of uncemented femoral stems in rheumatoid patients undergoing total hip arthroplasty: results at minimum eight years date: 2017 words: 3197 flesch: 58 summary: Abughalya MS, Ryan P, Goga IE, and HDip MS wrote an article for South African Orthopaedic Journal. They report the radiological outcome of uncemented femoral stems in rheumatoid patients undergoing total hip arthroplasty at least 8 years after the operation. keywords: abughalya; arthritis; arthroplasty; aseptic; bone; calcar; case; cemented; cementless; clin; component; femoral; figure; fixation; follow; graph; group; hip; hip arthroplasty; hips; implant; issue.qxp_layout; joint; long; loosening; operative; orthop; orthopaedic; page; patients; primary; prostheses; radiological; reactive; replacement; resorption; results; review; revision; rheumatoid; rheumatoid arthritis; saoj; series; shielding; south; spring; stem; stress; study; subsidence; surg; surgery; term; thrs; total; total hip; years cache: saoj-200.pdf plain text: saoj-200.txt item: #236 of 251 id: saoj-377 author: Meijer, J G title: The outcome of first metatarsophalangeal joint arthrodesis using a locking plate date: 2021 words: 4055 flesch: 56 summary: Meijer JG, Gräbe JC, Greyling P. and their colleagues studied the outcomes of arthrodesis of the first metatarsophalangeal joint using a dorsal anatomical locking plate without making use of a compression cross screw fixation. They found high union rates and a low incidence of complications. keywords: additional; anatomical; ankle; arthritis; arthrodesis; bone; cases; complication; compression; cross; cross screw; data; dorsal; dorsiflexion; fixation; foot; foot ankle; fusion; hallux; indications; infection; joint; lag; locking; locking plate; low; meijer; metatarsophalangeal; mtpj; mtpj arthrodesis; neuromuscular; non; operative; orthopaedic; outcome; overall; patients; plate; post; practice; pretoria; procedure; radiological; rate; results; revision; rheumatoid; rigidus; screw; study; successful; surgery; surgical; total; union; university; use; valgus; weeks cache: saoj-377.pdf plain text: saoj-377.txt item: #237 of 251 id: saoj-577 author: Nansook, Adisha title: A retrospective comparative study of complications after total knee replacement in rheumatoid arthritis and osteoarthritis patients date: 2022 words: 4217 flesch: 54 summary: Nansook, Ryan and Paul are authors of a study of complications after total knee replacement in rheumatoid arthritis and osteoarthritis patients at Inkosi Albert Luthuli Central Hospital in South Africa. Complications included DVT, revision surgery, revision, mechanical and mechanical complications, infection, and deep vein thrombosis. keywords: african; age; arthritis; arthroplasty; cases; combined; comparative; complications; count; data; difference; disease; dvt; follow; group; higher; hiv; hospital; infection; iqr; joint; knee; late; mean; mechanical; nansook; number; orthop; osteoarthritis; overall; patients; post; primary; rates; replacement; research; revision; rheumatoid; risk; rom; significant; south; studies; study; surgery; test; time; tka; total; value; years cache: saoj-577.pdf plain text: saoj-577.txt item: #238 of 251 id: saoj-594 author: Blair, Neill R title: Truth or DAIR? A review of debridement, antibiotics and implant retention date: 2022 words: 6865 flesch: 43 summary: Debridement, antibiotics and implant retention (DAIR) is a viable treatment option in early post-operative and acute haematogenous periprosthetic joint infections (PJIs) with a stable implant. DAIR has lower success rates compared to one- and two-stage revisions, but it maintains satisfactory outcomes in selected patient groups and similar outcomes to primary arthroplasty. keywords: acute; antibiotics; antimicrobial; approach; appropriate; arthroplasty; associated; authors; blair; bone; chronic; components; criteria; crp; dair; days; debridement; diagnosis; dis; disease; duration; early; et al; exchange; factors; failure; fracture; functional; haematogenous; high; higher; hip; implant; implant retention; independent; index; infected; infections; initial; irrigation; joint; joint infections; knee; late; literature; lora; low; management; mobile; months; mrsa; negative; option; organism; orthop; outcomes; page; patients; periprosthetic; periprosthetic joint; pji; pjis; positive; postoperative; potential; present; prior; procedure; prosthesis; rates; research; resistant; retention; review; revision; risk; score; significant; sinus; soft; stage; success; success rates; successful; surgery; surgical; symptoms; table; tamayo; therapy; time; tissue; total; tract; treatment; use; van; viable; weeks; wound cache: saoj-594.pdf plain text: saoj-594.txt item: #239 of 251 id: saoj-74 author: Saragas, NP title: Adult acquired flat foot deformity: The joint-preserving procedures in stage II tibialis posterior tendon dysfunction. date: 2017 words: 5442 flesch: 57 summary: The joint-preserving procedures for AAFF deformity due to stage II tibialis posterior tendon dysfunction are an effective and preferable option to arthrodesis. Twenty-two patients were included in the prospective study. The mean AOFAS post-operative score of 89 was significantly improved. The complication rate was very low. keywords: aaff; abduction; acquired; adult; ankle; aofas; arthritis; autumn; average; bone; calcaneal; changes; classification; column; condition; cuneiform; deformity; degeneration; deltoid; disease; dysfunction; fdl; figure; fixed; flatfoot; flexible; foot; foot ankle; foot deformity; forefoot; gastrocnemius; head; hindfoot; incision; insufficiency; johnson; joint; journal; lateral; lengthening; ligament; management; mean; meary; medial; midfoot; months; navicular; operative; orthopaedic; osteotomy; page; patients; posterior; pre; preserving; procedures; ptt; radiographic; range; results; rupture; score; spring; stage; study; surg; surgical; table; talar; tendon; tibial; tibial tendon; tibialis; transfer; treatment; tuberosity; uncoverage; valgus; value; vol cache: saoj-74.pdf plain text: saoj-74.txt item: #240 of 251 id: seejph-1835 author: Kollcaku, Julia title: Correlates of rheumatoid arthritis among women in Albania date: 2016 words: 3300 flesch: 44 summary: Julia Kollcaku, Artur Kollaku and Koll caku studied the association of rheumatoid arthritis with socio-demographic and lifestyle factors among women in transitional Albania. A cross-sectional study was carried out in 2012-2013 including a sample of 2198 women aged 30 years and above who attended the Rheumatology services at primary health care clinics in Tirana municipality (mean age 60.2±9.7 years). 437 (19.9%) women were diagnosed with arthritis. keywords: age; albania; alcohol; arthritis; association; august; behavioral; care; characteristics; consumption; correlates; demographic; doi; educational; factors; health; intake; kollcaku; lifestyle; models; obesity; original; overweight; prevalence; primary; reference; research; rheumatoid; rheumatoid arthritis; rheumatology; risk; sample; seejph; seejph-2016; services; smoking; socio; status; study; tirana; unibi; women; years cache: seejph-1835.pdf plain text: seejph-1835.txt item: #241 of 251 id: sjms-9294 author: Eltahir, Mohamed Abdelrhman title: Association between Inflammatory Cytokines and Liver Functions in Rheumatoid Arthritis Patients date: 2021 words: 3000 flesch: 59 summary: Mohamed Abdelrhman Eltahir, Kawthar Abdelgaleil Mohammedsalih, Elhaj Noureldien Mohamed, Faisal Makki Babekir, and Amar Mohamed Ismail are the authors of a research article in the Sudan Journal of Medical Sciences. They studied the association between pro-inflammatory and anti-inflammatory cytokines and liver function tests in rheumatoid arthritis patients. keywords: abdelrhman; abnormal; arthritis; association; clinical; cytokines; data; disease; doi; duration; eltahir; et al; higher; il-17; inflammatory; journal; khartoum; liver; medical; mohamed; opn; page; patients; ra patients; results; rheumatoid; sciences; sjms.v16i2.9294; study; sudan; table; tests; treatment; value; vol; young cache: sjms-9294.pdf plain text: sjms-9294.txt item: #242 of 251 id: skin-29 author: Nolan, Katherine title: Minocycline-Induced Agranulocytosis Presenting as Ecthyma Gangrenosum date: 2017 words: 1638 flesch: 43 summary: A 51-year-old female with rheumatoid arthritis was admitted for progressive fever, chills, malaise, shortness of breath, and a non-productive cough. She was diagnosed with minocycline-induced agranulocytosis presenting as ecthyma gangrenosum. She developed additional abscesses on her right ankle and right axilla and spiking fevers, so she was treated with an incision and drainage under general anesthesia. Skin biopsy revealed ulceration, necrosis, acute and chronic inflammation, vasculitis with vascular thrombosis, and rod-shaped bacteria in blood vessel walls and lumina consistent with ecthymas gangren keywords: admission; agranulocytosis; antibiotics; arthritis; biopsy; blood; cell; copyright; count; cutaneous; day; department; ecthyma; fevers; following; gangrenosum; inflammation; issue; medicine; miami; minocycline; national; necrosis; neutropenia; november; patient; prior; rheumatoid; right; skin; society; treatment; university; usa; volume; weeks cache: skin-29.pdf plain text: skin-29.txt item: #243 of 251 id: skin-393 author: Dunn, Carly title: New-Onset Vitiligo Following Etanercept for Ankylosing Spondylitis date: 2019 words: 1269 flesch: 49 summary: There is an increase in reports of immune-mediated skin diseases such as lichen planus, psoriasis, or granuloma annulare following the initiation of TNF-α inhibitors. A 19-year-old male with ankylosing spondylitis was switched to etanercept and developed vitiligo shortly after. keywords: case; conditions; dermatol; disease; etanercept; factor; figure; inflammatory; inhibitors; necrosis; patient; psoriasis; reports; skin; spondylitis; study; tnf; treatment; use; vitiligo cache: skin-393.pdf plain text: skin-393.txt item: #244 of 251 id: skin-876 author: Buechler, Connor R title: Extensive Tinea Associated with Tofacitinib Therapy Masquerading as New-Onset SCLE date: 2020 words: 1657 flesch: 48 summary: A 71-year-old African American woman with rheumatoid arthritis developed a rash that spread from her stomach to her chest, back, shoulders and scalp after starting tofacitinib therapy for the arthritis. She had a history of inadequate response to or intolerance to methotrexate. keywords: arthritis; autoimmune; case; chest; copyright; course; cutaneous; dermatol; dermatophytosis; erythematous; extensive; figure; fungal; infections; inhibitor; issue; loss; medicine; national; onset; oral; patient; rash; recent; rheumatoid; scalp; september; skin; society; terbinafine; therapy; tinea; tofacitinib; treatment; trichophyton; upper; volume cache: skin-876.pdf plain text: skin-876.txt item: #245 of 251 id: squmj-4594 author: Ben Abdelghani, Kawther title: Validity of Remission Criteria in Rheumatoid Arthritis Compared to Ultrasound-Defined Remission date: 2022 words: 5363 flesch: 56 summary: Yasmine Makhlouf, Kawther Ben Abdelghani, Saoussen Miladi, Alia Fazaa, Mariem Sallemi, Leila Souebni, Kamel Ben Salem, Leith Zakraoui, Ahmed Laatar, and Selma Kassab are in remission from rheumatoid arthritis at Mongi Slim Hospital in Tunis, Tunisia. The DAS28 is the most sensitive and specific score for RA remission. keywords: abdelghani; absence; acr; active; activity; activity score; arthritis; assessment; authors; ben; calculated; cdai; clinical; composite; control; criteria; cut; das28; data; different; disease; disease activity; doppler; early; eular; eular remission; grade; group; index; joints; months; patients; power; practice; present; range; reference; remission; remission criteria; results; rheumatoid; rheumatoid arthritis; rheumatology; scale; score; sdai; selma; signals; smolen; specific; standard; strategy; stringent; studies; study; synovitis; table; treat; ultrasound; validity; value; wrists cache: squmj-4594.pdf plain text: squmj-4594.txt item: #246 of 251 id: szmc-11 author: Mariyam Iftikhar Piracha title: Radiological Analysis of Hind Paw Joint in Murine Rheumatoid Arthritis Model Treated Prophylactically Or Therapeutically with Cassia fistula versus Naproxen date: 2021 words: 2673 flesch: 52 summary: Cassia fistula has anti-inflammatory activity. It reduces the swelling of hind paw and deformity of interphalangeal joints in rats with rheumatoid arthritis. It is a potential weaker candidate to naproxen in the prevention and treatment of arthritis. keywords: 250mg; 500mg; analysis; anthraquinone; anti; arthritis; bark; cassia; cfa; college; control; deformity; department; disease; dose; effect; extract; fistula; fruit; group; hind; hind paw; indian; inflammatory; injection; interphalangeal; interphalangeal joints; joints; kg group; lahore; low; medical; methanolic; model; murine; naproxen; paw; pharmacology; prophylactic; pulp; radiological; rats; rheumatoid; rheumatoid arthritis; study; swelling; therapeutic cache: szmc-11.pdf plain text: szmc-11.txt item: #247 of 251 id: szmc-133 author: Mehdi, Quratulain title: Efficacy of Telmisartan in Pristane Induced Arthritis Rat Model date: 2021 words: 3580 flesch: 54 summary: Telmisartan is an angiotensin receptor blocker and PPAR-γ agonist and its anti-arthritic effects were evaluated. The study was conducted in the Department of Pharmacology, Army Medical College, Rawalpindi, in collaboration with National Institute of Health and Armed Forces Institute of Pathology from July 2020 to August 2020. Rheumatoid arthritis is one of the most common systemic inflammatory diseases characterized by progressive damage to the joints. keywords: absent; analysis; angiotensin; anti; army; arthritis; arthrogram; bone; cartilage; cells; college; comparison; control; count; day; department; disease; effects; efficacy; erosion; experimental; female; group; histological; induction; infiltrating; inflammation; inflammatory; injection; institute; joint; leukocyte; mean; medical; mild; model; moderate; multan; n=8; pharmacology; pristane; quetta; rats; rawalpindi; rheumatoid; sciences; score; severe; significant; slides; study; synovial; telmisartan; tlc; total; treatment; water; weeks cache: szmc-133.pdf plain text: szmc-133.txt item: #248 of 251 id: szmc-211 author: Maheen Fatima title: Colebrookea Oppositifolia Anti Arthritic Potential Vs Methotrexate in Pristane Induced Rat Arthritis date: 2022 words: 144 flesch: -2 summary: Colebrookea Oppositifolia is a plant with anti-arthritic properties and Methotrexate in Pristane Induced Rat Arthritis. She is a member of the department of Pharmacology, Post Graduate Medical Institute, Lahore, King Edward Medical University and Fatima Memorial Hospital. She also belongs to the Department of Histopathology, Jinnah Hospital and the Department Of Medicine, Sir Ganga Ram Hospital. keywords: colebrookea; oppositifolia cache: szmc-211.pdf plain text: szmc-211.txt item: #249 of 251 id: szmc-216 author: Nisar Ahmed title: Therapeutic Effect of Berberine Versus Methotrexate on Histopathology in a Rat Model of Pristane-Induced Arthritis date: 2022 words: 265 flesch: 57 summary: Berberis lycium Royle (BLR) is being treated for arthritis induction. Therapeutic Effect of Berberine Versus Methotrexate on Joint Histopathology in a Rat Model is discussed in Proceedings S.Z.M.C. Vol: 36(1): pp. 49-55, 2022. keywords: histopathology; methotrexate cache: szmc-216.pdf plain text: szmc-216.txt item: #250 of 251 id: uj-1555 author: Coskun, Burhan title: Evaluation of Sexual Function in Women with Rheumatoid Arthritis date: 2014 words: 4199 flesch: 65 summary: Burhan Coskun, Belkis Nihan Coskun and Gokhan Atis, Erbil Ergenekon, Kamil Dilek, Başak Sitesi and Doburca Cad studied the link between rheumatoid arthritis (RA) and female sexual function in 32 women with RA and 20 healthy age matched controls. Women with RA had significantly worse sexual functioning and lower quality of life. keywords: .0001; age; arousal; arthritis; bdi; body; colleagues; control; depression; desire; domain; dysfunction; female; fsd; fsfi; function; functioning; group; health; hour; lower; lubrication; max; mean; median; min; morning; orgasm; pain; patients; physical; prevalence; qol; rheumatoid; role; satisfaction; scores; sexual; sf-36; significant; social; status; stiffness; study; table; test; total; turkey; turkish; women cache: uj-1555.pdf plain text: uj-1555.txt item: #251 of 251 id: ujms-6085 author: Koakutsu, Tomoaki title: Lumbar radiculopathy caused by foraminal stenosis in rheumatoid arthritis date: 2010 words: 2699 flesch: 52 summary: Upsala Journal of Medical Sciences. 2011; 116: 133-137. Tomoaki Koakutsu, NAOKI MOROZUMI, YUTAKA KOIZUMI and YUSHIN ISHII from Nishitaga National Hospital, Sendai, Japan treated six patients with lumbar radiculopathy caused by foraminal stenosis in rheumatoid arthritis. The affected nerve roots were L4 in four of the six patients and L3 in two. Selective Radiculography with nerve root block reproduced pain and demonstrated compression of the nerve root by the superior articular process of the lower vertebrae. Conservative treatment was performed on one patient and surgery was conducted keywords: affected; arthritis; articular; cases; cervical; class; collapse; decompression; diagnosis; facet; findings; foraminal; fusion; imaging; instability; joint; lesions; lumbar; mri; nerve; neurological; pain; patients; posterior; radiculopathy; rheumatoid; right; root; section; spinal; spine; srg; stage; stenosis; treatment; vertebral; years cache: ujms-6085.pdf plain text: ujms-6085.txt