11


49

Proceedings S.Z.M.C. Vol: 36(1): pp. 49-55, 2022.       PSZMC-834-36-1-2022 

 
1Department of Pharmacology, Ayub Medical College, Abbottabad 
2Department of Pharmacology, Post Graduate Medical Institute, Lahore 
3Department of Pathology, Punjab Institute of Cardiology, Lahore 
4Department of Pharmacology, Sahara Medical College, Narowal 
5Department of Pharmacology, Shalamar Medical and Dental College, Lahore 



50

Therapeutic Effect of Berberine Versus Methotrexate on Joint Histopathology in a Rat Model… 

Berberis lycium Royle (BLR), 
Berberidiaceae

Group Group Name Arthritis induction 
Treatment Day 15 

onwards 



51

Therapeutic Effect of Berberine Versus Methotrexate on Joint Histopathology in a Rat Model… 

p 

p 

p 
p 

   

p 
p 

a-e



52

Therapeutic Effect of Berberine Versus Methotrexate on Joint Histopathology in a Rat Model… 

a-e

p 
p 

p 

p 

p 

p 

p 

100 100 0 12.5 75 
0 0 12.5 75 25 
0 0 62.5 12.5 0 
0 0 25 0 0 

p value ### ### *** *** ### ^ ### 

100 100 0 12.5 37.5 
0 0 62.5 75 62.5 
0 0 37.5 12.5 0 
0 0 0 0 0 

p value ### ### *** *** ** # 

100 100 0 25 37.5 
0 0 37.5 75 50 
0 0 50 0 12.5 
0 0 12.5 0 0 

p value ### ### *** ** ## ** # 

100 100 0 12.5 12.5 
0 0 12.5 62.5 37.5 
0 0 62.5 25 50 
0 0 25 0 0 

p value ### ### *** *** # *** # 

p p 
p p p 

p 



53

Therapeutic Effect of Berberine Versus Methotrexate on Joint Histopathology in a Rat Model… 



54

Therapeutic Effect of Berberine Versus Methotrexate on Joint Histopathology in a Rat Model… 

 

 

 

 

 

 

 

Rhizoma Coptidis

 

 

 

 

 

 

 

 

 

 

 

 

 



55

Therapeutic Effect of Berberine Versus Methotrexate on Joint Histopathology in a Rat Model…